smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
CC12CC(C1)CS(=O)(=O)O2
CC12CC(C1)CS(=O)(=O)O2
true
CC1(C)CC2CC(C)(C2)C1
O=S1(=O)CC2CC(C2)O1
162.21
36.0008
0.5151
3
0
20
43.37
CC(=C)C(=C)S(=O)(=O)C#C
C#CS(=O)(=O)C(=C)C(=C)C
false
CCC(C)(C)C(C)C(C)C
156.206
41.7068
1.0817
2
0
18
34.14
N=CNS(=O)(=O)C1CCN1
N=CNS(=O)(=O)C1CCN1
true
CCCC(C)(C)C1CCC1
C1CNC1
163.202
37.2469
-1.16773
4
3
19
82.05
CC(=O)C1CC(O)S1(=O)=O
CC(=O)C1CC(O)S1(=O)=O
true
CC(C)C1CC(C)C1(C)C
O=S1(=O)CCC1
164.182
34.0126
-0.9191
4
1
18
71.44
CCC1=C(O)NC(S1)=NC
CCc1sc(=NC)[nH]c1O
false
CCC1CC(C)C(CC)C1
N=c1[nH]ccs1
158.226
41.1995
0.8747
3
2
20
48.38
OCC1=CC2=C(S1)N=CO2
OCc1cc2ocnc2s1
false
CCC1CC2CCCC2C1
c1nc2sccc2o1
155.178
37.8088
1.3816
4
1
15
46.26
CCOC1=CC=C(NC)S1
CCOc1ccc(NC)s1
false
CCCC1CCC(CC)C1
c1ccsc1
157.238
45.0347
2.1885
3
1
21
21.26
CCC(=O)COS(C)(=O)=O
CCC(=O)COS(C)(=O)=O
true
CCC(C)CCC(C)(C)C
166.198
36.0938
-0.0583
4
0
20
60.44
CC(C)OS(=O)(=O)NC=N
CC(C)OS(=O)(=O)NC=N
true
CCCC(C)(C)CC(C)C
166.202
37.0602
-0.14713
4
2
20
79.25
COC1=CSC(=N1)C1CN1
COc1csc(C2CN2)n1
false
CCC1CCC(C2CC2)C1
c1csc(C2CN2)n1
156.21
39.4097
0.796
4
1
18
44.06
ON1C=CC=CCNC1=S
ON1C=CC=CCNC1=S
true
CC1CCCCCCC1C
S=C1NC=CC=CCN1
156.21
42.5062
0.6356
2
2
18
35.5
CN1NC(C#C)=C(Cl)C1=N
C#Cc1[nH]n(C)c(=N)c1Cl
false
CCC1CC(C)C(C)C1C
N=c1cc[nH][nH]1
155.588
38.5634
0.46737
2
2
16
44.57
CCCN(NC)C(=S)NO
CCCN(NC)C(=S)NO
true
CCCC(CC)C(C)CC
163.246
43.5769
0.0965
3
3
23
47.53
O=CC1C2CCS(=O)(=O)C12
O=CC1C2CCS(=O)(=O)C12
true
CCC1C2CCC(C)(C)C12
O=S1(=O)CCC2CC21
160.194
35.2358
-0.3816
3
0
18
51.21
O=C1NC2C1NCS2(=O)=O
O=C1NC2C1NCS2(=O)=O
true
CC1CC2C1CCC2(C)C
O=C1NC2C1NCS2(=O)=O
162.17
32.6412
-2.2136
4
2
16
75.27
O=S1(=O)NC2=CC=NC=C12
O=S1(=O)Nc2ccncc21
false
CC1(C)CC2CCCCC21
O=S1(=O)Nc2ccncc21
156.166
35.0455
0.1958
3
1
14
59.06
CC1(C)CNC(=S)N1C=O
CC1(C)CNC(=S)N1C=O
true
CCC1C(C)CCC1(C)C
S=C1NCCN1
158.226
42.5827
0.1115
2
1
20
32.34
CS(=O)(=O)C1=CCC(=O)N1
CS(=O)(=O)C1=CCC(=O)N1
true
CC1CCC(C(C)(C)C)C1
O=C1CC=CN1
161.182
35.6865
-0.6077
3
1
17
63.24
OC12CCOC1CS2(=O)=O
O=S1(=O)CC2OCCC21O
false
CC1(C)CC2CCCC21C
O=S1(=O)CC2OCCC21
164.182
33.0936
-1.1077
4
1
18
63.6
NN1C=CC2NC2S1(=O)=O
NN1C=CC2NC2S1(=O)=O
true
CC1CCC2CC2C1(C)C
O=S1(=O)NC=CC2NC21
161.186
34.7979
-1.6829
4
2
17
85.34
CC(=C)C1=CSN=C1CN
C=C(C)c1csnc1CN
false
CCC1CCCC1C(C)C
c1cnsc1
154.238
44.7134
1.6349
3
1
20
38.91
N=C1NCC2=C(N1)SC=C2
N=C1NCc2ccsc2N1
false
CC1CCC2CCCC2C1
N=C1NCc2ccsc2N1
153.21
42.5081
1.19797
2
3
17
47.91
N=CN1CCCCS1(=O)=O
N=CN1CCCCS1(=O)=O
true
CCC1CCCCC1(C)C
O=S1(=O)CCCCN1
162.214
38.5105
0.01907
3
1
20
61.23
NC(=S)N1CCC(=O)CC1
NC(=S)N1CCC(=O)CC1
true
CC1CCC(C(C)C)CC1
O=C1CCNCC1
158.226
42.5994
-0.1051
2
1
20
46.33
CC1CNNC(=S)NC1=C
C=C1NC(=S)NNCC1C
false
CC1CCCC(C)C(C)C1
C=C1CCNNC(=S)N1
157.242
45.1761
0.1185
2
3
21
36.09
CCCCCC1=CN=CS1
CCCCCc1cncs1
false
CCCCCC1CCCC1
c1cscn1
155.266
45.343
2.8758
2
0
23
12.89
CC1=C(Cl)C=C(O)N1C=O
Cc1c(Cl)cc(O)n1C=O
false
CCC1C(C)CC(C)C1C
c1cc[nH]c1
159.572
37.9923
1.19382
3
1
16
42.23
CNN=CC(=C)S(C)(=O)=O
C=C(C=NNC)S(C)(=O)=O
false
CCCCC(C)C(C)(C)C
162.214
41.5355
-0.2501
4
1
20
58.53
CC(NC1=NSN=C1)C#C
C#CC(C)Nc1cnsn1
false
CCC(C)CC1CCCC1
c1cnsn1
153.21
41.8267
0.9717
4
1
17
37.81
CC(C=C)S(=O)(=O)C=NO
C=CC(C)S(=O)(=O)C=NO
false
CCCC(C)(C)C(C)CC
163.198
38.8573
0.3932
4
1
19
66.73
CN(NC1CC1)S(N)(=O)=O
CN(NC1CC1)S(N)(=O)=O
true
CC(CC1CC1)C(C)(C)C
C1CC1
165.218
37.0279
-1.2113
3
2
21
75.43
CC1=NC(=NS1)C1CCC1
Cc1nc(C2CCC2)ns1
false
CC1CCC(C2CCC2)C1
c1nc(C2CCC2)ns1
154.238
41.238
2.11402
3
0
20
25.78
O=C1OCCC2=C1SC=N2
O=C1OCCc2ncsc21
false
CC1CCCC2CCCC12
O=C1OCCc2ncsc21
155.178
36.1005
0.856
4
0
15
39.19
CC1=NSC=C1C(=C)C#N
C=C(C#N)c1csnc1C
false
CCC(C)C1CCCC1C
c1cnsc1
150.206
41.498
1.9883
3
0
16
36.68
CC1NCS(=O)(=O)OC1=C
C=C1OS(=O)(=O)CNC1C
false
CC1CCC(C)(C)CC1C
C=C1CNCS(=O)(=O)O1
163.198
36.6095
-0.2043
4
1
19
55.4
CC1CN1N(C)C(=S)NO
CC1CN1N(C)C(=S)NO
true
CCC(C)C(C)C1CC1C
C1CN1
161.23
41.4512
-0.199
3
2
21
38.51
N#CC1=CSC2=C1CC=C2
N#Cc1csc2c1CC=C2
false
CCC1CCC2CCCC12
C1=Cc2sccc2C1
147.202
41.772
2.18908
2
0
15
23.79
CC(CO)C1=C(N)SN=N1
CC(CO)c1nnsc1N
false
CCC(C)C1CCCC1C
c1csnn1
159.214
39.8222
0.2161
5
2
19
72.03
OS(=O)(=O)C(=C)C=CC=O
C=C(C=CC=O)S(=O)(=O)O
false
CCCCC(C)C(C)(C)C
162.166
35.8926
0.143
3
1
16
71.44
CC(N)C1CC1NC(N)=S
CC(N)C1CC1NC(N)=S
true
CC(C)CC1CC1C(C)C
C1CC1
159.258
45.4655
-0.4447
2
3
23
64.07
CC1CC(O)C1S(O)(=O)=O
CC1CC(O)C1S(=O)(=O)O
false
CC1CC(C)C1C(C)(C)C
C1CCC1
166.198
35.1244
-0.3565
3
2
20
74.6
CC=CN(C=O)S(N)(=O)=O
CC=CN(C=O)S(N)(=O)=O
true
CCCC(CC)C(C)(C)C
164.186
35.8242
-0.8181
3
1
18
80.47
O=CC1OC2CC1S2(=O)=O
O=CC1OC2CC1S2(=O)=O
true
CCC1CC2CC1C2(C)C
O=S1(=O)C2COC1C2
162.166
32.0498
-0.9027
4
0
16
60.44
ClC1=CN=NC2=C1C=CO2
Clc1cnnc2occc12
false
CC1CCCC2CCCC12
c1cc2ccoc2nn1
154.556
36.814
1.8762
3
0
13
38.92
CN1C(C)=C(Cl)C(Cl)=C1O
Cc1c(Cl)c(Cl)c(O)n1C
false
CC1C(C)C(C)C(C)C1C
c1cc[nH]c1
180.034
41.8348
2.34592
2
1
17
25.16
CCC1CC2=NC(=O)SN12
CCC1Cc2nc(=O)sn21
false
CCC1CC2CC(C)CC12
O=c1nc2n(s1)CC2
156.21
39.406
0.812
4
0
18
34.89
CS(=O)(=O)C1NCC2NC12
CS(=O)(=O)C1NCC2NC21
false
CC(C)(C)C1CCC2CC21
C1NCC2NC12
162.214
37.3462
-1.6993
4
2
20
68.11
CC(CN)=NOS(C)(=O)=O
CC(CN)=NOS(C)(=O)=O
true
CCC(C)CCC(C)(C)C
166.202
38.0922
-0.7028
5
1
20
81.75
CC1=C2C(NC2=CS1)C=C
C=CC1Nc2csc(C)c21
false
CCC1CC2CCC(C)C12
c1scc2c1CN2
151.234
45.6167
2.70912
2
1
19
12.03
CONS(=O)(=O)C#CC#C
C#CC#CS(=O)(=O)NOC
false
CCCCC(C)(C)CCC
159.166
35.6735
-0.9387
3
1
15
55.4
O=S1(=O)CCC2OC2CO1
O=S1(=O)CCC2OC2CO1
true
CC1(C)CCC2CC2CC1
O=S1(=O)CCC2OC2CO1
164.182
33.0168
-0.4961
4
0
18
55.9
ON1C(=S)NCC=C1C=C
C=CC1=CCNC(=S)N1O
false
CCC1CCCC(C)C1C
S=C1NC=CCN1
156.21
42.5062
0.6356
2
2
18
35.5
CN1CC=CC2=C1C=NS2
CN1CC=Cc2sncc21
false
CC1CCCC2CCCC12
C1=Cc2sncc2NC1
152.222
44.418
1.6061
3
0
18
16.13
CC1NC2=C(SC=C12)C=O
CC1Nc2c1csc2C=O
false
CCC1CCC2C(C)CC12
c1scc2c1CN2
153.206
41.7442
2.0471
3
1
17
29.1
NC1=C(Cl)C(=O)N=CC=N1
Nc1nccnc(=O)c1Cl
false
CC1CCCCC(C)C1C
O=c1ccnccn1
157.56
37.7244
0.0724
4
1
14
68.87
CN(CS(=O)(=O)C=C)C=O
C=CS(=O)(=O)CN(C)C=O
false
CCC(C)CC(C)(C)CC
163.198
37.8108
-0.4096
3
0
19
54.45
CC(C)=COC1=CC=NS1
CC(C)=COc1ccns1
false
CC(C)CCC1CCCC1
c1cnsc1
155.222
42.173
2.4456
3
0
19
22.12
COC1(C)OCCS1(=O)=O
COC1(C)OCCS1(=O)=O
true
CCC1(C)CCCC1(C)C
O=S1(=O)CCOC1
166.198
35.1528
-0.2485
4
0
20
52.6
CC(OC=O)C1=CSN=C1
CC(OC=O)c1cnsc1
false
CCCC(C)C1CCCC1
c1cnsc1
157.194
37.678
1.3771
4
0
17
39.19
O=S1(=O)CC=C2OCCC12
O=S1(=O)CC=C2OCCC21
false
CC1(C)CCC2CCCC21
O=S1(=O)CC=C2OCCC21
160.194
36.2268
0.0876
3
0
18
43.37
CCC(=O)S(=O)(=O)CC=O
CCC(=O)S(=O)(=O)CC=O
true
CCCC(C)(C)C(C)CC
164.182
35.1488
-0.4633
4
0
18
68.28
CCNC(=N)C1=CN=CS1
CCNC(=N)c1cncs1
false
CCCC(C)C1CCCC1
c1cscn1
155.226
42.6194
1.07797
3
2
19
48.77
CC1N2C(CNC2=S)C1=O
CC1C(=O)C2CNC(=S)N12
false
CC1CCC2C(C)C(C)C12
O=C1CN2C(=S)NCC12
156.21
40.6967
-0.4837
2
1
18
32.34
CC1OC(C)C1NC(N)=S
CC1OC(C)C1NC(N)=S
true
CC(C)CC1C(C)CC1C
C1COC1
160.242
43.7181
-0.0046
2
2
22
47.28
CNN=CC(O)S(C)(=O)=O
CNN=CC(O)S(C)(=O)=O
true
CCCCC(C)C(C)(C)C
166.202
38.4023
-1.4454
5
2
20
78.76
NN1C(=N)SC2=C1CCC2
N=c1sc2c(n1N)CCC2
false
CC1CC2CCCC2C1C
N=c1[nH]c2c(s1)CCC2
155.226
40.3391
0.23157
4
2
19
54.8
CCC1CC2=C(C1)C=NS2
CCC1Cc2cnsc2C1
false
CCC1CC2CCCC2C1
c1nsc2c1CCC2
153.25
43.303
2.2679
2
0
21
12.89
NC1=CC2=C(CCC2=C)S1
C=C1CCc2sc(N)cc21
false
CC1CC2CCC(C)C2C1
C=C1CCc2sccc21
151.234
46.0864
2.2897
2
1
19
26.02
CC1=CC2=C(N1)C(N)=NS2
Cc1cc2snc(N)c2[nH]1
false
CC1CC2CCC(C)C2C1
c1cc2sncc2[nH]1
153.21
43.1201
1.51502
3
2
17
54.7
CC=COCC1=NSC=N1
CC=COCc1ncsn1
false
CCCCCC1CCCC1
c1ncsn1
156.21
39.512
1.5883
4
0
18
35.01
[O-][N+](=O)C1=C(C=O)C=NS1
O=Cc1cnsc1[N+](=O)[O-]
false
CCC1CCCC1C(C)C
c1cnsc1
158.138
34.1559
0.8638
5
0
12
73.1
CC1=CN=C(O1)S(C)(=O)=O
Cc1cnc(S(C)(=O)=O)o1
false
CC1CCC(C(C)(C)C)C1
c1cocn1
161.182
34.3498
0.38652
4
0
17
60.17
CC1CC1NC(=S)NC=N
CC1CC1NC(=S)NC=N
true
CCCC(C)CC1CC1C
C1CC1
157.242
45.2221
0.46597
2
3
21
47.91
ClC1=CC=NC=C1OC=O
O=COc1cnccc1Cl
false
CCCC1CCCCC1C
c1ccncc1
157.556
35.939
1.2702
3
0
14
39.19
CC1=C(C)C2=C(N1)SN=C2
Cc1[nH]c2sncc2c1C
false
CC1CC2CCCC2C1C
c1cc2cnsc2[nH]1
152.222
43.4447
2.24124
2
1
18
28.68
CN1OCC(CN)S1(=O)=O
CN1OCC(CN)S1(=O)=O
true
CCC1CCC(C)C1(C)C
O=S1(=O)CCON1
166.202
35.4772
-1.4795
4
1
20
72.63
CC1=NSC2=C1SN=C2C
Cc1nsc2c(C)nsc12
false
CC1CCC2C(C)CCC12
c1nsc2cnsc12
170.262
44.766
2.36964
4
0
16
25.78
CNCC1=CSC(N)=C1C
CNCc1csc(N)c1C
false
CCCC1CCC(C)C1C
c1ccsc1
156.254
46.2321
1.35812
3
2
22
38.05
CCC1NC2=CSC(N)=C12
CCC1Nc2csc(N)c21
false
CCC1CC2CCC(C)C12
c1scc2c1CN2
154.238
45.3861
2.2069
3
2
20
38.05
CC1(O)CC2CC2S1(=O)=O
CC1(O)CC2CC2S1(=O)=O
true
CC1(C)CC2CC2C1(C)C
O=S1(=O)CCC2CC21
162.21
36.0556
-0.0981
3
1
20
54.37
CC(C)(CNC(N)=S)C=C
C=CC(C)(C)CNC(N)=S
false
CCC(C)(C)CCC(C)C
158.27
48.7661
1.0318
1
2
24
38.05
O=CC1=NSC(=C1)C1CO1
O=Cc1cc(C2CO2)sn1
false
CCC1CCC(C2CC2)C1
c1cc(C2CO2)sn1
155.178
36.1945
1.0269
4
0
15
42.49
CN(C(C)=C)S(=O)(=O)C#N
C=C(C)N(C)S(=O)(=O)C#N
false
CCC(C)(C)C(C)C(C)C
160.198
37.1098
0.26268
3
0
18
61.17
CC=C(CCO)S(C)(=O)=O
CC=C(CCO)S(C)(=O)=O
true
CCCC(CC)C(C)(C)C
164.226
40.3036
0.3172
3
1
22
54.37
NC(CO)C1=C(O)C=CS1
NC(CO)c1sccc1O
false
CCC(C)C1CCCC1C
c1ccsc1
159.21
39.998
0.4458
4
3
19
66.48
C=CC1=CNC(S1)=NC=O
C=Cc1c[nH]c(=NC=O)s1
false
CCCC1CCC(CC)C1
N=c1[nH]ccs1
154.194
40.3877
0.7763
2
1
16
45.22
OC1CCC2=C1SC(=O)N2
O=c1[nH]c2c(s1)C(O)CC2
false
CC1CC2CCC(C)C2C1
O=c1[nH]c2c(s1)CCC2
157.194
38.2205
0.416
3
2
17
53.09
CC1(OS(=O)(=O)C=C1)C=C
C=CC1(C)C=CS(=O)(=O)O1
false
CCC1(C)CCC(C)(C)C1
O=S1(=O)C=CCO1
160.194
37.7468
0.8048
3
0
18
43.37
CC1=NSC(=O)N1CC#C
C#CCn1c(C)nsc1=O
false
CCCC1C(C)CCC1C
O=c1[nH]cns1
154.194
39.944
0.24642
4
0
16
34.89
O=CC(C#C)C1=NSC=N1
C#CC(C=O)c1ncsn1
false
CCC(CC)C1CCCC1
c1ncsn1
152.178
37.547
0.4538
4
0
14
42.85
CC1=C(OC=O)C(C)=CS1
Cc1csc(C)c1OC=O
false
CCCC1C(C)CCC1C
c1ccsc1
156.206
40.485
1.90014
3
0
18
26.3
CNCC(C=C)S(O)(=O)=O
C=CC(CNC)S(=O)(=O)O
false
CCCC(CC)C(C)(C)C
165.214
39.4603
-0.3518
3
2
21
66.4
CC(=C)CNC1=NN=CS1
C=C(C)CNc1nncs1
false
CC(C)CCC1CCCC1
c1nncs1
155.226
43.2127
1.5261
4
1
19
37.81
CC=C1CN(N)S(=O)(=O)N1
CC=C1CN(N)S(=O)(=O)N1
true
CCC1CC(C)C(C)(C)C1
C=C1CNS(=O)(=O)N1
163.202
36.7059
-1.0861
3
2
19
75.43
ONS(=O)(=O)C1CC=CC1
O=S(=O)(NO)C1CC=CC1
false
CCC(C)(C)C1CCCC1
C1=CCCC1
163.198
36.004
0.0136
3
2
19
66.4
CC=CC1CNS(=O)(=O)O1
CC=CC1CNS(=O)(=O)O1
true
CCCC1CCC(C)(C)C1
O=S1(=O)NCCO1
163.198
36.6095
-0.2043
3
1
19
55.4
CCOC1(CC1)S(N)(=O)=O
CCOC1(S(N)(=O)=O)CC1
false
CCCC1(C(C)(C)C)CC1
C1CC1
165.214
36.6982
-0.1985
3
1
21
69.39
CCC1=NCS(=O)(=O)N1C
CCC1=NCS(=O)(=O)N1C
true
CCC1CCC(C)(C)C1C
O=S1(=O)CN=CN1
162.214
39.2758
0.0276
3
0
20
49.74
OC1=CC(=CS1)C(=O)C#C
C#CC(=O)c1csc(O)c1
false
CCC(C)C1CCC(C)C1
c1ccsc1
152.174
39.1473
1.2696
3
1
14
37.3
CC1(CS(=O)(=O)C1)OC=O
CC1(OC=O)CS(=O)(=O)C1
false
CCCC1(C)CC(C)(C)C1
O=S1(=O)CCC1
164.182
34.2078
-0.6535
4
0
18
60.44