smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
CC1CON=CS(=O)(=O)C1
CC1CON=CS(=O)(=O)C1
true
CC1CCCCC(C)(C)C1
O=S1(=O)C=NOCCC1
163.198
37.3948
0.0108
4
0
19
55.73
CN1C(C)(C)CNS1(=O)=O
CN1C(C)(C)CNS1(=O)=O
true
CC1C(C)(C)CCC1(C)C
O=S1(=O)NCCN1
164.23
38.7645
-0.4552
2
1
22
49.41
CC1CC1OC1=NSN=N1
CC1CC1Oc1nnsn1
false
CC1CC1CC1CCCC1
C1CC1Oc1nnsn1
157.198
35.901
0.7203
5
0
17
47.9
S=C1NCC2CC2(N1)C#N
N#CC12CC1CNC(=S)N2
false
CCC12CC(C)CCC1C2
S=C1NCC2CC2N1
153.21
40.1874
-0.25362
2
2
17
47.85
C=C(CC1=NC=NS1)C=O
C=C(C=O)Cc1ncns1
false
CCC(C)CC1CCCC1
c1ncsn1
154.194
38.817
0.8357
4
0
16
42.85
CCS(=O)(=O)C1=CCC=C1
CCS(=O)(=O)C1=CCC=C1
true
CCC(C)(C)C1CCCC1
C1=CCC=C1
158.222
41.3008
1.2649
2
0
20
34.14
CC1=C(C)C(Cl)=C(O1)C#C
C#Cc1oc(C)c(C)c1Cl
false
CCC1CC(C)C(C)C1C
c1ccoc1
154.596
41.127
2.53114
1
0
17
13.14
O=S(=O)(CC#C)OC1CC1
C#CCS(=O)(=O)OC1CC1
false
CCCC(C)(C)CC1CC1
C1CC1
160.194
36.7268
0.1284
3
0
18
43.37
CC1=CCN(O)S(=O)(=O)N1
CC1=CCN(O)S(=O)(=O)N1
true
CC1CCC(C)C(C)(C)C1
O=S1(=O)NC=CCN1
164.186
34.305
-0.5706
3
2
18
69.64
OS(=O)(=O)C#CC#CC=O
O=CC#CC#CS(=O)(=O)O
false
CCCCCCC(C)(C)C
158.134
33.1646
-0.9626
3
1
12
71.44
CCN1N(C)SC(=O)C1=N
CCn1c(=N)c(=O)sn1C
false
CCC1C(C)CC(C)C1C
N=c1[nH][nH]sc1=O
159.214
39.0787
-0.25233
5
1
19
50.78
C=CCCN1SC=CC1=O
C=CCCn1sccc1=O
false
CCCCC1CCCC1C
O=c1ccs[nH]1
155.222
43.393
1.4859
3
0
19
22
CN(C(=C)C#N)S(C)(=O)=O
C=C(C#N)N(C)S(C)(=O)=O
false
CCC(C)C(C)C(C)(C)C
160.198
37.3598
-0.08492
3
0
18
61.17
CNC1=CSC(C#C)=C1O
C#Cc1scc(NC)c1O
false
CCC1CCC(CC)C1C
c1ccsc1
153.206
43.4655
1.4767
3
2
17
32.26
CC(=C)C1=C(SN=C1)C#N
C=C(C)c1cnsc1C#N
false
CCC1CCCC1C(C)C
c1cnsc1
150.206
41.537
2.04788
3
0
16
36.68
CS(=O)(=O)C1=CNC(O)=C1
CS(=O)(=O)c1c[nH]c(O)c1
false
CC1CCC(C(C)(C)C)C1
c1cc[nH]c1
161.182
35.5673
0.1238
3
2
17
70.16
N=C1SC=C2C=NC(=O)N12
N=c1scc2n1C(=O)N=C2
false
CC1CCC2CCC(C)C12
N=c1scc2n1C(=O)N=C2
153.166
36.5517
0.42967
4
1
13
58.21
CN1C(C=O)C2=NSC=C12
CN1c2csnc2C1C=O
false
CCC1C(C)C2CCCC12
c1snc2c1NC2
154.194
39.322
0.8329
4
0
16
33.2
COC1=C2CN(C)C2=NS1
COc1snc2c1CN2C
false
CCC1CCC2C(C)CC12
c1snc2c1CN2
156.21
40.773
1.1015
4
0
18
25.36
CC1=COC2=C(C1)N=CS2
CC1=COc2scnc2C1
false
CC1CCC2CCCC2C1
C1=COc2scnc2C1
153.206
40.203
1.9818
3
0
17
22.12
NC1=C2N=NC=CC2=CS1
Nc1scc2ccnnc12
false
CC1CCC2CCCCC12
c1cc2cscc2nn1
151.194
41.8274
1.2735
4
1
15
51.8
CC(C#N)C(=C)NC(N)=S
C=C(NC(N)=S)C(C)C#N
false
CCC(C)C(C)CC(C)C
155.226
43.8381
0.49298
2
2
19
61.84
ON(C=N)C(=S)NCC#C
C#CCNC(=S)N(O)C=N
false
CCCCC(C)C(C)CC
157.198
41.8429
-0.20763
3
3
17
59.35
CC1=C(O)CC2=C1SC=C2
CC1=C(O)Cc2ccsc21
false
CC1CC2CCCC2C1C
C1=Cc2sccc2C1
152.218
43.2458
2.5932
2
1
18
20.23
CC(=N)NS(=O)(=O)NC=C
C=CNS(=O)(=O)NC(C)=N
false
CCCC(C)(C)CC(C)C
163.202
38.7889
-0.44893
3
3
19
82.05
NC1=C(SC=C1)C(O)=CO
Nc1ccsc1C(O)=CO
false
CCC(C)C1CCCC1C
c1ccsc1
157.194
41.966
1.7447
4
3
17
66.48
NN1SC=C2C=CCN=C12
NN1SC=C2C=CCN=C21
false
CC1CCC2CCCCC12
C1=CC2=CSNC2=NC1
153.21
43.1424
0.6761
4
1
17
41.62
OC1CNNC(=S)NC=C1
OC1C=CNC(=S)NNC1
false
CC1CCCC(C)CCC1
S=C1NC=CCCNN1
159.214
42.0189
-1.1567
3
4
19
56.32
O=S1(=O)CC=C2CCNN12
O=S1(=O)CC=C2CCNN21
false
CC1(C)CCC2CCCC21
O=S1(=O)CC=C2CCNN21
160.198
36.3285
-0.576
3
1
18
49.41
NC1=C(CCC=C)SC=N1
C=CCCc1scnc1N
false
CCCCC1CCCC1C
c1cscn1
154.238
45.0444
1.8439
3
1
20
38.91
CC(C)S(=O)(=O)C(=O)C=C
C=CC(=O)S(=O)(=O)C(C)C
false
CCC(C)C(C)(C)C(C)C
162.21
39.2598
0.5222
3
0
20
51.21
CN(OCC=C)S(N)(=O)=O
C=CCON(C)S(N)(=O)=O
false
CCCCC(C)C(C)(C)C
166.202
37.0192
-0.7607
3
1
20
72.63
CC1=C(SC=N1)C=CC=C
C=CC=Cc1scnc1C
false
CCCCC1CCCC1C
c1cscn1
151.234
46.082
2.65072
2
0
19
12.89
O=C1N=CNC(=S)N2CC12
O=C1N=CNC(=S)N2CC12
true
CC1CCCC(C)C2CC12
O=C1N=CNC(=S)N2CC12
155.182
39.7267
-0.8864
2
1
15
44.47
CNC1=NN=C(CC#C)S1
C#CCc1nnc(NC)s1
false
CCCC1CCC(CC)C1
c1nncs1
153.21
41.9927
0.7555
4
1
17
37.81
O=S1(=O)C=CC2=C1N=NN2
O=S1(=O)C=Cc2[nH]nnc21
false
CC1(C)CCC2CCCC21
O=S1(=O)C=Cc2[nH]nnc21
157.154
32.6025
-0.4373
4
1
13
75.71
CCC=C(CN)S(N)(=O)=O
CCC=C(CN)S(N)(=O)=O
true
CCCC(CC)C(C)(C)C
164.23
40.5356
-0.4725
3
2
22
86.18
ClC1=CC=CC2=C1ON=N2
Clc1cccc2nnoc12
false
CC1CCCC2CCCC12
c1ccc2onnc2c1
154.556
36.814
1.8762
3
0
13
38.92
NCC1=NSC(C#C)=C1N
C#Cc1snc(CN)c1N
false
CCC1CCC(CC)C1C
c1cnsc1
153.21
42.3528
0.1653
4
2
17
64.93
CNCCC1=NSC(=O)N1
CNCCc1nsc(=O)[nH]1
false
CCCCC1CCC(C)C1
O=c1[nH]cns1
159.214
40.3654
-0.4067
4
2
19
57.78
CCOS(=O)(=O)N1CC1C
CCOS(=O)(=O)N1CC1C
true
CCCC(C)(C)C1CC1C
C1CN1
165.214
36.7138
-0.0282
3
0
21
46.38
C=C1C2OC2C2=C1SN=N2
C=C1c2snnc2C2OC12
false
CC1C2CCCC2C2CC12
C=C1c2snnc2C2OC12
152.178
36.557
1.0048
4
0
14
38.31
CCC1=C(C#N)C(O)=CS1
CCc1scc(O)c1C#N
false
CCC1CCC(C)C1CC
c1ccsc1
153.206
40.0768
1.88778
3
1
17
44.02
CC1=CN(C(N)=S)C(=N)C1
CC1=CN(C(N)=S)C(=N)C1
true
CC1CC(C)C(C(C)C)C1
N=C1CC=CN1
155.226
44.7251
0.81677
2
2
19
53.11
C#CC1=CC2=CSC=C2O1
C#Cc1cc2cscc2o1
false
CCC1CC2CCCC2C1
c1cc2cscc2o1
148.186
42.026
2.4756
2
0
14
13.14
CCC1=C(N)N=C(S1)C=O
CCc1sc(C=O)nc1N
false
CCC1CC(C)C(CC)C1
c1cscn1
156.21
41.2919
1.1002
4
1
18
55.98
NC1=C(CC#C)OC=C1Cl
C#CCc1occ(Cl)c1N
false
CCCC1CCC(C)C1C
c1ccoc1
155.584
40.6674
1.6909
2
1
16
39.16
NC1=CSC(=C1)C(=O)CO
Nc1csc(C(=O)CO)c1
false
CCC(C)C1CCC(C)C1
c1ccsc1
157.194
40.1477
0.5053
4
2
17
63.32
CS(=O)(=O)C1(CO)CCC1
CS(=O)(=O)C1(CO)CCC1
true
CCC1(C(C)(C)C)CCC1
C1CCC1
164.226
38.5116
-0.054
3
1
22
54.37
CC1=C(CNC=O)N=NS1
Cc1snnc1CNC=O
false
CCCCC1CCCC1C
c1csnn1
157.198
37.5497
0.09252
4
1
17
54.88
NCC1=CS(=O)(=O)NC1=C
C=C1NS(=O)(=O)C=C1CN
false
CCC1CC(C)(C)CC1C
C=C1C=CS(=O)(=O)N1
160.198
38.3329
-0.7243
3
2
18
72.19
NCC=COC1=CSN=C1
NCC=COc1cnsc1
false
CCCCCC1CCCC1
c1cnsc1
156.21
40.9364
0.9943
4
1
18
48.14
OS(=O)(=O)C1COCC=C1
O=S(=O)(O)C1C=CCOC1
false
CC(C)(C)C1CCCCC1
C1=CCOCC1
164.182
35.2956
-0.1708
3
1
18
63.6
CC1=NC=CC2=C1C=NS2
Cc1nccc2sncc12
false
CC1CCCC2CCCC12
c1cc2sncc2cn1
150.206
42.152
1.99972
3
0
16
25.78
ClC1=CN=C2C=NOC2=C1
Clc1cnc2cnoc2c1
false
CC1CCC2CCCC2C1
c1cnc2cnoc2c1
154.556
36.814
1.8762
3
0
13
38.92
CCCCC1=NSC=C1O
CCCCc1nscc1O
false
CCCCC1CCCC1C
c1cnsc1
157.238
42.3908
2.1913
3
1
21
33.12
CCC1=C(SN=N1)C(C)=C
C=C(C)c1snnc1CC
false
CCC1CCCC1C(C)C
c1csnn1
154.238
43.995
2.1336
3
0
20
25.78
N=C1SNC2=C1NC2C=O
N=c1s[nH]c2c1NC2C=O
false
CCC1CC2C(C)CCC12
N=c1s[nH]c2c1NC2
155.182
36.9521
0.22117
4
3
15
68.74
CN(CC=C)S(=O)(=O)C=O
C=CCN(C)S(=O)(=O)C=O
false
CCCC(C)C(C)(C)CC
163.198
38.4973
-0.3758
3
0
19
54.45
CCC1CC1S(=O)(=O)C=O
CCC1CC1S(=O)(=O)C=O
true
CCC1CC1C(C)(C)CC
C1CC1
162.21
37.8563
0.3899
3
0
20
51.21
CC1CC(N1)C1=NC=NS1
CC1CC(c2ncns2)N1
false
CC1CC(C2CCCC2)C1
c1nsc(C2CCN2)n1
155.226
39.8647
0.961
4
1
19
37.81
CN1C=CN=CNS1(=O)=O
CN1C=CN=CNS1(=O)=O
true
CC1CCCCCC1(C)C
O=S1(=O)NC=CN=CN1
161.186
37.4505
-0.7343
3
1
17
61.77
NC1=C(SN=C1)C#CC=C
C=CC#Cc1sncc1N
false
CCCCC1CCCC1C
c1cnsc1
150.206
43.6014
1.2628
3
1
16
38.91
NC1=C(O)C(Cl)=C(O1)C#C
C#Cc1oc(N)c(O)c1Cl
false
CCC1CC(C)C(C)C1C
c1ccoc1
157.556
37.7302
1.2021
3
2
14
59.39
CC(C)(N)C1=NC(=O)SN1
CC(C)(N)c1nc(=O)s[nH]1
false
CC1CCC(C(C)(C)C)C1
O=c1nc[nH]s1
159.214
39.9481
0.0252
4
2
19
71.77
CON1CC(C)CS1(=O)=O
CON1CC(C)CS1(=O)=O
true
CCC1CC(C)CC1(C)C
O=S1(=O)CCCN1
165.214
36.6658
-0.1707
3
0
21
46.61
CNS(=O)(=O)NC(C)C=C
C=CC(C)NS(=O)(=O)NC
false
CCC(C)CC(C)(C)CC
164.23
40.7742
-0.3853
2
2
22
58.2
CCC(=C)OS(=O)(=O)CC
C=C(CC)OS(=O)(=O)CC
false
CCC(C)CC(C)(C)CC
164.226
39.9768
1.2764
3
0
22
43.37
COC=CCC1=NC=NS1
COC=CCc1ncns1
false
CCCCCC1CCCC1
c1ncsn1
156.21
39.762
1.2407
4
0
18
35.01
C=CC12CCS(=O)(=O)C1N2
C=CC12CCS(=O)(=O)C1N2
true
CCC12CCC(C)(C)C1C2
O=S1(=O)CCC2NC21
159.21
38.2555
-0.341
3
1
19
56.08
CC1NC(=S)NCC1C#C
C#CC1CNC(=S)NC1C
false
CCC1CCC(C)CC1C
S=C1NCCCN1
154.238
45.5214
0.102
1
2
20
24.06
CC1NNS(=O)(=O)NC1C
CC1NNS(=O)(=O)NC1C
true
CC1CCC(C)(C)CC1C
O=S1(=O)NCCNN1
165.218
37.2509
-1.2944
3
3
21
70.23
CC=CC1=NSN=C1NO
CC=Cc1nsnc1NO
false
CCCC1CCCC1CC
c1cnsn1
157.198
40.0262
1.3723
5
2
17
58.04
NCC(C#C)C1=CSC=N1
C#CC(CN)c1cscn1
false
CCC(CC)C1CCCC1
c1cscn1
152.222
42.7424
0.8186
3
1
18
38.91
CCN=CN1C=CSC1=N
CCN=Cn1ccsc1=N
false
CCCCC1CCCC1C
N=c1[nH]ccs1
155.226
42.5947
0.92537
4
1
19
41.14
CN=C1C=NS(=O)(=O)N1C
CN=C1C=NS(=O)(=O)N1C
true
CCC1CCC(C)(C)C1C
N=C1C=NS(=O)(=O)N1
161.186
38.5338
-0.7243
3
0
17
62.1
C=C1CNS(=O)(=O)C(=O)N1
C=C1CNS(=O)(=O)C(=O)N1
true
CC1CCC(C)(C)C(C)C1
C=C1CNS(=O)(=O)C(=O)N1
162.17
34.5942
-0.8573
3
2
16
75.27
CC12CC(N1)S(=O)(=O)C2=C
C=C1C2(C)CC(N2)S1(=O)=O
false
CC1C2(C)CC(C2)C1(C)C
C=C1C2CC(N2)S1(=O)=O
159.21
38.0055
0.0066
3
1
19
46.17
CCCCC1=CC(=O)SN1
CCCCc1cc(=O)s[nH]1
false
CCCCC1CCC(C)C1
O=c1cc[nH]s1
157.238
43.5517
1.779
2
1
21
32.86
CS(=O)(=O)C1C2CCOC12
CS(=O)(=O)C1C2CCOC21
false
CC(C)(C)C1C2CCCC21
C1CC2CC2O1
162.21
36.4788
-0.1817
3
0
20
43.37
CNC1=C(C)SC(O)=C1O
CNc1c(C)sc(O)c1O
false
CCC1C(C)CC(C)C1C
c1ccsc1
159.21
41.9323
1.50942
4
3
19
52.49
CC1=CC(=CS1)C(=N)NO
Cc1cc(C(=N)NO)cs1
false
CCC(C)C1CCC(C)C1
c1ccsc1
156.21
40.8069
1.36069
3
3
18
56.11
COC(C)C1CS(=O)(=O)C1
COC(C)C1CS(=O)(=O)C1
true
CCC(C)C1CC(C)(C)C1
O=S1(=O)CCC1
164.226
38.6148
0.0659
3
0
22
43.37
OC1=CSC2=NCC=NN12
OC1=CSC2=NCC=NN12
true
CC1CCC2CCCCC12
C1=CN2N=CCN=C2S1
155.182
40.9358
0.7475
5
1
15
48.19
CC(=C)CNC(=S)NC=C
C=CNC(=S)NCC(=C)C
false
CCCC(C)CCC(C)C
156.254
48.7474
1.1701
1
2
22
24.06
CN(CC(C)=C)S(N)(=O)=O
C=C(C)CN(C)S(N)(=O)=O
false
CC(C)CC(C)C(C)(C)C
164.23
40.5512
-0.3022
2
1
22
63.4
CC(C)NS(=O)(=O)C(C)N
CC(C)NS(=O)(=O)C(C)N
true
CC(C)CC(C)(C)C(C)C
166.246
40.8409
-0.3811
3
2
24
72.19
CCC(=C)C1CS(=O)(=O)N1
C=C(CC)C1CS(=O)(=O)N1
false
CCC(C)C1CC(C)(C)C1
O=S1(=O)CCN1
161.226
40.1415
0.2542
2
1
21
46.17
C1OC2C1OC1=NSC=C21
c1snc2c1C1OCC1O2
false
C1CC2CC3CCC3C2C1
c1snc2c1C1OCC1O2
155.178
35.223
0.9754
4
0
15
31.35
CCC1CCN1NC(N)=S
CCC1CCN1NC(N)=S
true
CCC1CCC1CC(C)C
C1CNC1
159.258
45.3231
0.2189
2
2
23
41.29
CC(N)C1(N)CNS1(=O)=O
CC(N)C1(N)CNS1(=O)=O
true
CC(C)C1(C)CCC1(C)C
O=S1(=O)CCN1
165.218
37.4903
-2.0784
4
3
21
98.21
CC1CC2=C(SN=C12)C#C
C#Cc1snc2c1CC2C
false
CCC1CCC2C(C)CC12
c1snc2c1CC2
149.218
42.168
1.784
2
0
17
12.89
C(C1CCO1)C1=CSC=N1
c1nc(CC2CCO2)cs1
false
C1CCC(CC2CCC2)C1
c1nc(CC2CCO2)cs1
155.222
40.175
1.4745
3
0
19
22.12
CC1C(C1(C)C)S(C)(=O)=O
CC1C(S(C)(=O)=O)C1(C)C
false
CC1C(C(C)(C)C)C1(C)C
C1CC1
162.254
41.5768
1.0755
2
0
24
34.14
C1CC11C=CC2=CSC=C12
C1=CC2(CC2)c2cscc21
false
C1CC2CCC3(CC3)C2C1
C1=CC2(CC2)c2cscc21
148.23
44.265
2.8065
1
0
18
0
CC1NC(=O)C2=NSC=C12
CC1NC(=O)c2nscc21
false
CC1CC(C)C2CCCC12
O=C1NCc2csnc21
154.194
37.9952
0.9475
3
1
16
41.99
CN(C)CC1=CSC=C1Cl
CN(C)Cc1cscc1Cl
false
CC(C)CC1CCCC1C
c1ccsc1
175.684
46.72
2.4631
2
0
20
3.24
CC12CC(O1)C(=C)S2(=O)=O
C=C1C2CC(C)(O2)S1(=O)=O
false
CC1C2CC(C)(C2)C1(C)C
C=C1C2CC(O2)S1(=O)=O
160.194
35.9548
0.4336
3
0
18
43.37
COC1=CN2C=NSC2=C1
COc1cc2sncn2c1
false
CCC1CC2CCCC2C1
c1cc2sncn2c1
154.194
39.621
1.4044
4
0
16
26.53
NC1=CC=C(Cl)C(C=C)=N1
C=Cc1nc(N)ccc1Cl
false
CCC1CC(C)CCC1C
c1ccncc1
154.6
43.7504
1.9602
2
1
17
38.91