ticker stringlengths 2 5 | disease stringlengths 3 196 | stage stringclasses 15
values | date stringlengths 19 19 | catalyst stringlengths 18 760 | label int64 -1 1 |
|---|---|---|---|---|---|
SGEN | Cancer - ALCANZA trial for relapsed CD30-positive cutaneous T-cell lymphoma | Approved | 2017-11-09 00:00:00 | Approval announced November 9, 2017. | 1 |
TGTX | Chronic Lymphocytic Leukemia (CLL) and small lymphocytic lymphoma (SLL) | Phase 3 | 2021-09-20 00:00:00 | Phase 3 results showed that 421 patients were randomized to the U2 (n=210) or O+Chl (n=211) arms; 57% of patients were treatment-naïve and 43% had relapsed/refractory (R/R) CLL. At a median follow-up of 36.7 months, U2 significantly prolonged independent review committee (IRC) assessed progression-free survival (PFS) v... | 1 |
GMAB | Non-Hodgkin Lymphoma (NHL) | Phase 1/2 | 2021-12-14 00:00:00 | Phase 1/2 data reported that 25% of patients reported Grade 4 Neutropenia, with a 73% CMR and a 27% PMR, noted December 14, 2021. | 0 |
AGIO | Sickle cell disease | Phase 2 | 2023-06-26 00:00:00 | Phase 2 portion met its primary endpoint of hemoglobin response for patients in both the 50 mg and 100 mg twice daily (BID) mitapivat arms, noted June 26, 2023 | 0 |
HRTX | Postoperative nausea and vomiting (PONV) | Approved | 2022-09-16 00:00:00 | Approved September 16, 2022. | 1 |
ZYME | Gastric/gastroesophageal junction adenocarcinoma (G/GEJC) | Phase 1/2 | 2023-10-20 00:00:00 | Phase 1b/2 data presented at ESMO reported that the confirmed objective response rate by investigator (INV) was 75.8% and median progression-free survival was 16.7 months, noted October 20, 2023. | 1 |
VIR | Mild to moderate COVID-19 | Phase 3 | 2021-03-03 00:00:00 | Independent Data and Safety Monitoring Board (DSMB) recommended that enrollment to be closed - raised concerns about the magnitude of potential benefit. | 0 |
ABBV | Biosimilar candidate to Avastin (bevacizumab) | Approved | 2017-09-14 00:00:00 | Approved September 14, 2017. | 1 |
MRK | Type 2 diabetes | Approved | 2017-12-20 00:00:00 | Approval announced December 20, 2017. | 1 |
AVXL | Parkinson’s Disease Dementia (PDD) | Phase 2 | 2023-03-30 00:00:00 | Phase 2 study data met primary and key secondary endpoints, noted March 30, 2023. | 0 |
IMVIQ | Metastatic Bladder and Micro-Satellite Instability High (MSI-H) Solid Tumors | Phase 2 | 2019-09-30 00:00:00 | Phase 2 data at ESMO 2019 noted 2/23 PRs. | 0 |
CTMX | Solid tumors / Diffuse large B-cell lymphoma (DLBCL), squamous non-small cell lung cancer (sqNSCLC), head and neck squamous cell carcinoma, and esophageal/gastro-esophageal junction (E/GEJ) cancer | Phase 2 | 2021-12-20 00:00:00 | Phase 2 initial data reported an objective response rate of 18.8% and disease control rate of 87.5% in squamous non-small cell lung cancer. In advanced head and neck squamous cell carcinoma with objective response rate of 4.0 percent and disease control rate of 56.0 percent, noted December 20, 2021. | 0 |
LEGN | Multiple Myeloma | Phase 3 | 2023-06-05 00:00:00 | Phase 3 results shared at ASCO demonstrated a statistically significant improvement in progression-free survival, with a hazard ratio of 0.26, noted June 5, 2023 | 1 |
VRDN | Active Thyroid Eye Disease (TED) | Phase 1/2 | 2023-07-10 00:00:00 | Phase 1/2 preliminary data demonstrated clinically meaningful and rapid improvement in signs and symptoms of chronic TED at week 6 after receiving two infusions of VRDN-001 10 mg/kg or 3 mg/kg, noted July 10, 2023. | 1 |
TNXP | Fibromyalgia | Phase 3 | 2023-06-15 00:00:00 | Phase 3 met the primary endpoint on its RELIEF trial, noted June 15, 2023 | 0 |
REGN | Non-small cell lung cancer (NSCLC) | Phase 2 | 2023-10-31 00:00:00 | Phase 2 preliminary efficacy data reported a 100% Disease Control Rate (DCR), noted October 31, 2023. | 0 |
GNPX | Non-small cell lung cancer (NSCLC) | Phase 1 | 2023-06-03 00:00:00 | Phase 1 data shared at ASCO reported that treatment was well tolerated, and there were no dose limiting toxicities, noted June 3, 2023. | 1 |
MRK | Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (HABP/VABP) | Approved | 2020-06-04 00:00:00 | FDA approval announced June 4, 2020. | 1 |
SNY | Eosinophilic esophagitis (EoE) in 1-11 year olds | Phase 3 | 2022-07-14 00:00:00 | Phase 3 data reported that trial met its primary endpoint, noted July 14, 2022. | 0 |
PCSA | Gastroparesis | Phase 2a | 2023-05-06 00:00:00 | Phase 2a data reported at DDW noted that treatment improved both gastroparesis symptom scores and gastric emptying rate, noted May 6, 2023. | 1 |
NWBO | Glioblastoma multiforme (GBM) | Phase 3 | 2022-11-17 00:00:00 | Phase 3 data reported that both median survival and "Long Tail" of extended survival were increased in both newly diagnosed and recurrent glioblastoma, noted November 17, 2022. | 0 |
PTCT | Huntington's disease | Phase 2 | 2023-06-28 00:00:00 | Phase 2 trial initiated March 30, 2022. Phase 2 trial data reported that treatment was well tolerated, with no treatment related serious adverse events and no adverse events leading to discontinuation, noted June 28, 2023. | 1 |
DBVT | Peanut allergy - ages 1 to 3 years | Phase 3 | 2023-02-24 00:00:00 | Phase 3 data due presented at AAAAI reported that data demonstrate that treatment with Viaskin Peanut 250 μg for up to 36 months in peanut-allergic children was generally safe and well tolerated, noted February 24, 2023. | 1 |
IMUX | COVID-19 | Phase 2 | 2021-02-17 00:00:00 | Phase 2 top-line data released February 17, 2021 - low rates of COVID-19 prevented the primary endpoint from being evaluable. | 1 |
MRK | Resectable Stage II, IIIA or IIIB Non-Small Cell Lung Cancer (NSCLC) | Approved | 2023-10-16 00:00:00 | Approved on October 16, 2023. | 1 |
FBIO | Postoperative pain following bunionectomy surgery | CRL | 2022-02-15 00:00:00 | FDA AdCom Meeting resulted in a 8-14 vote against the question that the application showed that benefits outweighs the risks, noted February 15, 2022. | 1 |
AEZS | Endometrial cancer | Phase 3 | 2017-05-01 00:00:00 | Phase 3 trial did not meet primary endpoint - May 1, 2017. | 1 |
AMGN | Biosimilar candidate to Avastin (bevacizumab) | Approved | 2017-09-14 00:00:00 | Approved September 14, 2017. | 1 |
ALGS | Nonalcoholic steatohepatitis (NASH) | Phase 1 | 2023-03-29 00:00:00 | Phase 1 data presented at the Hepatology Conference demonstrated a favorable safety and pharmacokinetic profile in healthy volunteers and subjects with hyperlipidemia, March 29, 2023. | 1 |
ENTA | COVID-19 | Phase 2 | 2023-05-08 00:00:00 | Phase 2 trial met primary endpoint, noted May 8, 2023. | 0 |
TXMD | Contraception | Approved | 2018-08-10 00:00:00 | FDA Approval announced August 10, 2018. | 1 |
QURE | Huntington's disease | Phase 1/2 | 2023-06-21 00:00:00 | Phase 1/2 early clinical data demonstrate trends consistent with a potential clinical benefit of AMT-130 at both doses, noted June 21, 2023. | 1 |
FRLN | Gaucher disease | Phase 1/2 | 2023-10-25 00:00:00 | Phase 1/2 results shared at the ESGCT reported no infusion reactions and no serious adverse events, noted October 25, 2023. | 0 |
BPTH | Solid tumors | Phase 1 | 2023-07-17 00:00:00 | Phase 1/1b first cohort completed, noted July 17, 2023 | 0 |
RHHBY | Castration-resistant prostate cancer | Phase 3 | 2020-06-19 00:00:00 | Phase 3 data met one of two co-primary endpoints - June 19, 2020. | 0 |
BGNE | Squamous non-small cell lung cancer (NSCLC) | Phase 3 | 2020-01-21 00:00:00 | Phase 3 trial met primary endpoint of PFS at interim analyses. | 0 |
KNSA | Chronic Pruritus | Phase 2 | 2020-05-11 00:00:00 | Phase 2 interim data released May 11, 2020. | 0 |
MRK | Facioscapulohumeral muscular dystrophy | Phase 2 | 2019-09-16 00:00:00 | Phase 2 data did not achieve statistically significant improvements in functional endpoints relative to placebo - September 16, 2019. | 1 |
MLYS | Hypertension | Phase 2 | 2023-11-02 00:00:00 | Phase 2 data to be presented ASN further supports obesity-associated dysregulated aldosterone as an endotype predictive of enhanced response, noted November 2, 2023. | 1 |
FDMT | X-linked retinitis pigmentosa (XLRP) | Phase 1/2 | 2021-10-10 00:00:00 | Phase 1/2 initial results showed that dosing was well tolerated in all patients treated to-date, with no dose-limiting toxicities, no serious adverse events and no chronic inflammation, noted October 10, 2021 | 1 |
KPTI | Quadruple Refractory Multiple Myeloma | Approved | 2019-07-03 00:00:00 | FDA Approval announced July 3, 2019. Continued approval may be contingent upon data from its Phase 3 Boston trial (data due late-2019/early 2020). | 1 |
DNLI | Healthy Volunteers | Phase 1 | 2021-10-06 00:00:00 | Phase 1 data noted that treatment was well tolerated for up to 14 days of dosing, with robust distribution in the central nervous system (CNS) and predictable dose-related increases in exposure with a PK profile supporting once daily dosing, noted October 6, 2021. | 1 |
BGNE | Refractory chronic lymphocytic leukemia (CLL) | Phase 3 | 2023-06-15 00:00:00 | Phase 3 results presnted at ICML In a subgroup analysis showed improved PFS over ibrutinib in patients in China, consistent with the global study population, noted June 15, 2023. | 1 |
PALI | Reduction in adhesions following abdominal and pelvic surgery | Phase 2 | 2023-08-09 00:00:00 | Phase 2 study did not achieve primary efficacy endpoint of reducing adhesions in LB1148 treated patients compared to placebo treated patients post bowel resection surgery, noted August 9, 2023. | 1 |
NCNA | Pancreatic cancer | Phase 3 | 2019-08-20 00:00:00 | Phase 3 enrolment suspended due to futility - August 20, 2019. | 0 |
INCY | Polycythemia Vera | Approved | 2014-12-04 00:00:00 | Approved December 4, 2014. | 1 |
NBIX | Essential Tremor | Phase 2 | 2022-08-04 00:00:00 | Phase 2 trial did not meet primary endpoints, noted August 4, 2022. | 1 |
PFE | Ulcerative colitis | Phase 3 | 2022-03-29 00:00:00 | Phase 3 data met the co-primary endpoints of clinical remission at both weeks 12 and 52 and all key secondary endpoints, noted March 29, 2022. | 0 |
MRK | Triple negative breast cancer (TNBC) | Approved | 2021-07-27 00:00:00 | FDA approval announced July 27, 2021. | 1 |
GILD | Pre-exposure prophylaxis | Approved | 2019-10-03 00:00:00 | FDA Approval announced October 3, 2019. | 1 |
DCPH | Gastrointestinal Stromal Tumors (GIST) - fourth-line | Approved | 2020-05-15 00:00:00 | FDA Approval announced May 15, 2020. | 1 |
NVIV | Complete Thoracic AIS A Spinal Cord Injury | Phase 3 | 2023-03-09 00:00:00 | Pivotal trial did not meet the primary endpoint, noted March 9, 2023. | 1 |
VERA | Kidney transplant | Phase 2 | 2022-06-04 00:00:00 | Phase 2 data results showed that the antiviral effect was higher in the dosed group than the placebo group. Further, the treatment was well tolerated, with a comparable frequency of adverse events and serious adverse events between groups | 1 |
MRK | First-Line Nonsquamous Non-small cell lung cancer (NSCLC) | Approved | 2018-06-05 00:00:00 | FDA approval (label expansion) announced June 5, 2018. | 1 |
EGRX | Malignant hyperthermia - cancer | Approved | 2014-07-23 00:00:00 | Approved July 23, 2014 under priority review. | 1 |
PFE | Gastric cancer | Phase 3 | 2019-11-08 00:00:00 | Phase 3 endpoint not met - November 8, 2019. | 0 |
INDP | Advanced/metastatic solid tumors | Phase 1 | 2023-10-31 00:00:00 | Phase 1 data abstract to be presented at SITC on November 4, 2023 noted that each of the first cohort participants experienced transient activation of biomarkers associated with innate and/or adaptive immune responses, and generally expected transient adverse events, noted October 31, 2024. | 1 |
ACXP | C. difficile Infection | Phase 2b | 2023-11-02 00:00:00 | Phase 2a and 2b data reported an observed Clinical Cure rate in the combined Phase 2 trials in patients with CDI was 96%, noted November 2, 2023. | 1 |
SAGE | Postpartum Depression - moderate | Approved | 2019-03-19 00:00:00 | FDA approval announced March 19, 2018. | 1 |
TCRX | Hematologic malignancies | Phase 1 | 2023-11-02 00:00:00 | Phase 1 data from abstract reported that the safety analysis found expected post-HCT adverse events similar in treatment and control arms. Incidence of graft-versus-host disease (GvHD) was similar in control (3 events) and treatment arms, noted November 2, 2023. | 1 |
NVS | Wet macular degeneration | Phase 3 | 2023-08-15 00:00:00 | Phase 3 trial met its primary endpoint, noted August 15, 2023. | 0 |
ABBV | Follicular lymphoma (FL) | Phase 1/2 | 2023-06-28 00:00:00 | Phase 1/2 FL cohort data reported an overall response rate (ORR) of 82% and that the median duration of response (DOR) was not reached, noted June 28, 2023. | 1 |
ADMP | Emergency treatment of anaphylaxis | Approved | 2017-06-15 00:00:00 | CRL issued March 27 2015. CRL issued again June 6, 2016. Approval announced June 15, 2017 following third submission. | 1 |
TALS | COVID-19 in living donor kidney transplant (LDKT) patients | Phase 2 | 2022-06-07 00:00:00 | Additional Phase 2 data presented at ATC reported that none of these 18 patients lost chimerism as a result of their COVID-19 vaccination, noted June 7, 2022. | 1 |
FWBI | COVID-19-related gastrointestinal (GI) infections | Phase 2 | 2022-04-29 00:00:00 | Phase 2 top-line data reported that trial did not meet its primary endpoint, noted April 29, 2022. | 1 |
ALXO | Acute myeloid leukemia (AML) | Phase 1 | 2022-12-12 00:00:00 | Additional Phase 1 data reported that treatment is well-tolerated with 4 patients achieving a response, noted December 12, 2022. | 1 |
ATHX | Acute Respiratory Distress Syndrome | Phase 1/2 | 2022-02-02 00:00:00 | Phase 1/2 data reported a median 18.5 ventilator-free days compared to 6.5 days for placebo. 25% of the treatment group reported mortality compared to 40% in placebo, noted February 2, 2022. | 1 |
VNDA | Jet Lag Disorder | CRL | 2019-08-19 00:00:00 | CRL issued August 19, 2019. | 0 |
TFFP | Invasive Pulmonary Aspergillosis (IPA) | Phase 2 | 2022-11-01 00:00:00 | Phase 2 trial data showed that second patient treated to clinically benefit from administration in compassionate use program, noted November 1, 2022. | 1 |
INVA | Chronic obstructive pulmonary disease (COPD) | Approved | 2017-09-18 00:00:00 | Approval announced September 18, 2017. | 1 |
ICPT | NASH patients with compensated cirrhosis | Phase 3 | 2023-08-02 00:00:00 | NASH Programs discontinued, noted August 2, 2023. | -1 |
NVTA | Early-seizure-onset SCN2A developmental and epileptic encephalopathy (DEE) | Phase 3 | 2023-10-02 00:00:00 | Phase 3 results from preliminary analysis of PRAX-222 Part 1 showed 44% median reduction in seizures after three doses for SCN2A-gain-of-function pediatric patients, noted October 2, 2023. | 1 |
ARVN | ER+ positive / HER2- negative breast cancer | Phase 1b | 2021-12-13 00:00:00 | Phase 1 dose escalation data reported that treatment was well tolerated with no DLTs at total daily doses up to 700mg, noted December 13, 2021. | 1 |
ABBV | B-cell Lymphoma (DLBCL) | Approved | 2023-05-22 00:00:00 | Approved May 19, 2023. | 1 |
GILD | Hepatitis B virus (HBV) infection in pediatric patients 12 years of age and older | Approved | 2022-11-02 00:00:00 | Approved November 2, 2022. | 1 |
AZN | Metastatic non-small cell lung cancer (NSCLC) | Phase 1b | 2023-06-05 00:00:00 | Phase 1b presented at ASCO demonstrated objective response rates of 57% and 50%, respectively, with a disease control rate of 91% across cohorts, noted June 6, 2023 | 1 |
BMY | Solid tumors | Phase 1 | 2021-10-07 00:00:00 | Phase 1 updated data noted a confirmed responses for a cORR of 36% out of the 11 MET TKI-naïve NSCLC patients, cORR of 33% for the nine MET TKI-naïve GC/GEJ patients, and among the 12 patients with advanced other solid tumors, one patient with MET amplified colorectal cancer achieved a confirmed response, noted October... | 1 |
ITOS | Solid tumors | Phase 1/2 | 2021-06-04 00:00:00 | Phase 1/2 single agent data at ASCO June 4, 2021 noted 5/21 patients with stable disease in including two partial responses. | 0 |
PTGX | Crohn's disease | Phase 2 | 2021-11-03 00:00:00 | Phase 2 trial and candidate development has been stopped, noted November 3, 2021. | -1 |
VSTM | Low-grade serous ovarian cancer (LGSOC) | Phase 2 | 2023-05-25 00:00:00 | Additional Phase 2 data from abstract reported a confirmed objective response rates (ORR) by blinded independent central review of 45%, noted May 25, 2023. | 0 |
TAK | Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) | NDA Filing | 2023-06-20 00:00:00 | Phase 3 full result findings showed a clinically significant reduction in relapse rate as well as a delayed time to relapse compared to placebo when used as a maintenance therapy, noted June 20, 2023. NDA under current review by the FDA. | 1 |
SNPX | Alzheimer's disease | Phase 2b | 2023-09-09 00:00:00 | Phase 2b data presented at IBRO reported that nearly all pre-specified secondary endpoints were achieved with statistical significance in the server cohort, noted September 9, 2023. | 1 |
AZN | Monotherapy for expanded use in women with HR+, HER2- advanced breast cancer | Approved | 2017-08-28 00:00:00 | Expanded approval announced August 28, 2017. | 1 |
BXRX | Acute pain following bunionectomy surgery | Approved | 2020-02-20 00:00:00 | FDA Approval announced February 20, 2020. | 1 |
ATAI | Treatment Resistant Depression (TRD) | Phase 2b | 2021-11-15 00:00:00 | Phase 2b trial met primary endpoint noted November 2021. | 0 |
REGN | Stage II to IV resectable cutaneous squamous cell carcinoma (CSCC) | Phase 2 | 2023-10-23 00:00:00 | Phase 2 data from ESMO 23 reported a 89% event-free survival rate at one year, and no disease recurrence among patients who achieved a pCR (n=40), noted October 23, 2023. | 1 |
ABBV | Multiple Myeloma | Phase 1/2 | 2021-12-13 00:00:00 | Phase 1/2 safety and preliminary efficacy data reported that treatment of patients with t(11;14) RRMM using VenDd and those with RRMM with VenDvd demonstrated a tolerable safety profile and an overall response rate (ORR) of 95.8% and 91.7%, respectively, noted December 13, 2021. | 1 |
ALNY | Hypercholesterolemia | Approved | 2021-12-22 00:00:00 | Approved December 22, 2021. | 1 |
GSK | Ovarian cancer | Approved | 2019-10-23 00:00:00 | FDA Approval announced October 23, 2019. | 1 |
HRMY | Excessive daytime sleepiness associated with Prader-Willi Syndrome (PWS) | Phase 2 | 2023-07-20 00:00:00 | EoP2 meeting completed, noted July 20, 2023 | 1 |
MEIP | Relapsed/refractory Follicular Lymphoma (FL) Non Hodgkin Lymphoma | Phase 2 | 2022-06-04 00:00:00 | Phase 2 top-line data presented at ASCO 22 reported a 70.3% objective response rate and that 35.2% achieved a complete response. 87.5% of responses achieved in first two cycles of therapy, 75% of CRs in first four cycles, 9.9% of patients discontinued the trial due to drug related adverse events, follow-up time for res... | 1 |
KROS | Pulmonary arterial hypertension (PAH) and disorders associated with bone loss | Phase 2 | 2023-05-22 00:00:00 | Phase 2 biomarker reported that treatment led to changes in serum proteins involved in structural remodeling pathways and inflammation consistent with that seen in preclinical studies, noted May 22, 2023. | 1 |
STOK | Dravet Syndrome | Phase 1/2 | 2023-07-25 00:00:00 | Phase 1/2a new data suggest clinical benefit for patients 2 to 18 years of age treated with multiple doses of STK-001. The observed reductions in convulsive seizure frequency as well as substantial improvements in cognition and behavior support the potential for disease modification in a highly refractory patient popul... | 1 |
GRTS | Colorectal Cancer / Gastric Cancer | Phase 1/2 | 2021-09-17 00:00:00 | Phase 1/2 data showed a 44% molecular response rate (4/9) and extended median overall survival >17 months, September 17, 2021. | 1 |
CAPR | COVID-19 | Phase 2 | 2022-03-28 00:00:00 | Phase 2 met safety primary endpoint, with an overall mortality of 20% and 5 deaths in the treatment group, noted March 28, 2022. | 1 |
LUMO | Pediatric Growth Hormone Deficiency (PGHD) | Phase 2 | 2023-06-21 00:00:00 | Phase 2 interim data shared at KOL demonstrate a durable response to LUM-201 from 6 to 12 months, noted June 21, 2023. | 1 |
IMVT | Autoimmune diseases | Phase 1 | 2023-09-26 00:00:00 | Phase 1 data reported no dose-related changes in serum albumin or LDL-C, and the mean total IgG reduction from baseline in this MAD cohort was 63%, noted September 26, 2023. | 1 |
ZYNE | Fragile X syndrome | Phase 2/3 | 2022-05-13 00:00:00 | Phase 2/3 long-term data reported that sustained improvement in ABC-CFXS Social Avoidance from baseline, noted May 13, 2022. | 1 |
ETON | Methanol poisoning | CRL | 2023-06-28 00:00:00 | CRL Announced on June 28, 2023. | 0 |
BMY | COVID-19 | Phase 3 | 2022-06-02 00:00:00 | Phase 3 data reported that the risk of death was lower for participants who received Orencia at 11%, versus 15% for those who received placebo, and the odds of dying were 37.4% lower, noted June 2, 2022. | 0 |
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