id stringlengths 24 24 | title stringlengths 3 59 | context stringlengths 151 3.71k | question stringlengths 12 217 | answers dict |
|---|---|---|---|---|
57345902acc1501500babe24 | Richmond,_Virginia | In 1990 religion and politics intersected to impact the outcome of the Eighth District election in South Richmond. With the endorsements of black power brokers, black clergy and the Richmond Crusade for Voters, South Richmond residents made history, electing Reverend A. Carl Prince to the Richmond City Council. As the first African American Baptist Minister elected to the Richmond City Council, Prince's election paved the way for a political paradigm shift in politics that persist today. Following Prince's election, Reverend Gwendolyn Hedgepeth and the Reverend Leonidas Young, former Richmond Mayor were elected to public office. Prior to Prince's election black clergy made political endorsements and served as appointees to the Richmond School Board and other boards throughout the city. Today religion and politics continues to thrive in the Commonwealth of Virginia. The Honorable Dwight C. Jones, a prominent Baptist pastor and former Chairman of the Richmond School Board and Member of the Virginia House of Delegates serves as Mayor of the City of Richmond. | In what district did A. Carl Prince win election to the city council? | {
"text": [
"Eighth"
],
"answer_start": [
71
]
} |
57345902acc1501500babe25 | Richmond,_Virginia | In 1990 religion and politics intersected to impact the outcome of the Eighth District election in South Richmond. With the endorsements of black power brokers, black clergy and the Richmond Crusade for Voters, South Richmond residents made history, electing Reverend A. Carl Prince to the Richmond City Council. As the first African American Baptist Minister elected to the Richmond City Council, Prince's election paved the way for a political paradigm shift in politics that persist today. Following Prince's election, Reverend Gwendolyn Hedgepeth and the Reverend Leonidas Young, former Richmond Mayor were elected to public office. Prior to Prince's election black clergy made political endorsements and served as appointees to the Richmond School Board and other boards throughout the city. Today religion and politics continues to thrive in the Commonwealth of Virginia. The Honorable Dwight C. Jones, a prominent Baptist pastor and former Chairman of the Richmond School Board and Member of the Virginia House of Delegates serves as Mayor of the City of Richmond. | What political organization supported the city council candidacy of A. Carl Prince? | {
"text": [
"Richmond Crusade for Voters"
],
"answer_start": [
182
]
} |
5734596aacc1501500babe2b | Richmond,_Virginia | The city of Richmond operates 28 elementary schools, nine middle schools, and eight high schools, serving a total student population of 24,000 students. There is one Governor's School in the city − the Maggie L. Walker Governor's School for Government and International Studies. In 2008, it was named as one of Newsweek magazine's 18 "public elite" high schools, and in 2012, it was rated #16 of America's best high schools overall. Richmond's public school district also runs one of Virginia's four public charter schools, the Patrick Henry School of Science and Arts, which was founded in 2010. | How many high schools are there in Richmond? | {
"text": [
"eight"
],
"answer_start": [
78
]
} |
5734596aacc1501500babe2c | Richmond,_Virginia | The city of Richmond operates 28 elementary schools, nine middle schools, and eight high schools, serving a total student population of 24,000 students. There is one Governor's School in the city − the Maggie L. Walker Governor's School for Government and International Studies. In 2008, it was named as one of Newsweek magazine's 18 "public elite" high schools, and in 2012, it was rated #16 of America's best high schools overall. Richmond's public school district also runs one of Virginia's four public charter schools, the Patrick Henry School of Science and Arts, which was founded in 2010. | How many primary and secondary school students attend school in Richmond? | {
"text": [
"24,000"
],
"answer_start": [
136
]
} |
5734596aacc1501500babe2d | Richmond,_Virginia | The city of Richmond operates 28 elementary schools, nine middle schools, and eight high schools, serving a total student population of 24,000 students. There is one Governor's School in the city − the Maggie L. Walker Governor's School for Government and International Studies. In 2008, it was named as one of Newsweek magazine's 18 "public elite" high schools, and in 2012, it was rated #16 of America's best high schools overall. Richmond's public school district also runs one of Virginia's four public charter schools, the Patrick Henry School of Science and Arts, which was founded in 2010. | For whom is the Governor's School in Richmond named? | {
"text": [
"Maggie L. Walker"
],
"answer_start": [
202
]
} |
5734596aacc1501500babe2e | Richmond,_Virginia | The city of Richmond operates 28 elementary schools, nine middle schools, and eight high schools, serving a total student population of 24,000 students. There is one Governor's School in the city − the Maggie L. Walker Governor's School for Government and International Studies. In 2008, it was named as one of Newsweek magazine's 18 "public elite" high schools, and in 2012, it was rated #16 of America's best high schools overall. Richmond's public school district also runs one of Virginia's four public charter schools, the Patrick Henry School of Science and Arts, which was founded in 2010. | Where was Richmond's Governor's School rated by Newsweek in 2012? | {
"text": [
"16"
],
"answer_start": [
390
]
} |
5734596aacc1501500babe2f | Richmond,_Virginia | The city of Richmond operates 28 elementary schools, nine middle schools, and eight high schools, serving a total student population of 24,000 students. There is one Governor's School in the city − the Maggie L. Walker Governor's School for Government and International Studies. In 2008, it was named as one of Newsweek magazine's 18 "public elite" high schools, and in 2012, it was rated #16 of America's best high schools overall. Richmond's public school district also runs one of Virginia's four public charter schools, the Patrick Henry School of Science and Arts, which was founded in 2010. | When did Patrick Henry School of Science and Arts open its doors? | {
"text": [
"2010"
],
"answer_start": [
591
]
} |
573459cbacc1501500babe35 | Richmond,_Virginia | The Richmond area has many major institutions of higher education, including Virginia Commonwealth University (public), University of Richmond (private), Virginia Union University (private), Virginia College (private), South University - Richmond (private, for-profit), Union Theological Seminary & Presbyterian School of Christian Education (private), and the Baptist Theological Seminary in Richmond (BTSR—private). Several community colleges are found in the metro area, including J. Sargeant Reynolds Community College and John Tyler Community College (Chesterfield County). In addition, there are several Technical Colleges in Richmond including ITT Technical Institute, ECPI College of Technology and Centura College. There are several vocational colleges also, such as Fortis College and Bryant Stratton College. | What type of university is the University of Richmond? | {
"text": [
"private"
],
"answer_start": [
144
]
} |
573459cbacc1501500babe36 | Richmond,_Virginia | The Richmond area has many major institutions of higher education, including Virginia Commonwealth University (public), University of Richmond (private), Virginia Union University (private), Virginia College (private), South University - Richmond (private, for-profit), Union Theological Seminary & Presbyterian School of Christian Education (private), and the Baptist Theological Seminary in Richmond (BTSR—private). Several community colleges are found in the metro area, including J. Sargeant Reynolds Community College and John Tyler Community College (Chesterfield County). In addition, there are several Technical Colleges in Richmond including ITT Technical Institute, ECPI College of Technology and Centura College. There are several vocational colleges also, such as Fortis College and Bryant Stratton College. | What is a for-profit university in Richmond? | {
"text": [
"South University - Richmond"
],
"answer_start": [
219
]
} |
573459cbacc1501500babe37 | Richmond,_Virginia | The Richmond area has many major institutions of higher education, including Virginia Commonwealth University (public), University of Richmond (private), Virginia Union University (private), Virginia College (private), South University - Richmond (private, for-profit), Union Theological Seminary & Presbyterian School of Christian Education (private), and the Baptist Theological Seminary in Richmond (BTSR—private). Several community colleges are found in the metro area, including J. Sargeant Reynolds Community College and John Tyler Community College (Chesterfield County). In addition, there are several Technical Colleges in Richmond including ITT Technical Institute, ECPI College of Technology and Centura College. There are several vocational colleges also, such as Fortis College and Bryant Stratton College. | What does BTSR stand for? | {
"text": [
"Baptist Theological Seminary in Richmond"
],
"answer_start": [
361
]
} |
573459cbacc1501500babe38 | Richmond,_Virginia | The Richmond area has many major institutions of higher education, including Virginia Commonwealth University (public), University of Richmond (private), Virginia Union University (private), Virginia College (private), South University - Richmond (private, for-profit), Union Theological Seminary & Presbyterian School of Christian Education (private), and the Baptist Theological Seminary in Richmond (BTSR—private). Several community colleges are found in the metro area, including J. Sargeant Reynolds Community College and John Tyler Community College (Chesterfield County). In addition, there are several Technical Colleges in Richmond including ITT Technical Institute, ECPI College of Technology and Centura College. There are several vocational colleges also, such as Fortis College and Bryant Stratton College. | Where is John Tyler Community College located? | {
"text": [
"Chesterfield County"
],
"answer_start": [
557
]
} |
573459cbacc1501500babe39 | Richmond,_Virginia | The Richmond area has many major institutions of higher education, including Virginia Commonwealth University (public), University of Richmond (private), Virginia Union University (private), Virginia College (private), South University - Richmond (private, for-profit), Union Theological Seminary & Presbyterian School of Christian Education (private), and the Baptist Theological Seminary in Richmond (BTSR—private). Several community colleges are found in the metro area, including J. Sargeant Reynolds Community College and John Tyler Community College (Chesterfield County). In addition, there are several Technical Colleges in Richmond including ITT Technical Institute, ECPI College of Technology and Centura College. There are several vocational colleges also, such as Fortis College and Bryant Stratton College. | What is Richmond's public university? | {
"text": [
"Virginia Commonwealth"
],
"answer_start": [
77
]
} |
57345a6cacc1501500babe3f | Richmond,_Virginia | The Greater Richmond area is served by the Richmond International Airport (IATA: RIC, ICAO: KRIC), located in nearby Sandston, seven miles (11 km) southeast of Richmond and within an hour drive of historic Williamsburg, Virginia. Richmond International is now served by nine airlines with over 200 daily flights providing non-stop service to major destination markets and connecting flights to destinations worldwide. A record 3.3 million passengers used Richmond International Airport in 2006, a 13% increase over 2005. | How many kilometers away from Richmond is Richmond International Airport? | {
"text": [
"11"
],
"answer_start": [
140
]
} |
57345a6cacc1501500babe40 | Richmond,_Virginia | The Greater Richmond area is served by the Richmond International Airport (IATA: RIC, ICAO: KRIC), located in nearby Sandston, seven miles (11 km) southeast of Richmond and within an hour drive of historic Williamsburg, Virginia. Richmond International is now served by nine airlines with over 200 daily flights providing non-stop service to major destination markets and connecting flights to destinations worldwide. A record 3.3 million passengers used Richmond International Airport in 2006, a 13% increase over 2005. | About how long does it take to drive from Richmond International Airport to Williamsburg? | {
"text": [
"an hour"
],
"answer_start": [
180
]
} |
57345a6cacc1501500babe41 | Richmond,_Virginia | The Greater Richmond area is served by the Richmond International Airport (IATA: RIC, ICAO: KRIC), located in nearby Sandston, seven miles (11 km) southeast of Richmond and within an hour drive of historic Williamsburg, Virginia. Richmond International is now served by nine airlines with over 200 daily flights providing non-stop service to major destination markets and connecting flights to destinations worldwide. A record 3.3 million passengers used Richmond International Airport in 2006, a 13% increase over 2005. | How many airlines operate out of Richmond International? | {
"text": [
"nine"
],
"answer_start": [
270
]
} |
57345a6cacc1501500babe42 | Richmond,_Virginia | The Greater Richmond area is served by the Richmond International Airport (IATA: RIC, ICAO: KRIC), located in nearby Sandston, seven miles (11 km) southeast of Richmond and within an hour drive of historic Williamsburg, Virginia. Richmond International is now served by nine airlines with over 200 daily flights providing non-stop service to major destination markets and connecting flights to destinations worldwide. A record 3.3 million passengers used Richmond International Airport in 2006, a 13% increase over 2005. | What percentage increase in passenger traffic did Richmond International experience between 2005 and 2006? | {
"text": [
"13"
],
"answer_start": [
497
]
} |
57345a6cacc1501500babe43 | Richmond,_Virginia | The Greater Richmond area is served by the Richmond International Airport (IATA: RIC, ICAO: KRIC), located in nearby Sandston, seven miles (11 km) southeast of Richmond and within an hour drive of historic Williamsburg, Virginia. Richmond International is now served by nine airlines with over 200 daily flights providing non-stop service to major destination markets and connecting flights to destinations worldwide. A record 3.3 million passengers used Richmond International Airport in 2006, a 13% increase over 2005. | What direction do you travel to get from Richmond to Sandston? | {
"text": [
"southeast"
],
"answer_start": [
147
]
} |
57345b47879d6814001ca54d | Richmond,_Virginia | Richmond is a major hub for intercity bus company Greyhound Lines, with its terminal at 2910 N Boulevard. Multiple runs per day connect directly with Washington, D.C., New York, Raleigh, and elsewhere. Direct trips to New York take approximately 7.5 hours. Discount carrier Megabus also provides curbside service from outside of Main Street Station, with fares starting at $1. Direct service is available to Washington, D.C., Hampton Roads, Charlotte, Raleigh, Baltimore, and Philadelphia. Most other connections to Megabus served cites, such as New York, can be made from Washington, D.C. Richmond, and the surrounding metropolitan area, was granted[when?] a roughly $25 million grant from the U.S. Department of Transportation to support a newly proposed Rapid Transit System, which would run along Broad Street from Willow Lawn to Rocketts Landing, in the first phase of an improved public transportation hub for the region. | What is the street address if the Greyhound bus terminal in Richmond? | {
"text": [
"2910 N Boulevard"
],
"answer_start": [
88
]
} |
57345b47879d6814001ca54e | Richmond,_Virginia | Richmond is a major hub for intercity bus company Greyhound Lines, with its terminal at 2910 N Boulevard. Multiple runs per day connect directly with Washington, D.C., New York, Raleigh, and elsewhere. Direct trips to New York take approximately 7.5 hours. Discount carrier Megabus also provides curbside service from outside of Main Street Station, with fares starting at $1. Direct service is available to Washington, D.C., Hampton Roads, Charlotte, Raleigh, Baltimore, and Philadelphia. Most other connections to Megabus served cites, such as New York, can be made from Washington, D.C. Richmond, and the surrounding metropolitan area, was granted[when?] a roughly $25 million grant from the U.S. Department of Transportation to support a newly proposed Rapid Transit System, which would run along Broad Street from Willow Lawn to Rocketts Landing, in the first phase of an improved public transportation hub for the region. | How long does a bus trip from Richmond to New York City take? | {
"text": [
"7.5 hours"
],
"answer_start": [
246
]
} |
57345b47879d6814001ca54f | Richmond,_Virginia | Richmond is a major hub for intercity bus company Greyhound Lines, with its terminal at 2910 N Boulevard. Multiple runs per day connect directly with Washington, D.C., New York, Raleigh, and elsewhere. Direct trips to New York take approximately 7.5 hours. Discount carrier Megabus also provides curbside service from outside of Main Street Station, with fares starting at $1. Direct service is available to Washington, D.C., Hampton Roads, Charlotte, Raleigh, Baltimore, and Philadelphia. Most other connections to Megabus served cites, such as New York, can be made from Washington, D.C. Richmond, and the surrounding metropolitan area, was granted[when?] a roughly $25 million grant from the U.S. Department of Transportation to support a newly proposed Rapid Transit System, which would run along Broad Street from Willow Lawn to Rocketts Landing, in the first phase of an improved public transportation hub for the region. | What is the lowest fare on Megabus? | {
"text": [
"$1"
],
"answer_start": [
373
]
} |
57345b47879d6814001ca550 | Richmond,_Virginia | Richmond is a major hub for intercity bus company Greyhound Lines, with its terminal at 2910 N Boulevard. Multiple runs per day connect directly with Washington, D.C., New York, Raleigh, and elsewhere. Direct trips to New York take approximately 7.5 hours. Discount carrier Megabus also provides curbside service from outside of Main Street Station, with fares starting at $1. Direct service is available to Washington, D.C., Hampton Roads, Charlotte, Raleigh, Baltimore, and Philadelphia. Most other connections to Megabus served cites, such as New York, can be made from Washington, D.C. Richmond, and the surrounding metropolitan area, was granted[when?] a roughly $25 million grant from the U.S. Department of Transportation to support a newly proposed Rapid Transit System, which would run along Broad Street from Willow Lawn to Rocketts Landing, in the first phase of an improved public transportation hub for the region. | How much did the Department of Transportation give to Richmond for its Rapid Transit System? | {
"text": [
"$25 million"
],
"answer_start": [
668
]
} |
57345b47879d6814001ca551 | Richmond,_Virginia | Richmond is a major hub for intercity bus company Greyhound Lines, with its terminal at 2910 N Boulevard. Multiple runs per day connect directly with Washington, D.C., New York, Raleigh, and elsewhere. Direct trips to New York take approximately 7.5 hours. Discount carrier Megabus also provides curbside service from outside of Main Street Station, with fares starting at $1. Direct service is available to Washington, D.C., Hampton Roads, Charlotte, Raleigh, Baltimore, and Philadelphia. Most other connections to Megabus served cites, such as New York, can be made from Washington, D.C. Richmond, and the surrounding metropolitan area, was granted[when?] a roughly $25 million grant from the U.S. Department of Transportation to support a newly proposed Rapid Transit System, which would run along Broad Street from Willow Lawn to Rocketts Landing, in the first phase of an improved public transportation hub for the region. | What city in Maryland does Megabus travel to? | {
"text": [
"Baltimore"
],
"answer_start": [
461
]
} |
57345be2879d6814001ca557 | Richmond,_Virginia | Local transit and paratransit bus service in Richmond, Henrico, and Chesterfield counties is provided by the Greater Richmond Transit Company (GRTC). The GRTC, however, serves only small parts of the suburban counties. The far West End (Innsbrook and Short Pump) and almost all of Chesterfield County have no public transportation despite dense housing, retail, and office development. According to a 2008 GRTC operations analysis report, a majority of GRTC riders utilize their services because they do not have an available alternative such as a private vehicle. | What counties does the GRTC link to Richmond? | {
"text": [
"Henrico, and Chesterfield"
],
"answer_start": [
55
]
} |
57345be2879d6814001ca558 | Richmond,_Virginia | Local transit and paratransit bus service in Richmond, Henrico, and Chesterfield counties is provided by the Greater Richmond Transit Company (GRTC). The GRTC, however, serves only small parts of the suburban counties. The far West End (Innsbrook and Short Pump) and almost all of Chesterfield County have no public transportation despite dense housing, retail, and office development. According to a 2008 GRTC operations analysis report, a majority of GRTC riders utilize their services because they do not have an available alternative such as a private vehicle. | Along with Short Pump, what comprises the far part of the West End? | {
"text": [
"Innsbrook"
],
"answer_start": [
237
]
} |
57345be2879d6814001ca559 | Richmond,_Virginia | Local transit and paratransit bus service in Richmond, Henrico, and Chesterfield counties is provided by the Greater Richmond Transit Company (GRTC). The GRTC, however, serves only small parts of the suburban counties. The far West End (Innsbrook and Short Pump) and almost all of Chesterfield County have no public transportation despite dense housing, retail, and office development. According to a 2008 GRTC operations analysis report, a majority of GRTC riders utilize their services because they do not have an available alternative such as a private vehicle. | According to a GRTC report, what is an example of what most of its riders lack? | {
"text": [
"private vehicle"
],
"answer_start": [
548
]
} |
57345be2879d6814001ca55a | Richmond,_Virginia | Local transit and paratransit bus service in Richmond, Henrico, and Chesterfield counties is provided by the Greater Richmond Transit Company (GRTC). The GRTC, however, serves only small parts of the suburban counties. The far West End (Innsbrook and Short Pump) and almost all of Chesterfield County have no public transportation despite dense housing, retail, and office development. According to a 2008 GRTC operations analysis report, a majority of GRTC riders utilize their services because they do not have an available alternative such as a private vehicle. | What is GRTC an initialism of? | {
"text": [
"Greater Richmond Transit Company"
],
"answer_start": [
109
]
} |
57345c6a879d6814001ca55f | Richmond,_Virginia | The Richmond area also has two railroad stations served by Amtrak. Each station receives regular service from north of Richmond including Washington, D.C., Philadelphia, and New York. The suburban Staples Mill Road Station is located on a major north-south freight line and receives all service to and from all points south including, Raleigh, Durham, Savannah, Newport News, Williamsburg and Florida. Richmond's only railway station located within the city limits, the historic Main Street Station, was renovated in 2004. As of 2010, the station only receives trains headed to and from Newport News and Williamsburg due to track layout. As a result, the Staples Mill Road station receives more trains and serves more passengers overall. | What station services all southern rail traffic passing through Richmond? | {
"text": [
"Staples Mill Road Station"
],
"answer_start": [
197
]
} |
57345c6a879d6814001ca560 | Richmond,_Virginia | The Richmond area also has two railroad stations served by Amtrak. Each station receives regular service from north of Richmond including Washington, D.C., Philadelphia, and New York. The suburban Staples Mill Road Station is located on a major north-south freight line and receives all service to and from all points south including, Raleigh, Durham, Savannah, Newport News, Williamsburg and Florida. Richmond's only railway station located within the city limits, the historic Main Street Station, was renovated in 2004. As of 2010, the station only receives trains headed to and from Newport News and Williamsburg due to track layout. As a result, the Staples Mill Road station receives more trains and serves more passengers overall. | What is the name of the railroad station inside Richmond proper? | {
"text": [
"Main Street Station"
],
"answer_start": [
479
]
} |
57345c6a879d6814001ca561 | Richmond,_Virginia | The Richmond area also has two railroad stations served by Amtrak. Each station receives regular service from north of Richmond including Washington, D.C., Philadelphia, and New York. The suburban Staples Mill Road Station is located on a major north-south freight line and receives all service to and from all points south including, Raleigh, Durham, Savannah, Newport News, Williamsburg and Florida. Richmond's only railway station located within the city limits, the historic Main Street Station, was renovated in 2004. As of 2010, the station only receives trains headed to and from Newport News and Williamsburg due to track layout. As a result, the Staples Mill Road station receives more trains and serves more passengers overall. | In what year was Richmond's railroad station renovated? | {
"text": [
"2004"
],
"answer_start": [
517
]
} |
57345c6a879d6814001ca562 | Richmond,_Virginia | The Richmond area also has two railroad stations served by Amtrak. Each station receives regular service from north of Richmond including Washington, D.C., Philadelphia, and New York. The suburban Staples Mill Road Station is located on a major north-south freight line and receives all service to and from all points south including, Raleigh, Durham, Savannah, Newport News, Williamsburg and Florida. Richmond's only railway station located within the city limits, the historic Main Street Station, was renovated in 2004. As of 2010, the station only receives trains headed to and from Newport News and Williamsburg due to track layout. As a result, the Staples Mill Road station receives more trains and serves more passengers overall. | Along with Williamsburg, what city's rail traffic uses the Main Street Station? | {
"text": [
"Newport News"
],
"answer_start": [
587
]
} |
57345c6a879d6814001ca563 | Richmond,_Virginia | The Richmond area also has two railroad stations served by Amtrak. Each station receives regular service from north of Richmond including Washington, D.C., Philadelphia, and New York. The suburban Staples Mill Road Station is located on a major north-south freight line and receives all service to and from all points south including, Raleigh, Durham, Savannah, Newport News, Williamsburg and Florida. Richmond's only railway station located within the city limits, the historic Main Street Station, was renovated in 2004. As of 2010, the station only receives trains headed to and from Newport News and Williamsburg due to track layout. As a result, the Staples Mill Road station receives more trains and serves more passengers overall. | Why does the Main Street Station only receive rail traffic from Newport News and Williamsburg? | {
"text": [
"track layout"
],
"answer_start": [
624
]
} |
57345ceb879d6814001ca569 | Richmond,_Virginia | Electricity in the Richmond Metro area is provided by Dominion Virginia Power. The company, based in Richmond, is one of the nation's largest producers of energy, serving retail energy customers in nine states. Electricity is provided in the Richmond area primarily by the North Anna Nuclear Generating Station and Surry Nuclear Generating Station, as well as a coal-fired station in Chester, Virginia. These three plants provide a total of 4,453 megawatts of power. Several other natural gas plants provide extra power during times of peak demand. These include facilities in Chester, and Surry, and two plants in Richmond (Gravel Neck and Darbytown). | Who is Richmond's electricity supplier? | {
"text": [
"Dominion Virginia Power"
],
"answer_start": [
54
]
} |
57345ceb879d6814001ca56a | Richmond,_Virginia | Electricity in the Richmond Metro area is provided by Dominion Virginia Power. The company, based in Richmond, is one of the nation's largest producers of energy, serving retail energy customers in nine states. Electricity is provided in the Richmond area primarily by the North Anna Nuclear Generating Station and Surry Nuclear Generating Station, as well as a coal-fired station in Chester, Virginia. These three plants provide a total of 4,453 megawatts of power. Several other natural gas plants provide extra power during times of peak demand. These include facilities in Chester, and Surry, and two plants in Richmond (Gravel Neck and Darbytown). | How many states does Dominion Virginia Power operate in? | {
"text": [
"nine"
],
"answer_start": [
198
]
} |
57345ceb879d6814001ca56b | Richmond,_Virginia | Electricity in the Richmond Metro area is provided by Dominion Virginia Power. The company, based in Richmond, is one of the nation's largest producers of energy, serving retail energy customers in nine states. Electricity is provided in the Richmond area primarily by the North Anna Nuclear Generating Station and Surry Nuclear Generating Station, as well as a coal-fired station in Chester, Virginia. These three plants provide a total of 4,453 megawatts of power. Several other natural gas plants provide extra power during times of peak demand. These include facilities in Chester, and Surry, and two plants in Richmond (Gravel Neck and Darbytown). | Along with Surry Nuclear Generating Station, what is Richmond's main electricity generator? | {
"text": [
"North Anna Nuclear Generating Station"
],
"answer_start": [
273
]
} |
57345ceb879d6814001ca56c | Richmond,_Virginia | Electricity in the Richmond Metro area is provided by Dominion Virginia Power. The company, based in Richmond, is one of the nation's largest producers of energy, serving retail energy customers in nine states. Electricity is provided in the Richmond area primarily by the North Anna Nuclear Generating Station and Surry Nuclear Generating Station, as well as a coal-fired station in Chester, Virginia. These three plants provide a total of 4,453 megawatts of power. Several other natural gas plants provide extra power during times of peak demand. These include facilities in Chester, and Surry, and two plants in Richmond (Gravel Neck and Darbytown). | In what town is a coal-fired plant that provides power to Richmond located? | {
"text": [
"Chester"
],
"answer_start": [
384
]
} |
57345ceb879d6814001ca56d | Richmond,_Virginia | Electricity in the Richmond Metro area is provided by Dominion Virginia Power. The company, based in Richmond, is one of the nation's largest producers of energy, serving retail energy customers in nine states. Electricity is provided in the Richmond area primarily by the North Anna Nuclear Generating Station and Surry Nuclear Generating Station, as well as a coal-fired station in Chester, Virginia. These three plants provide a total of 4,453 megawatts of power. Several other natural gas plants provide extra power during times of peak demand. These include facilities in Chester, and Surry, and two plants in Richmond (Gravel Neck and Darbytown). | What type of power plant is Darbytown? | {
"text": [
"natural gas"
],
"answer_start": [
481
]
} |
57345d6a879d6814001ca573 | Richmond,_Virginia | The wastewater treatment plant and distribution system of water mains, pumping stations and storage facilities provide water to approximately 62,000 customers in the city. There is also a wastewater treatment plant located on the south bank of the James River. This plant can treat up to 70 million gallons of water per day of sanitary sewage and stormwater before returning it to the river. The wastewater utility also operates and maintains 1,500 miles (2,400 km) of sanitary sewer and pumping stations, 38 miles (61 km) of intercepting sewer lines, and the Shockoe Retention Basin, a 44-million-gallon stormwater reservoir used during heavy rains. | How many kilometers of sewer lines exist in Richmond? | {
"text": [
"61"
],
"answer_start": [
516
]
} |
57345d6a879d6814001ca574 | Richmond,_Virginia | The wastewater treatment plant and distribution system of water mains, pumping stations and storage facilities provide water to approximately 62,000 customers in the city. There is also a wastewater treatment plant located on the south bank of the James River. This plant can treat up to 70 million gallons of water per day of sanitary sewage and stormwater before returning it to the river. The wastewater utility also operates and maintains 1,500 miles (2,400 km) of sanitary sewer and pumping stations, 38 miles (61 km) of intercepting sewer lines, and the Shockoe Retention Basin, a 44-million-gallon stormwater reservoir used during heavy rains. | How much water is contained in Shockoe Retention Basin? | {
"text": [
"44-million-gallon"
],
"answer_start": [
587
]
} |
57345d6a879d6814001ca575 | Richmond,_Virginia | The wastewater treatment plant and distribution system of water mains, pumping stations and storage facilities provide water to approximately 62,000 customers in the city. There is also a wastewater treatment plant located on the south bank of the James River. This plant can treat up to 70 million gallons of water per day of sanitary sewage and stormwater before returning it to the river. The wastewater utility also operates and maintains 1,500 miles (2,400 km) of sanitary sewer and pumping stations, 38 miles (61 km) of intercepting sewer lines, and the Shockoe Retention Basin, a 44-million-gallon stormwater reservoir used during heavy rains. | How many Richmond inhabitants get their water from the wastewater treatment plant? | {
"text": [
"62,000"
],
"answer_start": [
142
]
} |
57345d6a879d6814001ca576 | Richmond,_Virginia | The wastewater treatment plant and distribution system of water mains, pumping stations and storage facilities provide water to approximately 62,000 customers in the city. There is also a wastewater treatment plant located on the south bank of the James River. This plant can treat up to 70 million gallons of water per day of sanitary sewage and stormwater before returning it to the river. The wastewater utility also operates and maintains 1,500 miles (2,400 km) of sanitary sewer and pumping stations, 38 miles (61 km) of intercepting sewer lines, and the Shockoe Retention Basin, a 44-million-gallon stormwater reservoir used during heavy rains. | How much sewage and stormwater can the treatment plant adjacent to the James River treat daily? | {
"text": [
"70 million gallons"
],
"answer_start": [
288
]
} |
57341ab74776f4190066187b | Infection | Among the vast varieties of microorganisms, relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen, depends upon the ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians therefore classify infectious microorganisms or microbes according to the status of host defenses - either as primary pathogens or as opportunistic pathogens: | Of the huge amount of microorganisms, how many cause disease in otherwise healthy individuals? | {
"text": [
"relatively few"
],
"answer_start": [
45
]
} |
57341ab74776f4190066187c | Infection | Among the vast varieties of microorganisms, relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen, depends upon the ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians therefore classify infectious microorganisms or microbes according to the status of host defenses - either as primary pathogens or as opportunistic pathogens: | Interplay between pathogens and defenses of hosts results in what? | {
"text": [
"Infectious disease"
],
"answer_start": [
108
]
} |
57341ab74776f4190066187d | Infection | Among the vast varieties of microorganisms, relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen, depends upon the ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians therefore classify infectious microorganisms or microbes according to the status of host defenses - either as primary pathogens or as opportunistic pathogens: | What does the severity of a disease resulting from a pathogen depend on? | {
"text": [
"ability of that pathogen to damage the host"
],
"answer_start": [
310
]
} |
57341ab74776f4190066187e | Infection | Among the vast varieties of microorganisms, relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen, depends upon the ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians therefore classify infectious microorganisms or microbes according to the status of host defenses - either as primary pathogens or as opportunistic pathogens: | What can a host's immune system do to a host? | {
"text": [
"cause damage"
],
"answer_start": [
453
]
} |
57341ab74776f4190066187f | Infection | Among the vast varieties of microorganisms, relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen, depends upon the ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians therefore classify infectious microorganisms or microbes according to the status of host defenses - either as primary pathogens or as opportunistic pathogens: | What do clinicians classify infectious microorganisms according to the status of? | {
"text": [
"host defenses"
],
"answer_start": [
620
]
} |
57341bef4776f41900661897 | Infection | One way of proving that a given disease is "infectious", is to satisfy Koch's postulates (first proposed by Robert Koch), which demands that the infectious agent be identified only in patients and not in healthy controls, and that patients who contract the agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis. Koch's postulates can not be applied ethically for many human diseases because they require experimental infection of a healthy individual with a pathogen produced as a pure culture. Often, even clearly infectious diseases do not meet the infectious criteria. For example, Treponema pallidum, the causative spirochete of syphilis, cannot be cultured in vitro - however the organism can be cultured in rabbit testes. It is less clear that a pure culture comes from an animal source serving as host than it is when derived from microbes derived from plate culture. Epidemiology is another important tool used to study disease in a population. For infectious diseases it helps to determine if a disease outbreak is sporadic (occasional occurrence), endemic (regular cases often occurring in a region), epidemic (an unusually high number of cases in a region), or pandemic (a global epidemic). | What is one way of proving that a given disease is infectious? | {
"text": [
"satisfy Koch's postulates"
],
"answer_start": [
63
]
} |
57341bef4776f41900661898 | Infection | One way of proving that a given disease is "infectious", is to satisfy Koch's postulates (first proposed by Robert Koch), which demands that the infectious agent be identified only in patients and not in healthy controls, and that patients who contract the agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis. Koch's postulates can not be applied ethically for many human diseases because they require experimental infection of a healthy individual with a pathogen produced as a pure culture. Often, even clearly infectious diseases do not meet the infectious criteria. For example, Treponema pallidum, the causative spirochete of syphilis, cannot be cultured in vitro - however the organism can be cultured in rabbit testes. It is less clear that a pure culture comes from an animal source serving as host than it is when derived from microbes derived from plate culture. Epidemiology is another important tool used to study disease in a population. For infectious diseases it helps to determine if a disease outbreak is sporadic (occasional occurrence), endemic (regular cases often occurring in a region), epidemic (an unusually high number of cases in a region), or pandemic (a global epidemic). | What must an infectious agent only be identified in to satisfy the first of Koch's postulates? | {
"text": [
"patients and not in healthy controls"
],
"answer_start": [
184
]
} |
57341bef4776f41900661899 | Infection | One way of proving that a given disease is "infectious", is to satisfy Koch's postulates (first proposed by Robert Koch), which demands that the infectious agent be identified only in patients and not in healthy controls, and that patients who contract the agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis. Koch's postulates can not be applied ethically for many human diseases because they require experimental infection of a healthy individual with a pathogen produced as a pure culture. Often, even clearly infectious diseases do not meet the infectious criteria. For example, Treponema pallidum, the causative spirochete of syphilis, cannot be cultured in vitro - however the organism can be cultured in rabbit testes. It is less clear that a pure culture comes from an animal source serving as host than it is when derived from microbes derived from plate culture. Epidemiology is another important tool used to study disease in a population. For infectious diseases it helps to determine if a disease outbreak is sporadic (occasional occurrence), endemic (regular cases often occurring in a region), epidemic (an unusually high number of cases in a region), or pandemic (a global epidemic). | What is Koch's second postulate? | {
"text": [
"patients who contract the agent also develop the disease"
],
"answer_start": [
231
]
} |
57341bef4776f4190066189a | Infection | One way of proving that a given disease is "infectious", is to satisfy Koch's postulates (first proposed by Robert Koch), which demands that the infectious agent be identified only in patients and not in healthy controls, and that patients who contract the agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis. Koch's postulates can not be applied ethically for many human diseases because they require experimental infection of a healthy individual with a pathogen produced as a pure culture. Often, even clearly infectious diseases do not meet the infectious criteria. For example, Treponema pallidum, the causative spirochete of syphilis, cannot be cultured in vitro - however the organism can be cultured in rabbit testes. It is less clear that a pure culture comes from an animal source serving as host than it is when derived from microbes derived from plate culture. Epidemiology is another important tool used to study disease in a population. For infectious diseases it helps to determine if a disease outbreak is sporadic (occasional occurrence), endemic (regular cases often occurring in a region), epidemic (an unusually high number of cases in a region), or pandemic (a global epidemic). | Why can't Koch's postulates be applied ethically for many human diseases? | {
"text": [
"because they require experimental infection of a healthy individual"
],
"answer_start": [
456
]
} |
57341bef4776f4190066189b | Infection | One way of proving that a given disease is "infectious", is to satisfy Koch's postulates (first proposed by Robert Koch), which demands that the infectious agent be identified only in patients and not in healthy controls, and that patients who contract the agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis. Koch's postulates can not be applied ethically for many human diseases because they require experimental infection of a healthy individual with a pathogen produced as a pure culture. Often, even clearly infectious diseases do not meet the infectious criteria. For example, Treponema pallidum, the causative spirochete of syphilis, cannot be cultured in vitro - however the organism can be cultured in rabbit testes. It is less clear that a pure culture comes from an animal source serving as host than it is when derived from microbes derived from plate culture. Epidemiology is another important tool used to study disease in a population. For infectious diseases it helps to determine if a disease outbreak is sporadic (occasional occurrence), endemic (regular cases often occurring in a region), epidemic (an unusually high number of cases in a region), or pandemic (a global epidemic). | What is the causative spirochete of syphilis? | {
"text": [
"Treponema pallidum"
],
"answer_start": [
658
]
} |
57341c75d058e614000b695b | Infection | Infectious diseases are sometimes called contagious disease when they are easily transmitted by contact with an ill person or their secretions (e.g., influenza). Thus, a contagious disease is a subset of infectious disease that is especially infective or easily transmitted. Other types of infectious/transmissible/communicable diseases with more specialized routes of infection, such as vector transmission or sexual transmission, are usually not regarded as "contagious", and often do not require medical isolation (sometimes loosely called quarantine) of victims. However, this specialized connotation of the word "contagious" and "contagious disease" (easy transmissibility) is not always respected in popular use. | What is a contagious disease a subset of? | {
"text": [
"infectious disease"
],
"answer_start": [
204
]
} |
57341c75d058e614000b695c | Infection | Infectious diseases are sometimes called contagious disease when they are easily transmitted by contact with an ill person or their secretions (e.g., influenza). Thus, a contagious disease is a subset of infectious disease that is especially infective or easily transmitted. Other types of infectious/transmissible/communicable diseases with more specialized routes of infection, such as vector transmission or sexual transmission, are usually not regarded as "contagious", and often do not require medical isolation (sometimes loosely called quarantine) of victims. However, this specialized connotation of the word "contagious" and "contagious disease" (easy transmissibility) is not always respected in popular use. | What sets a contagious disease after from a standard infectious disease? | {
"text": [
"especially infective or easily transmitted"
],
"answer_start": [
231
]
} |
57341c75d058e614000b695d | Infection | Infectious diseases are sometimes called contagious disease when they are easily transmitted by contact with an ill person or their secretions (e.g., influenza). Thus, a contagious disease is a subset of infectious disease that is especially infective or easily transmitted. Other types of infectious/transmissible/communicable diseases with more specialized routes of infection, such as vector transmission or sexual transmission, are usually not regarded as "contagious", and often do not require medical isolation (sometimes loosely called quarantine) of victims. However, this specialized connotation of the word "contagious" and "contagious disease" (easy transmissibility) is not always respected in popular use. | Diseases with vector transmission or sexual transmission don't often require what type of isolation? | {
"text": [
"medical"
],
"answer_start": [
499
]
} |
57341c75d058e614000b695e | Infection | Infectious diseases are sometimes called contagious disease when they are easily transmitted by contact with an ill person or their secretions (e.g., influenza). Thus, a contagious disease is a subset of infectious disease that is especially infective or easily transmitted. Other types of infectious/transmissible/communicable diseases with more specialized routes of infection, such as vector transmission or sexual transmission, are usually not regarded as "contagious", and often do not require medical isolation (sometimes loosely called quarantine) of victims. However, this specialized connotation of the word "contagious" and "contagious disease" (easy transmissibility) is not always respected in popular use. | What is not always respected in popular use? | {
"text": [
"specialized connotation of the word \"contagious\""
],
"answer_start": [
581
]
} |
57341d3f4776f419006618a9 | Infection | Infection begins when an organism successfully enters the body, grows and multiplies. This is referred to as colonization. Most humans are not easily infected. Those who are weak, sick, malnourished, have cancer or are diabetic have increased susceptibility to chronic or persistent infections. Individuals who have a suppressed immune system are particularly susceptible to opportunistic infections. Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, eyes, genitalia, anus, or the microbe can enter through open wounds. While a few organisms can grow at the initial site of entry, many migrate and cause systemic infection in different organs. Some pathogens grow within the host cells (intracellular) whereas others grow freely in bodily fluids. | When does infection begin? | {
"text": [
"when an organism successfully enters the body, grows and multiplies."
],
"answer_start": [
17
]
} |
57341d3f4776f419006618aa | Infection | Infection begins when an organism successfully enters the body, grows and multiplies. This is referred to as colonization. Most humans are not easily infected. Those who are weak, sick, malnourished, have cancer or are diabetic have increased susceptibility to chronic or persistent infections. Individuals who have a suppressed immune system are particularly susceptible to opportunistic infections. Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, eyes, genitalia, anus, or the microbe can enter through open wounds. While a few organisms can grow at the initial site of entry, many migrate and cause systemic infection in different organs. Some pathogens grow within the host cells (intracellular) whereas others grow freely in bodily fluids. | What group is not easily infected? | {
"text": [
"humans"
],
"answer_start": [
128
]
} |
57341d3f4776f419006618ab | Infection | Infection begins when an organism successfully enters the body, grows and multiplies. This is referred to as colonization. Most humans are not easily infected. Those who are weak, sick, malnourished, have cancer or are diabetic have increased susceptibility to chronic or persistent infections. Individuals who have a suppressed immune system are particularly susceptible to opportunistic infections. Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, eyes, genitalia, anus, or the microbe can enter through open wounds. While a few organisms can grow at the initial site of entry, many migrate and cause systemic infection in different organs. Some pathogens grow within the host cells (intracellular) whereas others grow freely in bodily fluids. | What group of humans have increased susceptibility to chronic or persistent infections? | {
"text": [
"weak, sick, malnourished, have cancer or are diabetic"
],
"answer_start": [
174
]
} |
57341d3f4776f419006618ac | Infection | Infection begins when an organism successfully enters the body, grows and multiplies. This is referred to as colonization. Most humans are not easily infected. Those who are weak, sick, malnourished, have cancer or are diabetic have increased susceptibility to chronic or persistent infections. Individuals who have a suppressed immune system are particularly susceptible to opportunistic infections. Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, eyes, genitalia, anus, or the microbe can enter through open wounds. While a few organisms can grow at the initial site of entry, many migrate and cause systemic infection in different organs. Some pathogens grow within the host cells (intracellular) whereas others grow freely in bodily fluids. | What individuals are particularly susceptible to opportunistic infections? | {
"text": [
"Individuals who have a suppressed immune system"
],
"answer_start": [
295
]
} |
57341d3f4776f419006618ad | Infection | Infection begins when an organism successfully enters the body, grows and multiplies. This is referred to as colonization. Most humans are not easily infected. Those who are weak, sick, malnourished, have cancer or are diabetic have increased susceptibility to chronic or persistent infections. Individuals who have a suppressed immune system are particularly susceptible to opportunistic infections. Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, eyes, genitalia, anus, or the microbe can enter through open wounds. While a few organisms can grow at the initial site of entry, many migrate and cause systemic infection in different organs. Some pathogens grow within the host cells (intracellular) whereas others grow freely in bodily fluids. | What is it called when a pathogen grows within the host cells? | {
"text": [
"intracellular"
],
"answer_start": [
762
]
} |
57341dc0d058e614000b696a | Infection | Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter is various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing. | What does wound colonization refer to? | {
"text": [
"nonreplicating microorganisms within the wound"
],
"answer_start": [
29
]
} |
57341dc0d058e614000b696b | Infection | Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter is various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing. | What type of organisms exist and injure tissue in infected wounds? | {
"text": [
"replicating"
],
"answer_start": [
103
]
} |
57341dc0d058e614000b696c | Infection | Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter is various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing. | What are all multcellular organisms colonized to some degree by? | {
"text": [
"extrinsic organisms"
],
"answer_start": [
214
]
} |
57341dc0d058e614000b696d | Infection | Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter is various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing. | What species colonizes the mammalian colon? | {
"text": [
"anaerobic bacteria"
],
"answer_start": [
369
]
} |
57341dc0d058e614000b696e | Infection | Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter is various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing. | What's the difference between an infection and a colonization? | {
"text": [
"only a matter of circumstance"
],
"answer_start": [
648
]
} |
57341e404776f419006618c3 | Infection | Because it is normal to have bacterial colonization, it is difficult to know which chronic wounds are infected. Despite the huge number of wounds seen in clinical practice, there are limited quality data for evaluated symptoms and signs. A review of chronic wounds in the Journal of the American Medical Association's "Rational Clinical Examination Series" quantified the importance of increased pain as an indicator of infection. The review showed that the most useful finding is an increase in the level of pain [likelihood ratio (LR) range, 11-20] makes infection much more likely, but the absence of pain (negative likelihood ratio range, 0.64-0.88) does not rule out infection (summary LR 0.64-0.88). | Why is it difficult to now which chronic wounds are infected? | {
"text": [
"Because it is normal to have bacterial colonization"
],
"answer_start": [
0
]
} |
57341e404776f419006618c4 | Infection | Because it is normal to have bacterial colonization, it is difficult to know which chronic wounds are infected. Despite the huge number of wounds seen in clinical practice, there are limited quality data for evaluated symptoms and signs. A review of chronic wounds in the Journal of the American Medical Association's "Rational Clinical Examination Series" quantified the importance of increased pain as an indicator of infection. The review showed that the most useful finding is an increase in the level of pain [likelihood ratio (LR) range, 11-20] makes infection much more likely, but the absence of pain (negative likelihood ratio range, 0.64-0.88) does not rule out infection (summary LR 0.64-0.88). | What is there limited quality data for evaluating despite the huge number of wounds seen in a clinical practice? | {
"text": [
"symptoms and signs"
],
"answer_start": [
218
]
} |
57341e404776f419006618c5 | Infection | Because it is normal to have bacterial colonization, it is difficult to know which chronic wounds are infected. Despite the huge number of wounds seen in clinical practice, there are limited quality data for evaluated symptoms and signs. A review of chronic wounds in the Journal of the American Medical Association's "Rational Clinical Examination Series" quantified the importance of increased pain as an indicator of infection. The review showed that the most useful finding is an increase in the level of pain [likelihood ratio (LR) range, 11-20] makes infection much more likely, but the absence of pain (negative likelihood ratio range, 0.64-0.88) does not rule out infection (summary LR 0.64-0.88). | What is increased pain an indicator of? | {
"text": [
"infection"
],
"answer_start": [
420
]
} |
57341e404776f419006618c6 | Infection | Because it is normal to have bacterial colonization, it is difficult to know which chronic wounds are infected. Despite the huge number of wounds seen in clinical practice, there are limited quality data for evaluated symptoms and signs. A review of chronic wounds in the Journal of the American Medical Association's "Rational Clinical Examination Series" quantified the importance of increased pain as an indicator of infection. The review showed that the most useful finding is an increase in the level of pain [likelihood ratio (LR) range, 11-20] makes infection much more likely, but the absence of pain (negative likelihood ratio range, 0.64-0.88) does not rule out infection (summary LR 0.64-0.88). | What does not rule out infection? | {
"text": [
"absence of pain"
],
"answer_start": [
593
]
} |
57341fdd4776f419006618d3 | Infection | Disease can arise if the host's protective immune mechanisms are compromised and the organism inflicts damage on the host. Microorganisms can cause tissue damage by releasing a variety of toxins or destructive enzymes. For example, Clostridium tetani releases a toxin that paralyzes muscles, and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop disease. On the other hand, some infectious agents are highly virulent. The prion causing mad cow disease and Creutzfeldt–Jakob disease invariably kills all animals and people that are infected. | Disease can arise when an organism inflicts what on the host? | {
"text": [
"damage"
],
"answer_start": [
103
]
} |
57341fdd4776f419006618d4 | Infection | Disease can arise if the host's protective immune mechanisms are compromised and the organism inflicts damage on the host. Microorganisms can cause tissue damage by releasing a variety of toxins or destructive enzymes. For example, Clostridium tetani releases a toxin that paralyzes muscles, and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop disease. On the other hand, some infectious agents are highly virulent. The prion causing mad cow disease and Creutzfeldt–Jakob disease invariably kills all animals and people that are infected. | What can a microorganism cause tissue damage by releasing a variety of? | {
"text": [
"toxins"
],
"answer_start": [
188
]
} |
57341fdd4776f419006618d5 | Infection | Disease can arise if the host's protective immune mechanisms are compromised and the organism inflicts damage on the host. Microorganisms can cause tissue damage by releasing a variety of toxins or destructive enzymes. For example, Clostridium tetani releases a toxin that paralyzes muscles, and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop disease. On the other hand, some infectious agents are highly virulent. The prion causing mad cow disease and Creutzfeldt–Jakob disease invariably kills all animals and people that are infected. | What does the of toxin Clostridium tetani releases do? | {
"text": [
"paralyzes muscles"
],
"answer_start": [
273
]
} |
57341fdd4776f419006618d6 | Infection | Disease can arise if the host's protective immune mechanisms are compromised and the organism inflicts damage on the host. Microorganisms can cause tissue damage by releasing a variety of toxins or destructive enzymes. For example, Clostridium tetani releases a toxin that paralyzes muscles, and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop disease. On the other hand, some infectious agents are highly virulent. The prion causing mad cow disease and Creutzfeldt–Jakob disease invariably kills all animals and people that are infected. | What releases toxins which product shock and sepsis? | {
"text": [
"staphylococcus"
],
"answer_start": [
296
]
} |
57341fdd4776f419006618d7 | Infection | Disease can arise if the host's protective immune mechanisms are compromised and the organism inflicts damage on the host. Microorganisms can cause tissue damage by releasing a variety of toxins or destructive enzymes. For example, Clostridium tetani releases a toxin that paralyzes muscles, and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop disease. On the other hand, some infectious agents are highly virulent. The prion causing mad cow disease and Creutzfeldt–Jakob disease invariably kills all animals and people that are infected. | What percentage of people infected with polio develop disease? | {
"text": [
"less than 5%"
],
"answer_start": [
425
]
} |
5734203ed058e614000b6983 | Infection | Persistent infections occur because the body is unable to clear the organism after the initial infection. Persistent infections are characterized by the continual presence of the infectious organism, often as latent infection with occasional recurrent relapses of active infection. There are some viruses that can maintain a persistent infection by infecting different cells of the body. Some viruses once acquired never leave the body. A typical example is the herpes virus, which tends to hide in nerves and become reactivated when specific circumstances arise. | What are persistent infections characterized by the continual presence of? | {
"text": [
"the infectious organism"
],
"answer_start": [
175
]
} |
5734203ed058e614000b6984 | Infection | Persistent infections occur because the body is unable to clear the organism after the initial infection. Persistent infections are characterized by the continual presence of the infectious organism, often as latent infection with occasional recurrent relapses of active infection. There are some viruses that can maintain a persistent infection by infecting different cells of the body. Some viruses once acquired never leave the body. A typical example is the herpes virus, which tends to hide in nerves and become reactivated when specific circumstances arise. | How can some viruses main a persistent infection? | {
"text": [
"by infecting different cells of the body"
],
"answer_start": [
346
]
} |
5734203ed058e614000b6985 | Infection | Persistent infections occur because the body is unable to clear the organism after the initial infection. Persistent infections are characterized by the continual presence of the infectious organism, often as latent infection with occasional recurrent relapses of active infection. There are some viruses that can maintain a persistent infection by infecting different cells of the body. Some viruses once acquired never leave the body. A typical example is the herpes virus, which tends to hide in nerves and become reactivated when specific circumstances arise. | What never leave the body when acquired? | {
"text": [
"Some viruses"
],
"answer_start": [
388
]
} |
5734203ed058e614000b6986 | Infection | Persistent infections occur because the body is unable to clear the organism after the initial infection. Persistent infections are characterized by the continual presence of the infectious organism, often as latent infection with occasional recurrent relapses of active infection. There are some viruses that can maintain a persistent infection by infecting different cells of the body. Some viruses once acquired never leave the body. A typical example is the herpes virus, which tends to hide in nerves and become reactivated when specific circumstances arise. | Where does the herpes virus hide? | {
"text": [
"in nerves"
],
"answer_start": [
496
]
} |
573420d9d058e614000b6996 | Infection | Diagnosis of infectious disease sometimes involves identifying an infectious agent either directly or indirectly. In practice most minor infectious diseases such as warts, cutaneous abscesses, respiratory system infections and diarrheal diseases are diagnosed by their clinical presentation and treated without knowledge of the specific causative agent. Conclusions about the cause of the disease are based upon the likelihood that a patient came in contact with a particular agent, the presence of a microbe in a community, and other epidemiological considerations. Given sufficient effort, all known infectious agents can be specifically identified. The benefits of identification, however, are often greatly outweighed by the cost, as often there is no specific treatment, the cause is obvious, or the outcome of an infection is benign. | What does diagnosis of an infectious sometimes involve identifying? | {
"text": [
"an infectious agent either directly or indirectly"
],
"answer_start": [
63
]
} |
573420d9d058e614000b6997 | Infection | Diagnosis of infectious disease sometimes involves identifying an infectious agent either directly or indirectly. In practice most minor infectious diseases such as warts, cutaneous abscesses, respiratory system infections and diarrheal diseases are diagnosed by their clinical presentation and treated without knowledge of the specific causative agent. Conclusions about the cause of the disease are based upon the likelihood that a patient came in contact with a particular agent, the presence of a microbe in a community, and other epidemiological considerations. Given sufficient effort, all known infectious agents can be specifically identified. The benefits of identification, however, are often greatly outweighed by the cost, as often there is no specific treatment, the cause is obvious, or the outcome of an infection is benign. | Many minor infectious diseases are diagnosed by what type of presentation? | {
"text": [
"clinical"
],
"answer_start": [
269
]
} |
573420d9d058e614000b6998 | Infection | Diagnosis of infectious disease sometimes involves identifying an infectious agent either directly or indirectly. In practice most minor infectious diseases such as warts, cutaneous abscesses, respiratory system infections and diarrheal diseases are diagnosed by their clinical presentation and treated without knowledge of the specific causative agent. Conclusions about the cause of the disease are based upon the likelihood that a patient came in contact with a particular agent, the presence of a microbe in a community, and other epidemiological considerations. Given sufficient effort, all known infectious agents can be specifically identified. The benefits of identification, however, are often greatly outweighed by the cost, as often there is no specific treatment, the cause is obvious, or the outcome of an infection is benign. | How are minor infectious diseases treated? | {
"text": [
"without knowledge of the specific causative agent"
],
"answer_start": [
303
]
} |
573420d9d058e614000b6999 | Infection | Diagnosis of infectious disease sometimes involves identifying an infectious agent either directly or indirectly. In practice most minor infectious diseases such as warts, cutaneous abscesses, respiratory system infections and diarrheal diseases are diagnosed by their clinical presentation and treated without knowledge of the specific causative agent. Conclusions about the cause of the disease are based upon the likelihood that a patient came in contact with a particular agent, the presence of a microbe in a community, and other epidemiological considerations. Given sufficient effort, all known infectious agents can be specifically identified. The benefits of identification, however, are often greatly outweighed by the cost, as often there is no specific treatment, the cause is obvious, or the outcome of an infection is benign. | What can be identified given sufficient effort? | {
"text": [
"all known infectious agents"
],
"answer_start": [
592
]
} |
573420d9d058e614000b699a | Infection | Diagnosis of infectious disease sometimes involves identifying an infectious agent either directly or indirectly. In practice most minor infectious diseases such as warts, cutaneous abscesses, respiratory system infections and diarrheal diseases are diagnosed by their clinical presentation and treated without knowledge of the specific causative agent. Conclusions about the cause of the disease are based upon the likelihood that a patient came in contact with a particular agent, the presence of a microbe in a community, and other epidemiological considerations. Given sufficient effort, all known infectious agents can be specifically identified. The benefits of identification, however, are often greatly outweighed by the cost, as often there is no specific treatment, the cause is obvious, or the outcome of an infection is benign. | Why is it often not worth bothering to identify an infectious agent? | {
"text": [
"greatly outweighed by the cost"
],
"answer_start": [
703
]
} |
573421ecd058e614000b69b2 | Infection | Diagnosis of infectious disease is nearly always initiated by medical history and physical examination. More detailed identification techniques involve the culture of infectious agents isolated from a patient. Culture allows identification of infectious organisms by examining their microscopic features, by detecting the presence of substances produced by pathogens, and by directly identifying an organism by its genotype. Other techniques (such as X-rays, CAT scans, PET scans or NMR) are used to produce images of internal abnormalities resulting from the growth of an infectious agent. The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by a prion. | How is diagnosis of infectious disease almost always initiated? | {
"text": [
"by medical history and physical examination"
],
"answer_start": [
59
]
} |
573421ecd058e614000b69b3 | Infection | Diagnosis of infectious disease is nearly always initiated by medical history and physical examination. More detailed identification techniques involve the culture of infectious agents isolated from a patient. Culture allows identification of infectious organisms by examining their microscopic features, by detecting the presence of substances produced by pathogens, and by directly identifying an organism by its genotype. Other techniques (such as X-rays, CAT scans, PET scans or NMR) are used to produce images of internal abnormalities resulting from the growth of an infectious agent. The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by a prion. | What does taking a culture of an infectious agent isolated from a patient allow? | {
"text": [
"detailed identification"
],
"answer_start": [
109
]
} |
573421ecd058e614000b69b4 | Infection | Diagnosis of infectious disease is nearly always initiated by medical history and physical examination. More detailed identification techniques involve the culture of infectious agents isolated from a patient. Culture allows identification of infectious organisms by examining their microscopic features, by detecting the presence of substances produced by pathogens, and by directly identifying an organism by its genotype. Other techniques (such as X-rays, CAT scans, PET scans or NMR) are used to produce images of internal abnormalities resulting from the growth of an infectious agent. The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by a prion. | What features of an infectious organism does a culture allow examining? | {
"text": [
"microscopic features"
],
"answer_start": [
283
]
} |
573421ecd058e614000b69b5 | Infection | Diagnosis of infectious disease is nearly always initiated by medical history and physical examination. More detailed identification techniques involve the culture of infectious agents isolated from a patient. Culture allows identification of infectious organisms by examining their microscopic features, by detecting the presence of substances produced by pathogens, and by directly identifying an organism by its genotype. Other techniques (such as X-rays, CAT scans, PET scans or NMR) are used to produce images of internal abnormalities resulting from the growth of an infectious agent. The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by a prion. | What can organisms be directly identified by? | {
"text": [
"its genotype"
],
"answer_start": [
411
]
} |
573421ecd058e614000b69b6 | Infection | Diagnosis of infectious disease is nearly always initiated by medical history and physical examination. More detailed identification techniques involve the culture of infectious agents isolated from a patient. Culture allows identification of infectious organisms by examining their microscopic features, by detecting the presence of substances produced by pathogens, and by directly identifying an organism by its genotype. Other techniques (such as X-rays, CAT scans, PET scans or NMR) are used to produce images of internal abnormalities resulting from the growth of an infectious agent. The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by a prion. | What technique can be used to produce images of internal abnormalities? | {
"text": [
"X-rays, CAT scans, PET scans or NMR"
],
"answer_start": [
451
]
} |
573422a84776f4190066191d | Infection | Microbiological culture is a principal tool used to diagnose infectious disease. In a microbial culture, a growth medium is provided for a specific agent. A sample taken from potentially diseased tissue or fluid is then tested for the presence of an infectious agent able to grow within that medium. Most pathogenic bacteria are easily grown on nutrient agar, a form of solid medium that supplies carbohydrates and proteins necessary for growth of a bacterium, along with copious amounts of water. A single bacterium will grow into a visible mound on the surface of the plate called a colony, which may be separated from other colonies or melded together into a "lawn". The size, color, shape and form of a colony is characteristic of the bacterial species, its specific genetic makeup (its strain), and the environment that supports its growth. Other ingredients are often added to the plate to aid in identification. Plates may contain substances that permit the growth of some bacteria and not others, or that change color in response to certain bacteria and not others. Bacteriological plates such as these are commonly used in the clinical identification of infectious bacterium. Microbial culture may also be used in the identification of viruses: the medium in this case being cells grown in culture that the virus can infect, and then alter or kill. In the case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic parasites may also be grown in culture as a means of identifying a particular agent. | What type of culture is a principal tool used to diagnose infectious disease? | {
"text": [
"Microbiological"
],
"answer_start": [
0
]
} |
573422a84776f4190066191e | Infection | Microbiological culture is a principal tool used to diagnose infectious disease. In a microbial culture, a growth medium is provided for a specific agent. A sample taken from potentially diseased tissue or fluid is then tested for the presence of an infectious agent able to grow within that medium. Most pathogenic bacteria are easily grown on nutrient agar, a form of solid medium that supplies carbohydrates and proteins necessary for growth of a bacterium, along with copious amounts of water. A single bacterium will grow into a visible mound on the surface of the plate called a colony, which may be separated from other colonies or melded together into a "lawn". The size, color, shape and form of a colony is characteristic of the bacterial species, its specific genetic makeup (its strain), and the environment that supports its growth. Other ingredients are often added to the plate to aid in identification. Plates may contain substances that permit the growth of some bacteria and not others, or that change color in response to certain bacteria and not others. Bacteriological plates such as these are commonly used in the clinical identification of infectious bacterium. Microbial culture may also be used in the identification of viruses: the medium in this case being cells grown in culture that the virus can infect, and then alter or kill. In the case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic parasites may also be grown in culture as a means of identifying a particular agent. | What type of medium is provided for a specific agent in a microbial culture? | {
"text": [
"growth"
],
"answer_start": [
107
]
} |
573422a84776f4190066191f | Infection | Microbiological culture is a principal tool used to diagnose infectious disease. In a microbial culture, a growth medium is provided for a specific agent. A sample taken from potentially diseased tissue or fluid is then tested for the presence of an infectious agent able to grow within that medium. Most pathogenic bacteria are easily grown on nutrient agar, a form of solid medium that supplies carbohydrates and proteins necessary for growth of a bacterium, along with copious amounts of water. A single bacterium will grow into a visible mound on the surface of the plate called a colony, which may be separated from other colonies or melded together into a "lawn". The size, color, shape and form of a colony is characteristic of the bacterial species, its specific genetic makeup (its strain), and the environment that supports its growth. Other ingredients are often added to the plate to aid in identification. Plates may contain substances that permit the growth of some bacteria and not others, or that change color in response to certain bacteria and not others. Bacteriological plates such as these are commonly used in the clinical identification of infectious bacterium. Microbial culture may also be used in the identification of viruses: the medium in this case being cells grown in culture that the virus can infect, and then alter or kill. In the case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic parasites may also be grown in culture as a means of identifying a particular agent. | What are most pathogenic bacteria easily grown on? | {
"text": [
"nutrient agar"
],
"answer_start": [
345
]
} |
573422a84776f41900661920 | Infection | Microbiological culture is a principal tool used to diagnose infectious disease. In a microbial culture, a growth medium is provided for a specific agent. A sample taken from potentially diseased tissue or fluid is then tested for the presence of an infectious agent able to grow within that medium. Most pathogenic bacteria are easily grown on nutrient agar, a form of solid medium that supplies carbohydrates and proteins necessary for growth of a bacterium, along with copious amounts of water. A single bacterium will grow into a visible mound on the surface of the plate called a colony, which may be separated from other colonies or melded together into a "lawn". The size, color, shape and form of a colony is characteristic of the bacterial species, its specific genetic makeup (its strain), and the environment that supports its growth. Other ingredients are often added to the plate to aid in identification. Plates may contain substances that permit the growth of some bacteria and not others, or that change color in response to certain bacteria and not others. Bacteriological plates such as these are commonly used in the clinical identification of infectious bacterium. Microbial culture may also be used in the identification of viruses: the medium in this case being cells grown in culture that the virus can infect, and then alter or kill. In the case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic parasites may also be grown in culture as a means of identifying a particular agent. | What is it called when a visible mound forms on the surface of a plate? | {
"text": [
"a colony"
],
"answer_start": [
583
]
} |
573422a84776f41900661921 | Infection | Microbiological culture is a principal tool used to diagnose infectious disease. In a microbial culture, a growth medium is provided for a specific agent. A sample taken from potentially diseased tissue or fluid is then tested for the presence of an infectious agent able to grow within that medium. Most pathogenic bacteria are easily grown on nutrient agar, a form of solid medium that supplies carbohydrates and proteins necessary for growth of a bacterium, along with copious amounts of water. A single bacterium will grow into a visible mound on the surface of the plate called a colony, which may be separated from other colonies or melded together into a "lawn". The size, color, shape and form of a colony is characteristic of the bacterial species, its specific genetic makeup (its strain), and the environment that supports its growth. Other ingredients are often added to the plate to aid in identification. Plates may contain substances that permit the growth of some bacteria and not others, or that change color in response to certain bacteria and not others. Bacteriological plates such as these are commonly used in the clinical identification of infectious bacterium. Microbial culture may also be used in the identification of viruses: the medium in this case being cells grown in culture that the virus can infect, and then alter or kill. In the case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic parasites may also be grown in culture as a means of identifying a particular agent. | What is a region of dead cells resulting from viral growth called? | {
"text": [
"a \"plaque\""
],
"answer_start": [
1459
]
} |
573423284776f4190066192d | Infection | In the absence of suitable plate culture techniques, some microbes require culture within live animals. Bacteria such as Mycobacterium leprae and Treponema pallidum can be grown in animals, although serological and microscopic techniques make the use of live animals unnecessary. Viruses are also usually identified using alternatives to growth in culture or animals. Some viruses may be grown in embryonated eggs. Another useful identification method is Xenodiagnosis, or the use of a vector to support the growth of an infectious agent. Chagas disease is the most significant example, because it is difficult to directly demonstrate the presence of the causative agent, Trypanosoma cruzi in a patient, which therefore makes it difficult to definitively make a diagnosis. In this case, xenodiagnosis involves the use of the vector of the Chagas agent T. cruzi, an uninfected triatomine bug, which takes a blood meal from a person suspected of having been infected. The bug is later inspected for growth of T. cruzi within its gut. | What are live animals required by? | {
"text": [
"some microbes"
],
"answer_start": [
53
]
} |
573423284776f4190066192e | Infection | In the absence of suitable plate culture techniques, some microbes require culture within live animals. Bacteria such as Mycobacterium leprae and Treponema pallidum can be grown in animals, although serological and microscopic techniques make the use of live animals unnecessary. Viruses are also usually identified using alternatives to growth in culture or animals. Some viruses may be grown in embryonated eggs. Another useful identification method is Xenodiagnosis, or the use of a vector to support the growth of an infectious agent. Chagas disease is the most significant example, because it is difficult to directly demonstrate the presence of the causative agent, Trypanosoma cruzi in a patient, which therefore makes it difficult to definitively make a diagnosis. In this case, xenodiagnosis involves the use of the vector of the Chagas agent T. cruzi, an uninfected triatomine bug, which takes a blood meal from a person suspected of having been infected. The bug is later inspected for growth of T. cruzi within its gut. | What can Mycobacterium leprae and Treponema pallidum be grown in? | {
"text": [
"animals"
],
"answer_start": [
181
]
} |
573423284776f4190066192f | Infection | In the absence of suitable plate culture techniques, some microbes require culture within live animals. Bacteria such as Mycobacterium leprae and Treponema pallidum can be grown in animals, although serological and microscopic techniques make the use of live animals unnecessary. Viruses are also usually identified using alternatives to growth in culture or animals. Some viruses may be grown in embryonated eggs. Another useful identification method is Xenodiagnosis, or the use of a vector to support the growth of an infectious agent. Chagas disease is the most significant example, because it is difficult to directly demonstrate the presence of the causative agent, Trypanosoma cruzi in a patient, which therefore makes it difficult to definitively make a diagnosis. In this case, xenodiagnosis involves the use of the vector of the Chagas agent T. cruzi, an uninfected triatomine bug, which takes a blood meal from a person suspected of having been infected. The bug is later inspected for growth of T. cruzi within its gut. | What type of eggs may some viruses be grown in? | {
"text": [
"embryonated"
],
"answer_start": [
397
]
} |
573423294776f41900661931 | Infection | In the absence of suitable plate culture techniques, some microbes require culture within live animals. Bacteria such as Mycobacterium leprae and Treponema pallidum can be grown in animals, although serological and microscopic techniques make the use of live animals unnecessary. Viruses are also usually identified using alternatives to growth in culture or animals. Some viruses may be grown in embryonated eggs. Another useful identification method is Xenodiagnosis, or the use of a vector to support the growth of an infectious agent. Chagas disease is the most significant example, because it is difficult to directly demonstrate the presence of the causative agent, Trypanosoma cruzi in a patient, which therefore makes it difficult to definitively make a diagnosis. In this case, xenodiagnosis involves the use of the vector of the Chagas agent T. cruzi, an uninfected triatomine bug, which takes a blood meal from a person suspected of having been infected. The bug is later inspected for growth of T. cruzi within its gut. | What is it difficult to demonstrate the presence of in Chagas disease? | {
"text": [
"the causative agent"
],
"answer_start": [
651
]
} |
573423bed058e614000b69d0 | Infection | Another principal tool in the diagnosis of infectious disease is microscopy. Virtually all of the culture techniques discussed above rely, at some point, on microscopic examination for definitive identification of the infectious agent. Microscopy may be carried out with simple instruments, such as the compound light microscope, or with instruments as complex as an electron microscope. Samples obtained from patients may be viewed directly under the light microscope, and can often rapidly lead to identification. Microscopy is often also used in conjunction with biochemical staining techniques, and can be made exquisitely specific when used in combination with antibody based techniques. For example, the use of antibodies made artificially fluorescent (fluorescently labeled antibodies) can be directed to bind to and identify a specific antigens present on a pathogen. A fluorescence microscope is then used to detect fluorescently labeled antibodies bound to internalized antigens within clinical samples or cultured cells. This technique is especially useful in the diagnosis of viral diseases, where the light microscope is incapable of identifying a virus directly. | What is microscopy used for? | {
"text": [
"diagnosis of infectious disease"
],
"answer_start": [
30
]
} |
573423bed058e614000b69d1 | Infection | Another principal tool in the diagnosis of infectious disease is microscopy. Virtually all of the culture techniques discussed above rely, at some point, on microscopic examination for definitive identification of the infectious agent. Microscopy may be carried out with simple instruments, such as the compound light microscope, or with instruments as complex as an electron microscope. Samples obtained from patients may be viewed directly under the light microscope, and can often rapidly lead to identification. Microscopy is often also used in conjunction with biochemical staining techniques, and can be made exquisitely specific when used in combination with antibody based techniques. For example, the use of antibodies made artificially fluorescent (fluorescently labeled antibodies) can be directed to bind to and identify a specific antigens present on a pathogen. A fluorescence microscope is then used to detect fluorescently labeled antibodies bound to internalized antigens within clinical samples or cultured cells. This technique is especially useful in the diagnosis of viral diseases, where the light microscope is incapable of identifying a virus directly. | What do virtually all culture techniques rely on at some point? | {
"text": [
"microscopic examination"
],
"answer_start": [
157
]
} |
573423bed058e614000b69d2 | Infection | Another principal tool in the diagnosis of infectious disease is microscopy. Virtually all of the culture techniques discussed above rely, at some point, on microscopic examination for definitive identification of the infectious agent. Microscopy may be carried out with simple instruments, such as the compound light microscope, or with instruments as complex as an electron microscope. Samples obtained from patients may be viewed directly under the light microscope, and can often rapidly lead to identification. Microscopy is often also used in conjunction with biochemical staining techniques, and can be made exquisitely specific when used in combination with antibody based techniques. For example, the use of antibodies made artificially fluorescent (fluorescently labeled antibodies) can be directed to bind to and identify a specific antigens present on a pathogen. A fluorescence microscope is then used to detect fluorescently labeled antibodies bound to internalized antigens within clinical samples or cultured cells. This technique is especially useful in the diagnosis of viral diseases, where the light microscope is incapable of identifying a virus directly. | What can samples obtained from patients viewed directly under? | {
"text": [
"light microscope"
],
"answer_start": [
452
]
} |
573423bed058e614000b69d3 | Infection | Another principal tool in the diagnosis of infectious disease is microscopy. Virtually all of the culture techniques discussed above rely, at some point, on microscopic examination for definitive identification of the infectious agent. Microscopy may be carried out with simple instruments, such as the compound light microscope, or with instruments as complex as an electron microscope. Samples obtained from patients may be viewed directly under the light microscope, and can often rapidly lead to identification. Microscopy is often also used in conjunction with biochemical staining techniques, and can be made exquisitely specific when used in combination with antibody based techniques. For example, the use of antibodies made artificially fluorescent (fluorescently labeled antibodies) can be directed to bind to and identify a specific antigens present on a pathogen. A fluorescence microscope is then used to detect fluorescently labeled antibodies bound to internalized antigens within clinical samples or cultured cells. This technique is especially useful in the diagnosis of viral diseases, where the light microscope is incapable of identifying a virus directly. | When is microscopy exquisitely specific? | {
"text": [
"when used in combination with antibody based techniques."
],
"answer_start": [
636
]
} |
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