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10.1093/oncolo/oyag155 | 10.1093/oncolo/oyag155 | KRAS G12R in pancreatic cancer: why this mutation resists current inhibitor strategies | 2,026 | 2026-06-06 | journal-article | Oxford University Press (OUP) | The Oncologist | 31 | 7 | null | 1083-7159, 1549-490X | null | Kenneth A Kern | 1 | Affiliate Faculty, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , San Diego, CA 92109, | 0 | 48 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1093/oncolo/oyag155 | https://academic.oup.com/oncolo/advance-article-pdf/doi/10.1093/oncolo/oyag155/68446122/oyag155.pdf | Abstract Background Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal solid malignancies, with limited therapeutic progress despite decades of cytotoxic chemotherapy. About 90% of PDAC tumors harbor activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS), making oncogenic KRAS ... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1535-7163.targ-15-b90 | 10.1158/1535-7163.targ-15-b90 | Abstract B90: HSP90 inhibitor NVP-AUY922 sensitizes intrinsic MEK inhibitor Trametinib-resistant NSCLC cells harboring KRAS mutation | 2,015 | 2015-12-01 | journal-article | American Association for Cancer Research (AACR) | Molecular Cancer Therapeutics | 14 | 12_Supplement_2 | B90-B90 | 1535-7163, 1538-8514 | null | Dae Ho Lee, Kang-Seo Park, Bora Oh, Mi-Hee Lee, Hannah Yang | 5 | 1Univ. of Ulsan Asan Medical Ctr., Seoul, Korea, Republic of; | 0 | 0 | true | null | null | null | https://doi.org/10.1158/1535-7163.targ-15-b90 | https://aacrjournals.org/mct/article/14/12_Supplement_2/B90/232668/Abstract-B90-HSP90-inhibitor-NVP-AUY922-sensitizes | Abstract Introduction: Mutant KRAS is feature of more than 25% of non-small cell lung cancers (NSCLC) and exemplifies one of the most popular oncogenic drivers. Ras-driven tumors are often hard to cure with conventional therapies and are necessary novel treatment strategies. Experiment: Using the HSP90 inhibitor NVP-AU... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.2174/0929867329666220907161505 | 10.2174/0929867329666220907161505 | Sotorasib: First Approved <i>KRAS</i> Mutation Inhibitor for the Treatment of Non-small Cell Lung Cancer | 2,023 | 2023-03 | journal-article | Bentham Science Publishers Ltd. | Current Medicinal Chemistry | 30 | 9 | 1000-1002 | 0929-8673 | null | Surya K. De | 1 | Conju-probe, San Diego, California, USA | 5 | 20 | true | null | null | null | https://doi.org/10.2174/0929867329666220907161505 | https://www.eurekaselect.com/article/download?doi=10.2174/0929867329666220907161505 | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK | |
10.1158/2159-8290.cd-rw2023-090 | 10.1158/2159-8290.cd-rw2023-090 | A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth | 2,023 | 2023-08-04 | journal-article | American Association for Cancer Research (AACR) | Cancer Discovery | 13 | 8 | 1757-1757 | 2159-8274, 2159-8290 | null | null | 0 | null | 3 | 0 | true | null | null | null | https://doi.org/10.1158/2159-8290.cd-rw2023-090 | https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-RW2023-090/727234/A-Pan-KRAS-Inhibitor-Impedes-Common-KRAS | Abstract A pan-KRAS inhibitor is selective for the inactive state of multiple KRAS mutants, sparing other RAS isoforms. | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1093/ajcp/aqaf121.447 | 10.1093/ajcp/aqaf121.447 | 20 Beyond KRAS G12D Mutation: The Prognostic Significance of The KRAS Mutation Variants on Progression-Free Survival in Pancreatic Ductal Adenocarcinoma | 2,025 | 2025-11-01 | journal-article | Oxford University Press (OUP) | American Journal of Clinical Pathology | 164 | Supplement_1 | null | 0002-9173, 1943-7722 | null | Ahmed Younes, Haider Mejbel | 2 | Emory University School of Medicine | 0 | 0 | true | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model | null | null | https://doi.org/10.1093/ajcp/aqaf121.447 | https://academic.oup.com/ajcp/article-pdf/164/Supplement_1/aqaf121.447/65271120/aqaf121.447.pdf | Abstract Pancreatic ductal adenocarcinomas (PDACs) are aggressive neoplasms with poor outcomes. The prognostic significance of major driver gene mutation, beyond KRAS G12D, is yet to be explored. A 10-year retrospective comprehensive study of the prognostic significance of major driver genes in PDACs was conducted. Nex... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1111/joim.13057 | 10.1111/joim.13057 | Targeting Kras<sup>g12c</sup>‐mutant cancer with a mutation‐specific inhibitor | 2,020 | 2020-08 | journal-article | Wiley | Journal of Internal Medicine | 288 | 2 | 183-191 | 0954-6820, 1365-2796 | null | J. G. Christensen, P. Olson, T. Briere, C. Wiel, M. O. Bergo | 5 | From the Mirati Therapeutics, Inc. San Diego CA USA | 69 | 38 | true | http://onlinelibrary.wiley.com/termsAndConditions#vor | null | null | https://doi.org/10.1111/joim.13057 | https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjoim.13057 | AbstractThe RAS genes, which include H, N, and KRAS, comprise the most frequently mutated family of oncogenes in cancer. Mutations in KRAS – such as the G12C mutation – are found in most pancreatic, half of colorectal and a third of lung cancer cases and is thus responsible for a substantial proportion of cancer deaths... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1007/s00280-023-04545-4 | 10.1007/s00280-023-04545-4 | A phase I trial of the pan-ERBB inhibitor neratinib combined with the MEK inhibitor trametinib in patients with advanced cancer with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation | 2,023 | 2023-08 | journal-article | Springer Science and Business Media LLC | Cancer Chemotherapy and Pharmacology | 92 | 2 | 107-118 | 0344-5704, 1432-0843 | null | Sarina A. Piha-Paul, Chieh Tseng, Hai T. Tran, Meng Gao, Daniel D. Karp, Vivek Subbiah, Apostolia Maria Tsimberidou, Jitesh D. Kawedia, Siqing Fu, Shubham Pant, Timothy A. Yap, Van K. Morris, Bryan K. Kee, Mariela Blum Murphy, JoAnn Lim, Funda Meric-Bernstam | 16 | null | 7 | 42 | true | https://creativecommons.org/licenses/by/4.0 | Puma Biotechnology | 10.13039/100019402 | https://doi.org/10.1007/s00280-023-04545-4 | https://link.springer.com/content/pdf/10.1007/s00280-023-04545-4.pdf | Abstract Purpose Aberrant alterations of ERBB receptor tyrosine kinases lead to tumorigenesis. Single agent therapy targeting EGFR or HER2 has shown clinical successes, but drug resistance often develops due to aberrant or compensatory mechanisms. Herein, we sought to determine the feasibility and safety of neratinib a... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.c.7429504 | 10.1158/1078-0432.c.7429504 | Data from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.c.7429504 | null | <div>AbstractPurpose:<p>To inform prognosis, treatment response, disease biology, and <i>KRAS G12C</i> mutation heterogeneity, we conducted exploratory circulating tumor DNA (ctDNA) profiling on 134 patients with solid tumors harboring a <i>KRAS G12C</i> mutation treated with single-... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1535-7163.targ-09-c108 | 10.1158/1535-7163.targ-09-c108 | Abstract C108: A novel mitotic kinesin Eg5 inhibitor exerts the growth-inhibitory effect in cancer cells in a manner independent of induction of monoastral formation but dependent of KRAS mutation status | 2,009 | 2009-12-10 | journal-article | American Association for Cancer Research (AACR) | Molecular Cancer Therapeutics | 8 | 12_Supplement | C108-C108 | 1535-7163, 1538-8514 | null | Toshimitsu Tanaka | 1 | Shizuoka Cancer Center Research Institute, Suntou-gun, Japan. | 0 | 0 | true | null | null | null | https://doi.org/10.1158/1535-7163.targ-09-c108 | https://aacrjournals.org/mct/article/8/12_Supplement/C108/237744/Abstract-C108-A-novel-mitotic-kinesin-Eg5 | Abstract Mitotic kinesin Eg5 plays an important role in mitosis, as it is critical for proper bipolar spindle assembly. After the discovery of the first Eg5 inhibitor monastrol, a number of Eg5 inhibitors have been developed as anticancer drugs. We have previously synthesized a series of S-trityl-L-cysteine (STLC) deri... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.c.7429504.v1 | 10.1158/1078-0432.c.7429504.v1 | Data from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.c.7429504.v1 | null | <div>AbstractPurpose:<p>To inform prognosis, treatment response, disease biology, and <i>KRAS G12C</i> mutation heterogeneity, we conducted exploratory circulating tumor DNA (ctDNA) profiling on 134 patients with solid tumors harboring a <i>KRAS G12C</i> mutation treated with single-... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1200/jco.2012.30.15_suppl.e14102 | 10.1200/jco.2012.30.15_suppl.e14102 | KRAS mutation profile in Puerto Rican patients with colorectal cancer: Trends in expression of KRAS mutation in PR between April 2009 to January 2011. | 2,012 | 2012-05-20 | journal-article | American Society of Clinical Oncology (ASCO) | Journal of Clinical Oncology | 30 | 15_suppl | e14102-e14102 | 0732-183X, 1527-7755 | null | Yelitza Ruiz, Christine Miranda, Robert F. Hunter | 3 | PRHOG, Bayamon, PR | 0 | 0 | false | null | null | null | https://doi.org/10.1200/jco.2012.30.15_suppl.e14102 | null | e14102 Background: The prevalence of a mutated KRAS gene in colorectal cancer shows ethnic variation with a range between 30-48% among the Caucasian, Asian, and European populations. The purpose of this study was to define the profile of KRAS mutation in colorectal cancer patients in Puerto Rico. Methods: Between April... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1538-7445.am2022-2667 | 10.1158/1538-7445.am2022-2667 | Abstract 2667: Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation | 2,022 | 2022-06-15 | journal-article | American Association for Cancer Research (AACR) | Cancer Research | 82 | 12_Supplement | 2667-2667 | 1538-7445 | null | Irene C. Waizenegger, Hengyu Lu, Claus Thamer, Fabio Savarese, Daniel Gerlach, Dorothea Rudolph, Christopher P. Vellano, Marcelo Marotti, John Heymach, Scott Kopetz, Timothy P. Heffernan, Joseph R. Marszalek, Mark P. Petronczki, Marco H. Hofmann, Norbert Kraut | 15 | 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; | 19 | 0 | true | null | null | null | https://doi.org/10.1158/1538-7445.am2022-2667 | https://aacrjournals.org/cancerres/article/82/12_Supplement/2667/699883/Abstract-2667-Trial-in-progress-Phase-1-study-of | Abstract Inhibition of KRASG12C mediated signaling and the therapeutic impact in non-small cell lung cancer (NSCLC) whose tumors carry this mutation was demonstrated clinically by sotorasib and adagrasib leading to approval of sotorasib in KRASG12C mutant NSCLC. These encouraging data are currently changing the treatme... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926606.v1 | 10.1158/1078-0432.26926606.v1 | Supplementary Figure S3 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926606.v1 | null | <p>Supplementary Figure S3</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.21203/rs.3.rs-1675918/v1 | 10.21203/rs.3.rs-1675918/v1 | Differences in gene mutation profiles of colon cancer patients with or without a KRAS mutation | 2,022 | 2022-06-03 | posted-content | Research Square Platform LLC | null | null | null | null | null | null | Shujian Chang, Yudan Zhou, Ruirong Wu, Xiaosong Ge, Yong Pu | 5 | Affiliated Hospital of Jiangnan University | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.21203/rs.3.rs-1675918/v1 | null | Abstract RAS plays an important role in the carcinogenesis of colorectal epithelial cells, but RAS mutations are only present, at most, in approximately 50% of patients. In order to compare the gene mutation profiles of patients with or without a KRAS mutation, the clinicopathological data of 858 patients and NGS test ... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926615 | 10.1158/1078-0432.26926615 | GO42144 INVESTIGATORS AND STUDY GROUP1 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926615 | null | <p>GO42144 INVESTIGATORS AND STUDY GROUP</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926597 | 10.1158/1078-0432.26926597 | Supplementary Table S1 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926597 | null | <p>Representativeness of Study Participants</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926600 | 10.1158/1078-0432.26926600 | Supplementary Figure S5 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926600 | null | <p>Supplementary Figure S5</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926609 | 10.1158/1078-0432.26926609 | Supplementary Figure S2 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926609 | null | <p>Supplementary Figure S2</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926597.v1 | 10.1158/1078-0432.26926597.v1 | Supplementary Table S1 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926597.v1 | null | <p>Representativeness of Study Participants</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/2159-8290.cd-nb2019-092 | 10.1158/2159-8290.cd-nb2019-092 | Researchers Reveal Another KRAS Inhibitor | 2,019 | 2019-09-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Discovery | 9 | 9 | 1152-1152 | 2159-8274, 2159-8290 | null | null | 0 | null | 3 | 0 | true | null | null | null | https://doi.org/10.1158/2159-8290.cd-nb2019-092 | https://aacrjournals.org/cancerdiscovery/article-pdf/9/9/1152/1847633/1152.pdf | Abstract Researchers have developed a KRAS inhibitor, BI-2852, that inhibits ERK phosphorylation and reduces proliferation of KRAS-mutant cancer cells. A drug based on the molecule may be effective in patients who don't respond to the KRASG12C inhibitors currently in clinical trials. | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926600.v1 | 10.1158/1078-0432.26926600.v1 | Supplementary Figure S5 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926600.v1 | null | <p>Supplementary Figure S5</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926609.v1 | 10.1158/1078-0432.26926609.v1 | Supplementary Figure S2 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926609.v1 | null | <p>Supplementary Figure S2</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1538-7445.am2014-lb-209 | 10.1158/1538-7445.am2014-lb-209 | Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance | 2,014 | 2014-10-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Research | 74 | 19_Supplement | LB-209-LB-209 | 0008-5472, 1538-7445 | null | Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers | 13 | 1Department of Radiation Oncology, Mass. General Hospital, Boston, MA; | 0 | 0 | true | null | null | null | https://doi.org/10.1158/1538-7445.am2014-lb-209 | https://aacrjournals.org/cancerres/article/74/19_Supplement/LB-209/598543/Abstract-LB-209-Chromatin-condensation-in-KRAS | Abstract Non-small cell lung cancer (NSCLC) with mutations in the KRAS oncogene is generally resistant to targeted agents directed against the epidermal growth factor receptor (EGFR). Although EGFR is active in KRAS-mutant cancers its role in supporting cell survival and its potential utility as a therapeutic target ha... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926615.v1 | 10.1158/1078-0432.26926615.v1 | GO42144 INVESTIGATORS AND STUDY GROUP1 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926615.v1 | null | <p>GO42144 INVESTIGATORS AND STUDY GROUP</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926603 | 10.1158/1078-0432.26926603 | Supplementary Figure S4 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926603 | null | <p>Supplementary Figure S4</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926612 | 10.1158/1078-0432.26926612 | Supplementary Figure S1 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926612 | null | <p>Supplementary Figure S1</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926606 | 10.1158/1078-0432.26926606 | Supplementary Figure S3 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926606 | null | <p>Supplementary Figure S3</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/2159-8290.cd-nb2021-0335 | 10.1158/2159-8290.cd-nb2021-0335 | Mechanisms of KRAS Inhibitor Resistance Revealed | 2,021 | 2021-06-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Discovery | 11 | 6 | 1311-1312 | 2159-8274, 2159-8290 | null | null | 0 | null | 6 | 0 | true | null | null | null | https://doi.org/10.1158/2159-8290.cd-nb2021-0335 | https://aacrjournals.org/cancerdiscovery/article-pdf/11/6/1311/3104989/1311.pdf | Abstract A recent study revealed diverse mechanisms of acquired resistance in patients with non–small cell lung cancer or colorectal cancer who stop responding to a KRASG12C inhibitor. These patients developed secondary KRAS mutations, MAPK pathway alterations, or genomic rearrangements—and in some cases multiple resis... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1538-7445.am2025-6390 | 10.1158/1538-7445.am2025-6390 | Abstract 6390: Identification of novel pan-KRAS mutation inhibitor shows significant efficacy in pancreatic cancer with no toxicity, offering hope beyond current therapies | 2,025 | 2025-04-21 | journal-article | American Association for Cancer Research (AACR) | Cancer Research | 85 | 8_Supplement_1 | 6390-6390 | 0008-5472, 1538-7445 | null | Pinar Atalay, Asli Ture, Nermin Kahraman, Izabela Fokt, Waldemar Priebe, Erdem Buyukbingol, Bulent Ozpolat | 7 | 1Houston Methodist Research Institute, Houston, TX; | 1 | 0 | true | null | null | null | https://doi.org/10.1158/1538-7445.am2025-6390 | https://aacrjournals.org/cancerres/article/85/8_Supplement_1/6390/761122/Abstract-6390-Identification-of-novel-pan-KRAS | Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to treat, with current therapies providing a median survival of just six months. The intrinsic chemoresistance and genetic heterogeneity of PDAC tumors complicate the development of effective targeted therapies. Approximately 90% of... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926612.v1 | 10.1158/1078-0432.26926612.v1 | Supplementary Figure S1 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926612.v1 | null | <p>Supplementary Figure S1</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.26926603.v1 | 10.1158/1078-0432.26926603.v1 | Supplementary Figure S4 from Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors | 2,024 | 2024-09-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi | 15 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.26926603.v1 | null | <p>Supplementary Figure S4</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1538-7445.am2026-2441 | 10.1158/1538-7445.am2026-2441 | Abstract 2441: The myCAF and ECM landscape in KRAS-mutated cancer: Utilizing liquid biomarkers to track KRAS-induced fibrosis and KRAS inhibitor efficacy | 2,026 | 2026-04-03 | journal-article | American Association for Cancer Research (AACR) | Cancer Research | 86 | 7_Supplement | 2441-2441 | 0008-5472, 1538-7445 | null | Martin Birkmose Rasmussen, Rasmus Sund Pedersen, Nicholas Willumsen, Morten Karsdal | 4 | Nordic Bioscience, Copenhagen, Denmark. | 0 | 0 | true | null | null | null | https://doi.org/10.1158/1538-7445.am2026-2441 | https://aacrjournals.org/cancerres/article/86/7_Supplement/2441/778838/Abstract-2441-The-myCAF-and-ECM-landscape-in-KRAS | Abstract Background: KRAS-driven cancer represents ∼25% of cancers, with high rates in pancreatic cancer (PDAC), colorectal cancer (CRC), and non-small cell lung cancer (NSCLC). Mutated KRAS and TGF-β signaling activate cancer-associated fibroblasts (CAFs), creating a fibrotic extracellular matrix (ECM). The fibrotic E... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.4103/crst.crst_145_21 | 10.4103/crst.crst_145_21 | Sotorasib – an inhibitor of KRAS p.G12c mutation in advanced non-small cell carcinoma | 2,021 | 2021-07 | journal-article | Medknow | Cancer Research, Statistics, and Treatment | 4 | 3 | 524-528 | 2590-3233 | null | Amit Kumar Agrawal, Ramya Pragya, Amit Choudhary, Anuj Gupta, Kuraparthy Sambasivaiah, Bal Krishna Mishra, Satvik Khaddar, Akhil Kapoor | 8 | null | 9 | 21 | true | null | null | null | https://doi.org/10.4103/crst.crst_145_21 | null | The KRAS p.G12C mutation occurs in seen in 13% of non-small cell lung cancers (NSCLCs) and in approximately 1%–3% of colorectal and other cancers. Until the last decade, there were no approved therapies for targeting the KRAS mutation, but recently, drugs targeting the mutation have been discovered. KRAS is a small pro... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/2159-8290.cd-nb2020-098 | 10.1158/2159-8290.cd-nb2020-098 | Another KRAS Inhibitor Holds Its Own | 2,020 | 2020-12-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Discovery | 10 | 12 | OF2-OF2 | 2159-8274, 2159-8290 | null | null | 0 | null | 9 | 0 | true | null | null | null | https://doi.org/10.1158/2159-8290.cd-nb2020-098 | https://aacrjournals.org/cancerdiscovery/article/10/12/OF2/2593/Another-KRAS-Inhibitor-Holds-Its-OwnAnother-KRAS | Abstract According to the KRYSTAL-1 study, the KRASG12c inhibitor adagrasib, also known as MRTX849, is largely well tolerated and shows considerable efficacy in patients with non–small cell lung cancer harboring this mutation. The drug is also active, albeit more modestly, in colorectal cancer and several other solid t... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/2159-8290.cd-nb2021-0362 | 10.1158/2159-8290.cd-nb2021-0362 | FDA Approves First KRAS Inhibitor: Sotorasib | 2,021 | 2021-08-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Discovery | 11 | 8 | OF4-OF4 | 2159-8274, 2159-8290 | null | null | 0 | null | 39 | 0 | true | null | null | null | https://doi.org/10.1158/2159-8290.cd-nb2021-0362 | https://aacrjournals.org/cancerdiscovery/article/11/8/OF4/666268/FDA-Approves-First-KRAS-Inhibitor-SotorasibFDA | Abstract The FDA has approved the first KRAS-targeted therapy, sotorasib, for patients with previously treated non-small cell lung cancer with KRASG12C mutations. In a phase II trial, the drug yielded a median progression-free survival of 6.8 months in patients whose disease had advanced despite treatment with standard... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.31466/kfbd.981849 | 10.31466/kfbd.981849 | Comparison of KRAS Mutation Status with Clinical Parameters in Colon Adenocarcinoma | 2,021 | 2021-12-15 | journal-article | Karadeniz Fen Bilimleri Dergisi | Karadeniz Fen Bilimleri Dergisi | 11 | 2 | 648-662 | 2564-7377 | null | Barış BOYLU, Mustafa TÜRKMEN | 2 | Giresun Üniversitesi | 0 | 38 | false | null | null | null | https://doi.org/10.31466/kfbd.981849 | null | KRAS mutations are mutually exclusive with other activating mutations on EGFR pathway. Detection of KRAS mutations associated with tumorigenesis, predicates the lack of other mutations on the same pathway and shows that the application of targeted therapy approaches which target other proteins in EGFR-MAPK pathway inef... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/2159-8290.cd-nb2020-089 | 10.1158/2159-8290.cd-nb2020-089 | KRAS Inhibitor Continues to Impress in NSCLC | 2,020 | 2020-11-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Discovery | 10 | 11 | 1617-1617 | 2159-8274, 2159-8290 | null | null | 0 | null | 3 | 0 | true | null | null | null | https://doi.org/10.1158/2159-8290.cd-nb2020-089 | https://aacrjournals.org/cancerdiscovery/article-pdf/10/11/1617/1816282/1617.pdf | Abstract Evidence continues to grow that KRAS, once considered an “undruggable” target, can be targeted successfully in non–small cell lung cancer. In a phase I trial, the KRASG12C inhibitor sotorasib elicited responses in about a third of patients with the disease and was generally well tolerated. | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.26434/chemrxiv.15002376/v1 | 10.26434/chemrxiv.15002376/v1 | D33E mutation reshapes active and inactive conformations of KRAS | 2,026 | 2026-04-24 | posted-content | American Chemical Society (ACS) | null | null | null | null | null | null | Nicholas A. Carton, Maxim Mulligan, Brajesh Narayan, Nicolae-Viorel Buchete | 4 | School of Physics | 0 | 0 | true | null | null | null | https://doi.org/10.26434/chemrxiv.15002376/v1 | null | GTP-bound KRAS cycles between inactive and active conformations through coordinated rearrangements of Switch I and Switch II, yet the structural and kinetic consequences of many clinically observed mutations remain unresolved. The rare D33E substitution lies within the electrostatic network of Switch I and, despite bei... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.70389/pjs.100001 | 10.70389/pjs.100001 | Targeting the Undruggable KRAS Mutation in Lung Cancer: A Review | 2,024 | 2024-10-27 | journal-article | Premier Science | Premier Journal of Science | null | null | null | 3049-9011 | null | Clark Jones | 1 | Pharmaceutical Scientist and Molecular Biologist | 0 | 32 | true | http://creativecommons.org/licenses/by/3.0/deed.en_US | null | null | https://doi.org/10.70389/pjs.100001 | null | Targeting the KRAS mutation in lung cancer has proven to be a challenging yet essential task due to its intricate signaling mechanisms and high prevalence in non-small cell lung cancer (NSCLC). Despite historical setbacks, recent advancements have led to the approval of targeted therapies such as sotorasib and adagrasi... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.c.8630813 | 10.1158/1078-0432.c.8630813 | Data from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with <i>KRAS</i> Mutation-Positive Solid Tumors | 2,026 | 2026-08-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto | 9 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.c.8630813 | null | <div>Abstract Purpose:<p>BI 1701963 is a small-molecule son of sevenless 1 (SOS1) inhibitor that selectively binds to SOS1, blocking the protein–protein interaction of SOS1 with guanosine diphosphate-bound rat sarcoma virus (RAS) proteins [Kirsten RAS (KRAS), Harvey RAS, and neuroblastoma RAS], thereby inhi... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1101/2022.12.16.520846 | 10.1101/2022.12.16.520846 | A non-conserved histidine residue on KRAS drives paralog selectivity of the KRAS G12D inhibitor MRTX1133 | 2,022 | 2022-12-19 | posted-content | openRxiv | null | null | null | null | null | null | Miles A. Keats, John J. W. Han, Yeon-Hwa Lee, Chih-Shia Lee, Ji Luo | 5 | null | 1 | 15 | true | null | null | null | https://doi.org/10.1101/2022.12.16.520846 | null | Abstract The discovery of small molecule inhibitors against mutant KRAS protein was a recent breakthrough in targeted therapy. Understanding the mechanism of selectivity by KRAS inhibitors and the mechanism of resistance to them can guide the future development of KRAS inhibitors. MRTX1133 was the first non-covalent in... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/2159-8290.cd-rw2021-167 | 10.1158/2159-8290.cd-rw2021-167 | Resistant KRAS(G12C) Inhibitor Subclones Exhibit Heterogeneous Alterations | 2,022 | 2022-01-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Discovery | 12 | 1 | 13-13 | 2159-8274, 2159-8290 | null | null | 0 | null | 0 | 0 | true | null | null | null | https://doi.org/10.1158/2159-8290.cd-rw2021-167 | https://aacrjournals.org/cancerdiscovery/article-pdf/12/1/13/3019863/13a.pdf | Abstract KRAS(G12C) inhibitor (G12Ci) resistance exhibits a heterogeneous pattern with no one dominant alteration. | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.33143537 | 10.1158/1078-0432.33143537 | Supplementary Table S4 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with <i>KRAS</i> Mutation-Positive Solid Tumors | 2,026 | 2026-08-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto | 9 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.33143537 | null | <p>Supplementary Table S4: Pharmacokinetic parameters of BI 1701963 monotherapy (Studies NCT04111458, NCT04835714 and NCT04627142)</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.3390/cancers17071237 | 10.3390/cancers17071237 | Trends in Overall Survival in Lung Adenocarcinoma with EGFR Mutation, KRAS Mutation, or No Mutation | 2,025 | 2025-04-05 | journal-article | MDPI AG | Cancers | 17 | 7 | 1237 | 2072-6694 | null | Martin Faehling, Sabine Fallscheer, Birgit Schwenk, Harald Seifarth, Jörn Sträter, Claudia Lengerke, Petros Christopoulos | 7 | Clinic of Cardiology and Pneumology, Esslingen Hospital, 73730 Esslingen, Germany | 2 | 56 | true | https://creativecommons.org/licenses/by/4.0/ | German Cancer Consortium | 10.13039/501100012353 | https://doi.org/10.3390/cancers17071237 | null | Background: Treatment of lung adenocarcinoma has changed and now includes checkpoint inhibitors (CPIs) or, in the case of an EGFR mutation, third-generation EGFR TKI osimertinib. Few data compare the long-term overall survival (OS) of current and historic subgroups. Methods: This real-world analysis (KOMPASS study) inc... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.33143549 | 10.1158/1078-0432.33143549 | Supplementary Figure S2 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with <i>KRAS</i> Mutation-Positive Solid Tumors | 2,026 | 2026-08-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto | 9 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.33143549 | null | <p>Supplementary Figure S2. Ki67 Proliferative Index from tumor biopsies taken at screening and at Day 16 of Cycle 1 in patients treated in NCT04111458</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1538-7445.am2019-2197 | 10.1158/1538-7445.am2019-2197 | Abstract 2197: The AXL kinase inhibitor, TP-0903, demonstrates efficacy in preclinical models of colorectal cancer independent of KRAS mutation status | 2,019 | 2019-07-01 | journal-article | American Association for Cancer Research (AACR) | Cancer Research | 79 | 13_Supplement | 2197-2197 | 0008-5472, 1538-7445 | null | Ryan Mangelson, Peter Peterson, Jason M. Foulks, Yuta Matsumura, Lars Mouritsen, Clifford J. Whatcott, David J. Bearss, Steven L. Warner | 8 | Tolero Pharmaceuticals, Inc., Lehi, UT. | 3 | 0 | true | null | null | null | https://doi.org/10.1158/1538-7445.am2019-2197 | https://aacrjournals.org/cancerres/article/79/13_Supplement/2197/634210/Abstract-2197-The-AXL-kinase-inhibitor-TP-0903 | Abstract Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in the US (2017). Most patients present with stage II or III disease at diagnosis, with the 5-year survival rate between 53-89%. Survival in patients with stage IV CRC, however, is a discouraging 11%. Metastasis in CRC is linked to ... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.20944/preprints202105.0471.v1 | 10.20944/preprints202105.0471.v1 | The KRAS G12C mutation in NSCLC: from target to resistance | 2,021 | 2021-05-20 | posted-content | MDPI AG | null | null | null | null | null | null | Alfredo Addeo, Giuseppe Luigi Banna, Alex Friedlaender | 3 | null | 15 | 0 | true | http://creativecommons.org/licenses/by/4.0 | null | null | https://doi.org/10.20944/preprints202105.0471.v1 | null | Lung cancer represents the most common form of cancer accounting for 1.8 million deaths globally in 2020.The 5-year relative survival rate for lung cancer is lower than many other leading cancer types. Over the last decade the treatment for advanced and metastatic non small cell lung cancer have dramatically improved d... | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.33143552 | 10.1158/1078-0432.33143552 | Supplementary Figure S1 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with <i>KRAS</i> Mutation-Positive Solid Tumors | 2,026 | 2026-08-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto | 9 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.33143552 | null | <p>Supplementary Figure S1: Geometric mean drug plasma concentration-time profiles of BI 1701963 QD after single and multiple administrations.</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1078-0432.33143543 | 10.1158/1078-0432.33143543 | Supplementary Table S2 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with <i>KRAS</i> Mutation-Positive Solid Tumors | 2,026 | 2026-08-03 | posted-content | American Association for Cancer Research (AACR) | null | null | null | null | null | null | Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto | 9 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.1158/1078-0432.33143543 | null | <p>Supplementary Table S2: Representativeness of study participants with KRAS mutation-positive solid tumors</p> | null | null | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.1158/1557-3125.ras18-ia19 | 10.1158/1557-3125.ras18-ia19 | Abstract IA19: Insight towards therapeutic susceptibility of KRAS-mutant cancers from MRTX1257, a novel KRAS G12C mutant-selective small-molecule inhibitor | 2,020 | 2020-05-01 | journal-article | American Association for Cancer Research (AACR) | Molecular Cancer Research | 18 | 5_Supplement | IA19-IA19 | 1541-7786, 1557-3125 | null | James G. Christensen | 1 | Mirati Therapeutics, San Diego, CA. | 0 | 0 | true | null | null | null | https://doi.org/10.1158/1557-3125.ras18-ia19 | https://aacrjournals.org/mcr/article/18/5_Supplement/IA19/233844/Abstract-IA19-Insight-towards-therapeutic | Abstract The ability to effectively target mutated KRAS has remained elusive despite decades of research. By solving a highly informative set of ligand-complexed co-crystal structures coupled with iterative structure-based drug design, substituted tetrahydropyridopyrimidines were identified as selective, covalent inhib... | null | en | qo8UvdggP3AX1mbfD | gjZobmodLEvlFmgXK |
10.2139/ssrn.5205537 | 10.2139/ssrn.5205537 | Emergent Sentience in Large Language Models Emergent Sentience in Large Language Models: Transformer Architecture and the Neurological Foundations of Consciousness | 2,025 | 2025 | posted-content | Elsevier BV | null | null | null | null | null | null | Michael Rivera | 1 | null | 0 | 20 | false | null | null | null | https://doi.org/10.2139/ssrn.5205537 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.5220/0012960200004508 | 10.5220/0012960200004508 | Comparison and Analysis of Large Language Models Based on Transformer | 2,024 | 2024 | proceedings-article | SCITEPRESS - Science and Technology Publications | Proceedings of the 1st International Conference on Engineering Management, Information Technology and Intelligence | null | null | 597-602 | null | null | Yingying Chang | 1 | School of Information and Management Sciences, Henan Agricultural University, Zhengzhou, China, --- Select a Country --- | 0 | 0 | false | null | null | null | https://doi.org/10.5220/0012960200004508 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-2733-4_2 | 10.1007/979-8-8688-2733-4_2 | Inside the Transformer: Core Architectures | 2,026 | 2026 | book-chapter | Apress | Mastering Large Language Models | null | null | 33-76 | null | 9798868827327, 9798868827334 | Ajay Rawat, Vardan Pathak | 2 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-2733-4_2 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.2139/ssrn.6199178 | 10.2139/ssrn.6199178 | Security and Risk Implications of Transformer-Based Large Language Models | 2,026 | 2026 | posted-content | Elsevier BV | null | null | null | null | null | null | Sergey Saburov | 1 | null | 0 | 0 | false | null | null | null | https://doi.org/10.2139/ssrn.6199178 | null | The growing adoption of Large Language Models (LLMs) across a wide range of applications has introduced new challenges in application security, complementing traditional deterministic software approaches rather than replacing them entirely. While this transition enables advanced capabilities in automated reasoning and ... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.4018/979-8-3373-2038-0.ch005 | 10.4018/979-8-3373-2038-0.ch005 | Transformative Role of Transformer Models in Healthcare | 2,025 | 2025-08-29 | book-chapter | IGI Global Scientific Publishing | Transformative Role of Transformer Models in Healthcare | null | null | 123-160 | null | 9798337320380, 9798337320403 | Deepa Lakshmi S. | 1 | PG & Research Department of Computer Science, Dwaraka Doss Goverdhan Doss Vaishnav College, India | 0 | 0 | true | null | null | null | https://doi.org/10.4018/979-8-3373-2038-0.ch005 | null | Artificial Intelligence (AI) is a field of computer science that enables machines to learn, interpret, and make decisions like humans. In healthcare, AI is driving transformation by introducing systems that simulate human behavior and reasoning. The sector produces vast amounts of structured and unstructured data. AI t... | null | ng | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.20944/preprints202602.0680.v1 | 10.20944/preprints202602.0680.v1 | Security and Risk Implications of Transformer-Based Large Language Models | 2,026 | 2026-02-09 | posted-content | MDPI AG | null | null | null | null | null | null | Sergey Saburov | 1 | null | 0 | 0 | true | http://creativecommons.org/licenses/by/4.0 | null | null | https://doi.org/10.20944/preprints202602.0680.v1 | null | The growing adoption of Large Language Models (LLMs) across a wide range of applications has introduced new challenges in application security, complementing traditional deterministic software approaches rather than replacing them entirely. While this transition enables advanced capabilities in automated reasoning and ... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.21203/rs.3.rs-4640131/v1 | 10.21203/rs.3.rs-4640131/v1 | AI Content Self-Detection for Transformer-based large Language Models | 2,024 | 2024-07-31 | posted-content | Springer Science and Business Media LLC | null | null | null | null | null | null | Antonio Caiado, Michael Hahsler | 2 | Southern Methodist University | 2 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.21203/rs.3.rs-4640131/v1 | null | Abstract The usage of generative artificial intelligence (AI)tools based on large language models, including ChatGPT, Bard, and Claude, for text generation, has many exciting applications with the potential for phenomenal productivity gains. One issue is authorship attribution when using AI tools. This is especially im... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.36227/techrxiv.171925719.97800486/v1 | 10.36227/techrxiv.171925719.97800486/v1 | Mathematical Foundations of Hallucination in Transformer-Based Large Language Models for Improvisation | 2,024 | 2024-06-24 | posted-content | Institute of Electrical and Electronics Engineers (IEEE) | null | null | null | null | null | null | Ahmet Gundogmusler, Fatma Bayindiroglu, Mustafa Karakucukoglu | 3 | null | 1 | 0 | true | https://creativecommons.org/licenses/by-nc-sa/4.0/ | null | null | https://doi.org/10.36227/techrxiv.171925719.97800486/v1 | null | Transformer architectures have revolutionized natural language processing through their ability to handle longrange dependencies and generate contextually coherent text. Despite their impressive capabilities, these models frequently produce outputs that are not directly grounded in the input data, a phenomenon known as... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.36227/techrxiv.171865245.51607046/v1 | 10.36227/techrxiv.171865245.51607046/v1 | Mathematical Foundations of Hallucination in Transformer-Based Large Language Models for Improvisation | 2,024 | 2024-06-17 | posted-content | Institute of Electrical and Electronics Engineers (IEEE) | null | null | null | null | null | null | Ahmet Gundogmusler, Fatma Bayindiroglu, Mustafa Karakucukoglu | 3 | null | 2 | 0 | true | https://creativecommons.org/licenses/by-nc-sa/4.0/ | null | null | https://doi.org/10.36227/techrxiv.171865245.51607046/v1 | null | Transformer architectures have revolutionized natural language processing through their ability to handle longrange dependencies and generate contextually coherent text. Despite their impressive capabilities, these models frequently produce outputs that are not directly grounded in the input data, a phenomenon known as... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.36227/techrxiv.173610898.84404151/v1 | 10.36227/techrxiv.173610898.84404151/v1 | A Systematic Review on Optimization Approaches for Transformer and Large Language Models | 2,025 | 2025-01-05 | posted-content | Institute of Electrical and Electronics Engineers (IEEE) | null | null | null | null | null | null | Atefeh Hemmati, Fatemeh Bazikar, Amir Masoud Rahmani, Hossein Moosaei | 4 | Department of Computer Engineering, Science and Research Branch, Islamic Azad University | 2 | 0 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.36227/techrxiv.173610898.84404151/v1 | null | Large language models (LLMs) are deep learning (DL) algorithms that can perform a range of natural language processing (NLP) tasks. LLMs use transformer models trained using large datasets and have revolutionized NLP tasks. However, their large-scale implementation poses significant computational resources, efficiency,... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.20944/preprints202410.1348.v1 | 10.20944/preprints202410.1348.v1 | Investigating the Predominance of Large Language Models in Low-Resource Bangla Language Over Transformer Models for Hate Speech Detection: A Comparative Analysis | 2,024 | 2024-10-17 | posted-content | MDPI AG | null | null | null | null | null | null | Fatema Tuj Johora Faria, Laith H. Baniata, Sangwoo Kang | 3 | null | 3 | 0 | true | http://creativecommons.org/licenses/by/4.0 | null | null | https://doi.org/10.20944/preprints202410.1348.v1 | null | The rise of abusive language on social media is a significant threat to mental health and 1 social cohesion. For Bengali speakers, the need for effective detection is critical. However, current 2 methods fall short in addressing the massive volume of content. Improved techniques are urgently 3 needed to combat online h... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.36227/techrxiv.173337226.68077827/v1 | 10.36227/techrxiv.173337226.68077827/v1 | Contextual Pathway Reconfiguration for Efficient Multimodal Understanding in Transformer-based Large Language Models | 2,024 | 2024-12-05 | posted-content | Institute of Electrical and Electronics Engineers (IEEE) | null | null | null | null | null | null | Michael Kobrun, Jacob Fitzwilliam, Isabella Montmorency, Alexander Krajewski, Edward Sandringham | 5 | null | 0 | 0 | true | https://creativecommons.org/licenses/by-nc-sa/4.0/ | null | null | https://doi.org/10.36227/techrxiv.173337226.68077827/v1 | null | Contextual pathway reconfiguration introduces a dynamic approach to enhancing the performance and adaptability of transformer-based architectures in multimodal settings. By incorporating hierarchical gating mechanisms and auxiliary embedding layers, the proposed framework efficiently prioritizes and synthesizes informa... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.7551/mitpress/15517.003.0003 | 10.7551/mitpress/15517.003.0003 | Large Language Models | 2,025 | 2025-10-28 | book-chapter | The MIT Press | Large Language Models | null | null | 1-18 | null | 9780262383523 | null | 0 | null | 7 | 0 | true | null | null | null | https://doi.org/10.7551/mitpress/15517.003.0003 | https://direct.mit.edu/books/book/chapter-pdf/2560640/c000400_9780262383523.pdf | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1109/fllm67465.2025.11391180 | 10.1109/fllm67465.2025.11391180 | Automating Sarcasm Identification from App Reviews Using Transformer-based Language Models | 2,025 | 2025-11-25 | proceedings-article | IEEE | 2025 3rd International Conference on Foundation and Large Language Models (FLLM) | null | null | 1116-1118 | null | null | Khubaib Amjad Alam, Bisma Shahid, Muhammad Haroon, Qaisar Shafi, Momina Kamal Cheema | 5 | Al Ain University,College of Engineering,United Arab Emirates | 0 | 8 | true | https://doi.org/10.15223/policy-029 | null | null | https://doi.org/10.1109/fllm67465.2025.11391180 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-2297-1_9 | 10.1007/979-8-8688-2297-1_9 | Transformer Block and Full Transformer Model—It’s Time to Put the Puzzle Together | 2,026 | 2026 | book-chapter | Apress | Building Large Language Models from Scratch | null | null | 325-366 | null | 9798868822964, 9798868822971 | Dilyan Grigorov | 1 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-2297-1_9 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.31219/osf.io/k495f | 10.31219/osf.io/k495f | Semantic Layer Reconstruction in Large Language Models Using Multi-Level Transformer Feedback Mechanisms | 2,024 | 2024-12-05 | posted-content | Center for Open Science | null | null | null | null | null | null | Charles Welling, Beatrix Longborough, Barnaby Winterbourne, Isabella Eisenhardt | 4 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/legalcode | null | null | https://doi.org/10.31219/osf.io/k495f | null | Semantic Layer Reconstruction introduces a transformative mechanism for refining the interactions between transformer layers, leveraging recursive feedback to enhance semantic coherence across linguistic tasks. The framework incorporates a multi-level feedback mechanism that recalibrates token embeddings through bidire... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1109/iisec59749.2023.10391040 | 10.1109/iisec59749.2023.10391040 | Enhancing Text Summarization: Evaluating Transformer-Based Models and the Role of Large Language Models like ChatGPT | 2,023 | 2023-12-21 | proceedings-article | IEEE | 2023 4th International Informatics and Software Engineering Conference (IISEC) | null | null | 1-4 | null | null | Pınar Savcı, Bihter Das | 2 | Arçelik A.Ş.,Istanbul,Turkey | 4 | 16 | true | https://doi.org/10.15223/policy-029 | null | null | https://doi.org/10.1109/iisec59749.2023.10391040 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.31219/osf.io/7qbsa_v1 | 10.31219/osf.io/7qbsa_v1 | Contextual Residual Inversion in Transformer-Based Large Language Models: A Reversibility Paradigm for Studying Representational Fidelity | 2,025 | 2025-03-24 | posted-content | Center for Open Science | null | null | null | null | null | null | Daniel Arthev, Richard Abercrombie, Clive Fenwick | 3 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/legalcode | null | null | https://doi.org/10.31219/osf.io/7qbsa_v1 | null | Contextual Residual Inversion introduces a theoretical and computational approach for estimating partial reversibility of internal residual streams in transformer-based LLMs through non-invasive linear inversion operators applied to frozen inference passes. The method defines invertibility over structured prompt famili... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.22541/au.173145004.42488699/v1 | 10.22541/au.173145004.42488699/v1 | Dynamic Probabilistic Contextual Realignment in Transformer-Based Large Language Models for Semantic Consistency | 2,024 | 2024-11-12 | posted-content | Wiley | null | null | null | null | null | null | Yukito Odorico, Kousuke Hayashi, Isamu Kiryu, Kenta Yamagata, Daiki Masuda, Shohei Shinohara | 6 | null | 0 | 0 | true | https://creativecommons.org/licenses/by-nc-sa/4.0/ | null | null | https://doi.org/10.22541/au.173145004.42488699/v1 | null | The rapid evolution of artificial intelligence has led to the development of sophisticated language models capable of generating human-like text. However, maintaining semantic consistency throughout extended text generation remains a significant challenge. Introducing Dynamic Probabilistic Contextual Realignment (DPCR)... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1109/fllm63129.2024.10852494 | 10.1109/fllm63129.2024.10852494 | Enhancing Named Entity Recognition in Arabic: Leveraging Transformer-Based Models and Open Data Sources | 2,024 | 2024-11-26 | proceedings-article | IEEE | 2024 2nd International Conference on Foundation and Large Language Models (FLLM) | null | null | 357-361 | null | null | Faiza Belbachir, Assia Soukane | 2 | Laboratoire de Recherche LYRIDS,Ecole d’ingénieurs Campus de Paris (ECE),Paris,France | 2 | 0 | true | https://doi.org/10.15223/policy-029 | null | null | https://doi.org/10.1109/fllm63129.2024.10852494 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.18653/v1/2024.clinicalnlp-1.16 | 10.18653/v1/2024.clinicalnlp-1.16 | Conversational Topic Recommendation in Counseling and Psychotherapy with Decision Transformer and Large Language Models | 2,024 | 2024 | proceedings-article | Association for Computational Linguistics | Proceedings of the 6th Clinical Natural Language Processing Workshop | null | null | 196-201 | null | null | Aylin Gunal, Baihan Lin, Djallel Bouneffouf | 3 | null | 5 | 0 | false | null | null | null | https://doi.org/10.18653/v1/2024.clinicalnlp-1.16 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-2785-3_3 | 10.1007/979-8-8688-2785-3_3 | Advanced Transformer Architectures | 2,026 | 2026 | book-chapter | Apress | Transformers and Large Language Models | null | null | 123-183 | null | 9798868827846, 9798868827853 | Ahmed Fawzy Gad | 1 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-2785-3_3 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-0515-8_1 | 10.1007/979-8-8688-0515-8_1 | Introduction to Large Language Models with OpenAI | 2,024 | 2024 | book-chapter | Apress | Large Language Models Projects | null | null | 3-29 | null | 9798868805141, 9798868805158 | Pere Martra | 1 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-0515-8_1 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-2216-2_7 | 10.1007/979-8-8688-2216-2_7 | Unpacking the Transformer Architecture | 2,025 | 2025 | book-chapter | Apress | The Practical Guide to Large Language Models | null | null | 295-348 | null | 9798868822155, 9798868822162 | Ivan Gridin | 1 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-2216-2_7 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1109/i3ctcon68242.2026.11507131 | 10.1109/i3ctcon68242.2026.11507131 | Context-Aware Transformer Optimization for Improved Generalization in Large Language Models | 2,026 | 2026-03-14 | proceedings-article | IEEE | 2026 IEEE International Conference for Convergence in Computing Technology (I3CTCON) | null | null | 1-6 | null | null | Santosh Datta Bompally | 1 | Webster University,Independent Security Researcher,MO,63119 | 0 | 20 | true | https://doi.org/10.15223/policy-029 | null | null | https://doi.org/10.1109/i3ctcon68242.2026.11507131 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.3905/jfds.2025.1.198 | 10.3905/jfds.2025.1.198 | Quantitative Models with Qualitative Scenarios: Simulation with Transformer and Large Language Models | 2,025 | 2025-07-31 | journal-article | With Intelligence LLC | The Journal of Financial Data Science | 7 | 3 | 116-131 | 2640-3943 | null | Irene Aldridge, Daham Kim | 2 | null | 0 | 0 | true | null | null | null | https://doi.org/10.3905/jfds.2025.1.198 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.3390/electronics15142988 | 10.3390/electronics15142988 | Hierarchical Classification of Arabic Legal Cases Using Transformer Architectures and Large Language Models | 2,026 | 2026-07-08 | journal-article | MDPI AG | Electronics | 15 | 14 | 2988 | 2079-9292 | null | Nourah Alangari, Nouf Alshenaifi, Huda Almuzaini | 3 | Computer Science Department, College of Computer and Information Sciences, King Saud University, Riyadh 11543, Saudi Arabia | 0 | 26 | true | https://creativecommons.org/licenses/by/4.0/ | null | null | https://doi.org/10.3390/electronics15142988 | null | Automated classification of Arabic legal texts presents unique challenges stemming from the formal register of judicial language, domain-specific Sharī‘a terminology, and the severe class imbalance inherent in hierarchical legal taxonomies. This paper addresses these challenges through a systematic investigation of hie... | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-2733-4_1 | 10.1007/979-8-8688-2733-4_1 | Introduction to Large Language Models | 2,026 | 2026 | book-chapter | Apress | Mastering Large Language Models | null | null | 3-31 | null | 9798868827327, 9798868827334 | Ajay Rawat, Vardan Pathak | 2 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-2733-4_1 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.5220/0012717200003756 | 10.5220/0012717200003756 | Artificial Intelligence-Powered Large Language Transformer Models for Opioid Abuse and Social Determinants of Health Detection for the Underserved Population | 2,024 | 2024 | proceedings-article | SCITEPRESS - Science and Technology Publications | Proceedings of the 13th International Conference on Data Science, Technology and Applications | null | null | 15-26 | null | null | Don Roosan, Yanting Wu, Jay Chok, Christopher Sanine, Tiffany Khou, Yawen Li, Hasiba Khan | 7 | Western University of Health Sciences, College of Pharmacy, 309 E 2nd Street, Pomona, CA, U.S.A. | 9 | 0 | false | null | null | null | https://doi.org/10.5220/0012717200003756 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.18653/v1/2025.xllm-1.10 | 10.18653/v1/2025.xllm-1.10 | Seamlessly Integrating Tree-Based Positional Embeddings into Transformer Models for Source Code Representation | 2,025 | 2025 | proceedings-article | Association for Computational Linguistics | Proceedings of the 1st Joint Workshop on Large Language Models and Structure Modeling (XLLM 2025) | null | null | 91-98 | null | null | Patryk Bartkowiak, Filip Graliński | 2 | null | 0 | 0 | false | null | null | null | https://doi.org/10.18653/v1/2025.xllm-1.10 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/978-3-031-76646-6_26 | 10.1007/978-3-031-76646-6_26 | In the Engine Room: Transformer Models | 2,025 | 2025 | book-chapter | Springer Nature Switzerland | Synthesis Lectures on Human-Centered Informatics | null | null | 193-202 | 1946-7680, 1946-7699 | 9783031766459, 9783031766466 | Clayton Lewis | 1 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/978-3-031-76646-6_26 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-0540-0_2 | 10.1007/979-8-8688-0540-0_2 | What Are Large Language Models? | 2,024 | 2024 | book-chapter | Apress | Introduction to Python and Large Language Models | null | null | 59-100 | null | 9798868805394, 9798868805400 | Dilyan Grigorov | 1 | null | 2 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-0540-0_2 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.31219/osf.io/bj7xc_v1 | 10.31219/osf.io/bj7xc_v1 | Large Language Models with Novel Token Processing Architecture: A Study of the Dynamic Sequential Transformer | 2,024 | 2024-10-22 | posted-content | Center for Open Science | null | null | null | null | null | null | Kusi Men, Na Pin, Shumei Lu, Qian Zhang, Huanhuan Wang | 5 | null | 0 | 0 | true | https://creativecommons.org/licenses/by/4.0/legalcode | null | null | https://doi.org/10.31219/osf.io/bj7xc_v1 | null | The increasing complexity and scale of language models have introduced significant challenges related to computational efficiency, inference speed, and the generation of factually accurate responses. Addressing these issues, a novel architectural enhancement known as the Dynamic Sequential Transformer (DST) has been pr... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1201/9781003474173-5 | 10.1201/9781003474173-5 | Deep Learning Transformer Architecture | 2,024 | 2024-05-28 | book-chapter | Chapman and Hall/CRC | Artificial Intelligence and Large Language Models | null | null | 153-190 | null | 9781003474173 | Kutub Thakur, Helen G. Barker, Al-Sakib Khan Pathan | 3 | null | 0 | 0 | false | null | null | null | https://doi.org/10.1201/9781003474173-5 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.2139/ssrn.5175593 | 10.2139/ssrn.5175593 | Construction of Collaborative Intelligent Manufacturing Agents For Special Transformer Coil Workshop Based on Large Language Models And Digital Twins | 2,025 | 2025 | posted-content | Elsevier BV | null | null | null | null | null | null | Xuedong Zhang, Wenlei Sun, Ke Chen, Renben Jiang | 4 | null | 0 | 0 | false | null | null | null | https://doi.org/10.2139/ssrn.5175593 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.5220/0014649700004058 | 10.5220/0014649700004058 | Large Language Models for Quality Control of Large Language Models | 2,026 | 2026 | proceedings-article | SCITEPRESS - Science and Technology Publications | Proceedings of the 14th International Conference on Model-Based Software and Systems Engineering | null | null | 150-161 | null | null | Preethika Chandrasekaran, Imron Shajahan, Saran Sankaran, Benjamin Nast, Kurt Sandkuhl | 5 | Institute of Computer Science, University of Rostock, Albert-Einstein-Str. 22, 18059 Rostock, Germany | 0 | 0 | false | null | null | null | https://doi.org/10.5220/0014649700004058 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1109/acet67282.2025.11430384 | 10.1109/acet67282.2025.11430384 | On the Interpretability of Transformer Based Large Language Models | 2,025 | 2025-11-21 | proceedings-article | IEEE | 2025 2nd International Conference on Advanced Computing and Emerging Technologies (ACET) | null | null | 1-6 | null | null | Aarush Sharma, Lavika Goel, VK Panchal | 3 | Meerut institute of engineering and technology,Computer Science and Engineering,Meerut,India | 0 | 10 | true | https://doi.org/10.15223/policy-029 | null | null | https://doi.org/10.1109/acet67282.2025.11430384 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1038/s41598-026-43507-7 | 10.1038/s41598-026-43507-7 | Transparent AI for mathematics: transformer-based large language models for mathematical entity relationship extraction with XAI | 2,026 | 2026-03-11 | journal-article | Springer Science and Business Media LLC | Scientific Reports | 16 | 1 | null | 2045-2322 | null | Tanjim Taharat Aurpa | 1 | null | 0 | 35 | true | https://creativecommons.org/licenses/by-nc-nd/4.0 | null | null | https://doi.org/10.1038/s41598-026-43507-7 | https://www.nature.com/articles/s41598-026-43507-7.pdf | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1201/9781003517245-3 | 10.1201/9781003517245-3 | Large Language Models | 2,024 | 2024-08-20 | book-chapter | CRC Press | Large Language Models | null | null | 70-108 | null | 9781003517245 | John Atkinson-Abutridy | 1 | null | 0 | 0 | false | null | null | null | https://doi.org/10.1201/9781003517245-3 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1101/2025.01.28.635344 | 10.1101/2025.01.28.635344 | Database-Augmented Transformer-Based Large Language Models Achieve High Accuracy in Mapping Gene-Phenotype Relationships | 2,025 | 2025-02-01 | posted-content | openRxiv | null | null | null | null | null | null | Nicolas Matthew Suhardi, Anastasia Oktarina, Mathias P.G. Bostrom, Xu Yang, Vincentius Jeremy Suhardi | 5 | Skeletal Health and Orthopedic Research Program, Hospital for Special Surgery, New York, NY 10021, USA | 0 | 26 | true | https://www.biorxiv.org/about/FAQ#license | null | null | https://doi.org/10.1101/2025.01.28.635344 | null | Abstract Transformer-based large language models (LLMs) have demonstrated significant potential in the biological and medical fields due to their ability to effectively learn from large-scale, diverse datasets and perform a wide range of downstream tasks. However, LLMs are limited by issues such as information processi... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.2139/ssrn.5149339 | 10.2139/ssrn.5149339 | The Mathematics of Large Language Diffusion Models versus Large Language Autoregressive Models | 2,025 | 2025 | posted-content | Elsevier BV | null | null | null | null | null | null | Miquel Noguer I Alonso | 1 | null | 0 | 0 | false | null | null | null | https://doi.org/10.2139/ssrn.5149339 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-0515-8_4 | 10.1007/979-8-8688-0515-8_4 | Evaluating Models | 2,024 | 2024 | book-chapter | Apress | Large Language Models Projects | null | null | 133-190 | null | 9798868805141, 9798868805158 | Pere Martra | 1 | null | 0 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-0515-8_4 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-0515-8 | 10.1007/979-8-8688-0515-8 | Large Language Models Projects | 2,024 | 2024 | book | Apress | null | null | null | null | null | 9798868805141, 9798868805158 | Pere Martra | 1 | null | 2 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-0515-8 | https://link.springer.com/content/pdf/10.1007/979-8-8688-0515-8.pdf | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.36548/jiip.2025.2.005 | 10.36548/jiip.2025.2.005 | Improving Narrative Coherence in Dense Video Captioning through Transformer and Large Language Models | 2,025 | 2025-06-03 | journal-article | Inventive Research Organization | Journal of Innovative Image Processing | 7 | 2 | 333-361 | 2582-4252 | null | Dvijesh Bhatt, Priyank Thakkar | 2 | Department of Computer Science and Engineering, Institute of Technology, Nirma University, Ahmedabad | 3 | 53 | true | null | null | null | https://doi.org/10.36548/jiip.2025.2.005 | https://irojournals.com/iroiip/article/download/783/696 | Dense video captioning aims to identify events within a video and generate natural language descriptions for each event. Most existing approaches adhere to a two-stage framework consisting of an event proposal module and a caption generation module. Previous methodologies have predominantly employed convolutional neura... | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/979-8-8688-0540-0_1 | 10.1007/979-8-8688-0540-0_1 | Evolution and Significance of Large Language Models | 2,024 | 2024 | book-chapter | Apress | Introduction to Python and Large Language Models | null | null | 1-57 | null | 9798868805394, 9798868805400 | Dilyan Grigorov | 1 | null | 1 | 0 | true | https://www.springernature.com/gp/researchers/text-and-data-mining | null | null | https://doi.org/10.1007/979-8-8688-0540-0_1 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1109/isscc49657.2024.10454330 | 10.1109/isscc49657.2024.10454330 | 20.5 C-Transformer: A 2.6-18.1μJ/Token Homogeneous DNN-Transformer/Spiking-Transformer Processor with Big-Little Network and Implicit Weight Generation for Large Language Models | 2,024 | 2024-02-18 | proceedings-article | IEEE | 2024 IEEE International Solid-State Circuits Conference (ISSCC) | null | null | 368-370 | null | null | Sangyeob Kim, Sangjin Kim, Wooyoung Jo, Soyeon Kim, Seongyon Hong, Hoi-Jun Yoo | 6 | Korea Advanced Institute of Science and Technology,Daejeon,Korea | 39 | 9 | true | https://doi.org/10.15223/policy-029 | null | null | https://doi.org/10.1109/isscc49657.2024.10454330 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1145/3644116.3644226 | 10.1145/3644116.3644226 | Research and Application of Large Language Models in HealthcareCurrent Development of Large Language Models in the Healthcare FieldA Framework for Applying Large Language Models and the Opportunities and Challenges of Large Language Models in Healthcare: A Framework for Applying Large Language Models and the Opportunit... | 2,023 | 2023-10-20 | proceedings-article | ACM | Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science | null | null | 664-670 | null | null | Chunfang Zhou, Qingyue Gong, Jinyang Zhu, Huidan Luan | 4 | School of Artificial Intelligence and Information Technology, Nanjing University of Chinese Medicine, China | 1 | 45 | true | https://www.acm.org/publications/policies/copyright_policy#Background | null | null | https://doi.org/10.1145/3644116.3644226 | null | null | null | null | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1007/978-981-95-1050-4_18 | 10.1007/978-981-95-1050-4_18 | Symbolic Constraint-Solving Capabilities of Transformer Large Language Models | 2,026 | 2026 | book-chapter | Springer Nature Singapore | Proceedings of 1st GENZERO Workshop | null | null | 147-154 | null | 9789819510498, 9789819510504 | Leyan Pan, Chris Esposo, Jacob Abernethy, Vijay Ganesh, Wenke Lee | 5 | null | 0 | 5 | true | https://creativecommons.org/licenses/by/4.0 | Technology Innovation Institute (TII) - Abu Dhabi | null | https://doi.org/10.1007/978-981-95-1050-4_18 | null | Abstract The empirical success of Transformer-based Large Language Models (LLMs) has elicited significant interest in their application for security domains such as formal verification and program analysis. However, their application in formal domains, such as formal verification and program analysis, is constrained by... | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1201/9781003669012-4 | 10.1201/9781003669012-4 | Large Language Models in Chemistry | 2,025 | 2025-12-18 | book-chapter | CRC Press | Large Language Models for Chemists | null | null | 49-67 | null | 9781003669012 | Zhiling Zheng | 1 | null | 0 | 0 | false | null | null | null | https://doi.org/10.1201/9781003669012-4 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
10.1201/9781003595533-3 | 10.1201/9781003595533-3 | Large Language Models | 2,025 | 2025-02-27 | book-chapter | Chapman and Hall/CRC | Concept Drift in Large Language Models | null | null | 14-22 | null | 9781003595533 | Ketan Sanjay Desale | 1 | null | 0 | 0 | false | null | null | null | https://doi.org/10.1201/9781003595533-3 | null | null | null | en | sXpd57pG3k5WBybtZ | qfe2K10al8pHlHiyK |
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