smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
CN=C1SN(C=C)C(C)=N1
C=Cn1sc(=NC)nc1C
false
CCC1CC(C)C(CC)C1
N=c1nc[nH]s1
155.226
42.715
0.88402
4
0
19
30.18
CNS(=O)(=O)OC1(C)CC1
CNS(=O)(=O)OC1(C)CC1
true
CCC(C)(C)CC1(C)CC1
C1CC1
165.214
36.7035
0.0197
3
1
21
55.4
CN=CN(O)C1=NSC=C1
CN=CN(O)c1ccsn1
false
CCCC(C)C1CCCC1
c1cnsc1
157.198
40.7955
0.9968
4
1
17
48.72
NCC1=C(C=CS1)C(N)=O
NCc1sccc1C(N)=O
false
CCC1CCCC1C(C)C
c1ccsc1
156.21
40.7283
0.3057
3
2
18
69.11
CCNC1=CC(Cl)=C(N)S1
CCNc1cc(Cl)c(N)s1
false
CCCC1CC(C)C(C)C1
c1ccsc1
176.672
47.9051
2.4155
3
2
19
38.05
CC(C)(N1CC1)S(N)(=O)=O
CC(C)(N1CC1)S(N)(=O)=O
true
CC(C)(C)C(C)(C)C1CC1
C1CN1
164.23
38.7592
-0.6734
3
1
22
63.17
COC1=NC(=N)C(Cl)=CN1
COc1nc(=N)c(Cl)c[nH]1
false
CCC1CCC(C)C(C)C1
N=c1cc[nH]cn1
159.576
36.0044
0.55117
3
2
16
61.76
C#CC1=C(SC=N1)N1CC1
C#Cc1ncsc1N1CC1
false
CCC1CCCC1C1CC1
c1ncc(N2CC2)s1
150.206
42.262
0.9444
3
0
16
15.9
CNC(NC(N)=S)=CC#N
CNC(=CC#N)NC(N)=S
false
CCCC(CC)CC(C)C
156.214
42.6768
-0.59602
3
3
18
73.87
CC1=C(C=NS1)C#CC=C
C=CC#Cc1cnsc1C
false
CCCCC1CCCC1C
c1cnsc1
149.218
43.926
1.98902
2
0
17
12.89
C=CNS(=O)(=O)CCC=O
C=CNS(=O)(=O)CCC=O
true
CCCCC(C)(C)CCC
163.198
37.8005
-0.3617
3
1
19
63.24
CC(C#C)C1=NC(=N)SN1
C#CC(C)c1nc(=N)s[nH]1
false
CCC(C)C1CCC(C)C1
N=c1nc[nH]s1
153.21
39.5674
0.68737
3
2
17
52.53
OCC1=C(CC=O)SN=C1
O=CCc1sncc1CO
false
CCCC1CCCC1CC
c1cnsc1
157.194
37.8048
0.3768
4
1
17
50.19
CS(=O)(=O)CC1CCNC1
CS(=O)(=O)CC1CCNC1
true
CC(C)(C)CC1CCCC1
C1CCNC1
163.242
40.6875
-0.3595
3
1
23
46.17
CCC1(C)NS(=O)(=O)C=C1
CCC1(C)C=CS(=O)(=O)N1
false
CCC1(C)CCC(C)(C)C1
O=S1(=O)C=CCN1
161.226
39.8915
0.6018
2
1
21
46.17
NC1=CSC(C=NN=C)=C1
C=NN=Cc1cc(N)cs1
false
CCCCC1CCC(C)C1
c1ccsc1
153.21
45.8744
1.3648
4
1
17
50.74
CCNC1=CC(OC)=NS1
CCNc1cc(OC)ns1
false
CCCC1CCC(CC)C1
c1cnsc1
158.226
42.8297
1.5835
4
1
20
34.15
CC1NC1(C#C)S(N)(=O)=O
C#CC1(S(N)(=O)=O)NC1C
false
CCC1(C(C)(C)C)CC1C
C1CN1
160.198
37.2689
-1.4039
3
2
18
82.1
ON1C=C(Cl)C(CC#C)=N1
C#CCc1nn(O)cc1Cl
false
CCCC1CC(C)CC1C
c1cn[nH]c1
156.572
36.9585
0.9495
3
1
15
38.05
NC(=N)C(=C)C1=CC=NS1
C=C(C(=N)N)c1ccns1
false
CC(C)C(C)C1CCCC1
c1cnsc1
153.21
43.0621
1.09227
3
2
17
62.76
S1C=C2C(=C1)C1=NSN=C21
c1scc2c1-c1nsnc1-2
false
C1CC2C(C1)C1CCCC21
c1scc2c1-c1nsnc1-2
166.23
42.216
2.247
4
0
12
25.78
N#CCN1CC2=NSN=C12
N#CCN1Cc2nsnc21
false
CCCC1CC2CCCC12
C1Nc2nsnc21
152.182
36.572
0.38168
5
0
14
52.81
CC1=CC=C(N)C(Cl)=C1C
Cc1ccc(N)c(Cl)c1C
false
CC1CCC(C)C(C)C1C
c1ccccc1
155.628
45.3384
2.53904
1
1
20
26.02
CNS(=O)(=O)CC1NC1C
CNS(=O)(=O)CC1NC1C
true
CCC(C)(C)CC1CC1C
C1CN1
164.23
39.2322
-1.1041
3
2
22
68.11
COC(C(C)C)S(O)(=O)=O
COC(C(C)C)S(=O)(=O)O
false
CCC(C(C)C)C(C)(C)C
168.214
37.1836
0.5027
3
1
22
63.6
CNC1=NC(=CS1)C(C)=O
CNc1nc(C(C)=O)cs1
false
CCC1CCC(C(C)C)C1
c1cscn1
156.21
41.6652
1.3874
4
1
18
41.99
CON1C=C(N)C(Cl)=C1N
COn1cc(N)c(Cl)c1N
false
CCC1CC(C)C(C)C1C
c1cc[nH]c1
161.592
40.7708
0.3643
4
2
18
66.2
N=C1NN=C(S1)C#CC=O
N=c1[nH]nc(C#CC=O)s1
false
CCCCC1CCC(C)C1
N=c1[nH]ncs1
153.166
35.2614
-0.49893
4
2
13
69.6
COCS(=O)(=O)C(C)(C)O
COCS(=O)(=O)C(C)(C)O
true
CCCC(C)(C)C(C)(C)C
168.214
37.0936
-0.2665
4
1
22
63.6
CC(=C)C1=C(C)OC=C1Cl
C=C(C)c1c(Cl)coc1C
false
CC(C)C1C(C)CCC1C
c1ccoc1
156.612
43.163
3.27452
1
0
19
13.14
CC(ON=C)C1=CSC=N1
C=NOC(C)c1cscn1
false
CCCC(C)C1CCCC1
c1cscn1
156.21
41.163
1.8363
4
0
18
34.48
CCC12CC(N1)S(=O)(=O)C2
CCC12CC(N1)S(=O)(=O)C2
true
CCC12CC(C1)C(C)(C)C2
O=S1(=O)CC2CC1N2
161.226
38.3495
-0.117
3
1
21
46.17
CCC1=NN=C(CC=O)S1
CCc1nnc(CC=O)s1
false
CCCC1CCC(CC)C1
c1nncs1
156.21
39.055
0.8419
4
0
18
42.85
NC(=S)N1CC11COC=C1
NC(=S)N1CC12C=COC2
false
CC(C)C1CC12CCCC2
C1=CC2(CN2)CO1
156.21
41.3144
-0.1717
2
1
18
38.26
O=CNC=NC1=CSC=N1
O=CNC=Nc1cscn1
false
CCCCCC1CCCC1
c1cscn1
155.182
39.4657
0.5489
4
1
15
54.35
CC1C(=CNS1(=O)=O)C#C
C#CC1=CNS(=O)(=O)C1C
false
CCC1CCC(C)(C)C1C
O=S1(=O)CC=CN1
157.194
38.4335
-0.175
2
1
17
46.17
ON1CC2=C(C=CS2)C1=N
N=C1c2ccsc2CN1O
false
CC1CC2CCCC2C1C
N=C1NCc2sccc21
154.194
38.4772
1.27827
3
2
16
47.32
CC1CC2=C(O1)C(C)=NS2
Cc1nsc2c1OC(C)C2
false
CC1CC2CCC(C)C2C1
c1nsc2c1OCC2
155.222
40.645
1.77492
3
0
19
22.12
NCCCC1=NC(=O)SN1
NCCCc1nc(=O)s[nH]1
false
CCCCC1CCC(C)C1
O=c1nc[nH]s1
159.214
40.1101
-0.2773
4
2
19
71.77
CCC(C)C1=NNC(=O)S1
CCC(C)c1n[nH]c(=O)s1
false
CCC(C)C1CCC(C)C1
O=c1[nH]ncs1
158.226
41.4407
1.3449
3
1
20
45.75
CONC1=NSN=C1C=C
C=Cc1nsnc1NOC
false
CCCC1CCCC1CC
c1cnsn1
157.198
40.6317
1.1544
5
1
17
47.04
CCC1OC2=NSC(O)=C12
CCC1Oc2nsc(O)c21
false
CCC1CC2CCC(C)C12
c1snc2c1CO2
157.194
37.4388
1.6922
4
1
17
42.35
CC(N(C)C(N)=S)C(C)=C
C=C(C)C(C)N(C)C(N)=S
false
CC(C)C(C)C(C)C(C)C
158.27
48.8244
1.1264
1
1
24
29.26
O=C1NS(=O)(=O)CN2CC12
O=C1NS(=O)(=O)CN2CC12
true
CC1CC(C)(C)CC2CC12
O=C1NS(=O)(=O)CN2CC12
162.17
32.4235
-1.9123
4
1
16
66.25
CON1SC(=CC1=N)C#C
C#Cc1cc(=N)n(OC)s1
false
CCC1CC(C)C(CC)C1
N=c1ccs[nH]1
154.194
38.6027
0.06877
4
1
16
38.01
CC#CC(C)(C)S(O)(=O)=O
CC#CC(C)(C)S(=O)(=O)O
false
CCCC(C)(C)C(C)(C)C
162.21
39.0776
0.6761
2
1
20
54.37
COC(=C)C1CNC(=S)N1
C=C(OC)C1CNC(=S)N1
false
CCC(C)C1CCC(C)C1
S=C1NCCN1
158.226
43.6734
-0.0072
2
2
20
33.29
O=S1(=O)CNCCC1C#N
N#CC1CCNCS1(=O)=O
false
CCC1CCCCC1(C)C
O=S1(=O)CCCNC1
160.198
35.8075
-0.75582
4
1
18
69.96
CNCC1=C2NCC2=NS1
CNCc1snc2c1NC2
false
CCCC1CCC2CCC12
c1snc2c1NC2
155.226
42.2044
0.788
4
2
19
36.95
NC1=CS(=O)(=O)C=NOC1
NC1=CS(=O)(=O)C=NOC1
true
CC1CCCCC(C)(C)C1
O=S1(=O)C=CCON=C1
162.17
35.6342
-0.8252
5
1
16
81.75
CCON1CC2CN2C1=S
CCON1CC2CN2C1=S
true
CCCC1CC2CC2C1C
S=C1NCC2CN12
158.226
41.424
0.2226
2
0
20
15.48
NN1CC2(COC2)NC1=S
NN1CC2(COC2)NC1=S
true
CC1CC2(CCC2)CC1C
S=C1NCC2(COC2)N1
159.214
40.1771
-1.1808
3
2
19
50.52
CC1=NN=C(S1)C=CCN
Cc1nnc(C=CCN)s1
false
CCCCC1CCC(C)C1
c1nncs1
155.226
42.7344
0.81842
4
1
19
51.8
CCNC1=C(C=C)C=CS1
C=Cc1ccsc1NCC
false
CCCC1CCCC1CC
c1ccsc1
153.25
48.5737
2.8229
2
1
21
12.03
C=C1CC(=O)OCS1(=O)=O
C=C1CC(=O)OCS1(=O)=O
true
CC1CCC(C)(C)C(C)C1
C=C1CC(=O)OCS1(=O)=O
162.166
33.6358
-0.1807
4
0
16
60.44
CC(C)C1=NSC(O)=C1C
Cc1c(C(C)C)nsc1O
false
CC(C)C1CCC(C)C1C
c1cnsc1
157.238
42.6048
2.28052
3
1
21
33.12
OS(=O)(=O)CN1C=CN=C1
O=S(=O)(O)Cn1ccnc1
false
CC(C)(C)CC1CCCC1
c1c[nH]cn1
162.17
33.7756
-0.2716
4
1
16
72.19
OC1=CSC=C1CCC=O
O=CCCc1cscc1O
false
CCCCC1CCCC1C
c1ccsc1
156.206
40.3688
1.5852
3
1
18
37.3
CC1N(C)C(=S)NC=C1C
CC1=CNC(=S)N(C)C1C
false
CC1CCC(C)C(C)C1C
S=C1NC=CCN1
156.254
46.7157
1.0986
1
1
22
15.27
O=C1CCN1C1=NC=NS1
O=C1CCN1c1ncns1
false
CC1CCC1C1CCCC1
O=C1CCN1c1ncns1
155.182
36.879
0.2748
4
0
15
46.09
NC1=C(N)C=C(CC#N)S1
N#CCc1cc(N)c(N)s1
false
CCCC1CC(C)C(C)C1
c1ccsc1
153.21
42.4608
0.97858
4
2
17
75.83
C=CC1=NC2=C(O1)C=NS2
C=Cc1nc2sncc2o1
false
CCC1CC2CCCC2C1
c1nc2sncc2o1
152.178
39.772
1.9273
4
0
14
38.92
CCC(=NO)S(=O)(=O)NC
CCC(=NO)S(=O)(=O)NC
true
CCC(CC)C(C)(C)CC
166.202
37.492
-0.2667
4
2
20
78.76
C#CC1=CC2=C(OC=N2)S1
C#Cc1cc2ncoc2s1
false
CCC1CC2CCCC2C1
c1nc2ccsc2o1
149.174
39.821
1.8706
3
0
13
26.03
CC1(NC1S(O)(=O)=O)C#C
C#CC1(C)NC1S(=O)(=O)O
false
CCC1(C)CC1C(C)(C)C
C1CN1
161.182
35.7103
-0.8046
3
2
17
76.31
CC(C=O)C1=C(C)N=CS1
Cc1ncsc1C(C)C=O
false
CCC(C)C1CCCC1C
c1cscn1
155.222
41.33
1.75392
3
0
19
29.96
CC(N1CC1)C1=CSN=N1
CC(c1csnn1)N1CC1
false
CC(C1CCCC1)C1CC1
c1snnc1CN1CC1
155.226
39.897
0.9147
4
0
19
28.79
CC1=NC2=C(S1)C1CC1C2
Cc1nc2c(s1)C1CC1C2
false
CC1CC2CC3CC3C2C1
c1nc2c(s1)C1CC1C2
151.234
41.403
2.11112
2
0
19
12.89
OC1C2CC1C1=NSN=C21
OC1C2CC1c1nsnc12
false
CC1C2CC1C1CCCC21
C1C2CC1c1nsnc12
154.194
36.0148
0.4835
4
1
16
46.01
C=C1C=NNC(=O)S1(=O)=O
C=C1C=NNC(=O)S1(=O)=O
true
CC1CCCC(C)C1(C)C
C=C1C=NNC(=O)S1(=O)=O
160.154
35.0835
-0.3761
4
1
14
75.6
CC(C)C1(C)CS(=O)(=O)O1
CC(C)C1(C)CS(=O)(=O)O1
true
CC(C)C1(C)CC(C)(C)C1
O=S1(=O)CCO1
164.226
38.1148
0.7611
3
0
22
43.37
OC1C=CN(C=C)S1(=O)=O
C=CN1C=CC(O)S1(=O)=O
false
CCC1CCC(C)C1(C)C
O=S1(=O)CC=CN1
161.182
36.1026
-0.3926
3
1
17
57.61
CC(C)=CS(=O)(=O)CCO
CC(C)=CS(=O)(=O)CCO
true
CCCC(C)(C)CC(C)C
164.226
40.3036
0.3172
3
1
22
54.37
O=CCOC1CCS1(=O)=O
O=CCOC1CCS1(=O)=O
true
CCCCC1CCC1(C)C
O=S1(=O)CCC1
164.182
34.2078
-0.6535
4
0
18
60.44
CC1=C2N=CC(=O)C2=CS1
Cc1scc2c1N=CC2=O
false
CC1CCC2C(C)CCC12
O=C1C=Nc2cscc21
151.19
41.5385
1.95512
3
0
15
29.43
CC1(NCS1(=O)=O)C1CO1
CC1(C2CO2)NCS1(=O)=O
false
CC1(C)CCC1(C)C1CC1
O=S1(=O)CNC1C1CO1
163.198
35.0675
-0.9231
4
1
19
58.7
NCC#CC1=CSC=C1Cl
NCC#Cc1cscc1Cl
false
CCCCC1CCCC1C
c1ccsc1
171.652
45.2614
1.7117
2
1
16
26.02
CNS(=O)(=O)N1CC1C#C
C#CC1CN1S(=O)(=O)NC
false
CCC1CC1C(C)(C)CC
C1CN1
160.198
37.3065
-1.232
2
1
18
49.18
CC1=NSC2=C1CC(=C)O2
C=C1Cc2c(C)nsc2O1
false
CC1CC2CCC(C)C2C1
C=C1Cc2cnsc2O1
153.206
40.323
1.90012
3
0
17
22.12
C1C2NCC3=C(SN=N3)C12
C1NC2CC2c2snnc21
false
C1CC2CCC3CC3C2C1
C1NC2CC2c2snnc21
153.21
37.8947
0.4972
4
1
17
37.81
NS(=O)(=O)CC1CC1C#C
C#CC1CC1CS(N)(=O)=O
false
CCC1CC1CC(C)(C)C
C1CC1
159.21
38.4042
-0.4558
2
1
19
60.16
C=CC#CC1=NSC(=O)N1
C=CC#Cc1nsc(=O)[nH]1
false
CCCCC1CCC(C)C1
O=c1[nH]cns1
152.178
39.8097
0.3689
3
1
14
45.75
OCC1=COS(=O)(=O)CC1
O=S1(=O)CCC(CO)=CO1
false
CCC1CCC(C)(C)CC1
O=S1(=O)CCC=CO1
164.182
34.6576
-0.3873
4
1
18
63.6
CCC=C(C)N(N)C(N)=S
CCC=C(C)N(N)C(N)=S
true
CCCC(C)C(C)C(C)C
159.258
46.8598
0.7195
2
2
23
55.28
OCC1=CC=C(O)C(Cl)=C1
OCc1ccc(O)c(Cl)c1
false
CCC1CCC(C)C(C)C1
c1ccccc1
158.584
39.0396
1.5379
2
2
17
40.46
CC1=NC(=C)S(=O)(=O)ON1
C=C1N=C(C)NOS1(=O)=O
false
CC1CCC(C)(C)C(C)C1
C=C1N=CNOS1(=O)=O
162.17
35.3895
-0.2594
5
1
16
67.76
OC(=O)C1CC2=NSC=C12
O=C(O)C1Cc2nscc21
false
CC(C)C1CC2CCCC21
c1snc2c1CC2
155.178
36.1948
0.8674
3
1
15
50.19
CC1=C2SC(=O)SN2C=C1
Cc1ccn2sc(=O)sc12
false
CC1CC2CCC(C)C2C1
O=c1sc2cccn2s1
171.246
44.158
1.73092
4
0
15
21.48
C#CC1=C2SC=CC2=CO1
C#Cc1occ2ccsc12
false
CCC1CCC2CCCC12
c1cc2cocc2s1
148.186
42.026
2.4756
2
0
14
13.14
CC1(CC1)ONS(N)(=O)=O
CC1(ONS(N)(=O)=O)CC1
false
CC(C)(C)CCC1(C)CC1
C1CC1
166.202
34.9669
-0.7364
3
2
20
81.42
CC#CC1=NOC(S1)=NN
CC#Cc1noc(=NN)s1
false
CCCC1CCC(CC)C1
N=c1oncs1
155.182
36.6824
-0.1181
5
1
15
64.41
NS(=O)(=O)C1CCN2CC12
NS(=O)(=O)C1CCN2CC12
true
CC(C)(C)C1CCC2CC21
C1CC2CN2C1
162.214
36.8732
-1.2686
3
1
20
63.17
CCC(CC)CS(O)(=O)=O
CCC(CC)CS(=O)(=O)O
false
CCC(CC)CC(C)(C)C
166.242
40.4876
1.3104
2
1
24
54.37
NC1=C(O)SC=C1C1CN1
Nc1c(C2CN2)csc1O
false
CC1CCC(C2CC2)C1C
c1cc(C2CN2)cs1
156.21
41.1399
0.6802
4
3
18
68.19
CN(C)C1=C(N)SC=C1O
CN(C)c1c(O)csc1N
false
CC(C)C1C(C)CCC1C
c1ccsc1
158.226
44.7232
1.1019
4
2
20
49.49
CCC#CC=CS(O)(=O)=O
CCC#CC=CS(=O)(=O)O
false
CCCCCCC(C)(C)C
160.194
38.7556
0.8013
2
1
18
54.37
OC(=O)C1=C2CNC2=CS1
O=C(O)c1scc2c1CN2
false
CC(C)C1CCC2CCC21
c1scc2c1CN2
155.178
38.605
1.3718
3
2
15
49.33
CNCC1=C(NC)C=CS1
CNCc1sccc1NC
false
CCCC1CCCC1CC
c1ccsc1
156.254
46.6294
1.5092
3
2
22
24.06
C1NC1C1OC2=NSC=C12
c1snc2c1C(C1CN1)O2
false
C1CC2CC(C3CC3)C2C1
c1snc2c1C(C1CN1)O2
154.194
37.2737
0.5484
4
1
16
44.06
NC1=C2NC(C=C)C2=CS1
C=CC1Nc2c1csc2N
false
CCC1CC2C(C)CCC12
c1scc2c1CN2
152.222
45.2921
1.9829
3
2
18
38.05