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en | Since HUVECs released superoxide anions in response to TNF , and H2O2 induces VCAM-1 , PDTC may act as a radical scavenger . | [
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en | Although ICAM-1 induction was unaffected , inhibitors of NADPH oxidase ( apocynin ) or cytochrome P-450 ( SKF525a ) suppressed VCAM-1 induction by TNF , revealing that several radical-generating systems are involved in its regulation . | [
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en | PDTC , apocynin , or SKF525a decreased adhesion of monocytic U937 cells to TNF-treated HUVECs ( by 75 % at 100 mumol/L PDTC ) . | [
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en | Inhibition by anti-VCAM-1 monoclonal antibody 1G11 indicated that U937 adhesion was VCAM-1 dependent and suppression by antioxidants was due to reduced VCAM-1 induction . | [
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en | ( ABSTRACT TRUNCATED AT 250 WORDS ) | [] |
en | Displacement of an E-box-binding repressor by basic helix-loop-helix proteins : implications for B-cell specificity of the immunoglobulin heavy-chain enhancer . | [
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en | The activity of the immunoglobulin heavy-chain ( IgH ) enhancer is restricted to B cells , although it binds both B-cell-restricted and ubiquitous transcription factors . | [
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en | Activation of the enhancer in non-B cells upon overexpression of the basic helix-loop-helix ( bHLH ) protein E2A appears to be mediated not only by the binding of E2A to its cognate E box but also by the resulting displacement of a repressor from that same site . | [
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en | We have identified a `` two-handed '' zinc finger protein , denoted ZEB , the DNA-binding specificity of which mimics that of the cellular repressor . | [
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en | By employing a derivative E box that binds ZEB but not E2A , we have shown that the repressor is active in B cells and the IgH enhancer is silenced in the absence of binding competition by bHLH proteins . | [
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en | Hence , we propose that a necessary prerequisite of enhancer activity is the B-cell-specific displacement of a ZEB-like repressor by bHLH proteins . | [
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en | Inhibition of NF-kappa B by sodium salicylate and aspirin [ see comments ] | [
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en | The transcription factor nuclear factor-kappa B ( NF-kappa B ) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 ( IL-1 ) , IL-6 , and adhesion molecules . | [
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en | The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B , which further explains the mechanism of action of these drugs . | [
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en | This inhibition prevented the degradation of the NF-kappa B inhibitor , I kappa B , and therefore NF-kappa B was retained in the cytosol . | [
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en | Sodium salicylate and aspirin also inhibited NF-kappa B -dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus ( HIV ) long terminal repeat ( LTR ) in transfected T cells . | [
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en | Effects of the antisense myb expression on hemin- and erythropoietin- induced erythroid differentiation of K562 cells . | [
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en | In order to elucidate the role of c-myb gene in erythroid differentiation of K562 cell induced by hemin ( Hm ) and erythropoietin ( Epo ) , we constructed recombinant plasmid that could produce antisense myb RNA after induction with dexamethasone . | [
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en | During treatment with Hm , K562 cells constitutively expressed c-myb mRNA , and 50 % of them began to synthesize hemoglobin ( Hb ) . | [
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en | Expression of antisense myb RNA reduced the amount of c-myb mRNA , and the percentage of Hb-synthesizing cells was decreased to 20 % . | [
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en | In the presence of Epo , c-myb mRNA declined and 20 % of K562 cells synthesized Hb regardless of antisense myb RNA expression . | [
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en | It is suggested that constitutive expression of c-myb mRNA is necessary for Hm -induced differentiation , and that a decrease in the amount of c-myb mRNA induced by antisense myb RNA expression suppresses Hm -induced differentiation . | [
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en | The amount of c-myb mRNA in K562 cells was reduced during the differentiation induced by Epo . | [
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en | Expression of GATA-1 mRNA was almost constant during Hm -induced differentiation , but increased during Epo treatment . | [
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en | It is supposed that the mechanism of Hm -induced differentiation is distinguished from that of Epo -induced differentiation in K562 cells . | [
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en | Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats . | [] |
en | We investigated whether non-abortive maternal infections would compromise fetal brain development and alter hypothalamic-pituitary-adrenocortical ( HPA ) axis functioning when adult . | [] |
en | To study putative teratogenic effects of a T cell-mediated immune response versus an endotoxic challenge , 10-d-pregnant rats received a single intraperitoneal injection of 5 x 10 ( 8 ) human red blood cells ( HRBC ) or gram-negative bacterial endotoxin ( Escherichia coli LPS : 30 micrograms/kg ) . | [
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en | The adult male progeny ( 3 mo old ) of both experimental groups showed increased basal plasma corticosterone levels . | [] |
en | In addition , after novelty stress the HRBC group , but not the LPS group , showed increased ACTH and corticosterone levels . | [
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en | Both groups showed substantial decreases in mineralocorticoid ( MR ) and glucocorticoid receptor ( GR ) levels in the hippocampus , a limbic brain structure critical for HPA axis regulation , whereas GR concentrations in the hypothalamus were unchanged and in anterior pituitary were slightly increased . | [
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en | HRBC and LPS indeed stimulated the maternal immune system as revealed by specific anti-HRBC antibody production and enhanced IL-1 beta mRNA expression in splenocytes , respectively . | [
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en | This study demonstrates that a T cell-mediated immune response as well as an endotoxic challenge during pregnancy can induce anomalies in HPA axis function in adulthood . | [] |
en | Clinically , it may be postulated that disturbed fetal brain development due to prenatal immune challenge increases the vulnerability to develop mental illness involving inadequate responses to stress . | [] |
en | A low NM23.H1 gene expression identifying high malignancy human melanomas . | [
{
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en | The NM23 gene has been proposed as a metastasis-suppressor gene , and its use has been suggested as prognostic factor . | [
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en | NM23 was identified in a system of murine melanoma cell lines , in which an inverse relationship was found between NM23 expression and metastatic ability . | [
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en | In a human malignant melanoma study NM23 expression was found to be significantly lower in metastases that developed less than 24 months after diagnosis of the primary tumours . | [
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en | The present paper studies the expression of the NM23.H1 gene in cell lines which derive from primary or metastatic human malignant melanomas in relation to staging , infiltration degree , lymphocytic infiltration , cell morphology , cell pigmentation , karyotype , and disease-free survival . | [
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en | The level of mRNA expression of the NM23 gene is significantly lower in cell lines that derive from more infiltrating primary melanomas than in cell lines obtained from less infiltrating tumours . | [
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en | Moreover , cell lines derived from tumours of patients with a disease-free survival of more than 24 months ( 24-58 months ) express the NM23 gene at higher levels than cell lines obtained from melanomas of patients with a disease-free survival of less than 24 months ( 6-15 months ) . | [
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en | Activation of a novel serine/threonine kinase that phosphorylates c-Fos upon stimulation of T and B lymphocytes via antigen and cytokine receptors . | [
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en | Ligation of Ag receptors in T and B lymphocytes initiates signal transduction cascades which alter the expression of genes that regulate cellular proliferation and differentiation . | [
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en | The transmission of signals from the membrane to the nucleus is mediated principally through the action of protein tyrosine and serine/threonine kinases . | [
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en | We have identified and characterized a novel serine/threonine kinase that phosphorylated the proto-oncogene product , c-Fos , and is termed Fos kinase . | [
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en | Fos kinase was rapidly activated after ligation of the CD3 and CD2 receptors in Jurkat and normal human T lymphocytes and in response to IL-6 and anti-IgM in the human B cell lines AF10 and Ramos , respectively . | [
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en | The phorbol ester , PMA , was also a potent inducer of Fos kinase activity in all of the above populations , suggesting that PKC plays a role in the regulation of this enzyme . | [
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en | Fos kinase phosphorylates c-Fos at a site near the C-terminus , as well as a peptide derived from this region ( residues 359-370 , RKGSSSNEPSSD ) , and Fos peptide competitively inhibited c-Fos phosphorylation . | [
{
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en | Fos kinase was shown to be distinct from other identified serine/threonine kinases , including protein kinase A , protein kinase C , casein kinase II , MAP kinases , p70S6K and p90RSK . | [
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en | Fos kinase was purified by anion exchange chromatography and exhibited an apparent M ( r ) = 65 , 000 and isoelectric point = 6.1 . | [
{
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en | Fos kinase may play a role in transcriptional regulation through its capacity to phosphorylate c-Fos at a site required for expression of the transcriptional transrepressive activity of this molecule . | [
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en | Moreover , its rapid activation suggests it may have a wider role within signal transduction cascades in lymphocytes . | [
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"label": "cell_type",
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] |
en | Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions . | [
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"value": "human CD4+ T-cell clones"
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en | Lesions resulting from recurrent genital herpes simplex virus ( HSV ) infection are characterized by infiltration of CD4+ lymphocytes . | [
{
"start": 117,
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"label": "cell_type",
"value": "CD4+ lymphocytes"
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en | We have investigated the antigenic specificity of 47 HSV-specific CD4+ T-cell clones recovered from the HSV-2 buttock and thigh lesions of five patients . | [
{
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"value": "HSV-specific CD4+ T-cell clones"
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] |
en | Clones with proliferative responses to recombinant truncated glycoprotein B ( gB ) or gD of HSV-2 or purified natural gC of HSV-2 comprised a minority of the total number of HSV-specific clones isolated from lesions . | [
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{
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{
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en | The gC2- and gD2-specific CD4+ clones had cytotoxic activity . | [
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en | The approximate locations of the HSV-2 genes encoding HSV-2 type-specific CD4+ antigens have been determined by using HSV-1 x HSV-2 intertypic recombinant virus and include the approximate map regions 0.30 to 0.46 , 0.59 to 0.67 , 0.67 to 0.73 , and 0.82 to 1.0 units . | [
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] |
en | The antigenic specificity of an HLA DQ2-restricted , HSV-2 type-specific T-cell clone was mapped to amino acids 425 to 444 of VP16 of HSV-2 by sequential use of an intertypic recombinant virus containing VP16 of HSV-2 in an HSV-1 background , recombinant VP16 fusion proteins , and synthetic peptides . | [
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en | Each of the remaining four patients also yielded at least one type-specific T-cell clone reactive with an HSV-2 epitope mapping to approximately 0.67 to 0.73 map units . | [
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en | The antigenic specificities of lesion-derived CD4+ T-cell clones are quite diverse and include at least 10 epitopes . | [
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en | Human T-cell clones reactive with gC and VP16 are reported here for the first time . | [
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"end": 45,
"label": "protein",
"value": "VP16"
}
] |
en | Marked basophilia in acute promyelocytic leukaemia treated with all-trans retinoic acid : molecular analysis of the cell origin of the basophils . | [
{
"start": 135,
"end": 144,
"label": "cell_type",
"value": "basophils"
}
] |
en | We report a patient with acute promyelocytic leukaemia who developed marked basophilia during all-trans retinoic acid treatment . | [] |
en | We studied genomic DNA and RNA extracted from the patient 's peripheral leucocytes in order to determine the origin of the basophils . | [
{
"start": 11,
"end": 22,
"label": "DNA",
"value": "genomic DNA"
},
{
"start": 61,
"end": 82,
"label": "cell_type",
"value": "peripheral leucocytes"
},
{
"start": 123,
"end": 132,
"label": "cell_type",
"value": "basophils"
}
] |
en | The RAR alpha rearranged band in the Southern blot analysis and a chimaeric product of PML-RAR alpha by polymerase chain reaction were strongly visible before ATRA treatment , but at the time of maximal basophilia both of them were markedly diminished . | [
{
"start": 4,
"end": 13,
"label": "protein",
"value": "RAR alpha"
},
{
"start": 66,
"end": 83,
"label": "protein",
"value": "chimaeric product"
},
{
"start": 87,
"end": 100,
"label": "protein",
"value": "PML-RAR alpha"
}
] |
en | These findings suggest that the basophils which appeared during the ATRA treatment are reactive in nature rather than a leukaemic clone . | [
{
"start": 32,
"end": 41,
"label": "cell_type",
"value": "basophils"
},
{
"start": 120,
"end": 135,
"label": "cell_line",
"value": "leukaemic clone"
}
] |
en | Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B [ published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11 ; 92 ( 8 ) : 3632 ] | [
{
"start": 18,
"end": 36,
"label": "DNA",
"value": "interleukin 6 gene"
},
{
"start": 104,
"end": 126,
"label": "protein",
"value": "nuclear factors NF-IL6"
},
{
"start": 131,
"end": 141,
"label": "protein",
"value": "NF-kappa B"
}
] |
en | The host response to Mycobacterium tuberculosis includes granuloma formation at sites of infection and systemic symptoms . | [] |
en | Cytokines have been identified by immunohistochemistry in granulomas in animal models of bacillus Calmette-Guerin ( BCG ) infection and are released by mononuclear phagocytes upon stimulation by mycobacterial proteins . | [
{
"start": 0,
"end": 9,
"label": "protein",
"value": "Cytokines"
},
{
"start": 152,
"end": 174,
"label": "cell_type",
"value": "mononuclear phagocytes"
}
] |
en | In this regard , the cytokine interleukin 6 ( IL-6 ) may play a role in the clinical manifestations and pathological events of tuberculosis infection . | [
{
"start": 21,
"end": 29,
"label": "protein",
"value": "cytokine"
},
{
"start": 30,
"end": 43,
"label": "protein",
"value": "interleukin 6"
},
{
"start": 46,
"end": 50,
"label": "protein",
"value": "IL-6"
}
] |
en | We have demonstrated that lipoarabinomannan ( LAM ) from the mycobacterial cell wall , which was virtually devoid of lipopolysaccharide ( LPS ) , stimulated mononuclear phagocytes to release IL-6 in a dose-response manner . | [
{
"start": 26,
"end": 43,
"label": "protein",
"value": "lipoarabinomannan"
},
{
"start": 46,
"end": 49,
"label": "protein",
"value": "LAM"
},
{
"start": 157,
"end": 179,
"label": "cell_type",
"value": "mononuclear phagocytes"
},
{
"start": 191,
"en... |
en | LAM and LPS were potent inducers of IL-6 gene expression in peripheral blood monocytes . | [
{
"start": 0,
"end": 3,
"label": "protein",
"value": "LAM"
},
{
"start": 36,
"end": 45,
"label": "DNA",
"value": "IL-6 gene"
},
{
"start": 60,
"end": 86,
"label": "cell_type",
"value": "peripheral blood monocytes"
}
] |
en | Both LAM -and LPS-inducible IL-6 promoter activity was localized to a DNA fragment , positions -158 to -49 , by deletion analysis and chloramphenicol acetyltransferase assay . | [
{
"start": 5,
"end": 8,
"label": "protein",
"value": "LAM"
},
{
"start": 14,
"end": 41,
"label": "DNA",
"value": "LPS-inducible IL-6 promoter"
},
{
"start": 70,
"end": 82,
"label": "DNA",
"value": "DNA fragment"
},
{
"start": 95,
"end": 106,
"l... |
en | Two nuclear factor NF-IL6 ( positions -153 to -145 and -83 to -75 ) and one nuclear factor NF-kappa B ( positions -72 to -63 ) motifs are present within this fragment . | [
{
"start": 4,
"end": 25,
"label": "protein",
"value": "nuclear factor NF-IL6"
},
{
"start": 38,
"end": 50,
"label": "DNA",
"value": "-153 to -145"
},
{
"start": 76,
"end": 133,
"label": "DNA",
"value": "nuclear factor NF-kappa B ( positions -72 to -63 ) motifs... |
en | Site-directed mutagenesis of one or more of these motifs within the IL-6 promoter demonstrated that each has positive regulatory activity and that they could act in a function- and orientation-independent manner . | [
{
"start": 68,
"end": 72,
"label": "protein",
"value": "IL-6"
}
] |
en | Deletion of all three elements abolished inducibility of IL-6 promoter activity by both LAM and LPS . | [
{
"start": 57,
"end": 70,
"label": "DNA",
"value": "IL-6 promoter"
},
{
"start": 88,
"end": 91,
"label": "protein",
"value": "LAM"
}
] |
en | We conclude that the NF-IL6 and NF-kappa B sites mediate IL-6 induction in response to both LPS and LAM , acting as bacterial or mycobacterial response elements . | [
{
"start": 21,
"end": 48,
"label": "DNA",
"value": "NF-IL6 and NF-kappa B sites"
},
{
"start": 57,
"end": 61,
"label": "protein",
"value": "IL-6"
},
{
"start": 100,
"end": 103,
"label": "protein",
"value": "LAM"
},
{
"start": 116,
"end": 160,
"... |
en | Regulation of CD14 expression during monocytic differentiation induced with 1 alpha , 25-dihydroxyvitamin D3 . | [
{
"start": 14,
"end": 18,
"label": "protein",
"value": "CD14"
}
] |
en | CD14 , a monocyte/macrophage receptor for the complex of LPS and LPS binding protein , is a differentiation marker for the monocyte/macrophage lineage . | [
{
"start": 0,
"end": 4,
"label": "protein",
"value": "CD14"
},
{
"start": 9,
"end": 37,
"label": "protein",
"value": "monocyte/macrophage receptor"
},
{
"start": 65,
"end": 84,
"label": "protein",
"value": "LPS binding protein"
},
{
"start": 123,
"... |
en | We have analyzed the regulation of CD14 expression during 1 alpha , 25-dihydroxyvitamin D3 ( VitD3 ) -induced monocytic differentiation . | [
{
"start": 35,
"end": 39,
"label": "protein",
"value": "CD14"
}
] |
en | Using FACS , Northern blotting , and nuclear run-on analyses , we demonstrate that the up-regulation of CD14 expression during monocytic cell maturation is regulated mainly at the level of gene transcription , and that new protein synthesis is required for CD14 induction . | [
{
"start": 104,
"end": 108,
"label": "protein",
"value": "CD14"
},
{
"start": 257,
"end": 261,
"label": "protein",
"value": "CD14"
}
] |
en | We have recently cloned the CD14 5 ' upstream sequence and demonstrated its tissue-specific promoter activity . | [
{
"start": 28,
"end": 54,
"label": "DNA",
"value": "CD14 5 ' upstream sequence"
},
{
"start": 76,
"end": 100,
"label": "DNA",
"value": "tissue-specific promoter"
}
] |
en | Using stable transfection of the monocytoid U937 cell line with a series of deletion mutants of the CD14 5 ' upstream sequence coupled to a reporter gene construct , we show that bp -128 to -70 is the critical region for the induction of CD14 expression . | [
{
"start": 33,
"end": 58,
"label": "cell_line",
"value": "monocytoid U937 cell line"
},
{
"start": 100,
"end": 126,
"label": "DNA",
"value": "CD14 5 ' upstream sequence"
},
{
"start": 179,
"end": 193,
"label": "DNA",
"value": "bp -128 to -70"
},
{
"sta... |
en | This region contains two binding sites for the Sp1 transcription factor . | [
{
"start": 25,
"end": 38,
"label": "DNA",
"value": "binding sites"
},
{
"start": 47,
"end": 71,
"label": "protein",
"value": "Sp1 transcription factor"
}
] |
en | A 3-bp mutation at the distal Sp1-binding site not only eliminates Sp1 interaction , but also abolishes most of the VitD3 induction of CD14 expression . | [
{
"start": 30,
"end": 46,
"label": "DNA",
"value": "Sp1-binding site"
},
{
"start": 67,
"end": 70,
"label": "protein",
"value": "Sp1"
},
{
"start": 135,
"end": 139,
"label": "protein",
"value": "CD14"
}
] |
en | Electrophoretic mobility shift analysis does not detect a direct interaction of the CD14 distal Sp1-binding site with the vitamin D3 receptor and its partner , the retinoid X receptor . | [
{
"start": 84,
"end": 88,
"label": "protein",
"value": "CD14"
},
{
"start": 96,
"end": 112,
"label": "DNA",
"value": "Sp1-binding site"
},
{
"start": 122,
"end": 141,
"label": "protein",
"value": "vitamin D3 receptor"
},
{
"start": 164,
"end": 183,... |
en | These data demonstrate that VitD3 induces CD14 indirectly through some intermediary factor , and suggest a critical role for Sp1 in this process . | [
{
"start": 42,
"end": 46,
"label": "protein",
"value": "CD14"
},
{
"start": 71,
"end": 90,
"label": "protein",
"value": "intermediary factor"
},
{
"start": 125,
"end": 128,
"label": "protein",
"value": "Sp1"
}
] |
en | DNA-binding and transcriptional regulatory properties of hepatic leukemia factor ( HLF ) and the t ( 17 ; 19 ) acute lymphoblastic leukemia chimera E2A-HLF . | [
{
"start": 57,
"end": 80,
"label": "protein",
"value": "hepatic leukemia factor"
},
{
"start": 83,
"end": 86,
"label": "protein",
"value": "HLF"
},
{
"start": 111,
"end": 155,
"label": "protein",
"value": "acute lymphoblastic leukemia chimera E2A-HLF"
}
] |
en | The t ( 17 ; 19 ) translocation in acute lymphoblastic leukemias results in creation of E2A-hepatic leukemia factor ( HLF ) chimeric proteins that contain the DNA-binding and protein dimerization domains of the basic leucine zipper ( bZIP ) protein HLF fused to a portion of E2A proteins with transcriptional activation ... | [
{
"start": 4,
"end": 17,
"label": "DNA",
"value": "t ( 17 ; 19 )"
},
{
"start": 88,
"end": 115,
"label": "protein",
"value": "E2A-hepatic leukemia factor"
},
{
"start": 118,
"end": 121,
"label": "protein",
"value": "HLF"
},
{
"start": 124,
"end": 1... |
en | An in vitro binding site selection procedure was used to determine DNA sequences preferentially bound by wild-type HLF and chimeric E2A-HLF proteins isolated from various t ( 17 ; 19 ) -bearing leukemias . | [
{
"start": 105,
"end": 118,
"label": "protein",
"value": "wild-type HLF"
},
{
"start": 123,
"end": 139,
"label": "protein",
"value": "chimeric E2A-HLF"
},
{
"start": 171,
"end": 203,
"label": "cell_line",
"value": "t ( 17 ; 19 ) -bearing leukemias"
}
] |
en | All were found to selectively bind the consensus sequence 5'-GTTACGTAAT-3 ' with high affinity . | [
{
"start": 39,
"end": 57,
"label": "DNA",
"value": "consensus sequence"
}
] |
en | Wild-type and chimeric HLF proteins also bound closely related sites identified previously for bZIP proteins of both the proline -and acidic amino acid-rich ( PAR ) and C/EBP subfamilies ; however , E2A-HLF proteins were significantly less tolerant of certain deviations from the HLF consensus binding site . | [
{
"start": 14,
"end": 35,
"label": "protein",
"value": "chimeric HLF proteins"
},
{
"start": 95,
"end": 108,
"label": "protein",
"value": "bZIP proteins"
},
{
"start": 121,
"end": 128,
"label": "protein",
"value": "proline"
},
{
"start": 159,
"end"... |
en | These differences were directly attributable to loss of an HLF ancillary DNA-binding domain in all E2A-HLF chimeras and were further exacerbated by a zipper mutation in one isolate . | [
{
"start": 59,
"end": 91,
"label": "DNA",
"value": "HLF ancillary DNA-binding domain"
},
{
"start": 99,
"end": 115,
"label": "protein",
"value": "E2A-HLF chimeras"
}
] |
en | Both wild-type and chimeric HLF proteins displayed transcriptional activator properties in lymphoid and nonlymphoid cells on reporter genes containing HLF or C/EBP consensus binding sites . | [
{
"start": 5,
"end": 14,
"label": "protein",
"value": "wild-type"
},
{
"start": 19,
"end": 40,
"label": "protein",
"value": "chimeric HLF proteins"
},
{
"start": 51,
"end": 76,
"label": "protein",
"value": "transcriptional activator"
},
{
"start": 91,
... |
en | But on reporter genes with nonoptimal binding sites , their transcriptional properties diverged and E2A-HLF competitively inhibited activation by wild-type PAR proteins . | [
{
"start": 7,
"end": 21,
"label": "DNA",
"value": "reporter genes"
},
{
"start": 27,
"end": 51,
"label": "DNA",
"value": "nonoptimal binding sites"
},
{
"start": 100,
"end": 107,
"label": "protein",
"value": "E2A-HLF"
},
{
"start": 146,
"end": 168,... |
en | These findings establish a spectrum of binding site-specific transcriptional properties for E2A-HLF which may preferentially activate expression of select subordinate genes as a homodimer and potentially antagonize expression of others through heteromeric interactions . | [
{
"start": 92,
"end": 99,
"label": "protein",
"value": "E2A-HLF"
}
] |
en | ZAP-70 tyrosine kinase , CD45 , and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction . | [
{
"start": 0,
"end": 22,
"label": "protein",
"value": "ZAP-70 tyrosine kinase"
},
{
"start": 25,
"end": 29,
"label": "protein",
"value": "CD45"
},
{
"start": 36,
"end": 51,
"label": "protein",
"value": "T cell receptor"
}
] |
en | Several mammalian responses to UV irradiation , including the activation of NF-kappa B , are believed to involve tyrosine phosphorylation . | [
{
"start": 76,
"end": 86,
"label": "protein",
"value": "NF-kappa B"
}
] |
en | UV irradiation and H2O2 treatment of T lymphocytes induce protein tyrosine phosphorylation and Ca2+ signals similar to those observed following biological stimulation . | [
{
"start": 37,
"end": 50,
"label": "cell_type",
"value": "T lymphocytes"
}
] |
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