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42536635 | 10.1371/journal.pone.0355172 | Incremental diagnostic yield of bone scintigraphy after standard radiologic imaging in patients with fall trauma at a Level I trauma center | This study aimed to evaluate the incremental diagnostic yield of bone scintigraphy (BS) performed after standard radiologic imaging (SRI) modalities, including radiography, computed tomography, and magnetic resonance imaging, in patients with fall trauma presenting to a Level I trauma center. Three hundred eight patien... | PLoS One | PloS one | 2026 | 2,026 | [
"Lee SJ",
"An YS",
"Yoon JK",
"Park BN",
"Park YJ"
] | Lee SJ | Park YJ | [
"Humans",
"Female",
"Accidental Falls",
"Trauma Centers",
"Male",
"Retrospective Studies",
"Radionuclide Imaging",
"Bone and Bones",
"Middle Aged",
"Adult",
"Tomography, X-Ray Computed",
"Aged",
"Magnetic Resonance Imaging"
] | [
"Journal Article"
] | 21 | 7 | e0355172 | pmc-id: PMC13426956; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536635/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536634 | 10.1371/journal.pone.0355041 | Fecal carriage of ESBL and Carbapenemase-producing Enterobacteriaceae, and its associated factors among hospital and non-hospital janitors at the University of Gondar, Northwest Ethiopia: A comparative cross-sectional study | Extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing Enterobacteriaceae (CPE) pose a critical public health threat. Janitors are routinely exposed to contaminated environments and may act as a reservoir for these resistant bacteria, particularly in resource-limited settings like Ethiopia, where data on t... | PLoS One | PloS one | 2026 | 2,026 | [
"Zayede A",
"Wondimeneh Y",
"Biset S",
"Gizachew M"
] | Zayede A | Gizachew M | [
"Ethiopia",
"Cross-Sectional Studies",
"Humans",
"beta-Lactamases",
"Feces",
"Carbapenem-Resistant Enterobacteriaceae",
"Enterobacteriaceae",
"Enterobacteriaceae Infections",
"Bacterial Proteins",
"Male",
"Female",
"Adult",
"Anti-Bacterial Agents",
"Microbial Sensitivity Tests"
] | [
"Journal Article",
"Comparative Study"
] | 21 | 7 | e0355041 | pmc-id: PMC13426960; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536634/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536633 | 10.1371/journal.pone.0354982 | In vitro and in vivo antibacterial activities and phytochemical screening of 80% methanol extract from Ehretia cymosa leaves | Antibiotic resistance has emerged as one of the most urgent global health threats, undermining the effective treatment of bacterial infections. In response, scientific interest is increasingly focused on identifying natural and effective antimicrobial agents derived from medicinal plants. In Ethiopia, Ehretia cymosa (E... | PLoS One | PloS one | 2026 | 2,026 | [
"Mekonnen E",
"Edessa D",
"Weldegebreal F",
"Aklog A",
"Gashaw T"
] | Mekonnen E | Gashaw T | [
"Plant Leaves",
"Anti-Bacterial Agents",
"Plant Extracts",
"Animals",
"Methanol",
"Mice",
"Microbial Sensitivity Tests",
"Phytochemicals"
] | [
"Journal Article"
] | 21 | 7 | e0354982 | pmc-id: PMC13427015; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536633/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536631 | 10.1371/journal.pone.0353728 | Ensemble learning-based online sequential pre-interference extreme learning for concept drifting and class imbalanced data streams | With the rapid development of data-driven technologies, real-time data streams not only exhibit concept drift but are also frequently accompanied by class imbalance problems. To address these challenges, this paper proposes an online sequential pre-interference layer extreme learning machine (OS-PIELM). The proposed mo... | PLoS One | PloS one | 2026 | 2,026 | [
"Huang Y",
"Wen H",
"Tang Q",
"Liu H"
] | Huang Y | Liu H | [
"Extreme Learning Machines",
"Ensemble Learning",
"Classification Algorithms",
"Algorithms",
"Soft Computing"
] | [
"Journal Article"
] | 21 | 7 | e0353728 | pmc-id: PMC13426951; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536631/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536630 | 10.1371/journal.pone.0354914 | A multiplex dual-probe RT-LAMP assay for rapid subtype-specific detection of respiratory syncytial virus A and B | Respiratory syncytial virus (RSV) is a leading cause of acute respiratory tract infections, particularly in infants, older adults, and immunocompromised individuals. RSV is classified into two major subtypes, RSV A and RSV B, which co-circulate seasonally and exhibit genetic variability, highlighting the need for rapid... | PLoS One | PloS one | 2026 | 2,026 | [
"Lim MS",
"Park C",
"Lee E",
"Ko SY",
"Jang WS"
] | Lim MS | Jang WS | [
"Humans",
"Nucleic Acid Amplification Techniques",
"Respiratory Syncytial Virus Infections",
"Respiratory Syncytial Virus, Human",
"Sensitivity and Specificity",
"Molecular Diagnostic Techniques",
"Rapid Diagnostic Tests",
"RNA, Viral"
] | [
"Journal Article"
] | 21 | 7 | e0354914 | pmc-id: PMC13426929; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536630/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536629 | 10.1371/journal.pone.0355046 | Herbal medicine use disclosure, database-flagged potential herb-drug interactions, and inter - interaction database concordance among patients with non-communicable diseases in Vietnam: A multicenter cross-sectional study | The widespread use of herbal medicines in clinical practice, particularly in Southeast Asia, presents significant challenges for medication safety management, notably regarding interactions between herbs and conventional drugs. Current drug interaction screening tools demonstrate substantial gaps in documenting herb-dr... | PLoS One | PloS one | 2026 | 2,026 | [
"Phan ADT",
"Vo TH",
"Luu TNN",
"Ngo HTT",
"Heinrich M",
"Kongkaew C"
] | Phan ADT | Kongkaew C | [
"Herb-Drug Interactions",
"Humans",
"Vietnam",
"Cross-Sectional Studies",
"Noncommunicable Diseases",
"Female",
"Databases, Factual",
"Middle Aged",
"Herbal Medicine",
"Plants, Medicinal",
"Adult",
"Aged",
"Disclosure"
] | [
"Journal Article",
"Multicenter Study",
"Observational Study"
] | 21 | 7 | e0355046 | pmc-id: PMC13426966; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536629/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536628 | 10.1371/journal.pone.0352856 | Barriers and levers to using an app for motor function assessment by therapists in hospitals: A qualitative study of the MFM-Play app | The Motor Function Measure (MFM) is an important evaluation tool used to monitor the progression of most neuromuscular diseases. However, the MFM is subject to inter-rater variability, and patients must produce their best effort, which can be difficult for children. In response to these issues, we developed a digital a... | PLoS One | PloS one | 2026 | 2,026 | [
"Vincent-Genod D",
"Verroul M",
"Rippert P",
"Tachibana S",
"Vuillerot C",
"MFM-Play Study Group"
] | Vincent-Genod D | Vuillerot C | [
"Humans",
"Mobile Applications",
"Qualitative Research",
"Focus Groups",
"Female",
"Male",
"Hospitals",
"Physical Therapists",
"Neuromuscular Diseases",
"Adult"
] | [
"Journal Article"
] | 21 | 7 | e0352856 | pmc-id: PMC13426978; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536628/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536627 | 10.1371/journal.pone.0354232 | Cognitive-behavioral therapy focused on inhibitory learning, for adults with avoidant/restrictive food intake disorder (ARFID): Study protocol of a prospective study | Currently, there are no evidence-based treatments available for adults with avoidant/restrictive food intake disorder (ARFID). The present paper describes the design of a study evaluating a cognitive-behavioral therapy (CBT) protocol for adults with ARFID, with a focus on exposure using inhibitory learning principles. ... | PLoS One | PloS one | 2026 | 2,026 | [
"Masereel M",
"Cardona Cano S",
"Tran TD",
"de Jonge M",
"Dumont E",
"van Elburg AA",
"Mulkens S"
] | Masereel M | Mulkens S | [
"Humans",
"Cognitive Behavioral Therapy",
"Prospective Studies",
"Adult",
"Female",
"Male",
"Treatment Outcome",
"Netherlands",
"Avoidant Restrictive Food Intake Disorder",
"Middle Aged"
] | [
"Journal Article",
"Multicenter Study"
] | 21 | 7 | e0354232 | pmc-id: PMC13426971; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536627/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42536626 | 10.1371/journal.pone.0354876 | Anatomical fit of the oneKNEE tibia design using statistical shape modeling | Modern tibial implants should be designed to achieve an optimal anatomical fit. The aim of this study was to evaluate how well a newly developed tibial implant design (oneKNEE® - B. Braun Aesculap, Tuttlingen, Germany) matches patient anatomy compared to three existing implant systems, using Statistical Shape Models (S... | PLoS One | PloS one | 2026 | 2,026 | [
"Dupraz I",
"Minoda Y",
"Kornilov N",
"Altermann B",
"Hauff P",
"Bollinger A",
"Richter B",
"Grupp TM"
] | Dupraz I | Grupp TM | [
"Humans",
"Tibia",
"Prosthesis Design",
"Models, Statistical",
"Tomography, X-Ray Computed",
"Female",
"Male",
"Asian People",
"White People",
"Aged",
"Knee Prosthesis",
"Middle Aged",
"Arthroplasty, Replacement, Knee",
"Osteoarthritis, Knee",
"Models, Anatomic"
] | [
"Journal Article"
] | 21 | 7 | e0354876 | pmc-id: PMC13426962; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42536626/ | jkeNNjHj0zxqbmbkN | 60sfVYcL4g9w4etuD |
42537647 | 10.1016/j.cell.2026.07.007 | Spatial atlas of the human brain vasculature reveals specialized cell ensembles | The brain vasculature comprises diverse specialized cells that are essential for brain function, yet their spatial organization remains poorly understood. Here, we construct a comprehensive cerebrovascular cell atlas encompassing 314,535 transcriptomes that captures the arteriovenous axis and defines consensus cell sta... | Cell | Cell | 2026 Jul 31 | 2,026 | [
"Wang JC",
"Sanchez D",
"Arul S",
"Gülsuyu B",
"Gopinadhan A",
"Mukhtar T",
"Kim J",
"Andrews JP",
"Alonso Cee Williams M",
"Jung Y",
"Hashimoto ML",
"Kim CN",
"Bhalla S",
"Ewing-Crystal NA",
"Bernabei JM",
"Letchuman V",
"Haddad AF",
"Hemphill K",
"Weinsheimer SM",
"Kim H",
... | Wang JC | Winkler EA | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42537647/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42532044 | 10.1016/j.cell.2026.07.020 | Dietary arginine drives codon-dependent MHC class I translation and improves immunity in colon tumorigenesis and respiratory viral infection | Amino acid levels fluctuate across diverse pathological conditions. Whether such amino acid modulations directly shape pathophysiology by regulating host gene expression remains unknown. We found that extracellular arginine restriction, observed in cancer and infection, represses specific arginine tRNAs-directly suppre... | Cell | Cell | 2026 Jul 30 | 2,026 | [
"Wu Q",
"Seydlitz LM",
"Iakimov V",
"Hsu DJ",
"Habibzadeh P",
"Hoffmann HH",
"Paty PB",
"Rice CM",
"Tavazoie SF"
] | Wu Q | Tavazoie SF | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42532044/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42532043 | 10.1016/j.cell.2026.07.010 | Basement membrane turnover controls cell shape | The regulation of 3D cell shape is a fundamental problem of life. In multicellular tissues, cell shape emerges through the balance of forces inside and outside the cell. In epithelia, the basement membrane (BM) is the first extracellular barrier that cells sense biochemically and mechanically. Despite this, little is k... | Cell | Cell | 2026 Jul 30 | 2,026 | [
"Barrientos R",
"Meadowcroft B",
"Sánchez-Sánchez BJ",
"Stramer BM",
"Paluch EK",
"Charras G",
"Banerjee S",
"Šarić A",
"Mao Y"
] | Barrientos R | Mao Y | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42532043/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42526439 | 10.1016/j.cell.2026.07.011 | Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation | Tick-borne orthonairoviruses, including the emerging wetland virus (WELV), pose a growing public health concern as cases increase, yet their pathogenesis remains unclear. Here, we show that WELV infection causes fatal liver dysfunction in patients, characterized by elevated hepatic enzymes, triacylglycerol accumulation... | Cell | Cell | 2026 Jul 29 | 2,026 | [
"Wang C",
"Zheng X",
"Zhang Y",
"Shang X",
"Qu Q",
"Li C",
"Zhang X",
"Jin N",
"Liu W",
"Li H"
] | Wang C | Li H | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42526439/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42526438 | 10.1016/j.cell.2026.07.016 | CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer | Immune aging impairs T cell-mediated tumor control as well as cancer immunotherapy outcomes. The most important drivers of T cell dysfunction in aged tumors remain unknown. We performed single-cell CRISPR screens to identify Dusp5 and Zfp219 as key regulators of CD8+ T cell persistence and effector differentiation with... | Cell | Cell | 2026 Jul 29 | 2,026 | [
"Chen ACY",
"Ji KY",
"Yerinde C",
"Knudsen NH",
"Bi K",
"Hao S",
"Zhabotynsky V",
"Martinez D",
"Carmona-LaSalle TJ",
"Taguchi K",
"Xu KH",
"Seider EM",
"Schwartz MA",
"Zschummel M",
"Nieman LT",
"Yates KB",
"Gazzaniga FS",
"Miller BC",
"Mempel TR",
"Manguso RT",
"Hacohen N",... | Chen ACY | Sen DR | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42526438/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42520803 | 10.1016/j.cell.2026.07.003 | Why machines don't speak biology: Toward native biological language models | Recent advances in AI inspire visions of universal models of biology. Yet living systems are evolved, emergent processes whose behaviors cannot be inferred from their parts alone. We propose grounding AI in canonical biological processes, constructing data-driven world models with explicit mechanistic links across mole... | Cell | Cell | 2026 Jul 28 | 2,026 | [
"Stelzer Y",
"Tanay A"
] | Stelzer Y | Tanay A | [] | [
"Journal Article",
"Review"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42520803/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42520802 | 10.1016/j.cell.2026.07.012 | Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system | Defense-associated reverse transcriptase (DRT) systems mediate antiviral immunity through distinct modes of cDNA synthesis: class 1 DRTs catalyze untemplated synthesis, whereas class 2 DRTs polymerize non-coding RNA-templated products. However, how these distinct modes drive defense remains unclear. Here, we report tha... | Cell | Cell | 2026 Jul 28 | 2,026 | [
"Wang M",
"Yoneyama K",
"Žedaveinytė R",
"Ishikawa J",
"Tang S",
"Le HC",
"Wiegand T",
"Ramirez JL",
"Nagahata N",
"Ma Y",
"Zhang DJ",
"Helmeczi E",
"Berisa M",
"Jovanovic M",
"Hiraizumi M",
"Yamashita K",
"Nishimasu H",
"Sternberg SH"
] | Wang M | Sternberg SH | [] | [
"Journal Article"
] | null | null | null | pmc-id: PMC13419432;manuscript-id: NIHMS2196824; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42520802/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42508404 | 10.1016/j.cell.2026.07.009 | Advancing cancer detection and treatment using longitudinal routine clinical data | Cancer management remains fragmented across its continuum, from late-stage diagnosis and salvage therapies to non-personalized surveillance. Here, we present Oncoformer, a unified multimodal transformer model trained on the China Oncology Multimodal Prediction and Surveillance Study (COMPASS) cohort (3.67 million indiv... | Cell | Cell | 2026 Jul 27 | 2,026 | [
"Liu F",
"Wang K",
"Xu H",
"Tang C",
"Shen X",
"Wang M",
"Yang L",
"Yang L",
"Liu L",
"Hu C",
"Li G",
"Wu W",
"Zou Z",
"Li B",
"Liu S",
"Kang J",
"Kong J",
"Li T",
"Wong IN",
"Huang X",
"Chen G",
"Lu W",
"Ziyar I",
"Zhang CL",
"Sun Y",
"Lin W",
"Ou C",
"Fok M",
... | Liu F | Zhang K | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42508404/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42497867 | 10.1016/j.cell.2026.06.005 | UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling | Systematically simulating and predicting phenotypic effects of diverse interventions across heterogeneous cellular environments is central to the vision of artificial intelligence virtual cell (AIVC). However, disparities in perturbagen modalities, assay formats, and data production efficiency hinder unified modeling a... | Cell | Cell | 2026 Jul 24 | 2,026 | [
"Li Y",
"Zeng M",
"Zhu J",
"Liu L",
"Wang F",
"Huang L",
"Yang F",
"Li M",
"Yao J"
] | Li Y | Yao J | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42497867/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42497866 | 10.1016/j.cell.2026.06.039 | Dynamic dimer-of-dimers architecture defines Mg(2+) transport in human CNNM4 | Mg2+ is essential for all living organisms, yet its transport across mammalian membranes remains poorly understood. Here, we present cryoelectron microscopy (cryo-EM) structures of a full-length mammalian Mg2+ transporter on the plasma membrane, human CNNM4, in outward-facing and occluded states, revealing an unexpecte... | Cell | Cell | 2026 Jul 24 | 2,026 | [
"Bai Z",
"Zhou XE",
"Lü W",
"Du J"
] | Bai Z | Du J | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42497866/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42492508 | 10.1016/j.cell.2026.07.005 | An Oryza orphan gene confers trans-species drought tolerance | Drought threatens crop productivity, yet enhancing tolerance often compromises yield. Abscisic acid (ABA) signaling is central to drought response, but its deep conservation can constrain adaptive flexibility. Here, we identify ROAD1 (rice orphan gene adapted for drought 1), an Oryza-specific orphan gene that confers r... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Tu H",
"Liu Q",
"Ye T",
"Ye Y",
"Feng X",
"Shen L",
"Li S",
"Bai S",
"Liu X",
"Liu X",
"Wang H",
"Li X",
"Lin J",
"Wang H",
"Chen Y",
"Feng Z",
"Ji B",
"Ding J",
"Li W",
"Zhang J",
"Dai M",
"Dong F",
"Hu H",
"Tang N",
"Lai X",
"Xiong H",
"Xiong L"
] | Tu H | Xiong L | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42492508/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42492507 | 10.1016/j.cell.2026.07.001 | Trichoderma swollenin activates AtABCB5-dependent auxin efflux to promote plant development | The beneficial fungus Trichoderma enhances plant growth and stress tolerance through poorly understood mechanisms. Here, we show that Trichoderma harzianum swollenin ThSWO contributes to efficient root colonization and plant growth promotion. ThSWO traverses the plant cell wall and localizes to the plasma membrane, whe... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Lu J",
"Liu J",
"Jiang S",
"Xu Y",
"Yan Z",
"Li L",
"Zhang F",
"Chen W",
"Xu D",
"Li Y",
"Liu B",
"Raza W",
"Xuan W",
"Liu D",
"Shen Q"
] | Lu J | Shen Q | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42492507/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42492495 | 10.1016/j.cell.2026.06.030 | Bacteriophage genome-wide transposon mutagenesis | Bacteriophage genomes are densely packed with coding sequences and frequently encode genes of unknown function. Unbiased phage functional genomics approaches are therefore needed, particularly for large lytic phages. Here, we harness the mariner transposase to develop phage transposon mutagenesis and sequencing (phage ... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Chan A",
"Yee WX",
"Mozumdar D",
"Kokontis C",
"Rojas-Montero M",
"Liu M",
"Yang Y",
"Yuping L",
"Bondy-Denomy J"
] | Chan A | Bondy-Denomy J | [
"DNA Transposable Elements",
"Genome, Viral",
"Bacteriophages",
"Pseudomonas aeruginosa",
"Mutagenesis"
] | [
"Journal Article"
] | 189 | 15 | 4810-4824.e7 | pmc-id: PMC13428642;manuscript-id: NIHMS2198040; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42492495/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42492494 | 10.1016/j.cell.2026.06.024 | Auxin signaling | Following its discovery nearly a century ago, the signaling molecule auxin has captured the interest of plant scientists. Mostly through genetics, key components of the auxin response were identified, and these were rapidly connected in a topologically simple nuclear auxin pathway (NAP). While the identification of the... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Chu J",
"Ang ACH",
"de Roij M",
"Strader L",
"Xu T",
"Weijers D"
] | Chu J | Weijers D | [
"Indoleacetic Acids",
"Signal Transduction",
"Phosphorylation",
"Plant Proteins",
"Gene Expression Regulation, Plant",
"Plant Growth Regulators",
"Arabidopsis",
"Arabidopsis Proteins"
] | [
"Journal Article",
"Review"
] | 189 | 15 | 4531-4547 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42492494/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42492493 | 10.1016/j.cell.2026.06.021 | Do autoantibodies shape cancer immunosurveillance? | Why cancer arises, progresses, or proves fatal in some people but not others remains largely unresolved. Antibody repertoires, including autoantibodies targeting immune pathways, may shape cancer immunosurveillance. Mapping antibody landscapes across cancer-free, at-risk, and cancer-affected individuals could clarify t... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Bastard P",
"Hulett T",
"Smith-Byrne K",
"Landegren N",
"Mogensen TH",
"Fellay J",
"Travis RC",
"Casanova JL",
"Dang CV",
"Lu X"
] | Bastard P | Lu X | [
"Humans",
"Neoplasms",
"Autoantibodies",
"Animals",
"Immunologic Surveillance"
] | [
"Journal Article"
] | 189 | 15 | 4525-4530 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42492493/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42492492 | 10.1016/j.cell.2026.07.002 | The silicon citizen naturalist | Smartphone-wielding citizen scientists and an AI called FLORIST are transforming ecology at the continental scale. In this issue of Cell, when Tibbs-Cortes et al. pair the crowdsourced data with controlled genetics, they discover how switchgrass times its flowering to outwit both frost and heat, depending on latitude. | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Hudson ME",
"Battu G"
] | Hudson ME | Battu G | [
"Citizen Science",
"Panicum",
"Flowers"
] | [
"Journal Article",
"Comment"
] | 189 | 15 | 4522-4524 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42492492/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42492491 | 10.1016/j.cell.2026.06.023 | UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins | How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3' UTR of an mRNA co-translationally chaperones the protein it encodes, preventing intrinsically disordered regions from making inappropriate contacts. This functionality, localized to mesh-like conde... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Linsenmeier M",
"Shorter J"
] | Linsenmeier M | Shorter J | [
"Molecular Chaperones",
"Intrinsically Disordered Proteins",
"3' Untranslated Regions",
"Humans",
"Animals",
"Protein Folding",
"RNA, Messenger"
] | [
"Journal Article",
"Comment"
] | 189 | 15 | 4519-4521 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42492491/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42486084 | 10.1016/j.cell.2026.06.040 | The intrinsic cardiac nervous system is essential for cardiac function and survival | The intrinsic cardiac nervous system (ICNS) is a key node in heart-brain communication and an emerging target for cardiac therapy, yet its physiological importance and functional organization remain poorly understood. Here, we show that the ICNS is essential for cardiac performance and survival across conditions. Using... | Cell | Cell | 2026 Jul 22 | 2,026 | [
"Xu QJ",
"Applegate MC",
"Hsu IY",
"Kogan RP",
"Hafez OA",
"Wang RL",
"Rios Coronado PE",
"Young LH",
"Zeng X",
"Zhang L",
"Chang RB"
] | Xu QJ | Chang RB | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42486084/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42486083 | 10.1016/j.cell.2026.07.006 | Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development | Genes that define cell identity are often highly transcribed, but how their activity is regulated to prevent pathological dysregulation remains elusive. Using a two-tiered genetic screen, we identify a network of genes regulating hypertranscribed loci, which is notably enriched for genes mutated in developmental disord... | Cell | Cell | 2026 Jul 22 | 2,026 | [
"Zhang T",
"Li X",
"Zhou W",
"Li ZL",
"Bi J",
"Ma X",
"Li X",
"Fan Y",
"Hong Y",
"Wang S",
"Wang Y",
"Yang L",
"Chen Y",
"Qin W",
"Wang H",
"Xi Q",
"Shi S",
"Liu N"
] | Zhang T | Liu N | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42486083/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42480528 | 10.1016/j.cell.2026.06.029 | Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer | Protein-protein interactions underlie biological complexity, and modeling their coevolution is essential for characterizing and engineering molecular assemblies. While protein and genomic language models have excelled at modeling individual proteins, extending these capabilities to protein complexes remains challenging... | Cell | Cell | 2026 Jul 21 | 2,026 | [
"Akiyama Y",
"Zhang Z",
"Tang O",
"Kim RS",
"Mirdita M",
"Steinegger M",
"Ovchinnikov S"
] | Akiyama Y | Ovchinnikov S | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42480528/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42480527 | 10.1016/j.cell.2026.06.036 | Localized PD-1 CAR T therapy reprograms neuroinflammation | B cell-depleting therapies are effective in multiple sclerosis (MS), yet some patients relapse, underscoring the need for more precise interventions. To identify new therapeutic targets, we generated a single-cell RNA sequencing (scRNA-seq) atlas of cerebrospinal fluid (CSF), brain, and blood from non-inflammatory cont... | Cell | Cell | 2026 Jul 21 | 2,026 | [
"Shalita R",
"Ben Yehuda M",
"Gur C",
"Frid Y",
"McGrath S",
"Suhler R",
"Bolokan L",
"Eisenberg V",
"Eshed RS",
"Shlomi-Loubaton S",
"Tofield A",
"Vardy K",
"Zada M",
"Kurilovich A",
"David E",
"Jaitin D",
"Mazuz K",
"Avellino R",
"Tzemach R",
"Kuznetsov Y",
"Fellus-Alyagor ... | Shalita R | Amit I | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42480527/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42480526 | 10.1016/j.cell.2026.06.035 | CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics | Meningeal (dural) lymphatics are essential for cerebrospinal fluid (CSF) clearance to cervical lymph nodes, yet the precise pathway is incompletely understood. Using a multifaceted approach in mice, we examined tracer dynamics and the CSF outflow pathway from the subarachnoid space (SAS) to the nasal mucosa and identif... | Cell | Cell | 2026 Jul 21 | 2,026 | [
"Hong SP",
"Jin C",
"Yang MJ",
"Jin H",
"Yoon JH",
"Choi DR",
"Jung J",
"Yuk CM",
"Antila S",
"Seo SJ",
"Admasu LA",
"Seo J",
"Lim KS",
"Chung WS",
"Alitalo K",
"McDonald DM",
"Koh GY"
] | Hong SP | Koh GY | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42480526/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42480525 | 10.1016/j.cell.2026.06.038 | A domestication-selected enhancer coordinates source-sink balance to improve harvest index and yield in maize | Crop yield is fundamentally determined by the harvest index, the proportion of photosynthates allocated to grain. However, its genetic and evolutionary basis remains elusive. Here, we show that the maize harvest index increased by 81% during domestication. A major locus, Harvest Index1 (HI1), contributes to this diverg... | Cell | Cell | 2026 Jul 21 | 2,026 | [
"Guo L",
"Xia J",
"Tang J",
"Zhang M",
"Chen T",
"Han X",
"Liu S",
"Wang X",
"Wu L",
"Tian F"
] | Guo L | Tian F | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42480525/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42476130 | 10.1016/j.cell.2026.06.031 | Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy | While gasdermin (GSDM)-mediated pyroptosis is a potent immune effector, its antiviral potential remains largely untapped. Here, we introduce viral protease-initiated lytic cell death (VID), a universal mRNA therapeutic platform inspired by the modular architecture of GSDM and the clinical success of mRNA vaccines. By e... | Cell | Cell | 2026 Jul 20 | 2,026 | [
"Li L",
"Yan XL",
"Wang HY",
"Zhou HY",
"Li YY",
"Ma W",
"Li J",
"Zhang RR",
"Lv L",
"Huang XY",
"Du H",
"Cao TS",
"Ye Q",
"Zhao H",
"Fu Y",
"Kang BH",
"Ding Q",
"Wu A",
"Huang YJ",
"Qin CF"
] | Li L | Qin CF | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42476130/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42476129 | 10.1016/j.cell.2026.06.037 | A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death | Developing cancer therapies that induce specific death of malignant cells is critical for preventing relapse. Highly effective strategies, such as immunotherapy, exemplify this principle. Here, we provide the mechanistic basis for a small-molecule approach that leverages chemically induced proximity (CIP) to kill diffu... | Cell | Cell | 2026 Jul 20 | 2,026 | [
"Nix MN",
"Gourisankar S",
"Bowman KJ",
"Nettles SA",
"Yang H",
"Dwyer BG",
"Sarott RC",
"Abuzaid H",
"Martinez MM",
"Phillips N",
"Cabaud V",
"Hakobyan A",
"Arakelov V",
"Petrosyan G",
"Davtyan A",
"Wang Y",
"Simanauskaite JM",
"Romero BA",
"Jones HM",
"Krokhotin A",
"Lowens... | Nix MN | Crabtree GR | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42476129/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42468524 | 10.1016/j.cell.2026.06.033 | Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context | Enhancers are abundant and critical gene-distal cis-regulatory elements with distinct architectural features; however, a mechanistic understanding of their interactions within endogenous chromatin contexts remains challenging. Here, we developed a recombinase-mediated genome-rewriting platform to explore how a long-ran... | Cell | Cell | 2026 Jul 17 | 2,026 | [
"Zhou Z",
"Cheng Y",
"Lieberth J",
"Zhang J",
"Jin Y",
"Li A",
"Yu H",
"Ozer A",
"Lis JT"
] | Zhou Z | Lis JT | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42468524/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42468523 | 10.1016/j.cell.2026.06.032 | Skin-innervating glutamatergic neurons modulate aging | Peripheral nerves regulate skin homeostasis by secreting neurotransmitters, but their role during skin aging remains incompletely understood. Here, we report that cutaneous denervation accelerates skin aging, as evidenced by collagen reduction. Neurofilament heavy chain (Nefh) is decreased in aged skin and is predomina... | Cell | Cell | 2026 Jul 17 | 2,026 | [
"Wang Z",
"Jin X",
"Wu Y",
"Ding W",
"Zhang F",
"Sun Y",
"Lou F",
"Bai J",
"Yang X",
"Zhou H",
"Liang J",
"Cai X",
"Li Y",
"Zheng X",
"Han J",
"Tong F",
"Yang Q",
"Fang Z",
"Zhao L",
"Shen Q",
"Xu Z",
"Deng S",
"Fan L",
"Tong J",
"Tong L",
"Wang J",
"Gao M",
"Fa... | Wang Z | Wang H | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42468523/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42462711 | 10.1016/j.cell.2026.06.028 | Boron-bridged GIPCs stabilize cell wall anchoring and PIN polar domains | Boron (B) is an essential plant micronutrient whose deficiency impairs global crop yields. Glycosylinositol phosphorylceramides (GIPCs) are major lipids in the plasma membrane (PM), and PIN-FORMED (PIN) proteins mediate polar auxin transport (PAT) via asymmetric PM localization. This study demonstrates that these compo... | Cell | Cell | 2026 Jul 16 | 2,026 | [
"He M",
"Zhang C",
"Li Z",
"Tang C",
"Wang Y",
"Jiao Y"
] | He M | Jiao Y | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42462711/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42462710 | 10.1016/j.cell.2026.06.027 | Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues | Cell and tissue functions arise from complex interactions among numerous genes, and a systematic understanding of these functions requires isoform-resolved transcriptomic analysis of single cells with high spatial resolution. Here, we introduce an in situ RNA amplification method and its integration with multiplexed er... | Cell | Cell | 2026 Jul 16 | 2,026 | [
"Cohen L",
"Halpern AR",
"Blosser TR",
"Che ZP",
"Pan X",
"Zhuang X"
] | Cohen L | Zhuang X | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42462710/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42462709 | 10.1016/j.cell.2026.06.034 | Spatial proximity sequencing maps developmental dynamics in the germinal center | Spatial profiling of proteins and protein interactions facilitates understanding of cell functions within tissues and is essential for studies in signaling, immunity, and cancer. We present spatial proximity sequencing (Sprox-seq) for simultaneous profiling of surface proteins, protein complexes, and mRNAs, recording t... | Cell | Cell | 2026 Jul 16 | 2,026 | [
"Wang H",
"Xia J",
"Rahman PMSM",
"Keisham B",
"Padhi A",
"Deng Y",
"Li Y",
"Vistain L",
"Kim S",
"Mercado-Vásquez G",
"Khan AA",
"Clark MR",
"Tay S"
] | Wang H | Tay S | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42462709/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42456655 | 10.1016/j.cell.2026.05.033 | A spliceosome-independent eukaryote generated by complete intron removal | Spliceosomal introns impose a universal processing burden on eukaryotes and obstruct genome minimization because their essentiality remains unresolved. By exploiting Spo11-independent meiosis in synthetic single-chromosome Saccharomyces cerevisiae, the complete deletion of all 300 spliceosomal introns was achieved, gen... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Man X",
"Zhang WT",
"Zhang YD",
"Li QX",
"Dai P",
"Jiang W",
"Zhou JQ"
] | Man X | Zhou JQ | [
"Introns",
"Spliceosomes",
"Saccharomyces cerevisiae",
"Saccharomyces cerevisiae Proteins",
"RNA Splicing",
"Meiosis"
] | [
"Journal Article"
] | 189 | 15 | 4637-4649.e5 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42456655/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42425064 | 10.1016/j.cell.2026.06.006 | Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies | Alzheimer's disease (AD) remains the leading cause of dementia worldwide and an escalating global health crisis. The hallmark amyloid plaques and neurofibrillary tangles (NFT) are now known to be accompanied by a complex array of pathologies that culminate in neurodegeneration and cognitive decline. New disease-modifyi... | Cell | Cell | 2026 Jul 9 | 2,026 | [
"Rudman MD",
"Ulrich JD",
"Holtzman DM"
] | Rudman MD | Holtzman DM | [
"Alzheimer Disease",
"Humans",
"Animals",
"Apolipoproteins E",
"Plaque, Amyloid",
"Amyloid beta-Peptides"
] | [
"Journal Article",
"Review"
] | 189 | 14 | 4193-4224 | pmc-id: PMC13361001;manuscript-id: NIHMS2184915; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42425064/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42425063 | 10.1016/j.cell.2026.06.018 | Bridging omics and physiology to build multimodal clocks of human aging | Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associated signatures to construct a multi-layer framework for quantifying biological aging across scales. | Cell | Cell | 2026 Jul 9 | 2,026 | [
"Koyuncu S",
"Petrovic D",
"Vilchez D"
] | Koyuncu S | Vilchez D | [
"Humans",
"Aging",
"Multiomics"
] | [
"Journal Article",
"Comment"
] | 189 | 14 | 4190-4192 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42425063/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42425062 | 10.1016/j.cell.2026.06.011 | Rewriting Duchenne muscular dystrophy therapy | In this issue of Cell, Guo et al. report the development of a new exon-skipping, RNA-editing-based therapy for Duchenne muscular dystrophy. The dual mechanism of action through both ADAR-dependent and -independent pathways has the potential to be more effective and require a lower dosing frequency than currently availa... | Cell | Cell | 2026 Jul 9 | 2,026 | [
"Gonzalez-Perez P",
"Blackstone C"
] | Gonzalez-Perez P | Blackstone C | [
"Muscular Dystrophy, Duchenne",
"Humans",
"Exons",
"RNA Editing",
"Animals",
"Adenosine Deaminase",
"Genetic Therapy",
"RNA-Binding Proteins",
"Oligonucleotides, Antisense"
] | [
"Journal Article",
"Comment"
] | 189 | 14 | 4188-4189 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42425062/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42425061 | 10.1016/j.cell.2026.05.001 | Photosynthetic medicine: Engineering a plant-derived nanofoundry to power mammalian cells | Mammalian eyes receive constant visible light yet lack photosynthesis. Xing et al. engineer an intact thylakoid grana nanoparticle enabling light-driven NADPH production within corneal cells, restoring antioxidant defenses and interrupting inflammatory cycles in dry eye disease. This work positions borrowed photosynthe... | Cell | Cell | 2026 Jul 9 | 2,026 | [
"Saiding Q",
"Xie T",
"Tao W"
] | Saiding Q | Tao W | [
"Photosynthesis",
"Animals",
"Humans",
"Thylakoids",
"NADP",
"Nanoparticles"
] | [
"Journal Article",
"Comment"
] | 189 | 14 | 4185-4187 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42425061/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42419303 | 10.1016/j.cell.2026.06.025 | Map of spiking activity underlying change detection in the mouse visual system | Visual behavior requires coordinated activity across hierarchically organized brain circuits. Understanding this complexity demands datasets that are both large-scale (sampling many areas) and dense (recording many neurons in each area). Here, we present a database of spiking activity across the mouse visual system-inc... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Bennett C",
"Gale SD",
"Heller G",
"Ramirez TK",
"Belski H",
"Piet A",
"Zobeiri O",
"Amster A",
"Arkhipov A",
"Cahoon A",
"Caldejon S",
"Carlson M",
"Casal L",
"Daniel SF",
"Farrell C",
"Garrett M",
"Gillis R",
"Grasso C",
"Hardcastle BJ",
"Hytnen R",
"Johnson T",
"Ledocho... | Bennett C | Olsen SR | [
"Animals",
"Mice",
"Visual Cortex",
"Neurons",
"Optogenetics",
"Mice, Inbred C57BL",
"Action Potentials",
"Thalamus",
"Brain Mapping",
"Male",
"Mesencephalon",
"Visual Perception",
"Female",
"Photic Stimulation"
] | [
"Journal Article"
] | 189 | 15 | 4775-4791.e13 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42419303/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42392077 | 10.1016/j.cell.2026.05.024 | A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions | Virological research has traditionally focused on individual viruses or viral families. Advances in DNA synthesis now allow large-scale construction of individual gene products, enabling systematic exploration of the virome. Here, we developed a barcoded library of ∼12,000 viral open reading frames (vORFs) from 513 vir... | Cell | Cell | 2026 Jun 30 | 2,026 | [
"Fujimura E",
"O'Leary CN",
"Li MZ",
"Roberts RA",
"Glassman CR",
"Paulo JA",
"Jiang H",
"Abdelfattah NS",
"Wooten EC",
"Mirman Z",
"Harper JW",
"Cole PA",
"Elledge SJ"
] | Fujimura E | Elledge SJ | [] | [
"Journal Article"
] | null | null | null | pmc-id: PMC13429030;manuscript-id: NIHMS2180536; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42392077/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42385704 | 10.1016/j.cell.2026.06.015 | Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs | Endosymbiosis has spurred the evolution of new organelles across life. Corals and other cnidarians have repeatedly evolved an organelle, called the symbiosome, which houses intracellular algal symbionts. However, the molecular mechanisms enabling this repeated evolution remain unclear. Using the sea anemone Aiptasia, w... | Cell | Cell | 2026 Jul 1 | 2,026 | [
"Maruyama S",
"Henderson CF",
"Swinhoe N",
"Kowalewski GP",
"Meier EK",
"Engelke TR",
"Cleves PA"
] | Maruyama S | Cleves PA | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42385704/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42385703 | 10.1016/j.cell.2026.06.022 | LEF1 and niche factors determine T cell stemness across chronic diseases | In settings of persistent (self or foreign) antigen, such as autoimmunity and chronic infection, immune responses are sustained by stem-like T cells. Although TCF1 has emerged as a key transcription factor (TF) associated with stemness, the TCF1hi population is heterogeneous, raising the question of whether TCF1 exclus... | Cell | Cell | 2026 Jul 9 | 2,026 | [
"Miakicheva S",
"Hawley KM",
"Zumbo P",
"Gearty SV",
"Grassmann S",
"Naizir B",
"Chiu E",
"Carson S",
"Kissner M",
"Owyong M",
"Zhang Y",
"Washburn R",
"Sun JC",
"Chaligné R",
"Reiner SL",
"Maillard I",
"Betel D",
"Schietinger A"
] | Miakicheva S | Schietinger A | [
"Lymphoid Enhancer-Binding Factor 1",
"Animals",
"Mice",
"Diabetes Mellitus, Type 1",
"Chronic Disease",
"Stem Cell Niche",
"T-Lymphocytes",
"Hepatocyte Nuclear Factor 1-alpha",
"Cell Differentiation",
"Stem Cells",
"Humans"
] | [
"Journal Article"
] | 189 | 14 | 4325-4341.e10 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42385703/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42385702 | 10.1016/j.cell.2026.06.013 | Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders | Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD) represent two major categories of neurodegenerative disorders-TAR DNA-binding protein 43 (TDP-43) and tau proteinopathies-for which the mechanisms driving neuronal death remain unclear. Single-cell whole-genome sequencing o... | Cell | Cell | 2026 Jul 1 | 2,026 | [
"Zhou Z",
"Luquette LJ",
"Dong G",
"Kim J",
"Ku J",
"Kim K",
"Ramesh N",
"Bae M",
"Caplin A",
"Shao DD",
"Sahile B",
"Essuman K",
"Goodman E",
"Miller MB",
"Huang AY",
"Nathan WJ",
"Nussenzweig A",
"Park PJ",
"Lagier-Tourenne C",
"Lee EA",
"Walsh CA"
] | Zhou Z | Walsh CA | [] | [
"Journal Article"
] | null | null | null | pmc-id: PMC13340254;manuscript-id: NIHMS2188418; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42385702/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42385701 | 10.1016/j.cell.2026.06.014 | Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis | Understanding organ formation requires capturing molecular information simultaneously in three-dimensional (3D) space and across developmental time. To this end, we developed 3D DNase-Enhanced Expression Profiling (3DEEP), a tissue-clearing approach that removes genomic DNA to extend spatial transcriptomic profiling hu... | Cell | Cell | 2026 Jul 1 | 2,026 | [
"Asami S",
"Yin C",
"Fan J",
"Garza LA",
"Kalhor R"
] | Asami S | Kalhor R | [] | [
"Journal Article"
] | null | null | null | pmc-id: PMC13379681;manuscript-id: NIHMS2193327; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42385701/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42379169 | 10.1016/j.cell.2026.06.010 | Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data | We introduce a whole-cell digital twin framework that integrates four-dimensional (4D) (x, y, z, and t) lattice light-sheet microscopy with particle-based reaction-diffusion simulations in ReaDDy to model mesoscale intracellular organelle dynamics. Using fluorescence microscopy data from live Cal27 cells, we construct ... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Arkfeld E",
"Wang Z",
"Hakozaki H",
"Schöneberg J"
] | Arkfeld E | Schöneberg J | [
"Humans",
"Cell Membrane",
"Cell Nucleus",
"Computer Simulation",
"Dyneins",
"Kinesins",
"Microscopy, Fluorescence",
"Microtubules",
"Mitochondria",
"Mitochondrial Dynamics"
] | [
"Journal Article"
] | 189 | 15 | 4581-4593.e6 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42379169/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42379168 | 10.1016/j.cell.2026.06.017 | Systematic discovery of pathogen effector functions across human pathogens and pathways | Pathogens deploy effector proteins to exploit host cell biology, and most effector open reading frames (ORFs) are rapidly evolving and lack functional annotation. We developed the effector ORFeome (eORFeome), a scalable functional genomics platform encompassing 3,835 effector ORFs from diverse viruses, bacteria, and pa... | Cell | Cell | 2026 Jun 30 | 2,026 | [
"Pachano T",
"Leng H",
"Dugied G",
"Tribble T",
"Loubiere V",
"Lee Y",
"Rauh F",
"Manon V",
"Yuan K",
"Nurtanto J",
"Schleiffer A",
"Young V",
"Weller B",
"Lyons EA",
"Hass MR",
"Kottyan LC",
"Weirauch MT",
"Fuxman Bass JI",
"Newton HJ",
"Ensminger AW",
"Falter-Braun P",
"C... | Pachano T | Taipale M | [] | [
"Journal Article"
] | null | null | null | pmc-id: PMC13378530;manuscript-id: NIHMS2193300; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42379168/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42379167 | 10.1016/j.cell.2026.06.012 | Structural basis for host membrane binding and remodeling by invading malaria parasites | The Plasmodium moving junction is central to malarial host-cell invasion, and yet its function remains unclear. Here, we determine the endogenous structure of the basic repeating unit of the moving junction, purified directly from invasion-stalled Plasmodium falciparum parasites, revealing a sailboat-shaped 1:1:1:1 ass... | Cell | Cell | 2026 Jun 30 | 2,026 | [
"Haile MT",
"Kaxiras DA",
"Zhen J",
"Lee CL",
"Jiang B",
"Small-Saunders JL",
"Ho CM"
] | Haile MT | Ho CM | [] | [
"Journal Article"
] | null | null | null | pmc-id: PMC13322224;manuscript-id: NIHMS2186715; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42379167/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42379166 | 10.1016/j.cell.2026.06.009 | Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning | Tissue regeneration requires de novo patterning, which has been proposed to be facilitated by cellular heterogeneity. Yet how such heterogeneities are integrated with the mechanochemical state of the tissue and stabilized at the chromatin level into stable, spatially organized fates remains poorly understood. Using in ... | Cell | Cell | 2026 Jun 30 | 2,026 | [
"Schwayer C",
"Barbiero S",
"Brückner DB",
"Oost KC",
"Baader C",
"Repina NA",
"Kim J",
"Diaz OE",
"Uccelli I",
"Capolupo L",
"Meylan LC",
"Kalck V",
"Moos F",
"Suppinger S",
"Yang Q",
"Schnabl J",
"Kilik U",
"Bourdon M",
"Camp JG",
"Stockinger B",
"Ferrari A",
"Bühler M",
... | Schwayer C | Liberali P | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42379166/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42372723 | 10.1016/j.cell.2026.06.008 | Arc mediates intercellular tau transmission via extracellular vesicles | Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critical for the release of tau in neuronal extracellular vesicles (EVs) via a direct protein-protein interaction. Brain EVs purified from transgenic rTg4510 mutant tau mice (rT... | Cell | Cell | 2026 Jul 23 | 2,026 | [
"Tyagi M",
"de Hoog E",
"Grega M",
"Sullivan KR",
"Walker AC",
"Chadha R",
"Northrop A",
"Fábián B",
"Hummer G",
"Fuxreiter M",
"Hyman BT",
"Shepherd JD"
] | Tyagi M | Shepherd JD | [
"Animals",
"tau Proteins",
"Extracellular Vesicles",
"Humans",
"Mice",
"Cytoskeletal Proteins",
"Mice, Knockout",
"Alzheimer Disease",
"Brain",
"Nerve Tissue Proteins",
"Neurons",
"Phosphorylation",
"Mice, Transgenic"
] | [
"Journal Article"
] | 189 | 15 | 4706-4723.e13 | pmc-id: PMC13315601;manuscript-id: NIHMS2186669; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42372723/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42372722 | 10.1016/j.cell.2026.06.020 | Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression | null | Cell | Cell | 2026 Jul 9 | 2,026 | [
"Kim J",
"Hwang Y",
"Kim S",
"Kwon D",
"Park J",
"Cho B",
"An S",
"Kang S",
"Kim Y",
"Kim S",
"Lengner CJ",
"Kim S",
"Kwon Y",
"Sung JS",
"Kim J"
] | Kim J | Kim J | [] | [
"Published Erratum"
] | 189 | 14 | 4517-4518 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42372722/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42361798 | 10.1016/j.cell.2026.05.048 | Geometric constraints on the architecture of mammalian cortical connectomes | The intricate network of axonal fibers forming the mammalian cortical connectome exhibits a complex topology, being neither completely regular nor random. It also has a characteristic topography in which distinct regions have specific connectivity profiles. How such properties arise remains a mystery. Here, we formulat... | Cell | Cell | 2026 Jun 26 | 2,026 | [
"Normand F",
"Gajwani M",
"Cao T",
"Cruddas J",
"Sangchooli A",
"Oldham S",
"Holmes A",
"Robinson PA",
"Pang JC",
"Fornito A"
] | Normand F | Fornito A | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42361798/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42361797 | 10.1016/j.cell.2026.06.004 | Iron drives protease-independent cleavage of gasdermin D in allergic airway diseases | Gasdermin D (GSDMD)-mediated interleukin (IL)-33 secretion by lung epithelial cells initiates airway inflammation upon allergen challenge. How environmental allergens activate GSDMD remains elusive. Here, we demonstrate that exposing epithelial cells to allergens triggers protease-activated receptor 1 (PAR1)-dependent ... | Cell | Cell | 2026 Jun 26 | 2,026 | [
"Chen S",
"Deng F",
"Peng B",
"Liu L",
"Wang J",
"Jin F",
"Xu J",
"Lin D",
"Chen W",
"Zhang D",
"Yi C",
"Zhang J",
"Zhong S",
"Zhu L",
"Huang Y",
"Yang J",
"Wang R",
"Sun X",
"Zhang Y",
"Ling Z",
"Ma L",
"Liu X",
"Sun B"
] | Chen S | Sun B | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42361797/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42361796 | 10.1016/j.cell.2026.05.049 | Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis | Epithelial mechanosensation maintains tissue homeostasis by sensing mechanical stimuli. Dysregulated mechanotransduction has been implicated in chronic pain, yet the molecular link between epithelial stress and persistent sensory dysfunction remains unclear. Here, we report that the mechanosensitive ion channel PIEZO1 ... | Cell | Cell | 2026 Jun 26 | 2,026 | [
"Kim MJ",
"Noh JH",
"Lee HY",
"Lee B",
"Park AD",
"Oh H",
"Kim GD",
"Lee HS",
"Oh Y",
"Hwang H",
"Kim C",
"Lee H",
"Li X",
"Oh MM",
"Lim D",
"Abraham SN",
"Cho Y",
"Chi SW",
"Choi HW"
] | Kim MJ | Choi HW | [] | [
"Journal Article"
] | null | null | null | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/42361796/ | 7ZrmW0u1sCa4DDeqf | xcuK1zfSY8rvcVEGB |
42538428 | 10.1038/s41591-026-04567-4 | Learning from routine health system data builds better neuroimaging AI models | null | Nat Med | Nature medicine | 2026 Jul 31 | 2,026 | [] | null | null | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42538428/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42538427 | 10.1038/s41591-026-04521-4 | End-to-end multimodal pathology foundation model with clinical dialogue | Recent rapid progress in the field of computational pathology has been enabled by foundation models. These models are beginning to move beyond encoding image patches toward whole-slide understanding, but their clinical utility remains limited. Here we present PRISM2, a multimodal slide-level foundation model trained on... | Nat Med | Nature medicine | 2026 Jul 31 | 2,026 | [
"Vorontsov E",
"Shaikovski G",
"Casson A",
"Viret J",
"Zimmermann E",
"Tenenholtz N",
"Wang YK",
"Bernhard JH",
"Godrich RA",
"Retamero JA",
"Shia J",
"Gonen M",
"Weiser MR",
"Klimstra DS",
"Yousfi R",
"Fusi N",
"Fuchs TJ",
"Severson K",
"Liu S"
] | Vorontsov E | Liu S | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42538427/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42538412 | 10.1038/d41591-026-00039-x | 'Heading' the ball linked to spikes in neural damage biomarkers | null | Nat Med | Nature medicine | 2026 Jul 31 | 2,026 | [
"O'Leary K"
] | O'Leary K | O'Leary K | [] | [
"News"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42538412/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42538411 | 10.1038/d41591-026-00038-y | Humanoid robots perform successful surgery in animals | null | Nat Med | Nature medicine | 2026 Jul 31 | 2,026 | [
"O'Leary K"
] | O'Leary K | O'Leary K | [] | [
"News"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42538411/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42527577 | 10.1038/s41591-026-04555-8 | Deciphering the role of histidine in cancer | null | Nat Med | Nature medicine | 2026 Jul 29 | 2,026 | [
"Cansiz F",
"Pope AN",
"Tasdogan A"
] | Cansiz F | Tasdogan A | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42527577/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42521821 | 10.1038/s41591-026-04552-x | Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial | Combining multidisciplinary care plans into integrated care pathways (ICPs) is scalable, generalizable and effective for several long-term conditions, but not evaluated in Long COVID (LC). Our phase 3, cluster-randomized, multicenter clinical trial investigated the effectiveness of ICP interventions for LC. Recruitment... | Nat Med | Nature medicine | 2026 Jul 28 | 2,026 | [
"STIMULATE-ICP Consortium"
] | STIMULATE-ICP Consortium | STIMULATE-ICP Consortium | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42521821/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42521820 | 10.1038/s41591-026-04558-5 | Maternal 6-valent group B Streptococcus vaccine in non-pregnant and pregnant females: a randomized phase 1/2 trial | Group B Streptococcus (GBS) disease is a major cause of infant morbidity and mortality. Capsular polysaccharide conjugate GBS vaccines have been evaluated for decades; however, none is licensed. This phase 1/2 trial evaluated an investigational maternal hexavalent polysaccharide-protein conjugate GBS vaccine (GBS6) in ... | Nat Med | Nature medicine | 2026 Jul 28 | 2,026 | [
"Madhi SA",
"Snaggs H",
"Skogeby Z",
"Feng Y",
"Barnabas S",
"Baker J",
"Fairlie L",
"Beeslaar J",
"Radley D",
"Jiang HQ",
"Silmon de Monerri NC",
"Simon R",
"McLaughlin L",
"Gaylord M",
"Skinner J",
"Munjal I",
"Anderson AS",
"Gurtman A"
] | Madhi SA | Gurtman A | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42521820/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42521819 | 10.1038/s41591-026-04542-z | Reducing the diagnostic odyssey in rare disease: why screening is not the only answer | null | Nat Med | Nature medicine | 2026 Jul 28 | 2,026 | [
"Wright CF",
"Phillips A",
"Wynn SL",
"Meade N",
"Baple EL",
"Lucassen AM",
"Jackson L"
] | Wright CF | Jackson L | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42521819/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42521818 | 10.1038/s41591-026-04548-7 | Global economic burden of depression in 154 countries from 2025 to 2050 | Depression is a major contributor to the global burden of diseases with substantial socioeconomic consequences. Here, to estimate the economic effects of depression, we developed a macroeconomic model using data from the World Bank and Global Burden of Disease Study 2021. The model estimated the impact of depression on... | Nat Med | Nature medicine | 2026 Jul 28 | 2,026 | [
"Cao Z",
"Luo Y",
"Jiao L",
"Chen W",
"Prettner K",
"Kuhn M",
"Bloom DE",
"Jamison DT",
"Bärnighausen TW",
"Chen S"
] | Cao Z | Chen S | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42521818/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42521817 | 10.1038/s41591-026-04492-6 | The genetic architecture of fibromyalgia across 2.5 million individuals | Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying 26 risk loci for fibromyalgia. The strongest associa... | Nat Med | Nature medicine | 2026 Jul 28 | 2,026 | [
"Kerrebijn I",
"Bjornsdottir G",
"Arbabi K",
"Urpa L",
"Haapaniemi H",
"Thorleifsson G",
"Stefansdottir L",
"Frangakis S",
"Valliere J",
"Kunorozva L",
"Abner E",
"Ji C",
"Kangur M",
"Aagaard B",
"Bliddal H",
"Brunak S",
"Bruun MT",
"Didriksen M",
"Erikstrup C",
"Finer S",
"G... | Kerrebijn I | Wainberg M | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42521817/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42509372 | 10.1038/s41591-026-04539-8 | Toward a test of medical AI superintelligence | null | Nat Med | Nature medicine | 2026 Jul 27 | 2,026 | [
"Goh E",
"Wu D",
"Walton C",
"McCoy LG",
"Perez A",
"Wegner L",
"Nateghi Haredasht F",
"Luo L",
"Lacar K",
"Buckley T",
"Schoeffler A",
"Brodeur P",
"Black KC",
"Havlik J",
"Liu Y",
"Chen PC",
"Schaekermann M",
"Rumsfeld J",
"Lopez-Martinez D",
"Maeder-York P",
"Singhal K",
... | Goh E | Chen JH | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42509372/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42509371 | 10.1038/s41591-026-04528-x | Longitudinal plasma proteomics predict phenoconversion to clinically manifest ALS | The study of pre-symptomatic amyotrophic lateral sclerosis (ALS) and the design of disease prevention trials are greatly hampered by our inability to predict which unaffected carriers of ALS-associated pathogenic variants will phenoconvert to clinically manifest disease and when. In this longitudinal Olink Explore, hig... | Nat Med | Nature medicine | 2026 Jul 27 | 2,026 | [
"Ran X",
"Wuu J",
"Qin ZS",
"McDermott MP",
"Cooper-Knock J",
"Li Y",
"Granit V",
"Grignon AL",
"Lin E",
"Fernandez MC",
"Colato D",
"Carberry N",
"Lill CM",
"Piazza P",
"Malaspina A",
"Benatar M"
] | Ran X | Benatar M | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42509371/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42498742 | 10.1038/s41591-026-04545-w | AI-based clinician decision support system for diagnosis of inherited retinal diseases: a multicenter, randomized trial | The accurate and timely diagnosis of inherited retinal diseases (IRDs) represents an unmet clinical need in ophthalmology, as the current pathways rely on resource-intensive phenotyping, multidisciplinary expertise and genetic testing. Here we developed Retina4IRD, an artificial intelligence (AI)-based clinician decisi... | Nat Med | Nature medicine | 2026 Jul 24 | 2,026 | [
"Jia H",
"Qian B",
"Qu Y",
"Wang J",
"Chen J",
"Li T",
"Zheng C",
"Han J",
"Zhang G",
"Jin Y",
"Lee S",
"Chen X",
"Chen H",
"Xu J",
"Xu K",
"Rong Y",
"Jiang Y",
"Yang Y",
"Li W",
"Guo Q",
"Li Y",
"Li Y",
"Wu J",
"Zhang Q",
"Lu F",
"Zhuang W",
"Lei B",
"Byeon SH"... | Jia H | Sun X | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42498742/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42498741 | 10.1038/s41591-026-04496-2 | Prospective validation of imaging and serum diagnostic biomarkers of steatohepatitis and fibrosis in MASLD: the LITMUS Imaging Study | There is a need for robust evaluations of noninvasive biomarkers for metabolic dysfunction-associated steatotic liver disease. This prospective multicenter study assessed the diagnostic accuracy of imaging (including liver stiffness measurement (LSM) using magnetic resonance elastography (MRE) and FibroScan (vibration-... | Nat Med | Nature medicine | 2026 Jul 24 | 2,026 | [
"Pavlides M",
"Vali Y",
"Mózes FE",
"Wonders K",
"Akhtar S",
"Hockings PD",
"Shumbayawonda E",
"Pepin K",
"Fernandez-Lizaranzu I",
"Leeming DJ",
"Cobbold JF",
"Allison MED",
"Aithal GP",
"Romero-Gomez M",
"Aller R",
"Pericàs JM",
"Boursier J",
"Petta S",
"Schattenberg JM",
"Eks... | Pavlides M | Anstee QM | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42498741/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42493572 | 10.1038/s41591-026-04563-8 | Early detection of Alzheimer's disease with circular RNA from blood | null | Nat Med | Nature medicine | 2026 Jul 23 | 2,026 | [] | null | null | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42493572/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42493571 | 10.1038/s41591-026-04534-z | Povorcitinib for hidradenitis suppurativa: the randomized, double-blind, placebo-controlled STOP-HS1 and STOP-HS2 phase 3 trials | Although therapeutic options for hidradenitis suppurativa (HS) continue to expand, unmet needs remain substantial. We evaluated the efficacy and safety of povorcitinib (an oral, highly selective Janus kinase 1 (JAK1) inhibitor) in patients with moderate to severe HS in two randomized trials. STOP-HS1 and STOP-HS2 were ... | Nat Med | Nature medicine | 2026 Jul 23 | 2,026 | [
"Porter ML",
"Martorell A",
"Sayed CJ",
"Bechara FG",
"Lev-Tov H",
"Hsiao JL",
"Frew JW",
"Reguiaï Z",
"Gooderham MJ",
"Goldfarb N",
"van der Zee HH",
"Del Marmol V",
"Marzano AV",
"Ehst BD",
"Ackerman LS",
"Hayama K",
"Tian C",
"Kelley J",
"Zhen H",
"Kirby JS",
"Brown K",
... | Porter ML | Zouboulis CC | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42493571/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42487062 | 10.1038/s41591-026-04593-2 | Author Correction: Multi-antigen-targeting T cells in pediatric central nervous system tumors: a phase 1 trial | null | Nat Med | Nature medicine | 2026 Jul 22 | 2,026 | [
"Gomez S",
"DiCioccio RA",
"Geiger AE",
"Grant ML",
"Reynolds E",
"Datar A",
"McCann CD",
"Tanna J",
"Kukadiya D",
"Hoq F",
"Zhang A",
"Hanley PJ",
"Webb JL",
"Kilburn LB",
"Rood BR",
"Fonseca A",
"Meany HJ",
"Vézina LG",
"Packer RJ",
"Cruz CRY",
"Bollard CM",
"Hwang EI"
] | Gomez S | Hwang EI | [] | [
"Published Erratum"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42487062/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42487061 | 10.1038/s41591-026-04522-3 | FcRH5×CD3 bispecific antibody cevostamab in relapsed or refractory multiple myeloma: a phase 1 trial | Fc receptor-homolog 5 (FcRH5) is a membrane protein that is ubiquitously expressed on myeloma cells. Cevostamab is a first-in-class, FcRH5×CD3 bispecific antibody. GO39775 is a phase 1 dose-escalation and dose-expansion study evaluating fixed-duration cevostamab in relapsed or refractory multiple myeloma. Cevostamab wa... | Nat Med | Nature medicine | 2026 Jul 22 | 2,026 | [
"Cohen AD",
"Richter J",
"Trudel S",
"Lesokhin A",
"Laubach JP",
"Thomas SK",
"Harrison SJ",
"Costa LJ",
"Spencer A",
"Fonseca R",
"Forsberg PA",
"Berdeja JG",
"Kaedbey R",
"Bahlis NJ",
"Rodriguez-Otero P",
"Mateos MV",
"Tyagi T",
"Samineni D",
"Liu W",
"Nakamura R",
"Choeurn... | Cohen AD | Krishnan A | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42487061/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42487060 | 10.1038/s41591-026-04535-y | Governing the social production of care: the hidden foundation of health systems | null | Nat Med | Nature medicine | 2026 Jul 22 | 2,026 | [
"Occhipinti JA",
"Prodan A",
"Buchanan J",
"Martin M",
"Khalatbari-Soltani S",
"Swieboda P",
"Eyre H",
"Crosland P",
"Hosseini SH",
"van Zwieten A",
"Samtani S",
"Sawan M",
"Cobos Muñoz D",
"Okamoto S",
"Robinson J",
"Norris D",
"Jeste DV",
"Destrebecq F",
"Heffernan M",
"Tanne... | Occhipinti JA | Miranda JJ | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42487060/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42481853 | 10.1038/s41591-026-04523-2 | Genomas Brasil program: building precision public health within Brazil's Unified Health System | null | Nat Med | Nature medicine | 2026 Jul 21 | 2,026 | [
"Araújo de França GV",
"Lupatini EO",
"Rocha RT",
"Toledo RCP",
"Figueiredo GSF",
"Gonçalves CEI",
"Machado ILO",
"Anzolin AP",
"Gontijo CC",
"Vidal JFD",
"Ramos PIP",
"Carreiro RP",
"Freitas MS",
"De Negri F"
] | Araújo de França GV | De Negri F | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42481853/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42481852 | 10.1038/s41591-026-04536-x | A new additive in the opioid supply is causing disastrous complications | null | Nat Med | Nature medicine | 2026 Jul 21 | 2,026 | [
"Borelli C"
] | Borelli C | Borelli C | [] | [
"Letter"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42481852/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42481851 | 10.1038/s41591-026-04527-y | Individualized antisense oligonucleotides for SCN2A-related developmental epileptic encephalopathy | SCN2A variants are among the most common genetic causes of developmental and epileptic encephalopathies (DEEs), which can present with uncontrolled seizures at birth and account for 1-2% of all epileptic encephalopathies. A substantial fraction of causal variants are gain-of-function or mixed-function variants associat... | Nat Med | Nature medicine | 2026 Jul 21 | 2,026 | [
"Kim-McManus O",
"Mignon L",
"Douville J",
"Pu H",
"Parisien C",
"Glass S",
"Bennett CF",
"Celso J",
"Robbins K",
"Ung H",
"Olson H",
"Kingsmore SF",
"Petrou S",
"Crooke ST",
"Gleeson JG",
"Berry-Kravis E"
] | Kim-McManus O | Berry-Kravis E | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42481851/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42469479 | 10.1038/d41591-026-00037-z | An AI co-scientist to accelerate biomedical research | null | Nat Med | Nature medicine | 2026 Jul 17 | 2,026 | [
"O'Leary K"
] | O'Leary K | O'Leary K | [] | [
"News"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42469479/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42463883 | 10.1038/s41591-026-04498-0 | A neuroprosthesis for restoring hand movement and sensation in a person with complete tetraplegia | Millions of people worldwide are living with movement and sensory impairments owing to spinal cord injury, stroke and other neurological conditions. Here we report a double neural bypass (DNB), a hybrid neuroprosthetic system designed to restore both immediate and lasting gains in movement and sensation after a severe,... | Nat Med | Nature medicine | 2026 Jul | 2,026 | [
"Chandrasekaran S",
"Wandelt SK",
"Jangam A",
"Elias Z",
"Ibroci E",
"Maffei C",
"Rosenthal IA",
"Ramdeo R",
"Kim JW",
"Xu J",
"Glasser MF",
"Neuwirth A",
"Goldstein TA",
"Crone NE",
"Fifer MS",
"Tostaeva G",
"Bickel S",
"Griffin D",
"Funaro M",
"Carras NG",
"Pruitt R",
"Be... | Chandrasekaran S | Bouton CE | [
"Humans",
"Quadriplegia",
"Hand",
"Movement",
"Spinal Cord Injuries",
"Brain-Computer Interfaces",
"Recovery of Function",
"Neural Prostheses",
"Sensation",
"Male",
"Adult"
] | [
"Journal Article",
"Case Reports"
] | 32 | 7 | 2591-2601 | pmc-id: PMC13375563; | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42463883/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42463854 | 10.1038/s41591-026-04581-6 | Author Correction: Integrated community-based HIV and sexual and reproductive health services for youth: a cluster-randomized trial | null | Nat Med | Nature medicine | 2026 Jul 16 | 2,026 | [
"Ferrand RA",
"Dauya E",
"Chikwari CD",
"Bandason T",
"Bernays S",
"Mackworth-Young C",
"Doyle AM",
"Grundy C",
"Indravudh P",
"Terris-Prestholt F",
"Mavodza CV",
"Mugurungi O",
"Apollo T",
"Ncube G",
"Larsson L",
"McCarthy O",
"Simms V",
"Tembo M",
"Kranzer K",
"Hayes RJ"
] | Ferrand RA | Hayes RJ | [] | [
"Published Erratum"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42463854/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42463853 | 10.1038/s41591-026-04569-2 | Author Correction: Evolution of claudin18.2 therapies in gastroesophageal cancers | null | Nat Med | Nature medicine | 2026 Jul 16 | 2,026 | [
"Klempner SJ",
"Sundar R"
] | Klempner SJ | Sundar R | [] | [
"Published Erratum"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42463853/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42463852 | 10.1038/s41591-026-04533-0 | Englumafusp alfa plus glofitamab in B cell non-Hodgkin lymphoma: a phase 1 trial | There is an unmet need for effective, off-the-shelf therapies for relapsed or refractory aggressive B cell non-Hodgkin lymphoma (B-NHL). Part 2 of the current study was an open-label, nonrandomized, phase 1 study of escalating doses of the CD19-4-1BBL co-stimulatory molecule, englumafusp alfa, in combination with glofi... | Nat Med | Nature medicine | 2026 Jul 16 | 2,026 | [
"Hutchings M",
"Dickinson M",
"Gritti G",
"Carlo-Stella C",
"Townsend W",
"Bosch F",
"Bartlett NL",
"Cartron G",
"Ghesquieres H",
"Houot R",
"Walter H",
"Offner F",
"Dimier N",
"Jamois C",
"Herter S",
"Keelara A",
"Wilson S",
"Gallien J",
"Hinton H",
"Gonzalez-Albo IP",
"Korf... | Hutchings M | Morschhauser F | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42463852/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42463498 | 10.1038/d41591-026-00036-0 | Mining antigens for a universal malaria vaccine | null | Nat Med | Nature medicine | 2026 Jul 16 | 2,026 | [
"O'Leary K"
] | O'Leary K | O'Leary K | [] | [
"News"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42463498/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42458038 | 10.1038/d41591-026-00035-1 | A turning point for gene editing in severe blood disorders | null | Nat Med | Nature medicine | 2026 Jul 15 | 2,026 | [
"Arnold C"
] | Arnold C | Arnold C | [] | [
"News"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42458038/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42458012 | 10.1038/s41591-026-04547-8 | Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial | While Alzheimer's disease (AD) is initiated by amyloid plaque accumulation, its progression involves local neuroinflammation that the brain cannot resolve when age-related dysfunction of the systemic immune system limits peripheral immune support. Preclinical studies using rodent models showed that transient systemic b... | Nat Med | Nature medicine | 2026 Jul 15 | 2,026 | [
"Croese T",
"Mummery CJ",
"Bregman N",
"Bracha D",
"Baruch K",
"Kertser A",
"Raveh S",
"Shochat E",
"Schwartz M"
] | Croese T | Schwartz M | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42458012/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42458011 | 10.1038/s41591-026-04515-2 | Multi-omics maps human-pig interactions in extracorporeal liver cross-circulation | null | Nat Med | Nature medicine | 2026 Jul 15 | 2,026 | [] | null | null | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42458011/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42458010 | 10.1038/s41591-026-04507-2 | Fertilizer scarcity as a failure of global health governance | null | Nat Med | Nature medicine | 2026 Jul 15 | 2,026 | [
"Nasari A",
"Nasari A",
"Marzouk S",
"Prasad T",
"Fanzo J"
] | Nasari A | Fanzo J | [] | [
"Letter"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42458010/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42458009 | 10.1038/s41591-026-04520-5 | Studying vanishing dietary diversity before it is lost: the World Diet Initiative | null | Nat Med | Nature medicine | 2026 Jul 15 | 2,026 | [
"de Mast Q",
"Brown CV",
"Mwakasungura F",
"Nakanjako D",
"Temba GS",
"Kumar V",
"Pramono A",
"Crișan TO",
"Riza A",
"de Jonge MI",
"Wagner N",
"Hoentjen F",
"Ferreira AVM",
"Chakraborty A",
"Teixeira M",
"Fekadu A",
"Xavier RJ",
"Sunguya B",
"Netea MG"
] | de Mast Q | Netea MG | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42458009/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42458008 | 10.1038/s41591-026-04526-z | When caution becomes harm | null | Nat Med | Nature medicine | 2026 Jul 15 | 2,026 | [
"Vigod SN"
] | Vigod SN | Vigod SN | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42458008/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42458007 | 10.1038/s41591-026-04491-7 | Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial | Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease partly caused by gain-of-function mutations in superoxide dismutase 1 (SOD1). Here we developed RAG-17, an siRNA-targeting SOD1, using an accessory oligonucleotide conjugate platform for enhanced central nervous system (CNS) delivery. Preclinicall... | Nat Med | Nature medicine | 2026 Jul | 2,026 | [
"Chen W",
"Jiang L",
"Duan C",
"Kang M",
"Ye J",
"Wang L",
"Pan Y",
"Qu H",
"Liao X",
"Zhou X",
"Li Y",
"Gan Z",
"Chen J",
"Schacht I",
"Place RF",
"Li LC",
"Wang Y"
] | Chen W | Wang Y | [
"Amyotrophic Lateral Sclerosis",
"Humans",
"Animals",
"Superoxide Dismutase-1",
"Female",
"Male",
"RNA, Small Interfering",
"Oligonucleotides",
"Macaca fascicularis",
"Middle Aged",
"Aged",
"Adult",
"Motor Neurons"
] | [
"Journal Article",
"Clinical Trial, Phase I"
] | 32 | 7 | 2619-2628 | pmc-id: PMC13375534; | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42458007/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42443516 | 10.1038/s41591-026-04570-9 | Author Correction: The STARD-AI reporting guideline for diagnostic accuracy studies using artificial intelligence | null | Nat Med | Nature medicine | 2026 Jul 13 | 2,026 | [
"Sounderajah V",
"Guni A",
"Liu X",
"Collins GS",
"Karthikesalingam A",
"Markar SR",
"Golub RM",
"Denniston AK",
"Shetty S",
"Moher D",
"Bossuyt PM",
"Darzi A",
"Ashrafian H",
"STARD-AI Steering Committee"
] | Sounderajah V | Ashrafian H | [] | [
"Published Erratum"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42443516/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42443515 | 10.1038/s41591-026-04518-z | An anti-PMEL antibody-drug conjugate with a G(q/1)(1) inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial | Metastatic uveal melanoma (mUM) is an aggressive cancer with limited treatment options; 85-90% of tumors harbor activating GNAQ and GNA11 mutations. Uveal melanoma cells also express PMEL (also known as PMEL17 or gp100), a melanocyte lineage antigen. DYP688, a novel biology-matched antibody-drug conjugate, binds surfac... | Nat Med | Nature medicine | 2026 Jul 13 | 2,026 | [
"Carlino MS",
"Kapiteijn E",
"Piperno-Neumann S",
"Sullivan RJ",
"Carvajal R",
"Dummer R",
"Gromke T",
"Hassel JC",
"Kee D",
"Ramelyte E",
"Shoushtari AN",
"Wei AZ",
"Enk A",
"Handel EE",
"Montazeri K",
"Ramon-Patino J",
"Richly H",
"Rodrigues M",
"Sandhu S",
"Smithy J",
"Spe... | Carlino MS | Calvo E | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42443515/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42432293 | 10.1038/s41591-026-04475-7 | Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial | Lymphocyte activation gene 3 (LAG-3) is an immune checkpoint implicated in T cell exhaustion and a potential therapeutic target in glioblastoma (GBM). We conducted a multicenter, open-label, phase 1 study with sequential allocation to evaluate the safety and preliminary activity of the anti-LAG-3 antibody relatlimab, a... | Nat Med | Nature medicine | 2026 Jul | 2,026 | [
"Lim M",
"Ye X",
"Piotrowski AF",
"Desai A",
"Ahluwalia MS",
"Walbert T",
"Lesser G",
"Ellingson BM",
"Peereboom DM",
"Fisher JD",
"Desideri S",
"Jackson C",
"Pant A",
"Jain A",
"Verma R",
"Oberlton B",
"Piyadasa H",
"Bettegowda C",
"Engle L",
"Taube J",
"Bendall SC",
"Choi... | Lim M | Grossman SA | [
"Humans",
"Glioblastoma",
"Female",
"Lymphocyte Activation Gene 3 Protein",
"Male",
"Middle Aged",
"Programmed Cell Death 1 Receptor",
"Aged",
"Adult",
"Antigens, CD",
"Neoplasm Recurrence, Local",
"Nivolumab",
"Brain Neoplasms",
"CD8-Positive T-Lymphocytes",
"Antibodies, Monoclonal, Hum... | [
"Journal Article",
"Clinical Trial, Phase I",
"Multicenter Study"
] | 32 | 7 | 2449-2460 | pmc-id: PMC13375532; | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42432293/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42432292 | 10.1038/s41591-026-04497-1 | Health system learning enables generalist neuroimaging models | Frontier artificial intelligence (AI) models have advanced rapidly through training on internet-scale public data, yet such systems lack access to private clinical data. Neuroimaging is underrepresented in the public domain due to identifiable facial features within magnetic resonance imaging (MRI) and computed tomogra... | Nat Med | Nature medicine | 2026 Jul 10 | 2,026 | [
"Kondepudi A",
"Rao A",
"Zhao C",
"Lyu Y",
"Harake S",
"Banerjee S",
"Ogle J",
"Joshi R",
"Meissner AK",
"Hou X",
"Jiang C",
"Chowdury A",
"Srinivasan A",
"Athey B",
"Gulani V",
"Pandey A",
"Lee H",
"Hollon T"
] | Kondepudi A | Hollon T | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42432292/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42426224 | 10.1038/s41591-026-04538-9 | KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRAS(G12D)-mutant pancreatic cancer: a phase 1b/2 trial | KRASG12D is the predominant oncogenic driver in pancreatic ductal adenocarcinoma (PDAC). While most investigational KRAS-G12D inhibitors are oral small molecules limited by gastrointestinal toxicities and suboptimal tumor exposure, HRS-4642 is a new, high‑affinity, noncovalent KRAS-G12D inhibitor. Formulated as a lipos... | Nat Med | Nature medicine | 2026 Jul 9 | 2,026 | [
"Cui J",
"Jiang K",
"Li W",
"Ni S",
"Zong H",
"Du J",
"He Y",
"Liu Z",
"Kong G",
"Zhang Y",
"Li X",
"Han H",
"Yao F",
"Chen Y",
"Zhou M",
"Wang L"
] | Cui J | Wang L | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42426224/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
42426223 | 10.1038/s41591-026-04525-0 | Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial | Parkinson's disease (PD) is characterized by progressive loss of nigral dopaminergic neurons, resulting in disabling motor symptoms. Intracerebral transplantation of stem cell-derived dopaminergic progenitors to replace lost endogenous dopaminergic neurons offers a new potentially restorative therapeutic approach for P... | Nat Med | Nature medicine | 2026 Jul 9 | 2,026 | [
"Paul G",
"Bjartmarz H",
"Kirkeby A",
"Nelander J",
"Smith R",
"Kayhanian S",
"Evans A",
"Harry B",
"Cutting E",
"Fazal S",
"Lao-Kaim NP",
"van Vliet T",
"Ullén S",
"Grubor I",
"Hansson O",
"Piccini P",
"Lindvall O",
"Björklund A",
"Widner H",
"Parmar M",
"Barker RA"
] | Paul G | Barker RA | [] | [
"Journal Article"
] | null | null | null | null | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/42426223/ | r9GDF8oUQxUgnesSn | XPdoULSRbkZbN0WmB |
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