smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
CN1C(=C)C(C)=NS1(=O)=O
C=C1C(C)=NS(=O)(=O)N1C
false
CC1CC(C)(C)C(C)C1C
C=C1C=NS(=O)(=O)N1
160.198
38.9318
0.1512
2
0
18
49.74
NCC#CCCS(N)(=O)=O
NCC#CCCS(N)(=O)=O
true
CCCCCCC(C)(C)C
162.214
39.4216
-1.3729
3
2
20
86.18
CC1CC1C1=NNSC1=O
CC1CC1c1n[nH]sc1=O
false
CC1CCCC1C1CC1C
O=c1s[nH]nc1C1CC1
156.21
39.2567
0.9548
3
1
18
45.75
CC(=O)C(C)=CS(C)(=O)=O
CC(=O)C(C)=CS(C)(=O)=O
true
CC(C)C(C)CC(C)(C)C
162.21
39.2818
0.5238
3
0
20
51.21
OC1=C2C(CC2=CS1)C=O
O=CC1Cc2csc(O)c21
false
CCC1CC2CCC(C)C12
c1scc2c1CC2
154.19
38.4928
1.2923
3
1
16
37.3
CCCC#CCNC(N)=S
CCCC#CCNC(N)=S
true
CCCCCCCC(C)C
156.254
47.4721
0.6231
1
2
22
38.05
S1C=C2C(=C1)C1=NSC=C21
c1scc2c1-c1csnc1-2
false
C1CC2C(C1)C1CCCC21
c1scc2c1-c1csnc1-2
165.242
44.421
2.852
3
0
13
12.89
O=C1SN(C=C1)N1CCC1
O=c1ccn(N2CCC2)s1
false
CC1CCC(C2CCC2)C1
O=c1ccn(N2CCC2)s1
156.21
41.147
0.2515
4
0
18
25.24
CCN1C=C2N=CSC2=N1
CCn1cc2ncsc2n1
false
CCC1CC2CCCC2C1
c1nc2c[nH]nc2s1
153.21
41.079
1.5127
4
0
17
30.71
CC1CN2C1=C(N)SC2=O
CC1Cn2c1c(N)sc2=O
false
CC1CC(C)C2C(C)CC12
O=c1scc2n1CC2
156.21
41.4064
0.6091
4
1
18
48.02
COS(=O)(=O)C#CCCO
COS(=O)(=O)C#CCCO
true
CCCCCC(C)(C)CC
164.182
35.4076
-0.6941
4
1
18
63.6
O=CCC1=C2COC2=NS1
O=CCc1snc2c1CO2
false
CCCC1CCC2CCC12
c1snc2c1CO2
155.178
36.214
0.7769
4
0
15
39.19
CC1=CC2=C(O1)C(C)=CS2
Cc1cc2scc(C)c2o1
false
CC1CC2CCC(C)C2C1
c1cc2sccc2o1
152.218
43.565
3.11114
2
0
18
13.14
CC1CNS(=O)(=O)C=NN1
CC1CNS(=O)(=O)C=NN1
true
CC1CCCC(C)(C)CC1
O=S1(=O)C=NNCCN1
163.202
38.0122
-1.1592
4
2
19
70.56
NCC1CCCS(=O)(=O)N1
NCC1CCCS(=O)(=O)N1
true
CCC1CCCC(C)(C)C1
O=S1(=O)CCCCN1
164.23
38.9989
-0.9731
3
2
22
72.19
CNC1=NSC(C#C)=C1C
C#Cc1snc(NC)c1C
false
CCC1CCC(CC)C1C
c1cnsc1
152.222
44.3327
1.47452
3
1
18
24.92
CCC1=C2CCN2C=C1Cl
CCc1c(Cl)cn2c1CC2
false
CCC1C(C)CC2CCC21
c1cc2n(c1)CC2
155.628
42.524
2.26
1
0
20
4.93
CN1CC2=C(CO)SC=C12
CN1Cc2c1csc2CO
false
CCC1CCC2C(C)CC12
c1scc2c1CN2
155.222
42.3488
1.1902
3
1
19
23.47
C=NN1SC=C(C#C)C1=N
C#Cc1csn(N=C)c1=N
false
CCC1CCC(CC)C1C
N=c1ccs[nH]1
151.194
41.0457
0.47407
4
1
15
41.14
CC=CC1=NSC(O)=C1C
CC=Cc1nsc(O)c1C
false
CCCC1CCC(C)C1C
c1cnsc1
155.222
43.2238
2.19022
3
1
19
33.12
CC(C#C)S(=O)(=O)OC=C
C#CC(C)S(=O)(=O)OC=C
false
CCCC(C)(C)C(C)CC
160.194
38.4968
0.498
3
0
18
43.37
CC(=C)C1CN1NC(N)=S
C=C(C)C1CN1NC(N)=S
false
CC(C)CC1CC1C(C)C
C1CN1
157.242
45.2291
-0.0051
2
2
21
41.06
O=C1CCCNCS1(=O)=O
O=C1CCCNCS1(=O)=O
true
CC1CCCCCC1(C)C
O=C1CCCNCS1(=O)=O
163.198
36.0305
-0.7313
4
1
19
63.24
CN1CC1CC1=NSC=N1
CN1CC1Cc1ncsn1
false
CC1CC1CC1CCCC1
c1nc(CC2CN2)ns1
155.226
40.031
0.3946
4
0
19
28.79
O=CC12CCC(N1)S2(=O)=O
O=CC12CCC(N1)S2(=O)=O
true
CCC12CCC(C1)C2(C)C
O=S1(=O)C2CCC1N2
161.182
33.8725
-0.9805
4
1
17
63.24
N=CN1C(=N)C=CS1(=O)=O
N=CN1C(=N)C=CS1(=O)=O
true
CCC1C(C)CCC1(C)C
N=C1C=CS(=O)(=O)N1
159.17
36.4092
-0.27016
4
2
15
85.08
C=C1CCOC2=C1SC=N2
C=C1CCOc2ncsc21
false
CC1CCCC2CCCC12
C=C1CCOc2ncsc21
153.206
41.26
1.9388
3
0
17
22.12
OCC1=NSN=C1CC#C
C#CCc1nsnc1CO
false
CCCC1CCCC1CC
c1cnsn1
154.194
38.3688
0.2061
4
1
16
46.01
NC(=S)N1C=CCC1C=O
NC(=S)N1C=CCC1C=O
true
CCC1CCCC1C(C)C
C1=CNCC1
156.21
42.2334
0.0169
2
1
18
46.33
CN1C(=S)N2CC2C11CC1
CN1C(=S)N2CC2C12CC2
false
CC1C2CC2C2(CC2)C1C
S=C1NC2(CC2)C2CN12
154.238
42.82
0.4335
1
0
20
6.25
CC12CNC(=S)N1CC2=O
CC12CNC(=S)N1CC2=O
true
CC1CCC2(C)C(C)CC12
O=C1CN2C(=S)NCC12
156.21
40.7187
-0.4821
2
1
18
32.34
CC1=C2CNN=CC2=CS1
Cc1scc2c1CNN=C2
false
CC1CCC2CCCCC12
C1=NNCc2cscc21
152.222
43.4897
1.49362
3
1
18
24.39
OC1CS(=O)(=O)NN2CC12
O=S1(=O)CC(O)C2CN2N1
false
CC1CC(C)(C)CC2CC12
O=S1(=O)CCC2CN2N1
164.186
33.4233
-2.1205
4
2
18
69.41
COC1=C(CN)C=C(O)S1
COc1sc(O)cc1CN
false
CCC1CC(C)CC1CC
c1ccsc1
159.21
40.4272
0.921
4
2
19
55.48
CC(C#N)C1=CSC(=O)N1
CC(C#N)c1csc(=O)[nH]1
false
CCC(C)C1CCC(C)C1
O=c1[nH]ccs1
154.194
38.9677
1.06348
3
1
16
56.65
NN1C=NC2=C1SC=C2Cl
Nn1cnc2c(Cl)csc21
false
CC1CCC2C(C)CCC12
c1nc2ccsc2[nH]1
173.628
42.7704
1.465
4
1
14
43.84
NC(=S)NCCCCCO
NC(=S)NCCCCCO
true
CCCCCCCC(C)C
162.258
45.7249
-0.0178
2
3
24
58.28
CC1CS(=O)(=O)C(C)=CO1
CC1=COC(C)CS1(=O)=O
false
CC1CCC(C)C(C)(C)C1
O=S1(=O)C=COCC1
162.21
38.0908
0.6812
3
0
20
43.37
CC=CCCCS(C)(=O)=O
CC=CCCCS(C)(=O)=O
true
CCCCCCC(C)(C)C
162.254
43.7588
1.3873
2
0
24
34.14
CC(=C)C1=C(C)SC(=O)N1
C=C(C)c1[nH]c(=O)sc1C
false
CC1CC(C)C(C(C)C)C1
O=c1[nH]ccs1
155.222
44.3847
1.77792
2
1
19
32.86
OS(=O)(=O)CCC(=C)C=O
C=C(C=O)CCS(=O)(=O)O
false
CCC(C)CCC(C)(C)C
164.182
36.2366
0.0194
3
1
18
71.44
NS(=O)(=O)CCCC1CN1
NS(=O)(=O)CCCC1CN1
true
CC(C)(C)CCCC1CC1
C1CN1
164.23
38.9989
-0.9731
3
2
22
82.1
CC(C)OC1=C(O)SC=N1
CC(C)Oc1ncsc1O
false
CC(C)CC1CCCC1C
c1cscn1
159.21
39.5428
1.6359
4
1
19
42.35
C=C1C(=O)CCOS1(=O)=O
C=C1C(=O)CCOS1(=O)=O
true
CC1CCCC(C)(C)C1C
C=C1C(=O)CCOS1(=O)=O
162.166
33.6358
-0.1807
4
0
16
60.44
CC(O)(CN)C1=NC=CS1
CC(O)(CN)c1nccs1
false
CCC(C)(C)C1CCCC1
c1cscn1
158.226
40.7392
0.3093
4
2
20
59.14
OS(=O)(=O)C=C1CCCN1
O=S(=O)(O)C=C1CCCN1
false
CC(C)(C)CC1CCCC1
C=C1CCCN1
163.198
36.8683
0.099
3
2
19
66.4
CC1=C(O)NC(C#C)=C1Cl
C#Cc1[nH]c(O)c(C)c1Cl
false
CCC1CC(C)C(C)C1C
c1cc[nH]c1
155.584
40.1395
1.66342
1
2
16
36.02
NCC=CC1=NSC=C1O
NCC=Cc1nscc1O
false
CCCCC1CCCC1C
c1cnsc1
156.21
41.8672
0.8206
4
2
18
59.14
NC=C1CS(=O)(=O)NC1=N
N=C1NS(=O)(=O)CC1=CN
false
CCC1CC(C)(C)CC1C
C=C1CS(=O)(=O)NC1=N
161.186
36.9196
-1.26073
4
3
17
96.04
CC1=C(O)C(=N)N(S1)N=C
C=Nn1sc(C)c(O)c1=N
false
CCC1CC(C)C(C)C1C
N=c1ccs[nH]1
157.198
39.5125
0.50679
5
2
17
61.37
CS(=O)(=O)N1CC1C(N)=O
CS(=O)(=O)N1CC1C(N)=O
true
CC(C)C1CC1C(C)(C)C
C1CN1
164.186
34.5322
-1.8845
3
1
18
80.24
CCC1(C)CC2=CSN=C12
CCC1(C)Cc2csnc21
false
CCC1(C)CC2CCCC21
c1snc2c1CC2
153.25
43.461
2.3669
2
0
21
12.89
CS(=O)(=O)NCC1CCN1
CS(=O)(=O)NCC1CCN1
true
CC(C)(C)CCC1CCC1
C1CNC1
164.23
39.2542
-1.1025
3
2
22
58.2
CC1(O)CCCCS1(=O)=O
CC1(O)CCCCS1(=O)=O
true
CC1(C)CCCCC1(C)C
O=S1(=O)CCCCC1
164.226
38.2616
0.2936
3
1
22
54.37
CC=C1NS(=O)(=O)NC1C
CC=C1NS(=O)(=O)NC1C
true
CCC1CC(C)(C)CC1C
C=C1CNS(=O)(=O)N1
162.214
38.4102
-0.2837
2
2
20
58.2
CCC(=O)S(=O)(=O)C(C)O
CCC(=O)S(=O)(=O)C(C)O
true
CCC(C)C(C)(C)C(C)C
166.198
35.8986
-0.3239
4
1
20
71.44
NC1(CC1S(O)(=O)=O)C#C
C#CC1(N)CC1S(=O)(=O)O
false
CCC1(C)CC1C(C)(C)C
C1CC1
161.182
35.705
-1.0228
3
2
17
80.39
NC(=S)NC1=NCCC=C1
NC(=S)NC1=NCCC=C1
true
CC(C)CC1CCCCC1
C1=CCCN=C1
155.226
45.9801
0.178
2
2
19
50.41
CN1NCCCOS1(=O)=O
CN1NCCCOS1(=O)=O
true
CC1CCCCCC1(C)C
O=S1(=O)NNCCCO1
166.202
35.2545
-0.9121
4
1
20
58.64
OCCC1(O)CS(=O)(=O)C1
O=S1(=O)CC(O)(CCO)C1
false
CCCC1(C)CC(C)(C)C1
O=S1(=O)CCC1
166.198
35.3064
-1.4717
4
2
20
74.6
CC1=C(C#C)C(Cl)=CN1O
C#Cc1c(Cl)cn(O)c1C
false
CCC1C(C)CC(C)C1C
c1cc[nH]c1
155.584
39.2985
1.66852
2
1
16
25.16
NC1=C2CCCC2=C(O)S1
Nc1sc(O)c2c1CCC2
false
CC1CC(C)C2CCCC12
c1scc2c1CCC2
155.222
42.4212
1.5246
3
2
19
46.25
OC1=C2C(CC2=CS1)C#N
N#CC1Cc2csc(O)c21
false
CCC1CC2CCC(C)C12
c1scc2c1CC2
151.19
38.0418
1.61698
3
1
15
44.02
N=CC=C1N=CNS1(=O)=O
N=CC=C1N=CNS1(=O)=O
true
CCCC1CCCC1(C)C
C=C1N=CNS1(=O)=O
159.17
37.4142
-0.56133
4
2
15
82.38
CC=CC1=C(C=O)N=CS1
CC=Cc1scnc1C=O
false
CCCC1CCCC1CC
c1cscn1
153.206
42.2095
1.9887
3
0
17
29.96
CC(O)C1=CC=C(Cl)C=N1
CC(O)c1ccc(Cl)cn1
false
CC1CCC(C(C)C)CC1
c1ccncc1
157.6
39.8808
1.7883
2
1
18
33.12
C=C1OC2CC2OS1(=O)=O
C=C1OC2CC2OS1(=O)=O
true
CC1CC2CC2CC1(C)C
C=C1OC2CC2OS1(=O)=O
162.166
32.4228
-0.0249
4
0
16
52.6
CN1SC=CC1=NNC=O
Cn1sccc1=NNC=O
false
CCCCC1CCCC1C
N=c1ccs[nH]1
157.198
38.0527
-0.3517
4
1
17
46.39
CN(C)CC(O)S(C)(=O)=O
CN(C)CC(O)S(C)(=O)=O
true
CC(C)CC(C)C(C)(C)C
167.23
39.4046
-1.089
4
1
23
57.61
CCCC1(C)CS(=O)(=O)N1
CCCC1(C)CS(=O)(=O)N1
true
CCCC1(C)CC(C)(C)C1
O=S1(=O)CCN1
163.242
40.2355
0.4782
2
1
23
46.17
CCC1=C(SC=N1)C(N)=N
CCc1ncsc1C(=N)N
false
CCC1CCCC1C(C)C
c1cscn1
155.226
42.5081
0.98957
3
2
19
62.76
C=CC1=CC2NC1S2(=O)=O
C=CC1=CC2NC1S2(=O)=O
true
CCC1CC2CC1C2(C)C
O=S1(=O)C2C=CC1N2
157.194
37.9115
-0.2174
3
1
17
46.17
CNCC(OC)S(C)(=O)=O
CNCC(OC)S(C)(=O)=O
true
CCCC(CC)C(C)(C)C
167.23
39.5675
-0.7771
4
1
23
55.4
CCC=CNS(=O)(=O)C=C
C=CS(=O)(=O)NC=CCC
false
CCCCCC(C)(C)CC
161.226
41.6835
0.973
2
1
21
46.17
CCCCNC(=S)N(C)C
CCCCNC(=S)N(C)C
true
CCCCCC(C)C(C)C
160.286
49.1957
1.2226
1
1
26
15.27
C=CC1=NNC(=S)N2CC12
C=CC1=NNC(=S)N2CC12
true
CCC1CCC(C)C2CC12
S=C1NN=CC2CN12
153.21
43.8597
0.1007
2
1
17
27.4
CCC1=C2C=CSC2=NN1
CCc1[nH]nc2sccc12
false
CCC1CCC2CCCC12
c1cc2c[nH]nc2s1
152.222
43.3487
2.1868
2
1
18
28.68
COC1C=CC2=C1SN=N2
COC1C=Cc2nnsc21
false
CCC1CCC2CCCC12
C1=Cc2nnsc2C1
154.194
38.693
1.2524
4
0
16
35.01
CC1=CSC2=C1CC(O)C2
Cc1csc2c1CC(O)C2
false
CC1CC2CCC(C)C2C1
c1cc2c(s1)CCC2
154.234
42.4708
1.51602
2
1
20
20.23
CCN(C)C1=CSN=C1C
CCN(C)c1csnc1C
false
CCC(C)C1CCCC1C
c1cnsc1
156.254
45.795
1.90762
3
0
22
16.13
CC1=CC=C(NC(N)=S)N1
Cc1ccc(NC(N)=S)[nH]1
false
CC(C)CC1CCC(C)C1
c1cc[nH]c1
155.226
45.9378
0.97862
1
3
19
53.84
NC1=CN=C(C=C1Cl)C#N
N#Cc1cc(Cl)c(N)cn1
false
CCC1CCC(C)C(C)C1
c1ccncc1
153.572
38.3744
1.18888
3
1
14
62.7
CS(=O)(=O)OCC=CC=C
C=CC=CCOS(C)(=O)=O
false
CCCCCCC(C)(C)C
162.21
40.1328
0.7048
3
0
20
43.37
O=CNN1CCCNC1=S
O=CNN1CCCNC1=S
true
CCCC1CCCCC1C
S=C1NCCCN1
159.214
41.1234
-0.7724
2
2
19
44.37
CCN(C=O)S(=O)(=O)CN
CCN(C=O)S(=O)(=O)CN
true
CCC(CC)C(C)(C)CC
166.202
36.4182
-1.2893
4
1
20
80.47
CC1C(C)(N)CNS1(=O)=O
CC1C(C)(N)CNS1(=O)=O
true
CC1C(C)(C)CCC1(C)C
O=S1(=O)CCCN1
164.23
38.9769
-0.9747
3
2
22
72.19
O=C1NC=C(S1)C=CC#C
C#CC=Cc1c[nH]c(=O)s1
false
CCCCC1CCC(C)C1
O=c1[nH]ccs1
151.19
42.8067
1.0828
2
1
15
32.86
CC(O)C(C=O)S(C)(=O)=O
CC(O)C(C=O)S(C)(=O)=O
true
CCC(C(C)C)C(C)(C)C
166.198
36.3766
-1.0207
4
1
20
71.44
CC1=CSC2=C1CNC=N2
Cc1csc2c1CNC=N2
false
CC1CCC2CCCCC12
C1=Nc2sccc2CN1
152.222
44.0477
1.81952
3
1
18
24.39
OC1=C(C=CS1)N1CCC1
Oc1sccc1N1CCC1
false
CC1CCCC1C1CCC1
c1cc(N2CCC2)cs1
155.222
42.8138
1.6638
3
1
19
23.47
CC1=C(Cl)C=NC2=C1NC2
Cc1c(Cl)cnc2c1NC2
false
CC1CCC2CCC2C1C
c1cnc2c(c1)NC2
154.6
41.3107
1.96892
2
1
17
24.92
CC(C)=CC1=C(Cl)C=CO1
CC(C)=Cc1occc1Cl
false
CC(C)CC1CCCC1C
c1ccoc1
156.612
43.043
3.3562
1
0
19
13.14
NCC(C1CO1)S(N)(=O)=O
NCC(C1CO1)S(N)(=O)=O
true
CCC(C1CC1)C(C)(C)C
C1CO1
166.202
35.6896
-1.999
4
2
20
98.71
CCN1C=COCS1(=O)=O
CCN1C=COCS1(=O)=O
true
CCC1CCCCC1(C)C
O=S1(=O)COC=CN1
163.198
36.3918
0.097
3
0
19
46.61
NC(=S)N1CC2=CON=C12
NC(=S)N1Cc2conc21
false
CC(C)C1CC2CCCC21
c1onc2c1CN2
155.182
39.4714
0.2382
3
1
15
55.29
CC1CN1C1=C(N)C=CS1
CC1CN1c1sccc1N
false
CC1CCCC1C1CC1C
c1csc(N2CC2)c1
154.238
45.5394
1.5388
3
1
20
29.03
COC(=O)C1=CSC(C)=N1
COC(=O)c1csc(C)n1
false
CCC(C)C1CCC(C)C1
c1cscn1
157.194
38.1905
1.23812
4
0
17
39.19
O=C1C2CC1CS(=O)(=O)C2
O=C1C2CC1CS(=O)(=O)C2
true
CC1C2CC1CC(C)(C)C2
O=C1C2CC1CS(=O)(=O)C2
160.194
35.2578
-0.38
3
0
18
51.21
NC1=CC=CC2=NSC=C12
Nc1cccc2nscc12
false
CC1CCCC2CCCC12
c1ccc2nscc2c1
150.206
44.0324
1.8785
3
1
16
38.91
CC1=C(O)N2C=CSC2=C1
Cc1cc2sccn2c1O
false
CC1CC2CCCC2C1C
c1cc2sccn2c1
153.206
41.6758
2.01482
3
1
17
24.64