smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
NC1=CS(=O)(=O)C=CCC1
NC1=CS(=O)(=O)C=CCC1
true
CC1CCCCC(C)(C)C1
O=S1(=O)C=CCCC=C1
159.21
39.5642
0.5088
3
1
19
60.16
NC1=CC2=C(S1)C=COC2
Nc1cc2c(s1)C=COC2
false
CC1CC2CCCCC2C1
C1=Cc2sccc2CO1
153.206
42.5544
1.8312
3
1
17
35.25
CC1CS(=O)(=O)C(N1)=NO
CC1CS(=O)(=O)C(=NO)N1
false
CCC1CC(C)CC1(C)C
N=C1NCCS1(=O)=O
164.186
35.606
-0.8619
4
2
18
78.76
C#CC1=NSN=C1N1CC1
C#Cc1nsnc1N1CC1
false
CCC1CCCC1C1CC1
c1nsnc1N1CC1
151.194
40.057
0.3394
4
0
15
28.79
CS(=O)(=O)NCC(N)CO
CS(=O)(=O)NCC(N)CO
true
CCC(C)CCC(C)(C)C
168.218
37.9077
-2.1448
4
3
22
92.42
CC1=C2NC(=O)SC2=CS1
Cc1scc2sc(=O)[nH]c12
false
CC1CC2CCC(C)C2C1
O=c1[nH]c2cscc2s1
171.246
45.0597
1.95952
3
1
15
32.86
NCCC1=CSN=C1C=C
C=Cc1nscc1CCN
false
CCCC1CCCC1CC
c1cnsc1
154.238
44.9634
1.2873
3
1
20
38.91
CC1NS(=O)(=O)C1(O)C=C
C=CC1(O)C(C)NS1(=O)=O
false
CCC1(C)C(C)CC1(C)C
O=S1(=O)CCN1
163.198
36.6643
-0.8175
3
2
19
66.4
N=C1NCC2=C(O1)C=CS2
N=C1NCc2sccc2O1
false
CC1CCC2CCCC2C1
N=C1NCc2sccc2O1
154.194
39.5134
1.16487
3
2
16
45.11
S1C=C2C(=C1)C1=CSC=C21
c1scc2c1-c1cscc1-2
false
C1CC2C(C1)C1CCCC21
c1scc2c1-c1cscc1-2
164.254
46.626
3.457
2
0
14
0
O=S1(=O)CC2CC(O1)C=C2
O=S1(=O)CC2C=CC(C2)O1
false
CC1(C)CC2CCC(C2)C1
O=S1(=O)CC2C=CC(C2)O1
160.194
35.9068
0.2911
3
0
18
43.37
CC=CC=CS(=O)(=O)C=O
CC=CC=CS(=O)(=O)C=O
true
CCCCCC(C)(C)CC
160.194
39.6243
0.6812
3
0
18
51.21
COC(OC)C1=NC=CS1
COC(OC)c1nccs1
false
CCC(CC)C1CCCC1
c1cscn1
159.21
38.873
1.4345
4
0
19
31.35
CC1(C)CN=CNS1(=O)=O
CC1(C)CN=CNS1(=O)=O
true
CC1(C)CCCCC1(C)C
O=S1(=O)CCN=CN1
162.214
39.4935
-0.2737
3
1
20
58.53
CC(=C)C(=O)C1=CC=CS1
C=C(C)C(=O)c1cccs1
false
CC(C)C(C)C1CCCC1
c1ccsc1
152.218
43.4635
2.5069
2
0
18
17.07
CN=C1CS(=O)(=O)C(=O)N1
CN=C1CS(=O)(=O)C(=O)N1
true
CCC1CC(C)C(C)(C)C1
N=C1CS(=O)(=O)C(=O)N1
162.17
35.6775
-0.8473
4
1
16
75.6
CC1C2NC(=S)NC(=C)C12
C=C1NC(=S)NC2C(C)C12
false
CC1CC(C)C2C(C)C2C1
C=C1NC(=S)NC2CC12
154.238
44.4514
0.6123
1
2
20
24.06
CC1=NC(CCC=C)=CS1
C=CCCc1csc(C)n1
false
CCCCC1CCC(C)C1
c1cscn1
153.25
45.369
2.57012
2
0
21
12.89
CC=C1CC(=C)S(=O)(=O)O1
C=C1CC(=CC)OS1(=O)=O
false
CCC1CC(C)C(C)(C)C1
C=C1CC(=C)S(=O)(=O)O1
160.194
37.5188
1.154
3
0
18
43.37
C1OC1C1=C2NCC2=CS1
c1sc(C2CO2)c2c1CN2
false
C1CC1C1CCC2CCC21
c1sc(C2CO2)c2c1CN2
153.206
40.3387
1.7449
3
1
17
24.56
N1C2C=CC3=C(N=CS3)C12
C1=CC2NC2c2ncsc21
false
C1CC2CCC3CC3C2C1
C1=CC2NC2c2ncsc21
150.206
40.8127
1.1828
3
1
16
34.83
CN(C(C)=N)C1=NC=CS1
CC(=N)N(C)c1nccs1
false
CC(C)C(C)C1CCCC1
c1cscn1
155.226
43.9177
1.57647
3
1
19
39.98
CN1C(=O)NC=C(Cl)C1=N
Cn1c(=O)[nH]cc(Cl)c1=N
false
CC1CCC(C)C(C)C1C
N=c1cc[nH]c(=O)[nH]1
159.576
36.8984
-0.15373
3
2
16
61.64
CN1C2C(N)C2CNC1=S
CN1C(=S)NCC2C(N)C21
false
CC1CCC2C(C)C2C1C
S=C1NCC2CC2N1
157.242
43.6171
-0.868
2
2
21
41.29
CC1C2CN2C(=O)S1(=O)=O
CC1C2CN2C(=O)S1(=O)=O
true
CC1C2CC2C(C)C1(C)C
O=C1N2CC2CS1(=O)=O
161.182
34.2718
-0.3925
3
0
17
54.22
NC(=N)C1=NC(=CS1)C#C
C#Cc1csc(C(=N)N)n1
false
CCC1CCC(C(C)C)C1
c1cscn1
151.194
41.0651
0.40847
3
2
15
62.76
CNC1=C(C)SC(OC)=N1
CNc1nc(OC)sc1C
false
CCC1CC(C)C(CC)C1
c1cscn1
158.226
42.9497
1.50182
4
1
20
34.15
CS(=O)(=O)C1=CN(O)N=C1
CS(=O)(=O)c1cnn(O)c1
false
CC1CCC(C(C)(C)C)C1
c1cn[nH]c1
162.17
32.5213
-0.4761
5
1
16
72.19
CNC(C)(C)C1=NC=NS1
CNC(C)(C)c1ncns1
false
CCC(C)(C)C1CCCC1
c1ncsn1
157.242
41.9947
0.9926
4
1
21
37.81
CN1C2CC1S(=O)(=O)CC2
CN1C2CCS(=O)(=O)C1C2
false
CC1C2CCC(C)(C)C1C2
O=S1(=O)CCC2CC1N2
161.226
38.3598
-0.1649
3
0
21
37.38
NC1=C(O)C=C(CC#C)S1
C#CCc1cc(O)c(N)s1
false
CCCC1CC(C)C(C)C1
c1ccsc1
153.206
42.9332
1.2116
3
2
17
46.25
CC1(CN1)C1=NC=C(N)S1
CC1(c2ncc(N)s2)CN1
false
CC1CCC(C2(C)CC2)C1
c1csc(C2CN2)n1
155.226
41.8811
0.5437
4
2
19
60.85
CCC=C(C)S(=O)(=O)NC
CCC=C(C)S(=O)(=O)NC
true
CCCC(C)C(C)(C)CC
163.242
42.0275
0.8494
2
1
23
46.17
CC1(O)CNS(=O)(=O)NC1
CC1(O)CNS(=O)(=O)NC1
true
CC1(C)CCC(C)(C)CC1
O=S1(=O)NCCCN1
166.202
35.549
-1.825
3
3
20
78.43
CC(C)(C1CC1)S(N)(=O)=O
CC(C)(C1CC1)S(N)(=O)=O
true
CC(C)(C)C(C)(C)C1CC1
C1CC1
163.242
39.9102
0.4635
2
1
23
60.16
CC(=C)OC1=C(N)C=NS1
C=C(C)Oc1sncc1N
false
CC(C)CC1CCCC1C
c1cnsc1
156.21
41.9684
1.6377
4
1
18
48.14
CCC(=O)C1=C(N)C=CS1
CCC(=O)c1sccc1N
false
CCC(C)C1CCCC1C
c1ccsc1
155.222
43.3529
1.923
3
1
19
43.09
CC(C)NN1SC(=O)N=C1
CC(C)Nn1cnc(=O)s1
false
CC(C)CC1CCC(C)C1
O=c1nc[nH]s1
159.214
40.8707
0.2567
5
1
19
46.92
CCC=CS(=O)(=O)NN=C
C=NNS(=O)(=O)C=CCC
false
CCCCC(C)(C)CCC
162.214
41.0355
0.4451
3
1
20
58.53
N#CC1CCC2=C1N=CS2
N#CC1CCc2scnc21
false
CCC1CCC2CCCC12
c1nc2c(s1)CCC2
150.206
38.789
1.69648
3
0
16
36.68
CC1ON=CC1S(N)(=O)=O
CC1ON=CC1S(N)(=O)=O
true
CC1CCCC1C(C)(C)C
C1=NOCC1
164.186
35.9342
-0.952
4
1
18
81.75
N=C1NC(=S)NC11CCC1
N=C1NC(=S)NC12CCC2
false
CC1CC(C)C2(CCC2)C1
N=C1NC(=S)NC12CCC2
155.226
43.1781
0.36407
2
3
19
47.91
NC1=CC(Cl)=C(N)C(=N)O1
N=c1oc(N)cc(Cl)c1N
false
CC1CC(C)C(C)C(C)C1
N=c1cccco1
159.576
38.3975
0.57687
4
3
16
89.03
CC1=C(OC(N)=N)SN=C1
Cc1cnsc1OC(=N)N
false
CC(C)CC1CCCC1C
c1cnsc1
157.198
39.3931
0.72379
4
2
17
71.99
CC=CC1OS(=O)(=O)C1O
CC=CC1OS(=O)(=O)C1O
true
CCCC1CC(C)(C)C1C
O=S1(=O)CCO1
164.182
34.6136
-0.3905
4
1
18
63.6
CCS(=O)(=O)N1C=CC=N1
CCS(=O)(=O)n1cccn1
false
CCC(C)(C)C1CCCC1
c1cn[nH]c1
160.198
37.0858
0.0809
4
0
18
51.96
CC1C=CC=COS1(=O)=O
CC1C=CC=COS1(=O)=O
true
CC1CCCCCC1(C)C
O=S1(=O)CC=CC=CO1
160.194
37.7468
0.8048
3
0
18
43.37
CCC1=C(NC(=O)S1)OC
CCc1sc(=O)[nH]c1OC
false
CCC1CC(C)CC1CC
O=c1[nH]ccs1
159.21
40.8697
1.0074
3
1
19
42.09
CC(C)(N)C1=C(Cl)C=CS1
CC(C)(N)c1sccc1Cl
false
CC1CCCC1C(C)(C)C
c1ccsc1
175.684
46.5424
2.5953
2
1
20
26.02
C=C1CNCC2=C1C=NS2
C=C1CNCc2sncc21
false
CC1CCCC2CCCC12
C=C1CNCc2sncc21
152.222
42.8547
1.2595
3
1
18
24.92
O=S1(=O)C2CCC1CNC2
O=S1(=O)C2CCC1CNC2
true
CC1(C)C2CCCC1CC2
O=S1(=O)C2CCC1CNC2
161.226
38.5995
-0.4646
3
1
21
46.17
CC1NCC2OC2S1(=O)=O
CC1NCC2OC2S1(=O)=O
true
CC1CCC2CC2C1(C)C
O=S1(=O)CNCC2OC21
163.198
35.0455
-0.9247
4
1
19
58.7
NC1=CC2=C(C=CS2)N=N1
Nc1cc2sccc2nn1
false
CC1CCC2CCCC2C1
c1cc2sccc2nn1
151.194
41.8274
1.2735
4
1
15
51.8
NC1CON(C=C)S1(=O)=O
C=CN1OCC(N)S1(=O)=O
false
CCC1CCC(C)C1(C)C
O=S1(=O)CCON1
164.186
34.8832
-1.0083
4
1
18
72.63
CC(C#C)C1=CC=C(N)S1
C#CC(C)c1ccc(N)s1
false
CCC(C)C1CCC(C)C1
c1ccsc1
151.234
45.9794
2.067
2
1
19
26.02
CC1=NCC2CS(=O)(=O)N12
CC1=NCC2CS(=O)(=O)N12
true
CC1CCC2CC(C)(C)C12
O=S1(=O)CC2CN=CN21
160.198
37.3898
-0.5676
3
0
18
49.74
CN1SC(C=NN)=CC1=O
Cn1sc(C=NN)cc1=O
false
CCCC1CC(C)C(C)C1
O=c1ccs[nH]1
157.198
41.3414
-0.2606
5
1
17
60.38
NC1CN2C1=CC(Cl)=C2N
Nc1c(Cl)cc2n1CC2N
false
CC1CC2C(C)CC2C1C
c1cc2n(c1)CC2
157.604
40.7828
0.7371
3
2
18
56.97
NC1CC(=C)C2=NSC=C12
C=C1CC(N)c2csnc21
false
CC1CC(C)C2CCCC12
C=C1CCc2csnc21
152.222
42.6934
1.5598
3
1
18
38.91
CC1=C(C2CO2)C(N)=NS1
Cc1snc(N)c1C1CO1
false
CC1CCC(C)C1C1CC1
c1nscc1C1CO1
156.21
39.9564
1.10502
4
1
18
51.44
CCC=CCCS(N)(=O)=O
CCC=CCCS(N)(=O)=O
true
CCCCCCC(C)(C)C
163.242
42.0222
0.6312
2
1
23
60.16
CC1C2OC(C2O)S1(=O)=O
CC1C2OC(C2O)S1(=O)=O
true
CC1C2CC1C(C)(C)C2C
O=S1(=O)CC2CC1O2
164.182
33.0496
-1.1109
4
1
18
63.6
CCCN(O)S(=O)(=O)C=C
C=CS(=O)(=O)N(O)CCC
false
CCCC(C)C(C)(C)CC
165.214
37.9003
0.5609
3
1
21
57.61
CC1=C(SC=N1)C#CC=C
C=CC#Cc1scnc1C
false
CCCCC1CCCC1C
c1cscn1
149.218
43.926
1.98902
2
0
17
12.89
ClC1=CC(=O)N(C=C1)N=C
C=Nn1ccc(Cl)cc1=O
false
CCC1CCC(C)CC1C
O=c1cccc[nH]1
156.572
40.659
0.9654
3
0
15
34.36
CCNCCC1=CSN=C1
CCNCCc1cnsc1
false
CCCCCC1CCCC1
c1cnsc1
156.254
44.3617
1.2951
3
1
22
24.92
NCC1CC1C1=NSC=N1
NCC1CC1c1ncsn1
false
CCC1CC1C1CCCC1
c1nc(C2CC2)ns1
155.226
39.8114
0.6003
4
1
19
51.8
NC1CCC2=C1NC(=O)S2
NC1CCc2sc(=O)[nH]c21
false
CC1CC2CCC(C)C2C1
O=c1[nH]c2c(s1)CCC2
156.21
40.1891
0.3824
3
2
18
58.88
OCC1=C(NC=O)C=CS1
O=CNc1ccsc1CO
false
CCCC1CCCC1CC
c1ccsc1
157.194
39.9285
0.8087
3
2
17
49.33
N=C1SC=C2C=CC(=N)N12
N=C1C=Cc2csc(=N)n21
false
CC1CCC2CCC(C)C12
N=C1C=Cc2csc(=N)n21
151.194
40.3224
0.88124
4
2
15
52.63
CC=C1CON(C)C(=S)N1
CC=C1CON(C)C(=S)N1
true
CCC1CCC(C)C(C)C1
C=C1CONC(=S)N1
158.226
43.2057
0.6417
2
1
20
24.5
CS(=O)(=O)NC(C=O)C#C
C#CC(C=O)NS(C)(=O)=O
false
CCC(CC)CC(C)(C)C
161.182
36.6645
-1.2637
3
1
17
63.24
CC=CC1=C(O)SC(O)=C1
CC=Cc1cc(O)sc1O
false
CCCC1CC(C)CC1C
c1ccsc1
156.206
42.3566
2.1924
3
2
18
40.46
NC(=N)CNS(=O)(=O)C#C
C#CS(=O)(=O)NCC(=N)N
false
CCC(C)(C)CCC(C)C
161.186
37.6696
-1.56753
3
3
17
96.04
CC1=NOC(N2CC2)=C1Cl
Cc1noc(N2CC2)c1Cl
false
CC1CCC(C2CC2)C1C
c1cc(N2CC2)on1
158.588
38.463
1.45642
3
0
17
29.04
ON=C1CNC=CS1(=O)=O
O=S1(=O)C=CNCC1=NO
false
CCC1CCCCC1(C)C
N=C1CNC=CS1(=O)=O
162.17
35.284
-0.7367
5
2
16
78.76
C=NN=CCC1=NC=CS1
C=NN=CCc1nccs1
false
CCCCCC1CCCC1
c1cscn1
153.21
43.859
1.372
4
0
17
37.61
O=CC=C1CNNC(=S)N1
O=CC=C1CNNC(=S)N1
true
CCCC1CCCC(C)C1
C=C1CNNC(=S)N1
157.198
41.0191
-0.9485
3
3
17
53.16
CN1N=C(SC1=O)C1CN1
Cn1nc(C2CN2)sc1=O
false
CC1CC(C2CC2)CC1C
O=c1[nH]nc(C2CN2)s1
157.198
38.0987
-0.5139
5
1
17
56.83
C=CS(=O)(=O)C(=O)CC=O
C=CS(=O)(=O)C(=O)CC=O
true
CCCC(C)C(C)(C)CC
162.166
34.8048
-0.3397
4
0
16
68.28
NC(CC=C)C1=NC=NS1
C=CCC(N)c1ncns1
false
CCCC(C)C1CCCC1
c1ncsn1
155.226
41.6514
1.114
4
1
19
51.8
CCONC(=S)N(C)C=N
CCONC(=S)N(C)C=N
true
CCCCC(C)C(C)CC
161.23
43.9064
0.35127
3
2
21
48.35
O=S1(=O)NNCC2CC2N1
O=S1(=O)NNCC2CC2N1
true
CC1(C)CCCC2CC2C1
O=S1(=O)NNCC2CC2N1
163.202
35.0889
-1.6829
3
3
19
70.23
C(NC1=CSC=N1)C1CC1
c1nc(NCC2CC2)cs1
false
C1CCC(CCC2CC2)C1
c1nc(NCC2CC2)cs1
154.238
43.3277
1.965
3
1
20
24.92
CNS(=O)(=O)C(C)CC=C
C=CCC(C)S(=O)(=O)NC
false
CCCC(C)C(C)(C)CC
163.242
42.2555
0.5002
2
1
23
46.17
CC1=CSC(C=NN)=C1C
Cc1csc(C=NN)c1C
false
CCCC1CCC(C)C1C
c1ccsc1
154.238
45.5744
1.65754
3
1
20
38.38
CS(=O)(=O)C(CC=O)C#N
CS(=O)(=O)C(C#N)CC=O
false
CCCC(CC)C(C)(C)C
161.182
34.9258
-0.48782
4
0
17
75
CS(=O)(=O)C1=CCNN=C1
CS(=O)(=O)C1=CCNN=C1
true
CC(C)(C)C1CCCCC1
C1=CCNN=C1
160.198
39.4215
-0.4961
4
1
18
58.53
CN=C1N(O)SC=C1CN
CN=c1c(CN)csn1O
false
CCC1CCC(C)C1CC
N=c1ccs[nH]1
159.214
38.8719
-0.2239
5
2
19
63.54
ON1C(CS1(=O)=O)C1CN1
O=S1(=O)CC(C2CN2)N1O
false
CC1C(C2CC2)CC1(C)C
O=S1(=O)CC(C2CN2)N1
164.186
32.991
-1.6386
4
2
18
79.55
O=CNC(=S)N1CC1C#C
C#CC1CN1C(=S)NC=O
false
CCCC(C)C1CC1CC
C1CN1
154.194
41.1247
-0.6653
2
1
16
32.11
C1NCC(=C1)C1=CC=NS1
C1=C(c2ccns2)CNC1
false
C1CCC(C2CCCC2)C1
C1=C(c2ccns2)CNC1
152.222
42.9607
1.1297
3
1
18
24.92
CC1=NSC=C1C(O)CN
Cc1nscc1C(O)CN
false
CCC(C)C1CCCC1C
c1cnsc1
158.226
40.8652
0.44362
4
2
20
59.14
NC(=S)N1CCCCCO1
NC(=S)N1CCCCCO1
true
CC(C)C1CCCCCC1
C1CCNOCC1
160.242
43.2944
0.6475
2
1
22
38.49
OCCC1NC2=NSC=C12
OCCC1Nc2nscc21
false
CCCC1CC2CCCC12
c1snc2c1CN2
156.21
40.1805
0.9921
4
2
18
45.15
CC1=C2NCC=CC2=NS1
Cc1snc2c1NCC=C2
false
CC1CCC2CCCCC12
C1=Cc2nscc2NC1
152.222
44.3747
1.89022
3
1
18
24.92
NS(=O)(=O)CC1CC=NO1
NS(=O)(=O)CC1CC=NO1
true
CC(C)(C)CC1CCCC1
C1=NOCC1
164.186
35.9562
-0.9504
4
1
18
81.75
CCN(C)CS(=O)(=O)C=O
CCN(C)CS(=O)(=O)C=O
true
CCC(C)CC(C)(C)CC
165.214
38.8413
-0.4994
4
0
21
54.45
CC1=CN(C=N)C(C)=C1Cl
Cc1cn(C=N)c(C)c1Cl
false
CCC1CC(C)C(C)C1C
c1cc[nH]c1
156.616
43.0977
2.21351
2
1
19
28.78
CCNC(C)CS(N)(=O)=O
CCNC(C)CS(N)(=O)=O
true
CCCC(C)CC(C)(C)C
166.246
41.1129
-0.7271
3
2
24
72.19