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values | source_file stringclasses 6
values | raw stringlengths 237 2.81k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
NTR-001 | nootropics | compound | Piracetam | racetam | null | [
"AMPA receptor potentiation",
"Increased acetylcholine turnover",
"Membrane fluidity enhancement",
"Mitochondrial function improvement",
"NMDA receptor modulation"
] | [
"memory consolidation",
"verbal learning",
"cognitive processing speed",
"neuroprotection"
] | {"administration": ["oral"], "bioavailability_percent": 100, "frequency": "2-3x per day", "half_life_hours": 5, "high": "4800-9600mg/day", "onset_minutes": 30, "standard": "1600-4800mg/day"} | {"addiction_potential": "none", "contraindications": ["severe renal impairment", "hemorrhagic stroke"], "drug_interactions": ["potentiates stimulants", "anticoagulants (slight)"], "pregnancy": "avoid — insufficient data", "side_effects": ["headache (choline deficiency)", "brain fog at low choline", "insomnia if taken l... | moderate | nootropics/nootropics_database.json | {"cas_number": "7491-74-9", "category": "racetam", "choline_note": "Always stack with choline source (Alpha-GPC or CDP-choline) to prevent headaches and potentiate effects", "choline_requirement": "mandatory", "clinical_evidence": {"level": "moderate", "pubmed_ids": ["6135678", "9152205", "11139086"], "studies": ["Alzh... |
NTR-002 | nootropics | compound | Aniracetam | racetam | null | [
"AMPA receptor positive allosteric modulator",
"mGluR1/5 agonism",
"D2/D3 dopamine modulation",
"5-HT2A serotonin modulation",
"Acetylcholine release enhancement"
] | [
"anxiety reduction",
"holistic/creative thinking",
"mood enhancement",
"verbal fluency",
"memory"
] | {"administration": ["oral"], "bioavailability_percent": 15, "fat_soluble": true, "frequency": "2x per day", "half_life_hours": 1.5, "high": "1500-3000mg/day", "note": "MUST be taken with fat for absorption", "onset_minutes": 20, "standard": "750-1500mg/day"} | {"addiction_potential": "none", "contraindications": ["known hypersensitivity"], "drug_interactions": ["potentiates alcohol"], "side_effects": ["headache (choline deficiency)", "digestive upset", "irritability"], "tolerance": "low", "toxicity": "very low"} | moderate | nootropics/nootropics_database.json | {"cas_number": "72432-10-1", "category": "racetam", "choline_requirement": "recommended", "clinical_evidence": {"level": "moderate", "pubmed_ids": ["1794001", "11515981"], "studies": ["anxiety disorders", "ADHD adjunct", "cognitive aging", "stroke rehabilitation"]}, "cost_per_month_usd": 20, "dosing": {"administration"... |
NTR-003 | nootropics | compound | Alpha-GPC | cholinergic | null | [
"Direct acetylcholine precursor",
"Crosses blood-brain barrier efficiently",
"Growth hormone secretagogue (IV)",
"Neuroprotective via membrane phosphatidylcholine"
] | [
"focus",
"working memory",
"power output",
"racetam potentiation",
"GH pulse"
] | {"administration": ["oral", "IV (clinical)"], "bioavailability_percent": 40, "frequency": "1-2x per day", "half_life_hours": 4, "high": "600-1200mg/day", "onset_minutes": 45, "standard": "300-600mg/day"} | {"addiction_potential": "none", "contraindications": ["caution in bipolar disorder"], "drug_interactions": ["scopolamine antagonism", "anticholinergics"], "side_effects": ["headache at high doses", "depression (rare)", "fatigue", "GI upset"], "tolerance": "none", "toxicity": "very low"} | strong | nootropics/nootropics_database.json | {"cas_number": "28319-77-9", "category": "cholinergic", "clinical_evidence": {"level": "strong", "pubmed_ids": ["12637119", "10847474"], "studies": ["Alzheimer's disease", "stroke recovery", "age-related cognitive decline", "athletic performance"]}, "cost_per_month_usd": 25, "dosing": {"administration": ["oral", "IV (c... |
NTR-004 | nootropics | compound | Modafinil | eugeroic | null | [
"Dopamine reuptake inhibition (DAT)",
"Norepinephrine reuptake inhibition",
"Orexin/hypocretin system activation",
"Histamine H3 receptor antagonism",
"Glutamate enhancement, GABA reduction"
] | [
"wakefulness",
"executive function",
"working memory",
"motivation",
"fatigue resistance"
] | {"administration": ["oral"], "bioavailability_percent": 80, "frequency": "once per day (morning)", "half_life_hours": 12, "high": "200-400mg/day", "onset_minutes": 60, "standard": "100-200mg/day"} | {"addiction_potential": "low — much lower than traditional stimulants", "contraindications": ["hypersensitivity", "left ventricular hypertrophy", "Tourette syndrome"], "drug_interactions": ["CYP3A4 inducer — reduces hormonal contraceptives efficacy", "cyclosporine", "steroidal contraceptives"], "side_effects": ["insomn... | strong | nootropics/nootropics_database.json | {"cas_number": "68693-11-8", "category": "eugeroic", "clinical_evidence": {"level": "strong", "pubmed_ids": ["12190820", "11014561", "22736596"], "studies": ["narcolepsy (FDA approved)", "shift work disorder", "military cognitive performance", "ADHD adjunct"]}, "cost_per_month_usd": 30, "dosing": {"administration": ["o... |
NTR-005 | nootropics | compound | Lion's Mane (Hericium erinaceus) | natural | null | [
"NGF (Nerve Growth Factor) stimulation via hericenones",
"BDNF upregulation",
"Myelination support via erinacines (cross BBB)",
"Anti-neuroinflammation",
"Gut-brain axis modulation"
] | [
"neurogenesis",
"memory long-term",
"anxiety reduction",
"nerve regeneration",
"gut health"
] | {"administration": ["oral"], "form_note": "Fruiting body extract > mycelium. Look for >30% beta-glucans, confirmed erinacines content.", "frequency": "1-2x per day", "high": "1000-3000mg/day", "onset_days": 14, "peak_effect_weeks": 8, "standard": "500-1000mg/day"} | {"addiction_potential": "none", "contraindications": ["mushroom allergy", "autoimmune (theoretical — immunomodulatory)"], "drug_interactions": ["anticoagulants (theoretical)", "immunosuppressants (caution)"], "side_effects": ["GI discomfort (rare)", "allergy (mushroom sensitive)", "mild stimulation"], "tolerance": "non... | moderate (human) + strong (animal) | nootropics/nootropics_database.json | {"active_compounds": ["hericenones", "erinacines", "beta-glucans"], "cas_number": "N/A (mushroom extract)", "category": "natural", "clinical_evidence": {"level": "moderate (human) + strong (animal)", "pubmed_ids": ["18844328", "23735479", "31413172"], "studies": ["MCI improvement 2009 Mori", "anxiety/depression", "peri... |
NTR-006 | nootropics | compound | Bacopa Monnieri | adaptogen | null | [
"Protein kinase C activation in hippocampus",
"Dendrite branching enhancement",
"Acetylcholinesterase inhibition (mild)",
"MAO inhibition (mild)",
"Antioxidant — reduces lipid peroxidation",
"Cortisol modulation"
] | [
"memory consolidation",
"learning speed",
"anxiety reduction",
"neuroprotection"
] | {"administration": ["oral"], "fat_soluble": true, "frequency": "once per day with fat", "onset_weeks": 4, "peak_effect_weeks": 12, "standard": "300-450mg/day (45% bacosides)"} | {"addiction_potential": "none", "contraindications": ["thyroid disorders (may reduce T4)", "bradycardia"], "drug_interactions": ["thyroid medications", "sedatives (additive)", "CYP450 interactions"], "side_effects": ["nausea", "GI cramping", "dry mouth", "fatigue early on"], "tolerance": "none", "toxicity": "very low"} | strong — multiple RCTs | nootropics/nootropics_database.json | {"active_compounds": ["bacosides A & B", "bacopasaponins", "alkaloids"], "cas_number": "93164-91-1 (bacosides)", "category": "adaptogen", "clinical_evidence": {"level": "strong — multiple RCTs", "pubmed_ids": ["12093601", "22747190", "16401645"], "studies": ["memory in elderly (multiple)", "ADHD children", "anxiety", "... |
NTR-007 | nootropics | compound | Semax | peptide | null | [
"BDNF and NGF upregulation",
"Melanocortin receptor modulation (MC4R)",
"Dopamine and serotonin modulation",
"Anti-neuroinflammatory",
"Neuroprotection via oxidative stress reduction"
] | [
"executive function",
"working memory",
"motivation",
"ADHD symptoms",
"neuroprotection",
"stroke rehabilitation"
] | {"administration": ["intranasal (preferred)", "subcutaneous"], "cycle": "typically 2 weeks on, 2 weeks off", "frequency": "1-2x per day", "half_life_minutes": 20, "high": "600-900mcg/day", "onset_minutes": 15, "standard": "300-600mcg/day"} | {"addiction_potential": "low", "contraindications": ["mental health conditions (BDNF implications)", "epilepsy"], "drug_interactions": ["limited data"], "side_effects": ["nasal irritation", "mild anxiety at high doses", "fatigue post-cycle"], "tolerance": "mild with extended use", "toxicity": "very low"} | moderate (Russian clinical data) | nootropics/nootropics_database.json | {"cas_number": "80714-61-0", "category": "peptide", "clinical_evidence": {"level": "moderate (Russian clinical data)", "pubmed_ids": ["17017912", "11396316"], "studies": ["ADHD children (Russia)", "stroke recovery", "cognitive aging", "optic nerve disease"]}, "cost_per_month_usd": 40, "dosing": {"administration": ["int... |
NTR-008 | nootropics | compound | Noopept (Omberacetam) | racetam-like peptide | null | [
"NGF and BDNF expression upregulation",
"AMPA receptor sensitization",
"Acetylcholine potentiation",
"Alpha wave enhancement",
"Neuroprotection vs glutamate excitotoxicity"
] | [
"memory",
"learning",
"neuroprotection",
"mood",
"focus"
] | {"administration": ["oral", "sublingual (faster)", "intranasal"], "frequency": "2-3x per day", "half_life_minutes": 30, "high": "30-60mg/day", "onset_minutes": 15, "standard": "10-30mg/day"} | {"addiction_potential": "none", "contraindications": ["severe hepatic/renal impairment"], "side_effects": ["irritability", "brain fog (paradoxical)", "headache", "insomnia"], "tolerance": "low", "toxicity": "very low — 1000x more potent than piracetam by weight"} | moderate (primarily Russian/Eastern European) | nootropics/nootropics_database.json | {"cas_number": "157115-85-0", "category": "racetam-like peptide", "clinical_evidence": {"level": "moderate (primarily Russian/Eastern European)", "pubmed_ids": ["10977920"], "studies": ["cognitive impairment", "Alzheimer's adjunct", "anxiety-cognitive combo"]}, "cost_per_month_usd": 10, "dosing": {"administration": ["o... |
NTR-009 | nootropics | compound | Ashwagandha (KSM-66) | adaptogen | null | [
"HPA axis normalization",
"Cortisol reduction (11β-HSD1 inhibition)",
"GABA-A receptor modulation",
"Testosterone upregulation (LH potentiation)",
"Thyroid support (T3/T4 normalization)",
"Anti-inflammatory (NF-kB inhibition)"
] | [
"stress reduction",
"anxiety",
"testosterone",
"strength/recovery",
"thyroid function",
"sleep quality"
] | {"administration": ["oral"], "frequency": "1-2x per day", "high": "600-1200mg/day", "peak_effect_weeks": 8, "standard": "300-600mg/day (KSM-66 or Sensoril)"} | {"addiction_potential": "none", "contraindications": ["hyperthyroidism", "autoimmune (theoretical)", "pregnancy"], "drug_interactions": ["thyroid medications", "immunosuppressants", "sedatives"], "side_effects": ["GI upset", "drowsiness", "thyroid overstimulation"], "toxicity": "very low"} | strong | nootropics/nootropics_database.json | {"active_compounds": ["withanolides", "sitoindosides", "alkaloids"], "cas_number": "N/A", "category": "adaptogen", "clinical_evidence": {"level": "strong", "pubmed_ids": ["23439798", "25405876", "32242751"], "studies": ["cortisol reduction RCT", "testosterone increase", "strength performance", "anxiety", "thyroid funct... |
NTR-010 | nootropics | compound | Phenylpiracetam | racetam | null | [
"Dopamine receptor density upregulation",
"Norepinephrine potentiation",
"Acetylcholine enhancement",
"Alpha-adrenergic agonism",
"Psychomotor stimulation"
] | [
"stimulation",
"focus",
"physical performance",
"cold resistance",
"cognitive speed"
] | {"administration": ["oral"], "frequency": "max 2-3x per WEEK (rapid tolerance)", "half_life_hours": 5, "onset_minutes": 30, "standard": "100-200mg/dose"} | {"addiction_potential": "low", "contraindications": ["cardiovascular issues", "hypertension", "anxiety disorders"], "side_effects": ["insomnia", "irritability", "anxiety", "rapid tolerance"], "tolerance": "RAPID — use sparingly, max 2-3x/week", "toxicity": "low"} | moderate (Eastern European) | nootropics/nootropics_database.json | {"cas_number": "77472-70-9", "category": "racetam", "clinical_evidence": {"level": "moderate (Eastern European)", "studies": ["epilepsy adjunct", "stroke recovery", "cognitive impairment"]}, "cost_per_month_usd": 25, "dosing": {"administration": ["oral"], "frequency": "max 2-3x per WEEK (rapid tolerance)", "half_life_h... |
PEP-001 | peptides | compound | BPC-157 | null | null | [
"VEGF upregulation — promotes angiogenesis",
"eNOS pathway activation",
"Tendon fibroblast proliferation",
"FAK-paxillin pathway activation",
"Nitric oxide system modulation",
"Growth hormone receptor upregulation",
"Gut mucosal healing",
"Anti-inflammatory (NF-κB inhibition)"
] | [
"Tendon and ligament healing",
"Gut healing (IBD, leaky gut, ulcers)",
"Muscle healing post-injury",
"Joint repair",
"Neuroprotection",
"Systemic anti-inflammation"
] | {"administration": {"intramuscular": {"notes": "Faster local effect", "preferred_for": "localized muscle injury"}, "intranasal": {"notes": "Emerging use", "preferred_for": "neuroprotection, brain effects"}, "oral": {"notes": "Poor systemic bioavailability but locally active in GI tract", "preferred_for": "gut healing o... | {"cancer_concern": "theoretical due to angiogenesis promotion — not demonstrated in practice", "contraindications": ["active cancer (VEGF concern theoretical)", "pregnancy"], "drug_interactions": ["NSAIDs may reduce efficacy (competing pathways)", "anticoagulants"], "human_data": "limited formal trials — primarily rode... | null | peptides/peptides_database.json | {"amino_acids": 15, "cas_number": "137525-51-0", "dosing": {"administration": {"intramuscular": {"notes": "Faster local effect", "preferred_for": "localized muscle injury"}, "intranasal": {"notes": "Emerging use", "preferred_for": "neuroprotection, brain effects"}, "oral": {"notes": "Poor systemic bioavailability but l... |
PEP-002 | peptides | compound | TB-500 | null | null | [
"Actin sequestering — promotes cell migration",
"Stem cell differentiation support",
"Anti-inflammatory (down-regulates inflammatory cytokines)",
"Angiogenesis via Krüppel-like factor 2",
"Cardiac muscle protection",
"Blood vessel formation",
"Hair follicle stimulation"
] | [
"Systemic tissue repair",
"Chronic injury healing",
"Cardiovascular protection",
"Anti-fibrotic",
"Flexibility improvement",
"Wound healing",
"Hair regrowth"
] | {"administration": ["subcutaneous", "intramuscular"], "loading_phase": {"dose_mg": 5, "duration_weeks": 4, "frequency": "twice weekly", "note": "Loading phase builds tissue levels"}, "maintenance_phase": {"dose_mg": 2.5, "duration_weeks": "ongoing", "frequency": "twice weekly"}} | {"contraindications": ["active cancer", "pregnancy"], "human_data": "Phase I/II trials (cardiac repair) — generally well tolerated", "side_effects": ["injection site pain", "head rush (brief)", "fatigue", "nausea (rare)"], "toxicity": "low"} | null | peptides/peptides_database.json | {"cas_number": "77591-33-4", "dosing": {"administration": ["subcutaneous", "intramuscular"], "loading_phase": {"dose_mg": 5, "duration_weeks": 4, "frequency": "twice weekly", "note": "Loading phase builds tissue levels"}, "maintenance_phase": {"dose_mg": 2.5, "duration_weeks": "ongoing", "frequency": "twice weekly"}}, ... |
PEP-003 | peptides | compound | Ipamorelin | GHRP (Growth Hormone Releasing Peptide) | null | [
"Selective GHS-R1a agonist",
"Pulsatile GH release from pituitary",
"Ghrelin receptor activation",
"No cortisol or prolactin increase (unlike other GHRPs)"
] | [
"GH pulse stimulation",
"fat loss",
"muscle preservation",
"sleep quality",
"recovery"
] | {"administration": ["subcutaneous", "intramuscular"], "cycle": "12 weeks on, 4 weeks off", "frequency": "2-3x per day", "optimal_timing": ["fasted — AM", "pre-workout", "before bed (strongest GH pulse during sleep)"], "range_mcg": "100-300", "standard_mcg": 200} | {"contraindications": ["active cancer", "pregnancy", "acromegaly"], "drug_interactions": ["insulin — timing", "glucocorticoids reduce effect"], "side_effects": ["water retention", "mild hunger", "tingling/numbness (carpal tunnel at high GH)", "cortisol (minimal)"], "toxicity": "low"} | null | peptides/peptides_database.json | {"cas_number": "170851-70-4", "category": "GHRP (Growth Hormone Releasing Peptide)", "dosing": {"administration": ["subcutaneous", "intramuscular"], "cycle": "12 weeks on, 4 weeks off", "frequency": "2-3x per day", "optimal_timing": ["fasted — AM", "pre-workout", "before bed (strongest GH pulse during sleep)"], "range_... |
PEP-004 | peptides | compound | CJC-1295 (with DAC) | GHRH analogue | null | [
"GHRH receptor agonism",
"Sustained GH secretion via DAC (half-life extension)",
"IGF-1 upregulation",
"Pituitary sensitization to GHRP"
] | [
"sustained GH elevation",
"IGF-1 increase",
"muscle growth",
"fat loss",
"recovery",
"anti-aging"
] | {"administration": ["subcutaneous"], "frequency": "1-2x per week (due to long half-life from DAC)", "half_life_days": 6, "note": "CJC-1295 without DAC = Mod GRF 1-29 — very different dosing (2-3x/day)", "standard_mcg": 1000} | {"contraindications": ["active cancer", "diabetes", "acromegaly", "pregnancy"], "side_effects": ["water retention", "joint pain (GH related)", "fatigue", "hypoglycemia (rare)"]} | null | peptides/peptides_database.json | {"category": "GHRH analogue", "dosing": {"administration": ["subcutaneous"], "frequency": "1-2x per week (due to long half-life from DAC)", "half_life_days": 6, "note": "CJC-1295 without DAC = Mod GRF 1-29 — very different dosing (2-3x/day)", "standard_mcg": 1000}, "full_name": "Drug Affinity Complex Growth Hormone Rel... |
PEP-005 | peptides | compound | Selank | anxiolytic peptide | null | [
"Enkephalinase inhibition (endorphin preservation)",
"BDNF upregulation",
"IL-6 modulation",
"GABAergic modulation (non-benzodiazepine)",
"Dopamine, serotonin, norepinephrine balance"
] | [
"anxiety elimination",
"cognitive clarity",
"stress resilience",
"mood stabilization",
"memory"
] | {"administration": ["intranasal (preferred)", "subcutaneous"], "cycle": "2-4 weeks continuous, then break", "frequency": "1-2x per day", "range_mcg": "250-1000", "standard_mcg": 250} | {"addiction_potential": "none — unlike benzodiazepines", "contraindications": [], "side_effects": ["mild sedation", "nasal irritation (intranasal)"], "toxicity": "very low"} | null | peptides/peptides_database.json | {"cas_number": "129954-34-3", "category": "anxiolytic peptide", "dosing": {"administration": ["intranasal (preferred)", "subcutaneous"], "cycle": "2-4 weeks continuous, then break", "frequency": "1-2x per day", "range_mcg": "250-1000", "standard_mcg": 250}, "id": "PEP-005", "mechanisms": ["Enkephalinase inhibition (end... |
PEP-006 | peptides | compound | GHK-Cu (Copper Peptide) | null | null | [
"Copper delivery to tissues",
"Collagen and elastin synthesis",
"Superoxide dismutase activation",
"Anti-inflammatory gene activation (>4000 genes modulated)",
"Stem cell activation",
"DNA repair enhancement",
"Anti-fibrotic"
] | [
"skin repair and anti-aging",
"wound healing",
"hair regrowth",
"anti-inflammation",
"systemic repair"
] | {"subcutaneous": {"dose_mg": "0.5-2", "frequency": "daily to 3x/week", "notes": "Systemic anti-aging use"}, "topical": {"application": "affected area", "concentration_percent": "0.1-1", "frequency": "1-2x per day"}} | {"notes": "One of the safest peptides — naturally occurring, declining with age", "side_effects": ["copper excess at very high doses (theoretical)"], "toxicity": "very low — endogenous compound"} | strong for topical, moderate for systemic | peptides/peptides_database.json | {"cas_number": "49557-75-7", "dosing": {"subcutaneous": {"dose_mg": "0.5-2", "frequency": "daily to 3x/week", "notes": "Systemic anti-aging use"}, "topical": {"application": "affected area", "concentration_percent": "0.1-1", "frequency": "1-2x per day"}}, "evidence": {"level": "strong for topical, moderate for systemic... |
PEP-007 | peptides | compound | Epithalon (Epitalon) | null | null | [
"Telomerase activation (hTERT upregulation)",
"Pineal gland stimulation → melatonin normalization",
"Antioxidant gene activation",
"Tumor suppressor gene activation",
"Circadian rhythm restoration"
] | [
"telomere lengthening",
"longevity",
"sleep normalization",
"anti-cancer (reported)",
"immune optimization"
] | {"course_protocol": {"administration": ["subcutaneous", "intramuscular", "intranasal"], "dose_mg": 5, "duration_days": 10, "frequency": "once daily", "frequency_of_courses": "1-2 per year"}} | {"contraindications": ["active cancer (theoretical — telomerase)"], "side_effects": ["injection site reaction", "vivid dreams (melatonin effect)"], "toxicity": "very low"} | moderate — Khavinson Institute data (Russia) | peptides/peptides_database.json | {"cas_number": "307297-39-8", "dosing": {"course_protocol": {"administration": ["subcutaneous", "intramuscular", "intranasal"], "dose_mg": 5, "duration_days": 10, "frequency": "once daily", "frequency_of_courses": "1-2 per year"}}, "evidence": {"animal_studies": "life extension in mice 25%", "human_studies": "limited f... |
LON-001 | longevity | compound | Rapamycin (Sirolimus) | mTOR inhibitor | null | [
"mTORC1 inhibition via FKBP12 complex",
"Autophagy induction",
"Senescent cell burden reduction",
"Immune system rejuvenation",
"Translation regulation"
] | [] | {"aggressive": {"dose_mg": "2-5", "frequency": "daily", "note": "Classical transplant-derived approach, higher side effect risk"}, "alan_green_protocol": {"dose_mg": 6, "frequency": "weekly", "note": "Popular longevity physician protocol"}, "intermittent_biohacking": {"dose_mg": "5-10", "frequency": "once weekly", "rat... | {"contraindications": ["active infection", "immunocompromised baseline", "pregnancy"], "drug_interactions": ["CYP3A4 substrate — grapefruit, many drugs"], "monitoring": ["lipids", "glucose", "CBC", "infection status"], "side_effects_chronic_high_dose": ["immunosuppression", "insulin resistance", "hyperlipidemia", "mout... | null | longevity/longevity_database.json | {"cas_number": "53123-88-9", "category": "mTOR inhibitor", "dosing_protocols": {"aggressive": {"dose_mg": "2-5", "frequency": "daily", "note": "Classical transplant-derived approach, higher side effect risk"}, "alan_green_protocol": {"dose_mg": 6, "frequency": "weekly", "note": "Popular longevity physician protocol"}, ... |
LON-002 | longevity | compound | Metformin | AMPK activator / biguanide | null | [
"Complex I mitochondrial inhibition → AMPK activation",
"mTORC1 inhibition (indirect via AMPK)",
"FOXO3a activation",
"Mitohormesis induction",
"microRNA-21 modulation",
"Gut microbiome modulation",
"Anti-inflammatory (NF-κB inhibition)"
] | [] | {"extended_release": {"form": "Metformin XR", "note": "Better GI tolerability, same efficacy"}, "standard_longevity": {"dose_mg": "500-1000", "frequency": "1-2x daily with meals", "titration": "start 500mg, increase slowly to reduce GI side effects"}} | {"contraindications": ["eGFR <30", "hepatic failure", "IV contrast (hold 48h)", "alcoholism"], "exercise_concern": "may blunt mitochondrial adaptations from exercise — consider timing", "monitoring": ["B12 annually", "creatinine/eGFR", "CBC"], "side_effects": ["GI upset (nausea, diarrhea) — dose-dependent", "B12 defici... | null | longevity/longevity_database.json | {"cas_number": "657-24-9", "category": "AMPK activator / biguanide", "dosing_protocols": {"extended_release": {"form": "Metformin XR", "note": "Better GI tolerability, same efficacy"}, "standard_longevity": {"dose_mg": "500-1000", "frequency": "1-2x daily with meals", "titration": "start 500mg, increase slowly to reduc... |
LON-003 | longevity | compound | NMN (Nicotinamide Mononucleotide) | NAD+ precursor | null | [
"Direct NAD+ precursor (bypasses rate-limiting NAMPT)",
"Sirtuin (SIRT1-7) activation via NAD+",
"PARP activation for DNA repair",
"CD38 substrates — immune function",
"Mitochondrial biogenesis (PGC-1α)",
"Circadian clock regulation"
] | [] | {"high_dose": {"dose_mg": "1000-2000", "note": "Sinclair protocol range"}, "standard": {"dose_mg": 500, "form": "sublingual or enteric-coated preferred", "frequency": "once daily (morning)"}} | {"concern": "NAD+ feeds cancer cell metabolism (theoretical — not demonstrated as harmful in humans)", "monitoring": "none required for standard doses", "side_effects": ["nausea at high doses", "flushing (less than niacin)", "GI upset"], "toxicity": "very low"} | null | longevity/longevity_database.json | {"cas_number": "1094-61-7", "category": "NAD+ precursor", "dosing_protocols": {"high_dose": {"dose_mg": "1000-2000", "note": "Sinclair protocol range"}, "standard": {"dose_mg": 500, "form": "sublingual or enteric-coated preferred", "frequency": "once daily (morning)"}}, "evidence": {"animal": "strong — multiple lifespa... |
LON-004 | longevity | compound | Fisetin | senolytic flavonoid | null | [
"Senescent cell elimination (apoptosis induction)",
"BCL-2/BCL-XL inhibition in senescent cells",
"PI3K/Akt pathway inhibition",
"mTOR inhibition",
"Anti-inflammatory (NF-κB, AP-1 inhibition)",
"Nrf2 activation — antioxidant response",
"Sirtuin activation"
] | [] | {"daily_maintenance": {"dose_mg": "100-500", "frequency": "daily with fat"}, "senolytic_pulse": {"dose_mg": "1000-1500", "note": "Mayo Clinic inspired protocol", "protocol": "2 consecutive days per month", "rationale": "senolytic effect — intermittent high dose clears senescent cells"}} | {"bioavailability_note": "poor oral bioavailability — take with fat, consider liposomal form", "side_effects": ["GI upset at high doses"], "toxicity": "very low"} | null | longevity/longevity_database.json | {"cas_number": "528-48-3", "category": "senolytic flavonoid", "dosing_protocols": {"daily_maintenance": {"dose_mg": "100-500", "frequency": "daily with fat"}, "senolytic_pulse": {"dose_mg": "1000-1500", "note": "Mayo Clinic inspired protocol", "protocol": "2 consecutive days per month", "rationale": "senolytic effect —... |
LON-005 | longevity | compound | Quercetin | senolytic / anti-inflammatory flavonoid | null | [
"Senolytic (BCL-2 family inhibition — weaker than dasatinib)",
"PI3K inhibition",
"Zinc ionophore (with zinc — antiviral)",
"Anti-inflammatory (histamine, NF-κB)",
"AMPK activation",
"Autophagy promotion"
] | [] | {"daily_supplement": {"dose_mg": "500-1000", "form": "quercetin phytosome (better bioavailability)"}, "senolytic_combo": {"compound_combo": "Quercetin 1000mg + Dasatinib 100mg (prescription)", "evidence": "Mayo Clinic human trial in IPF", "protocol": "2 consecutive days, quarterly"}} | {"drug_interactions": ["CYP3A4 inhibitor", "quinolone antibiotics (spacing required)", "blood thinners"], "side_effects": ["GI upset", "headache at high doses"]} | null | longevity/longevity_database.json | {"cas_number": "117-39-5", "category": "senolytic / anti-inflammatory flavonoid", "dosing_protocols": {"daily_supplement": {"dose_mg": "500-1000", "form": "quercetin phytosome (better bioavailability)"}, "senolytic_combo": {"compound_combo": "Quercetin 1000mg + Dasatinib 100mg (prescription)", "evidence": "Mayo Clinic ... |
LON-006 | longevity | compound | Spermidine | autophagy inducer / polyamine | null | [
"Autophagy induction (TFEB activation)",
"Epigenetic — histone deacetylation inhibition",
"Anti-inflammatory",
"Mitochondrial membrane potential restoration",
"Cardioprotective"
] | [] | {"note": "wheat germ is most concentrated natural source", "standard_mg": "1-5 from wheat germ extract"} | {"side_effects": ["GI effects at high doses"], "toxicity": "very low — endogenous compound declining with age"} | null | longevity/longevity_database.json | {"cas_number": "124-20-9", "category": "autophagy inducer / polyamine", "dosing": {"note": "wheat germ is most concentrated natural source", "standard_mg": "1-5 from wheat germ extract"}, "found_in": ["wheat germ (highest)", "soybeans", "mushrooms", "peas", "blue cheese"], "id": "LON-006", "longevity_evidence": {"anima... |
LON-007 | longevity | compound | Alpha-Ketoglutarate (AKG) | TCA cycle intermediate | null | [
"TCA cycle substrate — mitochondrial energy",
"Prolyl hydroxylase substrate → HIF-1α regulation",
"Epigenetic regulation via α-KG dependent dioxygenases (TET, JHDM)",
"Anti-inflammatory",
"Collagen synthesis support (prolyl hydroxylase)",
"mTOR inhibition (modest)"
] | [] | {"form": "CaAKG preferred", "frequency": "daily", "standard_mg": "1000-3000"} | {"side_effects": ["GI upset at high doses"], "toxicity": "very low — endogenous metabolite"} | null | longevity/longevity_database.json | {"cas_number": "328-50-7", "category": "TCA cycle intermediate", "dosing": {"form": "CaAKG preferred", "frequency": "daily", "standard_mg": "1000-3000"}, "forms": ["Calcium AKG (CaAKG)", "Arginine AKG"], "id": "LON-007", "longevity_evidence": {"biomarker_trial": "human trial on methylation clocks", "mouse_study": "Maks... |
LON-008 | longevity | compound | Urolithin A | mitophagy inducer | null | [
"Mitophagy induction (selective autophagy of damaged mitochondria)",
"Mitochondrial biogenesis",
"NF-κB inhibition",
"AMPK activation",
"Muscle function improvement"
] | [] | {"form": "Mitopure (Amazentis) — standardized urolithin A", "frequency": "daily", "note": "Only ~40% of people have gut bacteria to produce from food — supplement bypasses this", "standard_mg": "500-1000"} | {"side_effects": ["mild GI effects"], "toxicity": "very low"} | null | longevity/longevity_database.json | {"cas_number": "1143-70-0", "category": "mitophagy inducer", "dosing": {"form": "Mitopure (Amazentis) — standardized urolithin A", "frequency": "daily", "note": "Only ~40% of people have gut bacteria to produce from food — supplement bypasses this", "standard_mg": "500-1000"}, "id": "LON-008", "longevity_evidence": {"h... |
BM-H001 | biomarkers | biomarker | Testosterone (Total) | hormones | null | [] | [] | null | gynecomastia | fatigue | low libido | loss of muscle mass | depression | null | biomarkers/biomarkers_database.json | {"frequency": "every 3-6 months", "high_concern_above": 1100, "id": "BM-H001", "key_interactions": ["SHBG affects free testosterone", "LH indicates cause of low T", "E2 balance critical"], "low_concern_below": 400, "name": "Testosterone (Total)", "natural_optimization": ["resistance training — compound lifts", "sleep 7... |
BM-H002 | biomarkers | biomarker | Free Testosterone | hormones | More actionable than total T — bioavailable fraction | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"high_shbg_interventions": ["nettle root extract", "optimize insulin sensitivity"], "id": "BM-H002", "low_shbg_interventions": ["boron 10mg/day reduces SHBG", "weight loss", "avoid excess alcohol"], "name": "Free Testosterone", "note": "More actionable than total T — bioavailable fraction", "optimal_biohacker_range": ... |
BM-H003 | biomarkers | biomarker | Estradiol (E2) | hormones | Too low is as bad as too high for males. Critical for bone, libido, cardiovascular. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"high_e2_signs": ["water retention", "gynecomastia", "mood issues", "fatigue"], "id": "BM-H003", "low_e2_signs": ["joint pain", "low libido", "brain fog", "poor bone density"], "name": "Estradiol (E2)", "natural_optimization": ["DIM (diindolylmethane) 200mg — shifts 2-OH pathway", "calcium D-glucarate", "body fat redu... |
BM-H004 | biomarkers | biomarker | IGF-1 | hormones | TENSION: higher IGF-1 = muscle/performance; lower = longevity (mTOR/cancer). Context matters. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"id": "BM-H004", "influences": ["GH pulsatility", "sleep quality", "protein intake", "insulin sensitivity", "liver health"], "name": "IGF-1", "natural_optimization": ["optimize sleep — deep sleep GH pulse", "GHRP peptides (research)", "resistance training", "adequate protein 1.6-2.2g/kg"], "note": "TENSION: higher IGF... |
BM-H005 | biomarkers | biomarker | Cortisol (AM) | hormones | null | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"chronic_high_effects": ["muscle catabolism", "insulin resistance", "hippocampal shrinkage", "immune suppression", "T3 conversion inhibition"], "id": "BM-H005", "name": "Cortisol (AM)", "optimal_biohacker_range": "10-18", "optimization": ["ashwagandha (strongest evidence)", "rhodiola rosea", "phosphatidylserine 400mg"... |
BM-H006 | biomarkers | biomarker | TSH (Thyroid Stimulating Hormone) | hormones | Standard range too wide. Optimal is lower end. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"complementary_tests": ["Free T4", "Free T3", "Reverse T3", "TPO antibodies", "thyroglobulin antibodies"], "id": "BM-H006", "low_thyroid_signs": ["fatigue", "cold intolerance", "weight gain", "brain fog", "hair loss", "constipation"], "name": "TSH (Thyroid Stimulating Hormone)", "note": "Standard range too wide. Optim... |
BM-M001 | biomarkers | biomarker | Fasting Glucose | metabolic | Even 'normal' range upper end associates with increased risk. Optimal is lower. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"id": "BM-M001", "name": "Fasting Glucose", "note": "Even 'normal' range upper end associates with increased risk. Optimal is lower.", "optimal_biohacker_range": "72-85", "optimization": ["time-restricted eating (16:8)", "berberine 500mg 3x/day (comparable to metformin)", "metformin 500-1000mg (prescription)", "resist... |
BM-M002 | biomarkers | biomarker | HbA1c | metabolic | 3-month average glucose. Best single metabolic marker for longevity. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"id": "BM-M002", "name": "HbA1c", "note": "3-month average glucose. Best single metabolic marker for longevity.", "optimal_biohacker_range": "4.8-5.3", "optimization": ["same as fasting glucose interventions", "CGM monitoring for personalized response"], "standard_lab_normal": "<5.7", "unit": "%"} |
BM-M003 | biomarkers | biomarker | Insulin (fasting) | metabolic | Most labs don't flag until >25. Optimal is <6. Hyperinsulinemia is silent. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"high_insulin_effects": ["promotes fat storage", "mTOR activation", "accelerated aging", "cancer promotion", "cardiovascular risk"], "id": "BM-M003", "name": "Insulin (fasting)", "note": "Most labs don't flag until >25. Optimal is <6. Hyperinsulinemia is silent.", "optimal_biohacker_range": "2-6", "optimization": ["ti... |
BM-M004 | biomarkers | biomarker | ApoB | metabolic | Best cardiovascular risk predictor — counts all atherogenic particles. Superior to LDL-C alone. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"id": "BM-M004", "longevity_target": "<60", "name": "ApoB", "note": "Best cardiovascular risk predictor — counts all atherogenic particles. Superior to LDL-C alone.", "optimal_biohacker_range": "<80", "optimization": ["statins (if indicated)", "pcsk9 inhibitors (aggressive)", "low-saturated fat diet", "omega-3 high do... |
BM-M005 | biomarkers | biomarker | hsCRP (high-sensitivity C-reactive protein) | metabolic | Key inflammaging marker. Even mildly elevated CRP predicts all-cause mortality. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"causes_of_elevation": ["metabolic syndrome", "gut dysbiosis", "sleep apnea", "dental disease", "food sensitivities", "hidden infection"], "id": "BM-M005", "name": "hsCRP (high-sensitivity C-reactive protein)", "note": "Key inflammaging marker. Even mildly elevated CRP predicts all-cause mortality.", "optimal_biohacke... |
BM-M006 | biomarkers | biomarker | Homocysteine | metabolic | Cardiovascular + Alzheimer's risk marker. Very modifiable. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"high_causes": ["MTHFR polymorphism", "B12 deficiency", "folate deficiency", "B6 deficiency", "renal impairment", "hypothyroidism"], "id": "BM-M006", "name": "Homocysteine", "note": "Cardiovascular + Alzheimer's risk marker. Very modifiable.", "optimal_biohacker_range": "6-9", "optimization": ["methylfolate (5-MTHF) 4... |
BM-N001 | biomarkers | biomarker | Vitamin D (25-OH) | micronutrients | K2 routes calcium to bones not arteries. Magnesium required for D3 activation. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"cofactors_required": ["Vitamin K2 (MK-7) 200mcg", "Magnesium 400mg"], "id": "BM-N001", "name": "Vitamin D (25-OH)", "note": "K2 routes calcium to bones not arteries. Magnesium required for D3 activation.", "optimal_biohacker_range": "60-80", "optimization_dose": {"deficient_below30": "5000-10000 IU/day for 3 months, ... |
BM-N002 | biomarkers | biomarker | Magnesium (RBC) | micronutrients | RBC magnesium is far superior to serum — reflects intracellular stores | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"deficiency_prevalence": "~45% of population subclinically deficient", "dose_mg": "300-500 elemental", "effects_of_deficiency": ["poor sleep", "muscle cramps", "anxiety", "insulin resistance", "hypertension", "migraines"], "forms_and_uses": {"L-threonate": "brain penetrating — cognitive", "citrate": "constipation, gen... |
BM-N003 | biomarkers | biomarker | Ferritin | micronutrients | Very low = iron deficiency (energy/cognitive). Very high = oxidative stress, hemochromatosis. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"high_ferritin_concern_above": 200, "id": "BM-N003", "low_concern_below": 30, "name": "Ferritin", "note": "Very low = iron deficiency (energy/cognitive). Very high = oxidative stress, hemochromatosis.", "optimal_biohacker_range": "50-150", "optimization_high": ["blood donation — most effective", "IP6 (inositol hexapho... |
BM-N004 | biomarkers | biomarker | Omega-3 Index | micronutrients | null | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"average_US_population": "~4-5%", "evidence": "among strongest supplements for cardiovascular, brain, inflammation", "id": "BM-N004", "name": "Omega-3 Index", "optimal_biohacker_range": "10-12%", "optimization": {"dose_grams_EPA_DHA": "3-4", "form": "triglyceride form > ethyl ester", "time_to_optimal_months": 3, "with... |
BM-A001 | biomarkers | biomarker | Epigenetic Age (Horvath Clock / DunedinPACE) | aging_clocks | null | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"actionable": true, "cost_usd": "200-400", "frequency": "yearly", "id": "BM-A001", "interventions_shown_to_reduce": ["exercise (aerobic + resistance)", "dietary restriction / caloric restriction", "rapamycin", "NMN/NR", "DHEA", "alpha-ketoglutarate (Conboy trial)", "plasma exchange (experimental)"], "name": "Epigeneti... |
BM-A002 | biomarkers | biomarker | Telomere Length | aging_clocks | Controversial — high variability between tests. DunedinPACE more actionable. | [] | [] | null | null | null | biomarkers/biomarkers_database.json | {"id": "BM-A002", "interventions": ["exercise", "stress reduction", "cycloastragenol (TA-65)", "epithalon peptide"], "name": "Telomere Length", "note": "Controversial — high variability between tests. DunedinPACE more actionable.", "providers": ["LifeLength", "TeloYears"], "type": "telomere length measurement", "what_i... |
PROT-001 | protocols | protocol | Morning Cognitive Stack | beginner | Peak mental performance, executive function, sustained focus | [] | [] | {"compounds": [{"compound": "Modafinil", "dose": "100mg", "note": "for high-demand days", "optional": true, "timing": "with breakfast"}, {"compound": "Alpha-GPC", "dose": "300mg", "timing": "AM"}, {"compound": "Lion's Mane extract", "dose": "1000mg", "timing": "AM"}, {"compound": "Bacopa Monnieri", "dose": "300mg", "ti... | null | null | protocols/protocols_database.json | {"compounds": [{"compound": "Modafinil", "dose": "100mg", "note": "for high-demand days", "optional": true, "timing": "with breakfast"}, {"compound": "Alpha-GPC", "dose": "300mg", "timing": "AM"}, {"compound": "Lion's Mane extract", "dose": "1000mg", "timing": "AM"}, {"compound": "Bacopa Monnieri", "dose": "300mg", "ti... |
PROT-002 | protocols | protocol | Injury Healing Protocol | intermediate | Accelerate healing of tendons, ligaments, muscles, gut | [] | [] | {"compounds": [{"compound": "BPC-157", "dose": "250-500mcg", "phase": "acute + maintenance", "timing": "2x daily SC near injury"}, {"compound": "TB-500", "dose": "5mg", "phase": "loading (4 weeks)", "timing": "2x weekly SC"}, {"compound": "TB-500", "dose": "2.5mg", "phase": "maintenance", "timing": "2x weekly SC"}, {"c... | null | null | protocols/protocols_database.json | {"compounds": [{"compound": "BPC-157", "dose": "250-500mcg", "phase": "acute + maintenance", "timing": "2x daily SC near injury"}, {"compound": "TB-500", "dose": "5mg", "phase": "loading (4 weeks)", "timing": "2x weekly SC"}, {"compound": "TB-500", "dose": "2.5mg", "phase": "maintenance", "timing": "2x weekly SC"}, {"c... |
PROT-003 | protocols | protocol | Testosterone Optimization (Natural) | beginner | Maximize endogenous testosterone production without exogenous hormones | [] | [] | {"compounds": [{"compound": "Ashwagandha KSM-66", "dose": "600mg", "timing": "evening with food"}, {"compound": "Zinc", "dose": "30mg bisglycinate", "timing": "evening"}, {"compound": "Magnesium glycinate", "dose": "400mg", "timing": "before bed"}, {"compound": "Vitamin D3", "dose": "5000IU", "timing": "morning with K2... | null | null | protocols/protocols_database.json | {"compounds": [{"compound": "Ashwagandha KSM-66", "dose": "600mg", "timing": "evening with food"}, {"compound": "Zinc", "dose": "30mg bisglycinate", "timing": "evening"}, {"compound": "Magnesium glycinate", "dose": "400mg", "timing": "before bed"}, {"compound": "Vitamin D3", "dose": "5000IU", "timing": "morning with K2... |
PROT-004 | protocols | protocol | Longevity Core Stack (Bryan Johnson inspired) | advanced | Comprehensive hallmarks of aging coverage for healthspan extension | [] | [] | {"compounds": [], "daily_compounds": [{"compound": "NMN", "dose": "500-1000mg", "timing": "morning sublingual"}, {"compound": "Resveratrol", "dose": "1000mg", "timing": "morning with fat (Sinclair protocol)"}, {"compound": "TMG (Trimethylglycine)", "dose": "1000mg", "note": "methyl donor", "timing": "morning"}, {"compo... | null | null | protocols/protocols_database.json | {"cost_per_month_usd_supplements": 300, "daily_compounds": [{"compound": "NMN", "dose": "500-1000mg", "timing": "morning sublingual"}, {"compound": "Resveratrol", "dose": "1000mg", "timing": "morning with fat (Sinclair protocol)"}, {"compound": "TMG (Trimethylglycine)", "dose": "1000mg", "note": "methyl donor", "timing... |
PROT-005 | protocols | protocol | GH Optimization Stack | advanced | Maximize endogenous GH pulsatility, IGF-1, body composition | [] | [] | {"compounds": [{"compound": "CJC-1295 (with DAC)", "dose": "1000mcg", "note": "GHRH analogue", "timing": "2x weekly SC"}, {"compound": "Ipamorelin", "dose": "300mcg", "note": "GHRP — cleanest", "timing": "3x daily SC — AM, pre-workout, before bed"}, {"compound": "MK-677 (Ibutamoren)", "dose": "12.5-25mg", "note": "oral... | null | null | protocols/protocols_database.json | {"compounds": [{"compound": "CJC-1295 (with DAC)", "dose": "1000mcg", "note": "GHRH analogue", "timing": "2x weekly SC"}, {"compound": "Ipamorelin", "dose": "300mcg", "note": "GHRP — cleanest", "timing": "3x daily SC — AM, pre-workout, before bed"}, {"compound": "MK-677 (Ibutamoren)", "dose": "12.5-25mg", "note": "oral... |
PROT-006 | protocols | protocol | Sleep & Recovery Protocol | beginner | Deep sleep optimization, HRV improvement, overnight recovery | [] | [] | {"compounds": [{"compound": "Magnesium glycinate", "dose": "400mg", "timing": "1h before bed"}, {"compound": "Glycine", "dose": "3g", "note": "reduces core body temp, improves deep sleep", "timing": "30min before bed"}, {"compound": "L-theanine", "dose": "200mg", "timing": "30min before bed"}, {"compound": "Ashwagandha... | null | null | protocols/protocols_database.json | {"compounds": [{"compound": "Magnesium glycinate", "dose": "400mg", "timing": "1h before bed"}, {"compound": "Glycine", "dose": "3g", "note": "reduces core body temp, improves deep sleep", "timing": "30min before bed"}, {"compound": "L-theanine", "dose": "200mg", "timing": "30min before bed"}, {"compound": "Ashwagandha... |
NUT-001 | nutrition | dietary_strategy | Time-Restricted Eating (TRE) | dietary_strategy | Autophagy induction (16h+ fasting) | Insulin sensitivity improvement | mTOR suppression during fast | Circadian rhythm alignment | Weight management | Reduced inflammation | [] | [
"Autophagy induction (16h+ fasting)",
"Insulin sensitivity improvement",
"mTOR suppression during fast",
"Circadian rhythm alignment",
"Weight management",
"Reduced inflammation"
] | [{"difficulty": "easy", "eating_window_hours": 8, "evidence": "strong", "fast_hours": 16, "name": "16:8"}, {"difficulty": "moderate", "eating_window_hours": 6, "evidence": "strong", "fast_hours": 18, "name": "18:6"}, {"difficulty": "hard", "eating_window_hours": 1, "evidence": "moderate", "fast_hours": 23, "name": "OMA... | null | null | nutrition/nutrition_database.json | {"autophagy_threshold_hours": 16, "benefits": ["Autophagy induction (16h+ fasting)", "Insulin sensitivity improvement", "mTOR suppression during fast", "Circadian rhythm alignment", "Weight management", "Reduced inflammation"], "id": "NUT-001", "key_rules": ["Coffee/tea (no calories) allowed in fast", "Break fast with ... |
NUT-002 | nutrition | dietary_strategy | Protein Optimization | dietary_strategy | null | [] | [] | {"leucine_threshold_g_per_meal": 2.5, "max_beneficial_g_per_kg": 2.2, "meal_frequency_for_mps": "3-4 meals with 30-40g protein each", "minimum_muscle_preservation_g_per_kg": 1.6, "optimal_muscle_building_g_per_kg": 2.0} | null | null | nutrition/nutrition_database.json | {"id": "NUT-002", "name": "Protein Optimization", "sources_ranked": [{"digestibility_DIAAS": 1.25, "leucine_percent": 11, "notes": "fastest absorption, highest leucine", "source": "Whey isolate"}, {"digestibility_DIAAS": 1.22, "leucine_percent": 9, "notes": "slow release, ideal pre-bed", "source": "Casein"}, {"digestib... |
NUT-003 | nutrition | dietary_strategy | Ketogenic Diet for Performance & Cognition | dietary_strategy | Ketone bodies (BHB) — cleaner brain fuel | Reduced neuroinflammation | Metabolic flexibility | Appetite suppression (ghrelin reduction) | mTOR pulsatility vs chronic activation | [] | [
"Ketone bodies (BHB) — cleaner brain fuel",
"Reduced neuroinflammation",
"Metabolic flexibility",
"Appetite suppression (ghrelin reduction)",
"mTOR pulsatility vs chronic activation"
] | {} | null | null | nutrition/nutrition_database.json | {"adaptation_period_weeks": "2-6 (keto flu during transition)", "benefits": ["Ketone bodies (BHB) — cleaner brain fuel", "Reduced neuroinflammation", "Metabolic flexibility", "Appetite suppression (ghrelin reduction)", "mTOR pulsatility vs chronic activation"], "carb_threshold_g": 20, "exogenous_ketones": {"limitation"... |
NUT-MICRO-omega-3-(epa/dha) | nutrition | micronutrient | Omega-3 (EPA/DHA) | micronutrient | anti-inflammatory | cardiovascular | brain structure | insulin sensitivity | cortisol reduction | [] | [
"anti-inflammatory",
"cardiovascular",
"brain structure",
"insulin sensitivity",
"cortisol reduction"
] | {"benefits": ["anti-inflammatory", "cardiovascular", "brain structure", "insulin sensitivity", "cortisol reduction"], "best_sources": ["sardines", "mackerel", "wild salmon", "anchovies", "fish oil triglyceride form"], "nutrient": "Omega-3 (EPA/DHA)", "omega3_index_target_percent": "10-12", "optimal_intake_g_EPA_DHA": "... | null | null | nutrition/nutrition_database.json | {"benefits": ["anti-inflammatory", "cardiovascular", "brain structure", "insulin sensitivity", "cortisol reduction"], "best_sources": ["sardines", "mackerel", "wild salmon", "anchovies", "fish oil triglyceride form"], "nutrient": "Omega-3 (EPA/DHA)", "omega3_index_target_percent": "10-12", "optimal_intake_g_EPA_DHA": "... |
NUT-MICRO-creatine-monohydrate | nutrition | micronutrient | Creatine Monohydrate | micronutrient | strength +5-15% | cognitive function (esp. vegetarians) | creatine kinase buffering | neuroprotection | anti-aging | [] | [
"strength +5-15%",
"cognitive function (esp. vegetarians)",
"creatine kinase buffering",
"neuroprotection",
"anti-aging"
] | {"benefits": ["strength +5-15%", "cognitive function (esp. vegetarians)", "creatine kinase buffering", "neuroprotection", "anti-aging"], "cost_per_month_usd": 5, "dose_g": 5, "evidence_level": "extremely strong — one of most studied supplements", "form": "creatine monohydrate — original, best studied", "frequency": "da... | null | extremely strong — one of most studied supplements | nutrition/nutrition_database.json | {"benefits": ["strength +5-15%", "cognitive function (esp. vegetarians)", "creatine kinase buffering", "neuroprotection", "anti-aging"], "cost_per_month_usd": 5, "dose_g": 5, "evidence_level": "extremely strong — one of most studied supplements", "form": "creatine monohydrate — original, best studied", "frequency": "da... |
NUT-MICRO-berberine | nutrition | micronutrient | Berberine | micronutrient | blood glucose comparable to metformin in T2D | LDL -25% | triglycerides -35% | weight loss | [
"AMPK activation (like metformin)",
"gut microbiome modulation",
"PCSK9 inhibition (lipids)",
"anti-inflammatory"
] | [
"blood glucose comparable to metformin in T2D",
"LDL -25%",
"triglycerides -35%",
"weight loss"
] | {"benefits": ["blood glucose comparable to metformin in T2D", "LDL -25%", "triglycerides -35%", "weight loss"], "dose_mg": "500 3x/day (1500 total)", "evidence_level": "strong", "mechanisms": ["AMPK activation (like metformin)", "gut microbiome modulation", "PCSK9 inhibition (lipids)", "anti-inflammatory"], "note": "Ha... | null | strong | nutrition/nutrition_database.json | {"benefits": ["blood glucose comparable to metformin in T2D", "LDL -25%", "triglycerides -35%", "weight loss"], "dose_mg": "500 3x/day (1500 total)", "evidence_level": "strong", "mechanisms": ["AMPK activation (like metformin)", "gut microbiome modulation", "PCSK9 inhibition (lipids)", "anti-inflammatory"], "note": "Ha... |
NUT-MICRO-curcumin-+-piperine | nutrition | micronutrient | Curcumin + Piperine | micronutrient | null | [
"NF-κB inhibition",
"COX-2 inhibition",
"BDNF upregulation",
"autophagy",
"epigenetic"
] | [] | {"dose_mg_curcumin": "500-1000", "evidence_level": "strong for inflammation, moderate for other claims", "form": "liposomal or phosphatidylcholine complex for best absorption", "mechanisms": ["NF-κB inhibition", "COX-2 inhibition", "BDNF upregulation", "autophagy", "epigenetic"], "nutrient": "Curcumin + Piperine", "pip... | null | strong for inflammation, moderate for other claims | nutrition/nutrition_database.json | {"dose_mg_curcumin": "500-1000", "evidence_level": "strong for inflammation, moderate for other claims", "form": "liposomal or phosphatidylcholine complex for best absorption", "mechanisms": ["NF-κB inhibition", "COX-2 inhibition", "BDNF upregulation", "autophagy", "epigenetic"], "nutrient": "Curcumin + Piperine", "pip... |
NUT-SNP-MTHFR-C677T | nutrition | nutrigenomics_snp | MTHFR C677T | nutrigenomics | elevated homocysteine | reduced SAM (methylation) | potential B12/folate deficiency despite 'normal' labs | [] | [
"elevated homocysteine",
"reduced SAM (methylation)",
"potential B12/folate deficiency despite 'normal' labs"
] | Methylfolate (5-MTHF) not folic acid | Methylcobalamin not cyanocobalamin | Betaine (TMG) 1-3g/day | Monitor homocysteine | null | null | nutrition/nutrition_database.json | {"effect": "Reduced methylenetetrahydrofolate reductase activity — impaired folate metabolism", "gene": "MTHFR", "implications": ["elevated homocysteine", "reduced SAM (methylation)", "potential B12/folate deficiency despite 'normal' labs"], "interventions": ["Methylfolate (5-MTHF) not folic acid", "Methylcobalamin not... |
NUT-SNP-APOE-ε4 | nutrition | nutrigenomics_snp | APOE ε4 | nutrigenomics | saturated fat → higher LDL response | omega-3 even more important | DHA uptake reduced | [] | [
"saturated fat → higher LDL response",
"omega-3 even more important",
"DHA uptake reduced"
] | Higher omega-3 DHA supplementation | Reduce saturated fat (stronger response vs non-ε4) | Earlier cognitive interventions | Lion's Mane, Bacopa — neuroprotective priority | null | null | nutrition/nutrition_database.json | {"effect": "Increased Alzheimer's risk, altered lipid metabolism", "gene": "APOE", "implications": ["saturated fat → higher LDL response", "omega-3 even more important", "DHA uptake reduced"], "interventions": ["Higher omega-3 DHA supplementation", "Reduce saturated fat (stronger response vs non-ε4)", "Earlier cognitiv... |
NUT-SNP-VDR-multiple | nutrition | nutrigenomics_snp | VDR multiple | nutrigenomics | need higher D3 doses for same effect | [] | [
"need higher D3 doses for same effect"
] | Target higher 25-OH D3 levels (80-100ng/mL vs 60-80) | null | null | nutrition/nutrition_database.json | {"effect": "Vitamin D receptor polymorphisms — reduced signaling", "gene": "VDR", "implications": ["need higher D3 doses for same effect"], "interventions": ["Target higher 25-OH D3 levels (80-100ng/mL vs 60-80)"], "variant": "multiple"} |
NUT-SNP-CYP1A2-rs762551 | nutrition | nutrigenomics_snp | CYP1A2 rs762551 | nutrigenomics | null | [] | [] | Slow metabolizers: limit caffeine to 1-2 cups, no afternoon caffeine | null | null | nutrition/nutrition_database.json | {"effect": "Caffeine metabolism speed", "fast_metabolizers": "1A allele — caffeine cleared quickly, cardiovascular protective", "gene": "CYP1A2", "interventions": ["Slow metabolizers: limit caffeine to 1-2 cups, no afternoon caffeine"], "slow_metabolizers": "1F allele — caffeine lingers, increased MI risk at high doses... |
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