smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
CCNC(C)(C)S(C)(=O)=O
CCNC(C)(C)S(C)(=O)=O
true
CCCC(C)(C)C(C)(C)C
165.258
42.5995
0.3766
3
1
25
46.17
NC1=CC2=CC(Cl)=CN2O1
Nc1cc2cc(Cl)cn2o1
false
CC1CC2CC(C)CC2C1
c1cc2ccon2c1
156.572
39.0854
1.7679
3
1
15
43.57
CC=CS(=O)(=O)N1CCC1
CC=CS(=O)(=O)N1CCC1
true
CCCC(C)(C)C1CCC1
C1CNC1
161.226
39.9238
0.5555
2
0
21
37.38
CC=C(CO)C1=CSN=N1
CC=C(CO)c1csnn1
false
CCC(CC)C1CCCC1
c1csnn1
156.21
40.6458
0.9337
4
1
18
46.01
CC(=C)C(N)S(=O)(=O)NO
C=C(C)C(N)S(=O)(=O)NO
false
CCC(C)(C)C(C)C(C)C
166.202
36.6314
-0.8441
4
3
20
92.42
CC1=NC2=C(NC(=O)N2)S1
Cc1nc2[nH]c(=O)[nH]c2s1
false
CC1CC2CC(C)CC2C1
O=c1[nH]c2ncsc2[nH]1
155.182
39.3284
0.62112
3
2
15
61.54
CC1CN=C2NC(=O)SN12
CC1CN=C2NC(=O)SN21
false
CC1CC2CCC(C)C2C1
O=C1NC2=NCCN2S1
157.198
39.7257
0.4179
4
1
17
44.7
OC1C2OS(=O)(=O)C=CC12
O=S1(=O)C=CC2C(O)C2O1
false
CC1C2CCC(C)(C)CC12
O=S1(=O)C=CC2CC2O1
162.166
32.4296
-0.7806
4
1
16
63.6
CC1=NC2=C(S1)C(O)CC2
Cc1nc2c(s1)C(O)CC2
false
CC1CC2CCC(C)C2C1
c1nc2c(s1)CCC2
155.222
40.1318
1.43112
3
1
19
33.12
O=CCCOC1=CC=NS1
O=CCCOc1ccns1
false
CCCCCC1CCCC1
c1cnsc1
157.194
38.29
1.1109
4
0
17
39.19
C=CCC1=C(C=NS1)C#N
C=CCc1sncc1C#N
false
CCCC1CCCC1CC
c1cnsc1
150.206
40.73
1.74328
3
0
16
36.68
CC1CC(NC(N)=S)=NO1
CC1CC(NC(N)=S)=NO1
true
CC(C)CC1CCC(C)C1
C1=NOCC1
159.214
42.5201
-0.0581
3
2
19
59.64
NC(=S)NCC(O)C1CC1
NC(=S)NCC(O)C1CC1
true
CC(C)CCC(C)C1CC1
C1CC1
160.242
43.5189
-0.4095
2
3
22
58.28
CCC(N)S(=O)(=O)NOC
CCC(N)S(=O)(=O)NOC
true
CCCC(C)(C)C(C)CC
168.218
37.3309
-0.838
4
2
22
81.42
ClC1=COC2=C1C1CN1C2
Clc1coc2c1C1CN1C2
false
CC1CCC2CC3CC3C12
c1cc2c(o1)CN1CC21
155.584
36.869
1.8033
2
0
16
16.15
CCNN=C1SNC(C)=C1
CCNN=c1cc(C)[nH]s1
false
CCCCC1CCC(C)C1
N=c1cc[nH]s1
157.242
42.6464
0.80982
3
2
21
40.18
CCN1CC(NC1=S)C=O
CCN1CC(C=O)NC1=S
false
CCC1CC(C)C(CC)C1
S=C1NCCN1
158.226
42.8327
-0.2361
2
1
20
32.34
CN1OCC2CCN2C1=S
CN1OCC2CCN2C1=S
true
CC1CCC2CCC2C1C
S=C1NOCC2CCN12
158.226
41.424
0.2226
2
0
20
15.71
CCNC1=C(N)SC(=O)N1
CCNc1[nH]c(=O)sc1N
false
CCCC1CC(C)CC1C
O=c1[nH]ccs1
159.214
43.5158
0.4504
4
3
19
70.91
CC1C2CC1(C)NS2(=O)=O
CC1C2CC1(C)NS2(=O)=O
true
CC1C2CC1(C)CC2(C)C
O=S1(=O)NC2CC1C2
161.226
38.0295
0.0865
2
1
21
46.17
CCC1=C(C)OC(S1)=NN
CCc1sc(=NN)oc1C
false
CCC1CC(C)C(CC)C1
N=c1occs1
158.226
40.4504
0.98632
4
1
20
51.52
COCC1=CCS(=O)(=O)N1
COCC1=CCS(=O)(=O)N1
true
CCCC1CCC(C)(C)C1
O=S1(=O)CC=CN1
163.198
36.8815
-0.5503
3
1
19
55.4
CN=C1OS(=O)(=O)CN1C
CN=C1OS(=O)(=O)CN1C
true
CCC1CC(C)(C)CC1C
N=C1NCS(=O)(=O)O1
164.186
35.9938
-0.7785
4
0
18
58.97
N=C1C=CSN1C=CC#C
C#CC=Cn1sccc1=N
false
CCCCC1CCCC1C
N=c1ccs[nH]1
150.206
42.3267
1.13297
3
1
16
28.78
C#CCOCC1=NSN=N1
C#CCOCc1nnsn1
false
CCCCCC1CCCC1
c1nnsn1
155.182
36.193
0.0829
5
0
15
47.9
CONC(=S)N1CC1C#C
C#CC1CN1C(=S)NOC
false
CCCC(C)C1CC1CC
C1CN1
156.21
42.0697
-0.2603
2
1
18
24.27
CCCC1=C(SC=C1)C=O
CCCc1ccsc1C=O
false
CCCC1CCCC1CC
c1ccsc1
154.234
43.7015
2.5131
2
0
20
17.07
CCN(CCC#C)C(N)=S
C#CCCN(CC)C(N)=S
false
CCCCC(CC)C(C)C
156.254
47.4824
0.5752
1
1
22
29.26
CC=CN1C=CC(Cl)=C1O
CC=Cn1ccc(Cl)c1O
false
CCCC1CCC(C)C1C
c1cc[nH]c1
157.6
42.1108
2.3377
2
1
18
25.16
NS(=O)(=O)C1NC1C1CO1
NS(=O)(=O)C1NC1C1CO1
true
CC(C)(C)C1CC1C1CC1
C1NC1C1CO1
164.186
33.5589
-2.0284
4
2
18
94.63
C=C1CNS(=O)(=O)C11CC1
C=C1CNS(=O)(=O)C12CC2
false
CC1CCC(C)(C)C12CC2
C=C1CNS(=O)(=O)C12CC2
159.21
38.0275
0.0082
2
1
19
46.17
CC(C)C1=CC(C=C)=CS1
C=Cc1csc(C(C)C)c1
false
CCC1CCC(C(C)C)C1
c1ccsc1
152.262
48.499
3.5145
1
0
22
0
C=C(CC1=NSC=N1)C#C
C#CC(=C)Cc1ncsn1
false
CCC(C)CC1CCCC1
c1ncsn1
150.206
41.586
1.27
3
0
16
25.78
COC(=C)C1=CC(=N)SN1
C=C(OC)c1cc(=N)s[nH]1
false
CCC(C)C1CCC(C)C1
N=c1cc[nH]s1
156.21
40.5674
1.17277
3
2
18
48.87
OC1CS(=O)(=O)C1CC=C
C=CCC1C(O)CS1(=O)=O
false
CCCC1C(C)CC1(C)C
O=S1(=O)CCC1
162.21
38.3956
-0.2796
3
1
20
54.37
CCNC1=C(C)SC(=O)N1
CCNc1[nH]c(=O)sc1C
false
CCCC1CC(C)CC1C
O=c1[nH]ccs1
158.226
43.8404
1.17662
3
2
20
44.89
CCCNS(=O)(=O)C=CC
CC=CS(=O)(=O)NCCC
false
CCCCC(C)(C)CCC
163.242
42.0275
0.8494
2
1
23
46.17
O=S1(=O)CCC2OC2CC1
O=S1(=O)CCC2OC2CC1
true
CC1(C)CCC2CC2CC1
O=S1(=O)CCC2OC2CC1
162.21
36.5488
-0.0376
3
0
20
46.67
CCONS(=O)(=O)C1CC1
CCONS(=O)(=O)C1CC1
true
CCCCC(C)(C)C1CC1
C1CC1
165.214
36.7035
0.0197
3
1
21
55.4
CNC(=O)CC1=CC=CS1
CNC(=O)Cc1cccs1
false
CCC(C)CC1CCCC1
c1ccsc1
155.222
42.0897
1.0366
2
1
19
29.1
CS(=O)(=O)C1=CCN2CC12
CS(=O)(=O)C1=CCN2CC12
true
CC(C)(C)C1CCC2CC21
C1=CC2CN2C1
159.21
38.2878
-0.3873
3
0
19
37.15
CC1C2OC2(C)CS1(=O)=O
CC1C2OC2(C)CS1(=O)=O
true
CC1C2CC2(C)CC1(C)C
O=S1(=O)CC2OC2C1
162.21
36.5268
-0.0392
3
0
20
46.67
CC(O)CNC1=CSN=N1
CC(O)CNc1csnn1
false
CC(C)CCC1CCCC1
c1csnn1
159.214
40.0795
0.3308
5
2
19
58.04
O=S(=O)(C#N)N1CCN=C1
N#CS(=O)(=O)N1C=NCC1
false
CCC(C)(C)C1CCCC1
C1=NCCN1
159.17
34.5978
-0.85882
4
0
15
73.53
CC(O)C(=C)S(=O)(=O)C#N
C=C(C(C)O)S(=O)(=O)C#N
false
CCC(C)(C)C(C)C(C)C
161.182
35.3536
-0.22322
4
1
17
78.16
CC1NN=CC1S(C)(=O)=O
CC1NN=CC1S(C)(=O)=O
true
CC1CCCC1C(C)(C)C
C1=NNCC1
162.214
39.7215
-0.6229
4
1
20
58.53
CC1CS(=O)(=O)CC=C1C
CC1=CCS(=O)(=O)CC1C
false
CC1CCC(C)(C)CC1C
O=S1(=O)CC=CCC1
160.238
41.5748
0.9972
2
0
22
34.14
ON1C(=C)CN(C=C)C1=S
C=CN1CC(=C)N(O)C1=S
false
CCC1CC(C)C(C)C1C
C=C1CNC(=S)N1
156.21
42.2665
0.9353
2
1
18
26.71
COC1=C(C)SC(CO)=N1
COc1nc(CO)sc1C
false
CCC1CC(C)C(CC)C1
c1cscn1
159.21
39.3258
0.95242
4
1
19
42.35
CC1=CSC=C1C(=O)NO
Cc1cscc1C(=O)NO
false
CCC(C)C1CCCC1C
c1ccsc1
157.194
38.3087
1.17552
3
2
17
49.33
CC1=NN=C(S1)C#CC#N
Cc1nnc(C#CC#N)s1
false
CCCCC1CCC(C)C1
c1nncs1
149.178
37.137
0.7216
4
0
13
49.57
CC(=C)C1=CC(Cl)=C(N)O1
C=C(C)c1cc(Cl)c(N)o1
false
CC(C)C1CC(C)C(C)C1
c1ccoc1
157.6
42.8384
2.5483
2
1
18
39.16
C=C1C(=O)CC2=C1SN=N2
C=C1C(=O)Cc2nnsc21
false
CC1CC2CCCC2C1C
C=C1C(=O)Cc2nnsc21
152.178
37.654
0.6765
4
0
14
42.85
CC1COS(=O)(=O)CCN1
CC1COS(=O)(=O)CCN1
true
CC1CCCC(C)(C)CC1
O=S1(=O)CCNCCO1
165.214
37.2035
-0.6755
4
1
21
55.4
OC1=CSC=C1C=CC=O
O=CC=Cc1cscc1O
false
CCCCC1CCCC1C
c1ccsc1
154.19
41.0818
1.6658
3
1
16
37.3
CNC1=C(SC(C)=N1)C=C
C=Cc1sc(C)nc1NC
false
CCC1CC(C)CC1CC
c1cscn1
154.238
46.4887
2.13622
3
1
20
24.92
CC(O)(C=C)C1=CN=NS1
C=CC(C)(O)c1cnns1
false
CCC(C)(C)C1CCCC1
c1csnn1
156.21
39.6768
0.9316
4
1
18
46.01
NN(C(N)=S)C1=CCCO1
NC(=S)N(N)C1=CCCO1
false
CC(C)C(C)C1CCCC1
C1=COCC1
159.214
41.4638
-0.3326
3
2
19
64.51
O=S1(=O)CCNCC11CO1
O=S1(=O)CCNCC12CO2
false
CC1(C)CCCCC12CC2
O=S1(=O)CCNCC12CO2
163.198
35.3395
-1.2691
4
1
19
58.7
CCNC1=CSN(C)C1=N
CCNc1csn(C)c1=N
false
CCCC1CCC(C)C1C
N=c1ccs[nH]1
157.242
43.3084
0.99787
4
2
21
40.81
CCCN1C=CC(Cl)=C1N
CCCn1ccc(Cl)c1N
false
CCCC1CCC(C)C1C
c1cc[nH]c1
158.632
44.1454
2.1337
2
1
21
30.95
CN1C=NC2=C(C)SN=C12
Cc1snc2c1ncn2C
false
CC1CCC2C(C)CCC12
c1nc2csnc2[nH]1
153.21
41.123
1.33822
4
0
17
30.71
CC(CO)C#CS(N)(=O)=O
CC(C#CS(N)(=O)=O)CO
false
CCC(C)CCC(C)(C)C
163.198
37.133
-1.1358
3
2
19
80.39
O=S1(=O)C2COC1C2C#N
N#CC1C2COC1S2(=O)=O
false
CCC1C2CCC1C2(C)C
O=S1(=O)C2COC1C2
159.166
31.5508
-0.72052
4
0
15
67.16
NC=C1CCC=CS1(=O)=O
NC=C1CCC=CS1(=O)=O
true
CCC1CCCCC1(C)C
C=C1CCC=CS1(=O)=O
159.21
39.5642
0.5088
3
1
19
60.16
CC1NN=C(C)CS1(=O)=O
CC1=NNC(C)S(=O)(=O)C1
false
CC1CCC(C)C(C)(C)C1
O=S1(=O)CC=NNC1
162.214
39.4935
-0.2737
4
1
20
58.53
CCC12CN1C(=S)N(C)C2
CCC12CN(C)C(=S)N1C2
false
CCC12CC(C)C(C)C1C2
S=C1NCC2CN12
156.254
44.956
0.6811
1
0
22
6.25
CC(CN)=CC1=CSC=N1
CC(=Cc1cscn1)CN
false
CCC(C)CC1CCCC1
c1cscn1
154.238
44.8194
1.5051
3
1
20
38.91
CC#CS(=O)(=O)CN1CC1
CC#CS(=O)(=O)CN1CC1
true
CCCC(C)(C)CC1CC1
C1CN1
159.21
38.8098
-0.3449
3
0
19
37.15
COC(C)C1=C(N)C=NS1
COC(C)c1sncc1N
false
CCC(C)C1CCCC1C
c1cnsc1
158.226
41.9504
1.4327
4
1
20
48.14
CCN1CC2(C)CN2C1=S
CCN1CC2(C)CN2C1=S
true
CCC1CC2(C)CC2C1C
S=C1NCC2CN12
156.254
44.956
0.6811
1
0
22
6.25
CNC1=C(C)SC(=C1)C#C
C#Cc1cc(NC)c(C)s1
false
CCC1CC(C)C(CC)C1
c1ccsc1
151.234
46.5377
2.07952
2
1
19
12.03
CC(=O)CC1=C(O)SC=N1
CC(=O)Cc1ncsc1O
false
CC(C)CC1CCCC1C
c1cscn1
157.194
38.1638
0.9802
4
1
17
50.19
CCC1NNS(=O)(=O)C1O
CCC1NNS(=O)(=O)C1O
true
CCC1CCC(C)(C)C1C
O=S1(=O)CCNN1
166.202
35.277
-1.479
4
3
20
78.43
CC(=N)N1SC(C)=CC1=O
CC(=N)n1sc(C)cc1=O
false
CC1CC(C)C(C(C)C)C1
O=c1ccs[nH]1
156.21
42.1147
1.06349
4
1
18
45.85
C#CC1=COC2=CSN=C12
C#Cc1coc2csnc12
false
CCC1CCC2CCCC12
c1cc2nscc2o1
149.174
39.821
1.8706
3
0
13
26.03
CC1C(C#C)S(=O)(=O)N1N
C#CC1C(C)N(N)S1(=O)=O
false
CCC1C(C)C(C)C1(C)C
O=S1(=O)CCN1
160.198
37.0292
-1.1042
3
1
18
63.4
CC(C)C#CCNC(N)=S
CC(C)C#CCNC(N)=S
true
CC(C)CCCCC(C)C
156.254
47.4021
0.479
1
2
22
38.05
O=S1(=O)CCC2(CC2)ON1
O=S1(=O)CCC2(CC2)ON1
true
CC1(C)CCC2(CC1)CC2
O=S1(=O)CCC2(CC2)ON1
163.198
34.5895
-0.2263
3
1
19
55.4
C=C1CN2CC2S(=O)(=O)C1
C=C1CN2CC2S(=O)(=O)C1
true
CC1CC2CC2C(C)(C)C1
C=C1CN2CC2S(=O)(=O)C1
159.21
38.2878
-0.3873
3
0
19
37.15
CC1=CSC=C1NCC#N
Cc1cscc1NCC#N
false
CCCCC1CCCC1C
c1ccsc1
152.222
43.1587
1.992
3
1
18
35.82
CCOC1=C(CC)N=NS1
CCOc1snnc1CC
false
CCCC1CCCC1CC
c1csnn1
158.226
40.456
1.4992
4
0
20
35.01
CC(C)(O)CC1=NSC=C1
CC(C)(O)Cc1ccsn1
false
CC(C)(C)CC1CCCC1
c1cnsc1
157.238
42.1158
1.4565
3
1
21
33.12
CC1=CC(=C)C(=C)S1(=O)=O
C=C1C=C(C)S(=O)(=O)C1=C
false
CC1CC(C)C(C)(C)C1C
C=C1C=CS(=O)(=O)C1=C
156.206
40.9568
1.3885
2
0
18
34.14
OS(=O)(=O)C(C=C)C1CO1
C=CC(C1CO1)S(=O)(=O)O
false
CCC(C1CC1)C(C)(C)C
C1CO1
164.182
35.2736
-0.1724
3
1
18
66.9
CN(N=CN)S(=O)(=O)C#C
C#CS(=O)(=O)N(C)N=CN
false
CCCC(C)C(C)(C)CC
161.186
38.1952
-1.2593
3
1
17
75.76
CNN(C=C)S(=O)(=O)CN
C=CN(NC)S(=O)(=O)CN
false
CCC(CC)C(C)(C)CC
165.218
39.0699
-1.1877
4
2
21
75.43
CNC(C)C1=C(N)C=NS1
CNC(C)c1sncc1N
false
CCC(C)C1CCCC1C
c1cnsc1
157.242
44.0011
1.0057
4
2
21
50.94
NN1C2CC(C2)OS1(=O)=O
NN1C2CC(C2)OS1(=O)=O
true
CC1C2CC(C2)CC1(C)C
O=S1(=O)NC2CC(C2)O1
164.186
32.8412
-1.0319
4
1
18
72.63
CC1C(N)C(=C)NS1(=O)=O
C=C1NS(=O)(=O)C(C)C1N
false
CC1CC(C)(C)C(C)C1C
C=C1CCS(=O)(=O)N1
162.214
38.6329
-0.8511
3
2
20
72.19
CC1=NSN=C1C#CC=O
Cc1nsnc1C#CC=O
false
CCCCC1CCCC1C
c1cnsn1
152.178
37.588
0.39692
4
0
14
42.85
O=S1(=O)CCC2=CC=CC12
O=S1(=O)CCC2=CC=CC21
false
CC1(C)CCC2CCCC21
O=S1(=O)CCC2=CC=CC21
156.206
39.4148
0.6697
2
0
18
34.14
CCC(=C)C(=O)S(C)(=O)=O
C=C(CC)C(=O)S(C)(=O)=O
false
CCC(C)C(C)C(C)(C)C
162.21
39.2818
0.5238
3
0
20
51.21
COCC1=C(C)SC(C)=N1
COCc1nc(C)sc1C
false
CCCC1CC(C)CC1C
c1cscn1
157.238
42.301
1.90634
3
0
21
22.12
CN1SC=C2C(C)=NN=C12
Cc1nnc2n(C)scc1-2
false
CC1CCC2C(C)CCC12
c1nnc2[nH]scc1-2
153.21
40.239
1.28982
4
0
17
30.71
CCNN1N=CC(Cl)=C1O
CCNn1ncc(Cl)c1O
false
CCCC1CCC(C)C1C
c1cn[nH]c1
161.592
38.8035
0.8055
4
2
18
50.08
CNCC1=CSC(N1)=NO
CNCc1csc(=NO)[nH]1
false
CCCC1CCC(CC)C1
N=c1[nH]ccs1
159.214
38.7829
0.0855
4
3
19
60.41
ON1C(=S)NCC(=C)C1=C
C=C1CNC(=S)N(O)C1=C
false
CC1CCC(C)C(C)C1C
C=C1CNC(=S)NC1=C
156.21
42.5062
0.6356
2
2
18
35.5
CC1(CS(=O)(=O)N1)C1CO1
CC1(C2CO2)CS(=O)(=O)N1
false
CC1(C)CC(C)(C2CC2)C1
O=S1(=O)CC(C2CO2)N1
163.198
35.0675
-0.9231
3
1
19
58.7
CC1=C(OC2CC2)N=NS1
Cc1snnc1OC1CC1
false
CC1CCCC1CC1CC1
c1snnc1OC1CC1
156.21
38.296
1.38772
4
0
18
35.01