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Previous studies have attempted to determine whether aseptic loosening and osteolysis are caused by a T cell-mediated type IV hypersensitivity reaction or a nonspecific foreign body reaction involving phagocytic macrophages. The purpose of this study was to examine the role of the B7-CD28 costimulatory pathway (which is indicative of an activated immune response) in loosening and osteolysis of total joint replacements (TJRs). We harvested periprosthetic tissues from 24 loose, cemented, all polyethylene, acetabular components in patients undergoing revision total hip replacement surgery for aseptic loosening. Prostheses were classified radiographically as to whether ballooning, scalloping osteolysis was present or not. Monoclonal antibodies were used to identify macrophages, antigen presenting cells (APCs) expressing B7-1 or B7-2, total T lymphocytes, and T cells expressing CD28 or CTLA-4. The large numbers of positive cells, including macrophages, T cells, and APCs in both groups are substantially higher than previously reported. Macrophages constituted the predominant cell type, the majority of which were APCs. B7-1 was expressed by 18.3% of all cells, and B7-2 was expressed by 61.0% of cells. Despite the fact that there were no statistically significant differences in expression of proteins in the B7-CD28 pathway between the osteolytic and nonosteolytic groups, the magnitude of positive staining suggests that the process of aseptic loosening (not osteolysis) may involve proteins of the B7-CD28 pathway, particularly B7-2. One possible antigenic stimulus is protein-coated particulate wear debris from prosthetic materials. |
View details for Web of Science ID 000167677200021 |
View details for PubMedID 11255198 |
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Tom Cruise and Suri Reunite in NYC! |
Tom Cruise, Suri Cruise James Devaney/WireImage |
Tom Cruise is a lot of things. Doting father is one of them. Good Samaritan is another. So it's hardly surprising that he was reunited with daughter Suri in New York City just hours after she and Katie Holmes escaped uninjured from a fender-bender. |
Frankly, we'd be surprised if the knight in shining armor hadn't popped up in the Big Apple this morning to spend time with his 6-year-old for the first time since word of their split broke more than two weeks ago. |
MORE: Suri and Katie sideswiped! |
While getting caught by the paparazzi was inevitable, the 50-year-old movie star didn't stay out in public for too long, and was only briefly spotted while carrying Suri (herself carrying a stuffed animal) from his car to their hotel. He only arrived in the city this morning. |
A source confirms that this is the first scheduled visitation between the duo, but that while they have not physically been in the same place, there has been "near daily" contact between the father and daughter. In any case, today's face time is no doubt preferable to what was originally on the books, as today was the scheduled date for the first hearing (canceled in light of a settlement) between Tom and Katie. |
Though Suri and mama Katie have been making the rounds in NYC on a daily basis, Cruise has spent the past two weeks filming his new sci-fi flick Oblivion in California. |
From the adorable look of things, they've clearly missed each other's company. |
PHOTOS: Katie Holmes Post-Split |
Most fitting nicknames? |
#1LightningAce11Posted 1/18/2013 2:25:32 AM |
I saw a zapdos named badhairday. |
Official Zapdos of the Pokemon X/Y Message Boards |
#2HemerukioPosted 1/18/2013 2:26:40 AM |
Magikarp named God. |
#3MilenninPosted 1/18/2013 2:27:34 AM |
Bidoof = Biderp |
#4darkdragongirlPosted 1/18/2013 2:31:12 AM |
Named my Scrafty after the character in "The Stranger". Mersault just wants to enjoy a good smoke, and watch some executions. |
Playing: Ragnarok Odyssey |
I've got a poring on my mind, and toast in my mouth, let's quest! |
Take the 2-minute tour × |
I have an issue with a certificate authority in a windows 2003 domain. We need one configured to allow ssl/tls encrypted traffic over LDAP so that our Application Gateway server is able to allow users to change domain passwords. |
I do not have a lot of knowledge on certificates and the server functions of a CA. |
We have had a CA setup on a domain server that is not a domain controller. This appears to be fine. However, when trying to add a new Automatic Certificate Request under the Public Key Policies section, I get strange results. |
When carrying out this action I choose the Domain Controller Certificate template and hit next I get the following screen: |
alt text |
I would actually expect to be able to choose the CA server at this point. Clicking finsh, closes the wizard and there are no more options to choose from. Can anyone suggest some diagnostic steps I can take? |
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1 Answer |
up vote 1 down vote accepted |
The templates you see in the Automatic Setup are determined by the security settings on the Certificate Templates on your CA server(s). Most computers can only get the Computer certificate because of how the security defaults. Another option open to you is to use the Certificate MMC to request it on the DC itself. |
1. Start -> Run -> MMC |
2. Add the "Certificates" snap-in, for the Computer Account |
3. Open the "Personal" store |
4. Right click on "Certificates" and go to All Tasks -> Request New Certificate |
5. This will give you a short list. On a DC it should have a "Domain Controller" option Pick it. |
6. Go through the wizard |
You should get a Domain certificate that'll be used for LDAPS. |
However, if you DO NOT have an Enterprise CA you won't have some of these templates. A "Standalone CA" doesn't have the same features as the above. I don't have a lot of experience with those so I can't guide you. |
share|improve this answer |
Thanks for the suggestion - looks like that will do it. Will doing this cause anything untoward to happen? (will accept answer shortly) – Kip Sep 3 '09 at 14:58 |
How it's supposed to work is that the certificate presented by the SSL-secured services on the DC will start using that certificate. Anything in the domain should have the root of your tree in their trusted roots list just by being in the domain. It's the non-domained machines that'll throw SSL-validation fits if they don't have the CA cert. – sysadmin1138 Sep 4 '09 at 6:09 |
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SI Vault |
A Look Of Greatness |
Paul Zimmerman |
October 29, 1984 |
With quarterback Dan Marino overseeing a brilliant offense, Miami crushed New England to stay unbeaten |
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October 29, 1984 |
A Look Of Greatness |
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Careful now, it's going to be easy to get carried away by all of this. Let's keep it in perspective. |
The Miami Dolphins were not the perfect offensive machine Sunday in their 44-24 victory over the New England Patriots in Foxboro, Mass. They had an extra point blocked. Dan Marino threw an interception. They punted once. They had the ball for nine possessions and they scored only seven times. What's that you say? Seven scores in nine possessions is enough to win any game that's ever been played since Pop Warner was a water boy? But we're looking for perfection here, and the only thing perfect about the Dolphins is their record, 8-0. The last time they got off to a start like this was 1972, and they were never stopped. That ended at 17-0 and a Super Bowl victory. |
It was an entirely different animal that Don Shula had in those days. It ranked with the old Lombardi Packers as the best-balanced offense the game had ever seen. The Dolphins could hammer you to death with Larry Csonka and Jim Kiick running behind an All-Pro middle threesome of Larry Little, Jim Langer and Bob Kuechenberg, and for flash and dash they had Mercury Morris. This cast produced the most rushing yards ever in one season, up to that point. When they wanted to air it out there was All-Pro Bob Griese throwing to a Hall-of-Famer, Paul Warfield, and their defense was a cerebral affair, keyed to the emerging genius of Bill Arnsparger and his new 53 concept and operated by a superb middle linebacker, Nick Buoniconti, and the All-Pro safetymen Dick Anderson and Jake Scott. The names glitter like diamonds. Talent, ball control, smarts, 17-0. Would there ever be anything to match it? |
Shula won't compare this team with the '72 Dolphins. It's a sucker's game. The season is only half over, and who knows what perils lie ahead? So we'll do it for him. For the first six games, while the world was marveling at Marino gunning the ball and the twin Marks—Duper and Clayton—catching it two zip codes away, the whispers were starting. It's not a typical Shula-type team; it's all whoosh and no muscle. It's not the kind of team he's comfortable with. He's like a coachman with a team of runaway horses. All he can do is give 'em their head. Why else would he pick up a 265-pound cartoon-character of a fullback, Pete Johnson, a guy two teams, Cincinnati and San Diego, had given up on? His running game is nowhere, and sooner or later that will catch up with him. |
Two weeks ago, halfback Tony Nathan went down with a strained hamstring, and Shula plugged in rookie Joe Carter, a fourth-round draft choice from Alabama. He went for 105 yards against the Oilers. It was the first time a Dolphin runner had made a hundred since 1982, but what the hell, it was Houston. People do what they want to the Oilers. |
New England isn't Houston. The Patriots, who went into the Miami game at 5-2, are a proud bunch, with one of the best defensive coordinators, Rod Rust. They are a team with a fine old pro at inside linebacker, Steve Nelson; an emerging terror at an outside backer spot, Andre Tippett; and a solid cover man at the right corner, Raymond Clayborn. Let's see 'em do it to the Patriots. |
What happened was scary. The Dolphins piled up 552 yards, tying their club record. Marino twisted down the choke on his long ball and threw for 316 yards on 15- and 18-yarders. He scrambled. He bought time. He looked the defenders off, and with his remarkable field of vision, he always seemed able to find the open man. He'd gallop, shake off a tackier, pull up and flick the ball. |
Two lasting vignettes: Marino shrugging off blitzing linebacker Larry McGrew, who'd taken dead aim on him, and firing the ball to Carter for nine yards; Marino, one step away from the charging 271-pound Kenneth Sims, motioning his tight end, Dan Johnson, to go deeper, and then drilling the ball 16 yards to him on the dead run, down to the one-yard line. |
"We should have had four or five sacks today," Patriot defensive end Doug Rogers said. "How does a guy like that escape, as big as he is?" |
Marino is 6'3", 214 pounds, and his toes don't twinkle, but somehow he avoided every kind of rush New England mustered. He went unsacked on the afternoon; he has tasted the canvas only twice all season, which is just one of a laundry list of shocking statistics the Dolphins can throw at you. How about this one? Marino's four touchdown passes Sunday gave him 24 for the year—two more than Griese's club record—and the season is only half over. |
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Parasites Like Us |
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The debut novel by the author of The Orphan Master's Son, winner of the 2013 Pulitzer Prize for Fiction |
Hailed as "remarkable" by the New Yorker, Emporium earned Adam Johnson comparisons to Kurt Vonnegut and T.C. Boyle. In his acclaimed first novel, Parasites Like Us, Johnson takes us on an enthralling journey through memory, time, and the cost of mankind's quest for its own past. |
Anthropologist Hank Hannah has just illegally exhumed an ancient... |
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Editorial Reviews |
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Barnes & Noble Discover Great New Writers |
Johnson's wry first novel is a satire of academia, complete with an apocalyptic twist for unsuspecting readers. Anthropologist Hank Hannah takes special pride in the work of his students. His star pupils include Eggers, living for an entire year as a member of the "Clovis," a prehistoric civilization, and Trudy, whose theories relate to the artistic legacy this primeval society may have left behind. As Eggers and Trudy bicker over scientific theories and financial grants, Hannah addresses some issues of his own: his recently widowed and seemingly sex-starved father, and Hannah's own attempts to apply historical reasoning to modern romance. |
When Eggers unearths an ancient Clovis spearhead, he teams up with Hannah and Trudy on a clandestine mission yielding disastrous results for humankind. Hannah reflects on the demise of his own species: "The successful forms of life are the parasites, the ones who bleed their environment to optimal exploitation, who stunt everything by taking a lion's share, who leave their hosts alive but shriveled." With the future of humanity left to just a handful of comrades (academics, no less!), the studious triumvirate apply their understanding of an extinct civilization in an effort to bring about the dawn of a new age. Johnson has penned a darkly visionary novel, with keen insights and just enough pathos to keep readers enthralled. (Fall 2003 Selection) |
The Washington Post |
… [Johnson's] characters are wonderfully weird and charming, and he is so witty a storyteller that this strange novel manages to captivate. — Carmela Ciuraru |
The New York Times |
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