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10.1111/bcp.16006
10.1111/bcp.16006
Physiologically‐based pharmacokinetic modelling of long‐acting injectable cabotegravir and rilpivirine in pregnancy
2,025
2025-04
journal-article
Wiley
British Journal of Clinical Pharmacology
91
4
989-1002
0306-5251, 1365-2125
null
Shakir Atoyebi, Fazila Bunglawala, Nicolas Cottura, Sandra Grañana‐Castillo, Maiara Camotti Montanha, Adeniyi Olagunju, Marco Siccardi, Catriona Waitt
8
University of Liverpool Liverpool UK
25
67
true
http://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.1111/bcp.16006
null
AimsLong‐acting cabotegravir and rilpivirine have been approved to manage HIV in adults, but data regarding safe use in pregnancy are limited. Physiologically‐based pharmacokinetic (PBPK) modelling was used to simulate the approved dosing regimens in pregnancy and explore if Ctrough was maintained above cabotegravir an...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1186/s13550-023-01002-4
10.1186/s13550-023-01002-4
Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer
2,023
2023-05-31
journal-article
Springer Science and Business Media LLC
EJNMMI Research
13
1
null
2191-219X
null
Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh, Gary J. R. Cook
7
null
7
19
true
https://creativecommons.org/licenses/by/4.0
Cancer Research UK, Wellcome Trust
10.13039/501100000289, 10.13039/100010269
https://doi.org/10.1186/s13550-023-01002-4
https://link.springer.com/content/pdf/10.1186/s13550-023-01002-4.pdf
Abstract Background Immune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to treat non-small cell lung cancer (NSCLC). PD-L1 is a validated prognostic and predictive immunohistochemical biomarker of anti-PD-1/PD-L1 therapy but displays tem...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1093/braincomms/fcab072
10.1093/braincomms/fcab072
The use of simultaneous stereo-electroencephalography and magnetoencephalography in localizing the epileptogenic focus in refractory focal epilepsy
2,021
2021-04-05
journal-article
Oxford University Press (OUP)
Brain Communications
3
2
null
2632-1297
null
Umesh Vivekananda, Chunyan Cao, Wei Liu, Jing Zhang, Fergus Rugg-Gunn, Matthew C Walker, Vladimir Litvak, Bomin Sun, Shikun Zhan
9
Department of Clinical and Experimental Epilepsy, UCL, Queen Square Institute of Neurology, London WC1N 3BG, UK
13
20
true
http://creativecommons.org/licenses/by/4.0/
National Institute of Health Research, Epilepsy Research UK, Medical Research Council, Academy Medical Sciences, Wellcome Trust, National Natural Science Foundation of China
10.13039/501100000265, 10.13039/100010269, 10.13039/501100001809
https://doi.org/10.1093/braincomms/fcab072
http://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcab072/36994367/fcab072.pdf
Abstract Both magnetoencephalography and stereo-electroencephalography are used in presurgical epilepsy assessment, with contrasting advantages and limitations. It is not known whether simultaneous stereo-electroencephalography–magnetoencephalography recording confers an advantage over both individual modalities, in pa...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/v12091002
10.3390/v12091002
Defining New Pathways to Manage the Ongoing Emergence of Bat Rabies in Latin America
2,020
2020-09-08
journal-article
MDPI AG
Viruses
12
9
1002
1999-4915
null
Julio A. Benavides, William Valderrama, Sergio Recuenco, Wilson Uieda, Gerardo Suzán, Rafael Avila-Flores, Andres Velasco-Villa, Marilene Almeida, Fernanda A.G. de Andrade, Baldomero Molina-Flores, Marco Antonio Natal Vigilato, Julio Cesar Augusto Pompei, Paolo Tizzani, Jorge E. Carrera, Darcy Ibanez, Daniel G. Streick...
16
Departamento de Ecología y Biodiversidad, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370146, Chile
62
81
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.3390/v12091002
null
Rabies transmitted by common vampire bats (Desmodus rotundus) has been known since the early 1900s but continues to expand geographically and in the range of species and environments affected. In this review, we present current knowledge of the epidemiology and management of rabies in D. rotundus and argue that it can ...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1210/er.2018-00262
10.1210/er.2018-00262
Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism
2,019
2019-12-01
journal-article
The Endocrine Society
Endocrine Reviews
40
6
1605-1625
0163-769X, 1945-7189
null
Karl-Heinz Storbeck, Lina Schiffer, Elizabeth S Baranowski, Vasileios Chortis, Alessandro Prete, Lise Barnard, Lorna C Gilligan, Angela E Taylor, Jan Idkowiak, Wiebke Arlt, Cedric H L Shackleton
11
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa
130
191
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust, Wellcome Trust, Medical Research Council, Medical Research Council, Diabetes UK, Academy of Medical Sciences UK
10.13039/100010269, 10.13039/100010269, 10.13039/501100000265, 10.13039/501100000265, 10.13039/501100000361
https://doi.org/10.1210/er.2018-00262
http://academic.oup.com/edrv/advance-article-pdf/doi/10.1210/er.2018-00262/28920623/er.2018-00262.pdf
AbstractSteroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in even more detail, by the 24-hour urine steroid metabolome, which can provide unique insights into alterations of steroid flow and output indicative of underlying conditions. Mass spectrometry–based steroid metabolome profi...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1210/endocr/bqaa231
10.1210/endocr/bqaa231
11-Oxygenated Estrogens Are a Novel Class of Human Estrogens but Do not Contribute to the Circulating Estrogen Pool
2,021
2021-03-01
journal-article
The Endocrine Society
Endocrinology
162
3
null
0013-7227, 1945-7170
null
Lise Barnard, Lina Schiffer, Renate Louw du-Toit, Jennifer A Tamblyn, Shiuan Chen, Donita Africander, Wiebke Arlt, Paul A Foster, Karl-Heinz Storbeck
9
Department of Biochemistry, Stellenbosch University, Matieland, South Africa
23
32
true
http://creativecommons.org/licenses/by/4.0/
Academy of Medical Sciences, Wellcome Trust, National Research Foundation, National Institutes of Health, National Institutes of Health, University of Birmingham
10.13039/501100000691, 10.13039/100010269, 10.13039/501100001321, 10.13039/100000002, 10.13039/100000002, 10.13039/501100000855
https://doi.org/10.1210/endocr/bqaa231
http://academic.oup.com/endo/advance-article-pdf/doi/10.1210/endocr/bqaa231/35017456/bqaa231.pdf
Abstract Androgens are the obligatory precursors of estrogens. In humans, classic androgen biosynthesis yields testosterone, thought to represent the predominant circulating active androgen both in men and women. However, recent work has shown that 11-ketotestosterone, derived from the newly described 11-oxygenated and...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1002/ijc.34852
10.1002/ijc.34852
Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta‐analysis
2,024
2024-05-15
journal-article
Wiley
International Journal of Cancer
154
10
1745-1759
0020-7136, 1097-0215
null
Maartje Basten, Kuan‐Yu Pan, Lonneke A. van Tuijl, Alexander de Graeff, Joost Dekker, Adriaan W. Hoogendoorn, Femke Lamers, Adelita V. Ranchor, Roel Vermeulen, Lützen Portengen, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkam...
47
Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht The Netherlands
23
44
true
http://creativecommons.org/licenses/by/4.0/
KWF Kankerbestrijding, Medical Research Council, Wellcome Trust, National Institute on Aging, National Institute for Health and Care Research, ZonMw
10.13039/501100004622, 10.13039/501100000265, 10.13039/100010269, 10.13039/100000049, 10.13039/501100000272, 10.13039/501100001826
https://doi.org/10.1002/ijc.34852
null
AbstractDepression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two‐stage individual participant data meta...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1096/fj.202302131r
10.1096/fj.202302131r
Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess
2,024
2024-04-15
journal-article
Wiley
The FASEB Journal
38
7
null
0892-6638, 1530-6860
null
Lina Schiffer, Imken Oestlund, Jacky L. Snoep, Lorna C. Gilligan, Angela E. Taylor, Alexandra J. Sinclair, Rishi Singhal, Adrian Freeman, Ramzi Ajjan, Ana Tiganescu, Wiebke Arlt, Karl‐Heinz Storbeck
12
Institute of Metabolism and Systems Research University of Birmingham Birmingham UK
15
81
true
http://creativecommons.org/licenses/by/4.0/
National Research Foundation, National Research Foundation, National Research Foundation, Academy of Medical Sciences, Wellcome Trust, Medical Research Council
10.13039/501100001321, 10.13039/501100001321, 10.13039/501100001321, 10.13039/501100000691, 10.13039/100010269, 10.13039/501100000265
https://doi.org/10.1096/fj.202302131r
null
Abstract Aldo‐keto reductase 1C3 (AKR1C3) is a key enzyme in the activation of both classic and 11‐oxygenated androgens. In adipose tissue, AKR1C3 is co‐expressed with 11β‐hydroxysteroid dehydrogenase type 1 (HSD11B1), which catalyzes not only the local activation of glucocorticoids but also the inactivation of 11‐oxyg...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1093/gbe/evaa079
10.1093/gbe/evaa079
Loss of the Polyketide Synthase StlB Results in Stalk Cell Overproduction in Polysphondylium violaceum
2,020
2020-05-01
journal-article
Oxford University Press (OUP)
Genome Biology and Evolution
12
5
674-683
1759-6653
null
Takaaki B Narita, Yoshinori Kawabe, Koryu Kin, Richard A Gibbs, Adam Kuspa, Donna M Muzny, Stephen Richards, Joan E Strassmann, Richard Sucgang, Kim C Worley, Pauline Schaap
11
School of Life Sciences, University of Dundee, United Kingdom
14
37
true
http://creativecommons.org/licenses/by/4.0/
National Science Foundation, National Institutes of Health, Japanese Society for the Promotion of Science, Japanese Society for the Promotion of Science, European Molecular Biology Organisation, Wellcome Trust, European Research Council
10.13039/100000001, 10.13039/100000002, 10.13039/501100001691, 10.13039/501100001691, 10.13039/100004410, 10.13039/100010269, 10.13039/100010663
https://doi.org/10.1093/gbe/evaa079
http://academic.oup.com/gbe/advance-article-pdf/doi/10.1093/gbe/evaa079/33198941/evaa079.pdf
Abstract Major phenotypic innovations in social amoeba evolution occurred at the transition between the Polysphondylia and group 4 Dictyostelia, which comprise the model organism Dictyostelium discoideum, such as the formation of a new structure, the basal disk. Basal disk differentiation and robust stalk formation req...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/su10103636
10.3390/su10103636
A Comparative Analysis of Global Datasets and Initiatives for Urban Health and Sustainability
2,018
2018-10-11
journal-article
MDPI AG
Sustainability
10
10
3636
2071-1050
null
Jonathon Taylor, Andy Haines, James Milner, Mike Davies, Paul Wilkinson
5
Institute for Environmental Design and Engineering, University College London, Central House, 14 Upper Woburn Place, London WC1H 0NN, UK
6
83
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.3390/su10103636
null
Globally, urban populations are growing rapidly, and in most cases their demands for resources are beyond current limits of sustainability. Cities are therefore critical for achieving national and international sustainability objectives, such as greenhouse gas reduction. Improving sustainability may also provide opport...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1128/mbio.00614-19
10.1128/mbio.00614-19
Structure and Properties of a Natural Competence-Associated Pilin Suggest a Unique Pilus Tip-Associated DNA Receptor
2,019
2019-06-25
journal-article
American Society for Microbiology
mBio
10
3
null
2161-2129, 2150-7511
null
Mohd Zulkifli Salleh, Vijaykumar Karuppiah, Matthew Snee, Angela Thistlethwaite, Colin W. Levy, David Knight, Jeremy P. Derrick
7
Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
30
75
true
https://creativecommons.org/licenses/by/4.0/
Terengganu State Government Foundation, Wellcome Trust
10.13039/100010269
https://doi.org/10.1128/mbio.00614-19
https://journals.asm.org/doi/pdf/10.1128/mBio.00614-19
Thermus thermophilus is a thermophilic bacterium which is capable of natural transformation, the uptake of external DNA with high efficiency. DNA uptake is thought to be mediated by a competence-associated pilus, which binds the DNA substrate and mediates its transfer across the outer membrane and periplasm. Here, we d...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1038/s41598-020-74990-1
10.1038/s41598-020-74990-1
Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde
2,020
2020-10-21
journal-article
Springer Science and Business Media LLC
Scientific Reports
10
1
null
2045-2322
null
Raphael Reinbold, Tobias John, Paolo Spingardi, Akane Kawamura, Christopher J. Schofield, Richard J. Hopkinson
6
null
4
15
true
https://creativecommons.org/licenses/by/4.0
Wellcome Trust, Wellcome Trust, Wellcome Trust, Wellcome Trust, Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council, Cancer Research UK, Cancer Resea...
10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/501100000268, 10.13039/501100000268, 10.13039/501100000268, 10.13039/501100000268, 10.13039/501100000289, 10.13039/501100000289, 10.13039/501100000289, 10.13039/501100000289, 10.13039/501100000266
https://doi.org/10.1038/s41598-020-74990-1
https://www.nature.com/articles/s41598-020-74990-1.pdf
AbstractMetampicillin is a β-lactam antibiotic that is prepared by the reaction of ampicillin with formaldehyde. Although metampicillin has been studied for treatment of infections in animals and humans, its structure has been unclear. We report NMR studies revealing that metampicillin contains a formaldehyde-derived c...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.15252/emmm.201910865
10.15252/emmm.201910865
Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?
2,020
2020-10-07
journal-article
Springer Science and Business Media LLC
EMBO Molecular Medicine
12
10
null
1757-4676, 1757-4684
null
Mark Sweeney, Ben Corden, Stuart A Cook
3
null
178
360
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust, MOH | National Medical Research Council, MOH | National Medical Research Council, UKRI | Medical Research Council, British Heart Foundation, Fondation Leducq
10.13039/100010269, 10.13039/501100000274, 10.13039/501100001674
https://doi.org/10.15252/emmm.201910865
https://link.springer.com/content/pdf/10.15252/emmm.201910865.pdf
Abstract Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Irrespective of the underlying profibrotic condition (e.g. ageing, diabetes, hypertension), maladaptive cardiac fibrosis is defined by the transformation of resident fibroblasts t...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/membranes10100255
10.3390/membranes10100255
Electrophysiology Measurements of Metal Transport by MntH2 from Enterococcus faecalis
2,020
2020-09-24
journal-article
MDPI AG
Membranes
10
10
255
2077-0375
null
Matthias Gantner, Theodoros Laftsoglou, Honglin Rong, Vincent L. G. Postis, Lars J. C. Jeuken
5
School of Biomedical Sciences and the Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
0
33
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust, European Research Council
10.13039/100010269, 10.13039/501100000781
https://doi.org/10.3390/membranes10100255
null
Transition metals are essential trace elements and their high-affinity uptake is required for many organisms. Metal transporters are often characterised using metal-sensitive fluorescent dyes, limiting the metals and experimental conditions that can be studied. Here, we have tested whether metal transport by Enterococc...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/biology10101050
10.3390/biology10101050
Mitochondrial Translation Occurs Preferentially in the Peri-Nuclear Mitochondrial Network of Cultured Human Cells
2,021
2021-10-15
journal-article
MDPI AG
Biology
10
10
1050
2079-7737
null
Christin A. Albus, Rolando Berlinguer-Palmini, Caroline Hewison, Fiona McFarlane, Elisabeta-Ana Savu, Robert N. Lightowlers, Zofia M. Chrzanowska-Lightowlers, Matthew Zorkau
8
Wellcome Centre for Mitochondrial Research, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
2
34
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.3390/biology10101050
null
Human mitochondria are highly dynamic organelles, fusing and budding to maintain reticular networks throughout many cell types. Although extending to the extremities of the cell, the majority of the network is concentrated around the nucleus in most of the commonly cultured cell lines. This organelle harbours its own g...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1099/mgen.0.001307
10.1099/mgen.0.001307
Surveillance of travel-associated isolates elucidates the diversity of non-pandemic Vibrio cholerae
2,024
2024-10-16
journal-article
Microbiology Society
Microbial Genomics
10
10
null
2057-5858
null
Lia Bote, Alyce Taylor-Brown, Mailis Maes, Danielle J. Ingle, Mary Valcanis, Benjamin P. Howden, Nicholas R. Thomson
7
Wellcome Sanger Institute, Hinxton, UK
5
75
true
http://creativecommons.org/licenses/by/4.0/
Wellcome Trust, Wellcome Trust, Wellcome Trust, Wellcome Trust
10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/100010269
https://doi.org/10.1099/mgen.0.001307
null
Vibrio cholerae is a Gram-negative bacterium found in aquatic environments and is the aetiological agent of cholera, characterized by acute watery diarrhoea and severe dehydration. Cholera presents a significant global health burden of an estimated 1.3–5 million annual cases, with the current pandemic caused by a toxig...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1093/ofid/ofad488
10.1093/ofid/ofad488
The Natural History of Antibiotic-Treated Lower Limb Cellulitis: Analysis of Data Extracted From a Multicenter Clinical Trial
2,023
2023-09-30
journal-article
Oxford University Press (OUP)
Open Forum Infectious Diseases
10
10
null
2328-8957
null
O Martin Williams, Fergus Hamilton, Richard Brindle
3
UK Health Security Agency Microbiology Laboratory Services Bristol, Bristol Royal Infirmary , Bristol , UK
6
35
true
https://creativecommons.org/licenses/by/4.0/
National Institute for Health Research, Wellcome Trust
10.13039/501100000272, 10.13039/100010269
https://doi.org/10.1093/ofid/ofad488
https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad488/51801241/ofad488.pdf
Abstract Background Although cellulitis is a relatively common skin infection, there remains uncertainty about management, particularly the length and route of antimicrobials required. Further information on the symptomatology and biomarker changes associated with cellulitis over time would guide clinicians and patient...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/bs10100161
10.3390/bs10100161
Neuromodulatory Control and Language Recovery in Bilingual Aphasia: An Active Inference Approach
2,020
2020-10-21
journal-article
MDPI AG
Behavioral Sciences
10
10
161
2076-328X
null
Noor Sajid, Karl Friston, Justyna Ekert, Cathy Price, David Green
5
Wellcome Centre for Human Neuroimaging, University College London, 12 Queen Square, London WC1N 3AR, UK
13
56
true
https://creativecommons.org/licenses/by/4.0/
Medical Research Council, Wellcome Trust
10.13039/501100000265, 10.13039/100010269
https://doi.org/10.3390/bs10100161
null
Understanding the aetiology of the diverse recovery patterns in bilingual aphasia is a theoretical challenge with implications for treatment. Loss of control over intact language networks provides a parsimonious starting point that can be tested using in-silico lesions. We simulated a complex recovery pattern (alternat...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1002/msb.20145228
10.1002/msb.20145228
Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible Archean ocean
2,014
2014-04-01
journal-article
Springer Science and Business Media LLC
Molecular Systems Biology
10
4
null
1744-4292
null
Markus A Keller, Alexandra V Turchyn, Markus Ralser
3
null
225
61
true
https://creativecommons.org/licenses/by/4.0/
Isaac Newton Trust, Wellcome Trust, Royal Society, ERC, ERC
10.13039/501100004815, 10.13039/100010269, 10.13039/501100000288
https://doi.org/10.1002/msb.20145228
https://link.springer.com/content/pdf/10.1002/msb.20145228.pdf
Abstract The reaction sequences of central metabolism, glycolysis and the pentose phosphate pathway provide essential precursors for nucleic acids, amino acids and lipids. However, their evolutionary origins are not yet understood. Here, we provide evidence that their structure could have been fundamentally shaped by t...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1098/rsos.230405
10.1098/rsos.230405
Multiscale mobility patterns and the restriction of human movement
2,023
2023-10
journal-article
The Royal Society
Royal Society Open Science
10
10
null
2054-5703
null
Juni Schindler, Jonathan Clarke, Mauricio Barahona
3
Imperial College London
10
60
true
https://royalsociety.org/journals/ethics-policies/data-sharing-mining/
Engineering and Physical Sciences Research Council, Engineering and Physical Sciences Research Council, Wellcome Trust
10.13039/501100000266, 10.13039/501100000266, 10.13039/100010269
https://doi.org/10.1098/rsos.230405
https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.230405
From the perspective of human mobility, the COVID-19 pandemic constituted a natural experiment of enormous reach in space and time. Here, we analyse the inherent multiple scales of human mobility using Facebook Movement maps collected before and during the first UK lockdown. Firstly, we obtain the pre-lockdown UK mobil...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1136/bmjopen-2020-040321
10.1136/bmjopen-2020-040321
Triaging of respiratory protective equipment on the assumed risk of SARS-CoV-2 aerosol exposure in patient-facing healthcare workers delivering secondary care: a rapid review
2,020
2020-10
journal-article
BMJ
BMJ Open
10
10
e040321
2044-6055, 2044-6055
null
Prashanth Ramaraj, Jonathan Super, Ruben Doyle, Christopher Aylwin, Shehan Hettiaratchy
5
Major Trauma Centre, Imperial College Healthcare NHS Trust, London, UK
5
33
true
http://creativecommons.org/licenses/by-nc/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.1136/bmjopen-2020-040321
null
Objectives In patient-facing healthcare workers delivering secondary care, what is the evidence behind UK Government personal protective equipment (PPE) guidance on surgical masks versus respirators for SARS-CoV-2 protection? Design Two independent reviewers performed a rapid review. Appraisal was performed using Criti...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1098/rsif.2016.0133
10.1098/rsif.2016.0133
Distinct properties of semiquinone species detected at the ubiquinol oxidation Qo site of cytochrome <i>bc</i> 1 and their mechanistic implications
2,016
2016-05-31
journal-article
The Royal Society
Journal of The Royal Society Interface
13
118
null
1742-5689, 1742-5662
null
Rafał Pietras, Marcin Sarewicz, Artur Osyczka
3
null
27
69
true
http://creativecommons.org/licenses/by/4.0/
Wellcome Trust, Wellcome Trust
10.13039/100010269, 10.13039/100004440
https://doi.org/10.1098/rsif.2016.0133
https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2016.0133
Abstract The two-electron ubiquinol oxidation or ubiquinone reduction typically involves semiquinone (SQ) intermediates. Natural engineering of ubiquinone binding sites of bioenergetic enzymes secures that SQ is sufficiently stabilized, so that it does not leave the site to membranous environment before full oxidation/...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1186/s12936-022-04301-8
10.1186/s12936-022-04301-8
Severe malaria
2,022
2022-10-06
journal-article
Springer Science and Business Media LLC
Malaria Journal
21
1
null
1475-2875
null
Nicholas J. White
1
null
191
138
true
https://creativecommons.org/licenses/by/4.0
Wellcome Trust
10.13039/100010269
https://doi.org/10.1186/s12936-022-04301-8
https://link.springer.com/content/pdf/10.1186/s12936-022-04301-8.pdf
AbstractSevere malaria is a medical emergency. It is a major cause of preventable childhood death in tropical countries. Severe malaria justifies considerable global investment in malaria control and elimination yet, increasingly, international agencies, funders and policy makers are unfamiliar with it, and so it is ov...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1093/ofid/ofaa385
10.1093/ofid/ofaa385
Molecular Epidemiology of Human Rhinovirus From 1-Year Surveillance Within a School Setting in Rural Coastal Kenya
2,020
2020-10-01
journal-article
Oxford University Press (OUP)
Open Forum Infectious Diseases
7
10
null
2328-8957
null
Martha M Luka, Everlyn Kamau, Irene Adema, Patrick K Munywoki, Grieven P Otieno, Elijah Gicheru, Alex Gichuki, Nelson Kibinge, Charles N Agoti, D James Nokes
10
Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research – Coast, Kilifi, Kenya
16
46
true
http://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.1093/ofid/ofaa385
http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa385/33687378/ofaa385.pdf
Abstract Background Human rhinovirus (HRV) is the most common cause of the common cold but may also lead to more severe respiratory illness in vulnerable populations. The epidemiology and genetic diversity of HRV within a school setting have not been previously described. The objective of this study was to characterize...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1136/bmjgh-2025-019236
10.1136/bmjgh-2025-019236
Stakeholder analysis for ‘One Health’ approach to tackle antimicrobial resistance
2,025
2025-10
journal-article
BMJ
BMJ Global Health
10
10
e019236
2059-7908
null
Sanjib Adhikari, Komal Raj Rijal, Daniel M Parker, Prakash Ghimire, Phaik Yeong Cheah, Bipin Adhikari
6
Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal
7
53
true
https://creativecommons.org/licenses/by/4.0/
Global Health Bioethics Network (GHBN), UK, Wellcome Trust
10.13039/100010269
https://doi.org/10.1136/bmjgh-2025-019236
null
Antimicrobial resistance (AMR) and interventions to mitigate it are multisectoral, exhibiting super-wicked features that require intersectoral collaboration and synergy. Although AMR and mitigation strategies are pressing issues, their solutions are complex, ethically challenging, multilayered and often conflict at var...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/cells10020339
10.3390/cells10020339
Epithelial Cells and Inflammation in Pulmonary Wound Repair
2,021
2021-02-05
journal-article
MDPI AG
Cells
10
2
339
2073-4409
null
Amanda Croasdell Lucchini, Naomi N. Gachanja, Adriano G. Rossi, David A. Dorward, Christopher D. Lucas
5
University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh Bioquarter, Edinburgh EH16 4TJ, UK
70
142
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust, Wellcome Trust-University of Edinburgh Institutional Strategic Support Fund, Pathological Society Award
10.13039/100010269
https://doi.org/10.3390/cells10020339
null
Respiratory diseases are frequently characterised by epithelial injury, airway inflammation, defective tissue repair, and airway remodelling. This may occur in a subacute or chronic context, such as asthma and chronic obstructive pulmonary disease, or occur acutely as in pathogen challenge and acute respiratory distres...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1098/rsfs.2019.0098
10.1098/rsfs.2019.0098
Sleep, circadian rhythms and health
2,020
2020-06-06
journal-article
The Royal Society
Interface Focus
10
3
null
2042-8898, 2042-8901
null
Russell G. Foster
1
South Parks Road, Oxford OX1 3RE, UK
250
195
true
http://royalsocietypublishing.org/licence
Wellcome Trust, Wellcome Trust
10.13039/100010269, 10.13039/100010269
https://doi.org/10.1098/rsfs.2019.0098
https://royalsocietypublishing.org/doi/pdf/10.1098/rsfs.2019.0098
Abstract At the core of human thought, for the majority of individuals in the developed nations at least, there is the tacit assumption that as a species we are unfettered by the demands imposed by our biology and that we can do what we want, at whatever time we choose, whereas in reality every aspect of our physiology...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1242/jcs.230714
10.1242/jcs.230714
Anterior-enriched filopodia create the appearance of asymmetric membrane microdomains in polarizing <i>C. elegans</i> zygotes
2,019
2019-07-15
journal-article
The Company of Biologists
Journal of Cell Science
132
14
null
1477-9137, 0021-9533
null
Nisha Hirani, Rukshala Illukkumbura, Tom Bland, Grégoire Mathonnet, Delphine Suhner, Anne-Cecile Reymann, Nathan W. Goehring
7
The Francis Crick Institute 1 , 1 Midland Road, London NW1 1AT , UK
23
51
true
http://creativecommons.org/licenses/by/4.0
Francis Crick Institute, Cancer Research UK, Medical Research Council, Wellcome Trust, H2020 Marie Skłodowska-Curie Actions, Agence Nationale de la Recherche, LabEx, European Cooperation in Science and Technology, European Molecular Biology Organization
10.13039/100010438, 10.13039/501100000289, 10.13039/501100000265, 10.13039/100010269, 10.13039/100010665, 10.13039/501100001665, 10.13039/501100004100, 10.13039/501100000921, 10.13039/100004410
https://doi.org/10.1242/jcs.230714
https://journals.biologists.com/jcs/article-pdf/doi/10.1242/jcs.230714/3506145/jcs230714.pdf
ABSTRACT The association of molecules within membrane microdomains is critical for the intracellular organization of cells. During polarization of the C. elegans zygote, both polarity proteins and actomyosin regulators associate within dynamic membrane-associated foci. Recently, a novel class of asymmetric membrane-ass...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1192/bjo.2024.10
10.1192/bjo.2024.10
Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination
2,024
2024-03
journal-article
Royal College of Psychiatrists
BJPsych Open
10
2
null
2056-4724
null
Oisín O'Brien, Atheeshaan Arumuham, Yuya Mizuno, Luke Baxter, Maria Lobo, Sita Parmar, Stephen Jolles, Oliver D. Howes
8
null
4
12
true
http://creativecommons.org/licenses/by/4.0/
Medical Research Council, Maudsley Charity, Wellcome Trust
10.13039/501100000265, 10.13039/100012176, 10.13039/100010269
https://doi.org/10.1192/bjo.2024.10
null
Summary This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prior to receiving their first COVID-19 vaccine, blood samples wer...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1242/dmm.050238
10.1242/dmm.050238
Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in <i>Drosophila</i>
2,023
2023-10-01
journal-article
The Company of Biologists
Disease Models &amp; Mechanisms
16
10
null
1754-8403, 1754-8411
null
Akanksha Onkar, Deepashree Sheshadri, Anupama Rai, Arjit Kant Gupta, Nitin Gupta, Subramaniam Ganesh
6
Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India
12
81
true
http://creativecommons.org/licenses/by/4.0
University Grants Commission, Wellcome Trust, Indian Institute of Technology
10.13039/100010269, 10.13039/501100007488
https://doi.org/10.1242/dmm.050238
https://journals.biologists.com/dmm/article-pdf/doi/10.1242/dmm.050238/3141130/dmm050238.pdf
ABSTRACT Under normal physiological conditions, the mammalian brain contains very little glycogen, most of which is stored in astrocytes. However, the aging brain and the subareas of the brain in patients with neurodegenerative disorders tend to accumulate glycogen, the cause and significance of which remain largely un...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1073/pnas.1504162112
10.1073/pnas.1504162112
Age-related changes in working memory and the ability to ignore distraction
2,015
2015-05-19
journal-article
National Academy of Sciences
Proceedings of the National Academy of Sciences
112
20
6515-6518
0027-8424, 1091-6490
null
Fiona McNab, Peter Zeidman, Robb B. Rutledge, Peter Smittenaar, Harriet R. Brown, Rick A. Adams, Raymond J. Dolan
7
School of Psychology, University of Birmingham, Birmingham, B15 2TT, United Kingdom;
99
22
true
http://www.pnas.org/site/misc/userlicense.xhtml
The Wellcome Trust, The Wellcome Trust, The Wellcome Trust, The Brain Research Trust, The Wellcome Trust, The Wellcome Trust
10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/501100000368, 10.13039/100010269, 10.13039/100010269
https://doi.org/10.1073/pnas.1504162112
null
Significance We reveal a novel and highly significant change in how items are held in mind in healthy aging. Using smartphones, data were collected from 29,631 participants, between the ages of 18–69 y. We compare the ability to exclude distractors when items are entered into working memory (WM) (encoding distraction, ...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1136/bmjgh-2022-009472
10.1136/bmjgh-2022-009472
A framework for managing health research capacity strengthening consortia: addressing tensions and enhancing capacity outcomes
2,022
2022-10
journal-article
BMJ
BMJ Global Health
7
10
e009472
2059-7908
null
Nadia Tagoe, Justin Pulford, Sam Kinyanjui, Sassy Molyneux
4
Office of Grants and Research, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
8
79
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust, Wellcome Trust, UK government, DELTAS Africa Initiative
10.13039/100010269, 10.13039/100010269, 10.13039/100013986
https://doi.org/10.1136/bmjgh-2022-009472
null
There has been a steady increase in health research capacity strengthening (HRCS) consortia and programmes. However, their structures and management practices and the effect on the capacity strengthening outcomes have been underexamined. We conducted a case study involving three HRCS consortia where we critically exami...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/genes10100741
10.3390/genes10100741
Status of Insecticide Resistance and Its Mechanisms in Anopheles gambiae and Anopheles coluzzii Populations from Forest Settings in South Cameroon
2,019
2019-09-24
journal-article
MDPI AG
Genes
10
10
741
2073-4425
null
Roland Bamou, Nadège Sonhafouo-Chiana, Konstantinos Mavridis, Timoléon Tchuinkam, Charles S. Wondji, John Vontas, Christophe Antonio-Nkondjio
7
Vector Borne Diseases Laboratory of the Applied Biology and Ecology Research Unit (VBID-URBEA), Department of Animal Biology, Faculty of Science of the University of Dschang, Dschang P.O. Box 067, Cameroon
45
63
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust, European Union’s Horizon 2020 research and innovation programme
10.13039/100010269
https://doi.org/10.3390/genes10100741
null
A key factor affecting malaria vector control efforts in Cameroon is the rapid expansion of insecticide resistance in Anopheles gambiae s.l (An. gambiae) populations; however, mechanisms involved in insecticide resistance in forest mosquito populations are still not well documented yet. The present study was conducted ...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/brainsci10100760
10.3390/brainsci10100760
Glycyrrhizin Blocks the Detrimental Effects of HMGB1 on Cortical Neurogenesis after Traumatic Neuronal Injury
2,020
2020-10-21
journal-article
MDPI AG
Brain Sciences
10
10
760
2076-3425
null
Susruta Manivannan, Balkis Harari, Maryam Muzaffar, Omar Elalfy, Sameera Hettipathirannahelage, Zoe James, Feras Sharouf, Chloe Ormonde, Mouhamed Alsaqati, William Gray, Malik Zaben
11
Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff CF24 4HQ, UK
12
71
true
https://creativecommons.org/licenses/by/4.0/
Royal College of Surgeons of England, Wellcome Trust, Rhiannon Jade-Smith Trust
10.13039/501100000297, 10.13039/100010269
https://doi.org/10.3390/brainsci10100760
null
Despite medical advances, neurological recovery after severe traumatic brain injury (TBI) remains poor. Elevated levels of high mobility group box protein-1 (HMGB1) are associated with poor outcomes; likely via interaction with receptors for advanced-glycation-end-products (RAGE). We examined the hypothesis that HMGB1 ...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1155/2019/1907426
10.1155/2019/1907426
Serum Exosomal miRNAs Are Associated with Active Pulmonary Tuberculosis
2,019
2019-02-11
journal-article
Wiley
Disease Markers
2019
null
1-9
0278-0240, 1875-8630
null
Shamila D. Alipoor, Payam Tabarsi, Mohammad Varahram, Mehrnaz Movassaghi, Mehdi Kazempour Dizaji, Gert Folkerts, Johan Garssen, Ian M. Adcock, Esmaeil Mortaz
9
Institute of Medical Biotechnology, Molecular Medicine Department, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
63
38
true
http://creativecommons.org/licenses/by/4.0/
Iran National Science Foundation, Iran National Science Foundation, Welcome Trust, Welcome Trust
10.13039/501100003968, 10.13039/501100003968, 10.13039/100010269, 10.13039/100010269
https://doi.org/10.1155/2019/1907426
http://downloads.hindawi.com/journals/dm/2019/1907426.pdf
Introduction. Tuberculosis (TB) remains a major threat to human health. Due to the limited accuracy of the current TB diagnostic tests, it is critical to determine novel biomarkers for this disease. Circulating exosomes have been used as diagnostic biomarkers in various diseases. Objective of the Study. In this pilot s...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1210/clinem/dgaa766
10.1210/clinem/dgaa766
11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension
2,021
2021-01-01
journal-article
The Endocrine Society
The Journal of Clinical Endocrinology &amp; Metabolism
106
1
174-187
0021-972X, 1945-7197
null
Rowan S Hardy, Hannah Botfield, Keira Markey, James L Mitchell, Zerin Alimajstorovic, Connar S J Westgate, Michael Sagmeister, Rebecca J Fairclough, Ryan S Ottridge, Andreas Yiangou, Karl-Heinz H Storbeck, Angela E Taylor, Lorna C Gilligan, Wiebke Arlt, Paul M Stewart, Jeremy W Tomlinson, Susan P Mollan, Gareth G Laver...
19
Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
58
48
true
http://creativecommons.org/licenses/by/4.0/
Medical Research Council Asset Sharing Scheme, UK, Medical Research Council Asset Sharing Scheme, UK, National Institute for Health Research, Wellcome Trust, Academy of Medical Sciences UK, Versus Arthritis, National Institute for Health Research
10.13039/501100000272, 10.13039/100010269, 10.13039/501100012041, 10.13039/501100000272
https://doi.org/10.1210/clinem/dgaa766
http://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgaa766/34473970/dgaa766.pdf
Abstract Background The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) determines prereceptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic diseases, leading to the development of selective 11β-HSD1 inhibitors. We ex...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.12688/wellcomeopenres.24117.1
10.12688/wellcomeopenres.24117.1
Digital mental health interventions for adolescents and young people (10–24 years) in Africa: A protocol for a systematic review of mental health outcomes, engagement, and equity considerations
2,025
2025-07-04
journal-article
F1000 Research Ltd
Wellcome Open Research
10
null
331
2398-502X
null
Aggrey Gisiora Mokaya, Nondumiso Michelle Dlamini, Syethemba Nkosi, Mpilonhle Thembinkosi Nzuza, Thandeka Smith, Grace Nduku Wambua, Xanthe Hunt, Alan Stein, Nothando Ngwenya
9
null
3
39
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.12688/wellcomeopenres.24117.1
https://wellcomeopenresearch.org/articles/10-331/v1/pdf
Background Adolescents and young people (AYP) aged 10–24 years in Africa experience a high burden of mental health disorders but face significant barriers to accessing care, including a severe shortage of mental health professionals, stigma, and limited integration of mental health services into primary healthcare. Dig...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1136/bmjopen-2019-035045
10.1136/bmjopen-2019-035045
Prognostic models for predicting in-hospital paediatric mortality in resource-limited countries: a systematic review
2,020
2020-10
journal-article
BMJ
BMJ Open
10
10
e035045
2044-6055, 2044-6055
null
Morris Ogero, Rachel Jelagat Sarguta, Lucas Malla, Jalemba Aluvaala, Ambrose Agweyu, Mike English, Nelson Owuor Onyango, Samuel Akech
8
School of Mathematics, University of Nairobi College of Biological and Physical Sciences, Nairobi, Kenya
21
78
true
https://creativecommons.org/licenses/by/4.0/
The Wellcome Trust, The Wellcome Trust, The Wellcome Trust, The Wellcome Trust
10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/100010269
https://doi.org/10.1136/bmjopen-2019-035045
null
Objectives To identify and appraise the methodological rigour of multivariable prognostic models predicting in-hospital paediatric mortality in low-income and middle-income countries (LMICs). Design Systematic review of peer-reviewed journals. Data sources MEDLINE, CINAHL, Google Scholar and Web of Science electronic d...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1242/bio.058812
10.1242/bio.058812
The <i>Drosophila</i> orthologue of the primary ciliary dyskinesia-associated gene, <i>DNAAF3</i> , is required for axonemal dynein assembly
2,021
2021-10-15
journal-article
The Company of Biologists
Biology Open
10
10
null
2046-6390
null
Petra zur Lage, Zhiyan Xi, Jennifer Lennon, Iain Hunter, Wai Kit Chan, Alfonso Bolado Carrancio, Alex von Kriegsheim, Andrew P. Jarman
8
Centre for Discovery Brain Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK EH8 9XD, UK
12
43
true
http://creativecommons.org/licenses/by/4.0
Biotechnology and Biological Sciences Research Council, Wellcome Trust
10.13039/501100000268, 10.13039/100010269
https://doi.org/10.1242/bio.058812
http://journals.logists.com/bio/bio/article-pdf/doi/10.1242/bio.058812/2106350/bio058812.pdf
ABSTRACT Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD). Studies in Drosophila have helped to validate several PCD genes whose products are required for...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/genes10100790
10.3390/genes10100790
The G119S Acetylcholinesterase (Ace-1) Target Site Mutation Confers Carbamate Resistance in the Major Malaria Vector Anopheles gambiae from Cameroon: A Challenge for the Coming IRS Implementation
2,019
2019-10-11
journal-article
MDPI AG
Genes
10
10
790
2073-4425
null
Emmanuel Elanga-Ndille, Lynda Nouage, Cyrille Ndo, Achille Binyang, Tatiane Assatse, Daniel Nguiffo-Nguete, Doumani Djonabaye, Helen Irving, Billy Tene-Fossog, Charles S. Wondji
10
Centre for Research in Infectious Diseases (CRID), P.O. BOX 13591 Yaoundé, Cameroon
48
63
true
https://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.3390/genes10100790
null
Growing resistance is reported to carbamate insecticides in malaria vectors in Cameroon. However, the contribution of acetylcholinesterase (Ace-1) to this resistance remains uncharacterised. Here, we established that the G119S mutation is driving resistance to carbamates in Anopheles gambiae populations from Cameroon. ...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1017/s0031182023000677
10.1017/s0031182023000677
Patterns and drivers of vector-borne microparasites in a classic metapopulation
2,023
2023-09
journal-article
Cambridge University Press (CUP)
Parasitology
150
10
866-882
0031-1820, 1469-8161
null
Laura S. Mackenzie, Xavier Lambin, Emma Bryce, Claire L. Davies, Richard Hassall, Ali A. M. Shati, Chris Sutherland, Sandra E. Telfer
8
null
7
75
true
http://creativecommons.org/licenses/by/4.0/
Wellcome Trust, Wellcome Trust, Biotechnology and Biological Sciences Research Council
10.13039/100010269, 10.13039/100010269, 10.13039/501100000268
https://doi.org/10.1017/s0031182023000677
null
AbstractMany organisms live in fragmented populations, which has profound consequences on the dynamics of associated parasites. Metapopulation theory offers a canonical framework for predicting the effects of fragmentation on spatiotemporal host–parasite dynamics. However, empirical studies of parasites in classical me...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1098/rstb.2024.0339
10.1098/rstb.2024.0339
Assessment of the pharmacodynamic properties of antimalarial drugs
2,026
2026-04-30
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The Royal Society
Philosophical Transactions B
381
1949
null
0962-8436, 1471-2970
null
Nicholas John White
1
Mahidol University 1 , ,
0
107
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http://creativecommons.org/licenses/by/4.0/
Wellcome
10.13039/100010269
https://doi.org/10.1098/rstb.2024.0339
https://royalsocietypublishing.org/rstb/article-pdf/doi/10.1098/rstb.2024.0339/6135527/rstb.2024.0339.pdf
Abstract Quantifying therapeutic responses in clinical malaria is easier than for most other infections as the intraerythrocytic parasites can be counted by microscopy or estimated using quantitative PCR. In treating the blood-stage of malaria, between 107 and 1013 parasites undergo a first-order decline in densities a...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3390/antiox10071030
10.3390/antiox10071030
Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs
2,021
2021-06-25
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MDPI AG
Antioxidants
10
7
1030
2076-3921
null
Tabitha Jenkins, Jerome Gouge
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Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, UK
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133
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https://creativecommons.org/licenses/by/4.0/
Wellcome Trust
10.13039/100010269
https://doi.org/10.3390/antiox10071030
null
Reactive oxygen species (ROS) play an important role in cell proliferation and differentiation. They are also by-products of aerobic living conditions. Their inherent reactivity poses a threat for all cellular components. Cells have, therefore, evolved complex pathways to sense and maintain the redox balance. Among the...
null
en
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.3389/fmmed.2024.1345510
10.3389/fmmed.2024.1345510
Combined analysis of host IFN-γ, IL-2 and IP-10 as potential LTBI biomarkers in ESAT-6/CFP-10 stimulated blood
2,024
2024-01-26
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Frontiers Media SA
Frontiers in Molecular Medicine
4
null
null
2674-0095
null
Antony M. Rapulana, Thabo Mpotje, Omolara O. Baiyegunhi, Hlumani Ndlovu, Theresa K. Smit, Timothy D. McHugh, Mohlopheni J. Marakalala
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null
12
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https://creativecommons.org/licenses/by/4.0/
Bill and Melinda Gates Foundation, Wellcome Trust, National Research Foundation, South African Medical Research Council
10.13039/100000865, 10.13039/100010269, 10.13039/501100001321, 10.13039/501100001322
https://doi.org/10.3389/fmmed.2024.1345510
null
Background: Accurate diagnosis of latent tuberculosis infected (LTBI) individuals is important in identifying individuals at risk of developing active tuberculosis. Current diagnosis of LTBI routinely relies on the detection and measurement of immune responses using the Tuberculin Skin Test (TST) and interferon gamma r...
null
null
aTzP2pM2q0vxihgcj
8BOKWayHdxQdRkImt
10.1093/sleep/14.3.226
10.1093/sleep/14.3.226
Neuroendocrine Evaluation in Kleine-Levin Syndrome: Evidence of Reduced Doparrlinergic Tone during Periods of Hypersomnolence
1,991
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Sleep
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1550-9109
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https://doi.org/10.1093/sleep/14.3.226
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D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1373/clinchem.2005.052183
10.1373/clinchem.2005.052183
Addition of a Homologous Internal Control to a Real-Time PCR Assay for Detection of Bordetella pertussis
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Christoph Koidl, Michael Bozic, Jörg Berg, Markus Stöcher, Gerhard Mühlbauer, Egon Marth, Harald H Kessler
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Molecular Diagnostics Laboratory, Institute of Hygiene, Medical University of Graz, Graz, Austria
3
13
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https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
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D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/jeclap/lpr081
10.1093/jeclap/lpr081
For the Better: The Reform of the Finnish Competition Act
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null
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https://doi.org/10.1093/jeclap/lpr081
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10.1093/sw/19.6.659
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0
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http://academic.oup.com/sw/article-pdf/19/6/659/5242156/19-6-659.pdf
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https://doi.org/10.1093/rpd/ncq578
http://academic.oup.com/rpd/article-pdf/147/4/548/4615260/ncq578.pdf
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10.1093/nq/11-3-97
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10.1093/nq/183.1.7
10.1093/nq/183.1.7
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https://doi.org/10.1093/nq/183.1.7
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https://doi.org/10.1093/ajlh/52.2.183
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https://doi.org/10.1093/jcag/gwy009.214
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null
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https://doi.org/10.1093/oxfordjournals.aje.a118864
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10.1093/nq/s6-xii.311.469g
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1471-6941, 0029-3970
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1
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https://doi.org/10.1093/nq/s6-xii.311.469g
http://academic.oup.com/nq/article-pdf/s6-XII/311/469/20783160/469-g.pdf
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https://doi.org/10.1093/ejo/24.2.217
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Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; Resource Education Center “Center of Medical Accreditation”, St. Petersburg State University, St. Petersburg, Russian Federation
0
0
true
https://academic.oup.com/journals/pages/about_us/legal/notices
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null
https://doi.org/10.1093/eurheartj/ehy563.p4186
http://academic.oup.com/eurheartj/article-pdf/39/suppl_1/ehy563.P4186/25575650/ehy563.p4186.pdf
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https://doi.org/10.1093/ehr/xxiii.xc.407
http://academic.oup.com/ehr/article-pdf/XXIII/XC/407/9768599/407.pdf
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10.1353/jsh.2001.0037
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New York before Chinatown: Orientalism and the Shaping of American Culture, 1776-1882. By John Kuo Wei Tchen (Baltimore &amp; London: Johns Hopkins University Press, 1999. xxiv plus 385pp.)
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https://doi.org/10.1093/nq/s11-xi.273.229g
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10.1093/res/os-x.40.489
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10.1111/j.1096-3642.1878.tb01544.x
10.1111/j.1096-3642.1878.tb01544.x
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1878-10
journal-article
Oxford University Press (OUP)
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William E. Armit
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null
1
0
true
http://doi.wiley.com/10.1002/tdm_license_1
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null
https://doi.org/10.1111/j.1096-3642.1878.tb01544.x
http://academic.oup.com/zoolinnean/article-pdf/14/76/411/16722700/j.1096-3642.1878.tb01544.x.pdf
null
null
en
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.2307/1230228
10.2307/1230228
Correlation and Machine Calculation
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1926-01
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Oxford University Press (OUP)
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G. W. Forster, H. A. Wallace, George W. Snedecor
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0
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true
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null
null
https://doi.org/10.2307/1230228
http://academic.oup.com/ajae/article-pdf/8/1/141/446906/8-1-141.pdf
null
null
null
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/oxfordjournals.jjco.a039106
10.1093/oxfordjournals.jjco.a039106
Instructions to Authors
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Japanese Journal of Clinical Oncology
null
null
null
1465-3621
null
null
0
null
0
0
false
null
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null
https://doi.org/10.1093/oxfordjournals.jjco.a039106
null
null
null
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D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.2307/2675579
10.2307/2675579
Power, Politics, and Crime
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Oxford University Press (OUP)
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David Jacobs, William Chambliss
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0
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false
null
null
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https://doi.org/10.2307/2675579
null
null
null
null
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/intqhc/9.1.1
10.1093/intqhc/9.1.1
COUNTERPOINT: Can CQI Really Work in Health Care? For How Long?
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Z. STERN
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true
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http://academic.oup.com/intqhc/article-pdf/9/1/1/5051325/9-1-1.pdf
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null
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D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/cdj/8.1.50
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M. J. SHEPPERDSON
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true
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http://academic.oup.com/cdj/article-pdf/8/1/50/958504/8-1-50a.pdf
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D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/jts/os-xxxiii.1.89
10.1093/jts/os-xxxiii.1.89
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0
0
true
null
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null
https://doi.org/10.1093/jts/os-xxxiii.1.89
http://academic.oup.com/jts/article-pdf/os-XXXIII/1/89/9860951/89.pdf
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10.1093/nq/s10-viii.184.10b
10.1093/nq/s10-viii.184.10b
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null
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VEcVqPhQc82PmIivF
10.1093/nq/s6-v.123.355b
10.1093/nq/s6-v.123.355b
The British oak
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true
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https://doi.org/10.1093/nq/s6-v.123.355b
http://academic.oup.com/nq/article-pdf/s6-V/123/355/22691778/355-b.pdf
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null
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D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/mind/xviii.1.636
10.1093/mind/xviii.1.636
ARCHIV F. D. GESAMTE PSYCHOLOGIE
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null
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true
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null
null
https://doi.org/10.1093/mind/xviii.1.636
http://academic.oup.com/mind/article-pdf/XVIII/1/636/9889821/636.pdf
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null
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VEcVqPhQc82PmIivF
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http://academic.oup.com/jac/article-pdf/40/3/345/9837780/400345.pdf
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null
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D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.2307/4067484
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Stejneger on a 'Lost Species' of Murrelet On Brachyramphus Perdix (Pall.) and Its Nearest Allies Leonhard Stejneger
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null
null
null
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
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Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection
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The Ohio State University Hospitals, Columbus, OH
0
0
true
null
null
null
https://doi.org/10.1093/ajhp/48.10.2181
http://academic.oup.com/ajhp/article-pdf/48/10/2181/28466457/ajhp2181.pdf
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null
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VEcVqPhQc82PmIivF
10.1093/rpc/1996rpc45
10.1093/rpc/1996rpc45
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https://doi.org/10.1093/rpc/1996rpc45
http://academic.oup.com/rpc/article-pdf/113/2/45/6923767/1996rpc45.pdf
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null
en
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VEcVqPhQc82PmIivF
10.1093/ecco-jcc/jju027.304
10.1093/ecco-jcc/jju027.304
P187. Hearing loss in patients with Inflammatory Bowel Disease
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Oxford University Press (OUP)
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suppl 1
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null
0
null
1
0
true
null
null
null
https://doi.org/10.1093/ecco-jcc/jju027.304
http://academic.oup.com/ecco-jcc/article-pdf/9/suppl_1/S170/1352303/jju027.304.pdf
null
null
en
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.2307/2216661
10.2307/2216661
Descartes' Revision of the Cartesian Dualism
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1957-07
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Oxford University Press (OUP)
The Philosophical Quarterly
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28
249
0031-8094
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Edward G. Ballard
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null
1
0
true
null
null
null
https://doi.org/10.2307/2216661
http://academic.oup.com/pq/article-pdf/7/28/249/4384532/pq7-0249.pdf
null
null
null
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/mnras/202.1.53
10.1093/mnras/202.1.53
Spectroscopic and photometric observations of six possible Seyfert galaxies
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1983-01
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Oxford University Press (OUP)
Monthly Notices of the Royal Astronomical Society
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1
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T. D. Kinman
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10
0
true
null
null
null
https://doi.org/10.1093/mnras/202.1.53
http://academic.oup.com/mnras/article-pdf/202/1/53/18223710/mnras202-0053.pdf
null
null
en
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/sleep/zsac079.584
10.1093/sleep/zsac079.584
0587 Sleep Problems are Associated with Treatment for Anemia in the US Population
2,022
2022-05-25
journal-article
Oxford University Press (OUP)
Sleep
45
Supplement_1
A258-A258
0161-8105, 1550-9109
null
Sayani Shah, Brooke Mason, Chloe Wills, Andrew Tubbs, William Killgore, Michael Grandner
6
University of Arizona
0
0
true
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
null
null
https://doi.org/10.1093/sleep/zsac079.584
https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A258/43842806/zsac079.584.pdf
Abstract Introduction Anemia is characterized as low circulating hemoglobin and is often treated with an increase in iron consumption. Previous studies have linked anemia with Restless Legs Syndrome. Regarding other sleep disorders, Insomnia has been found to be associated with anemia in children, but the relationship ...
null
en
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/sleep/zsac079.356
10.1093/sleep/zsac079.356
0359 Clinical Performance Quality of a Precision Oral Appliance Made from Novel Medical Grade Class VI Material
2,022
2022-05-25
journal-article
Oxford University Press (OUP)
Sleep
45
Supplement_1
A162-A162
0161-8105, 1550-9109
null
Mark Murphy, Len Liptak, Sung Kim, Yoann Ojeda
4
ProSomnus Sleep Technologies
0
0
true
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
null
null
https://doi.org/10.1093/sleep/zsac079.356
https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A162/43842525/zsac079.356.pdf
Abstract Introduction Oral appliance therapy device quality is an important factor for successful, efficient treatment of Obstructive Sleep Apnea. Poor device quality, defined in this investigation as the remake rate, is costly. A previous investigation reports that 13% of oral appliance therapy devices required remake...
null
en
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/sleep/zsac079.631
10.1093/sleep/zsac079.631
0634 Symptoms of insomnia and depression among individuals with Multiple Sclerosis before and during the COVID-19 – results from a prospective longitudinal study
2,022
2022-05-25
journal-article
Oxford University Press (OUP)
Sleep
45
Supplement_1
A278-A279
0161-8105, 1550-9109
null
Dena Sadeghi-Bahmani, Youkhabeh Mohammadian, Nahid Piri, Laleh Sadeghi Bahmani, Serge Brand, Andrea Goldstein-Piekarski, Habibollah Khazaie, James Gross
8
Department of Psychology, Stanford University
0
0
true
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
null
null
https://doi.org/10.1093/sleep/zsac079.631
https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A278/43843549/zsac079.631.pdf
Abstract Introduction There is some -- but inconsistent -- evidence that sleep and psychological health have deteriorated in the general population as a result of the COVID-19-pandemic and its related social restrictions. In the present study, we investigated whether and to what extent symptoms of insomnia, depression,...
null
en
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1093/sleep/zsac079.560
10.1093/sleep/zsac079.560
0563 Association between actigraphic sleep measures and lymphocyte subsets in people with chronic HIV infection
2,022
2022-05-25
journal-article
Oxford University Press (OUP)
Sleep
45
Supplement_1
A248-A248
0161-8105, 1550-9109
null
Malvika Sharma, Priya Borker, Bernard Macatangay, Naresh Punjabi, Charles Rinaldo, Steven Wolinsky, Joshua Hyong-Jin Cho, Heather McKay, Sanjay Patel
9
University of Pittsburgh Medical Center
0
0
true
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
null
null
https://doi.org/10.1093/sleep/zsac079.560
https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A248/43842994/zsac079.560.pdf
Abstract Introduction While inadequate sleep is known to increase inflammation in immunocompetent individuals, it is unknown if poor sleep worsens inflammation in people living with HIV. The ratio of CD4+/CD8+ T cells is a readily derived measure of chronic inflammation in people living with HIV. We sought to investiga...
null
en
D8FFphHHA6QRIqEaa
VEcVqPhQc82PmIivF
10.1021/bp990294w
10.1021/bp990294w
Biotechnology Notables
2,000
2000-01
journal-article
Wiley
Biotechnology Progress
16
4
null
8756-7938, 1520-6033
null
null
0
null
0
0
true
http://onlinelibrary.wiley.com/termsAndConditions#vor
null
null
https://doi.org/10.1021/bp990294w
null
null
null
en
kv2CPwj0zrmr1Z4kl
Iig3vpOj4IXMeavMf
10.1002/btpr.5420010403
10.1002/btpr.5420010403
Biotechnology Shorts
1,985
1985-12
journal-article
Wiley
Biotechnology Progress
1
4
null
8756-7938, 1520-6033
null
null
0
null
0
0
true
http://onlinelibrary.wiley.com/termsAndConditions#vor
null
null
https://doi.org/10.1002/btpr.5420010403
null
null
null
en
kv2CPwj0zrmr1Z4kl
Iig3vpOj4IXMeavMf
10.1002/btpr.5420030312
10.1002/btpr.5420030312
Biotechnology Shorts
1,987
1987-09
journal-article
Wiley
Biotechnology Progress
3
3
null
8756-7938, 1520-6033
null
null
0
null
0
0
true
http://onlinelibrary.wiley.com/termsAndConditions#vor
null
null
https://doi.org/10.1002/btpr.5420030312
null
null
null
en
kv2CPwj0zrmr1Z4kl
Iig3vpOj4IXMeavMf
10.1002/(issn)1860-7314
10.1002/(issn)1860-7314
Biotechnology Journal
2,006
2006-03-14
journal
Wiley
null
null
null
null
1860-6768
null
null
0
null
24
0
true
null
null
null
https://doi.org/10.1002/(issn)1860-7314
null
null
null
en
kv2CPwj0zrmr1Z4kl
Iig3vpOj4IXMeavMf
10.1002/btpr.5420010303
10.1002/btpr.5420010303
Biotechnology Shorts
1,985
1985-09
journal-article
Wiley
Biotechnology Progress
1
3
null
8756-7938, 1520-6033
null
null
0
null
0
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true
http://onlinelibrary.wiley.com/termsAndConditions#vor
null
null
https://doi.org/10.1002/btpr.5420010303
null
null
null
en
kv2CPwj0zrmr1Z4kl
Iig3vpOj4IXMeavMf
10.1002/biot.201290006
10.1002/biot.201290006
Industrial Biotechnology
2,012
2012-02
journal-article
Wiley
Biotechnology Journal
7
2
null
1860-6768, 1860-7314
null
null
0
null
0
0
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http://onlinelibrary.wiley.com/termsAndConditions#vor
null
null
https://doi.org/10.1002/biot.201290006
null
AbstractCover illustrationIndustrial biotechnology. Renewable biomass can be used as a raw material for the production of various chemicals, fuels and materials in a cost‐effective manner by employing metabolically engineered high performance microorganisms. This cover art shows production of biobutanol from renewable ...
null
en
kv2CPwj0zrmr1Z4kl
Iig3vpOj4IXMeavMf