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42462008 | 10.1126/science.aed6123 | Structure and evolution-guided design of minimal RNA-guided nucleases | The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic properties remains challenging. Here, we use a protein design strategy that couples a structure-guided inverse-folding m... | Science | Science (New York, N.Y.) | 2026 Jul 16 | 2,026 | [
"Skopintsev P",
"Esain-Garcia I",
"DeTurk EC",
"Yoon PH",
"Zhou Z",
"Weiss T",
"Kamalu M",
"Chamraj A",
"Loi KJ",
"Langeberg CJ",
"Boger RS",
"Nisonoff H",
"Karp HM",
"Chen LX",
"Shi H",
"Vohra K",
"Banfield JF",
"Cate JHD",
"Jacobsen SE",
"Doudna JA"
] | Skopintsev P | Doudna JA | [
"Humans",
"CRISPR-Cas Systems",
"Cryoelectron Microscopy",
"Directed Molecular Evolution",
"DNA",
"Gene Editing",
"Models, Molecular",
"Protein Conformation",
"Protein Engineering",
"RNA",
"RNA, Guide, CRISPR-Cas Systems",
"Bacterial Proteins",
"Endodeoxyribonucleases",
"CRISPR-Associated ... | [
"Journal Article"
] | 393 | 6808 | 313-318 | null | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/42462008/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
42395396 | 10.64898/2026.06.21.729417 | Programming T cells for intercellular genome editing | Therapeutic genome editing requires delivery of editing molecules to defined cell types, but targeting specificity and efficiency are currently limited. We hypothesized that properties inherent to immune cells, including tissue infiltration and programmed cell recognition, could be harnessed to engineer a cell-based de... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Jun 23 | 2,026 | [
"Wasko KM",
"Maker M",
"Ngo W",
"Chen K",
"Ma E",
"Pattali R",
"Chen E",
"Leung T",
"Braverman J",
"Doudna JA"
] | Wasko KM | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC13320803; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/42395396/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
42387168 | 10.1038/s41586-026-10621-5 | Harmonizing standards and resources for the medical genome | Realizing the promise of precision medicine will require the highest standards of accuracy in genome sequencing and analysis. Here we describe challenges and opportunities for the field through the lens of genome data quality. We present recommendations in the context of specific areas of application for genomic sequen... | Nature | Nature | 2026 Jul | 2,026 | [
"Ashley EA",
"Alizadeh AA",
"Armitage H",
"Bhatt AS",
"Blumenfeld Y",
"Carroll A",
"Chavez RM",
"Giannikopoulos P",
"Grove ME",
"Halley MC",
"Khush K",
"Lennon NJ",
"Maragh S",
"Marson A",
"Paten B",
"Phillippy AM",
"Porteus MH",
"Rehm HL",
"Ringeisen BR",
"Salzman J",
"Schne... | Ashley EA | Doudna JA | [
"Humans",
"Genome, Human",
"Genomics",
"Neoplasms",
"Precision Medicine",
"Quality Control",
"Sequence Analysis, DNA"
] | [
"Journal Article"
] | 655 | 8121 | 47-58 | null | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/42387168/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
42315922 | 10.1038/s41587-026-03221-1 | Publisher Correction: Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein | null | Nat Biotechnol | Nature biotechnology | 2026 Jul | 2,026 | [
"Chen K",
"Han H",
"Zhao S",
"Xu B",
"Yin B",
"Lawanprasert A",
"Trinidad M",
"Burgstone BW",
"Murthy N",
"Doudna JA"
] | Chen K | Doudna JA | [] | [
"Published Erratum"
] | 44 | 7 | 1238 | pmc-id: PMC13368578; | 1087-0156 | eng | https://pubmed.ncbi.nlm.nih.gov/42315922/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
42259916 | 10.1038/s41586-026-10738-7 | Targeting cancer-specific mutations with RNA-triggered chromatin shredding | Genetic mutations that drive cancer often occur in tumour-suppressor proteins such as the p53 transcription factor, which is altered in 40-50% of cases1,2. However, current therapies often fail to target these mutations because the mutant proteins typically lack defined drug-binding pockets and restoring their endogeno... | Nature | Nature | 2026 Jun 8 | 2,026 | [
"Zeng J",
"Cheng Z",
"Chen H",
"Wang Z",
"Thompson J",
"Crosby KT",
"Han H",
"Singhal A",
"Ngo W",
"Xia C",
"Rosas-Rivera D",
"Zhang Z",
"Kang MH",
"Mao Y",
"Diolaiti ME",
"Lee GC",
"Diffley JFX",
"Song Y",
"Qiu L",
"Krah NM",
"Murthy N",
"Jackson RN",
"Liu Y",
"Ashwort... | Zeng J | Doudna JA | [] | [
"Journal Article"
] | null | null | null | null | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/42259916/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
42146678 | 10.64898/2026.05.08.723607 | Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding | Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ~40-50% of cases1,2. However, current therapies fail to target most such mutations because the mutant proteins typically lack defined drug-binding pockets, and restoring the endogenou... | bioRxiv | bioRxiv : the preprint server for biology | 2026 May 9 | 2,026 | [
"Zeng J",
"Cheng Z",
"Chen H",
"Thompson J",
"Crosby KT",
"Han H",
"Ngo W",
"Xia C",
"Rosas-Rivera D",
"Kang MH",
"Mao Y",
"Lee G",
"Diffley JFX",
"Song Y",
"Qiu L",
"Krah NM",
"Murthy N",
"Jackson RN",
"Liu Y",
"Ashworth A",
"Doudna JA"
] | Zeng J | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC13174608; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/42146678/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
42094414 | 10.64898/2026.04.26.720920 | A Noncontiguous Code for RNA-Guided DNA Recognition Preceded CRISPR | CRISPR-Cas systems use RNA-guided proteins for adaptive immunity through a mechanism whose origin is unknown. Here we report the discovery of Viral Interference Programmable Repeat (VIPR) systems consisting of a Vipr protein more ancient than CRISPR-Cas and vrRNAs comprising alternating GGY/NN motifs. Unlike canonical ... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Jun 25 | 2,026 | [
"Yoon PH",
"Loi K",
"Zhang Z",
"Docter TA",
"Lopez SC",
"Langeberg CJ",
"Moezur-Rehman M",
"Vohra K",
"Zhou Z",
"Shi H",
"Boger R",
"Wang PY",
"Adler BA",
"Brohawn SG",
"Doudna JA"
] | Yoon PH | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC13142463; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/42094414/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41961593 | 10.1016/j.celrep.2026.117219 | The phage nucleus synergizes with an anti-defense protein to resist bacterial immunity | Chimallivirus bacteriophages enclose their replicating genomes in a protein-based compartment termed the phage nucleus. While the phage nucleus segregates phage DNA from host immune proteins, it is not known if additional factors are required to protect against DNA-targeting host defenses. Here, we identify a chimalliv... | Cell Rep | Cell reports | 2026 Apr 8 | 2,026 | [
"Morgan CJ",
"Rani P",
"Deep A",
"Liu R",
"Basu D",
"Chambers LR",
"Li YX",
"Levine M",
"Hsieh K",
"Adler BA",
"Birkholz E",
"Doudna JA",
"Villa E",
"Corbett KD",
"Pogliano J"
] | Morgan CJ | Pogliano J | [] | [
"Journal Article"
] | 45 | 4 | 117219 | pmc-id: PMC13309987;manuscript-id: NIHMS2170791; | 2211-1247 | eng | https://pubmed.ncbi.nlm.nih.gov/41961593/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41917196 | 10.1038/s41551-026-01642-6 | Programmable kinetic barcoding for multiplexed RNA detection with Cas13a | Rapid identification of viral infections and specific variants in patient samples requires a simple and multiplexed RNA detection method that does not rely on DNA sequencing. Although recent direct detection assays based on CRISPR-Cas13a offer rapid RNA detection by avoiding reverse transcription and DNA amplification ... | Nat Biomed Eng | Nature biomedical engineering | 2026 Mar 31 | 2,026 | [
"Son S",
"Lyden A",
"Ng CF",
"Dextre A",
"Shu J",
"Stephens SI",
"Fozouni P",
"Knott GJ",
"Smock DCJ",
"Liu TY",
"Boehm D",
"Simoneau C",
"Kumar GR",
"Doudna JA",
"Ott M",
"Fletcher DA"
] | Son S | Fletcher DA | [] | [
"Journal Article"
] | null | null | null | null | 2157-846X | eng | https://pubmed.ncbi.nlm.nih.gov/41917196/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41867802 | 10.64898/2026.03.06.709984 | Spligation enables programmable chimeric RNA generation in living cells | The ability to precisely modify RNA offers opportunities to manipulate the flow of genetic information and influence transcript stability, localization and translation. RNA-targeting technologies enable RNA knockdown, base editing and trans-splicing, but more extensive transcript changes typically require genome editin... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Mar 6 | 2,026 | [
"Colognori DA",
"Wasko KM",
"Trinidad MI",
"Zhou Z",
"Doudna JA"
] | Colognori DA | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC13001472; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41867802/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41851456 | 10.1038/s41586-026-10235-x | In vivo site-specific engineering to reprogram T cells | Engineered T cells, reprogrammed to express chimeric antigen receptors (CAR) or T cell receptors (TCR), have transformed cancer treatment and are being explored as therapeutics for autoimmune and infectious diseases. Enhancing T cell function through genome editing, either by disrupting endogenous genes or precisely in... | Nature | Nature | 2026 Apr | 2,026 | [
"Nyberg WA",
"Bernard PL",
"Ngo W",
"Wang CH",
"Ark J",
"Rothrock A",
"Borgo GM",
"Kimmerly GR",
"Jung JH",
"Allain V",
"Hamilton JR",
"Baldwin A",
"Stickels R",
"Wyman S",
"Khan SH",
"Lang S",
"Marsh D",
"Almudhfar N",
"Novick C",
"Mortazavi Y",
"Zhang S",
"AbdElwakil MM",... | Nyberg WA | Eyquem J | [
"Animals",
"Mice",
"T-Lymphocytes",
"Receptors, Chimeric Antigen",
"CRISPR-Cas Systems",
"Humans",
"Transgenes",
"Gene Editing",
"Dependovirus",
"Female",
"Cellular Reprogramming",
"Genetic Vectors",
"Cell Engineering",
"Immunotherapy, Adoptive",
"Male"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 652 | 8110 | 712-721 | pmc-id: PMC13083257; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/41851456/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41841630 | 10.1111/pbi.70644 | Efficient Transgene-Free Multiplexed Germline Editing via Viral Delivery of an Engineered TnpB | null | Plant Biotechnol J | Plant biotechnology journal | 2026 Jun | 2,026 | [
"Weiss T",
"Kamalu M",
"Shi H",
"Wirnowski G",
"Ingelsson A",
"Amerasekera J",
"Vohra K",
"Trinidad MI",
"Li Z",
"Freitas E",
"Steinmetz N",
"Ambrose C",
"Chen K",
"Doudna JA",
"Jacobsen SE"
] | Weiss T | Jacobsen SE | [] | [
"Journal Article"
] | 24 | 6 | 4358-4360 | pmc-id: PMC13205730; | 1467-7644 | eng | https://pubmed.ncbi.nlm.nih.gov/41841630/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41814095 | 10.1038/s41587-026-03059-7 | Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning | TnpB is a diverse family of RNA-guided endonucleases associated with prokaryotic transposons. Because of their small size and putative evolutionary relationship to CRISPR-Cas12, TnpB enzymes hold great potential for genome editing. However, most TnpBs lack robust gene-editing activity. Here, we mapped comprehensive seq... | Nat Biotechnol | Nature biotechnology | 2026 Mar 11 | 2,026 | [
"Thornton BW",
"Weissman RF",
"Rodriguez JE",
"Tran RV",
"Duong BT",
"Terrace CI",
"Nagalakshmi U",
"Austin G",
"Groover ED",
"Wang FZ",
"Park JU",
"Georgieva V",
"Tartaglia J",
"Cho MJ",
"Dinesh-Kumar SP",
"Doudna JA",
"Savage DF"
] | Thornton BW | Savage DF | [] | [
"Journal Article"
] | null | null | null | null | 1087-0156 | eng | https://pubmed.ncbi.nlm.nih.gov/41814095/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41676649 | 10.1101/2024.03.05.583578 | Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants | The open reading frame 8 (ORF8), an accessory protein of SARS-CoV-2, is prone to deletions and mutations across different viral variants, which was first described in several Singapore variants. The reason why viral evolution favors loss or inactivation of ORF8 is not fully understood, although the effects of ORF8 on i... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Feb 3 | 2,026 | [
"Khalid MM",
"Chen IP",
"Soveg FS",
"Taha TY",
"Tabata T",
"Suryawanshi RK",
"Syed AM",
"Ciling A",
"McCavitt-Malvido M",
"Schulze-Gahmen U",
"Hayashi J",
"Kim IJ",
"Fong SW",
"Batra J",
"Kumar GR",
"Renia L",
"Ng LF",
"Krogan NJ",
"Doudna JA",
"Verdin E",
"Ott M"
] | Khalid MM | Ott M | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12889891; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41676649/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41648602 | 10.64898/2026.01.13.699115 | Amplified genome editing by in vivo editor production | Genome editing enzymes have vast therapeutic potential. However, achieving sufficient delivery in vivo remains a major challenge, because editing machinery is confined to the subset of transfectable cells in a tissue. Here, we tested the possibility that genome editing could be amplified in vivo by programming transfec... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Jan 13 | 2,026 | [
"Ngo W",
"Rosas-Rivera D",
"Wasko KM",
"Qiu L",
"Kang MH",
"Gogna S",
"Zeng J",
"Hooks MT",
"Wu JLY",
"Li Z",
"Doudna JA"
] | Ngo W | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12871335; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41648602/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41648250 | 10.64898/2026.01.23.700382 | Efficient transgene-free multiplexed germline editing via viral delivery of an engineered TnpB | Virus-induced genome editing (VIGE) using compact RNA-guided endonucleases is a transformational new approach in plant biotechnology, enabling tissue-culture-independent and transgene-free genome editing (Hu et al. 2025; Liu et al. 2025; Weiss et al. 2025). We recently established a VIGE approach for heritable editing ... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Feb 25 | 2,026 | [
"Weiss T",
"Kamalu M",
"Shi H",
"Wirnowski G",
"Ingelsson A",
"Amerasekera J",
"Vohra K",
"Trinidad MI",
"Li Z",
"Freitas E",
"Steinmetz N",
"Ambrose C",
"Chen K",
"Doudna JA",
"Jacobsen SE"
] | Weiss T | Jacobsen SE | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12871731; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41648250/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41573840 | 10.64898/2025.12.08.692503 | Structure and evolution-guided design of minimal RNA-guided nucleases | The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome editing capabilities. However, generating diverse multi-domain proteins with robust enzymatic properties remains challenging. Here we use an artificial intelligence-driven strategy that couples structure-guided in... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Dec 8 | 2,025 | [
"Skopintsev P",
"Esain-Garcia I",
"DeTurk EC",
"Yoon PH",
"Zhou Z",
"Weiss T",
"Kamalu M",
"Chamraj A",
"Loi KJ",
"Langeberg CJ",
"Boger R",
"Nisonoff H",
"Karp HM",
"Chen L",
"Shi H",
"Vohra K",
"Banfield JF",
"Cate JHD",
"Jacobsen SE",
"Doudna JA"
] | Skopintsev P | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12822741; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41573840/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41542533 | 10.64898/2026.01.09.698545 | Stepwise DNA unwinding gates TnpB genome-editing activity | TnpB is a compact RNA-guided endonuclease and evolutionary ancestor of CRISPR-Cas12 that offers a promising platform for genome engineering. However, the genome-editing activity of TnpBs remains limited and its underlying determinants are poorly understood. Here, we used biochemical and single-molecule assays to examin... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Jan 9 | 2,026 | [
"Zhou Z",
"Saffarian-Deemyad I",
"Shi H",
"Weiss T",
"Ur-Rehman MM",
"Vohra K",
"Skopintsev P",
"Yoon PH",
"Trinidad MI",
"Langeberg CJ",
"Kamalu M",
"Amerasekera J",
"Doherty EE",
"Aris KDP",
"Al-Sayyad N",
"Thornton BW",
"Weissman RF",
"Wasko KM",
"Esain-Garcia I",
"DeTurk EC... | Zhou Z | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12803034; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41542533/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41526513 | 10.1038/s41587-025-02945-w | Targeted delivery of genome editors in vivo | Genome editing has revolutionized the treatment of genetic diseases, yet the difficulty of tissue-specific delivery currently limits applications of editing technology. In this Review, we discuss preclinical and clinical advances in delivering genome editors with both established and emerging delivery mechanisms. Targe... | Nat Biotechnol | Nature biotechnology | 2026 Jan | 2,026 | [
"Ngo W",
"Wu JLY",
"Wasko KM",
"Doudna JA"
] | Ngo W | Doudna JA | [
"Humans",
"Gene Editing",
"Animals",
"Genetic Therapy",
"Gene Transfer Techniques",
"CRISPR-Cas Systems"
] | [
"Journal Article",
"Review"
] | 44 | 1 | 49-59 | pmc-id: PMC12875382;manuscript-id: NIHMS2132861; | 1087-0156 | eng | https://pubmed.ncbi.nlm.nih.gov/41526513/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41477825 | 10.1126/sciadv.aea1429 | Identification of proteins influencing CRISPR-associated transposases for enhanced genome editing | CRISPR-associated transposases (CASTs) hold tremendous potential for microbial genome editing because of their ability to integrate large DNA cargos in a programmable, site-specific manner. However, their widespread application has been hindered by poorly understood host factor requirements for transposition. To addres... | Sci Adv | Science advances | 2026 Jan 2 | 2,026 | [
"Song LCT",
"Alker ATP",
"Oromí-Bosch A",
"Swartz SE",
"Martinson JNV",
"Arora J",
"Wang AM",
"Rovinsky R",
"Smith SJ",
"Pierce EC",
"Deutschbauer AM",
"Doudna JA",
"Cress BF",
"Rubin BE"
] | Song LCT | Rubin BE | [
"Gene Editing",
"Transposases",
"Escherichia coli",
"Vibrio cholerae",
"CRISPR-Cas Systems",
"Genome, Bacterial",
"CRISPR-Associated Proteins"
] | [
"Journal Article"
] | 12 | 1 | eaea1429 | pmc-id: PMC12757027; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/41477825/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41415457 | 10.64898/2025.12.14.692434 | Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells | Primary human myeloid cells are promising candidates for immunotherapy, yet efficient and scalable technologies for genetic engineering and screening in these cells are limited. Here we present a virus-like particle (VLP)-based toolkit that delivers diverse CRISPR genome editing modalities to human monocytes, macrophag... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Dec 14 | 2,025 | [
"Jung H",
"Devant P",
"Ching C",
"Ota M",
"Hamilton J",
"Steinhart Z",
"Ngo W",
"Sandoval L",
"Jung JH",
"Xu D",
"An M",
"Urs E",
"Chen PA",
"Allain V",
"Tada T",
"Nuñez JK",
"Landau NR",
"Liu DR",
"Eyquem J",
"Doudna JA",
"Marson A",
"Carnevale J"
] | Jung H | Carnevale J | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12710740; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41415457/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41297541 | 10.1016/j.chom.2025.10.018 | Divergent viral phosphodiesterases for immune signaling evasion | Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase (PDE)-mediated oligonucleotide cleavage for immune evasion, a strategy whose diversity has not yet been explored. Here,... | Cell Host Microbe | Cell host & microbe | 2025 Dec 10 | 2,025 | [
"Doherty EE",
"Nomburg J",
"Adler BA",
"Lopez S",
"Hsieh K",
"Price N",
"Blount N",
"Doudna JA"
] | Doherty EE | Doudna JA | [
"Immune Evasion",
"Phosphoric Diester Hydrolases",
"Signal Transduction",
"Humans",
"Substrate Specificity",
"Viruses",
"Catalytic Domain",
"Viral Proteins"
] | [
"Journal Article"
] | 33 | 12 | 2043-2051.e6 | pmc-id: PMC12730640;manuscript-id: NIHMS2124763; | 1931-3128 | eng | https://pubmed.ncbi.nlm.nih.gov/41297541/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41254216 | 10.1038/s41589-025-02076-y | Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap | Photoproximity labeling proteomics (PLP) methods have recently shown that cell surface receptors can form lateral interactome networks. Here, we present a paired set of PLP workflows that dynamically track neighborhood changes for oncogenic epidermal growth factor receptor (EGFR) over time, both outside and inside of c... | Nat Chem Biol | Nature chemical biology | 2026 Feb | 2,026 | [
"Lin Z",
"Ngo W",
"Chou YT",
"Wu H",
"Susa KJ",
"Jun YW",
"Bivona TG",
"Doudna JA",
"Wells JA"
] | Lin Z | Wells JA | [
"ErbB Receptors",
"Humans",
"Ligands",
"Proteomics",
"Signal Transduction",
"Epidermal Growth Factor",
"Phosphorylation",
"Staining and Labeling"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 22 | 2 | 192-204 | pmc-id: PMC12858401; | 1552-4450 | eng | https://pubmed.ncbi.nlm.nih.gov/41254216/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41249169 | 10.1038/s41467-025-66058-3 | Characterizing and controlling CRISPR repair outcomes in nondividing human cells | Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control of DNA repair outcomes hinders its therapeutic potential. DNA repair is especially understudied in nondividing cells like neurons, limiting the efficiency and precision of genome editing in many clinically releva... | Nat Commun | Nature communications | 2025 Nov 17 | 2,025 | [
"Ramadoss GN",
"Namaganda SJ",
"Kumar MM",
"Hamilton JR",
"Sharma R",
"Chow KG",
"Workley LA",
"Macklin BL",
"Sun M",
"Ha AS",
"Liu JC",
"Fellmann C",
"Watry HL",
"Dierks PH",
"Bose RS",
"Jin J",
"Perez BS",
"Sandoval Espinoza CR",
"Matia MP",
"Lu SH",
"Judge LM",
"Shy BR",... | Ramadoss GN | Conklin BR | [
"Humans",
"Induced Pluripotent Stem Cells",
"Gene Editing",
"DNA Repair",
"CRISPR-Cas Systems",
"Neurons",
"Myocytes, Cardiac",
"DNA Damage",
"T-Lymphocytes"
] | [
"Journal Article"
] | 16 | 1 | 9883 | pmc-id: PMC12623481; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/41249169/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41231971 | 10.1126/science.aea8769 | Recurrent acquisition of nuclease-protease pairs in antiviral immunity | Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin-like protease repeatedly acquired by multiple, otherwise unrelated antiviral immune systems in bacteria. Cell-based and... | Science | Science (New York, N.Y.) | 2026 Jan 8 | 2,026 | [
"Tuck OT",
"Hu JJ",
"Lopez SC",
"Adler BA",
"O'Brien CE",
"Hsieh K",
"Meredith C",
"Loi KJ",
"Yoon PH",
"Doherty EE",
"Lahiri A",
"Doudna JA"
] | Tuck OT | Doudna JA | [
"Bacteria",
"Bacterial Proteins",
"Caspases",
"Deoxyribonucleases",
"DNA Cleavage",
"Evolution, Molecular",
"Peptide Hydrolases",
"Proteolysis",
"Bacteriophages"
] | [
"Journal Article"
] | 391 | 6781 | 195-201 | pmc-id: PMC12799240;manuscript-id: NIHMS2127989; | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/41231971/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
41034576 | 10.1038/s41586-025-09569-9 | A miniature CRISPR-Cas10 enzyme confers immunity by inhibitory signalling | Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signalling that share mechanistic features with human antiviral systems1. In these pathways, including cyclic oligonucleotide-based antiphage signalling systems (CBASSs) and type III CRISPR systems in bacteria and cyclic GMP-AMP ... | Nature | Nature | 2025 Nov | 2,025 | [
"Doherty EE",
"Adler BA",
"Yoon PH",
"Hsieh K",
"Loi K",
"Armbruster EG",
"Lahiri A",
"Bolling CS",
"Wilcox XE",
"Akkati A",
"Iavarone AT",
"Pogliano J",
"Doudna JA"
] | Doherty EE | Doudna JA | [
"Humans",
"Adenylyl Cyclases",
"Cell Death",
"CRISPR-Cas Systems",
"Dinucleoside Phosphates",
"HEK293 Cells",
"Immune Evasion",
"Membrane Proteins",
"Models, Molecular",
"Oligonucleotides",
"Signal Transduction",
"STING Protein"
] | [
"Journal Article",
"Research Support, U.S. Gov't, P.H.S.",
"Research Support, U.S. Gov't, Non-P.H.S.",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural"
] | 647 | 8091 | 997-1004 | pmc-id: PMC12657230;manuscript-id: NIHMS2117476; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/41034576/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40894598 | 10.1101/2025.08.21.671373 | Divergent viral phosphodiesterases for immune signaling evasion | Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase-mediated oligonucleotide cleavage for immune evasion, a strategy whose diversity has not yet been explored. We used a c... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Aug 21 | 2,025 | [
"Doherty EE",
"Nomburg J",
"Adler BA",
"Lopez S",
"Hsieh K",
"Price N",
"Blount N",
"Doudna JA"
] | Doherty EE | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12393533; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/40894598/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40766668 | 10.1101/2025.07.28.667249 | Recurrent acquisition of nuclease-protease pairs in antiviral immunity | Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin-like protease repeatedly acquired by multiple, otherwise unrelated antiviral immune systems in bacteria. Cell-based and... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Jul 28 | 2,025 | [
"Tuck OT",
"Hu JJ",
"Adler BA",
"O'Brien CE",
"Lopez SC",
"Hsieh K",
"Meredith C",
"Lahiri A",
"Doherty EE",
"Doudna JA"
] | Tuck OT | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12324324; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/40766668/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40711918 | 10.1073/pnas.2504853122 | Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing | Phage λ, a well-characterized temperate phage, has been recently leveraged for bacterial genome editing by selectively delivering base editors into targeted bacterial species. We extend this concept by engineering phage λ to deliver CRISPR-guided transposases, accomplishing large insertions and targeted gene disruption... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2025 Jul 29 | 2,025 | [
"Roberts A",
"Adler BA",
"Cress BF",
"Doudna JA",
"Barrangou R"
] | Roberts A | Barrangou R | [
"Gene Editing",
"Transposases",
"CRISPR-Cas Systems",
"Escherichia coli",
"Bacteriophage lambda",
"Genome, Bacterial"
] | [
"Journal Article"
] | 122 | 30 | e2504853122 | pmc-id: PMC12318184; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/40711918/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40671523 | 10.1093/nar/gkaf649 | Directed evolution expands CRISPR-Cas12a genome-editing capacity | CRISPR-Cas12a enzymes are versatile RNA-guided genome-editing tools with applications encompassing viral diagnosis, agriculture, and human therapeutics. However, their dependence on a 5'-TTTV-3' protospacer adjacent motif (PAM) next to DNA target sequences restricts Cas12a's gene targeting capability to only ∼1% of a t... | Nucleic Acids Res | Nucleic acids research | 2025 Jul 8 | 2,025 | [
"Ma E",
"Chen K",
"Shi H",
"Wasko KM",
"Esain-Garcia I",
"Trinidad MI",
"Zhou K",
"Ye J",
"Doudna JA"
] | Ma E | Doudna JA | [
"CRISPR-Cas Systems",
"Gene Editing",
"Humans",
"CRISPR-Associated Proteins",
"Directed Molecular Evolution",
"Endodeoxyribonucleases",
"Bacterial Proteins",
"Genome, Human"
] | [
"Journal Article"
] | 53 | 13 | null | pmc-id: PMC12266133; | 0305-1048 | eng | https://pubmed.ncbi.nlm.nih.gov/40671523/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40654677 | 10.1101/2025.05.03.652028 | Improving RNA Secondary Structure Prediction Through Expanded Training Data | In recent years, deep learning has revolutionized protein structure prediction, achieving remarkable speed and accuracy. RNA structure prediction, however, has lagged behind. Although several methods have shown some success in predicting RNA secondary and tertiary structures, none have reached the accuracy observed wit... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Aug 2 | 2,025 | [
"Langeberg CJ",
"Kim T",
"Nagle R",
"Meredith C",
"Garuadapuri DA",
"Doudna JA",
"Cate JHD"
] | Langeberg CJ | Cate JHD | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12247784; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/40654677/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40376084 | 10.1101/2024.10.01.616117 | Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing | RNA-guided CRISPR-Cas enzymes initiate programmable genome editing by recognizing a 20-base-pair DNA sequence adjacent to a short protospacer-adjacent motif (PAM). To uncover the molecular determinants of high-efficiency editing, we conducted biochemical, biophysical and cell-based assays on S. pyogenes Cas9 ( Spy Cas9... | bioRxiv | bioRxiv : the preprint server for biology | 2024 Oct 2 | 2,024 | [
"Shi H",
"Al-Sayyad N",
"Wasko KM",
"Trinidad MI",
"Doherty EE",
"Vohra K",
"Boger RS",
"Colognori D",
"Cofsky JC",
"Skopintsev P",
"Bryant Z",
"Doudna JA"
] | Shi H | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12080945; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/40376084/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40273916 | 10.1016/j.molcel.2025.03.024 | Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing | RNA-guided CRISPR-Cas enzymes initiate programmable genome editing by recognizing a ∼20-base-pair DNA sequence next to a short protospacer-adjacent motif (PAM). To uncover the molecular determinants of high-efficiency editing, we conducted biochemical, biophysical, and cell-based assays on Streptococcus pyogenes Cas9 (... | Mol Cell | Molecular cell | 2025 May 1 | 2,025 | [
"Shi H",
"Al-Sayyad N",
"Wasko KM",
"Trinidad MI",
"Doherty EE",
"Vohra K",
"Boger RS",
"Colognori D",
"Cofsky JC",
"Skopintsev P",
"Bryant Z",
"Doudna JA"
] | Shi H | Doudna JA | [
"CRISPR-Cas Systems",
"Gene Editing",
"RNA, Guide, CRISPR-Cas Systems",
"Streptococcus pyogenes",
"Humans",
"CRISPR-Associated Protein 9",
"HEK293 Cells",
"Bacterial Proteins",
"DNA",
"Nucleotide Motifs"
] | [
"Journal Article"
] | 85 | 9 | 1730-1742.e9 | pmc-id: PMC12258621;manuscript-id: NIHMS2082181; | 1097-2765 | eng | https://pubmed.ncbi.nlm.nih.gov/40273916/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40263581 | 10.1038/s41477-025-01989-9 | Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis | Genome editing is transforming plant biology by enabling precise DNA modifications. However, delivery of editing systems into plants remains challenging, often requiring slow, genotype-specific methods such as tissue culture or transformation1. Plant viruses, which naturally infect and spread to most tissues, present a... | Nat Plants | Nature plants | 2025 May | 2,025 | [
"Weiss T",
"Kamalu M",
"Shi H",
"Li Z",
"Amerasekera J",
"Zhong Z",
"Adler BA",
"Song MM",
"Vohra K",
"Wirnowski G",
"Chitkara S",
"Ambrose C",
"Steinmetz N",
"Sridharan A",
"Sahagun D",
"Banfield JF",
"Doudna JA",
"Jacobsen SE"
] | Weiss T | Jacobsen SE | [
"Arabidopsis",
"Gene Editing",
"Plant Viruses",
"CRISPR-Cas Systems",
"RNA, Guide, CRISPR-Cas Systems",
"Plants, Genetically Modified",
"Transgenes",
"Genome, Plant"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, Non-P.H.S."
] | 11 | 5 | 967-976 | pmc-id: PMC12095077; | 2055-0278 | eng | https://pubmed.ncbi.nlm.nih.gov/40263581/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40196639 | 10.1101/2025.03.26.645588 | Directed evolution expands CRISPR-Cas12a genome editing capacity | CRISPR-Cas12a enzymes are versatile RNA-guided genome-editing tools with applications encompassing viral diagnosis, agriculture and human therapeutics. However, their dependence on a 5'-TTTV-3' protospacer-adjacent motif (PAM) next to DNA target sequences restricts Cas12a's gene targeting capability to only ∼1% of a ty... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Mar 26 | 2,025 | [
"Ma E",
"Chen K",
"Shi H",
"Wasko KM",
"Esain-Garcia I",
"Trinidad MI",
"Zhou K",
"Ye J",
"Doudna JA"
] | Ma E | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC11974813; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/40196639/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40196485 | 10.1101/2025.03.28.646030 | A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway | Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signaling that share mechanistic features with human anti-viral systems 1 . In these pathways, including CBASS and type III CRISPR systems in bacteria and cGAS-STING in humans, oligonucleotide synthesis occurs upon detection of v... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Apr 1 | 2,025 | [
"Doherty EE",
"Adler BA",
"Yoon PH",
"Hsieh K",
"Loi K",
"Armbuster EG",
"Lahiri A",
"Bolling CS",
"Wilcox XE",
"Akkati A",
"Iavarone AT",
"Pogliano J",
"Doudna JA"
] | Doherty EE | Doudna JA | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC11974785; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/40196485/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40168997 | 10.1016/j.chom.2025.03.005 | Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection | Many eukaryotic viruses require membrane-bound compartments for replication, but no such organelles are known to be formed by prokaryotic viruses. Bacteriophages of the Chimalliviridae family sequester their genomes within a phage-generated organelle, the phage nucleus, which is enclosed by a lattice of the viral prote... | Cell Host Microbe | Cell host & microbe | 2025 Apr 9 | 2,025 | [
"Armbruster EG",
"Rani P",
"Lee J",
"Klusch N",
"Hutchings J",
"Hoffman LY",
"Buschkaemper H",
"Enustun E",
"Adler BA",
"Inlow K",
"VanderWal AR",
"Hoffman MY",
"Daksh D",
"Aindow A",
"Deep A",
"Rodriguez ZK",
"Morgan CJ",
"Ghassemian M",
"Laughlin TG",
"Charles E",
"Cress BF... | Armbruster EG | Pogliano J | [
"Genome, Viral",
"Organelles",
"Viral Proteins",
"Bacteriophages",
"Virus Replication",
"Cell Nucleus"
] | [
"Journal Article"
] | 33 | 4 | 484-497.e6 | pmc-id: PMC12256282;manuscript-id: NIHMS2069937; | 1931-3128 | eng | https://pubmed.ncbi.nlm.nih.gov/40168997/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40133266 | 10.1038/s41467-025-57703-y | Dynamic basis of supercoiling-dependent DNA interrogation by Cas12a via R-loop intermediates | The sequence specificity and programmability of DNA binding and cleavage have enabled widespread applications of CRISPR-Cas12a in genetic engineering. As an RNA-guided CRISPR endonuclease, Cas12a engages a 20-base pair (bp) DNA segment by forming a three-stranded R-loop structure in which the guide RNA hybridizes to th... | Nat Commun | Nature communications | 2025 Mar 26 | 2,025 | [
"Aris KDP",
"Cofsky JC",
"Shi H",
"Al-Sayyad N",
"Ivanov IE",
"Balaji A",
"Doudna JA",
"Bryant Z"
] | Aris KDP | Bryant Z | [
"CRISPR-Cas Systems",
"CRISPR-Associated Proteins",
"DNA, Superhelical",
"R-Loop Structures",
"RNA, Guide, CRISPR-Cas Systems",
"Kinetics",
"DNA",
"Endodeoxyribonucleases",
"Bacterial Proteins"
] | [
"Journal Article"
] | 16 | 1 | 2939 | pmc-id: PMC11937380; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/40133266/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40036508 | 10.1093/nar/gkaf105 | Packaged delivery of CRISPR-Cas9 ribonucleoproteins accelerates genome editing | Effective genome editing requires a sufficient dose of CRISPR-Cas9 ribonucleoproteins (RNPs) to enter the target cell while minimizing immune responses, off-target editing, and cytotoxicity. Clinical use of Cas9 RNPs currently entails electroporation into cells ex vivo, but no systematic comparison of this method to pa... | Nucleic Acids Res | Nucleic acids research | 2025 Feb 27 | 2,025 | [
"Karp H",
"Zoltek M",
"Wasko K",
"Vazquez AL",
"Brim J",
"Ngo W",
"Schepartz A",
"Doudna JA"
] | Karp H | Doudna JA | [
"Ribonucleoproteins",
"Gene Editing",
"CRISPR-Cas Systems",
"Humans",
"Electroporation",
"HEK293 Cells",
"CRISPR-Associated Protein 9"
] | [
"Journal Article"
] | 53 | 5 | null | pmc-id: PMC11878570; | 0305-1048 | eng | https://pubmed.ncbi.nlm.nih.gov/40036508/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
40011704 | 10.1038/s41564-025-01935-7 | CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d | Bacteriophages constitute one of the largest reservoirs of genes of unknown function in the biosphere. Even in well-characterized phages, the functions of most genes remain unknown. Experimental approaches to study phage gene fitness and function at genome scale are lacking, partly because phages subvert many modern fu... | Nat Microbiol | Nature microbiology | 2025 Mar | 2,025 | [
"Adler BA",
"Al-Shimary MJ",
"Patel JR",
"Armbruster EG",
"Colognori D",
"Charles EJ",
"Miller KV",
"Lahiri A",
"Cui ML",
"Oromí-Bosch A",
"Voelker A",
"Trinidad M",
"Lee J",
"Beurnier S",
"Boger R",
"Nomburg J",
"Barrangou R",
"Mutalik VK",
"Schoeniger JS",
"Pogliano JA",
"S... | Adler BA | Cress BF | [
"Bacteriophages",
"Genomics",
"CRISPR-Cas Systems",
"Genome, Viral",
"Phylogeny",
"RNA-Binding Proteins",
"Genetic Fitness",
"Bacteriophage lambda"
] | [
"Journal Article"
] | 10 | 3 | 694-709 | pmc-id: PMC11879866; | 2058-5276 | eng | https://pubmed.ncbi.nlm.nih.gov/40011704/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39990302 | 10.1101/2025.02.11.637750 | Mutational scanning of TnpB reveals latent activity for genome editing | TnpB is a diverse family of RNA-guided endonucleases associated with prokaryotic transposons. Due to their small size and putative evolutionary relationship to CRISPR-Cas12, TnpB enzymes hold significant potential for genome editing. However, most TnpBs lack robust gene editing activity, and unbiased profiling of mutat... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Oct 30 | 2,025 | [
"Thornton BW",
"Weissman RF",
"Rodriguez JE",
"Tran RV",
"Duong BT",
"Terrace CI",
"Nagalakshmi U",
"Austin G",
"Groover ED",
"Wang FZ",
"Park JU",
"Georgieva V",
"Tartaglia J",
"Cho MJ",
"Dinesh-Kumar SP",
"Doudna JA",
"Savage DF"
] | Thornton BW | Savage DF | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC11844463; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/39990302/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39966655 | 10.1038/s41587-024-02540-5 | Single-molecule live-cell RNA imaging with CRISPR-Csm | Understanding the diverse dynamic behaviors of individual RNA molecules in single cells requires visualizing them at high resolution in real time. However, single-molecule live-cell imaging of unmodified endogenous RNA has not yet been achieved in a generalizable manner. Here, we present single-molecule live-cell fluor... | Nat Biotechnol | Nature biotechnology | 2025 Dec | 2,025 | [
"Xia C",
"Colognori D",
"Jiang XS",
"Xu K",
"Doudna JA"
] | Xia C | Doudna JA | [
"In Situ Hybridization, Fluorescence",
"Humans",
"Single Molecule Imaging",
"CRISPR-Cas Systems",
"RNA, Messenger",
"RNA",
"Animals",
"Single-Cell Analysis",
"Receptor, Notch2",
"Mice",
"RNA, Guide, CRISPR-Cas Systems",
"Clustered Regularly Interspaced Short Palindromic Repeats"
] | [
"Journal Article"
] | 43 | 12 | 2023-2030 | pmc-id: PMC12700784; | 1087-0156 | eng | https://pubmed.ncbi.nlm.nih.gov/39966655/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39793042 | 10.1073/pnas.2413519121 | Mechanism-guided engineering of a minimal biological particle for genome editing | The widespread application of genome editing to treat and cure disease requires the delivery of genome editors into the nucleus of target cells. Enveloped delivery vehicles (EDVs) are engineered virally derived particles capable of packaging and delivering CRISPR-Cas9 ribonucleoproteins (RNPs). However, the presence of... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2025 Jan 7 | 2,025 | [
"Ngo W",
"Peukes J",
"Baldwin A",
"Xue ZW",
"Hwang S",
"Stickels RR",
"Lin Z",
"Satpathy AT",
"Wells JA",
"Schekman R",
"Nogales E",
"Doudna JA"
] | Ngo W | Doudna JA | [
"Gene Editing",
"Humans",
"CRISPR-Cas Systems",
"Lentivirus",
"Ribonucleoproteins",
"HEK293 Cells",
"CRISPR-Associated Protein 9",
"Genetic Vectors"
] | [
"Journal Article"
] | 122 | 1 | e2413519121 | pmc-id: PMC11725915; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/39793042/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39747192 | 10.1038/s41467-024-55676-y | Functional protein mining with conformal guarantees | Molecular structure prediction and homology detection offer promising paths to discovering protein function and evolutionary relationships. However, current approaches lack statistical reliability assurances, limiting their practical utility for selecting proteins for further experimental and in-silico characterization... | Nat Commun | Nature communications | 2025 Jan 2 | 2,025 | [
"Boger RS",
"Chithrananda S",
"Angelopoulos AN",
"Yoon PH",
"Jordan MI",
"Doudna JA"
] | Boger RS | Doudna JA | [
"Proteins",
"Algorithms",
"Computational Biology",
"Protein Conformation",
"Data Mining",
"Databases, Protein",
"Reproducibility of Results"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 16 | 1 | 85 | pmc-id: PMC11695924; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/39747192/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39698811 | 10.1093/nar/gkae1192 | CRISPR-Cas12a bends DNA to destabilize base pairs during target interrogation | RNA-guided endonucleases are involved in processes ranging from adaptive immunity to site-specific transposition and have revolutionized genome editing. CRISPR-Cas9, -Cas12 and related proteins use guide RNAs to recognize ∼20-nucleotide target sites within genomic DNA by mechanisms that are not yet fully understood. We... | Nucleic Acids Res | Nucleic acids research | 2025 Jan 11 | 2,025 | [
"Soczek KM",
"Cofsky JC",
"Tuck OT",
"Shi H",
"Doudna JA"
] | Soczek KM | Doudna JA | [
"CRISPR-Cas Systems",
"CRISPR-Associated Proteins",
"DNA",
"Base Pairing",
"RNA, Guide, CRISPR-Cas Systems",
"Endodeoxyribonucleases",
"Bacterial Proteins",
"Nucleic Acid Conformation",
"Gene Editing",
"Cryoelectron Microscopy",
"Models, Molecular"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 53 | 2 | null | pmc-id: PMC11754666; | 0305-1048 | eng | https://pubmed.ncbi.nlm.nih.gov/39698811/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39638800 | 10.1038/s41467-024-54812-y | RNA language models predict mutations that improve RNA function | Structured RNA lies at the heart of many central biological processes, from gene expression to catalysis. RNA structure prediction is not yet possible due to a lack of high-quality reference data associated with organismal phenotypes that could inform RNA function. We present GARNET (Gtdb Acquired RNa with Environmenta... | Nat Commun | Nature communications | 2024 Dec 5 | 2,024 | [
"Shulgina Y",
"Trinidad MI",
"Langeberg CJ",
"Nisonoff H",
"Chithrananda S",
"Skopintsev P",
"Nissley AJ",
"Patel J",
"Boger RS",
"Shi H",
"Yoon PH",
"Doherty EE",
"Pande T",
"Iyer AM",
"Doudna JA",
"Cate JHD"
] | Shulgina Y | Cate JHD | [
"Mutation",
"Escherichia coli",
"Nucleic Acid Conformation",
"RNA",
"RNA, Ribosomal",
"Ribosomes",
"Deep Learning"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 15 | 1 | 10627 | pmc-id: PMC11621547; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/39638800/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39571001 | 10.1371/journal.ppat.1012741 | SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation | All lineages of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, contain mutations between amino acids 199 and 205 in the nucleocapsid (N) protein that are associated with increased infectivity. The effects of these mutations have been difficult to determine because N protein contributes to both viral... | PLoS Pathog | PLoS pathogens | 2024 Nov | 2,024 | [
"Syed AM",
"Ciling A",
"Chen IP",
"Carlson CR",
"Adly AN",
"Martin HS",
"Taha TY",
"Khalid MM",
"Price N",
"Bouhaddou M",
"Ummadi MR",
"Moen JM",
"Krogan NJ",
"Morgan DO",
"Ott M",
"Doudna JA"
] | Syed AM | Doudna JA | [
"SARS-CoV-2",
"Phosphorylation",
"Humans",
"Virus Replication",
"Evolution, Molecular",
"COVID-19",
"Coronavirus Nucleocapsid Proteins",
"Phosphoproteins",
"Virus Assembly",
"Mutation",
"Vero Cells",
"Chlorocebus aethiops",
"Animals"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 20 | 11 | e1012741 | pmc-id: PMC11620656; | 1553-7366 | eng | https://pubmed.ncbi.nlm.nih.gov/39571001/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39415058 | 10.1038/s41587-024-02437-3 | Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein | Lipid nanoparticle (LNP) delivery of clustered regularly interspaced short palindromic repeat (CRISPR) ribonucleoproteins (RNPs) could enable high-efficiency, low-toxicity and scalable in vivo genome editing if efficacious RNP-LNP complexes can be reliably produced. Here we engineer a thermostable Cas9 from Geobacillus... | Nat Biotechnol | Nature biotechnology | 2025 Sep | 2,025 | [
"Chen K",
"Han H",
"Zhao S",
"Xu B",
"Yin B",
"Lawanprasert A",
"Trinidad M",
"Burgstone BW",
"Murthy N",
"Doudna JA"
] | Chen K | Doudna JA | [
"Gene Editing",
"Animals",
"CRISPR-Cas Systems",
"Ribonucleoproteins",
"Mice",
"Nanoparticles",
"Liver",
"Lung",
"CRISPR-Associated Protein 9",
"Humans",
"Lipids",
"Liposomes"
] | [
"Journal Article"
] | 43 | 9 | 1445-1457 | pmc-id: PMC12000389;manuscript-id: NIHMS2042429; | 1087-0156 | eng | https://pubmed.ncbi.nlm.nih.gov/39415058/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39395413 | 10.1016/j.cell.2024.09.020 | Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex | Hachiman is a broad-spectrum antiphage defense system of unknown function. We show here that Hachiman is a heterodimeric nuclease-helicase complex, HamAB. HamA, previously a protein of unknown function, is the effector nuclease. HamB is the sensor helicase. HamB constrains HamA activity during surveillance of intact do... | Cell | Cell | 2024 Nov 27 | 2,024 | [
"Tuck OT",
"Adler BA",
"Armbruster EG",
"Lahiri A",
"Hu JJ",
"Zhou J",
"Pogliano J",
"Doudna JA"
] | Tuck OT | Doudna JA | [
"Bacteriophages",
"Cryoelectron Microscopy",
"Deoxyribonucleases",
"Dimerization",
"DNA Damage",
"DNA Helicases",
"Escherichia coli",
"Escherichia coli Proteins"
] | [
"Journal Article"
] | 187 | 24 | 6914-6928.e20 | pmc-id: PMC12278908;manuscript-id: NIHMS2091420; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/39395413/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
39313532 | 10.1038/s41586-024-08068-7 | Author Correction: Birth of protein folds and functions in the virome | null | Nature | Nature | 2024 Oct | 2,024 | [
"Nomburg J",
"Doherty EE",
"Price N",
"Bellieny-Rabelo D",
"Zhu YK",
"Doudna JA"
] | Nomburg J | Doudna JA | [] | [
"Published Erratum"
] | 634 | 8033 | E4 | pmc-id: PMC11464421; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/39313532/ | 9zYNER85lvMln0RUk | Zd9rtnrjTzxwmc0k7 |
42545076 | 10.1002/clc.70434 | Impact of Severe Postoperative Multi-Organ Dysfunction on Long-Term Outcomes After Modified Morrow Surgery | The modified Morrow surgery is the gold standard surgical treatment for hypertrophic obstructive cardiomyopathy (HOCM). While effective, it carries a risk of postoperative severe multi-organ dysfunction and its impact on long-term cardiovascular outcomes remains poorly understood and controversial. This observational c... | Clin Cardiol | Clinical cardiology | 2026 Aug | 2,026 | [
"Wang T",
"Ta L",
"Zhang K",
"Dong R",
"Xiao Y",
"Wang J"
] | Wang T | Wang J | [
"Humans",
"Female",
"Male",
"Cardiomyopathy, Hypertrophic",
"Multiple Organ Failure",
"Postoperative Complications",
"Time Factors",
"Risk Factors",
"Cardiac Surgical Procedures",
"Treatment Outcome",
"Aged",
"Middle Aged",
"Incidence",
"Retrospective Studies",
"Follow-Up Studies",
"Se... | [
"Journal Article",
"Observational Study"
] | 49 | 8 | e70434 | null | 0160-9289 | eng | https://pubmed.ncbi.nlm.nih.gov/42545076/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42544867 | 10.1111/jhn.70324 | ORTO-Measured Orthorexia Nervosa-Related Tendencies Among Dancers Before and During the COVID-19 Pandemic: A Multivariate Analysis | This study aimed to examine the changes in orthorexia nervosa (ON) tendencies among dancers at different levels before and during the COVID-19 pandemic. This retrospective repeated-measures observational study included 128 professional, semi-professional, and amateur dancers (86 females, 42 males; 19-40 years) from var... | J Hum Nutr Diet | Journal of human nutrition and dietetics : the official journal of the British Dietetic Association | 2026 Aug | 2,026 | [
"Ozlu Karahan T",
"Kenger EB",
"Tekin D",
"Agopyan A"
] | Ozlu Karahan T | Agopyan A | [
"Humans",
"Dancing",
"Female",
"COVID-19",
"Retrospective Studies",
"Adult",
"Male",
"Feeding and Eating Disorders",
"Multivariate Analysis",
"Young Adult",
"Feeding Behavior",
"SARS-CoV-2",
"Pandemics",
"Exercise",
"Diet",
"Energy Intake"
] | [
"Journal Article",
"Observational Study"
] | 39 | 4 | e70324 | null | 0952-3871 | eng | https://pubmed.ncbi.nlm.nih.gov/42544867/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42544818 | 10.1111/exd.70337 | LC-OCT for Cutaneous Lupus Erythematosus: Characterization Across Disease Subtypes and Differentiation From Rosacea | Cutaneous lupus erythematosus (CLE) encompasses a heterogeneous group of autoimmune skin manifestations that often overlap clinically with other inflammatory dermatoses, particularly rosacea. While histopathology remains the gold standard, its invasiveness limits routine and longitudinal use. Line-field confocal optica... | Exp Dermatol | Experimental dermatology | 2026 Aug | 2,026 | [
"Traini DO",
"Palmisano G",
"Ventura R",
"Cannizzaro MV",
"De Simone C",
"Rizzuti P",
"Pacucci VA",
"Cerasuolo PG",
"Piunno S",
"Gavotti C",
"Vigilante M",
"Maccari A",
"Caldarola G",
"Ortolan A",
"Suppa M",
"Di Stefani A",
"Agostino MA",
"Peris K"
] | Traini DO | Peris K | [
"Humans",
"Rosacea",
"Tomography, Optical Coherence",
"Lupus Erythematosus, Cutaneous",
"Female",
"Cross-Sectional Studies",
"Male",
"Adult",
"Middle Aged",
"Diagnosis, Differential",
"Skin",
"Aged"
] | [
"Journal Article",
"Observational Study"
] | 35 | 8 | e70337 | null | 0906-6705 | eng | https://pubmed.ncbi.nlm.nih.gov/42544818/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42544642 | 10.1177/17455057261471827 | Microneedling-assisted Panax ginseng exosome protocol for vulvovaginal symptoms and vulvar skin tone changes: A preliminary pilot observational study | BackgroundNonhormonal approaches for vulvovaginal symptoms and vulvar skin concerns are increasingly being explored. However, clinical evidence for combined microneedling-assisted topical protocols in this setting remains limited.ObjectivesThis preliminary pilot observational study explored the short-term feasibility, ... | Womens Health (Lond) | Women's health (London, England) | 2026 Jan-Dec | 2,026 | [
"Park J",
"Kim SG",
"Kim YS",
"Park Y",
"Yi KH"
] | Park J | Yi KH | [
"Humans",
"Female",
"Pilot Projects",
"Middle Aged",
"Adult",
"Panax",
"Percutaneous Collagen Induction",
"Vulva",
"Young Adult",
"Vagina",
"Treatment Outcome",
"Skin Aging"
] | [
"Journal Article",
"Observational Study"
] | 22 | null | 17455057261471827 | null | 1745-5057 | eng | https://pubmed.ncbi.nlm.nih.gov/42544642/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42544613 | 10.1080/07853890.2026.2703403 | Selinexor combined bortezomib, lenalidomide, and dexamethasone for newly diagnosed multiple myeloma with high-risk factors: a single-arm, multi-center, prospective observational clinical study | This study aimed to evaluate the efficacy and safety of selinexor combined with bortezomib, lenalidomide, and dexamethasone (the XVRd regimen) for newly diagnosed multiple myeloma (NDMM) patients with high-risk features. This single-arm, open-label, prospective observational study recruited patients between August 2022... | Ann Med | Annals of medicine | 2026 Dec | 2,026 | [
"Yin J",
"Yu S",
"Wu H",
"Zhou X",
"Li X",
"Yuan C",
"Chu X",
"Wang B",
"Hao L",
"Wei L",
"Zhong Y"
] | Yin J | Zhong Y | [
"Humans",
"Multiple Myeloma",
"Middle Aged",
"Female",
"Dexamethasone",
"Aged",
"Male",
"Prospective Studies",
"Antineoplastic Combined Chemotherapy Protocols",
"Triazoles",
"Lenalidomide",
"Hydrazines",
"Bortezomib",
"Progression-Free Survival",
"Risk Factors",
"Treatment Outcome"
] | [
"Journal Article",
"Observational Study",
"Multicenter Study"
] | 58 | 1 | 2703403 | null | 0785-3890 | eng | https://pubmed.ncbi.nlm.nih.gov/42544613/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42544029 | 10.1002/pri.70281 | Movement Behaviors and Quality of Life in Cardiac Rehabilitation Programs: A Study Based on the Canadian 24-Hour Movement Guidelines | The Canadian 24-Hour Movement Guidelines integrate recommendations on physical activity (PA), sedentary behavior (SB), and sleep. Individuals in cardiac rehabilitation programs (CRPs) have specific characteristics that may influence adherence to these 24-Hour Movement Guidelines and their relationship with quality of l... | Physiother Res Int | Physiotherapy research international : the journal for researchers and clinicians in physical therapy | 2026 Oct | 2,026 | [
"Soares JCÁ",
"Vigilato MEM",
"Valente HB",
"Moliterno AH",
"Silva JPLN",
"Christofaro DGD",
"Vanderlei LCM"
] | Soares JCÁ | Vanderlei LCM | [
"Humans",
"Quality of Life",
"Cross-Sectional Studies",
"Female",
"Male",
"Aged",
"Cardiac Rehabilitation",
"Canada",
"Sedentary Behavior",
"Middle Aged",
"Sleep Duration",
"Sleep",
"Guideline Adherence",
"Exercise",
"Practice Guidelines as Topic"
] | [
"Journal Article",
"Observational Study"
] | 31 | 4 | e70281 | null | 1358-2267 | eng | https://pubmed.ncbi.nlm.nih.gov/42544029/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42544023 | 10.3238/arztebl.m2026.0134 | Post-Infectious Syndromes in the Post-Pandemic Phase Among the German General Population | Persistent symptoms after a respiratory infection can impair daily life, as has been shown, for example, for "long COVID." In this study, we determined the frequency and impact of symptoms that persisted for 12 weeks or more after a respiratory infection. A further endpoint was health care utilization for such symptoms... | Dtsch Arztebl Int | Deutsches Arzteblatt international | 2026 Sep 18 | 2,026 | [
"Mikolajczyk R"
] | Mikolajczyk R | Mikolajczyk R | [] | [
"Journal Article",
"Observational Study"
] | 123 | 19 | null | null | 1866-0452 | eng | https://pubmed.ncbi.nlm.nih.gov/42544023/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543992 | 10.59556/japi.74.1616 | Clinicopathological Features and Outcomes of Metastatic Colorectal Cancers Treated at a Tertiary Care Hospital: A Bidirectional Observational Study | Metastatic colorectal cancer (mCRC) remains a major contributor to cancer-related mortality worldwide. Real-world data from low- and middle-income countries remain limited. This bidirectional observational study included 60 patients with histologically confirmed mCRC treated at a tertiary care center between January 20... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jul | 2,026 | [
"Natti HS",
"Gumdal V",
"Koppaka D",
"Nuguri S",
"Potu SR",
"Rudra RS",
"Jaffer RM"
] | Natti HS | Jaffer RM | [
"Humans",
"Male",
"Colorectal Neoplasms",
"Middle Aged",
"Tertiary Care Centers",
"Female",
"Adult",
"Aged",
"India",
"Prognosis",
"Microsatellite Instability",
"Proto-Oncogene Proteins p21(ras)",
"Neoplasm Metastasis",
"Progression-Free Survival"
] | [
"Journal Article",
"Observational Study"
] | 74 | 7 | 49-54 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543992/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543989 | 10.59556/japi.74.1609 | Cardiac Magnetic Resonance Imaging Study on Cardiovascular Involvement >60 Days Post COVID-19 Recovery | This study evaluates individuals who have recovered from coronavirus disease 2019 (COVID-19) for cardiac manifestations at least 60 days postrecovery, using cardiac magnetic resonance (CMR) imaging. Native T1, native T2, and late gadolinium enhancement (LGE) were used as parameters to detect potential cardiac pathologi... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jul | 2,026 | [
"Mehta N",
"Banerjee TS",
"Karnavat CO",
"Parikh RM",
"Kashikar R",
"Sinhasan S",
"Tandan-Pardasani S",
"Bindroo S",
"Bhabhor A",
"Raut I",
"Shah N",
"Desai SB",
"Kapadia M",
"Desai M",
"Kapoor A"
] | Mehta N | Kapoor A | [
"Humans",
"Female",
"COVID-19",
"Male",
"Prospective Studies",
"Magnetic Resonance Imaging",
"Adult",
"Middle Aged",
"Post-Acute COVID-19 Syndrome",
"India",
"Cardiovascular Diseases",
"SARS-CoV-2",
"Heart Diseases",
"Time Factors"
] | [
"Journal Article",
"Observational Study"
] | 74 | 7 | 32-37 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543989/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543986 | 10.59556/japi.74.1593 | A Cross-sectional Study to Assess the Knowledge, Attitude, and Practice of Look-alike, Sound-alike Drugs among Healthcare Providers at a Tertiary Care Hospital | Sometimes, drug names or their appearances create confusion among healthcare providers. These look-alike or sound-alike (LASA) drugs have the potential to cause medication errors leading to patient harm. Such errors can occur during prescribing, dispensing, and administration of drugs. Therefore, this study was conduct... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jul | 2,026 | [
"Bansal N",
"Khobragade AAK",
"Bawne AR",
"Bavlecha A",
"Kohli BS"
] | Bansal N | Kohli BS | [
"Humans",
"Cross-Sectional Studies",
"Tertiary Care Centers",
"Health Knowledge, Attitudes, Practice",
"India",
"Male",
"Medication Errors",
"Female",
"Adult",
"Surveys and Questionnaires",
"Health Personnel",
"Attitude of Health Personnel",
"Middle Aged"
] | [
"Journal Article",
"Observational Study"
] | 74 | 7 | 20-23 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543986/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543985 | 10.59556/japi.74.1571 | Spectrum and Clinical Burden of Drug-induced Ataxia in Low-resource Settings: An Observational Study | The clinical manifestation of drug-induced ataxia (DIA) is well established clinically but often becomes unrecognized until actual ataxia occurs. DIA may include ataxia as its primary clinical symptom or may be one of multiple manifestations. This study aimed to characterize the development of DIA types and the timing ... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jul | 2,026 | [
"Saibaba J",
"Subramaniam MP",
"Thangavelu AP",
"Rennukaranjan KC"
] | Saibaba J | Rennukaranjan KC | [
"Humans",
"Ataxia",
"Female",
"Male",
"Prospective Studies",
"Anticonvulsants",
"Adult",
"Middle Aged",
"Resource-Limited Settings",
"India"
] | [
"Journal Article",
"Observational Study"
] | 74 | 7 | 15-19 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543985/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543984 | 10.59556/japi.74.1614 | Incidence of Infections in Renal Allograft Recipients and Their Outcomes in a Tertiary Care Center in Northeast India | The advent of modern potent immunosuppression has significantly reduced the occurrence of rejection in renal allograft recipients but has increased the risk of infection, which remains the major cause of death in these patients. This single-center retrospective observational study was conducted at a tertiary care cente... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jul | 2,026 | [
"Hajong S",
"Sharma M",
"Hakmaosa A",
"Doley PK",
"Pegu G"
] | Hajong S | Pegu G | [
"Humans",
"Kidney Transplantation",
"India",
"Male",
"Tertiary Care Centers",
"Female",
"Retrospective Studies",
"Incidence",
"Adult",
"Urinary Tract Infections",
"Middle Aged",
"Pneumonia",
"Postoperative Complications"
] | [
"Journal Article",
"Observational Study"
] | 74 | 7 | 13-14 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543984/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543957 | 10.59556/japi.74.1607 | Clinical Characteristics Treatment Approaches and Survival Outcomes in Secondary Hemophagocytic Lymphohistiocytosis: A Retrospective Observational Study | Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal syndrome characterized by immune hyperactivation and a cytokine storm, leading to fever, cytopenia, organomegaly, and multiorgan dysfunction. Given its high morbidity and mortality, prompt diagnosis and treatment are essential. Currently, there ar... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jul | 2,026 | [
"Varshney A",
"Phadke PS",
"Prabhakaran A",
"Patade D",
"Bhalani Y",
"Kumar A"
] | Varshney A | Kumar A | [
"Humans",
"Lymphohistiocytosis, Hemophagocytic",
"Female",
"Retrospective Studies",
"Male",
"Dexamethasone",
"Prognosis",
"Etoposide",
"Ferritins",
"Treatment Outcome",
"Adolescent",
"Child",
"Glucocorticoids",
"Child, Preschool",
"Adult",
"Neutrophils",
"Leukocyte Count",
"Remissi... | [
"Journal Article",
"Observational Study"
] | 74 | 7E | e18-e24 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543957/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543955 | 10.59556/japi.74.1560 | Barriers to Timely Rheumatologic Care for Rheumatoid Arthritis: A Real-World Questionnaire-based Study from Karnataka Chapter of Indian Rheumatology Association (KRA) | To assess referral timelines to rheumatologists in Karnataka, India, identify factors linked to delays, and to examine their impact on disease activity, functional disability, and economic burden. A multicenter, cross-sectional, observational questionnaire-based study was conducted across 17 rheumatology centers in Kar... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jul | 2,026 | [
"Shobha V",
"Subramanian R",
"Prakruthi J",
"Selvam S",
"Shaleni V",
"Haridas V",
"Mamadapur M",
"Kamath A",
"Arjun MN",
"Chebbi P",
"Vahaneyil JM",
"Vr SV",
"Patil A",
"Pinto B",
"Yathish GC",
"Jeevanagi SR",
"Baliga S",
"Harshini AS",
"Singhai S",
"Rao VK",
"Ramachandran V"... | Shobha V | Mahendranath KM | [
"Humans",
"Arthritis, Rheumatoid",
"India",
"Female",
"Cross-Sectional Studies",
"Referral and Consultation",
"Male",
"Middle Aged",
"Treatment Delay",
"Surveys and Questionnaires",
"Rheumatology",
"Adult",
"Health Expenditures",
"Health Services Accessibility",
"Time-to-Treatment",
"A... | [
"Journal Article",
"Observational Study",
"Multicenter Study"
] | 74 | 7E | e1-e8 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543955/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543952 | 10.59556/japi.74.1544 | Reliability of Arterial Blood Gas Analyzer for Electrolyte and Hemoglobin Measurement: A Method Comparison Study | Rapid assessment of electrolytes and hemoglobin is crucial in emergency and critical care. Arterial blood gas (ABG) analyzers are widely used as point-of-care devices. However, their agreement with central laboratory measurements remains uncertain because of methodological differences. This study aimed to evaluate the ... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Dhanapalan A",
"Murugiah V",
"Ramasamy J",
"Raja NK"
] | Dhanapalan A | Raja NK | [
"Humans",
"Blood Gas Analysis",
"Reproducibility of Results",
"Hemoglobins",
"Prospective Studies",
"Electrolytes",
"Potassium",
"Chlorides",
"Point-of-Care Systems",
"Sodium"
] | [
"Journal Article",
"Comparative Study",
"Observational Study"
] | 74 | 6E | e35-e38 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543952/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543946 | 10.59556/japi.74.1512 | A Study of the Clinicoetiological Profile of Hyponatremia in Patients in a Tertiary Care Hospital | Hyponatremia is a common and important electrolyte imbalance seen both in isolation and more commonly, as a complication of other medical illnesses. With a wide spectrum of presentations, the prognostic implications are grave and far-reaching if not addressed meticulously. Despite the knowledge of hyponatremia since th... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Somendra S",
"Sharma R"
] | Somendra S | Sharma R | [
"Humans",
"Hyponatremia",
"Inappropriate ADH Syndrome",
"Tertiary Care Centers",
"Male",
"Female",
"India",
"Middle Aged",
"Adult",
"Sodium",
"Sepsis"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6E | e6-e8 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543946/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543936 | 10.59556/japi.74.1508 | Semaglutide in Practice: Insights from a Retrospective Case Series at a Jharkhand Tertiary Care Hospital | Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has demonstrated efficacy in improving glycemic control and reducing cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). However, real-world evidence from Indian populations remains limited. This study aimed to assess the effectiveness a... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Jha AK",
"Sunder A"
] | Jha AK | Sunder A | [
"Humans",
"Semaglutide",
"Female",
"Male",
"Diabetes Mellitus, Type 2",
"Retrospective Studies",
"Glucagon-Like Peptides",
"Hypoglycemic Agents",
"India",
"Glycated Hemoglobin",
"Tertiary Care Centers",
"Middle Aged",
"Blood Glucose",
"Body Weight",
"Aged",
"Treatment Outcome"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 74-77 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543936/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543934 | 10.59556/japi.74.1548 | Imeglimin in Indian Adults with Type 2 Diabetes: A Prospective Multicenter Real-world Cohort Study of Prescription Patterns, Glycemic Change, and Safety | Imeglimin is a novel oral glucose-lowering agent targeting mitochondrial dysfunction. While randomized trials demonstrate its efficacy, real-world data in diverse populations remain limited. We evaluated the effectiveness, safety, and utilization patterns of imeglimin in Indian adults with inadequately controlled type ... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Saboo B",
"Samajdar SS",
"Maheshwari A",
"Saboo B",
"Panda JK",
"Inamdar AV",
"Agarwal P",
"Ghosh S",
"Patil S",
"Saxena D",
"Gokalani R",
"Kiran G",
"Singh NK",
"Pamnani H",
"Chakravarti HN",
"Agrawala RK",
"Singh V",
"Ahmed R",
"Tamhankar G",
"Joshi S"
] | Saboo B | Joshi S | [
"Humans",
"Diabetes Mellitus, Type 2",
"Middle Aged",
"Female",
"Male",
"India",
"Prospective Studies",
"Hypoglycemic Agents",
"Glycated Hemoglobin",
"Adult",
"Blood Glucose",
"Treatment Outcome",
"Practice Patterns, Physicians'",
"Aged",
"Hypoglycemia",
"Triazines"
] | [
"Journal Article",
"Multicenter Study",
"Observational Study"
] | 74 | 6 | 56-65 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543934/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543931 | 10.59556/japi.74.1538 | A Study of the Clinical Profile of Acute Poisoning in Adults in a Rural Tertiary Healthcare Setup | Acute poisoning remains a major public health concern in rural India due to easy accessibility of toxic substances and limited mental health support. This retrospective observational study was conducted at a tertiary care teaching hospital in rural Bengaluru to evaluate the clinical and epidemiological profile of poiso... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Murthy MS",
"Kumar PG",
"Suhas SV"
] | Murthy MS | Suhas SV | [
"Humans",
"Female",
"Adult",
"Male",
"India",
"Retrospective Studies",
"Poisoning",
"Young Adult",
"Middle Aged",
"Adolescent",
"Rural Population",
"Acute Disease",
"Suicide, Attempted",
"Organophosphate Poisoning",
"Tertiary Care Centers"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 41-45 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543931/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543930 | 10.59556/japi.74.1520 | Prevalence of Celiac Disease in Inflammatory Bowel Disease: A Prospective Cohort Study from Northern India | Celiac disease (CeD) and inflammatory bowel disease (IBD) share immune and genetic pathophysiological pathways, suggesting a possible increased coexistence. Indian data on biopsy-confirmed CeD in IBD are limited, and false-positive anti-tissue transglutaminase (tTG) antibody results complicate interpretation. To determ... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Kumar M",
"Sapra B",
"Sharma PN",
"Maharshi S",
"Sharma SS"
] | Kumar M | Sharma SS | [
"Humans",
"Celiac Disease",
"India",
"Female",
"Prevalence",
"Prospective Studies",
"Male",
"Adult",
"Inflammatory Bowel Diseases",
"Middle Aged",
"Biopsy",
"Transglutaminases",
"Adolescent",
"Young Adult"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 36-40 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543930/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543929 | 10.59556/japi.74.1525 | Effect of Radiological Patterns on Response to Pulmonary Rehabilitation in Post-tuberculosis Lung Sequelae: A Prospective Observational Study | Post-tuberculosis sequelae (PTBS) are increasingly recognized as a significant cause of long-term respiratory morbidity, manifesting with dyspnea, reduced pulmonary function, impaired exercise capacity, and diminished quality of life. Despite their burden, PTBS patients often lack access to structured rehabilitation. P... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Mehta M",
"Dixit R"
] | Mehta M | Dixit R | [
"Humans",
"Male",
"Prospective Studies",
"Female",
"Tuberculosis, Pulmonary",
"Middle Aged",
"Quality of Life",
"Adult",
"India",
"Respiratory Function Tests",
"Bronchiectasis",
"Lung",
"Treatment Outcome",
"Pulmonary Fibrosis"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 29-34 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543929/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543928 | 10.59556/japi.74.1526 | AI-powered ECG Interpretation System for Arrhythmia Prediction and Hyperkalemia Detection Using Machine Learning | Artificial intelligence (AI) has emerged as a powerful tool for electrocardiogram (ECG) analysis, potentially surpassing conventional interpretation in detecting arrhythmias and metabolic disturbances such as hyperkalemia. This study evaluated the diagnostic performance and real-world applicability of an AI-powered ECG... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Kumar A",
"Bansal T",
"Jaura S"
] | Kumar A | Jaura S | [
"Humans",
"Hyperkalemia",
"Electrocardiography",
"Female",
"Arrhythmias, Cardiac",
"Machine Learning",
"Prospective Studies",
"Artificial Intelligence",
"Male",
"Middle Aged",
"Sensitivity and Specificity",
"Predictive Value of Tests",
"Aged"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 25-28 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543928/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543927 | 10.59556/japi.74.1515 | From Recognition to Reporting: One-year Trends in Adverse Drug Reactions at a Newly Designated Adverse Drug Reaction Monitoring Center | To analyze spontaneously reported adverse drug reactions (ADRs) during the first year after the adverse drug reaction monitoring center (AMC) recognition. A retrospective observational study was conducted from April 2023 to March 2024 at a tertiary care hospital in Pune, Maharashtra, India. All reported ADRs were inclu... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Londhe VA",
"Dhande PP"
] | Londhe VA | Dhande PP | [
"Humans",
"Adverse Drug Reaction Reporting Systems",
"Drug-Related Side Effects and Adverse Reactions",
"Retrospective Studies",
"Female",
"Aged",
"Middle Aged",
"India",
"Male",
"Aged, 80 and over",
"Adult",
"Pharmacovigilance"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 22-24 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543927/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543926 | 10.59556/japi.74.1516 | Role of Expanded A-DROP Score in Predicting 14-day Mortality in Patients with Community-acquired Pneumonia: A Prospective Observational Study from a Tertiary Care Center in North India | Community-acquired pneumonia (CAP) carries substantial mortality. Common scoring tools such as CURB-65, A-DROP, and PSI have limitations. The expanded A-DROP incorporates clinical and biochemical markers, showing promise and requires validation in Indian settings. This prospective observational study at a North Indian ... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Prakash R",
"Sinha N",
"Goyal P"
] | Prakash R | Goyal P | [
"Humans",
"Community-Acquired Pneumonia",
"India",
"Prospective Studies",
"Tertiary Care Centers",
"Female",
"Male",
"Middle Aged",
"Severity of Illness Index",
"Aged",
"ROC Curve",
"Hospital Mortality",
"Adult",
"Intensive Care Units",
"Community-Acquired Infections"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 16-21 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543926/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543925 | 10.59556/japi.74.1502 | Hypothyroidism in Nonalcoholic Fatty Liver Disease | Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with increasing global prevalence. Thyroid dysfunction, particularly hypothyroidism, has been implicated in its pathogenesis and progression. To evaluate the prevalence and pattern of hypothyroidism in NAFLD patients and assess its ass... | J Assoc Physicians India | The Journal of the Association of Physicians of India | 2026 Jun | 2,026 | [
"Chaudhary SC",
"Singh P",
"Usman K",
"Sawlani KK",
"Gupta KK",
"Kumar V",
"Patel ML",
"Gupta AK",
"Rungta S",
"Parihar A"
] | Chaudhary SC | Parihar A | [
"Humans",
"Non-alcoholic Fatty Liver Disease",
"Hypothyroidism",
"Male",
"Cross-Sectional Studies",
"Female",
"Adult",
"Middle Aged",
"Prevalence",
"Severity of Illness Index",
"India",
"Liver Cirrhosis",
"Elasticity Imaging Techniques",
"Ultrasonography",
"Disease Progression"
] | [
"Journal Article",
"Observational Study"
] | 74 | 6 | 12-15 | null | 0004-5772 | eng | https://pubmed.ncbi.nlm.nih.gov/42543925/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543749 | 10.1111/jog.70432 | Antenatal Prediction Model for Neonatal Intensive Care Unit Admission in Late Preterm Infants | To develop and internally validate an antenatal prediction model for neonatal intensive care unit (NICU) admission among late preterm infants using routinely available maternal and obstetric parameters. This retrospective observational cohort study included deliveries between 340/7 and 366/7 weeks of gestation at a ter... | J Obstet Gynaecol Res | The journal of obstetrics and gynaecology research | 2026 Aug | 2,026 | [
"Yergin E",
"Taşkum İ",
"Sucu S",
"Yetişkin FDY",
"Özkan S",
"Makansi N",
"Barutçu C",
"Sınacı S"
] | Yergin E | Sınacı S | [
"Humans",
"Female",
"Intensive Care Units, Neonatal",
"Pregnancy",
"Retrospective Studies",
"Infant, Newborn",
"Infant, Premature",
"Nomograms",
"Adult",
"Patient Admission",
"Gestational Age",
"Prediction Algorithms"
] | [
"Journal Article",
"Observational Study"
] | 52 | 8 | e70432 | null | 1341-8076 | eng | https://pubmed.ncbi.nlm.nih.gov/42543749/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42543664 | 10.1536/ihj.26-140 | Age-Related Impairment of Left Atrial Phasic Strain in Childhood Cancer Survivors Treated with Anthracyclines | Childhood cancer survivors (CCSs) are at increased risk of cancer therapy-related cardiac dysfunction following anthracycline chemotherapy. Although left atrial (LA) strain assessed by speckle-tracking echocardiography has emerged as a sensitive marker of diastolic dysfunction, it remains unclear when during survivorsh... | Int Heart J | International heart journal | 2026 | 2,026 | [
"Sato H",
"Takahashi K",
"Hosono Y",
"Shigemitsu S",
"Akatsuka Y",
"Sato K",
"Kago H",
"Akiya A",
"Akimoto S",
"Ifuku M",
"Yazaki K",
"Wakatsuki H",
"Yaguchi A",
"Tomita O",
"Fujimura J",
"Saito M",
"Shimizu T"
] | Sato H | Shimizu T | [
"Humans",
"Anthracyclines",
"Retrospective Studies",
"Adolescent",
"Adult",
"Child",
"Young Adult",
"Cancer Survivors",
"Heart Atria",
"Female",
"Case-Control Studies",
"Male",
"Child, Preschool",
"Atrial Function, Left",
"Age Factors",
"Echocardiography, Doppler",
"Echocardiography"... | [
"Journal Article",
"Observational Study"
] | 67 | 4 | 333-341 | null | 1349-2365 | eng | https://pubmed.ncbi.nlm.nih.gov/42543664/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542921 | 10.52312/jdrs.2026.2776 | Early gait recovery following medial open-wedge high tibial osteotomy: A prospective gait analysis study | This study aims to evaluate the effects of medial openwedge high tibial osteotomy (OWHTO) on gait analysis outcomes in patients with medial compartment osteoarthritis and varus alignment of the knee. This prospective, observational study included a total of 22 patients who underwent biplanar medial OWHTO between Februa... | Jt Dis Relat Surg | Joint diseases and related surgery | 2026 Jul 23 | 2,026 | [
"Emir MM",
"Uysal ÖS",
"Javadov G",
"Yılmaz S",
"Hajouj J",
"Öktem U",
"Adıgüzel E",
"Tecimel O",
"Öçgüder DA"
] | Emir MM | Öçgüder DA | [
"Humans",
"Osteotomy",
"Female",
"Prospective Studies",
"Male",
"Middle Aged",
"Tibia",
"Osteoarthritis, Knee",
"Gait Analysis",
"Recovery of Function",
"Gait",
"Biomechanical Phenomena",
"Treatment Outcome",
"Knee Joint"
] | [
"Journal Article",
"Observational Study"
] | 37 | 3 | 768-776 | null | 2687-4792 | eng | https://pubmed.ncbi.nlm.nih.gov/42542921/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542879 | 10.7717/peerj.21545 | Perceptions about protein supplements among adults in Saudi Arabia (knowledge and attitude, use, health beliefs, and safety concerns) | Protein supplements have gained popularity among gym users in Saudi Arabia. This study aimed to collect data from adults in Saudi Arabia focusing on six components related to protein supplements: demographic characteristics of participants, health and physical activity information, knowledge and attitudes, use, health ... | PeerJ | PeerJ | 2026 | 2,026 | [
"Alaoufi S",
"Alhomaid RM"
] | Alaoufi S | Alhomaid RM | [
"Humans",
"Male",
"Saudi Arabia",
"Female",
"Health Knowledge, Attitudes, Practice",
"Dietary Supplements",
"Adult",
"Cross-Sectional Studies",
"Young Adult",
"Dietary Proteins",
"Surveys and Questionnaires",
"Middle Aged",
"Adolescent"
] | [
"Journal Article",
"Observational Study"
] | 14 | null | e21545 | pmc-id: PMC13428538; | 2167-8359 | eng | https://pubmed.ncbi.nlm.nih.gov/42542879/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542564 | 10.12659/MSM.953081 | Ultrasound-Guided Pericapsular Nerve Group Block vs Suprainguinal Fascia Iliaca Block for Analgesia in Hip Fracture Surgery: A Prospective Comparative Observational Study | BACKGROUND Hip fractures cause severe perioperative pain, increased opioid use, and delayed recovery. The ultrasound-guided pericapsular nerve group (PENG) and suprainguinal fascia iliaca (SIFI) blocks are regional techniques targeting hip innervation. This study aimed to compare the effects of ultrasound-guided PENG a... | Med Sci Monit | Medical science monitor : international medical journal of experimental and clinical research | 2026 Aug 2 | 2,026 | [
"Dedeoğlu A",
"Acil F",
"Andıç O",
"Uzundere O",
"Gökçek E",
"Kaçar CK"
] | Dedeoğlu A | Kaçar CK | [
"Humans",
"Female",
"Nerve Block",
"Male",
"Prospective Studies",
"Hip Fractures",
"Postoperative Pain",
"Analgesia",
"Aged",
"Ultrasonography, Interventional",
"Aged, 80 and over",
"Pain Measurement",
"Pain Management",
"Fascia",
"Treatment Outcome"
] | [
"Journal Article",
"Observational Study",
"Comparative Study"
] | 32 | null | e953081 | null | 1234-1010 | eng | https://pubmed.ncbi.nlm.nih.gov/42542564/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542551 | 10.1186/s12903-026-09440-x | Validity and reliability of the smile perception scale in Turkish children aged 8-10 years | Dental aesthetics plays a key role in children's social perception and psychosocial development. However, evidence on smile perception in children remains limited, highlighting the need for valid and reliable assessment tools. This study aimed to perform the cross-cultural adaptation and psychometric validation of the ... | BMC Oral Health | BMC oral health | 2026 Jul 29 | 2,026 | [
"Özgöçmen Tula E",
"Ayvallı Karagöz M",
"Alkış M"
] | Özgöçmen Tula E | Alkış M | [
"Humans",
"Child",
"Smiling",
"Turkey",
"Reproducibility of Results",
"Female",
"Male",
"Psychometrics",
"Surveys and Questionnaires",
"Esthetics, Dental"
] | [
"Journal Article",
"Validation Study",
"Observational Study"
] | 26 | 1 | null | pmc-id: PMC13429015; | 1472-6831 | eng | https://pubmed.ncbi.nlm.nih.gov/42542551/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542442 | 10.1007/s00431-026-07286-7 | Autopsy in sudden unexplained death in youth: indispensable or in some cases redundant? An observational study | Sudden Unexplained Death in Youth (SUDY) requires thorough investigation to identify underlying causes and guide prevention strategies. In the Netherlands, cases are investigated using the standardized Postmortem Evaluation of Sudden Unexplained Death in Infants and Children (PESUDIC), in which autopsy is offered as a ... | Eur J Pediatr | European journal of pediatrics | 2026 Aug 1 | 2,026 | [
"van der Gugten AC",
"Wemeijer TM",
"Semmekrot BA",
"Smit RBJ",
"Oostdam C",
"Duijst WLJM",
"de Gier S",
"van de Putte E",
"PESUDIC collaborative"
] | van der Gugten AC | van de Putte E | [
"Humans",
"Child",
"Male",
"Death, Sudden",
"Autopsy",
"Child, Preschool",
"Adolescent",
"Cause of Death",
"Female",
"Netherlands"
] | [
"Journal Article",
"Observational Study"
] | 185 | 8 | null | pmc-id: PMC13428766; | 0340-6199 | eng | https://pubmed.ncbi.nlm.nih.gov/42542442/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542436 | 10.1007/s00431-026-07295-6 | Health complaints, social impacts, and perceived care effectiveness reported by children with obesity and their parents: a prospective observational study in the Obesity Center CGG cohort | Obesity is a chronic relapsing disease leading to weight-related health risks for disorders such as cardiovascular diseases, type 2 diabetes, osteoarthritis, and depression. Many studies focus on these weight-related health risks. However, research on current self-reported social impacts and health complaints is limite... | Eur J Pediatr | European journal of pediatrics | 2026 Aug 1 | 2,026 | [
"van der Velden MMAM",
"van der Walle EEPL",
"Bindels PPJE",
"van Middelkoop M",
"van den Akker EELT"
] | van der Velden MMAM | van den Akker EELT | [
"Humans",
"Female",
"Child",
"Male",
"Prospective Studies",
"Adolescent",
"Parents",
"Pediatric Obesity",
"Child, Preschool",
"Quality of Life",
"Infant",
"Surveys and Questionnaires",
"Self Report"
] | [
"Journal Article",
"Observational Study"
] | 185 | 8 | null | pmc-id: PMC13428758; | 0340-6199 | eng | https://pubmed.ncbi.nlm.nih.gov/42542436/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542349 | 10.1016/j.eimce.2026.503107 | Five years-real-world experience with FilmArray Pneumonia Plus Panel in the diagnosis of pneumonia in an intensive care unit in a tertiary hospital: Lights and shadows in pandemic and postpandemic COVID periods | The main objective of the study is to evaluate the performance of the FilmArray® Pneumonia Plus (FA-PP) panel in critically ill patients with suspected pneumonia compared to conventional culture, in both pandemic and pospandemic periods, and its impact on therapeutic decision-making. Observational study including 225 p... | Enferm Infecc Microbiol Clin (Engl Ed) | Enfermedades infecciosas y microbiologia clinica (English ed.) | 2026 Aug-Sep | 2,026 | [
"García-Lechuz JM",
"Arias A",
"Alonso P",
"Badenas-Alzugaray D",
"Viñeta V",
"Claraco L",
"Gurpegui M",
"Carrillo A",
"Viñuelas J"
] | García-Lechuz JM | Viñuelas J | [
"Humans",
"Intensive Care Units",
"COVID-19",
"Tertiary Care Centers",
"Female",
"Middle Aged",
"Male",
"Aged",
"Sensitivity and Specificity",
"Time Factors",
"Pandemics",
"Anti-Bacterial Agents",
"Predictive Value of Tests",
"SARS-CoV-2",
"Pneumonia",
"Pneumonia, Bacterial"
] | [
"Journal Article",
"Observational Study",
"Comparative Study"
] | 44 | 7 | 503107 | null | 2529-993X | eng | https://pubmed.ncbi.nlm.nih.gov/42542349/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42542322 | 10.3357/AMHP.6887.2026 | Psychomotor Alertness and Subjective Fatigue in Helicopter Pilots | Fatigue poses a significant safety risk in helicopter operations; however, subjective assessments of fatigue based on an individual's perception, awareness, and insight, such as self-perceived tiredness, may not accurately reflect objective performance impairment as identified by standardized tests or measurement tools... | Aerosp Med Hum Perform | Aerospace medicine and human performance | 2026 Aug | 2,026 | [
"Gevrek I",
"Eroglu C"
] | Gevrek I | Eroglu C | [
"Humans",
"Fatigue",
"Psychomotor Performance",
"Adult",
"Reaction Time",
"Male",
"Pilots",
"Aircraft",
"Sleepiness",
"Middle Aged",
"Aerospace Medicine",
"Attention",
"Wakefulness",
"Female"
] | [
"Journal Article",
"Observational Study"
] | 97 | 8 | 633-637 | null | 2375-6314 | eng | https://pubmed.ncbi.nlm.nih.gov/42542322/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42541791 | null | [Rabies post-exposure prophylaxis in travelers returning from endemic areas: A retrospective analysis of patients treated at Motol and Homolka University Hospital] | To characterize the demographic and exposure characteristics and management of rabies post-exposure prophylaxis (rPEP) among international travelers, and to identify deficiencies in pre-travel prevention, initial wound management, and subsequent post-exposure care. A retrospective observational study was conducted at t... | Klin Mikrobiol Infekc Lek | Klinicka mikrobiologie a infekcni lekarstvi | 2026 Jun | 2,026 | [
"Trojánek M",
"Šindlerová R",
"Jegorova V",
"Tulach M",
"Martišík S",
"Štefan M",
"Grebenyuk V",
"Stejskal F"
] | Trojánek M | Stejskal F | [
"Humans",
"Rabies",
"Retrospective Studies",
"Post-Exposure Prophylaxis",
"Female",
"Adult",
"Male",
"Animals",
"Rabies Vaccines",
"Travel",
"Middle Aged",
"Adolescent",
"Young Adult",
"Cats",
"Child",
"Hospitals, University",
"Dogs",
"Bites and Stings"
] | [
"Journal Article",
"Observational Study",
"English Abstract"
] | 32 | 2 | 56-64 | null | 1211-264X | cze | https://pubmed.ncbi.nlm.nih.gov/42541791/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42541783 | 10.5137/1019-5149.JTN.49051-25.4 | Determination of Optic Nerve Sheath Diameter Cut-off after CSF Drainage in Adults with Elevated ICP: A Prospective Study | AIM: To evaluate the relationship between optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) in patients with acute ICP elevation controlled through external ventricular drainage (EVD). MATERIAL and METHODS: In this prospective observational study, simultaneous measurements of right and left ONSD, ICP, ... | Turk Neurosurg | Turkish neurosurgery | 2026 | 2,026 | [
"Ozkaya G",
"Korkmaz Dilmen O",
"Akcil EF",
"Tunali Y"
] | Ozkaya G | Tunali Y | [
"Humans",
"Optic Nerve",
"Female",
"Prospective Studies",
"Adult",
"Male",
"Middle Aged",
"Intracranial Pressure",
"Intracranial Hypertension",
"Drainage",
"Aged"
] | [
"Journal Article",
"Observational Study"
] | 36 | 4 | 573-580 | null | 1019-5149 | eng | https://pubmed.ncbi.nlm.nih.gov/42541783/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42541750 | 10.1002/jfa2.70183 | Intrinsic Foot Muscle Cross-Sectional Area on MRI in People With and Without Plantar Heel Pain: A Cross-Sectional Observational Study | This study compared the cross-sectional areas (CSA) of key intrinsic foot muscles in people with and without plantar heel pain (PHP). Seventy-five adults participated in the study: 50 participants with PHP and 25 age-, sex-, and body mass index (BMI)-matched participants without PHP (control group). Cross-sectional ima... | J Foot Ankle Res | Journal of foot and ankle research | 2026 Sep | 2,026 | [
"Osborne JWA",
"Azevedo AM",
"Menz HB",
"Whittaker GA",
"Cotchett M",
"Entwisle T",
"Connell DA",
"Munteanu SE",
"Landorf KB"
] | Osborne JWA | Landorf KB | [
"Humans",
"Female",
"Middle Aged",
"Cross-Sectional Studies",
"Magnetic Resonance Imaging",
"Male",
"Muscle, Skeletal",
"Adult",
"Heel",
"Foot",
"Case-Control Studies",
"Fasciitis, Plantar"
] | [
"Journal Article",
"Observational Study"
] | 19 | 3 | e70183 | pmc-id: PMC13428631; | 1757-1146 | eng | https://pubmed.ncbi.nlm.nih.gov/42541750/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42541517 | 10.1007/s10689-026-00595-8 | Mainstream and fast-track genetic testing in pancreatic cancer patients and its impact on treatment: our experience in a tertiary hospital in Spain | Pancreatic cancer (PC) is a highly lethal malignancy. 4-10% are linked to inherited mutations in genes such as BRCA1/2, PALB2, ATM and mismatch repair (MMR) genes. Germline testing is essential to guide treatment decisions, yet delays remain common. Genetic testing models without pre-test assessment in a Hereditary Can... | Fam Cancer | Familial cancer | 2026 Aug 1 | 2,026 | [
"Bringas M",
"Echavarría I",
"Polo C",
"Jiménez-Alduán N",
"Flores C",
"Muñoz A",
"Ortega L",
"Torres G",
"Soto-Alsar J",
"Calvo A",
"Alfonso PG",
"Pajares JA",
"Suárez-González J",
"Del Monte-Millán M",
"Massarrah T",
"de la Peña FA",
"Martín M",
"Márquez-Rodas I"
] | Bringas M | Márquez-Rodas I | [
"Humans",
"Genetic Testing",
"Pancreatic Neoplasms",
"Female",
"Male",
"Middle Aged",
"Spain",
"Retrospective Studies",
"Tertiary Care Centers",
"Aged",
"Germ-Line Mutation",
"Genetic Counseling",
"Fanconi Anemia Complementation Group N Protein",
"Genetic Predisposition to Disease",
"BRC... | [
"Journal Article",
"Observational Study"
] | 25 | 3 | null | null | 1389-9600 | eng | https://pubmed.ncbi.nlm.nih.gov/42541517/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42540990 | 10.23889/ijpds.v11i5.3634 | RELEASE: demographic and criminological differences in post-imprisonment mental health and substance use-related service use | To (1) describe the demographic, health∗ and criminological characteristics of people released from prison; (2) examine their associations with post-imprisonment service use. Retrospective observational cohort study of all individuals released from Scottish prisons in 2015 (n = 8,313). Scottish Prison Service data were... | Int J Popul Data Sci | International journal of population data science | 2026 | 2,026 | [
"Savinc J",
"Kjellgren R",
"Connell C",
"Dougall N",
"Kurdi A",
"Leyland A",
"Watson J",
"Hunt K"
] | Savinc J | Hunt K | [
"Humans",
"Female",
"Male",
"Scotland",
"Retrospective Studies",
"Substance-Related Disorders",
"Mental Disorders",
"Prisoners",
"Adult",
"Mental Health Services",
"Middle Aged"
] | [
"Journal Article",
"Observational Study"
] | 11 | 5 | 3634 | pmc-id: PMC13426706; | 2399-4908 | eng | https://pubmed.ncbi.nlm.nih.gov/42540990/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42540903 | 10.23889/ijpds.v11i5.3525 | Fuel Poverty Interventions and Healthcare Usage: Insights from Warm Wales | Warm Wales (WW) is a community-based programme addressing fuel poverty and its broader impact on health and well-being. Interventions combine tailored energy advice, practical support, and education with wellbeing and social prescribing projects to improve health outcomes. Fuel poverty is closely linked to poorer healt... | Int J Popul Data Sci | International journal of population data science | 2026 | 2,026 | [
"Alshams M",
"Bentley L",
"Peh J",
"Greene G",
"Davies A",
"Akbari A",
"Newman C",
"Davies O",
"Taylor-Collins E",
"Dundon J"
] | Alshams M | Dundon J | [
"Humans",
"Wales",
"Longitudinal Studies",
"Poverty",
"Female",
"Male",
"Middle Aged",
"Housing",
"Primary Health Care",
"Socioeconomic Factors",
"Social Prescribing"
] | [
"Journal Article",
"Observational Study"
] | 11 | 5 | 3525 | pmc-id: PMC13426600; | 2399-4908 | eng | https://pubmed.ncbi.nlm.nih.gov/42540903/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42539800 | 10.3389/fpubh.2026.1898158 | Students' knowledge, perceived access, and attitudes toward population health integration in undergraduate nursing education | To address the growing population health challenges, the nursing workforce is expected to possess competencies of population health, which has been officially included as a new essential component in nursing and strongly advocated by nurse educators worldwide. However, no previous studies have explored the relevant opi... | Front Public Health | Frontiers in public health | 2026 | 2,026 | [
"Wang L",
"Wang J"
] | Wang L | Wang J | [
"Humans",
"Cross-Sectional Studies",
"Female",
"Male",
"Students, Nursing",
"Health Knowledge, Attitudes, Practice",
"Education, Nursing, Baccalaureate",
"Surveys and Questionnaires",
"China",
"Population Health",
"Adult",
"Young Adult",
"Curriculum",
"Attitude of Health Personnel"
] | [
"Journal Article",
"Observational Study"
] | 14 | null | 1898158 | pmc-id: PMC13424291; | 2296-2565 | eng | https://pubmed.ncbi.nlm.nih.gov/42539800/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42539687 | 10.3389/fcimb.2026.1874210 | Diagnostic value of metagenomic next-generation sequencing in deep neck space infections: a retrospective study of 32 patients | Deep neck space infections (DNSI) are rapidly progressive suppurative conditions in which early identification of causative pathogens is critical for clinical decision-making. This study evaluated the diagnostic performance and clinical utility of metagenomic next-generation sequencing (mNGS) in patients with DNSI. In ... | Front Cell Infect Microbiol | Frontiers in cellular and infection microbiology | 2026 | 2,026 | [
"Wang Z",
"Yang H",
"Liu J",
"Li X"
] | Wang Z | Li X | [
"Humans",
"High-Throughput Nucleotide Sequencing",
"Retrospective Studies",
"Metagenomics",
"Neck",
"Female",
"Male",
"Bacteria",
"Middle Aged",
"Aged",
"Bacterial Infections",
"Adult",
"Aged, 80 and over",
"DNA, Bacterial"
] | [
"Journal Article",
"Observational Study"
] | 16 | null | 1874210 | pmc-id: PMC13423987; | 2235-2988 | eng | https://pubmed.ncbi.nlm.nih.gov/42539687/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42538792 | 10.2519/jospt.2026.13563 | Changes in Pain-Related Fear Predict Shoulder Disability in Rotator Cuff Tendinopathy With Resistance Exercise | OBJECTIVE: To determine the trajectory of (1) change in pain-related fear and catastrophizing factors, (2) changes in pain-related fear and catastrophizing by treatment satisfaction groups, and (3) the relationship between pain-related fear trajectories, and catastrophizing factors and shoulder disability during an 8-w... | J Orthop Sports Phys Ther | The Journal of orthopaedic and sports physical therapy | 2026 Aug | 2,026 | [
"Mears CK",
"Heindel MD",
"Abeles RE",
"Vila-Dieguez O",
"Beneciuk JM",
"Michener LA"
] | Mears CK | Michener LA | [
"Humans",
"Female",
"Male",
"Prospective Studies",
"Middle Aged",
"Catastrophization",
"Fear",
"Longitudinal Studies",
"Resistance Training",
"Tendinopathy",
"Disability Evaluation",
"Shoulder Pain",
"Pain Measurement",
"Adult",
"Patient Satisfaction",
"Kinesiophobia",
"Aged",
"Rot... | [
"Journal Article",
"Observational Study"
] | 56 | 8 | 546-554 | null | 0190-6011 | eng | https://pubmed.ncbi.nlm.nih.gov/42538792/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42538737 | 10.1097/CCE.0000000000001413 | Amino Acid Deficiency Secondary to Continuous Venovenous Hemofiltration in Acute Decompensation of Organic Acidemias: An Anabolic Dead End? | To evaluate the impact of continuous renal replacement therapy (CRRT) on plasma amino acid (AA) concentrations in patients with acute metabolic decompensation of organic acidemias (OAs), and to explore whether AA supplementation during CRRT may mitigate AA depletion. Multicenter retrospective observational study. PICUs... | Crit Care Explor | Critical care explorations | 2026 Aug 1 | 2,026 | [
"Grosyeux C",
"Cammiciotto N",
"Jeannesson E",
"Feigerlova E",
"Villada V",
"Wicker C",
"Levy M",
"Schiff M",
"Imbard A",
"Coelho D",
"Feillet F",
"Wiedemann A"
] | Grosyeux C | Wiedemann A | [
"Humans",
"Amino Acids",
"Continuous Renal Replacement Therapy",
"Retrospective Studies",
"Male",
"Female",
"Middle Aged"
] | [
"Journal Article",
"Multicenter Study",
"Observational Study"
] | 8 | 8 | e1413 | null | 2639-8028 | eng | https://pubmed.ncbi.nlm.nih.gov/42538737/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42538675 | 10.6002/ect.MESOT2025.O58 | Therapeutic Plasma Exchange in Pediatric Transplant and Organ Failure: Analysis of Indications, Adverse Events, and Clinical Outcomes | Therapeutic plasma exchange has become an increasingly important extracorporeal therapy in pediatric intensive care and transplant settings. However, evaluations in large real-world pediatric cohorts of its effectiveness and safety across multiple indications remain limited. In this 5 -year single -center study, we pro... | Exp Clin Transplant | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation | 2026 Jul | 2,026 | [
"Baskın E",
"Dönger U",
"Siddiqui MA",
"Özçay F",
"Sahin Eroglu E",
"Şafak A",
"Karakaya E",
"Haberal M"
] | Baskın E | Haberal M | [
"Humans",
"Plasma Exchange",
"Child",
"Female",
"Child, Preschool",
"Male",
"Retrospective Studies",
"Treatment Outcome",
"Infant",
"Adolescent",
"Risk Factors",
"Infant, Newborn",
"Time Factors",
"Organ Transplantation",
"Age Factors",
"Turkey",
"Critical Illness",
"Risk Assessmen... | [
"Journal Article",
"Observational Study"
] | 24 | Suppl 2 | 166-171 | null | 1304-0855 | eng | https://pubmed.ncbi.nlm.nih.gov/42538675/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42538555 | 10.1186/s12879-026-14111-x | A multicenter prospective observational multi-omics study protocol to identify biomarkers for severe dengue: COMBAT study clinical protocol | Dengue virus (DENV) infection poses a major global public health burden, particularly in endemic regions where repeated exposure increases the risk of severe disease. Despite revisions to the World Health Organization (WHO) dengue classification, early prediction of progression to severe dengue remains challenging due ... | BMC Infect Dis | BMC infectious diseases | 2026 Jul 31 | 2,026 | [
"Mudgal PP",
"Veliz SPZ",
"Lourda M",
"Kadni TS",
"Varma M",
"Mazumder A",
"Budhiraja S",
"Jaggi N",
"Mukhopadhyay C",
"Sengupta S",
"Maitra A",
"Hug K",
"Sinha I",
"Ambikan AT",
"Filipovic I",
"Neogi U",
"COMBAT consortium"
] | Mudgal PP | Neogi U | [
"Humans",
"Biomarkers",
"Multiomics",
"Prospective Studies",
"India",
"Severe Dengue",
"Guatemala",
"Longitudinal Studies",
"Metabolomics",
"Proteomics",
"Dengue Virus",
"Female"
] | [
"Journal Article",
"Observational Study",
"Multicenter Study"
] | 26 | 1 | null | pmc-id: PMC13428414; | 1471-2334 | eng | https://pubmed.ncbi.nlm.nih.gov/42538555/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42538338 | 10.1038/s41598-026-63797-1 | Integrating validated scores with clinical parameters to predict NIV weaning outcomes: a prospective study in the respiratory ICU | Early prediction of successful weaning from non-invasive ventilation (NIV) remains challenging in patients with acute respiratory failure. This study evaluated clinical, laboratory, and severity-score predictors of NIV weaning outcomes among patients admitted to the Respiratory Intensive Care Unit (RICU). This prospect... | Sci Rep | Scientific reports | 2026 Jul 31 | 2,026 | [
"Gadallah D",
"Esmaeel HM",
"Mahmoud HA",
"Khalaf AR"
] | Gadallah D | Khalaf AR | [
"Humans",
"Ventilator Weaning",
"Prospective Studies",
"Female",
"Intensive Care Units",
"Male",
"Respiratory Insufficiency",
"Noninvasive Ventilation",
"Middle Aged",
"Aged",
"APACHE",
"Cross-Sectional Studies",
"Respiratory Care Units"
] | [
"Journal Article",
"Observational Study"
] | 16 | 1 | null | pmc-id: PMC13427732; | 2045-2322 | eng | https://pubmed.ncbi.nlm.nih.gov/42538338/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42538123 | 10.1136/bmjpo-2026-004976 | High levels of parenting stress and trauma despite age-appropriate developmental outcomes following perinatal asphyxia: a cross-sectional observational study | To examine the association of perinatal asphyxia across mild to moderate hypoxic-ischaemic encephalopathy (HIE) severity levels and therapeutic hypothermia (TH) with child developmental outcomes and parenting stress and to explore parental trauma and psychosocial support. Multicentre, cross-sectional, comparative obser... | BMJ Paediatr Open | BMJ paediatrics open | 2026 Jul 31 | 2,026 | [
"Sutterer-Verrelli A",
"Georg AK",
"Riecker A",
"Weiss VB",
"Puchwein-Schwepcke AF",
"Nussbaum C"
] | Sutterer-Verrelli A | Nussbaum C | [
"Humans",
"Cross-Sectional Studies",
"Female",
"Asphyxia Neonatorum",
"Male",
"Infant",
"Stress, Psychological",
"Parents",
"Infant, Newborn",
"Parenting",
"Child, Preschool",
"Hypoxia-Ischemia, Brain",
"Germany",
"Hypothermia, Induced",
"Child Development",
"Social Support",
"Survey... | [
"Journal Article",
"Observational Study",
"Multicenter Study",
"Comparative Study"
] | 10 | 1 | null | null | 2399-9772 | eng | https://pubmed.ncbi.nlm.nih.gov/42538123/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
42538112 | 10.1136/bmjopen-2025-116064 | COVID-19 cluster outbreaks and infection control measures in nursing homes in Okinawa: protocol for a retrospective observational study | Following the reclassification of COVID-19 as a category V infectious disease in Japan in May 2023, systematic public health monitoring of case numbers and cluster outbreaks was discontinued. Consequently, infection control measures, responses to cluster outbreaks and vaccination coverage in long-term care facilities w... | BMJ Open | BMJ open | 2026 Jul 31 | 2,026 | [
"Ideguchi S",
"Takayama Y",
"Ikemiyagi N",
"Ujimiya F",
"Yamaniha K",
"Imura M",
"Tanabe K",
"Yamamoto K"
] | Ideguchi S | Yamamoto K | [
"Humans",
"Japan",
"Nursing Homes",
"Retrospective Studies",
"Infection Control",
"COVID-19",
"Disease Outbreaks",
"SARS-CoV-2",
"Nursing Home Residents",
"Aged"
] | [
"Journal Article",
"Observational Study"
] | 16 | 7 | e116064 | null | 2044-6055 | eng | https://pubmed.ncbi.nlm.nih.gov/42538112/ | kwxd6qpxpJE14TaP7 | B1q1x9UqSznjcCe2h |
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