smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
COS(=O)(=O)C#CC(N)=N
COS(=O)(=O)C#CC(=N)N
false
CCC(C)(C)CCC(C)C
162.17
35.6189
-1.14053
4
2
16
93.24
CCS(=O)(=O)CC(=C)C=C
C=CC(=C)CS(=O)(=O)CC
false
CCC(C)CC(C)(C)CC
160.238
43.6648
1.1633
2
0
22
34.14
COCC1=CSC(=N)N1C
COCc1csc(=N)n1C
false
CCCC1CCC(C)C1C
N=c1[nH]ccs1
158.226
39.8577
0.71247
4
1
20
38.01
CN1CS(=O)(=O)C1C1CN1
CN1CS(=O)(=O)C1C1CN1
true
CC1CC(C)(C)C1C1CC1
O=S1(=O)CNC1C1CN1
162.214
37.1285
-1.398
4
1
20
59.32
NS(=O)(=O)C1=CC=CC1O
NS(=O)(=O)C1=CC=CC1O
true
CC1CCCC1C(C)(C)C
C1=CCC=C1
161.182
36.337
-0.9105
3
2
17
80.39
OC1CCC=CS(=O)(=O)C1
O=S1(=O)C=CCCC(O)C1
false
CC1CCCCC(C)(C)C1
O=S1(=O)C=CCCCC1
162.21
38.1676
0.0696
3
1
20
54.37
ClC1=CC=C(NN=C)N=C1
C=NNc1ccc(Cl)cn1
false
CCCC1CCC(C)CC1
c1ccncc1
155.588
42.4187
1.7625
3
1
16
37.28
NC1CC1C1=CSC(N)=C1
Nc1cc(C2CC2N)cs1
false
CC1CCC(C2CC2C)C1
c1cc(C2CC2)cs1
154.238
44.0648
1.1449
3
2
20
52.04
CC(=O)N=C1NSC(C)=N1
CC(=O)N=c1nc(C)s[nH]1
false
CC(C)CC1CCC(C)C1
N=c1ncs[nH]1
157.198
37.4457
0.22682
3
1
17
58.11
NC1C(O)C2=C(N)SC=C12
Nc1scc2c1C(O)C2N
false
CC1CCC2C(C)C(C)C12
c1scc2c1CC2
156.21
40.6196
0.3771
4
3
18
72.27
CC(=O)C1=C(C)SC=C1Cl
CC(=O)c1c(Cl)csc1C
false
CC(C)C1C(C)CCC1C
c1ccsc1
174.652
44.0705
2.91252
2
0
17
17.07
NC=CS(=O)(=O)C#CC#N
N#CC#CS(=O)(=O)C=CN
false
CCCCC(C)(C)CCC
156.166
35.6362
-0.68442
4
1
14
83.95
CCNS(=O)(=O)C=CCC
CCC=CS(=O)(=O)NCC
false
CCCCC(C)(C)CCC
163.242
42.0275
0.8494
2
1
23
46.17
CCC1CNS(=O)(=O)NC1
CCC1CNS(=O)(=O)NC1
true
CCC1CCC(C)(C)CC1
O=S1(=O)NCCCN1
164.23
38.7062
-0.5498
2
2
22
58.2
CC1=CC(=O)N(N1)C(N)=S
Cc1cc(=O)n(C(N)=S)[nH]1
false
CC1CC(C)C(C(C)C)C1
O=c1cc[nH][nH]1
157.198
41.9731
-0.42348
3
2
17
63.81
CC(NCS(N)(=O)=O)C#C
C#CC(C)NCS(N)(=O)=O
false
CCC(C)CCC(C)(C)C
162.214
39.4049
-1.1563
3
2
20
72.19
C1CC11CC2=CSC=C2O1
c1scc2c1CC1(CC1)O2
false
C1CC2CC3(CC3)CC2C1
c1scc2c1CC1(CC1)O2
152.218
40.616
2.2156
2
0
18
9.23
CC=CC(C)C1=NSC=N1
CC=CC(C)c1ncsn1
false
CCCC(C)C1CCCC1
c1ncsn1
154.238
43.138
2.2177
3
0
20
25.78
CC(O)C1=CC(CO)=NS1
CC(O)c1cc(CO)ns1
false
CCC1CCC(C(C)C)C1
c1cnsc1
159.21
38.6706
0.6887
4
2
19
53.35
CN=C1NC=C(Cl)C(C)=N1
CN=c1nc(C)c(Cl)c[nH]1
false
CCC1CCC(C)C(C)C1
N=c1nccc[nH]1
157.604
39.8217
0.90202
2
1
18
41.04
CNC1=C(CO)SC=C1Cl
CNc1c(Cl)csc1CO
false
CCC1CCC(C)C1CC
c1ccsc1
177.656
44.7985
1.9355
3
2
18
32.26
CN1SC(C#N)=C(C)C1=O
Cc1c(C#N)sn(C)c1=O
false
CCC1CC(C)C(C)C1C
O=c1ccs[nH]1
154.194
39.012
0.6269
4
0
16
45.79
CN1SC(=O)C=C1N1CC1
Cn1sc(=O)cc1N1CC1
false
CC1CC(C)C(C2CC2)C1
O=c1cc(N2CC2)[nH]s1
156.21
41.773
0.2668
4
0
18
25.01
NC1CC1C1CN1C(N)=S
NC(=S)N1CC1C1CC1N
false
CC(C)C1CC1C1CC1C
C1CC1C1CN1
157.242
43.3618
-0.7386
2
2
21
55.05
CC1=C(C)C(Cl)=C(N1)C=C
C=Cc1[nH]c(C)c(C)c1Cl
false
CCC1CC(C)C(C)C1C
c1cc[nH]c1
155.628
45.3677
2.92794
0
1
20
15.79
CN1CCCN(O)C(=S)N1
CN1CCCN(O)C(=S)N1
true
CC1CCCC(C)C(C)C1
S=C1NCCCNN1
161.23
41.4732
-0.1974
3
2
21
38.74
O=S1(=O)C=CNCC1C#N
N#CC1CNC=CS1(=O)=O
false
CCC1CCCCC1(C)C
O=S1(=O)C=CNCC1
158.182
35.4635
-0.63222
4
1
16
69.96
O=S(=O)(C#C)N1CCCO1
C#CS(=O)(=O)N1CCCO1
false
CCC(C)(C)C1CCCC1
C1CNOC1
161.182
35.0278
-0.4558
3
0
17
46.61
O=C1COS(=O)(=O)C1C#C
C#CC1C(=O)COS1(=O)=O
false
CCC1C(C)CCC1(C)C
O=C1COS(=O)(=O)C1
160.15
32.4998
-1.0827
4
0
14
60.44
OS(=O)(=O)CC1(CN1)C#C
C#CC1(CS(=O)(=O)O)CN1
false
CCC1(CC(C)(C)C)CC1
C1CN1
161.182
35.9823
-1.1506
3
2
17
76.31
OCC12CC1S(=O)(=O)C=C2
O=S1(=O)C=CC2(CO)CC21
false
CCC12CCC(C)(C)C1C2
O=S1(=O)C=CC2CC21
160.194
35.9836
-0.3205
3
1
18
54.37
CC1=C(SN=C1C=O)C#C
C#Cc1snc(C=O)c1C
false
CCC1CCC(CC)C1C
c1cnsc1
151.19
40.1735
1.24532
3
0
15
29.96
CCNC(=S)NC1CC1C
CCNC(=S)NC1CC1C
true
CCCC(C)CC1CC1C
C1CC1
158.27
46.9794
0.8788
1
2
24
24.06
CN(C1CC1)C1=CN=NS1
CN(c1cnns1)C1CC1
false
CC(C1CCCC1)C1CC1
c1nnsc1NC1CC1
155.226
41.334
1.1367
4
0
19
29.02
CC1C=CC2=C(C)SN=C12
Cc1snc2c1C=CC2C
false
CC1CCC2C(C)CCC12
C1=Cc2csnc2C1
151.234
44.3
2.58182
2
0
19
12.89
CC1CC(=N)N(N)S1(=O)=O
CC1CC(=N)N(N)S1(=O)=O
true
CC1CC(C)C(C)(C)C1C
N=C1CCS(=O)(=O)N1
163.202
36.7519
-0.73863
4
2
19
87.25
NC(=S)N1C(CO)C1C=C
C=CC1C(CO)N1C(N)=S
false
CCC1C(CC)C1C(C)C
C1CN1
158.226
43.4832
-0.5389
2
2
20
49.26
COC1=C(C)SC(=N1)C#C
C#Cc1nc(OC)c(C)s1
false
CCC1CC(C)C(CC)C1
c1cscn1
153.206
41.338
1.44142
3
0
17
22.12
COC(=C)S(=O)(=O)C1CN1
C=C(OC)S(=O)(=O)C1CN1
false
CCC(C)C(C)(C)C1CC1
C1CN1
163.198
36.8595
-0.5519
4
1
19
65.31
CN1OS(=O)(=O)CCN=C1
CN1C=NCCS(=O)(=O)O1
false
CC1CCCCC(C)(C)C1
O=S1(=O)CCN=CNO1
164.186
35.9938
-0.7785
5
0
18
58.97
CC(C)S(=O)(=O)C(C)=NO
CC(=NO)S(=O)(=O)C(C)C
false
CCC(C)C(C)(C)C(C)C
165.214
38.9513
0.6172
4
1
21
66.73
OCCC1=C(Cl)C=C(O)N1
OCCc1[nH]c(O)cc1Cl
false
CCCC1CC(C)CC1C
c1cc[nH]c1
161.588
38.2573
0.9085
2
3
18
56.25
O=CN1C=CC2=CSC=C12
O=Cn1ccc2cscc21
false
CCC1CCC2CCCC12
c1cc2cscc2[nH]1
151.19
41.9635
1.7411
3
0
15
22
CNS(=O)(=O)C(C)=NOC
CNS(=O)(=O)C(C)=NOC
true
CCCC(C)C(C)(C)CC
166.202
38.0975
-0.4846
4
1
20
67.76
CC(=O)C#CC1=CC=NS1
CC(=O)C#Cc1ccns1
false
CC(C)CCC1CCCC1
c1cnsc1
151.19
39.673
1.0836
3
0
15
29.96
CN(C)C1=CC(Cl)=C(C)O1
Cc1oc(N(C)C)cc1Cl
false
CC(C)C1CC(C)C(C)C1
c1ccoc1
159.616
42.782
2.30742
2
0
20
16.38
CC1=NNS(=O)(=O)CNC1
CC1=NNS(=O)(=O)CNC1
true
CC1CCCC(C)(C)CC1
O=S1(=O)CNCC=NN1
163.202
38.0342
-1.1576
4
2
19
70.56
CC1ON=CCNS1(=O)=O
CC1ON=CCNS1(=O)=O
true
CC1CCCCCC1(C)C
O=S1(=O)CON=CCN1
164.186
35.9615
-0.7322
4
1
18
67.76
CCOCC1=NC=C(N)S1
CCOCc1ncc(N)s1
false
CCCCC1CCC(C)C1
c1cscn1
158.226
41.8564
1.2618
4
1
20
48.14
CC(C)CCNNC(N)=S
CC(C)CCNNC(N)=S
true
CC(C)CCCCC(C)C
161.274
47.3788
0.3703
2
3
25
50.08
CON1CC(C)(C)NC1=S
CON1CC(C)(C)NC1=S
true
CCC1CC(C)(C)CC1C
S=C1NCCN1
160.242
43.5277
0.5165
2
1
22
24.5
CC(NC(N)=S)C(C)(C)N
CC(NC(N)=S)C(C)(C)N
true
CC(C)CC(C)C(C)(C)C
161.274
47.6495
-0.0546
2
3
25
64.07
NCC1=C(Cl)C=NC=C1Cl
NCc1c(Cl)cncc1Cl
false
CCC1C(C)CCCC1C
c1ccncc1
177.034
42.1484
1.8471
2
1
16
38.91
CC(CO)C1=CSC(N)=N1
CC(CO)c1csc(N)n1
false
CCC(C)C1CCC(C)C1
c1cscn1
158.226
42.0272
0.8211
4
2
20
59.14
CC1=C(O)SC(=C1)N1CC1
Cc1cc(N2CC2)sc1O
false
CC1CC(C2CC2)CC1C
c1csc(N2CC2)c1
155.222
42.9338
1.58212
3
1
19
23.24
CCC1NC(=N)NS1(=O)=O
CCC1NC(=N)NS1(=O)=O
true
CCC1CC(C)CC1(C)C
N=C1NCS(=O)(=O)N1
163.202
36.9969
-0.82013
3
3
19
82.05
O=S1(=O)CN2CC1CCC2
O=S1(=O)CN2CCCC1C2
false
CC1(C)CC2CCCC1C2
O=S1(=O)CN2CCCC1C2
161.226
38.3818
-0.1633
3
0
21
37.38
CC(=C)C1OS(=O)(=O)C1O
C=C(C)C1OS(=O)(=O)C1O
false
CC(C)C1CC(C)(C)C1C
O=S1(=O)CCO1
164.182
34.6136
-0.3905
4
1
18
63.6
O=C1C(=CCS1(=O)=O)C#C
C#CC1=CCS(=O)(=O)C1=O
false
CCC1CCC(C)(C)C1C
O=C1C=CCS1(=O)=O
156.162
35.7098
-0.499
3
0
14
51.21
ONC(=S)N1C=CCC1=C
C=C1CC=CN1C(=S)NO
false
CCC(C)C1CCCC1C
C=C1CC=CN1
156.21
42.2562
0.9832
2
2
18
35.5
NC(=N)C=CS(=O)(=O)C=C
C=CS(=O)(=O)C=CC(=N)N
false
CCC(C)(C)CCC(C)C
160.198
40.1709
-0.00563
3
2
18
84.01
CC1C(N)S(=O)(=O)NC1=N
CC1C(=N)NS(=O)(=O)C1N
false
CC1CC(C)(C)C(C)C1C
N=C1CCS(=O)(=O)N1
163.202
36.9216
-1.18243
4
3
19
96.04
CC1C2CC1N(N)C(=S)N2
CC1C2CC1N(N)C(=S)N2
true
CC1CC2CC(C1C)C2C
S=C1NC2CC(C2)N1
157.242
43.1171
-0.1728
2
2
21
41.29
OC1=C(SC=C1)C#CC=C
C=CC#Cc1sccc1O
false
CCCCC1CCCC1C
c1ccsc1
150.202
43.0588
1.9912
2
1
16
20.23
O=C1CC2CS(=O)(=O)C1N2
O=C1CC2CS(=O)(=O)C1N2
true
CC1CC2CC1C(C)(C)C2
O=C1CC2CS(=O)(=O)C1N2
161.182
34.1225
-1.3281
4
1
17
63.24
CC(N(C)C)C1=NSC=C1
CC(c1ccsn1)N(C)C
false
CC(C)C(C)C1CCCC1
c1cnsc1
156.254
44.216
1.7657
3
0
22
16.13
CC1=C(C=O)N=C(S1)C=C
C=Cc1nc(C=O)c(C)s1
false
CCC1CC(C)C(CC)C1
c1cscn1
153.206
42.3295
1.90702
3
0
17
29.96
CC1C2OC1(C)CS2(=O)=O
CC1C2OC1(C)CS2(=O)=O
true
CC1C2CC1(C)CC2(C)C
O=S1(=O)CC2CC1O2
162.21
36.2288
0.1659
3
0
20
43.37
CC(C)C1=NC(N)=C(O)S1
CC(C)c1nc(N)c(O)s1
false
CC(C)C1CC(C)C(C)C1
c1cscn1
158.226
42.2802
1.5543
4
2
20
59.14
CC1(C)C=CC2=C1SC=N2
CC1(C)C=Cc2ncsc21
false
CC1(C)CCC2CCCC21
C1=Cc2ncsc2C1
151.234
44.174
2.4475
2
0
19
12.89
CC1NC(=S)N(O)C=C1C
CC1=CN(O)C(=S)NC1C
false
CC1CC(C)C(C)CC1C
S=C1NC=CCN1
158.226
42.5782
0.858
2
2
20
35.5
CC=COC1=C(C)SC=C1
CC=COc1ccsc1C
false
CCCCC1CCCC1C
c1ccsc1
154.234
44.498
2.96892
2
0
20
9.23
N#CCC#CC1=NC=NS1
N#CCC#Cc1ncns1
false
CCCCCC1CCCC1
c1ncsn1
149.178
37.017
0.80328
4
0
13
49.57
NN1SC(=O)C2=C1CC=C2
Nn1sc(=O)c2c1CC=C2
false
CC1CC(C)C2CCCC12
O=c1s[nH]c2c1C=CC2
154.194
41.4674
0.1929
4
1
16
48.02
N=C1CS(=O)(=O)C(N1)C#N
N#CC1NC(=N)CS1(=O)=O
false
CCC1CC(C)CC1(C)C
N=C1CS(=O)(=O)CN1
159.17
34.0502
-1.16865
4
2
15
93.81
NS(=O)(=O)C1C2OC=CC12
NS(=O)(=O)C1C2C=COC21
false
CC(C)(C)C1C2CCCC21
C1=CC2CC2O1
161.182
34.3982
-0.8142
3
1
17
69.39
O=C1CNCC2=NSN=C12
O=C1CNCc2nsnc21
false
CC1CCCC2CCCC12
O=C1CNCc2nsnc21
155.182
35.9462
-0.176
5
1
15
54.88
COC(=NN)C1=CN=CS1
COC(=NN)c1cncs1
false
CCC(CC)C1CCCC1
c1cscn1
157.198
39.8474
0.4098
5
1
17
60.5
ON1CC2CN2CS1(=O)=O
O=S1(=O)CN2CC2CN1O
false
CC1CC2CC2CC1(C)C
O=S1(=O)CN2CC2CN1
164.186
32.7733
-1.3373
4
1
18
60.62
CNCC(C=O)S(C)(=O)=O
CNCC(C=O)S(C)(=O)=O
true
CCCC(CC)C(C)(C)C
165.214
38.6225
-1.1821
4
1
21
63.24
CC1=C(C)C=NNC(=S)N1
CC1=C(C)NC(=S)NN=C1
false
CC1CCCC(C)C(C)C1
S=C1NC=CC=NN1
155.226
45.7354
0.7438
2
2
19
36.42
CC1=C(Cl)C(CO)=NN1N
Cc1c(Cl)c(CO)nn1N
false
CCC1CC(C)C(C)C1C
c1cn[nH]c1
161.592
38.0472
0.05102
4
2
18
64.07
CC=C(C)OC1=NSC=C1
CC=C(C)Oc1ccsn1
false
CCC(C)CC1CCCC1
c1cnsc1
155.222
42.173
2.4456
3
0
19
22.12
CNC1=CC(C#C)=C(C)S1
C#Cc1cc(NC)sc1C
false
CCC1CC(C)C(CC)C1
c1ccsc1
151.234
46.5377
2.07952
2
1
19
12.03
CCC1=CSC2=C1NN=N2
CCc1csc2nn[nH]c12
false
CCC1CCC2CCCC12
c1cc2[nH]nnc2s1
153.21
41.1437
1.5818
3
1
17
41.57
COCCNS(=O)(=O)CN
COCCNS(=O)(=O)CN
true
CCCCCC(C)(C)CC
168.218
37.8529
-1.5316
4
2
22
81.42
CCN1N=CC(=C)NC1=S
C=C1C=NN(CC)C(=S)N1
false
CCC1CCC(C)CC1C
C=C1C=NNC(=S)N1
155.226
45.7457
0.6959
2
1
19
27.63
NC(CNS(N)(=O)=O)C#C
C#CC(N)CNS(N)(=O)=O
false
CCC(C)CCC(C)(C)C
163.202
37.9183
-2.26
3
3
19
98.21
N=CNCC1=CNSC1=O
N=CNCc1c[nH]sc1=O
false
CCCCC1CCCC1C
O=c1cc[nH]s1
157.198
40.5631
0.13307
3
3
17
68.74
CNN=CC1=CNC(=O)S1
CNN=Cc1c[nH]c(=O)s1
false
CCCCC1CCC(C)C1
O=c1[nH]ccs1
157.198
41.5934
-0.0103
4
2
17
57.25
C#CC1=NC2=C(S1)N=CO2
C#Cc1nc2ocnc2s1
false
CCC1CC2CCCC2C1
c1nc2scnc2o1
150.162
37.616
1.2656
4
0
12
38.92
CN=C1SN=CN1CC#N
CN=c1sncn1CC#N
false
CCCC1CCCC1CC
N=c1[nH]cns1
154.198
37.204
-0.00132
5
0
16
53.97
CC(=C)C1(C)CS(=O)(=O)C1
C=C(C)C1(C)CS(=O)(=O)C1
false
CC(C)C1(C)CC(C)(C)C1
O=S1(=O)CCC1
160.238
41.5748
0.9972
2
0
22
34.14
NN=C1CCCS(=O)(=O)N1
NN=C1CCCS(=O)(=O)N1
true
CCC1CCCC(C)(C)C1
N=C1CCCS(=O)(=O)N1
163.202
37.7789
-1.0282
4
2
19
84.55
CC(C=C)C1=C(O)SC=N1
C=CC(C)c1ncsc1O
false
CCC(C)C1CCCC1C
c1cscn1
155.222
42.3908
2.1382
3
1
19
33.12
CCC1(CN1C(N)=S)C#C
C#CC1(CC)CN1C(N)=S
false
CCC1(CC)CC1C(C)C
C1CN1
154.238
45.3464
0.3276
1
1
20
29.03
NC1=CC(Cl)=C(Cl)C(N)=N1
Nc1cc(Cl)c(Cl)c(N)n1
false
CC1CC(C)C(C)C(C)C1
c1ccncc1
178.022
43.0818
1.5528
3
2
15
64.93
CC(O)C1=NS(=O)(=O)N=C1
CC(O)C1=NS(=O)(=O)N=C1
true
CC(C)C1CCC(C)(C)C1
O=S1(=O)N=CC=N1
162.17
36.5276
-0.8626
3
1
16
79.09
CC1=NC(N)=C2SC=CN12
Cc1nc(N)c2sccn12
false
CC1CC(C)C2CCCC12
c1cn2cncc2s1
153.21
42.2184
1.28642
4
1
17
43.32
CC1CNC2=NSC(=O)N12
CC1CNc2nsc(=O)n21
false
CC1CCC2CCC(C)C12
O=c1snc2n1CCN2
157.198
39.5747
0.2913
5
1
17
46.92