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The Falcon 9's first stage came back to Earth for a vertical touchdown at Vandenberg about 7.5 minutes after liftoff. It was the 12th launch and landing for this particular booster, according to a SpaceX mission description.
The mission carried 90 payloads for a variety of different customers, "including cubesats, microsats, and orbital transfer vehicles carrying spacecraft to be deployed at a later time," the mission description reads.
These payloads will be deployed into low Earth orbit between 54 and 85.5 minutes after liftoff, according to the mission description.
Ninety is a hefty number to be sure, but it isn't close to a record. SpaceX's Transporter-1 mission holds the mark, sending 143 satellites to orbit in January 2021. And Transporter-6, which lifted off this past January, was also more prolific, carrying 114 satellites aloft.
Transporter-9 is the 82nd orbital mission for SpaceX in 2023, extending the company's record for a single year. (The previous mark, 61 launches, was set in 2022.) Most of this year's missions have been devoted to building out Starlink, SpaceX's internet megaconstellation, which currently consist of more than 5,000 | eng | 9fc9700f-d2d6-44ad-812e-837461e3e9e8 | https://satellitenewsnetwork.com/spacex-launches-90-payloads-into-orbit-on-rideshare-mission/ |
SVG Files
Working with SVG Files
Working with SVG (Scalable Vector Graphics) files is very similar to working with text, except that you need to select a SVG file.
If you want to create your own file, you must use a vector based application like Illustrator or Inkscape and export an SVG file. The only constraint is that the SVG file needs to contain closed shapes with no open curves.
If you have never worked with the SVG format and its shapes before, an easy way to understand how shapes are built is to simply download a file online and look at it with your favorite vector based 2D software. You'll learn the principles very quickly. | eng | 4c0783b6-cb68-4223-b333-77f36b655c71 | http://docs.pixologic.com/user-guide/zbrush-plugins/text-3d-vector-shapes/svg-files/ |
Hey Mozzers,
How would you structure the following pages for SEO. The site is a multi-product / multi-topic site, but all pages in this example are based on a single topic - CRM Software:
CRM Software product
CRM Software related blog post 1
CRM Software related blog post 2
CRM Software related blog post 3
CRM Software downloadable resource 1
CRM Software downloadable resource 2
CRM Software downloadable resource 3
I know building directory pyramids is a bit old hat nowadays, but I still see the odd website organising the above pages, as follows:
/crm-software
/crm-software/crm-blog-post-1
/crm-software/crm-blog-post-2
/crm-software/crm-blog-post-3
/crm-software/crm-resource-1
/crm-software/crm-resource-2
/crm-software/crm-resource-3
However, I'm more inclined to apply a more logical structure, as follows:
/crm-software
/blog/crm-blog-post-1
/blog/crm-blog-post-2
/blog/crm-blog-post-3
/resources/crm-resource-1
/resources/crm-resource-2
/resources/crm-resource-3
What would you say is SEO best practice?
Thanks!I'm trying to get rid of a Google penalty, but one of the URLS is particularly bizarre.
Here's the penalized site:
One of the external links Google cited as not being natural that links to the penalized site is:
In the backlink profile of the penalized site, there are about 100 different backlinks pointing to from content.onlineagency.com/...
So when I visit it actually is displaying content from which you can see after clicking the "Home" button. That company is a legit travel agency who I assume knows nothing about content.onlineagency.com and is not involved in whatever is going on.
And that's the case for every link from content.onlineagency.com.
So I'm just wondering if someone can help me understand what sort of tactic content.onlineagency.com is using. One of my predecessors I fear used some black hat tactics. I'm wondering if this is a remnant of that effort.The site is
It's a really small site
They have only about 7 back links,
They don't blog
They don't have a PPC campaign
They don't stand out from the crowd in terms of product or services offered
So why are they succeeding in topping the SERP's for difficult to rank for accounting keywords such as accountant and online accounts. What are they doing better than everyone else, or have they discovered a way to cheat Google, and worse still - ME!
Content is syndicated legally (licensed). My questions are:
What is the best way to approach this situation?
Is there any a change to compete with the original site/page for the same keywords?
Is it okay to do so? Will there be any negative SEO impact on my site? | eng | 4511d0ef-0554-423b-bd1a-9e44967cb056 | https://moz.com/community/q/topic/22939/pages-getting-deindexed/4 |
Mannered AI
Giving robots a grounding in workplace etiquette.
From job interviews to water cooler chat, work life with robots will need some guidelines. Credit: Gremlin/Getty Images
Most of us – not all – figure out an approach to workplace behaviour while on the job and through trial and error.
Through the cut and thrust of everyday work we learn when it's the right time to talk to colleagues and when it isn't. We learn that some colleagues are happy to talk any time and some hardly at all, and that some don't ever want work conversations to stray into personal territory.
It's going to be increasingly important to "teach" such routine human skills to robotic systems as we move towards them filling a variety of human workplaces.
This isn't simply a matter of programming them to understand commands and to ask simple questions (think Siri). They have to learn about two-way communication – about saying what they're doing and hearing what others are doing so that everyone works together effectively.
With that in mind, researchers at Massachusetts Institute of Technology's (MIT) Computer Science and Artificial Intelligence Laboratory (CSAIL) have developed a framework called CommPlan, which gives robots a few high-level principles for good etiquette and then leaves it to them to make decisions that allow them to complete tasks as efficiently as possible.
CommPlan, they say, contrasts to more explicit, handcrafted communication policies that would see robots interacting using hard-and-fast rules based on specific probabilities. This difference between the two approaches is subtle but important.
CommPlan uses learning and planning algorithms to do real-time cost-benefit analyses on its decisions.
For example: will asking a human colleague a question save time by ensuring the robot doesn't do the wrong thing, or will it slow down a work process because it stops or slows the human from performing their task? The robot might weigh a combination of factors, such as whether the human is busy or likely to respond given past behaviour.
In contrast, a handcrafted policy essentially has to be designed anew for each task and context.
The MIT team tested three approaches – CommPlan, a handcrafted policy, and a communications-free silent policy – as part of a kitchen scenario involving tasks such as assembling ingredients, wrapping sandwiches and pouring juice.
Experiments, they say, showed that the human-robot teams performed more safely and efficiently using CommPlan compared to either of the other options.
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Vaibhav Unhelkar is one of the lead authors on a paper about CommPlan that will be (virtually) presented in coming days at the Association of Computing Machinery / Institute of Electrical and Electronics Engineers International Conference on Human-Robot Interaction.
He says he's encouraged by the success of CommPlan, since handcrafted policies require significant time, effort and expertise on the part of programmers.
"CommPlan combines the power of human experts and algorithms to create policies that are better and at the same time require reduced developer effort," he says.
Additionally, the researchers say that a handcrafted policy's reliance on cut-and-dried rules makes it more likely to suffer from hiccups such as overcommunication.
"Many of these handcrafted policies are kind of like having a co-worker who keeps bugging you on Slack, or a micromanaging boss who repeatedly asks you how much progress you've made," says co-author Shen Li.
"If you're a first responder in an emergency situation, excessive communication from a colleague might distract you from your primary task."
CommPlan's performance offers great promise for its applications in other domains, such as manufacturing and, especially, healthcare.
In a world feeling its way through the COVID-19 pandemic, in which healthcare workers are among the most vulnerable because of their need to interact with patients and one another – CommPlan could help speed the pace at which robots enter human workplaces to assist with tasks that would otherwise expose or endanger humans.
The CommPlan team has so far only used the framework for spoken language, but they say it could also be applied to visual gestures, augmented reality systems, and other approaches | eng | 5961b732-d6dc-419d-85fc-292b85210997 | https://cosmosmagazine.com/technology/mannered-ai/ |
--- Comment #2 from Oleh Hushchenkov <o.hushchenkov@gmail.com> ---
(In reply to Li-Wen Hsu from comment #1)
Don't know how it happened, two identical bug reports with the same reported
time.
Thanks for closing this.
--
You are receiving this mail because:
You are the assignee for the bug. | eng | da8966f2-5d2d-4f64-a198-1a4332d5b72b | https://lists.freebsd.org/archives/freebsd-chromium/2021-May/000006.html |
What is hafnium
Hafnium is a chemical element that has the atomic number 72. It has an atomic mass of 178.48 g/mol and it is represented by the symbol Hf. It is a d-bock element and in period 6 group 4 of the periodic table. There are 72 electrons, 72 protons and 106 neutrons in an electrically neutral atom of hafnium. The electronic configuration of hafnium is 1s2, 2s2, 2p6, 3s2, 3p6, 3d10, 4s2, 4p6, 4d10, 5s2, 5p6, 4f14, 5d2, 6s2. The oxidation of hafnium is −2, 0, +1, +2, +3, +4. The electronegativity of hafnium is 1.3 (Pauling scale). There are five stable isotopes of hafnium that are naturally occurring. Some thirty-one radioisotopes of hafnium exist at the moment. The long-lived radioisotope of hafnium is Hf-174.
Hafnium has a white grayish colour. Chemically hafnium is similar to zirconium. It is a ductile metal and resists corrosion. At STP it is in solid form and has a density of about 13.31 g/cm3. Its melting point is 2506 K ?(2233 °C, ?4051 °F) and its boiling point is 4876 K ?(4603 °C, ?8317 °F).
Hafnium was predicted in 1869 by the Russian Dmitri Mendeleev. It was first discovered and isolated by Dirk Coster and George de Hevesy in 1922. The element was named after the capital of Denmark. The Latin name for the city was Hafnia.
Hafnium does not exist as free. It found within natural zirconium compounds. The min source of Hafnium is heavy mineral sands ore deposits, pegmatites and carbonatite. These ores can be found in countries like Australia, Brazil and Malawi.
Some of the following are the applications of the element Hafnium and its Compounds.
Hafnium is used in alloys with niobium, tantalum, iron, titanium as well as other metals. About 10% of hafnium is used in alloys which are used for liquid rocket thruster nozzles. It improves the corrosive resistance of the alloy. Hafnium compounds are used in gate insulations of integrated circuits of microprocessors. Hafnium is used as a neutron absorber in nuclear reactors. It has a high cross-section area for neutron capture. Hafnium metallocene compound is used as a catalyst in the production of polyethylene and polypropylene. Hafnium isotopes are used in lutetium-hafnium dating which is used in geochronological applications.
It found within natural zirconium compounds. The main source of Hafnium is heavy mineral sands ore deposits, pegmatites and carbonatite. These ores can be found in countries like Australia, Brazil and Malawi. | eng | f3c4a3aa-bbbe-4c78-a256-8072764dfe16 | https://mixsaver.com/article/what-hafnium/ |
NCERT Books for Class 9 2023 - Students can download the Class 9 NCERT books of all the subjects including Maths, Science, Social Science, Hindi, English, etc. from the links provided in this article below. These Class 9 NCERT books pdf can also be download from the official website - ncert.nic.in. Students can also purchase the Class 9th NCERT Books from their nearest bookstore. NCERT Class 9 books are designed as per the National Curriculum Framework (NCF). All the CBSE affiliated schools and some other state board schools prescribe NCERT books in their curriculum.
NCERT 9th class books are available in the Hindi and English language. The NCERT Books for class 9 contains chapters and practice questions for better understanding of concepts. The language of books is simple and easily understandable. All the topics are explained well through proper diagrams and examples. Students should refer to the class 9 NCERT books and NCERT Class 9 Solutions to score well in the examination.
How to Download NCERT Books for Class 9 2023?
NCERT Books are available online in PDF format on the official website of NCERT. Students can download chapter wise PDFs of each subject online. Check the step by step procedure to download the NCERT Books for class 9 online.
Step 1 - Visit the official website of NCERT, ncert.nic.in.
Step 2 - On the header section, click on 'Publications' and then click on the 'ebooks' and 'PDF (I - IIX).
Step 3 - Now select 'class IX', Subject and name of the textbook.
Step 4 - The list of chapters will appear on your screen. Download the chapters in PDF format.
For Science, NCERT publishes one single book which covers all three sections Physics, Chemistry, and Biology.
There are a total of 15 chapters included in the NCERT book for class 9 science.
Matter in our surroundings, Atoms and molecules, The fundamental unit of life, Diversity in living organisms, Force and laws of motion, Sound, Improvement in food resources are some of the chapters included in the class 9 Science NCERT book.
The chapters contain all the prescribed topics in a well explanatory form.
All the important topics are explained with the help of relevant diagrams and flow charts. | eng | 5f22c417-0122-4530-a50c-cf01f961fa5d | https://school.careers360.com/ncert/ncert-books-for-class-9 |
Learning how to plant bulbs in pots is a real gardening game changer. Simple to do but hugely rewarding, it's possible to create a color filled feature in minutes that will provide weeks and months of joy.
Whether you are new to gardening or usually only plant bulbs in borders, know that most flowering bulbs will thrive happily in a pot. Provide them with their ideal soil, food and growing conditions and they will reward you with a show of gorgeous blooms. Whether you are looking to plant up a large statement pot with a succession of spring bulbs or a neatly curated group showcasing summer bulbs, there are endless possibilities to explore.
'Bulbs with larger, extravagant flowers work particularly well in containers as they deliver a concentrated burst of color in your garden, however most bulbs will create a beautiful display,' says James Ramnought, from Phostrogen (opens in new tab).
Growing bulbs in pots is also useful if space is tight. Tiered metal staging, neat planter boxes are all brilliant for injecting color into a smaller area and as bulbs need little attention it's a real easy win. Change the display regularly, depending on what's coming into flower and use to highlight a tabletop, a flight of steps or cluster around an entranceway. Whatever your plans for planting bulbs in fall and beyond, we've rounded up the best and most helpful expert tips to inspire and refresh your yard.
How to plant bulbs in pots
(Image credit: Leigh Clapp)
To ensure good drainage, layering any container for planting is key to success. Most flowering bulbs require good drainage as they simply hate sitting in waterlogged soil. To prevent rot from setting in choose a container with one large or multiple holes in the base. Line the base with broken crock or polysterene chips and a thin layer of grit before adding compost.
Use a special bulb-planting compost (your local plant nursery will sell this or Miracle-Gro is highly rated on Amazon (opens in new tab)), as this is specially formulated to hold on to moisture and vital nutrients while still providing good drainage.
Fill the container halfway with compost before planting up. Lifestyle blogger Pamela Groppe of Flower Patch Farmhouse (opens in new tab) advises, 'If you are going for a thick display of one variety, plant your tulip bulbs or other bulbs more closely together and a little shallower than recommended on the package. Just make sure your have at least 2in of soil depth for the roots.'
Plant winter flowers over the bulbs. 'Where I live,' says Pamela, 'I can leave my containers outside all winter long. So instead of just looking at dirt I plant some violas or pansies on top to enjoy before the bulbs begin to peek out.'
How to plant bulbs in pots using the 'lasagne' method
(Image credit: Leigh Clapp)
'If you're planting your bulbs in pots, lasagne planting is a popular method to get the most from them,' says Dan Dunbar, Hillier Bulb Expert (opens in new tab). 'Much like the dish it involves bulbs being planted in layers, so it is key to choose varieties with different planting depths.'
Choose three – or if you are feeling ambitious five – varieties of spring flowering bulb for a large container. Go for a selection that includes early, mid and late spring bloomers.
Starting with the larger later flowering bulbs plant them at roughly three times their height below the pot's brim.
To encourage growth and regeneration, Dunbar continues, 'Sprinkle a small amount of Bulb Starter (opens in new tab) under the bulbs when planting to encourage them to develop a secondary root system, this helps the plants take up more feed and regenerate the following year. Applying Fish, Blood & Bone (opens in new tab) as the bulbs start to die down also aids regeneration and will be a benefit to all bulbs.'
What to do when pot grown bulbs finish flowering
Pot planted bulbs tend to perform best in their first year so most gardeners tend to plant afresh each fall. This doesn't mean you have to discard the outgoing plants though.
Vanessa Elms of Old House Gardens Heirloom Bulbs (opens in new tab) says 'When the foliage yellows, empty the bulbs from the pots, dry completely, remove the foliage, and store in a cool, dry, well ventilated spot until it's time to replant them in the garden in the fall. Although they may not bloom the following year, with luck and good care they'll bounce back from their life in confinement and bloom again in future years.'
Do you water bulbs in pots over winter?
Bulbs outside in pots should be in moist soil, but that does not mean need to be watered over winter if the weather is wet off and on – just keep an eye on the soil. In really extended periods of wet weather, you may even need to protect bulbs so that they don't rot in the ground. Ideally, cover them or move them to a more protected spot during this time. Finally, never water pots when a freeze is predicted, which will kill your bulbs.
Can you leave bulbs in pots all year round?
You can leave bulbs in pots year round and many will rebloom again the next year. However, bulbs will fare better if dug out, cleaned up and put in a dry spot until planting season begins again. | eng | 480f2752-7e5c-4038-b646-f430e093dffa | https://www.homesandgardens.com/gardens/how-to-plant-bulbs-in-pots |
The term idiogram should not be confused with the term ideogram (a character that represents a specific object).
In idiograms, the dark areas always represent G-bands. The white areas represent the R-bands which do not accept the Giemsa dye . Areas made up of repetitive elements are sometimes shown hatched.
Idiograms are provided with standardized names for these chromosomal regions (banding). In humans, this designation is made up of the following elements: number or letter of the chromosome, p or q for the respective arm (p for petit), as well as numbers that count up from the centromere. For a finer distinction, the numbers can have several places. The figure shows the Y chromosome. The band Yp11.31 is therefore a sub-band of Yp11. The term "Yp" stands for the entire short arm of the Y chromosome. Centromere regions are also denoted by c (Yc). For the sake of simplicity, telomer areas are often referred to as tel (e.g. Yptel or Yqtel) and areas close to telomer as ter (Ypter | eng | faead540-b307-4bef-b59c-a73d8ac5fb7e | https://de.zxc.wiki/wiki/Idiogramm |
7 Books for an introduction to mindfulness
Mindfulness is something that many of us are trying to focus on a little more. After all, life is busy.
Whether you are a parent navigating the fog of life with kids, under pressure with a job, or struggling with things like your finances or relationships, mindfulness can be a great way to reaffirm your feelings and help you think more positively.
However, if you are wanting to be introduced to mindfulness then where should you start? I have found a few books that are well worth reading to help you grasp how you can incorporate mindfulness into your life.
The boy, the mole, the fox, and the horse – Charles Mackesy
This is such a lovely book to remind you to think a little differently. It is easy to understand and gives you insight in short bursts through beautiful images and very easy to digest forms of wording.
Using conversations between the four characters in different scenarios to highlight when you can think differently and in a positive way.
Ikigai: The Japenese secret to a long and happy life – Hector Garcia and Francesc Miralles
This book is a lovely insight into the Japanese concept of Ikigai and how it can help you have a sense of meaning with everything that you do. It will help you to approach things differently and rethink how you might react and move forward in a more mindful direction.
The little book of Hygge: Danish secrets to living happy – Meik Wiking
The Danish people are apparently the happiest in the world, and Hygge is the concept in which you can do it. This book explains how you can embrace this into your daily lifestyle and in turn become a more mindful and happier person | eng | 7af9acae-0419-4a1f-aaa1-cf629bd72140 | https://www.justaveragejen.com/7-books-for-an-introduction-to-mindfulness.html |
Nation Doesn't Understand How Someone As Cool As Kyrsten Sinema Could Fight For Corporate Interests
TUCSON, AZ—Stating it "just didn't add up," the U.S. populace told reporters Wednesday that they didn't understand how someone as cool as Kyrsten Sinema could fight for corporate interests. "She's really someone who has it all—a winning personality, a killer sense of style—so I was really shocked when I found out about all the corporate donations she's raking in," said 34-year-old Anna Monto, a constituent of the senior senator from Arizona, who spoke on behalf of all 330 million Americans in expressing her confusion as to how someone who oozes as much charm and charisma as Sinema could turn out to be just another lapdog for big business. "If she wasn't my senator, she would be my best friend. Anyone who's ever seen her on TV or social media knows she's a total bad ass. I mean, did you see those wigs? It just doesn't make any sense. At least we still have Joe Manchin." At press time, the nation had reached the conclusion that the pharmaceutical and medical industries must just also be really fucking cool. | eng | 969a0d2f-0491-40bb-be86-44f1606c88de | https://bilgipinari.org/nation-doesn-t-understand-how-someone-as-cool-as-kyrste-1847770051/ |
9. Specific Objectives
• At the end of the section, students will be able to:
– Explain the applications of pharmacokinetics to clinical practice.
– Identify the four primary processes of pharmacokinetics.
– Explain mechanisms by which drugs cross plasma membranes.
– Discuss factors affecting drug absorption.
– Discuss how drugs are distributed throughout the body.
– Describe how plasma proteins affect drug distribution.
– Explain the metabolism of drugs and its applications to pharmacotherapy.
– Identify major processes by which drugs are excreted.
– Explain how enterohepatic recirculation affects drug activity.
– Explain how a drug reaches and maintains its therapeutic range in the
plasma.
– Explain the applications of a drug plasma half-life (t1/2) to pharmacotherapy.
Tadesse B. (Ph.D.) 9
General Objective: The aim of this chapter is to introduce the
basic principles of pharmacology
10. Brainstorming?
• How can we define pharmacology?
• How can we define pharmacodynamics?
• How can we define pharmacokinetics?
Tadesse B. (Ph.D.) 10
11. Introduction: Definition of Terminologies
Pharmacology can be defined as:
• The study of drugs and their action on living organisms.
• The study of substances that interact with living systems
through chemical processes (particularly by binding to regulatory
molecules) & alter (activate or inhibit) biologic function or
response
o These substances may be chemicals (drugs) that are
administered to a patient (humans) in order to achieve a
beneficial therapeutic effect
• It can also be defined as a branch of science concerned with the
effects of drugs on living organisms (pharmacodynamics) and
the effects of living organisms with drugs (pharmacokinetics).
• It expresses drug composition & properties, interactions,
toxicology, therapy, and medicinal uses such as application
and antipathogenic capabilities.
Tadesse B. (Ph.D.) 11
12. Introduction: Definition of Terminologies…
• Pharmacogenetics:
– It is the study of genetic influences on responses to drugs.
• Pharmacogenomics:
– It overlaps with pharmacogenetics, describing the use of genetic
information to guide the choice of drug therapy on an individual
basis.
– The underlying assumption is that differences between individuals in
their response to therapeutic drugs can be predicted from their
genetic make-up.
• Pharmacoepidemiology:
– It is the study of drug effects at the population level.
– It is concerned with the variability of drug effects between
individuals in a population and between populations.
• Pharmacoeconomics:
– It is the branch of health economics that aims to quantify in
economic terms the cost & benefit of drugs used therapeutically
Tadesse B. (Ph.D.) 12
13. Introduction: Definition of Terminologies…
• Toxicology:
– It is the branch of pharmacology that deals with the undesirable
effects of chemicals on living systems, from individual cells to
humans to complex ecosystems
• Xenobiotic: (xenos-―stranger‖)
– Any substance/chemical that is foreign to the human body (not
synthesized in the body)
• Receptor:
– The component of a cell or organism that interacts with a drug &
initiates the chain of biochemical events leading to the drug's
observed effects.
• Prodrug:
– It is an ‗inactive' form of a drug that requires metabolic
activation inside the body (bioactivation) in order to release the
‗active' form of the drug.
– Once released in vivo, the active form of the drug will then exert
its pharmacological effect
Tadesse B. (Ph.D.) 13
15. Introduction: Definition of Terminologies…
• Clinical pharmacology:
– Can be defined as the study of drugs in humans.
– Deals with the comparative clinical evaluations of new drug
for developing its therapeutic efficacy and safety
– Its objective is to optimize drug therapy and it is justified in so
far as it is put to practical use
• Clinical pharmacology provides the scientific basis for:
– The general aspects of rational, safe and effective drug therapy
– Drug therapy of individual diseases
– The safe introduction of new medicines.
• It also involves the complex interaction between the patient
and the drug
• It also provides the basis of good prescribing profile that
involves tailoring the drug and dosing regimen to the unique
patient.
– It is the principles behind the prescribing process
Tadesse B. (Ph.D.) 15
16. Introduction: Definition of Terminologies…
• Side Effects:
– Effects which are produced with therapeutic doses of the drug during
the course of treatment, e.g. dryness of mouth with atropine, drowsiness
with antihistamine.
– Usually occurred with drugs that lacks specificity
• Unwanted Effects:
– Produced by therapeutic dose, severe form of which necessitate the
cessation of treatment, e.g. vomiting and diarrhea with PABA
• Toxic Effect:
– The potential harmful effects of a drug in the living human body.
– When the drug level exceeds the therapeutic range
– May be acute or chronic, e.g. chlorpromazine induced cholestatic
jaundice.
• Supersensitivity or Intolerance:
– It is a phenomenon, where some persons began to show responses, when
the dose of the drug is very small in contrast to subjects requiring heavier
doses for the response.
– This people are said to have intolerance or are supersensitive to the
particular drug.
Tadesse B. (Ph.D.) 16
19. Introduction…
• Willingness to learn the principles of pharmacology,
and how to apply them in individual circumstances of
infinite variety is vital to success without harm: to
maximize benefit and minimize risk.
– All of these issues are the concern of clinical pharmacology
• Clinical pharmacology has been termed a bridging
discipline because it combines elements of classical
pharmacology with clinical medicine
Tadesse B. (Ph.D.) 19
20. Introduction…
• Knowledge of clinical pharmacology underpins decisions in
therapeutics, which is concerned with the
– Prevention, suppression or cure of disease
• Pharmacology is the same science whether it investigates animals
or humans.
• The concomitant dangers of drugs (fetal deformities, adverse
reactions, dependence) only add to the need for the systematic
and ethical application of science to drug development,
evaluation, and use
– i.e. clinical pharmacology
• Therapeutic success with drugs is becoming more and more
dependent on the user understanding of both
– Pharmacodynamics and pharmacokinetics
Tadesse B. (Ph.D.) 20
21. Introduction…
• Clinical pharmacology brings together clinical and scientific
practice to support critical & independent appraisal of data
pertaining to drugs and therapeutics, and the rational use of
medicines.
– It started in 1960's due the effect of thalidomide in the early
1960s
– It is needed to address more systematically issues of
• Efficacy, safety and rational use of medicines in
humans becomes crucial along with drug action,
receptors and laboratory experiments
Tadesse B. (Ph.D.) 21
23. Drug-Body Interactions…
• Pharmacodynamics (PDs):
– Refers to the actions of the drug on the human body
(What the drug does to the body)
• Play the major role in deciding whether that class of drugs is
effective therapy for a particular disease or symptom
• Pharmacokinetics (PKs):
– Refers to the actions of the human body on the drug
(What the body does to the drug)
– It is the study of Absorption, Distribution, Metabolism
(Biotransformation) and Excretion (ADME) properties
of the drug with respect to time
• Great significance in the dose selection & administration of a
particular drug for a particular patient
23 Tadesse B. (Ph.D.)
26. Drug-Body Interactions…
• Drugs act in various ways in the body.
– Oral drugs go through three phases:
• The Pharmaceutic Phase,
• The Pharmacokinetic Phase, and
• The Pharmacodynamic Phase
– Liquid and parenteral drugs go through the later
two phases only
26 Tadesse B. (Ph.D.)
28. Drug-Body Interactions…
• The Pharmaceutic Phase of drug action is the dissolution of the
drug.
– Drugs must be in solution to be absorbed.
• Drugs that are liquid or drugs given by injection (parenteral drugs) do
not go through the pharmaceutic phase.
• A tablet or capsule (solid forms of a drug) goes through this phase as it
disintegrates into small particles and dissolves into the body fluids
within the gastrointestinal tract.
• Tablets that are enteric-coated do not disintegrate until reaching the
alkaline environment of the small intestine.
28 Tadesse B. (Ph.D.)
31. Patient Case Scenario 1
• A 60 year lady complained of weakness, lethargy and easy
fatigability.
• Investigation showed that she had iron deficiency anaemia
(Hb 8g/dl).
• She was prescribed capsule, ferrous fumarate 300 mg BID.
She returned after one month with no improvement in
symptoms.
• Her Hb Level was unchanged.
• On enquiry she revealed that she felt epigastric distress after
taking the iron capsules, and had started taking antacid tablets
along with the capsules.
• What could be the possible reason for her failure to respond
to the oral iron medication?
Tadesse B. (Ph.D.) 31
32. Pharmacokinetics Processes
• The goal of drug therapeutics is to:
– Achieve a desired beneficial effect with minimal
adverse effects
• So that it Prevent, cure, or control various disease
states
• To achieve this goal, adequate drug doses must be delivered to
the target tissues so that therapeutic yet non-toxic levels
are obtained.
• Pharmacokinetics examines the movement of a drug over
time through the body.
32 Tadesse B. (Ph.D.)
34. Pharmacokinetics Processes…
• Pharmacological as well as toxicological actions of drugs
are primarily related to the plasma concentrations of drugs.
• Thus, the clinician must recognize that the:
– Speed of onset of drug action,
– Intensity of the drug's effect, and
– Duration of drug action
• Controlled by Four Fundamental Pathways of drug
movement and modification in the body
34 Tadesse B. (Ph.D.)
40. Pharmacokinetics Processes…
• The "standard" dose of a drug is based on trials in healthy volunteers
and patients with average ability to absorb, distribute, and eliminate
the drug
– This dose will not be suitable for every patient.
• Dosage adjustment in individual patients is important due to:
– Physiologic processes (e.g., body size, maturation of organ function in
infants) and
– Pathologic processes (e.g., heart failure, renal failure).
• These processes modify specific pharmacokinetic parameters.
• The two basic pharmacokinetic parameters are:
– Clearance: the measure of the ability of the body to eliminate the drug &
– Volume of distribution: the measure of the apparent space in the body
available to contain the drug
Tadesse B. (Ph.D.) 40
41. Pharmacokinetics Processes…
• Volume of distribution (Vd): relates the amount of drug in the
body to the concentration of drug (C) in blood or plasma:
• Drugs with very high Vd have much higher concentrations in
extravascular tissue than in the vascular compartment, i.e., they
are not homogeneously distributed.
• Drugs that are completely retained within the vascular compartment,
on the other hand, would have a minimum possible Vd equal to
the blood component in which they are distributed
– E.g. 0.04 L/kg body weight or 2.8 L/70 kg for a drug that is restricted
to the plasma compartment
Tadesse B. (Ph.D.) 41
43. Pharmacokinetics Processes…
• Clearance of a drug (CL): is the factor that predicts the rate
of elimination in relation to the drug concentration (C):
– Clinically most important concept in PKs
• Elimination of drug from the body may involve processes
occurring in the kidney, the lung, the liver, and other organs.
• Dividing the rate of elimination at each organ by the conc. of
drug presented to it yields the respective clearance at that organ.
Tadesse B. (Ph.D.) 43
44. Pharmacokinetics Processes…
• Total systemic clearance is the additive clearance from each
organs:
– ―Other‖ tissues of elimination could include the lungs and additional
sites of metabolism, e.g., blood or muscle.
• The kidneys & the liver: The two major sites of drug elimination
– Clearance of unchanged drug in the urine represents renal clearance
– Within the liver, drug elimination occurs via biotransformation of
parent drug to one or more metabolites, or excretion of unchanged
drug into the bile, or both.
Tadesse B. (Ph.D.) 44
45. Pharmacokinetics Processes…
• For most drugs, clearance is constant over the conc. range
encountered in clinical settings, i.e., elimination is not saturable,
and the rate of drug elimination is directly proportional to
conc.
– This is usually referred to as first-order elimination.
• When clearance is first-order, it can be estimated by calculating
the area under the curve (AUC) of the time-conc. profile after
a dose.
– Co-administration of ketoconazole or ritonavir with the hypnotic drug
midazolam increases the midazolam plasma exposure (AUC – area
under the curve) by 15–20 times, a situation which should be avoided
• Clearance is calculated from the dose divided by the AUC.
• Note that this is a convenient form of calculation—not the
definition of clearance
Tadesse B. (Ph.D.) 45
46. Tadesse B. (Ph.D.) 46
Fig. The time course of drug accumulation and elimination.
Solid line: Plasma concentrations reflecting drug accumulation during a constant-rate
infusion of a drug. Fifty percent of the steady-state conc. is reached after one half-
life, 75% after two half-lives, and over 90% after four half-lives.
Dashed line: Plasma concentrations reflecting drug elimination after a constant-rate
infusion of a drug had reached steady state. Fifty percent of the drug is lost after one half-
life, 75% after two half-lives, etc.
Pharmacokinetics Processes…
48. Pharmacokinetics Processes…
• Drug Eliminations can be:
• A. Capacity-Limited Elimination
– For drugs that exhibit capacity-limited elimination (e.g., phenytoin,
ethanol), clearance will vary depending on the conc. of drug
that is achieved
– It is also known as mixed-order, saturable, dose- or conc.-
dependent, nonlinear, and Michaelis-Menten elimination
• B. Flow-Dependent Elimination
– In contrast to capacity-limited drug elimination, some drugs are
cleared very readily by the organ of elimination,
• Most of the drug in the blood perfusing the organ is eliminated on the
first pass of the drug through it.
• The elimination of these drugs will thus depend primarily on the rate of
drug delivery to the organ of elimination.
– Such drugs can be called ―high-extraction‖ drugs since they are
almost completely extracted from the blood by the organ.
Tadesse B. (Ph.D.) 48
49. Pharmacokinetics Processes…
Clinical Estimation of Renal Function
• In routine clinical practice, it is not practical to collect the urine
samples that are needed to measure creatinine clearance directly.
• However, creatinine clearance in adult patients can be estimated
either from a standard nomogram or from equations such as that
proposed by Cockcroft and Gault.
• For men, creatinine clearance (CLCR) can be estimated as follows:
– Provides an estimate of the creatinine formation rate in an individual
patient.
• For women, this estimate should be reduced by 15%.
Tadesse B. (Ph.D.) 49
51. PK process: Half-Life (t1/2)
• Another pharmacokinetic component is the half-life of the
drug.
– Half-life is a measure of the rate at which drugs are
removed from the body
– It is the time required to change the amount of the
drug in the body by half during elimination (or during
a constant infusion)
• The time course of drug in the body will depend on both
the volume of distribution and the clearance:
• Half-life is useful because it indicates the time required to
attain 50% of steady-state or to decay 50% from steady-state
conditions-after a change in the rate of drug administration
51 Tadesse B. (Ph.D.)
𝑡1/2 =
0.693 𝑥 𝑉𝑑
𝐶𝐿
52. PK Principles: Bioavailability (F)
• Bioavailability: the fraction of unchanged drug that reaches the
systemic circulation following administration by any route
• It is expressed as the fraction of administered drug that gains access to
the systemic circulation in a chemically unchanged form.
– For an IV dose of the drug, bioavailability is assumed to be equal to
unity (F=1)
– For a drug administered orally, bioavailability may be <100% for
two main reasons:
• Incomplete extent of absorption across the gut wall
– Only 70% of a dose of digoxin reaches the systemic circulation (due
to lack of absorption from the gut)
– Too hydrophilic (e.g., atenolol) or too lipophilic (e.g., acyclovir) to
be absorbed easily (their low bioavailability is also due to incomplete
absorption)
• First-pass elimination by the liver
52 Tadesse B. (Ph.D.)
53. Pharmacokinetics Processes…
Table: Routes of administration, bioavailability, and general characteristics
Tadesse B. (Ph.D.) 53
Route Bioavailability (%) Characteristics
Intravenous (IV) 100 (by definition) Most rapid onset
Intramuscular (IM) 75 to ≤100
Large volumes often feasible; may
be painful
Subcutaneous (SC) 75 to ≤100
Smaller volumes than IM; may be
painful
Oral (PO) 5 to <100
Most convenient; first-pass effect
may be important
Rectal (PR) 30 to <100 Less first-pass effect than oral
Inhalation 5 to <100 Often very rapid onset
Transdermal 80 to ≤100 Usually very slow absorption
54. PK Principles: Bioavailability (F)…
• Factors that influence bioavailability:
– The extent of absorption may be reduced because of:
• First-pass hepatic metabolism (First-pass effect)
• Chemical instability
oUndergoes destruction at its site of administration
• Nature of the drug formulation
oA drug is incompletely released from its Drug
Formulation
• Physicochemical properties such as insolubility that
prevent complete absorption from its site of administration
54 Tadesse B. (Ph.D.)
56. PK Principles…
• Bioequivalence
– Two related drugs are bioequivalent if they show comparable
bioavailability and similar times to achieve peak blood conc.
– Two related drugs with a significant difference in
bioavailability are said to be bioinequivalent.
• Therapeutic equivalence
– Two similar drugs are therapeutically equivalent if they have
comparable efficacy and safety.
– Note: Clinical effectiveness often depends on both the
maximum serum drug concentrations and on the time
required (after administration) to reach peak conc.
• Therefore, two drugs that are bioequivalent may not be therapeutically
equivalent
56 Tadesse B. (Ph.D.)
57. i. PK Processes: Drug Absorption
• Absorption: the process by which unchanged drug
proceeds from the site of administration to the site of
measurement (blood/circulating body fluids) within the
body
• The rate of absorption determines how soon effects
will begin & depends on the route of administration
• The amount of absorption helps to determine how
intense effects will be
• Drugs can be absorbed from GIT (oral, buccal, sublingual
or rectally), mucous membranes, skin, lungs, muscle or
subcutaneous (SC) tissues
• In order for a drug to be absorbed, it must pass through
cell membranes
57 Tadesse B. (Ph.D.)
59. PK Processes: Drug Absorption…
• The rate and efficiency of drug absorption depend on the
route of administration.
• The route of administration is determined primarily by the
– Properties of the drug (e.g., water or lipid solubility,
ionization, etc.) and
– Therapeutic objectives (e.g., the desirability of a rapid
onset of action or the need for long-term administration
or restriction to a local site).
• There are two major routes of drug administration:
– Enteral (oral & Sublingual) and parenteral.
• The three major parenteral routes are intravascular
(intravenous or intra-arterial), intramuscular, and
subcutaneous.
59 Tadesse B. (Ph.D.)
60. PK Processes: Drug Absorption…
• For IV delivery, for example, drug absorption is complete;
that is, the total dose of drug reaches the systemic
circulation.
• Drug delivery by other routes may result in only partial
absorption and, thus, lower bioavailability.
• Enteric coating of a drug protects it from the acidic
environment; the coating may prevent gastric irritation,
and depending on the formulation, the release of the drug
may be prolonged, producing a sustained-release effect
60 Tadesse B. (Ph.D.)
62. Patient Case Scenario 2
• A 4 year old child is brought to the hospital with the complaint
of fever, cough, difficulty in breathing and chest pain.
• On examination he is found to be dull, but irritable with fast
pulse (118/min), rapid breathing (RR 55/min) and in drawing
of lower chest during inspiration, wheezing, crepitations and
mild dehydration.
• Body temperature is 400C (1040F). The physician makes a
provisional diagnosis of acute pneumonia and orders relevant
haematological as well as bacteriological investigations. He
decides to introduce antibiotic therapy.
• a) In case he selects an antibiotic which can be given orally as
well as by IM or IV injection, which route of admin. will be
most appropriate in this case?
• b) Should the pediatrician administer the antibiotic straight away
or should he wait for the laboratory reports?
Tadesse B. (Ph.D.) 62
64. PK Processes: Drug Absorption…
• Endocytosis and exocytosis:
– This type of drug delivery transports drugs of exceptionally
large size across the cell membrane.
• Endocytosis involves engulfment of a drug molecule by the cell
membrane & transport into the cell by pinching off the drug-filled
vesicle.
– E.g., Vitamin B12 is transported across the gut wall by
endocytosis.
• Exocytosis is the reverse of endocytosis and is used by cells to
secrete many substances by a similar vesicle formation process.
– E.g. Certain neurotransmitters (e.g., norepinephrine) are
stored in membrane-bound vesicles in the nerve terminal &
are released by exocytosis.
64 Tadesse B. (Ph.D.)
67. PK Processes: Drug Absorption…
Effect of pH on drug absorption
• Most drugs are either weak acids or weak bases.
• Acidic drugs (HA) release an H+ causing a charged anion (A-) to
form:
• Weak bases (BH+) can also release an H+. However, the protonated
form of basic drugs is usually charged, and loss of a proton
produces the uncharged base (B):
• A drug passes through membranes more readily if it is uncharged
67
Tadesse B. (Ph.D.)
68. PK Processes: Drug Absorption…
• The higher pH facilitates dissociation;
the lower pH reduces dissociation.
• The uncharged form, HA, equilibrates
across the membrane.
68 Tadesse B. (Ph.D.)
The effective conc. of the permeable form of each drug at its
absorption site is determined by the relative conc. of the
charged & uncharged forms.
o The ratio between the two forms is, in turn, determined by
the pH at the site of absorption & by the strength of the
weak acid or base, which is represented by the pKa
69. PK Processes: Drug Absorption…
Sites of Absorption
• About 80% of drugs are taken orally, therefore, GIT is the main
site of drug absorption
• In addition, drug can be introduced into the systemic circulation
through intramuscular or subcutaneous site skin and respiratory
tract
Tadesse B. (Ph.D.) 69
70. PK Processes: Drug Absorption…
• Factors Affecting Drug Absorption
Route of administration*
Dosage forms
• Particle size
• Disintegration rate and
dissolution rate
• Formulation: type & amount of
additives
– Diluents: Lactose, sucrose,
starch, calcium phosphate
Physicochemical properties of the
drug
• Physical state
• Lipid or water solubility
• Ionization: Weak acid/bases,
organic
Circulation at the site of
absorption
Concentration of the drug
Surface area of absorption site
Blood flow to the absorption
site
Total surface area available for
absorption
Contact time at the absorption
surface
70
Tadesse B. (Ph.D.)
The rate at which a drug undergoes
absorption is influenced by the
physical and chemical properties of
the drug itself and by physiologic
and anatomic factors at the
absorption site.
72. Factors affecting drug absorption…
Sex Differences In Pharmacokinetics: Drug Absorption
• The factors influencing absorption are route-specific and may also be
sex-specific.
• Chemicals or drugs cross body surfaces such as the GIT, respiratory
tract, or skin (different in males and females) to enter the systemic
circulation.
• The absorption rate and extent of a drug are drug-specific.
– Examples of drugs that illustrate sex differences in drug absorption
include rifampicin and IM cephradine.
– Cephradine has a slower rate of IM absorption and lesser bioavailability
in females
• It has been hypothesized that women, by virtue of having greater
subcutaneous lipid content, receive different doses of transdermally
administered drugs.
• Women may also take in less of inhaled aerosol drugs such as
ribavirin and cyclosporine
Tadesse B. (Ph.D.) 72
75. ii) PK Processes: Drug Distribution
• Following absorption or systemic administration into the
bloodstream, a drug distributes into interstitial & intracellular
fluids
• Drug distribution is the process of reversible transfer of a drug
to & from the blood and various tissues of the body (E.g.: fat,
muscle, and brain tissue) and the relative proportions of drug in the
tissues.
• Drug is transported from the site of absorption to the site of action
• This process reflects a number of physiological factors & the
particular physicochemical properties of the individual drug
– Factors that affect the rate of delivery & potential amount of
drug distributed into tissues
• Cardiac output, regional blood flow, tissue volume, &
capillary permeability
75 Tadesse B. (Ph.D.)
76. PK processes: Drug Distribution …
• With exceptions such as the brain, diffusion of drug into the
interstitial fluid occurs rapidly because of the highly permeable
nature of the capillary endothelium
– Thus, tissue distribution is determined by:
• The partitioning of drug b/n blood & the particular
tissue
oLipid solubility & transmembrane pH gradients
are important determinants of such uptake for drugs
that are either weak acids or bases
• The more important determinant of blood-tissue partitioning:
– The relative binding of drug to plasma proteins (PPB) &
tissue macromolecules that limits the concentration of free
drug
Tadesse B. (Ph.D.) 76
78. • Plasma protein binding…
– The fraction of total drug in plasma that is bound is
determined by:
• The drug concentration
• The affinity of binding sites for the drug
• The number of binding sites
– The extent of this binding will influence the drug's
distribution & rate of elimination because only the
unbound drug can:
• Diffuse through capillary beds & cell membrane (↓Vd)
• Produce therapeutic or toxic effect
• Be metabolized or excreted
78
PK processes: Drug Distribution…
Tadesse B. (Ph.D.)
82. PK processes: Drug Distribution…
• Bone:
– The Tetracycline antibiotics (& other divalent
metal-ion chelating agents) & heavy metals may
accumulate in bone by adsorption onto the bone
crystal surface & eventual incorporation into the
crystal lattice
– Bone can become a reservoir for the slow
release of toxic agents such as lead or radium
into the blood
• Their effects thus can persist long after exposure has
ceased
82 Tadesse B. (Ph.D.)
85. PK processes: Drug Distribution…
Volume of distribution (Vd):
It is the measure of the apparent space in the body available to
contain the drug
Relates drug concentration in the plasma to total drug in the
body
Gives rough estimation of overall distribution of a drug
in the body
Vd = Amount of drug in body
Amount of drug in blood
Having high Vd – high distribution
Vd have inverse relationship with PPB
↑PPB ----- ↓VD (mainly found in plasma)
85
Tadesse B. (Ph.D.)
99. iv) PK process: Drug Excretion …
• Excretion is a process of drug transfer from the internal to
the external environment
• Drugs are eliminated from the body either unchanged by the
process of excretion or converted to metabolites
• Excretory organs, the lung excluded, eliminate polar
compounds more efficiently than substances with high lipid
solubility
• Lipid-soluble drugs are not readily eliminated until they are
metabolized to more polar compounds
• Where…?
– Kidney, biliary system, sweat, saliva, milk, lung
99 Tadesse B. (Ph.D.)
106. iv) PK process: Drug Excretion …
Example:
• (1) If we consider that at 0 hour the drug was 1000 mg in the body and it followed 1st
order kinetics and a constant fraction of 10% is filtered(and hence excreted) out by the
kidneys per hour. (A) Calculate the amount at the end of first hour.
• The amount of the drug in the body would be
– 1000 – (1000 × 10/100) = 1000 – 100 = 900 mg.
• (B) Calculate the amount at the end of 2nd, 3rd and 4th hour.
• The amount of drug still remaining in the body would be
– 900 – (900 × 10/100) = 900 – 90 = 810 mg
– 810 – ( 810 × 10/100) = 810 – 81 = 729 mg
– 729 – ( 729 × 10/100) = 729 – 72.9 = 656.1 mg and so forth.
• (2) If we followed of zero order kinetics, the quantity moving was a fixed amount. To
continue with the previous example, let the quantity of the drug in the body was 1000
mg and its excretion followed zero order kinetics and a fixed quantity, i.e. 10 mg is
passed out every hour then at the end of 1st , 2nd , 3rd , and 4th hour the body would
contain.
– 1000 – 10 = 990 mg
– 990 – 10 = 980 mg
– 980 – 10 = 970 mg
– 970 – 10 = 960 mg and so on.
• Unlike the first order kinetics, the amount excreted remains a fixed 10 mg/hr.
Tadesse B. (Ph.D.) 106
111. Drug-body interactions…
• The interactions b/n a drug and the body are conveniently
divided into 2 classes
– Pharmacokinetic Processes
– Pharmacodynamic (PD) processes:
• The actions of the drug on the body
• These properties determine the group in which the drug
is classified & they play the major role in deciding
whether that group is appropriate therapy for a
particular symptom or disease
Tadesse B. (Ph.D.) 111
114. PD processes: Introduction…
Full and Partial Agonists
• Full agonists produce a maximum response
• Partial agonists are incapable of eliciting a maximum
response and less effective than full agonists
Tadesse B. (Ph.D.) 114
Fig. Efficacy and potency of full & partial agonists
In the fig., drug B is a full agonist
& drug A & C are partial agonists
115. PD processes: Introduction…
Tadesse B. (Ph.D.) 115
Duality of Partial Agonists
• In figure displayed below, the lower curve represents effects of a partial
agonists when used alone-its ceiling effect = 50% maximal
• The upper curve shows the effect of ↑ing doses of the partial agonist on the
maximum response (100%) achieved in the presence of or by pretreatment
with a full agonist
• As the partial agonist displaces the full agonist from the receptor, the
response is reduced
– The partial agonist is acting as an antagonist
Fig. Duality of Partial
Agonists
116. PD processes: Introduction…
Pharmacologic Antagonism (Same Receptor)
• Competitive antagonists:
– Cause a parallel shift to the right in D-R
curve for agonists
– Can be reversed by ↑ing the dose of the
agonist drug
– Appear to ↓ the potency of the agonist
• Non-competitive antagonists
– Cause a non-parallel shift to the right
– Can be only partially reversed by ↑ing the
dose of the agonist
– Appear to ↓ the efficacy of the agonist
• Physiologic antagonism (different
receptor)
– Two agonists with opposing action
antagonize each other
– Example: A vasoconstrictor with a
vasodilator
• Chemical antagonism
– Formation of a complex b/n
effector drug & another
compound
– Example: protamine binds to
heparin to reverse its action
• Potentiation
– Causes a parallel shift to the left
to the D-R curve
– Appears to ↑ the potency of the
agonist
Tadesse B. (Ph.D.) 116
118. • Dose-response curves in the presence of
competitive and noncompetitive antagonists.
A) Effect of a noncompetitive antagonist on
the dose-response curve of an agonist. Note
that noncompetitive antagonists decrease the
maximal response achievable with an agonist.
B) Effect of a competitive antagonist on the
dose-response curve of an agonist. Note that
the maximal response achievable with the
agonist is not reduced. Competitive antagonists
simply increase the amount of agonist required
to produce any given intensity of response.
118 Tadesse B. (Ph.D.)
120. PD processes: Introduction…
• Cells may also have different types of receptors, each of
which is specific for a particular ligand
– On the heart, for example, there are β receptors
for NE, & muscarinic receptors for ACH
– These receptors dynamically interact to control
vital functions of the heart
• The magnitude of the response is proportional to the
number of drug–receptor complexes:
Drug + Receptor → Drug-Receptor complex → Biologic effect
120 Tadesse B. (Ph.D.)
123. PD processes …
C. Relation between drug dose & clinical response (Dose-
response relationship)
– The degree of effect produced by a drug is generally a function
of the amount of drug in the site of action (receptor)
• Response ~ concentration (Conc.) of drug at receptor
site
• Conc. of drug at receptor site ~ conc. of drug in plasma
• Conc. of drug in plasma ~ drug administered
So, response ~ drug administered
• Expressed in dose-response curves (DRC)
• DRC is the representation of the observed effect of a drug as a
function of its concentration in the receptor
123 Tadesse B. (Ph.D.)
124. Factors Modifying Drug Action
• An understanding of the reasons for individual variation in response to drugs
is relevant to all who prescribe.
• But pharmacokinetic and pharmacodynamic effects are involved and the
issues fall in two general categories:
– Factors related to patient and drugs:
Fig.: Factors modifying drug action
Tadesse B. (Ph.D.) 124
125. PD processes: Relation between drug dose & clinical response
a) Dose & response in patients
It can be either Graded dose-response relations or Quantal dose-
response curves
1. Graded dose–response relations
• To choose among drugs and to determine appropriate doses
of a drug, the prescriber must know the relative pharmacologic
potency and maximal efficacy of the drugs in relation to the
desired therapeutic effect.
Graded response: the response continuously ↑ as the
administered dose continuously ↑
The response is a graded effect, meaning that the response is
continuous & gradual
More common than quantal dose response, since it involves
single patient/animal
Graph is done by giving different doses of a drug to single
individual & recording response
125 Tadesse B. (Ph.D.)
126. PD Process: Graded dose–response relations
• Two important properties of drugs can be determined by graded
dose-response curves
– Potency and Efficacy (intrinsic activity)
i. Potency:
– It is a measure of the amount of drug necessary to produce an
effect of a given magnitude
– It means how much drug concentration is required to obtain a
given response, usually the fifty percent of the maximal
response.
– It refers to the concentration (EC50) or dose (ED50) of a drug
required to produce 50% of that drug's maximal effect.
• The lower the dose required to elicit given response, the more potent the drug is
– A drug with low ED50 is more potent than a drug with larger
ED50
126 Tadesse B. (Ph.D.)
127. PD Process: Graded dose–response relations
ii. Efficacy (intrinsic activity)
– It is the ability of a drug to illicit a physiologic response
when it interacts with a receptor
– The maximal response given by a drug.
– Efficacy is dependent on the number of drug–receptor
complexes formed & the efficiency of the coupling of
receptor activation to cellular responses
– The maximal response (Emax) or efficacy is more
important than drug potency
– A drug with greater efficacy is more therapeutically
beneficial than one that is more potent
– A drug may have high efficacy but low potency or vice
versa
127 Tadesse B. (Ph.D.)
128. 128
Fig. Graded dose-response curves
Drug B has the greatest efficacy, followed by Drug C, whereas Drug A, despite
being the most potent, has the least efficacy. Drug C is equipotent with Drug B
but has less efficacy
Tadesse B. (Ph.D.)
129. PD Process: Graded dose–response relations
• In selecting one of two drugs to administer to a patient, one must
make that selection based on the relative effectiveness rather
than the relative potency of the two drugs.
• However, pharmacologic potency is going to largely determine
the administered dose of the selected drug.
• In therapeutics, potency of a drug is usually stated in dosage
units with respect to a particular therapeutic end point
• Drug efficacy in a patient may be determined by:
– Mode of interactions of the drug with the receptor (as with
partial agonists)
– Characteristics of the receptor-effector system
– Therapeutic efficacy in a patient also depends on a host of
other factors
129 Tadesse B. (Ph.D.)
130. PD Process: Graded dose–response relations
• In fig (Left), A = B = C in efficacy, A > B > C in potency
• In fig (Right), A = B in efficacy
– A > C > B in potency
• Efficacy is an important quality in a drug.
• Potency is usually not an important quality in a drug
130 Tadesse B. (Ph.D.)
132. PD processes: Relation between drug dose & clinical response…
2. Quantal dose-response curves
– Show the effect of different dose on response among all
(many) individuals taking the drug
– Show individual variation in response for a given dose
– These curves plot the percentage of a population
responding to a specific drug effect versus dose or log
dose
– They permit estimations of the median effective dose, or
effective dose in 50% of a population (ED50)
– Follow none or all for dose administered
• For example, after the administration of a hypnotic drug, a
patient is either asleep or not
– Usually done on animals than humans
132 Tadesse B. (Ph.D.)
134. PD: Quantal dose-response curves
• Effective dose
– The dose that produces the desired effect in 50 % of
all who use the drug is called the median dose
– It is often referred to as the effective dose 50 (ED50)
• Toxic dose
– The dose that produces a toxic effect in 50 % of all
who use the drug is called the toxic dose 50 (TD50)
134 Tadesse B. (Ph.D.)
135. PD: Quantal dose-response curves
• Lethal dose or Toxic dose (LD50 or TD50)
– The dose that results in death in 50 percent of all who use the drug is
called the lethal dose 50 (LD50)
– This is an experimental term that can only be determined in animal
experiments and estimated in humans taking high doses in attempting
suicide
• Therapeutic index (TI): is a measure of drug safety.
– It is the ratio of the dose that produces toxicity to the dose that
produces a clinically desired or effective response in a
population of individuals
– A drug with a higher therapeutic index is safer than one with a
lower therapeutic index
TI of a drug may be defined as the ratio between LD50 & ED50,
i.e.
135 Tadesse B. (Ph.D.)
136. PD: Quantal dose-response curves
• Therapeutic index (TI): Ratio of LD50 to ED50
– Should be > 1
• Drugs with low TI should be used with caution and needs a
periodic monitoring (less safe)
• Drugs with a large TI can be used relatively safely and does not
need close monitoring (highly safe)
136
Fig.: Depiction of ED and LD.
The crosshatched area between the
ED91 (10 mg/kg) and the LD9 (100
mg/kg) gives an estimate of the
margin of safety
Tadesse B. (Ph.D.)
137. 137
Therapeutic window (Therapeutic Range)
Dosage range between the minimum effective therapeutic
concentration (MEC) and the minimum toxic concentration
(MTC)
It is the range of plasma concentrations of a drug that will
elicit the desired response in a population of patients
Tadesse B. (Ph.D.)
138. PD: Peak, Onset, Duration of Action
Tadesse B. (Ph.D.) 138
• Onset of Action:
– Time it takes to reach the minimum effective
concentration
• Peak Action:
– When the drug reaches its highest blood or plasma
concentration
• Duration of Action:
– Length of time a drug has an effect
139. • A) Frequency distribution curves indicating the
ED50 and LD50 for drug X. Because its LD50
is much greater than its ED50, drug X is
relatively safe.
• B) Frequency distribution curves indicating the
ED50 and LD50 for drug Y. Because its LD50 is
very close to its ED50, drug Y is not very
safe. Also note the overlap between the
effective dose curve and the lethal-dose curve.
139 Tadesse B. (Ph.D.)
TI =
𝐿𝐷50
𝐸𝐷50
=
100
10
= 10
TI =
20
10
= 2
140. PD processes: Relation between drug dose & clinical response…
b) Variation in drug responsiveness
– There is a great deal of variability in the responsiveness
to a drug among individuals
• NB: Variation in drug responsiveness has also been
shown in a single individual at different times during
the course of Therapy by the same drug
– Numerous factors affect drug responsiveness including
age, sex, body size, disease state, genetic factors, &
simultaneous administration of other drugs
140 Tadesse B. (Ph.D.)
142. PD processes: Relation between drug dose & clinical response…
• 4 major mechanisms are known to contribute to variation in
drug responsiveness:
i. Alteration in drug concentration at the receptor site:
• Due to PK differences (in drug ADME) among patients,
which leads to variability in the clinical response
ii.Variation in concentration of an endogenous receptor
ligand:
– This particular management leads to a great deal of variability
in responses to drug antagonists & partial agonists
– E.g. the levels of endogenous catecholamines affect the
clinical response to the β-adrenoceptor antagonist propranolol
142 Tadesse B. (Ph.D.)
143. PD processes: Relation b/n drug dose & clinical response…
iii. Alterations in the number or function of receptors:
– An ↑ or ↓in the number of receptor sites or alterations
in the efficiency of the occupancy-response coupling can
cause variability in drug responsiveness
– Alteration in the number of receptor sites is sometimes
caused by other hormones
• E.g. thyroid hormones ↑ both the number of β-adrenoceptors
& cardiac sensitivity to catecholamines
iv. Changes in components of response distal to the receptor:
– Drug response in a patient depends not only on the
drug's ability to bind to the receptor, but also on:
• The functional integrity & efficiency of the biochemical
processes in the cell (occupancy-response coupling) &
• The physiologic regulation by interacting organ systems
143 Tadesse B. (Ph.D.)
144. PD processes: Relation b/n drug dose & clinical response…
• Changes in components of response distal to the receptor…
– Changes in these post-receptor events represent the
most important MZM that causes variation in
responsiveness to drug therapy
– Factors that influence these events include age &
general health of the patient &, most importantly, the
severity & pathophysiologic MZM of the disease
that is being treated
144 Tadesse B. (Ph.D.)
145. PD processes: Relation b/n drug dose & clinical response…
• Changes in components of response distal to the receptor…
– An unsatisfactory therapeutic response is sometimes attributed
to the physiologic compensatory MZMs that respond to &
oppose the effects of a drug (e.g., compensatory
vasoconstriction & fluid retention by the kidney can cause
tolerance to the antihypertensive effects of a vasodilator drug)
– In such cases, additional drugs may be required to treat the
patient
145 Tadesse B. (Ph.D.)
149. Patient Case Scenario 2: Answer
• a) Since the child is seriously ill, a fast and more predictable
action of the antibiotic is needed; a parenteral route of
administration is right.
• Moreover, oral dosing may be difficult in this case as the
child is dull and irritable.
• Entering a vein for IV injection is relatively difficult in
children, particularly in the presence of dehydration.
• Therefore, the antibiotic may be injected IM; however, if
IV line is set up for rehydration, the antibiotic may be
administered through the IV line.
• b) In this case the provisionally selected antibiotic may be
amoxicillin, which should be started as early as possible,
because the child is seriously ill. Waiting for the lab reports to
confirm the diagnosis/ select the definitive antibiotic may
compromise the prognosis.
Tadesse B. (Ph.D.) 149 | eng | 6a871c3c-1c46-4651-a033-b23f6e2ec665 | https://es.slideshare.net/mergawekwaya/chapter-1-msc-pks-pds-ok11pdf |
Where is erionite found?
Asked by: Conner Kuhn
Score: 4.2/5
(23 votes)
Erionite deposits have since been found on every continent, including Antarctica, and in 12 western U.S. states in addition to North Dakota. Some of the earliest deposits in the U.S. were discovered in Rome, Ore., (pdf) which was named after the column-like erionite-bearing rock formations outside of town.
Where do you find erionite?
Erionite is a naturally occurring, microscopic, fibrous mineral. It usually is found in volcanic ash that has been altered by weathering and ground water. Erionite forms brittle, wool-like fibrous masses in the hollows of rock formations.
What is erionite used for?
Therefore, the use of other zeolites may result in exposure to erionite among workers and members of the general population who use the zeolites in various processes and products. The commercial uses of other natural zeolites include pet litter, soil conditioners, animal feed, wastewater treatment, and gas absorbents.
Where can you find crocidolite?
The major commercial source is South Africa, where it occurs in ironstone; it is also found in Australia and Bolivia. Crocidolite is often replaced by quartz, forming the chatoyant semiprecious gems tigereye and hawk's-eye.
What are zeolites in chemistry?
Zeolites are crystalline aluminosilicates belonging to the group of tectosilicate molecular sieves. ... Synthetic zeolites are widely used as catalysts/carriers for many chemical reactions as well as in refining processes. Those amazing materials remain the world largest catalysts produced for industrial applications.
10 Pretty Rocks That Are Deadly
35 related questions found
How many types of zeolites are there?
Types of zeolite
There are nearly 50 different types of zeolites (clinoptilolite, chabazite, phillipsite, mordenite, etc.) with varying physical and chemical properties.
Do zeolites exist naturally?
Zeolites are microporous, aluminosilicate minerals commonly used as commercial adsorbents and catalysts. ... Zeolites occur naturally but are also produced industrially on a large scale. As of December 2018, 253 unique zeolite frameworks have been identified, and over 40 naturally occurring zeolite frameworks are known.
Where can I find zeolites?
Natural zeolites form on volcanic rocks due to the reaction between alkaline and groundwater. They can also be found in shallow marine basins after forming for thousands or millions of years.
Is zeolite safe for humans?
Zeolite has been rated Generally Regarded As Safe (GRAS) for human consumption by the Federal Drug Administration (FDA) and it has been used commercially for water filtration for years. Most studies published show the effectiveness of zeolite to clean up contaminated water from heavy metals and other toxins.
What are natural zeolites?
Natural zeolites are environmentally and economically acceptable hydrated aluminosilicate materials with exceptional ion-exchange and sorption properties. Their effectiveness in different technological processes depends on their physical-chemical properties that are tightly connected to their geological deposits.
What are zeolites made of?
Zeolites are crystalline solids structures made of silicon, aluminum and oxygen that form a framework with cavities and channels inside where cations, water and/or small molecules may reside. They are often also referred to as molecular sieves.
Is zeolite organic?
Organic zeolites are non-silicious solids mimicking physicochemical behavior of zeolites with respect to organic sorbate species. In other words, the shortest definition of "organic zeolites" will be "non-silicious microporous sorbents with hydrophobic porosity".
Where is stibnite most commonly found?
Significant deposits of stibnite have been located in Hunan province, China; on the island of Shikoku, Japan; and in the western United States (Idaho, California, and Nevada).
How is stibnite mined?
Summary: Mining at the Stibnite Gold Project would be accomplished using conventional open pit hard rock mining methods. Mining is planned to deliver 8.05 Mst of ore to the crusher per year (22,050 st/d), with stockpiling by ore type (low antimony sulfide, high antimony sulfide and oxide).
Does scheelite glow?
Scheelite's intense fluorescence under SW UV light and X-rays can help distinguish it from other stones of similar appearance. Although they typically glow an intense bluish white or whitish blue, scheelites that contain some Mo can fluoresce a creamy yellow in SW.
Where are zeolites found in India?
Indian zeolites come from an area of Maharashtra, India called the Deccan Traps, a massive area of ancient lava flows over 6,500 feet thick over 200,000 square miles.
How do you make Zeolite at home?
Preparation of Zeolite Y. Sodium aluminate, sodium hydroxide, and deionized water were placed in a beaker to ensure good mixing on a magnetic stirrer at room temperature. After the solution became transparent, the aqueous colloidal silica was added under agitation for 2 h to yield the sodium aluminate solution.
What are zeolites good for?
Zeolites are minerals that contain mainly aluminum and silicon compounds. They are used as drying agents, in detergents, and in water and air purifiers. Zeolites are also marketed as dietary supplements to treat cancer, diarrhea, autism, herpes, and hangover, and to balance pH and remove heavy metals in the body.
Where is zeolite obtained from?
Natural zeolites are hydrothermal and of mainly volcanic origin. They can occur both in crystallized forms found in igneous and metamorphic rocks, as well as in grains of smaller diameters accumulated in sedimentary rocks [5].
Can zeolite crystals go underwater?
Zeolites contain water in the spaces between the aluminum and silica molecules (tetrahedra). This water moves easily in and out of the crystal. Consequently, any molecule similar in size to water or smaller can pass through the spaces in the zeolite. Larger molecules, however, cannot.
What is alternative to zeolite?
A1 or P. These include transition metals such as Co, Zn, Mn or Fe which substitute for Al, and elements such as Sir Ge or Ti which seem to substitute for P. these materials can be used as catalysts in a similar way to zeolites.
Can you drink zeolite?
Zeolite MED® ultra-fine powder Unless otherwise prescribed by your therapist, you may mix ½ a teaspoon (1g) of Zeolite MED® Ultra-fine Powder into 200 ml of water, 30 minutes before or after eating and drink immediately.
Does zeolite expire?
Answer: Dry powder Zeolite clinoptilolite does not expire if it is stored closed in the jar. You should use only non-metal spoons (wooden, cheramic, glass, plastic). | eng | eda0ce86-b8b5-44ba-b626-29069a164d3b | https://moviecultists.com/where-is-erionite-found |
Gus on the Go: Russian
4+
Learn Russian for Kids
Designed for iPad
Screenshots
Description
Learning Russian has never been so much fun! Join Gus, the friendly owl, as he travels around the world and explore languages from every corner of the globe with Gus on the Go! Featuring adorable animations and fun exercises, your child can learn basic vocabulary concepts with interactive visual and auditory lessons on numbers, colors, shapes and more. Each lesson review unlocks an exciting vocabulary game that reinforces what your child has learned. Now, your child can take on a second language through a fun, multi-sensory journey on any iPad, iPhone or iPod Touch.
Enjoy Gus on the Go: Russian for Kids from toojuice! At toojuice, we are committed to providing entertainment that merges quality learning experiences and fun. Be sure to enjoy more Gus on the Go in more languages including Cantonese, Croatian, English, French, German, Hebrew, Hungarian, Italian, Japanese, Korean, Mandarin (Chinese), Polish, Portuguese, Romanian, Spanish, Taiwanese, Taiwanese Mandarin and Vietnamese!
NOTICE TO PARENTS
This app is kid friendly and does NOT contain ads, in-app purchases, links, tracking or sharing functions.
What's New
Feb 25, 2018
Version 2.9.9
This app has been updated by Apple to display the Apple Watch app icon.
- adds iPhone X support - minor bug fixes
Ratings and Reviews
4.3 out of 5
4 Ratings
4 Ratings
Lovemonsterssunday
, 12/11/2012
Good
Good for elementary learners. Would be nice to be able to move up levels - either in the same app or as an add on.
ncsummersfamily
, 01/29/2018
Perfect for toddlers/kids, fun and adapts to them
My two-year-old daughter absolutely adores this app. It is helping her build foreign language vocabulary extremely quickly. She is able to navigate and use it all on her own due to it's very simple and intuitive interface. In each of four cities, the app is structured into learning exploration sessions which unlock progressively, each followed by a quiz in the form of a fun game. There are four quiz/games in each city. The app is smart in that it remembers which words she needs to work on and gives her more practice on those in the games. She gets little trophies after the quiz/games, and she can see all of her trophies in the little trophy case available in the upper right hand corner on every city. Bronze, silver, and gold levels help the parents to see at a glance how the learning is coming along. This is absolutely worth every penny and so much more, and is the best vocabulary building app for toddlers which I have found. My sincerest thanks to the developer who put so much time and care into creating a wonderful language app for kids in this age range.
_m9316
, 07/25/2020
?
I purchased this app- but everything seems to be locked ???
App Privacy
The developer, toojuice | eng | d67f94f9-d23e-427b-bd32-8bb8524cb6d3 | https://apps.apple.com/us/app/gus-on-the-go-russian/id547244875 |
Part 2: Outline and Notes
A quiet voice whispers informing you you are surrounded by uncountable diverging paths which have the appearance of heartwarming and inviting. You look around, wondering what to do. So you sit for a while to contemplate your situation. Cautiously, you proceed. Your worst fears are realized: there is no way out.
Part 5: Instructions and Amalgamations
A voice speaks warning the journey has found an amazing number of dark tunnels that seem to be mysterious and inviting. You look around, wondering what to do. You realize instantly that it's a trap. Cautiously, you proceed. But you repeatedly find yourself back where you started.
Part 8: Outline and Anecdotes
A voice speaks indicating that you have arrived several dozen entrances that look like scary and obscure. You examine the area, confused. You immediately know what to do. With determination, you abandon your quest. But you repeatedly find yourself back where you started. | eng | 607d6fc5-49fb-40ad-a5d1-cb43895f1cb8 | https://www.emolecules.com/cgi-bin/rene/twisty.cgi?p=3266588139 |
Careers:
Overview
In order to define Theory of Constraints (ToC), it is necessary to define what a constraint is. A constraint is anything that limits the system (organization, enterprise, group, process…) from achieving higher performance relative to its purpose.
A constraint does always exist, otherwise the system would be infinitely successful, constantly achieving higher performance.
A constraint can be part of the system or lying outside of it, e.g. supplies limit the transformation of material, dull market limits the sales, regulation limits operations, etc.
The Theory of Constraints is a "business philosophy" or "management paradigm" that takes into account the existence of constraints, focuses on the one that limits the performance of the whole system and strives to achieve more of its goal. The TOC allows you to plan for and manage constraints in dynamic, uncertain environments and despite scarce resources.
Eliyahu M. Goldratt introduced Theory of Constraints in his 1984 book, The Goal. It is based on the idea that the throughput of a process, value stream, or system is limited only by its constraints or bottlenecks. The methodology is used to identify – and improve or eliminate – the constraint, which restricts or prevents a process from achieving its throughput goal.
ARRELIC EXPERTISE IN THEORY OF CONSTRAINTS | TOC
Theory of Constraints: Three Dimensions
The Theory of Constraints focuses on reducing system bottlenecks as a means to continually improve the performance of the entire system. Rather than viewing the system in terms of discrete processes, TOC addresses the larger systematic picture as a chain or grid of interlinked chains. The performance of the weakest link determines the performance of the whole chain.
TOC considers three dimensions of system performance in the following order:
Throughput (total sales revenues minus the total variable costs for producing a product or service)
Inventory (all the money a company invests in items it sells)
expense (money a company spends transforming inventory into throughput).
Focus on these dimensions can lead a company to abandon traditional management cost accounting while at the same time causing an improvement in competitive price advantage.
Exploit constraint by making small and rapid improvements to the process at constraint location
Subordinate all other steps and activities in the process to focus on the constraint, ensuring they support improvements to the constraint
Elevate constraint in the process to successfully achieve throughput goal by applying more advanced and sustainable improvements; this step is considered as "breaking" the constraint, and may result in identifying a constraint somewhere else in the process
Repeat the continuous improvement cycle for additional or new constraints that limit or prevent the process from achieving throughput goal | eng | 69e06b95-ac49-401a-bf91-2cd8d69da500 | https://arrelic.com/offering/best-practice/theory-of-constraints-toc |
How American Vandal became one of the decade's best (and stupidest) mysteries
Devan Coggan
March 16, 2023, 3:09 PM·13 min read
TV is littered with mystery shows and true-crime rip-offs — but there's never been a mystery quite like American Vandal.This absurdist Netflix gem debuted in 2017, following high schoolers Peter (Tyler Alvarez) and Sam (Griffin Gluck) as they embark on a twisty investigation of high school drama. The two aspiring documentarians approach their puzzle like grizzled investigators, interviewing suspects, piecing together timelines, and reconstructing the scene of the crime. Their mission? To identify the culprit who spray painted dicks on every car in the faculty parking lot.
It's a supremely stupid premise, the kind that could've been a one-note joke stretched too thin. But over the course of its two seasons, American Vandal proved to be something much smarter — and sweeter. The show lovingly lampoons true-crime staples like Serialor Making a Murderer, delivering a puzzle that's both ridiculous and compelling. (In season 2, Peter and Sam returned to tackle a new mystery at a new school, investigating who spiked the cafeteria lemonade with laxatives.) Vandal quickly won over fans and critics alike, and the show even won a coveted Peabody Award, before Netflix pulled the plug.
As part of EW's Whodunnit Week, we sat down with American Vandal creators Dan Perrault and Tony Yacenda, who gamely agreed to answer all our questions about dick graffiti and "heyy" texts. (Since Vandal's cancellation, the pair have also created the deadpan esports mockumentary Playerson Paramount+, which EW called the "best TV surprise" of 2022.)
Here, Perrault and Yacenda open up about Ameriacn Vandal's legacy — and why they're still holding out hope for a potential season 3.
American Vandal Season 1 Tyler Alvarez
Tyler Golden/Netflix Tyler Alvarez in 'American Vandal'
ENTERTAINMENT WEEKLY: Take me back to those first pitch meetings for American Vandal. What do you remember most about the pitching process?
DAN PERRAULT: We had a sort of unorthodox pitch because it was a very unusual show. We had all these visuals we prepared for it. I'm going to try to keep this clean, but we had a particular sort of graffiti that would play a part in the show. We would ask executives to analyze the differences, as if they were the actual documentarians. So, there were elements of it that were almost interactive—
TONY YACENDA: What you're not saying is that there were whiteboard dicks and parking lot dicks. You don't have to censor yourself. [Laughs]
I appreciate the concern, but you definitely have my permission to use the word "dicks." I mean, it's kind of central to the show.
PERRAULT: Okay. [Laughs] So, we had sample graffiti dicks in the actual pitch itself, and after we set up the general premise of what the show was, we would go over the details of the case. In the same way that Sarah Koenig did with Serial, we wanted you to feel like you're a participant. We wanted to make the people listening to our pitch feel the same way because at the end of the day, this was a love letter to those true-crime docs that came before.
YACENDA: I think that was the biggest thing we had going for us in that pitch. Sarah Koenig kind of gave us the template that was peaking when we were pitching the show. She had such an interesting voice when it came to mystery and true-crime content. Before her, it was very much like, "Here's how the justice system and the police f---ed up." I feel like Serial was one of the first times where there was some humility. She comes out and is like, "When I look at [a suspect], he just looks like somebody who's innocent. I know, it's stupid, right?" She was admitting that she was biased. She was telling you: "I'm an unreliable narrator. So, let's figure this out together."
To us, that was the perfect voice to pitch a story about a high school. Dan did a bit of a Serial impression. I would talk about how we would execute the show philosophically, and Dan would talk about it like it was a real crime, and we were just trying to get to the bottom of who drew the dicks.
PERRAULT: I remember some executives asking me questions while I was in character, like, "Are these based off of real people?" I would just have to say, "No, these are real people." I felt like a jerk just shutting them down, especially having essentially no credits before we pitched that show. [Laughs] But it was fun for Tony to be the one who could speak to everything on a directorial level, and I could be in character and give the ridiculous case details on my end.
You talked about how this show was born out of the true-crime boom. What was it about that genre that you found most fun to play around with?
YACENDA: There was a real love for Making a Murderer and The Jinx and Serial. We found ourselves watching it the way they want you to watch it: You're going through all the details, and you have this hubris as you're watching. You're like, "Oh, I'll figure it out. I'm a good judge of character." We wanted to analyze how and why these true-crime documentaries are working on us and getting us to have these conversations about Adnan Syed's cell phone records or Steven Avery's blood samples, as if we have some sort of expertise. We were like, could you do that in a high school? Could you talk about the ball hairs on the whiteboard, or a camp hookup? Did he get to third base? Could you use the engine of a true-crime documentary mystery to kind of Trojan horse a story about high school — and what it's like to be an adolescent in the age of social media?
Mystery storytelling can be tricky, especially over a season-long arc. You have to plot out red herrings and clues without ever tipping your hand to the audience. What was the prep work like in the writers' room, as you were planning all those moments like the camp hookup or the "hey" text with two Ys?
PERRAULT: It's a whole lot of reverse engineering. After we figured out what our crime is and who our main characters are, we would very quickly — within the first week of the writers' room — talk about our final two episodes. What are we building toward? Once we had a foundation of where we begin and where we end, it was a matter of populating that with fun turns.
YACENDA: One of the indictments of the true-crime genre is how much they'll milk things and get into these salacious details that end up going nowhere. But those inconsequential rabbit holes are part of what's fun about a high school story. What I think was a bug in true-crime documentaries is a feature in the comedy that's satirizing it.
It's interesting that you're not parodying a single documentary or true-crime project. You're basically poking fun at the whole genre. What were some of the tropes you had the most fun with?
PERRAULT: I've always been a big fan of the suspicious mid-season character who might know a little more than they let on. And as Tony said, I've always loved the idea of going down a tangentially related rabbit hole, like, "If we can figure out this seemingly unrelated stupid thing, it will pertain to the larger mystery as a whole." I think Nana's party is an example of that, like, "Well, let's figure out who had access to the spray paint can. To do that, we must analyze all these dumb conversations these kids are having and these TikTok videos where people are doing cat-face filters." It's like, how dumb can we make those side stories? But how strong can we make the connection to the main story?
I wanted to ask about Nana's party because that is such a standout episode. Did you really film the whole thing on actual cell phones?
YACENDA: Yeah. Because we see so much on cell phones now, and that's so much of the content we're consuming! There's something about the lens and how an image looks and how the camera moves that is so hard to mimic with a large-sensor camera with interchangeable lenses.
PERRAULT: Not to mention, you would just be creating more work for yourselves to replicate an iPhone video later, when you could just film that way.
One thing that always impressed me about American Vandal is how the high schoolers actually look and sound like high schoolers. That's something that TV usually doesn't get right. How did you work with both the writers and the actors to make it actually feel like high school?
YACENDA: What's interesting is we did a lot of research. We talked to kids, like, "What kind of music are you listening to these days?" We also had this philosophy that we didn't want to use too much current slang. We wanted it to be a little more evergreen, even though kids were realistically using some of this slang. I remember when I was a kid, if I was watching something and the characters are using the exact slang that me and my friends were using, it felt wrong — like it was old guys trying to be young. So, ironically, I think one of the reasons it feels real is because it was a very purposeful decision to keep it a bit more evergreen.
PERRAULT: Another thing is that our cast was obviously very young. We did a lot of improv takes, where we're not coaching them on exactly what to say. So, it would come out the way it would come out of a young person. I think it would be a huge misstep to assume you've got the modern lingo down at any phase past high school, so we certainly didn't try to overstep there.
YACENDA: That's a good point, Dan. The very first thing we shot with Tyler Alvarez, I was like, "I want you to write some of your questions, and I'm going to give you some time with each of our characters to interview them for your documentary." So, he worded his questions a bit more like a 19-year-old would word some of these questions, and our actors are responding to it in real time.
PERRAULT: We really wanted it to feel as authentic as possible, and I think we could have easily overstepped if we pushed them too hard in performance notes. One thing we loved about Sarah Koenig is her incredible passion about the subject and finding the truth. That sort of investment is infectious. Tyler, he himself was so invested in the show and the case. He's always a part of our conversations when we talk about doing a new season or something. He's naturally super interested, and that sort of investment is infectious.
So, you make season 1, and it's a hit. Then, you return for season 2, with fewer dicks, and more poop. What was the process of moving on to a second mystery?
PERRAULT: One thing that lead our brainstorming was: What are major documentary tropes and subgenres of true crime that we haven't hit yet? With season 2, a major one was the sort of "elusive murderer" subgenre, with multiple victims. That led to the idea of: What if there was a serial pooper?
YACENDA: That was the big thing. It's fun when you go a little darker with the second installment, like Empire Strikes Back. We wanted the scope to be bigger.
Melvin Gregg
Scott Patrick Green/Netflix 'American Vandal' season 2
I know a lot of people are still holding out hope for a third season. Do you have an idea of what your ideal season 3 would look like?
YACENDA: Yeah, we know what our third season would be and where the series would go. It's somewhat evergreen, so we could kind of hop back into it whenever the timing felt right, and if we felt like there was an audience that was clamoring for it. But the answer is that we do have a game plan that we're very excited about.
PERRAULT: We've now done three seasons of documentaries if you include Players. There were certain things in Players that were an evolution of things we learned from Vandal. But you always want to bring something new. That's what excites us the most: What can we do that allows the experience to be more immersive and real than the previous one?
That was something I wanted to ask about: American Vandal was your first show. What was the biggest takeaway or learning from making those first two seasons?
YACENDA: We were very fortunate that Netflix was at a time where they could take real risks, and they were very trusting of us. It was also an incredibly inexpensive show for them, so that was the sort of value proposition: Either it works, or it doesn't, but the stakes weren't incredibly high. The great thing is that we were doing something that had never really been done in this way before. Using documentary tools and staying as true to the format as we were staying, it was a little bit easier to have the confidence to stick to our guns and the rules of our world. We knew that even if it doesn't connect, at least it's going to be cohesive and it's going to be unique, at least we're doing something in the comedy space that has never really been done before. That was the safety net, and it gave us a bit more confidence than it would have if we were just making a more traditional, scripted narrative.
PERRAULT: But we really didn't know how people would react to it. It was a really fun ride that people responded. We were making something a little unusual, but I'm glad we stuck to our guns and tried. We also thought Vandal would be a much smaller production web series, and I really credit our friends at CBS, Funny or Die, and 3 Arts who saw it as something bigger.
YACENDA: And for Netflix to take a roll of the dice. It is wild that they gave this project the thumbs up. We're forever grateful. | eng | 3e93ed0b-c164-449a-9856-a6224899bd42 | https://www.yahoo.com/entertainment/american-vandal-became-one-decades-190934143.html |
Should You Ignore Your Snore? A Look at Obstructive Sleep Apnea
Snoring is very common and can often be just a minor nuisance. However, it can sometimes be an indication of a more serious problem, such as sleep apnea. Sleep apnea is a condition in which a person stops breathing for periods of time during sleep. These abnormal pauses in breathing are called "apneas." In obstructive sleep apnea (OSA), the most common type, apneas occur due to a temporary blockage of air movement through the upper airway on the way to the windpipe. The blockages—or obstructions—happen when some structure along the path abnormally collapses against another, requiring increased breathing muscle effort to restore air flow. OSA is common and can be found in both men and women, and in both adults and children.
When to Suspect Obstructive Sleep Apnea
Snoring is usually noted when a person has OSA, although many people without OSA snore as well. If a bed partner reports hearing snoring and noting apneas during a person's sleep, the possibility of OSA may be considered easily. However, the clues are often more subtle; many people with OSA feel poorly rested even after a full night's sleep or are excessively sleepy during the day, dozing off at times when they want to be alert. Other symptoms can include waking up with headaches in the morning or with gasping sensations overnight. If a person has noted any of these issues, a medical provider, such as a physician assistant (PA), can evaluate further and order testing if needed.
The evaluation includes checking for factors that increase the risk that a person may have OSA. Being overweight can increase the odds of having OSA. Development of high blood pressure or difficulty getting blood pressure under control can be associated with OSA as well. Certain findings noted on an examination may also suggest that OSA could be present: having a small lower jaw, a large tongue, large tonsils, a long soft palate (the back part of the roof of the mouth), or a large neck circumference can be associated with OSA.
How to Know for Sure
When signs and symptoms suggest the possibility that a person has OSA, a sleep study is the best next step. This test determines whether a person has OSA and will also indicate the severity of the condition. A sleep study is performed either in a sleep center or in a patient's home. Although testing in a sleep center is more thorough, there are pros and cons for each type, and a PA can help decide which is more appropriate for a certain patient. In both types, monitors are worn during sleep to detect apnea episodes by recording oxygen levels, breathing muscle movements and other measurements. The number of apneas per hour helps to determine whether OSA is mild, moderate or severe.
What are the Treatment Options for Obstructive Sleep Apnea?
Various treatments for OSA are available. The decision of which treatment to select is made jointly by the patient and PA based on the consideration of several factors. These include patient preference and lifestyle, severity level of OSA, sites of obstruction and other health issues. Continuous positive airway pressure (CPAP) devices prevent apneas by directing air pressure into the upper airway using a mask, which prevents collapse when the person inhales. CPAP devices are usually considered the best treatment to try first, as they can provide effective treatment for mild to severe OSA and do not carry the risks of surgery.
Although CPAP is typically well-tolerated, it is not for everyone. Other options include oral appliances, surgical procedures and weight loss. Oral appliances are worn during sleep to keep the jaw and tongue from moving backward and blocking the throat. Unfortunately, they do not fully treat more severe cases of OSA. Surgical treatment options include a myriad of different procedures that address the anatomic site(s) causing the person's obstructions. Weight loss is helpful and is recommended for all patients who are above their ideal weight. With enough weight loss, a person's OSA can decrease in severity and sometimes even resolve. Because weight loss efforts take time, other treatments are used while working toward that goal. All people with sleep apnea should try to avoid things that can worsen OSA, including sleeping flat on the back, consuming alcohol near bedtime, and taking sedating medications.
Why is Treatment Important?
Knowing if OSA is present is important so treatment can be started, as untreated sleep apnea carries risks. If severe OSA is left untreated, a person may have a higher risk of developing serious cardiovascular issues, like high blood pressure, stroke or heart problems. However, even milder cases of OSA benefit greatly from treatment. Because excessive daytime sleepiness—including that from untreated OSA—can increase the risk of accidents, treatment can reduce this risk. Also, treating OSA helps a person feel better by reducing associated symptoms and improving sleep quality, positively impacting daytime performance. For people with OSA, diagnosis and treatment of the condition can be important steps toward living their best life.
Certified PAs are highly qualified, licensed members of health care teams that diagnose and treat patients, prescribe medications, assist in surgery and more! Learn more about Certified PAs and how they can address your health concerns: PAsDoThat.net | eng | 72739033-6508-40f9-aec9-2191f5a0ca63 | https://www.pasdothat.net/sleep-apnea/ |
Why Buy Me?
Stylish detailing pocket and fixed turn back cuffs
Adorable stripe print
Popper fastening | eng | 02283d9f-27b0-40e9-ac1e-6200b3c2fe58 | https://www.mamasandpapas.com/products/stripe-shortie-romper-nb-s94fuq4b0 |
Festiba
The Festival of International Books and Arts (FESTIBA) was created in 2006 to promote an interest and appreciation for reading and early literacy, celebrate and appreciate the arts and humanities, and broaden cultural awareness within the South Texas community. With the theme of Building a Better World, FESTIBA 2021 strives to focus on a bright future by promoting and inspiring education for sustainable development, or the idea that we must teach in a way that empowers students to provide tomorrow's generations with the same opportunities and quality of life that we enjoy today.
CHAPS has participated every year at FESTIBA with lectures, exhibits, and documentary films. Below is our schedule at this years' FESTIBA 2021
CHAPS Lecture Series - FESTIBA 2021
FESTIBA 2021 Lecture Series
MONDAY, FEBRUARY 22
Rio Grande Valley in the Time of Pandemic: Community Responses to COVID-19
This presentation will showcase UTRGV's CHAPS Program's ongoing research. For the tenth year, the CHAPS Program class "Discovering the Rio Grande Valley" has recorded the history of the Rio Grande Valley's Farming families but shifted focus this year to conduct extensive research into all aspects of how the coronavirus has affected our immediate population. Topics include Front-line Medical Workers/First Responders/Underlying Medical Conditions, Medical Migration/Immigration, Education, Community Business/Restaurants, Sports/Entertainment/Religion, and Voting/Poll Workers. This presentation details the findings of this project in anticipation of the publication of the final report later this year. | eng | de859001-5581-4674-8375-4f901338855f | https://www.utrgv.edu/chaps/community-engagement/festiba/index.htm |
Vega 100mg (Sildenafil Citrate)
Vega 100mg is a medication that contains the active ingredient Sildenafil Citrate. It is primarily used to treat erectile dysfunction (ED), a condition in which men have difficulty achieving or maintaining an erection sufficient for sexual activity. Sildenafil Citrate is a phosphodiesterase type 5 (PDE5) inhibitor, which means it works by relaxing the blood vessels in the penis, allowing increased blood flow and facilitating the achievement and maintenance of an erection when sexually aroused. | eng | ef158f91-c623-46dd-bc31-07fb27e2f8ca | https://www.medixpills.com/vega-100-mg/attachment/vega-100mg-copy/ |
Common Chihuahua Health and Mobility Problems
Whether you have a Smooth-Coat or Long-haired Chihuahua you know that your dog might by tiny in size, but their feisty temperament more than makes up for their diminutive build. Understanding your dog's health risks and potential for mobility issues can help you better prepare to care for your chihuahua in their senior years.
Five potential chihuahua health concerns include: knee problems, spinal injury, hydrocephalus, obesity, and vision loss. Read on to learn more about each one of these health issues and how they can impact your tiny pup!
Luxating Patella
Knee problems and patellar luxations are common among Chihuahuas. A luxating patella is when a Chihuahua's kneecap dislocates and slips out of place. Most patellar luxations are fairly mild and only impact one leg.
A dog with a slipped kneecap will point their leg backwards or to the side and stretch until the kneecap repositions itself. As a dog with knee problems gets older they are more likely to develop arthritis in the joint and may struggle with their mobility as a senior. More severe cases of patellar luxation may require surgical repair to keep the knee in place.
Chihuahua and the Risk of Spinal Injury
Chihuahuas are more likely to have instability in their neck, specifically in their first two vertebrae. This type of instability in the cervical spine causes the dog's spinal cord to compress leading to neck pain and mobility problems.
Like other toy breeds, due to their small size chihuahuas are at high risk for spinal trauma and injury. Chihuahuas are unaware of how small they really are and they love to be with their owners and playing with other pets. This puts that at risk for an unintentional back injury, nerve damage, and in the most severe cases paralysis.
Hydrocephalus
The chihuahua breed is genetically predisposed to hydrocephalus, there are no apparent genetic markers that would flag a chihuahua mother as a carrier right now. A chihuahua born with hydrocephalus will appear normal at birth, although they are often smaller than the rest of their litter. The first signs of hydrocephalus will appear when the chihuahua is a few weeks older.
A dog with hydrocephalus experiences a buildup of spinal fluid in the brain that can alter a dog's appearance and behavior. Dogs with hydrocephalus appear to have a larger than normal, dome-shaped head and may show signs of brain damage. Chihuahua puppies with hydrocephalus are prone to seizures, "manic" walking, blindness, and often press their heads against a wall. Symptoms can range in severity from mild to very extreme. Surgical repair is possible to help reduce the fluid in the brain and can help relieve some of the symptoms of hydrocephalus although treatment can be difficult with varying results.
How to Help a Chihuahua Walk
A dog wheelchair is a simple way to help your Chihuahua walk again. Because of their tiny size and small build, a chihuahua's wheelchairs needs to be lightweight. Your CHI doesn't have to be paralyzed to us a wheelchair. Dog wheelchairs are often used in rehabilitation for knee injuries, spinal problems, loss of leg strength, and joint issues. Although it's easy to carry around this tiny breed, it's important that your chihuahua walk on their own too. Continued exercise will keep their legs healthy, help prevent further muscle loss, and help your dog maintain the leg strength they have.
Chihuahua Obesity and It's Impact on Their Health
Due to the Chihuahua's small stature they are considered high risk of obesity. Even a pound or two over their ideal weight can place additional stress and pressure on a Chihuahua's joints which can lead to joint problems, arthritis, and difficulty walking. Additionally, as they become a senior the Chihuahua has a tendency to become lethargic and less apt to exercise which can lead to rapid weight gain. A gentle exercise program and an active lifestyle can help keep your dog's weight down.
Chihuahua Eyesight and Vision Problems
Chihuahuas are prone to loss of vision due to progressive retinal atrophy or PRA. A Chihuahua with PRA will have a difficult time seeing in the dark or low lighting. Night blindness is often the earliest sign of progressive retinal atrophy in dogs. As the condition progresses the dog's vision loss will worsen and lead to eventual blindness.
PRA isn't the only eye condition that Chihuahua parents have to worry about. The Chihuahua is also genetically prone to developing Cataracts, Glaucoma, and dry eye from a condition called keratoconjunctivitis sicca.
Did we answer all your questions on "Chihuahua | eng | 1114b682-0357-47ac-bf60-6aea3d29cd6a | https://www.handicappedpets.com/blog/chihuahua-health-and-mobility-problems/ |
Induction Motors
Product Details (910111213) :
A "Face Mount Induction Motor" typically refers to an induction motor that is designed to be mounted directly onto a flat surface, such as a frame or a machine structure, using its face or flange. The term "face mount" indicates the motor's mounting configuration rather than its internal workings. Induction motors with a face mount configuration are commonly used in various industrial and commercial applications.
Here are some key points about face mount induction motors :
Mounting Configuration :
In a face mount induction motor, the motor's flange or face is designed to be bolted or attached directly onto a flat surface, usually using mounting holes provided in the motor casing.
The face mount configuration is used to secure the motor in place and ensure proper alignment with the driven equipment.
Applications :
Face mount induction motors are used in a wide range of applications, including pumps, fans, conveyors, mixers, industrial machinery, and other equipment where the motor needs to be securely attached to a structure or frame.
Design Variations :
Face mount induction motors can come in various designs, such as foot-mounted (also known as flange-mounted) or footless (c-face) designs. Foot-mounted motors have feet that extend from the motor housing, allowing them to be directly bolted to a surface. Footless or c-face motors lack feet and have a flange that mounts directly onto a surface.
Shaft Orientation 0:
The orientation of the motor's output shaft can vary based on the design. Some face mount motors have a shaft that extends from the motor's front face (shaft facing outward), while others have a shaft that extends from the motor's rear (shaft facing inward).
Alignment Considerations :
Proper alignment is crucial when installing face mount induction motors to ensure that the motor's shaft aligns accurately with the driven equipment's shaft. Misalignment can lead to increased wear, vibration, and reduced efficiency.
Maintenance and Accessibility :
Face mount motors are designed for ease of maintenance since they can be directly accessed when mounted on a surface. This facilitates inspections, repairs, and replacements.
Energy Efficiency :
Like other induction motors, face mount induction motors can be designed to meet energy efficiency standards, contributing to overall energy savings in the application.
When choosing a face mount induction motor for an application, considerations should be made regarding power requirements, speed, torque, efficiency, and the mounting surface's compatibility. Proper installation and alignment are essential to ensure the motor's longevity and optimal performance within the system.
Product Details (14) :
A "Flange Mount Induction Motor" is a type of induction motor that features a flange on its housing, which allows it to be securely mounted onto a flat surface, such as a frame or a machine structure. The flange provides the necessary attachment points for bolting the motor to the surface, ensuring proper alignment and stability. Flange mount induction motors are commonly used in various industrial and commercial applications.
Here are some key characteristics and considerations related to flange mount induction motors:
Flange Mounting :
The flange on the motor's housing contains holes or slots that are used for attaching the motor to a flat surface. These holes are strategically positioned to ensure a secure and stable connection
Applications :
Flange mount induction motors are used in a wide range of applications, including pumps, fans, conveyors, mixers, machine tools, industrial machinery, and other equipment where the motor needs to be securely attached to a structure or frame
Design Variations:
Flange mount motors can have different flange sizes and configurations based on the specific requirements of the application. The flange size and bolt hole pattern may vary to accommodate different mounting needs
Alignment Considerations :
Proper alignment is crucial when installing flange mount induction motors to ensure that the motor's shaft aligns accurately with the driven equipment's shaft. Misalignment can lead to increased wear, vibration, and reduced efficiency.
Maintenance and Accessibility :
Flange mount induction motors are designed for easy maintenance since they can be accessed directly when mounted on a surface. This facilitates inspections, repairs, and replacements.
Energy Efficiency :
Similar to other types of induction motors, flange mount induction motors can be designed to meet energy efficiency standards, contributing to overall energy savings in the application.
Installation:
Proper installation involves securely attaching the motor to the mounting surface using the provided bolt holes. Care should be taken to ensure that the motor is aligned correctly and that the mounting surface is strong enough to support the motor's weight and the loads it will experience during operation.
System Integration :
Flange mount induction motors can be integrated into various industrial automation systems, controlled using variable frequency drives (VFDs) for speed control, and incorporated into machinery where precise movement and operation are required.
Choosing the right flange mount induction motor for an application involves considering factors such as power requirements, speed, torque, efficiency, and the compatibility of the motor's flange design with the mounting surface. Proper installation and alignment are essential for maximizing the motor's performance and lifespan.
Product Details (138) :
A "Foot Mount Induction Motor" is a type of induction motor designed with feet or flanges on its housing that allow it to be securely mounted onto a flat surface, such as a base or a machine frame. The feet provide the necessary attachment points for bolting the motor to the surface, ensuring proper alignment and stability. Foot mount induction motors are commonly used in various industrial and commercial applications.
Foot mount induction motors have protruding feet on their housing that contain holes or slots. These feet are used to securely attach the motor to a base or surface by bolting them down.
Applications :
Foot mount induction motors are widely used in applications where stable mounting and alignment are crucial, such as pumps, fans, conveyors, mixers, industrial machinery, and other equipment.
Design Variations :
The design of the feet can vary based on the specific motor model and application. Some motors have two feet, while others have four. The configuration of the feet may differ to accommodate different mounting needs.
Alignment Considerations :
Proper alignment is essential when installing foot mount induction motors to ensure that the motor's shaft aligns accurately with the driven equipment's shaft. Misalignment can lead to increased wear, vibration, and reduced efficiency.
Maintenance and Accessibility :
Foot mount induction motors are designed for easy maintenance, as they can be accessed directly when mounted on a surface. This facilitates inspections, repairs, and replacements
Energy Efficiency :
Foot mount induction motors can be designed to meet energy efficiency standards, contributing to overall energy savings in the application.
Installation :
Proper installation involves securely attaching the motor to the mounting surface using the provided feet and holes. Care should be taken to ensure that the motor is aligned correctly and that the mounting surface is strong enough to support the motor's weight and the loads it will experience during operation.
System Integration :
Foot mount induction motors can be integrated into various industrial automation systems, controlled using variable frequency drives (VFDs) for speed control, and incorporated into machinery where precise movement and operation are required.
Selecting the appropriate foot mount induction motor involves considering factors such as power requirements, speed, torque, efficiency, and the compatibility of the motor's foot design with the mounting surface. Proper installation and alignment are essential for maximizing the motor's performance and lifespan.
Product Details (139) :
A "Foot cum Flange Mount Induction Motor" is a type of induction motor that combines features of both foot-mounted and flange-mounted designs. This type of motor is designed with both feet and a flange on its housing, providing multiple options for secure mounting onto different types of surfaces. The combination of mounting options allows for flexibility in installation and integration into various industrial and commercial applications.
Similar to foot mount and flange mount motors, foot cum flange mount induction motors are designed for easy maintenance, as they can be accessed directly when mounted on a surface.
Energy Efficiency :
Foot cum flange mount induction motors can be designed to meet energy efficiency standards, contributing to overall energy savings in the application.
Installation :
The installation process involves selecting the appropriate mounting method (foot or flange) based on the specific requirements of the application. Proper alignment and secure attachment are essential for optimal performance and longevity.
System Integration :
These motors can be integrated into various industrial automation systems, controlled using variable frequency drives (VFDs) for speed control, and incorporated into machinery requiring precise movement and operation.
When choosing a foot cum flange mount induction motor, factors such as power requirements, speed, torque, efficiency, and the compatibility of the motor's design with the mounting surface(s) should be considered. Proper installation and alignment are key to ensuring the motor's performance and reliability in the intended application. | eng | aaf62d19-e5b7-4f68-a60d-15e3242bd427 | https://www.stallionprivatelimited.com/products/three-phase-induction-motor |
JP/Are raw vegetables much healthier?
Is it true that it's healthier to eat vegetables raw instead
of cooking them? Thanks.
-- Ray
Dear Ray,
You have touched on a very interesting question that gives me
the opportunity to dispel yet another myth about food and
nutrition.
I have always been a proponent of eating plenty of fruits and
vegetables as they are excellent sources of vitamins, minerals,
fire?, and antioxidants, which have been linked to numerous
health benefits. Therefore, it makes sense that when we eat our
fruits and vegetables, we make sure we prepare them in a way that
allows our bodies to take advantage of these substances to their
fullest.
There is an entire movement devoted to eating only raw foods
and in fact, in many large cities, restaurants that serve only
raw foods have become trendy.
This love for raw food has extended well beyond just fruits
and vegetables to include meats and starchy foods. The latter
trend has developed due to studies that indicate that cooking
grains and starchy foods such as potatoes at high temperatures --
particularly baking or frying in high fat -- can create possible
carcinogens, or cancer-causing compounds called acrylamides.
However, the research on whether or not acrylamide is actually
linked to disease in humans is still in its early stages. The
wise approach would be to avoid foods that are high in fat or
fried -- something I recommend for many other reasons as well
including preventing heart disease and obesity.
A trend towards eating raw meat and fish, completely separate
from cuisines such as sashimi, sushi, tartare or carpaccio; has
developed due to studies indicating that grilling, frying, or
broiling high-protein items such as meat or fish can cause other
potentially dangerous substances called heterocyclic amines.
However, there are sensible ways to lessen or prevent the
formation of these compounds. One of the main culprits of
heterocyclic amine formation is fat dripping onto the hot surface
of the grill or stove. Choosing lean cuts of meat and trimming
off the visible fat are easy ways to avoid this problem.
Marinating meat and fish in an acidic substance such as lemon
or any kind of fruit juice before cooking helps prevent up to 85
percent formation of heterocyclic amines. The key factor is the
antioxidant action of vitamin C in the marinade.
It should also be pointed out that only skilled, trained chefs
should prepare and serve raw meat and only high quality meat and
fish that has been properly handled at all levels of distribution
should be used. Persons who are at risk such as children, the
elderly, pregnant women or anyone with weakened immune systems
should avoid raw meat and fish.
In short, eating uncooked meat and seafood can increase your
risk of food-borne illness, commonly known as food poisoning.
So what about fruits and vegetables?
Proponents of the raw food movement claim that cooking robs
fruits and vegetables of their nutritional value. This is true up
to a certain point. Some vitamins and minerals are sensitive to
high temperatures and can be destroyed with cooking. These
include several of the B vitamins like folate and also vitamin C.
Cooking in water further compounds the problem since even more
of the vitamins and minerals as well as fiber are lost when they
are leached out into the water.
Finally, proponents of raw food also claim cooking destroys
many of the natural enzymes found in food which help with
digestion and absorption of nutrients. However, even if we eat
raw foods, most of those enzymes are killed as soon as they reach
the stomach due to the highly acidic environment necessary for
digestion to occur.
Losses from boiling can be addressed by using alternate
cooking methods such as stir-frying or steaming and by avoiding
over-cooking. Vegetables should only be stir-fried or steamed
until they are still crisp and bright-colored.
Loss of nutrients due to heat can only be avoided up to a
certain point, but when proper cooking methods are used, these
losses usually only amount to about 15-30 percent.
Ironically, there are also some benefits to be derived from
cooking your vegetables since cooking weakens cell walls and
allows the body to extract more of the nutrients that remain
after cooking. Cooking also makes for more dense servings since
vegetables tend to be high in water content. Half a cup of cooked
spinach weighs three times as much as a half cup of raw spinach.
Even accounting for losses during cooking, the half-cup of
cooked spinach contains three times as much calcium, iron, and
vitamin A. It is also significantly higher in fiber, folate, and
vitamin C.
Properly cleaning raw produce to ensure it's safe to eat is a
lengthy process which may be difficult to control outside of your
home, so one other benefit of eating cooked vegetables is that
food safety concerns can be alleviated.
Eating raw food does not necessarily ensure that nutrients
won't be lost. In fact, any kind of preparation process, not just
cooking, results in some loss of nutrients. Peeling exposes
produce to oxygen and causes the break-down of vitamins C and E
for example. Chopping and blending may lead to further losses
however just as with cooking, these losses are compensated as
nutrients become more available when cell walls break down.
Juices still contain some nutrients, but many of the nutrients
as well as the fiber are lost when peels and pulp are discarded
in the juicing process.
In short, make sure you eat plenty of fruits and vegetables
and use a variety of methods to enjoy them: cooked, raw or
juiced. Just remember to keep your fruits and vegetables healthy
by using proper cooking methods, and accompanying them with
healthy dressings, dips, and sauces! | eng | efd1cd23-4962-40f2-8164-07e24ecf6a84 | https://jawawa.id/newsitem/are-raw-vegetables-much-healthier-1447893297 |
Why Does a Garage Door Rust and How to Prevent it
Table of Contents
| eng | 4ea3145f-0dc3-4b48-ad03-ba5e63bd54c3 | https://garagedoordoctor.biz/2022/08/28/why-does-a-garage-door-rust-and-how-to-prevent-it/ |
Magnetic Separators McMaster-Carr
Magnetic Separators 911 Metallurgist
网页Magnetic separators that utilized permanent ferrite magnets, such as drum-type separators, generated relatively low magnetic field strengths. These separators worked well collecting ferrous material but were ineffective on
Magnetic Separator Components Selection Guide: Types, Features
Magnetic separation Wikipedia
网页Magnetic separation is the process of separating components of mixtures by using a magnet to attract magnetic substances. [1] The process that is used for magnetic separation separates non-magnetic substances from those which are magnetic.Development of a high-gradient magnetic separator for
网页2023年5月1日Modern high-gradient magnetic separation (HGMS) initially originated from a magnetic filter patented in 1937 by Frantz [ 1 ], in which the ferromagnetic matrix of fine wires or rods was first introduced into a uniform magnetic field to increase the magnetic field gradient by several orders of magnitude [ 2 ].A Guide to Magnetic Separation Eclipse Magnetics
网页In a magnetic separator the magnet is contained in tube or cover. When specifying the magnetic strength, it is important to check with the manufacturer that the Gauss reading is taken on the outside of the tubenetic Separator an overview ScienceDirect Topics
). Test tube magnetic separators enable | eng | aba185c0-50a8-49fe-b2b6-b487e05798d3 | https://www.dr-duclot-chirurgien-dentiste.fr/talc/1684467276-Magnetic-separator-specialty/2724/ |
No. But I will vote for MORE provincial autonomy. More autonomy means less trudeau, Toronto, and quebec in our lives. Just imagine how Alberta would flourish and prosper without their boots on our neck.
No. But I will vote for MORE provincial autonomy. More autonomy means less trudeau, Toronto, and quebec in our lives. Just imagine how Alberta would flourish and prosper without their boots on our neck.
The liberals will never allow that to happen, it would interfere with the UN/WEF agendaIf it was Alberta USA, We'd have a pipeline to the gulf and it would be Texas North. Even though Biden campaigned against it in 2020, someone who is actually running the USA has seen a benefit to the production in Alaska. Biden just says what he's told to say.
No. But I will vote for MORE provincial autonomy. More autonomy means less trudeau, Toronto, and quebec in our lives. Just imagine how Alberta would flourish and prosper without their boots on our neckAre there and good wholesome ones? Just need one two will not work
Since we're all spitballing here, if Alberta is such a problem, ugly cousin to Canada how about Ottawa sells Alberta to the USA for a few trillion dollars. The USA grew their dominion by buying Louisiana and Alaska. Why not buy Alberta.
Seems to me it would be a win, win, win. Ottawa get rid of us as we seem to only be a liability to them. Alberta wins and we no longer have to worry about Ottawa coming down on us. The USA wins as they get more energy to develop closer to the lower 48 than AlaskaI agree 100% separation is our only chance! Joining the us would just devastate our wildlife... there's already to many americans coming here every hunting season!
BTW I got a C+ for being "unpatriotic" according to the people who ran things in Ontario school. At the time I wanted to sell all of Canada for 1 million dollars to each man woman and child and with the resources in Canada the USA would have jumped at it. Guess the short crew cut chinese teacher thought we were all going to remain hippies. Even then I think he was a socialist leaning teacher also taught math and told me my mind was like a sieve all the good stuff went through and the garbage stayed. Still remember his name and often wondered if he had any idea I became an accountant despite his efforts. He didn't show up for the reunion 25 years later in 1996 and no one there could say what happened to him.
At least in the US a president can only serve 2 terms. The way things are in Canada and the amount of gullible morons that still support the Turd, he could be here much longer.
This is true but I am just looking at present day and can't predict there future president
In a lot of ways I would prefer separation over joining the US because I don't know how much of an improvement the US would be. But it's not an option presently so there is no terms of negotiation to even consider
I think as part of the U.S.A. you could probably say goodbye to that little gift we call crown land. Logging companies and Oil and gas would no longer lease but would own . Probably some publicWhile that is true. We would have two elected senators just like all the other states where some influence could be had. Unlike the stacked, appointed senate we have now think as part of the U.S.A. you could probably say goodbye to that little gift we call crown land. Logging companies and Oil and gas would no longer lease but would own . Probably some publicI highly doubt that. I'm sure some would but not to the level you predict. Between national forest, national grassland bureau of land management wilderness areas and national parks not to include whatever is preserved on the state level. An example 2 sections out of every township in Montana is held in public trust as dnrc land. Doubt it will ever happen so no point stressing over what if .__________________
"The forest was shrinking but the trees kept voting for the axe as its handle was made of wood and they thought it was one of them." - Aesop
"We can easily forgive a child who is afraid of the dark; the real tragedy of life is when men are afraid of the light." - PlatoIsn't that odd, that so many immigrants vote for the type of government most similar to the one that they escaped from.118 years ago eastern Canada divided Alberta and sask to stop them from having any political clout that could threaten the pool of power in the east. This country was created by enslaving the west to the east's whims. Confederation has never worked, nor will it ever. You can hold on to the romantic idea that Canada was great; the fact is in the west we have always been nothing more than serf to the ruling laurentian elite. Personally, I'd rather strike out on my own, than be under the thumb of the political class. All in the name of a flag no less. Just how united has Canada ever been? The provinces have had disdain for each other longer than I've been alive. | eng | a3110ac4-5fa4-40d0-9942-561532407ca0 | http://www.outdoorsmenforum.ca/showthread.php?s=16ef00c75c0758eeb8a0d892f0eca454&t=419727 |
Al Marder: A Life of Conviction
Alfred Marder (b. 1922), life-long resident of New Haven, World War II veteran, and University of Connecticut graduate, came to adulthood during the turbulent times of the Great Depression. He joined the Communist party as a teen in 1938, served as the chairman of the Connecticut Young Communist League, and was one of the organizers of the campaign for the first evening college in the state. As a Communist party organizer in 1952 in New Haven during the Cold War, he helped to organize an unsuccessful campaign to allow African Americans to work as bus drivers. He was one of 215 people arrested in 1954 under the Smith Act (which from 1949 to 1954 allowed for federal prosecutions of Communist party leaders accused of conspiring to overthrow the government). Marder was subject to McCarthy-era Federal Bureau of Investigation surveillance and underwent a lengthy trial in New Haven that was covered by the Associated Press and reported across the country. His defense attorney was Catherine Roraback, a celebrated civil rights attorney. Today, at age 93, Marder continues to be involved with his community, serving as the president of the Amistad Committee, Inc., chairman of the Connecticut Freedom Trail, and president of the U.S. Peace Council. I sat down with Al to talk about what it was like to be a Communist organizer in New Haven in the 1950s.
MD: Al, you grew up in New Haven during the Great Depression. What was that like?
AM: My parents were Jewish immigrants from the Ukraine. They owned a small grocery store during the 1930s on Oak Street. We worked and ate in the store. It wasn't far from the railroad yards and on a daily basis men would come into the store and ask for food. I sometimes gave them food, but my father would say, "We cannot afford to feed the whole world." Life for my parents was hard. The sheriff would come into the store and demand money out of the register to pay creditors.
MD: What were the major influences on you when you were growing up?
AM: I went to James Hillhouse High School in New Haven with many children of immigrants with socialist ideas. We were deeply concerned about the rise of fascism in Spain and knew men that volunteered for the Abraham Lincoln Brigade [Americans who fought as volunteers in the Spanish Civil War, 1936 – 1939]. Discussions about labor rights, unionization, racial equality, and the American economy were common. The Hillhouse Debate Team topic one year was "Is the U.S. Post Office Socialist?" People came from families that were hungry. There was no denying that working people were suffering.
MD: How did you become politically active?
AM: I became active in high school organizing New Haven workers in unions—electrical, steel, and clothing workers. Union organizers were young people, too, and they needed volunteers, so I helped to distribute flyers. We lived on Davenport Avenue in a two-family house. I slept on a porch so it was easy for me to get dressed and sneak out of the house to go hand out flyers before the 7 a.m. work shift at Sargent's and New Haven Clock companies. The organizer would pick me up—I'd go out the window. I would come home, go back to bed, and pretend to wake up when my mother called me. I discovered much later that my parents knew what I was doing but decided not to stop me.
MD: What happened after high school?
AM: I stayed out [of school]one year and did youth work. I was the chairman of the New Haven Conference of Youth and helped to organize the campaign for the first evening college in Connecticut at what's now Southern Connecticut State University. There were no college courses available for working kids. We recruited students for the night college—everyone involved in the campaign had to enroll. After one semester I transferred to UCONN. I was drafted into the U.S. Army in 1942 and for almost two years, the army wouldn't send me overseas because of my political views as a Communist.
MD: What about the Cold War period of the 1950s? I found your name in more than 50 newspaper stories from across the country.
AM: I become a printer to support my family and was a Communist party (CP) organizer. It was a violent period. My phone was tapped, my neighbors were interviewed by the FBI, my mail opened. This was the McCarthy period. Conditions became such that the CP couldn't afford staff. In 1952, we thought communists would be rounded up and arrested, so I went to New York City under an assumed name, "Ken Green," and got a printing job. I was arrested on May 29, 1954 at my home in New Haven as a communist leader and indicted by a federal jury for violation of the Smith Act. There were seven of us arrested [later an eighth was added], and we plead[ed]innocent. We couldn't get legal representation. No one wanted to be associated with communists. So I sent a mimeographed letter to hundreds of Connecticut attorneys asking for representation. We maintained that being a member of the CP was not illegal. Six of the defendants were convicted and I was acquitted, but their sentences [were]later thrown out by a federal appeals court. [They] found no direct evidence that showed that the defendants advocated the violent overthrow of the government. [Still,] this frightened people and decimated the CP.
MD: And since the 1950s?
AM: In the 1970s, I worked against the [Vietnam] War; 1980s on the anti-nukes movement, the first world conference for peace in 1986; the founding of the Amistad Committee in 1988. I continue to be involved in the struggle for workers' rights, racial equality, and peace.
Mary M. Donohue is a frequent contributor to and the assistant publisher of Connecticut Explored. She thanks Al Marder for granting this interview, conducted in August 2015.
Hear longtime community activist Al Marder talk about his early days in New Haven as a labor organizer and communist party member and his arrest at his home under the Smith Act in 1954. Judge Andrew Roraback will share insights about Marder's defense by Roraback's cousin, the celebrated Catherine Roraback. newhavenmuseum.org
READ
For more information about the labor movements including the Communist Party in the 1930s, read Hartford Labor Militants Fight the Spanish Civil War Connecticut Explored, Summer 2004, ctexplored.org/hartford-labor-militants-fight-the-spanish-civil-war/
RESEARCH
To access more than 50 newspaper articles pertaining to the New Haven Smith Trials and Alfred Marder visit Ancestry.com and search for Alfred Marder Educational | eng | 4e911e4c-0338-4150-8ee9-89b7d10c6580 | https://www.ctexplored.org/al-marder-a-life-of-conviction/ |
Airing from 1964-67, Breezly andamp; Sneezly was a series that followed Breezly's ambitious yet ultimately doomed plans to break into the local army camp for various reasons while trying to stay one step ahead of the army camp's leader Colonel Fuzzby.
This Pop! features Breezly Bruin, a comical, resourceful, polar bear, much like Yogi Bear himself. An absolute must for any Hanna Barbera fan. | eng | 7cd79244-24c3-496d-930f-c5ad2aa56770 | https://gameskeysaustralia.com/breezly-and-sneezly-breezly-pop-vinyl-figure |
"GOvember" – BCM Missions Month
Stacy Murphree
When is the best time to promote and encourage students to get involved in serving in missions? I always say start early in August and never stop! However, we have also found that having a week-long or month-long missions emphasis in the Fall semester has proven to be effective in focusing on missions and challenging students to go and serve. We use the month of November to do this. It is a strategic time in the Fall semester when students seem ready to pray and think ahead to spring break and summer missions opportunities. It's also a time when students are close to going home for the holidays and that can be a crucial time for having conversations with parents about serving in missions. It can also provide valuable connections with their home church, family, and friends for fundraising.
Here are some helpful "GOvember" ideas:
1. Missions Fair
Kick off your missions week or month with a missions fair. Before our weekly large group, we asked students who had served in missions the previous summer to host a table with information about where they served. They get creative! For example, students who had served with GenSend in NYC gave out cheesecake at their table and talked about their experiences in the city. We give each student who attends a "passport" to receive a stamp at each table. If you fill your passport, you get a chance to win a $100 mission trip scholarship.
2. Missions Coffee House
Plan a Coffee House night with live music, student missions testimonies, highlighting summer missions opportunities, and praying for the nations. You can also use it as a missions fundraising by adding elements such as a silent auction or selling different coffees and snacks from around the world.
3. Praying for Unreached People Groups
Use this time, not only to promote missions opportunities, but to really educate your students about unreached people groups around the world. As a BCM, provide times where you corporately come together to intercede for the nations and for the unreached. We incorporate a time into our weekly large group where a student leader shares how to pray for a specific unreached people group and then spend time in small groups praying. You can find a lot of resources at
4. Missions Monday
It does not have to be Monday but set aside a day each week during GOvember to specifically focus even more on missions. We host a different topic each Monday during the month to help students learn about different aspects of preparing to serve such as fundraising, spiritual preparation, and even how to talk to your family about serving in missions.
5. Social Media
Utilize social media as much as you can to promote missions during this time. Some ideas can include posting video testimonies from students who have served on mission and highlighting summer missions opportunities from your state BCM missions program, IMB, and GenSend.
6. Summer Missions Application Parties
Provide times where students can collectively come together for the purpose of working on their summer missions applications. This encourages new students who may have questions about the application process and provides opportunities for you to connect and pray with your students as they make decisions about their summer.
7. Serve Day
Provide a day during your missions month to serve locally as a group. We had the opportunity last year to serve in a nearby city where our students connected with refugees and learned about unreached people groups living near our city.
There are so many benefits to students going and serving in missions. They go and serve in a different ministry context, learning so much about evangelism and discipleship, which they can then bring back to their campus. Students mobilized to serve in missions return home energized about how they can serve their own campus and better grasp the concept of their campus as their own mission field. It's a "win-win" situation! Because of that, it is so important to have a strategy when it comes to promoting missions on your campus. Whether it's GOvember or another strategy, I am praying for God to mobilize many students on our campuses this year!
Stacy Murphreeserves as the Campus Minister at Austin Peay University's BCM. You can reach her at smurphree@tnbaptist.org or follow the ministry on Instagram @austinpeay | eng | 7cca79a8-8d41-4355-b34d-3f75721abbb8 | https://collegeministry.com/govember-bcm-missions-month/ |
Beautiful afternoon storm had just went through the area, there was a soft rain hitting the marsh. Looking out over the rain soaked marsh flats, I discovered the anchor point of my composition in a distant piece of diftwood. Using the tree to my left covered in spanish moss, the screen came alive with detail. The key to this capture would be maintaining foreground detail while catching the suttle light fading off the clouds in the distance. | eng | 8010ee2b-e32e-487a-8ea4-e92de341f272 | https://branningfineart.com/gallery/after-the-storm/ |
Tag: music
Experience the Unique Sound of Maxi Jazz's Vocals
Discover the Inspiring Music of Maxi Jazz
Maxi Jazz is a British musician and singer-songwriter who is best known as the lead vocalist and primary lyricist of the band Faithless.
Maxi Jazz was born Max Alfred Ellul in 1961 in Hampstead, London, England. He is the son of a Maltese father and an English mother. Jazz grew up in the London suburb of Totteridge and attended the University of Sussex, where he studied psychology and sociology.
Jazz first gained fame as a member of the band Faithless, which he co-founded with producer and DJ Rollo Armstrong in 1995. The band's debut album, "Reverence," was released in 1996 and featured the hit single "Insomnia," which became a club anthem and helped to establish Faithless as a leading act in the UK dance scene.
Over the course of their career, Faithless released a total of six studio albums, all of which were produced by Rollo Armstrong and featured lyrics written by Maxi Jazz. The band's music combined elements of dance, electronica, and trip-hop, and was known for its spiritual and philosophical themes. Faithless had numerous hits over the years, including "God Is a DJ," "We Come 1," and "Mass Destruction."
In addition to his work with Faithless, Maxi Jazz has also released a number of solo projects, including the album "Maxi Jazz and the E-Type Boys," which was released in 2013. He has also collaborated with a number of other artists, including Groove Armada and the Chemical Brothers.
Maxi Jazz is known for his distinctive voice and socially conscious lyrics, and has been praised for his ability to convey powerful messages through his music. He continues to tour and perform with Faithless and as a solo artist.
Get to Know the Talented and Visionary Maxi Jazz
Jazz began his musical career as a member of the band Dance 2 Trance, which was active in the late 1980s and early 1990s. He later co-founded Faithless with producer Rollo Armstrong in 1995. The group gained a devoted following with their blend of electronic, dance, and world music influences and their socially conscious lyrics. Some of their most popular songs include "Insomnia," "God Is a DJ," and "We Come 1."
Jazz is known for his distinctive voice and powerful stage presence. He has also worked as a DJ and has released several solo albums. In addition to his work in music, he has also been involved in humanitarian efforts and has supported various charities throughout his career.
In summary, Maxi Jazz is a talented and visionary musician who has made a significant impact in the electronic music scene. His unique style and commitment to social causes have made him a beloved and respected artist | eng | 1435fabf-1ad3-43d7-8e56-80c0b4ebc282 | http://www.hindigraphics.in/tag/music/ |
ST340 Programming for Data Science Assignment 1 Released: Friday week 2, 2021-1-22. Deadline: 12:00 on Monday week 5, 2021-2-8. Instructions • Links and instructions on how to submit can be found on the module website. • Work in groups of at least one and at most three. Group work is preferred. Please note that no special consideration for marking will be given to solo work despite more effort. • Specify your student numbers and names on your assignment. You need submit only one copy for each group. • Any programming should be in R. Your report should be created using R markdown. Submit two files: a knitted pdf document and the corresponding R markdown file. • This assignment is worth16% of your overall mark. 1. Mergesort is a divide and conquer algorithm for sorting an array. (a) Devise an algorithm, merge, that takes as input two sorted arrays and returns a single array with the elements of the two input arrays in sorted order. For example, with inputs (1, 3, 3, 6, 7) and (2, 4, 5) it should output (1, 2, 3, 3, 4, 5, 6, 7). If the lengths of the input arrays are n1 and n2, your algorithm should require O(n1 + n2) comparisons in the worst case. Describe, implement and test your algorithm. (b) The mergesort algorithm is recursive. Taking as input an array of length n it calls itself twice, once on the first half of the array and once on the second half of the array (with appropriate modifications if n is odd). It then uses merge to combine the output of the two recursive calls into an array, which it then returns. Describe, implement and test the mergesort algorithm. (c) Prove by induction that mergesort outputs its input array in sorted order. (d) Let T (n) be the total number of comparisons made by mergesort on an input of size n. Write a recurrence inequality for T (n), assuming n is even. Prove by induction that T (n) ≤ n log2 n for all n ∈ {2k : k ∈ N}. (e) Compare and contrast mergesort with quicksort in a few short sentences. 2. A simple version of the majority element problem is as follows. Let a be an array of n = 2k elements and ≡ be an equivalence relation for those elements. We want to find a majority element of a, which is an element that occurs in an equivalence class with strictly greater than n2 elements (e.g. if n = 8 then the element is equivalent to at least four others plus itself). Furthermore, we want to do this only using the ≡ relation and no < relations, i.e., we cannot order the elements. (a) Devise a recursive, divide and conquer algorithm to return the majority element x of a if it exists and which returns "no majority" if it doesn't. At each step, your algorithm should make two recursive calls and perform no more than 2n equivalence (≡) tests outside of these recursive calls. Remember to present your pseudo code. Explain why your algorithm works (by proving something). (b) Provide an upper bound on the number of equivalence checks that your algorithm makes on an input of size n, along the lines of Q1(d). 3. For this question you are encouraged to re-use as much of the code from Lab 2 as possible (include in your report only the parts you have changed). You are asked to compress them×n = 767×584 matrix representation of Nightingale in pictures.rdata in such a way that the accuracy of the approximation is counterbalanced by the space used. You are to use the greyscale representation computed in Lab 2 as the input matrix A. Specifically, you are asked to produce an integer k ∈ {1, . . . , n}, vectors b1, . . . , bk, d1, . . . ,dk and values c1, . . . , ck such that you minimize the function f(k, b1, . . . , bk,d1, . . . ,dk, c1, . . . , ck) = exp (‖A−B‖F ) + k(m+ n+ 1), where ‖ · ‖F denotes the Frobenius norm, and B = k∑ i=1 cibid T i . Use R to find the value of (k, b1, . . . , bk,d1, . . . ,dk, c1, . . . , ck) that minimizes f . Explain all computations you have done, including why your answer minimizes the function above. (You do not need to ensure that the entries of B are in [0, 1], which we did in the lab only to visualize the matrices.) You should not need to compute any matrices of the form of B to find what is required, nor do you need to print any of B, bi, di, or ci in your submitted answer. | eng | 029824dd-488e-48b9-b6cf-94971eca77d2 | https://www.xuebaunion.com/detail/633.html |
Do Immunity Shots Actually Work? We Asked A Nutritionist
Immunity shots and wellness shots, aka the tiny little bottles of juice you might spot at the grocery store, often claim to boost your immune system. And with illnesses like COVID-19, the flu, RSV, and the common cold running rampant, it might sound pretty promising. The reality is, they might not be the cure-all they claim to be. We chatted with registered dietitian nutritionist May Zhu to find out the truth behind immunity shots — and whether they're actually worth your money.
Expert interviewed:
May Zhu - May Zhu is a Chicago-based registered dietician nutritionist who works with with women to help them build healthier relationships with food.
What are immunity shots?
The 1- to 3-ounce drinks are typically made with juices (like ginger or citrus), vitamins, and minerals (think: vitamins C and D, turmeric, or zinc) — all of which are generally nutritious. Depending on the type, they might also be called ginger shots, apple cider vinegar shots, turmeric shots, or vitamin C shots. And many of the companies that make them promise they'll boost your natural immunity with just one or two swigs.
Do immunity shots work though?
There's usually nothing wrong with adding an extra dose of vitamins to your diet, said Zhu. But they're not the miracle drink you might think they are. "We really can't say there's enough evidence to support any type of therapeutic use to cure anything," she said. Meaning they won't necessarily keep you from getting sick.
While many of the ingredients in immunity or wellness shots are part of a balanced diet, the shots themselves can't replace whole fruits and vegetables. Because those also contain fiber, which supports both your digestive and immune systems, said Zhu. She recommends prioritizing getting fruits and veggies on your plate first, then introducing these drinks to help fill any nutrient gaps.
On that note, wellness shots also aren't a good substitute for other methods of staying healthy. Vaccines like the flu shot or COVID-19 vaccine can give your immune system an added layer of protection and actually prevent you from getting sick. While nutritious foods and staying hydrated can keep your body nourished with the vitamins and minerals you need. Pair that with hygienic practices like washing your hands, and you might be saying, 'Immunity shots, who?'
If I do want to try immunity shots, how often should I drink them?
Drinking one wellness shot every now and then isn't doing a ton for your health, said Zhu. To get the most health benefits from them, she recommends making them "a very regular part of your routine." Think: Every few days or once a week.
If you want to try them out but don't want to shell out the cash (they can cost $3 or more per bottle), you can make homemade wellness shots — or just incorporate some of the ingredients into your regular diet. Zhu says to look for natural sources of vitamin C like pineapple, orange, lemon, or lime juice for your DIY immunity shot recipe. As well as turmeric and black pepper, which are anti-inflammatory.
theSkimm
It might be tempting to stock up on wellness shots to keep you and your family healthy. But they aren't the quick fix you might be looking for. So prioritize those tried-and-true practices to really keep illnesses away — and feel free to add immunity shots into a balanced routine.
This content is for informational and educational purposes only. It does not constitute a medical opinion, medical advice, or diagnosis or treatment of any particular condition. | eng | 3a983c96-4461-4986-bbb5-b4143b096e78 | https://www.theskimm.com/wellness/immunity-shots |
How to Order a CMMS System
Wondering how to procure or order a CMMS / EAS system?
So you're using spreadsheets to track assets?
And it takes days to gather maintenance budgets?
Maintenance department got a call from NERC? EPA? Internal Audit Department?
Probably time to consider an easier way to track assets with a Computerized Maintenance Management System (CMMS).
"A computerized maintenance management system or CMMS is software that centralizes maintenance information and facilitates the processes of maintenance operations." In essence, it's a dynamic database that allows the user to easily obtain, and sort information about important assets that may have either high value or compliance needs. This would include, but not be limited to, electrical equipment, water systems, HVAC units and similar "utility"-type equipment. The good news is a CMMS system makes organizing maintenance wonderfully efficient and easy, including the headaches of budget projections and audits. The bad news is that getting one feels like the Wild West; you could be buying fools gold.
How Does CMMS Software Work?
CMMS software works by streamlining and automating all the operations related to maintenance and management of equipment. It works in three major points.
Point 1 – Data Gathering and Organization
"A place for everything and everything in its place" is a great way of stating the ultimate purpose of a CMMS; that is, to have all information, from circuit breaker nameplates to compliance/maintenance records. The basic principle behind CMMS software is that it provides a central repository for all relevant data related to an organization's maintenance operations.
This data can come from a variety of sources, including asset management systems, work order tracking systems, inventory management systems, and asset management systems. It should also be easily accessible.
Point 2 – Integrating and Streamlining Maintenance Operations
Once the data is entered into CMMS system, it helps with the coordination and management of all aspects of maintenance by ramping up information flow. This includes work order tracking, preventive maintenance scheduling, inventory management, and more.
By automating these processes, CMMS software helps organizations save time and resources while improving communication and coordination among different departments. This would include compliance needs, such as NETA, NERC, EPA, etc and being able to easily compile reports necessary for such compliance.
Point 3 – Reporting and Analytics
Finally, the CMMIS generates reports and analytics related to productivity, repairing, replacing, parts, cost, timing and more. These reports can be used to assess the performance of individual assets, identify maintenance issues, and track the progress of ongoing projects.
The goal is to provide managers with the information they need to make informed decisions about preventive maintenance, repair/replacement projects, and other aspects of their operations. How does one know if any spare transformers are in the network without it?
What to Ask For
The following points are extremely important and will avoid a lot of error in the future, as well as having to explain why a system that cost $20,000 with a completion of 3 months is now three-times that cost and in its fourth year. Therefore, please consider asking the following questions (and "your welcome" in advance).
Who is entering the data into the system (legacy format, field photos, digital files) and what is the cost?
Any technology can build a CMMS, but few deliver a working system with the data in it. If you plan on having your field team or internal technicians do the data entry/validation/gathering, remember that they too have a cost that should be considered. A typical qualified person to gather data/enter data for electrical systems can be anywhere between $65/hr to $200/hr. Gimba is one of the few that does this service and has strategic relationships with NETA companies throughout North America.
What are the hourly rates being charged for various activities?
Every technology company knows what their billings are, but few offer the information. Ask for a rate sheet. If they don't have one, then don't work with them. Quite often technology companies will show a price that is off the shelf (OTS), but then configuration of that system may have a consultants hourly rate of $150 or more. Additionally, changes that may be needed in the future may have to be done as source code programming, and a software engineer can be as much as $250/hr. Even the local plumber provides a rate sheet; so should your IT company.
What are the total costs over a 5-year period and what is the break-down?
Some companies, like IBM Maximo, will herald that the software is practically free. But the configurations required will be $524,000 and $300 per user. Therefore, be sure to ask for an NTE (Not-To-Exceed) figure that encompasses all that you need it to do. This would include data gathering, data entry, periodic data validation (someone coming and testing the system), training, support, and all activities related to maintaining that system. Technology companies tend to obtain margins from the questions that are not asked. Gimba is a company ( that always offers pricing on an NTE-basis.
Example:
The vast majority of Maximo integrations are done by third parties. As a result, TRM (example third party company) will be billing you $1,500 per month as a distributor of IBM products that is paid to IBM. This is an additional fee above the normal "per user" fees charged. The whole point of having a CMMS is to make life more organized and less complicated, therefore, be wary of the firm that has fees that are less transparent and more complicated.
Onsite verses Remote?
Don't be shy about asking if onsite configuration will be done. It should be. Remote meetings and offsite configuration is the main reason why technology integrations take longer than they should. Find a company that says "we can be there Monday"; not "start a chat log with our team in another state". Additionally, ask what is the make-up of any maintenance fees; that is, are you coming onsite and how often/what is the cost if not included. Gimba is a company that is onsite every six months to validate the system and this is included in the maintenance fees. | eng | 201bd073-0d66-475e-93bb-eddd73a10c41 | https://gimba.io/2022/07/14/how-to-order-a-cmms-system/ |
Scientists have created synthetic clones of the novel coronavirus SARS-CoV-2, the highly infectious virus responsible for the Covid-19 pandemic, within the space of just one week.
The synthetic clones of SARS-CoV-2 were created at the high-security laboratory at the University of Bern's Institute of Virology and Immunology in Switzerland. By recreating the little-understood virus, the researchers hope to offer other researchers the opportunity to find new methods to fight the ongoing disease outbreak. For example, the clones can be used as a tool to develop diagnostic tests, antiviral treatments, and vaccines.
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Viruses are effectively just genetic material, either DNA or RNA, wrapped in a protein shell. In the case of SARS-CoV-2, genome sequencing has shown that its "genetic code" is made up of a single-strand RNA molecule of about 30,000 bases containing 15 genes. Just for context, the human genome is in the form of a double helix of DNA molecules made of around 6.4 billion bases and about 25,000 genes.
Reported in the journal Nature this week, scientists used the "blueprint" of the genome sequence to reconstruct most of SARS-CoV-2's genetic material from synthetic DNA. The genetic material was then reassembled and introduced into Brewer's yeast cells (Saccharomyces cerevisiae), creating a synthetic version of SARS-CoV-2 that closely resembles the real deal. However, the researchers did observe some differences in replication.
Working at the high-security laboratory of the Institute of Virology and Immunology (IVI). IVI
Some viruses can be cloned using a method involving the bacteria Escherichia coli, but coronaviruses can prove tricky to clone using this technique. So, the researchers looked to a pre-existing method using yeast cells previously developed at the University of Bern, known as transformation-associated recombination.
"We replicated the virus within the space of a week," Professor Volker Thiel, an organic geochemist at the University of Bern's Institute of Virology and Immunology, said in a statement.
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"Our model system using yeast cells shows that it is ideally suited for reconstructing coronaviruses and other viruses," he added.
The speedy nature of this method could allow health authorities, pharmaceutical companies, and research labs to gain access to clinical samples without the need for transporting viral samples from elsewhere, which is often considered risky and can take a fair amount of time. While there is no word yet on how or when these newly developed synthetic clones will be used, the University of Bern said in their press release that the research "attracted the interest of the World Health Organization (WHO)" after it was published on the pre-print server medRxiv back in February 2020. | eng | 41a12b5c-07a8-4ab1-80c0-27a3b68035c2 | https://www.iflscience.com/scientists-create-synthetic-clones-of-the-novel-coronavirus-in-a-highsecurity-lab-55938 |
Menopause
Menopause is a natural biological process that marks the end of your menstrual cycles. It is diagnosed after you have gone 12 months without a menstrual period.
What are the First Signs of Menopause?
Hot flashes and night sweats. Hot flashes can make you feel warm or hot suddenly for no apparent reason. Your skin may turn red and may also cause a rapid heartbeat. These can be so intense they wake you up.
Trouble in sleeping. Waking up during the night or having trouble going to sleep can happen for lots of reasons and it may be a sign you are approaching menopause.
You feel moody. Moodiness around the menopausal period is due to the change in hormones. If you have had anxiety or depression in the past, your symptoms may worsen during menopause.
Forgetfulness. Forgetfulness can stem from not only menopause but also from stress. If you're worried that you are forgetting too much, let your doctor know.
Less interested in sex. Some women say they are less interested in sex or have trouble getting aroused when they are in menopause. It is due to the skin around your vagina may become drier. This can make sex hurt.
Some physical changes. You may also notice your hair and skin become drier and thinner. Some women gain weight during menopause. There is also the possibility that your body will become more fat around the waist and less muscle overall as well.
What are the 3 Stages of Menopause?
Perimenopause. It is the time leading up to menopause. During this time, hormone levels begin to decline and menstrual cycles become erratic and irregular. Hot flashes and dry vaginal skin are common menopause side effects.
Menopause. A woman who hasn't had a period for 12 months in a row has stopped producing the hormones that cause her menstrual cycle. Once this has occurred, you enter postmenopause.
Postmenopause. It is the time after menopause has occurred. Postmenopause is your lifelong state once it occurs. Heart disease and osteoporosis are among the health conditions associated with postmenopause.
What is the Average Age of Menopause?
Menopause can happen in your 40s or 50s, but the average age is 51 in the United States. Signs and symptoms, including changes in menstruation, can vary among women. Keep up with regular visits with your doctor for preventive health care and any medical concerns.
Treatment for Menopause
Menopause has NO TREATMENT. However, some medications help in relieving your signs and symptoms and preventing or managing chronic conditions that may occur with aging. Estradiol Valerate is a treatment of moderate to severe vasomotor symptoms associated with menopause. It is largely responsible for the development and maintenance of the female reproductive system. | eng | 0d326ace-8941-42ef-9eec-cf45a723fc28 | https://rx2go.com/menopause/ |
1. With 4K optical performance and 120-degree ultra-wide field of view, everyone in the meeting room can clearly enter the lens 2. Integrated audio is specially designed for sound effects in crowded rooms, which can provide extraordinary sound effects in small rooms 3. Three beamforming microphones and custom-tuned speakers make the meeting sound as exciting as the video 4. It can work after plugging in the USB port 5. Sensor pixels: 12 million 6. Interface: USB2.0 7. Resolution: 3840 x 2160 8. Frame rate: 30fps | eng | b88283d8-ca21-4cd2-a9df-cb68b30b3db3 | https://www.techlabmarket.com/products/logitech-cc4000e-12-0-million-pixels-120-degrees-wide-angle-4k-conference-camera-eu-plug |
TLDR Prioritize seeking professional help for mental health, value genuine connections with good people, and engage in passions to regain a sense of self and find support when struggling with relationships.
Key insights
🧑🔬
A psychologist can help you work through your thoughts and feelings, and together you can find ways to cope and improve your mental well-being.
💰
The speaker discusses the moral difficulty of putting off important decisions in life due to saving money, and suggests that sometimes it's worth it to just relax and spend money on pleasure.
Jeans Hi offers a free design project with 7 gifts and employment tips for the first 300 participants. 🗣️ The speaker may have to turn down a job offer due to sponsored living arrangements in another country. 👩💼 Women should assess if their partner is taking advantage of their career choices and dependence.
🤰
19:12
: Importance of genuine help and avoiding dependency during pregnancy and relationships; 🚶♂️💔: Coping with breakup and discomfort in Moscow; 🍺😭: Period of binge drinking and excessive crying led to loss of friends, sought help from psychologist and reduced drinking; 📝✍️: Practice handwriting recognition to not miss important notes.
🤔
25:43
The speaker discusses their struggles with making and maintaining friendships, but values genuine connections with good people.
👥
32:20
It can be tough to find friends who share your interests, but attending events and trips with strangers can help you connect and potentially find like-minded individuals.
🏠
37:58
Found a beautiful house on someone's profile in Moscow/St. Petersburg, emphasizing the importance of finding friends who share your values and needs beyond just common interests.
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42:10
It's important to distance yourself from toxic people and engage in your passions to regain a sense of self and find support when struggling with relationships.
| eng | 5bd36743-44d9-44f1-83ac-19f6c4f64f73 | https://eightify.app/summary/mental-health-and-therapy/prioritizing-mental-health-insights-from-chuvs-9-kotelnikova-aranova-lisevskii |
Autism refers to a large number of neurological disorders known as autism
spectrum disorders (ASD). ASD patients display difficulties in social
interactions and a large variety of accompanying symptoms which manifest the
complex genetic background underlying this disease. To date, over 2000 copy
number variations (CNVs) and 300 genes potentially linked to ASD have been
identified via array-based comparative genomic hybridization. However, the
physiological function of these genes and their relation to ASD is mostly
unknown. This thesis examines the potential of zebrafish as being, a suitable
model to functionally analyze such large number of potential neuronal disease
genes and their relevance for ASD. For this thesis the most frequently
reported ASD related CNV, located in the human 16p11.2 chromosomal region, was
chosen for analyses. This 500 kb long CNV encompasses 27 genes of which 22
orthologs and 6 paralogs exist in the zebrafish genome. This thesis
concentrated on only those zebrafish orthologs which are organized in syntenic
clusters in both zebrafish and human genomes as this conservation of genomic
organization indicates strong evolutionary pressure acting to preserve
functionally important gene interaction and regulation. Specifically, I
analyzed the zebrafish orthologs organized in two syntenic clusters on
chromosome 3 consisting of the genes kctd13, sez6l2, asphd1 and ppp4ca (and
ppp4cb), mapk3, gdpd3, ypel3. As a result of this thesis, it was identified
that all the analyzed genes are active in the brain during development. The
analysis by morpholino knockdown of: I) kctd13 and sez6l2 revealed a possible
connection to ASD by induction of head size changes, II) the ppp4c genes
resulted in heart and blood vessel deformations, which is in line with the
heart malformations present in some 16p11.2 CNV carriers. III) mapk3 induced
notochord, heart, and head deformations which are possibly related to the
neuro-cardio-facial-cutaneous syndrome. IV) ypel3 and gdpd3a resulted in
embryo mortality indicating their essential role during development. In
conclusion, this thesis establishes the possible involvement of kctd13 and
sez6l2 in ASD and more importantly serves as a case study that demonstrates
the potential of zebrafish as the preferred model system for identifying and
analyzing the molecular pathways involved in neurological disorders with
complex genetic background such as ASD. | eng | 9a771dfc-ab9a-4618-a5fa-e2b23f10b835 | https://refubium.fu-berlin.de/handle/fub188/5316 |
A letter to leaders
Dear leaders,
I wanted to write to you because there is silent suffering in your organisation.
As a conscious leader, I know that you want to know about it, and what can be done.
As a conscious leader, I know that you care about your people and you want to see them flourish and succeed with their endeavours. In some, there is something that is holding them back.
"The leaders who get the most out of their people are the leaders who care most about their people."
Simon Sinek
Chronic pain.
Chronic pain is arguably the number one global health burden. The suffering is immeasurable and the costs enormous (€441bn per year in Europe).
With one in five people being affected directly, perhaps more, and the effects upon their loved ones and their work colleagues, this is a significant problem for society. It is also a problem for businesses and organisations who are striving to achieve results and make an impact.
In a sports team, a player can choose to hide persisting pain. They may fear the consequences of admitting to the coach that they are suffering. Clearly this will depend upon the environment created by the leader. There is no difference between this and the workplace.
What are the pressures to look and operate in a particular way? Is there a perceived weakness? The reality is that the person needs help, support and guidance. We all need help, support and guidance. Even leaders who maybe feeling isolated at the top.
We know that levels of engagement at work affect results. Low levels of engagement and the reasons are understood. Beyond this will be the impact of chronic pain upon an individual's ability to engage and perform. Here is an opportunity to help another human being, and increase engagement.
Engaged teams have 21% greater profitability
Forbes
So, there is an opportunity. There are ways to address the problem of pain. And as a leader of people, I believe you will be interested to know what we can do. If you would like to hear my suggestions, please read on.
Create a space for people to come and talk
If people feel safe to talk, they can share their story. Then we can understand their needs and look at ways that we can help and support them. This positive approach has the knock on effect of creating a positive environment where the person and the wider community in the workplace feels heard and valued. This increases engagement.
As a leader, you can create the space.
Listen
Just listen. Hear what the person says so that you can truly understand. You are probably very good at this already. But we can continue to hone this skill.
Understand pain
One of the primary reasons that chronic pain persists is because pain is misunderstood.
Pain is a perception. The key players in pain are attention and expectation. Healthcare is built on a dualist model, seeking a physical cause for pain. This is a very limited way to view a complex experience that is only subjective and never truly measurable.
There are many reasons why pain, which can never be seen, increase and decrease. They include at least: the environment, the current and prior actions, the state of the person, their life story, their beliefs and outlook, the people around, the context.
Pain is embodied (it is always perceived within the boundaries of the body; even when the body part is no longer present) and embedded (within a context).
Each person's pain is unique to them. It is theirs.
As a leader, you do not need to have an in-depth understanding of the science of pain. You do need to understand that it is complex, personal and that you can help.
Pain can and does change
All perceptions change. They are not set in stone. This gives great hope together with the ever-evolving scientific understanding of pain.
Starting with understanding your pain, you can then move on to shape a positive future by creating new habits and building wellness. This includes pursuing a purpose.
A leader can help the person reconnect with their purpose.
Work as a means of transforming pain
Traditionally it is thought that the person needs to get better in order to return to work.
However, I suggest that in most cases we can turn this idea on its head. We can use return to work as a means of getting better and transforming pain.
This requires understanding, compassion and good communication on both sides. It also needs a good plan that is gradually progressed towards a picture of success.
Leading is not the same as being the leader. Being the leader means you hold the highest rank, either by earning it, good fortune or navigating internal politics. Leading, however, means that others willingly follow you—not because they have to, not because they are paid to, but because they want to.
Simon Sinek
Being there for someone who is suffering is one sure way of building and growing a relationship. As a leader, you can choose to take this approach.
In your business or organisation, it is likely that someone is suffering. Most likely in silence, or at least not sharing the extent of their suffering. This is impacting upon their life and yours.
Now you know that you can make a difference. You are not becoming a therapist or a doctor. You are being a person-focused leader.
If you would like an informal chat when I can listen to you and then share some thoughts, do let me know. | eng | 10bd778f-dd2b-474e-b481-78db9ca5b1cb | https://richmondstace.com/a-letter-to-leaders/ |
The Phosphagen pathway dominates the highest-powered activities.These are exercises such as sprinting, weight-lifting or throwing a ball. Training that concentrates on the phosphagen system is typically under 10 seconds in duration. Exercises with maximally fast bursts of muscle action against high loads are used.
This energy pathway is what we are training when we complete something like a 100m sprint or a 1RM lift in the gym. You might not be sweating the way you would with aerobic exercises, but rest assured, your muscles are working at their maximum capacity, and burning fat in the process!
The Glycolytic pathway dominates moderate-powered activities. Training that concentrates on the glycolytic system is typically a few minutes in duration. These are workouts like "Fran" or "Grace" – something that requires you to work at close to all out intensity for 3-7 minutes or so.
The Oxidative pathway dominates low-powered activities, lasting anywhere from several minutes to several hours. These are exercises at a steady pace over longer periods of time, such as long runs, bike rides, etc.
Anaerobic vs. Aerobic
The first two systems, Phosphagen and Glycolytic, are considered "anaerobic" while the third, Oxidative, is considered "aerobic."
Anaerobic training is unique in its capacity to dramatically improve power, speed, strength, and muscle mass. It also greatly benefits cardiovascular function and decreases body fat better than aerobic training. Anaerobic work is unsustainable past several minutes.
In fact, anaerobic training will also help develop aerobic capacity, where the inverse unfortunately is not true. Many endurance athletes recently have implemented anaerobic (sprint/explosive) training, and seen immense improvements in their performances.
Aerobic training helps vastly improve 2 of the 10 general physical skills – Cardiovascular/Respiratory Endurance and Stamina. It uses oxygen from the muscles and is what you know as "cardio." This is where running falls.
Which one should I be doing?
Aerobic exercises such as running, biking, and swimming are often regarded as being heart protective, but there is evidence that shows that anaerobic is at least as heart protective as aerobic exercise.
As a sole focus, aerobic training is inferior to anaerobic training for an individual concerned with total conditioning and optimal health.
Anaerobic exercise builds muscle; aerobic exercise burns muscle. This is evident at any elite level track meets – take a look at the body composition of the sprint athletes vs. the distance athletes. The difference you'll notice is a direct result of training at those efforts.
Completing anerobic exercises like heavy lifts and short bursts of speed enables you to not only to increase power and speed and burn fat, but also to increase your overall endurance.
So rather than completing long, grueling workouts every week, we primarily target this with shorter, more intense workouts in order to get the "most bang for our buck" in terms of training time and improved work capacity.
By constantly varying functional movements of the three main fitness activities of CrossFit (gymnastics, weightlifting, metabolic conditioning) and performing these movements at high intensity, we effectively build our anaerobic capacity as well as our aerobic capacity – forging fitter humans in the process.
So should I stop running for weight loss?
Not if you enjoy it! Does running help you lose weight? Not as well as some other options.
However, for a lot of people, running (or biking, swimming, whatever) serves more purposes than just cardio. For some, it's a way to de-stress, clear your head, or start fresh.
However, if you want to see more physical results, and continue to lose weight, you'll need to add in training that works the anaerobic side of things in addition to the aerobic. This is where the magic happens: where we see fat loss & muscle gain. | eng | a14be930-ec5c-4d88-a191-cfff9a2da0e8 | https://risingtidefit.com/why-running-isnt-helping-you-lose-weight-and-what-to-do-instead/ |
Introduction
The purpose of any teacher is to ensure the best education her students could get. Student learning should based on cognitive thinking skills and learning, not just declarative knowledge and basic skills. In the United States, however, high-stakes testing has complicated these efforts, and are used to process a student's knowledge and the effective ways of teaching. These high-stakes tests are being used to compare students, schools, and school boards across the nation for each district. Teachers and school administrators are often blamed for poor test results of students, that are then reported to the media.
High-stakes testing if used correctly can help a teacher know a student's strengths and weaknesses in school so as to better help them succeed. A high-stakes test is one that is given and graded under strictly monitored conditions. These tests are used in grades K-8 and once in high school to measure learning outcomes of students. Students typically take norm-based tests comparing their knowlegeability to a small part of student body in a norm-group. Other students undertake criteria-based testing to compare their knowledgeability or a standard of acceptable status in a certain area.
Issues with Teaching to Test
Very little people would argue against the necessity of providing teachers and students with the information on the procedure of a high-stakes test or its format. Even the brightest student could miss one item or more if they do not understand how a test is formatted and meant to be carried out. Teachers have to be taught what an appropriate time limit is for test taking familiarization yes but they also need not sacrifice important curricular content in the hopes ofHigh Stakes testing is a highly debated topic in the education field today. The goals that it seeks are widely criticized yet also praised by the public, mainly the government. The article which I read, entitled, "Issues in High-Stakes Testing Programs" by, Anthony E. Kelly and Finbar C. Sloane, touched upon the various pros and cons of the required state testing. Most importantly in their eyes was the view of the students upon the test results, "the impact of student motivation and morale is at the center of this discussion".…
First, the APA states that measuring what and how well students learn is an important building block in the process of strengthening and improving our nation's schools. Secondly, test results provide teachers with information on how individual students may be performing and provide feedback. Lastly, high stakes testing provides accountability, and therefore can help identify weaknesses and correct…
I think that, if there is strong evidence that high-stakes testing is producing disadvantageous outcomes, we should examine why and how we can reduce these negative effects. I am worried to know that high-stakes tests have been connected to reduced achievement, increased dropout rates, and reduced graduation rates, especially for minority populations. These populations are already suffering from such problems before we applied high-stakes tests and we do not want any more of them dropping out of school. They need to be in school, not out in the streets. We should study the causes and mechanisms that shape high-stake tests effects, in order to find out how we can change them.…
Both articles identify and analyze two different effects of high stakes testing. The first article doesn't directly attack high stakes testing but simply analyzes data and forms a conclusion. This would mean that it can be furthered explained to draw a conclusion about high stakes testing. The second article begins to show a negative side to the consequences of high stakes testing; therefore, it is more certain in its purpose. High-Stakes Testing and Curricular Control: A Qualitive Metasynthesis focuses on deciding whether high stakes testing has been able to take control of school curriculums and therefore identifies what changes it has made. Wayne Au analyzes his data collection to draw the conclusion that there are "three different, interrelated…
Education is one of the most significant things when it comes to making our children better leaders. In order to accomplish this goal there are many rules that are put into place. One of these rules is high-stakes testing. The controversy with high-stakes testing is that is it really helping the students or is it hurting the education system? In this paper I will discuss what high-stakes testing is, some pros and cons of high-stakes testing, and a way teachers can perhaps deal with high-stakes testing (High-Stakes Testing, 2014).…
Second, examinations are the measurement of the students' ability and diligence. Until now, teachers have been relying on testing systems as the ultimate means of evaluating and recording students' academic performance. Though this system may winnow out a few unfortunate talents, it is generally an effective indicator of the learners' knowledge, and nothing else has surpassed it. At the same time, students can also benefit from the tests, since tests highlight their strengths and weaknesses. Then, they know how to improve themselves for the next examination.…
expressed in a report by the Education Law and Policy(US). Published as a paper by education professors, the provenance is strong. It explains in depth the negative effects of high stakes testing. The report states that over 70% of the teachers have had to reduce teaching time in another subject to prepare for standardised testing. A clever anecdote personalises it by detailing the dismay of a teacher whose science experiment had to be stopped for the sake of test preparation. Therefore, the report is highly effective in making a non expert understand their plight.… | eng | 0b254b4a-f04f-46ce-a8d7-2af23785cda7 | https://www.studymode.com/essays/Does-Prepping-For-High-Stakes-Testing-Interfere-1382588.html |
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6 Science-Backed Benefits of Bee Pollen
April 2019
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It's allergy season and the last thing you thought you'd hear about was "bee pollen benefits."
Am I right?
Surprisingly the science behind bee pollen shows that it has many hidden health benefits, and while it gets a bad rap for being a common allergen for some people, there's plenty to know and love about bee pollen.
Bee pollen benefits most people, as it is very safe to consume. However, pregnant or lactating women, as well as people with known bee pollen or bee sting allergies are recommended to consult with a licensed physician or avoid it as a precaution.
Get ready to add bee pollen to your diet after you learn about all the wonderful bee pollen benefits you may have been missing out on:
Bee Pollen Benefits
Bee pollen is actually a remarkably potent natural substance with health and healing benefits we're still studying to fully understand. Some little-known facts about bee pollen:
#1 Important Source of Nutrition
Bee pollen carries more protein than pretty much any other animal source and also more amino-acids than an equal portion (in weight) of chicken eggs or meat.
#2 Bee Pollen for Allergies
Bee pollen is a natural remedy for allergy relief and has been used in traditional Chinese, Egyptian, and Greek medicine for more than 2,000 years. This may sound counterintuitive but research shows bee pollen benefits people and animals in different studies by reducing histamine production through mast cell inhibition. Over the counter medicine is mostly comprised of "antihistamines."
Antihistamines tend to cause drowsiness, which at times may be a helpful respite from sleepless nights due to allergies, but not so convenient during work hours. If allergies -or other things- are keeping you up at night try a nighttime tea like our Gold, and sprinkle some bee pollen on it.
#3 Bee Pollen Antioxidant Benefits
Free radicals are harmful cells with unpaired electrons that latch onto healthy cells and break them down, antioxidants protect the body against free radicals and their associated decay. Oxidative stress caused by free radicals has been extensively linked to chronic illnesses including cancer. Due to bee pollen's high antioxidant levels, it is being considered both as a a health food diet supplement, and for patients undergoing treatment for chronic disease.
#4 Bee Pollen for Weight Loss
There is no specific evidence pointing to a bee pollen weightloss connection; it is not a miracle supplement that can replace healthy eating habits and exercise. However, the bee pollen weightloss reputation comes from its metabolic boosting properties: bee pollen may help regulate hormones and increase metabolic rate, which eventually leads to fat burning.
Additionally, there are other ways in which bee pollen benefits your weightloss journey - as a low-calorie but high-nutrient substitute, good source of fiber, and as significant aid in muscle recovery through its high-protein content.
#5 Bee Pollen Benefits the Immune Response
Bee pollen benefits include antibacterial, anti-fungal, antioxidant, and antiviralproperties, thus stimulating and supporting the immune system. Several studies have found that bee pollen can be effectively used against some harmful bacteria, such as E. Coli, Salmonella, Staphylococcus Aureus, and Pseudomonas aeruginosa among others. Since they help mast cells (inside white blood cells) they support the immune response.
#6 Bee Pollen May Support Liver Detox
Animal studies have shown that bee pollen may have hepatoprotective properties against different kinds of liver damage and may even help repair alcohol and drug abuse damage. A 2013 study found that bee pollen promotes "liver cell healing" and compared it to similarly powerful milk thistle, considering bee pollen safer in some cases.
How to Consume Bee Pollen
Bee pollen comes in various supplement forms, they look like very small yellow, orange, brown or tan balls. The taste and protein content may vary according to the plant origin of the pollen, so it's important to research the product and read the label if you're getting it from the health-food store. Local farmers may be able to provide more insight on their specific type of pollen - don't be afraid to ask!
The flavor ranges from a little bitter to sweet and nutty and it makes a great addition to smoothie bowls, green juice recipes, and even salads as a low-calorie, high-nutrient, topping.
To leverage the best of the bee pollen benefits first make sure you're not allergic to bee pollen balls:
Talk to your preferred licensed physician or perform a small test at home, placing a couple of pieces in your mouth and waiting two minutes to chew and swallow. If no allergic symptoms develop in 24 hours (runny nose, sneezing, watery eyes, itchiness, red skin patches) then you may start testing with a gradual approach: add ½ teaspoon of bee pollen to your breakfast and go up to three full tablespoons within a four-week period.
If you have no known allergies or do not suspect one, try sprinkling one tablespoon a day in your breakfast.
Bee Pollen Uses
Now that you know how to consume bee pollen, take a look at this deliciously nutritious bee pollen uses so you can stop those allergies in their tracks, boost your immunity, and reap all the bee pollen benefits nature has to offer!
Bee Pollen on Yogurt, Cereal or Oatmeal
Just sprinkle on your favorite plain yogurt, cereal or oatmeal recipe. These are our top two faves!
Cacao nibs, bee pollen, and coconut flakes top this acai bowl that also rocks the banana-acai-berries combination, but with a chocolate twist. Recipe from The Movement Menu.
Bee Pollen Cookies and Granola Bars!
Yes! Given their at times nutty and somewhat sweet flavor, you can use them in cookies and granola recipes. You can also simply sprinkle them on a granola bowl of your choice.
Vegan, gluten-free, and sugar-free, these date, banana, and oatmeal cookies are actually pretty sweet and easy to make. Recipe from Umami and Me.
Raw granola bars with honey, bee pollen, nuts, and berries. Recipe by Azure Standard. The raw bars keep the living foods (bee pollen and honey) and their enzymes active, perfect to reap those bee pollen benefits.
As a Salad Topping or Salad Dressing!
You can add some natural protein, liver-detox, and immune support (those bee pollen benefits!) to your plain salad just by tossing some bee pollen on it. Or you can get creative and try some healthy salad dressings enriched with the nutty-sweet bee pollen flavor.
The Takeaway
Bee pollen benefits have yet to be fully studied and proven, but research shows that bee pollen for allergies may work for most people with mild to moderate allergies, by inhibiting mast cell activity that wrongfully releases histamine when a non-threatening substance is mislabeled as harmful by the immune system.
Bee pollen may also support weight loss, natural liver detoxification, and the immune system due to its high antioxidant properties and numerous nutrients. If you want to get the benefits of bee pollen, you can try adding it to teas, smoothies, acai bowls, salads, and even cookie recipes to gradual results.
If you have known bee stings and bee pollen allergies, are pregnant or lactating you may want to consult with a doctor before trying bee pollen. Otherwise, you may add this precious superfood to your diet starting at half a teaspoon and growing to up to three tablespoons per day. | eng | 4a0c33d3-8835-43cc-a228-5c097e2d9675 | https://www.organifishop.com/blogs/news/bee-pollen-benefits |
Camas
Here's why you need condo unitowners insurance
Condo
Insurance in and around CamasHere's why you need condo unitowners insuranceWould you like to create a personalized condo | eng | 807796fb-f3d1-4091-9c74-1138d227cf75 | https://julialo.net/insurance/condo |
Sure, it's your right to say whatever you want no matter how stupid or hateful, but is it a good idea? Are you doing yourself or society any favors? It's your perfect right to be an idiot but your idiocy, once loosed upon the general public, is another matter. You don't have the moral right to make other people suffer because you're stupid. Sometimes life is about more than what you have a right to do, but what you should or shouldn't do within the context of civilized society – which I submit, we should be aiming for. Civilization seems a worthy goal at this point.
America should be ashamed of producing so many stupid people. Virtually every one of whom has or had the potential to shine, and it was just never realized because we as a society are neglectful, especially of the poor and working classes. We do not have universal education any more than we have universal health care. In many cases, the poor just have a pipeline to prison.
There are aspects of our society, such as the failure to provide high quality education and social support to all, that encourage a culture of dumbassery. Think Confederate flag. Think prophet cartoons. Think sheer ignorance and cultural insensitivity.
I think virtually every human has the innate capacity to rise above such cultural backwardness. I think they have Ferrari brains like everyone else, they just never learn to shift gears. No one teaches them. They spend their whole lives driving a Ferrari poorly and never get it out of first gear. In that state, they are susceptible to dumbassery.
Two people are dead and one wounded because a bunch of dumbass macho yahoos down in Texas (who could have been so much more) thought it'd be cute to have a 'draw the prophet' contest...to prove they weren't afraid of Sharia law and shit.
'Hoo boy! Look at us! We ain't afraid of no durned Muslims and we ain't ashamed of being dumber than fucking dirt. It's our RIGHT!'
Hateful, ignorant and proud of it, what could be more American than that?
Ugly Americans, man. We got 'em. We produce them through our neglect, which we romanticize as a culture of rugged individualism, when what is truly meant is every man for himself. Which makes for a shit society that produces vast quantities of shameful dumbassery.
And yes, of course, the shooters were also at fault. Their actions, however predictable, were not remotely justified. But really, how smart is it to poke a grizzly bear with a stick just because you have the right to do so? Grizzlies don't like that shit - and we all know it.
We need to import some fucking shame from somewhere. Can we get a pipeline for that? | eng | e96ab737-f81a-42bb-bb31-23c79d06bad9 | https://www.dailykos.com/stories/2015/05/06/1382840/-The-unbearable-dumbness-of-American-as-holery |
Model-turned-TV personality Phoemela Baranda didn't lose sleep over being flat-chested, but when she crossed over to TV a few years ago, she started noticing how "flat" she looked. That was when she considered undergoing breast augmentation. | eng | 5214188e-0ed0-42fc-85ad-ae8be695597e | https://lifestyle.inquirer.net/tag/phoemela-baranda/ |
Stellenbeschreibung
Intro
CYCLE is looking for a Central Operations Manager to optimize processes, monitor KPIs, create SOPs, and provide support to local markets. The role requires strong analytical skills, project management abilities, and the ability to collaborate effectively with cross-functional teams. A background in operations management and experience in the logistics or delivery industry are desirable. CYCLE values diversity and is an equal opportunity employer.
Aufgaben
Optimize processes and tools to streamline operations
Monitor key performance indicators (KPIs)
Create standard operating procedures (SOPs)
Provide support to local markets
Stay updated on industry trends and emerging technologies
Identify areas of improvement in customer experience
Anforderungen
Bachelor's degree in Business, Operations Management, or a related field
Proven experience in operations management, process optimization, and team leadership | eng | 5f435337-6a12-4408-8c42-7149fa572f22 | https://www.getbaito.de/job/central-operations-manager-fmd-cycle |
Why are the SEE domain percentages different than those of the NCE?
Braden
January 20, 2022 15:53
Updated
The percentages in each domain of the SEE are equal, which is different than on the NCE. The equal number of questions in each domain will give students a robust sampling in each domain area. This will provide equally precise scores in each domain, to inform students of their relative strengths. The domain percentages of the SEE are as follows: | eng | cc83e8a4-ee54-46bb-8a04-86e4287f6dae | https://nbcrna.zendesk.com/hc/en-us/articles/4413548768667-Why-are-the-SEE-domain-percentages-different-than-those-of-the-NCE- |
You are here:
Cartwheel Galaxy
Rechercher les images et vidéos de l'Agence spatiale canadienne
This is an image taken by the Hubble Space Telescope. The Cartwheel Galaxy has this shape as the result of a violent galactic collision during which a smaller galaxy passed right through it. It produced shock waves that swept up gas and dust and sparked regions of intense star formation. (Credit: ESA/Hubble/NASA) | eng | f4dba460-a85d-4bfb-b3a2-860409ac7e39 | https://www.asc-csa.gc.ca/eng/multimedia/search/image/11938 |
Microsoft CEO: "Every App Is Going To Be An AI App"
Throughout a current incomes call with investors, the CEO of Microsoft, Satya Nadella, stated that artificial intelligence would become consisted of in all of the business's applications.
After discussing Microsoft's monetary performance for the last quarter, Nadella addressed concerns about AI and its expected integration into more products.
Given Microsoft's dedication to broadening its collaboration with OpenAI, it makes sense that investors would have questions about when Microsoft prepares to use the innovation it's purchasing.
Although Nadella wasn't going to give a particular date, he stated that AI would be incorporated into all of Microsoft's applications in the future.
In this post, we'll take a closer look at Nadella's statements concerning AI and briefly summarize the appropriate highlights from Microsoft's revenues report.
Nadella Says Every Microsoft App Will Be An AI App
Tyler Radke, the Lead Analyst at Citi, asked Nadella about the level to which AI will be utilized throughout Microsoft Azure, which is the cloud computing platform that runs its applications.
This was Nadella's action:
"I believe it's too early to sort of start in some way separating out AI from the rest of the work. I mean, even the work themselves, AI is simply going to be a core part of a workload in Azure versus simply AI alone. To put it simply, if you have an application that's utilizing a bunch of reasoning, let's state, it's likewise going to have a bunch of storage, and it's going to have a lot of other calculate beyond GPU inferencing, if you will. I study time, certainly, I think every app is going to be an AI app. That's, I think, the very best way to think about this change."
Nadella is saying it's prematurely to different AI into its own category due to the fact that it's becoming a core part of all products.
He believes AI will be incorporated into all apps gradually and will likewise be incorporated with storage and other types of calculating beyond just GPU inferencing.
In response to a concern from Keith Weiss of Morgan Stanley, Nadella expressed a similar belief, stating financiers ought to expect AI to be included in whatever.
"I think the way for our investors to see this is we essentially think that the next huge platform wave, as I stated, is going to be AI. And we strongly also believe a great deal of the business value gets created by simply being able to catch these waves, and then have those waves impact every part of our tech stack, and likewise develop new solutions and new chances …
And so, we completely expect us to sort of include AI in every layer of the stack, whether it's in productivity, whether it remains in our customer services."
Other Highlights From Microsoft's Incomes Call
Microsoft revealed that in the last quarter of 2022, it made $52.7 billion in revenue, which is 2% more than the year before.
However, the company's revenue is down due to decreases in operating earnings, net income, and profits per share.
Among the most noteworthy highlights is the increase in LinkedIn revenue by 10%. This suggests the professional networking platform is carrying out well which services can feel confident investing their time in it.
Another emphasize from the report is the boost in earnings for server products and cloud services by 20%. This growth was driven by the profits of Azure and other cloud services, which increased by 31%.
This indicates that Microsoft's cloud services are ending up being significantly popular in the market, which bodes well for the future of the company's collaboration with OpenAI.
In spite of a slight decrease in earnings, the business's general financial performance remains strong. | eng | 056eff7c-b830-45a5-9a2f-a9ee1123aa7b | https://bitechvn.xyz/microsoft-ceo-every-app-is-going-to-be-an-ai-app/ |
Neutron Music Player (Eval)
About Neutron Music Player (Eval)
English
The only true audiophile music player with Hi-Fi audio rendering and DSP engine
Neutron Player is an advanced music player with an audiophile-grade platform-independent in-house developed 32/64-bit audio engine which does not rely on the OS music player API and thus delivers truly unique experience to you.
* It outputs hi-res audio directly to the internal DAC (including USB DAC) and offers a rich set of DSP effects.
* It is the only application capable of sending audio data to the network renderers (UPnP/DLNA, Chromecast) with all DSP effects applied, including the gapless playback.
* It features a unique PCM to DSD real-time oversampling mode (if supported by DAC), so you can play your favorite music in DSD resolution.
* It offers the sophisticated user interface with an advanced media library functionality that is appreciated by audiophiles and music lovers from all parts of our world!
FEATURES
* 32/64-bit hi-res audio processing (HD audio)
* OS and platform independent decoding and audio processing
* Hi-Res Audio support (up to 32-bit, 1.536 MHz):
- devices with on-board Hi-Res Audio DACs
- DAPs: iBasso, Cayin, Fiio, HiBy, Shanling, Sony
* Bit-perfect playback
* Supports all audio formats
* Native DSD (direct or DoP), DSD
* Multi-channel native DSD (4.0 - 5.1: ISO, DFF, DSF)
* Output all to DSD
* DSD to PCM decoding
* DSD formats: DFF, DSF, ISO SACD/DVD
* Module music formats: MOD, IM, XM, S3M
* Voice audio format: SPEEX
* Playlists: CUE, M3U, PLS, ASX, RAM, XSPF, WPL
* Lyrics (LRC files, metadata)
* Streaming audio (plays Internet radio streams, Icecast, Shoutcast)
* Supports large media libraries
* Network music sources:
- SMB/CIFS network device (NAS or PC, Samba shares)
- UPnP/DLNA media server
- SFTP (over SSH) server
- FTP server
- WebDAV server
* Output to Chromecast (up to 24-bit, 192 kHz, no limit for a format or DSP effects)
* Output to UPnP/DLNA Media Renderer (up to 24-bit, 768 kHz, no limit for a format or DSP effects)
It is a time limited (5 days) full-featured evaluation version. Unlimited version is here:
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What's New in the Latest Version 2.22.2
Last updated on Jun 4, 2023 | eng | 074b2ae3-9ed6-483c-b5e7-19802ddbab49 | https://apkpure.com/neutron-music-player-eval/com.neutroncode.mpeval |
Anaemia Symptoms in Pregnancy
Anaemia is a medical condition caused by the deficiency of healthy red blood cells in the blood. It is a common issue among expectant women. When pregnant, body produces excess amount of blood to supply nutrients required to nurture the growing baby. The increase in blood requires increased amount of iron, folate and vitamin B 12, the deficiency of which leads to anaemia in pregnant women.
Anaemia can become severe amongst women -who are strictly vegan, women carrying multiples, have had two pregnancies close together, experience heavy menstrual flow and suffer from nausea frequently.
Anaemia could be easily treated by taking iron supplements in the fom of tablets. Folic acid supplements and vitamin B 12 supplements are also given to anaemic women. A diet rich in dairy, poultry, fish, meat and greens is advised to be taken by pregnant mothers.
Iron supplements could lead to constipation and irregular bowel movements. Drinking lots of fluid, and eating fibre rich food could tackle the problem to a great extent.
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What is anaemia?
Anaemia is a condition in which the blood does not have enough healthy red blood cells or the red blood cells do not have enough haemoglobin. In either case the cells in our body do not get the required amount of oxygen.
Why are pregnant women more likely to get anaemia?
The body of an expecting mother naturally produces excess amount of blood (nearly 50% more) to help provide nutrients to the growing fetus. Making extra blood cells requires plenty of iron, folate, and vitamin B12 to make the extra haemoglobin needed. Hence many women become anaemic during pregnancy unless they take in iron supplements.
Other factors contributing to anaemia during pregnancy include:
* Carrying multiples.
* Having two pregnancies close together.
* Having heavy menstrual flow before pregnancy.
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* Frequently experiencing nausea.
* And being strictly vegan.
Types of anaemia an expectant woman encounters:
Iron deficiency anaemia
This happens when the body does not have enough iron to produce adequate amounts of haemoglobin. In such case , the blood can not carry enough oxygen throughout the body. Iron deficiency is the most common cause of anaemia in pregnancy.
Folate deficiency anaemia
Folate is a vitamin which helps to synthesise new cells, including red blood cell. Pregnancy increases the demand for extra folate, the deficiency of which leads to anaemia.
Vitamin B 12 deficiency
The body needs vitamin B 12 to form healthy red blood cells. When a pregnant woman does not get enough vitamin B 12 from her diet, her body cannot produce enough red blood cells.
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Symptoms of Anaemia in Pregnancy
Paleness of skin, lips and nails
You look washed out. When you examine yourself in the mirror, you would notice that your natural glow has faded. There is a ghostly whiteness to your skin. The paleness happens because your blood vessels contain fewer red blood cells. General fatigue and morning sickness also contributes to this paleness.
Paleness of the mucosa of the inner, lower eyelid
In healthy women the inner lining of the lower eyelid is red or pinkish, but anaemic women have very light coloured mucosa with a tinge of redness.
Weakness and tiredness
Expectant mothers generally feel tired and worn out due to the hormone rush and other changes in the body during pregnancy. As a result this sign of anaemia goes unnoticed. Since symptoms of anaemia are not very noticeable, doctors suggest women to take a vitamin supplements with at least 30 mg of extra iron to protect against anaemia.
Breathlessness
Shortness of breath is very much a part of anaemia. Even a small flight of stairs makes you winded. Your growing belly and anaemia can make your body feel overwhelmed and gasping for air. Breathlessness can make even small daily activities feel like running a marathon or climbing Mount Everest.
Palpitations or irregular heart beat
This is also called tachycardia. This heart skipping sensation could be really terrible. It makes you nervous and anxious. Rapid heart beat occurs when your growing fetus is not getting enough blood and oxygen to tissues throughout her body. Your heart tries to compensate the deficiency by pumping more blood, which leads to palpitations. You can also feel a feeble murmur in your heart when it is stressed out.
Dizziness and headache
Pregmant women experience a sensation of spinning otherwise called vertigo or dizziness when anaemic. Women feel like fainting and light headed. Headache is also very common in anaemic women.
Difficulty in concentrating
With dizziness, fatigue, headache and weakness anaemic pregnant women feel cofused and find it difficult to concentrate on anything.
Strange food cravings
As the body craves for iron, pregnant women can have strange cravings for inedible things like clay, brick ,chalk and dirt etc.
Treatment for Anaemia
* Iron supplements in the form of tablets- ferrous sulphate is commonly prescribed for pregnant women.
* Folic acid supplements are generally given in the first trimester.
* Vitamin B 12 supplements are also prescribed.
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* A rich diet of animal products like eggs, fish, meat and milk are recommended to be taken. Lots of green leafy vegetables, legumes and whole grains are also advised to be included in rhe diet.
* If the expectant mother's iron level is dangerously low, injections of iron are prescribed or a transfusion of blood becomes necessary.
It is important to note that iron tablets cause constipation ,stomach upsets and change in color of your stools to black or dark green , so include fibre in your diet and also increase the intake of fluids to manage the side effects.
Conclusion:
Most of the symptoms of anaemia are similar to the general symptoms of pregnancy. This similarity could sometimes lead to overlook the condition. Regular monthly prenatal check up is hence mandatory for all pregnant ladies. However, your practitioner would prescribe iron supplements in your general medication to guard you against ana | eng | fc6d55a0-6bb3-42ba-a2e4-87cd87ced19f | https://parentinghealthybabies.com/anaemia-symptoms-pregnancy/ |
Are Citronella Ants Poisonous?
Citronella ants look like termites due to their similar nesting habits and appearance, as they infest moist wood and get attracted to moist areas. Every species of ants has a different level of toxicity and poses a varying degree of danger to their prey, humans, pets, and plants.
Are Citronella Ants Poisonous? Citronella ants are not poisonous as they possess non-venomous material in their poison glands that causes no painful sensation if they bite or sting. They can bite with powerful jaws but avoid stinging the prey's body. They are not harmful to humans but they can damage plants.
A few species are poisonous, like fire and bullet ants, but many ant species are not harmful due to their non-toxic secretions. | eng | ca109f9a-15f0-4ffa-9ef1-8919a20f696d | https://antsauthority.com/are-citronella-ants-poisonous/ |
Bystand my submission for Ludum Dare 32.
In this game, you are the victim of the unconventional weapon, as you flee for you life from a toxic warhead. Your only objective is to survive, but will you make it before the cloud of toxic gas engulfs you. | eng | 69152c12-2852-4f9f-975c-7819725ac110 | https://www.newgrounds.com/portal/view/656530 |
Swirl Anal Snake 18"
How many bulging ribs can you take from this extra long dildo? This firm, but flexible dildo has a boldly ribbed texture to give you even more sensation during penetration. How far are your willing to go? The powerful suction base anchors to most flat surfaces so that you have the ultimate control, even during solo play. | eng | ef7d28f2-3ba1-465f-858f-ffc16cd86629 | https://kirg.ee/en/swirl-anal-snake-18 |
Three 20th Century Barometers
Invented by Italian physicist and mathematician Evangelista Torricelli in the 1600s, a barometer is a meteorological device that measures pressure in the atmosphere. Barometers measure air pressure, helping forecasters predict the weather. There are two common categories of barometers: mercury and aneroid barometers.
Besides being used in weather forecasting, barometers can also be a unique and collectible home décor, especially those that were designed and built during the 20th century or earlier.
Three 20th Century Barometers
Antique barometers come in various types, including banjo barometers, stick barometers, and pocket barometers. Below are some barometers from the 20th century that you'll want to display in your home or add to your collection.
Sputnik Barometers were made during the mid-1900s in Germany, taking inspiration from the series of satellites that were launched by the Soviet Union in the late 1950s.
This mid-century barometer weather station is a multi-purpose device that includes a barometer as its main feature. It also comes with a thermometer for measuring temperature and a hygrometer for testing humidity. The instruments are housed in a globe made of clear plexiglass. The sphere housing the device sits atop a black compass that slots onto a wooden stand. The stand is adorned with a support ring made from brass.
This rare barometer is not only an eye-catcher but also an interesting conversation starter, whether it is displayed on a bookshelf, dresser or coffee table.
A barograph is a type of barometer that continuously records changes in atmospheric pressure in the form of a graph. Changes are logged on a sheet or a rotating drum through a writing arm that rises and falls, depending on barometric pressure. Barographs are essential in marine operations, predicting weather conditions at sea to help sailors in planning their course.
Short & Mason, a company renowned for making precision weather instruments which was founded in London in 1864 made this marine barograph. It is a one-of-a-kind barograph that was used on the MV Lady Aryette. The barograph, together with the rotating drum, is set inside a painted metal case. On one side of the drum barometer is a glass panel that displays the device, while on the top is a metal carrying handle.
Pocket barometers, as the name suggests, are miniature versions of a barometer. Pocket barometers were manufactured in the 19th century and worn in waistcoat pockets. Hikers and balloonists typically use them as most pocket barometers also function as an altimeter.
This pocket barometer is an aneroid barometer, which measures air pressure using mechanical parts instead of mercury. It comes in its original leather casing with a purple velvet lining.
What's the Weather Today?
If you're looking for antique barometers for sale, check out our wide selection of collectibles here. Should the piece you're looking for is not in our collection, we can help source it for you. | eng | 78b9b449-dbd7-4d1b-ba4c-c05c66f26b31 | https://dutchtimepieces.com/2021/07/08/three-20th-century-barometers/ |
Birding
A Bird Watcher's Paradise
The Sequim-Dungeness Valley is a bird watcher's paradise. From bald eagles and Peregrine falcons to black brant and bufflehead, hundreds of air and waterfowl have been seen on the Olympic Peninsula.
Dungeness Spit & National Wildlife Refuge
More than 250 species of birds, 41 species of land mammals, and eight species of marine mammals have been recorded in the Dungeness Spit and National Wildlife Refuge. It provides critical habitat for a number of species, some of them threatened or endangered, and is an important stop for many birds during migration.
Railroad Bridge Park & Dungeness River Nature Center
The Dungeness River Nature Center conducts a variety of programs for birding enthusiasts, including Wednesday morning bird walks, Birdfest in April, and the Christmas bird count.
John Wayne Marina
Best at ebb and flood tides, scan the John Wayne Marina bay and breakwater from numerous vistas.
Washington Harbor, Schmuck Road & Port Williams
During spring and summer, bald eagles nest along Washington Harbor. From Port Williams watch for the elusive tufted puffin traveling to and from Protection Island. Northern harriers and Savannah sparrows nest in the grasslands along Schmuck Road.
Dungeness Bay, 3 Crabs
Diverse habitats are found in this very small area, which includes the Saltwater Bay along the Strait of Juan de Fuca, the Dungeness River delta, extensive grasslands, ponds, and salt-marsh.
Olympic National Forest: Upper Waters of the Dungeness River
The birds found here are mountain species and birding is at its best in early morning and late afternoon. | eng | e5e4c4c7-e1be-425f-a7f3-e6a0816d4e51 | https://www.visitsunnysequim.com/91/Birding |
Unveiling the Head: A Dive into Psychological Wellness Assessments
The exploration of psychological wellness and its assessment is essential for cultivating a modern society that prioritizes the wellbeing of folks. With mental health problems turning out to be progressively prevalent, it is critical to delve into the depths of knowing and addressing them. Psychological health assessments serve as the basis for figuring out, assessing, and offering suitable help to individuals in require.
Mental wellness benchmarking and wellness and wellbeing benchmarks enjoy a essential role in location the phase for thorough assessments. These benchmarks give a standard in opposition to which psychological wellness can be measured, making it possible for for a regular and comparative evaluation across numerous contexts. By creating a benchmark, corporations and folks alike can gauge the usefulness of their endeavours, identify regions of advancement, and proactively tackle mental well being issues.
In the realm of the place of work, the utilization of place of work wellbeing tools and office psychological health evaluation resources is instrumental in producing a nurturing environment for personnel. These equipment enable companies to evaluate the mental well being standing of their workforce, discover potential dangers or problems, and apply specific interventions to market general wellbeing. Occupational psychological well being assessments get into account the special stressors and needs of certain professions, ensuring that assistance methods are customized to address the intricacies of various operate environments.
By embracing mental wellness assessments, organizations actively cultivate a lifestyle that acknowledges the significance of psychological wellbeing. Getting a proactive approach to place of work mental well being evaluation not only fosters employee satisfaction and efficiency but also decreases the stigma bordering mental health troubles. This sort of assessments provide a system for open discussions, destigmatization, and the implementation of holistic help programs.
As we enterprise into the area of benchmark psychology, the significance of mental well being assessment is even more magnified. By establishing standardized benchmarks and regularly assessing mental overall health parameters, we can decipher traits, evaluate development, and steer the system towards much more effective strategies. Mental wellness benchmarking serves as a compass, guiding our collective mission to prioritize and nurture the emotional and psychological welfare of men and women in all factors of existence.
Comprehension Psychological Health Assessments
Mental overall health assessments are essential resources that offer perception into an individual's psychological nicely-currently being and assist determine any likely issues or pitfalls. These assessments serve as benchmarks for measuring and understanding mental well being, both in private and professional contexts. By utilizing numerous techniques and methodologies, mental health assessments allow us to appraise and check the psychological effectively-currently being of individuals, contributing to a healthier and more supportive atmosphere.
One particular important aspect of mental overall health assessments is the utilization of wellness and well-getting benchmarks. These benchmarks act as reference points, making it possible for us to examine an individual's mental health from proven standards. By understanding these benchmarks, we can achieve a clearer photo of someone's mental nicely-becoming and determine any areas of concern. Such comparisons can help experts in applying acceptable interventions or assist programs, customized to an individual's exclusive needs.
In perform configurations, the use of workplace mental health assessment instruments and place of work psychological health danger assessments has gained considerable importance. These instruments aid businesses identify and deal with likely mental well being hazards and issues existing in the place of work. By conducting regular assessments, businesses can greater recognize the psychological well-getting of their staff and get proactive actions to encourage a more healthy perform environment. Moreover, occupational psychological overall health assessments permit companies to recognize any work-related factors that could impact their employees' mental overall health, major to much more targeted interventions and help systems.
In summary, psychological health assessments perform a important part in measuring, comprehending, and advertising psychological effectively-getting. By utilizing benchmarks, place of work tools, and chance assessments, these assessments permit us to recognize locations of worry and employ essential interventions to support individuals in their mental health journey.
The Significance of Place of work Psychological Health Assessments
Psychological overall health is a vital factor of total effectively-getting, and its importance in the office can't be overstated. The implementation of workplace mental overall health assessments plays a pivotal role in making certain the health and well-getting of staff. By using drug rehab Tempe and overall health and wellbeing benchmarks, these assessments give worthwhile insights into the state of employees' psychological wellness.
A place of work wellbeing tool this kind of as a office mental well being evaluation instrument will help organizations gauge the mental nicely-being of their workforce. It permits businesses to determine any prospective dangers or problems that may be influencing their employees' psychological well being. By having a comprehensive understanding of the psychological health landscape inside the workplace, companies can consider proactive measures to address and boost worker properly-currently being.
In addition, workplace psychological wellness danger assessments are vital for pinpointing particular occupational variables that may possibly impact employees' mental wellness adversely. These assessments let corporations to pinpoint locations in the place of work atmosphere that may be contributing to anxiety, anxiousness, or other mental overall health challenges. By addressing these aspects, businesses can generate a healthier and much more supportive function setting, hence marketing all round worker properly-currently being.
In summary, office mental wellness assessments are integral in selling a mentally healthful work surroundings. By utilizing benchmark psychology and well being and wellbeing benchmarks, employers can acquire valuable insights that empower them to make informed decisions concerning personnel mental overall health. Proactive measures taken dependent on these assessments not only benefit individuals but also add to the accomplishment and efficiency of the firm as a whole.
Employing Efficient Mental Wellness Benchmarking
To make sure the profitable implementation of psychological overall health benchmarking, several key factors want to be considered. First of all, organizations should prioritize the institution of obvious health and wellbeing benchmarks that align with their specific objectives and aims. These benchmarks provide a framework for measuring and assessing mental overall health results inside of the workplace.
Next, it is crucial to employ powerful place of work mental well being assessment resources. These tools permit businesses to get knowledge and insights concerning staff mental wellness and wellbeing. By frequently utilizing such tools, businesses can identify likely dangers and proactively tackle them, fostering a more healthy work environment.
Moreover, corporations need to recognize the significance of occupational mental wellness assessments. These assessments, personalized to the distinctive needs of a variety of task roles, assist recognize particular difficulties and risks that men and women may possibly confront in their function settings. By utilizing occupational psychological well being assessments, businesses can greater comprehend and address the psychological wellness concerns of their workers, bettering overall wellbeing and functionality.
In summary, profitable implementation of psychological overall health benchmarking demands very clear well being and wellbeing benchmarks, powerful office mental well being evaluation instruments, and an knowing of the relevance of occupational mental health assessments. By adopting these practices, companies can create a supportive and flourishing office surroundings that prioritizes the mental overall health and wellbeing of their employees. | eng | 5e26e93d-b5ce-4b9b-a2f2-843080c5c0db | https://kegsnearme.co.uk/unveiling-the-head-a-dive-into-psychological-wellness-assessments/ |
DISCLOSURE: This page may contain affiliate links, meaning when you click the links and make a purchase, we may receive a commission.
Queens County, Ireland
(County Laois)
Historical Description
QUEEN'S County, an inland county of the province of LEINSTER, bounded on the east by the counties of Kildare and Carlow, on the north by the King's county, on the west by the same and Tipperary county, and on the south by the counties of Kilkenny and Carlow. It extends from 52° 46' to 53° 10' (N Lat.), and from 6° 56' to 7° 48' (W. Lon.); and comprises an area, according to the Ordnance survey, of 396,810 statute acres, of which 335,838 are cultivated land, and 60,972 are unprofitable mountain and bog. The population, in 1821, amounted to 134,275; and in 1831, to 145,851.
The slight notices of Ptolemy respecting the interior of Ireland lead to the inference that this county was inhabited by the Brigantes; but Whitaker asserts that the Scoti were the first settlers in it. Afterwards it was divided into Leix, which comprehended all that part of the county contained within the river Barrow to the north and east, the Nore to the south, and the Slieve-Bloom mountains to the west; and Ossory, which included the remainder. So early as the middle of the third century the latter of these divisions, with parts of the adjoining counties, was ranked as a kingdom, and annexed by Conary, King of Ireland, to his native dominion of Munster, instead of being, as formerly, attached to Leinster. Subsequent passages of history prove it to have been a district of considerable importance. When Malachy was forming a confederacy of all the native princes against the Danes, the king of Ossory was specially required to conclude a peace with the people of the northern half of the island, in order that all should be at liberty to act against the common enemy; and in the time of Cormac Mac Culinan he had the command of the first division of that monarch's army in his unjust and unfortunate invasion of Leinster, and fell in the battle of Maghailbe, in which Cormac himself was slain. His dominions were afterwards disposed of by Flan, King of Ireland. Both Leix and Ossory were visited by St. Patrick in his peregrinations through the island to establish the Christian religion. In the war waged by Roderic O'Conor, King of Ireland, against Dermod Mac Murrough, King of Leinster, which led to the invasion under Strongbow, the king of Ossory was one of the princes who were specially summoned by the former of those potentates. The district was then subject to the Mac Gillypatricks or Fitzpatricks, who acted with so much vigour against Mac Murrough that, when the English had partially established themselves in the country, Mac Murrough prevailed on them to join him in an invasion of Ossory, which they ravaged, notwithstanding the gallant resistance made by Donald Fitzpatrick, then king. Though defeated, this toparch persevered in his determination not to treat with Mac Murrough, and was again defeated and forced to seek refuge in Tipperary. He afterwards formed an alliance with Maurice Prendergast, who, upon some offence received from the king of Leinster, had quitted the service of that monarch, and both invaded the neighbouring territory of Leix, which they ravaged with little opposition, until O'More, then dynast of it, was compelled to apply to Mac Murrough, by whom, aided by the English, he was quickly reinstated. Prendergast and Donald subsequently quarrelled, and the former, after skilfully extricating himself from an ambuscade laid for him by the other, retired with his followers in safety into Wales. Donald, though twice defeated, was not subdued. The position of his territory on the confines of Munster and Leinster afforded him opportunities of intercepting the communications between Waterford and Dublin, of which he availed himself so effectually, that a league was formed against him by Strongbow (who on Dermod's death succeeded to the kingdom of Leinster) and O'Brien, King of Limerick. But the appeal to arms was prevented by a treaty, in effecting which Maurice Prendergast, who had returned to Ireland, rendered his old ally good service. From this time Donald continued faithfully attached to his new friends. His territory was the place of rendezvous for their army when it was preparing to march against Donald O'Brien, King of Limerick, who had now declared against the English; and he proved his adherence still further by guiding the army through the woods till it encamped before Limerick. At this time the whole of the district now forming the Queen's county was known by the name of Glenmaliere and Leix: the latter division was made a county palatine; and on the division of the immense possessions of William, Earl Marshal, between his five daughters, it was allotted to the youngest, who had married William de Braosa, lord of Brecknock. Their daughter Maud married Roger Mortimer, lord of Wigmore, and from this connection the imperial house of Austria, and the royal families of Great Britain, France, Prussia, Denmark, Holland, Sardinia, and Saxony, derive their descent. Mortimer preferring to reside on his English estates, employed one of the O'Mores to defend and manage his Irish property, who, within twenty years after, became so powerful that he held it as his own, and became one of the most turbulent opponents of the English settlers in that part of the pale. So fully was his authority recognised as lord of the district, that he was summoned by the English government to oppose Bruce and the Scotch. For two centuries after, the district was the seat of an almost incessant war between the O'Mores and the English; which was carried on without any occurrence of much historical importance on either side. During the same period the Mac Gillypatricks, or Fitzpatricks, maintained their independence in Ossory, but generally adhered to the English. In the 5th year of Mary, both districts were reduced to shire ground, and incorporated under the name of the Queen's county, the assize town being named Maryborough, in honour of the Queen. But this new arrangement did not immediately tranquillize the country. At the close of the reign of Elizabeth, Owen Mac Rory O'More was so powerful that Sir George Carew, president of Munster, accompanied by the Earls of Thomond and Ormonde, was induced to hold a parley with him, to bring him back to his allegiance, in which they were entrapped in an ambuscade, and the Earl of Ormonde made prisoner, and detained till he paid a ransom of £8000. The daring insurgent himself was shortly after killed in a skirmish with Lord Mountjoy; and the followers of the O'Mores were driven into the counties of Cork and Kerry, then nearly depopulated. At this juncture many English families, to whom grants of the lands thus forfeited had been made, settled here. Seven of them, whose founders were most influential in securing the new settlements, acquired the names of the Seven Tribes. The families so called were those of Cosby, Barrington, Hartpole, Bowen, Ruish, Hetherington, and Hovenden or Ovington, of whom the first only has retained its possessions; that of Barrington, still extant, has alienated its property; all the rest are extinct in the male line. In the reign of Chas. I., large grants of land were made to Villiers, Duke of Buckingham, now forming the extensive manor of Villiers, which has descended through the female line to the present Duke. In the same reign, and during the unsettled period of the Commonwealth, the families of Pigott, Coote, Prior, Parnell, and Pole settled here: those of Vesey, Dawson, Staples, Burrowes, and Johnson, obtained lands in it after the Revolution. The county had its full share of the calamities of the civil war in 1641, at the beginning of which the insurgents secured Maryborough, Dunamase and other places of strength. The Earl of Ormonde arriving at Athy from Dublin, detached parties for their relief; on his retreat the whole of the county submitted to General Preston, but was forced again to submit to the royal arms. In 1646, Owen Roe O'Nial seized upon several forts in it. In 1650, Cromwell's forces entered the county and met with much resistance: in the course of the struggle most of its fortresses were dismantled by his generals, Hewson and Reynolds. During the Revolution of 1688, a signal victory was gained by the troops of William at a noted togher or bog-pass near Cappard, where they defeated a much superior number of the Irish. After the termination of the war, the country was so harassed by the ravages of the rapparees that the resident gentlemen applied to King William to have a force of infantry and dragoons quartered in it, and specified the castle of Lea as one of the principal stations for their reception.
The county is partly In the diocese of Killaloe, partly in those of Dublin and Glendalongh, partly in that.of Kildare, but chiefly in those of Ossory and Leighlin. For purposes of civil jurisdiction it is divided into the baronies of Ballyadams, Cullinagh, Maryborough East, Maryborough West, Portnehinch, Slievemargue, Stradbally, Tinnehinch, and Upper Ossory. It contains the greater part of the borough and market-town of Portarlington; the disfranchised borough, market, and assize town of Maryborough; the ancient corporate and market and post-town of Ballinakill; the market and post-towns of Mountmellick, Mountrath, Stradbally, and Ahbeyleix; the post-towns of Burros-in-Ossory, Rathdowney, Ballybrittas, Clonaslee, and Ballyroan; and the suburb of the borough of Carlow called Graigue: the largest villages arc those of Ballylinan, Castletown, Emo, Newtown and ArIes. It sent eight members to the Irish parliament, two for the county at large, and two for each of the boroughs of Portarlington, Maryborough, and Ballinakill. Since the Union it has been represented by three members, two for the coanty, and one for Portarlington: the election for the county takes place at Maryborough. The constituency, as registered up to Feb. 1st, 1836, consisted of 405 £50, 210 £20, and 1210 £10, freeholders; 5 £50, 16. £20, and 97 £10, leaseholders; 26 £50, and 72 £20, rent-chargers; and 31 clergymen of £50, in right of their respective incumbencies, 8 of £20, and 2 of £10; making a total of 2148 registered voters. Queen's county is included in the Home Circuit: the assizes are held at Maryborough; and general sessions of the peace at Maryborough, Mountmellick, Mountrath, Stradbally. Burros-in-Ossory, and Abbeyleix, twice in the year at each of these places. The county gaol is at Maryborough, and there are bridewells in Burros-in-Ossory, Stradbally, and Abbeyleix. The local government is vested in a lieutenant, 18 deputy-lieutenants, and 82 other magistrates; besides whom there are the usual county officers, including four coroners. There are 42 stations of the constabulary police, having a force of a sub-inspector, 9 chief officers, 45 sub-constables,291 men and 15 horses; besides which therc are three stations of the peace preservation police. The amount of the Grand Jury presentments, in 1835, was £21,575. 15. 1., of which £298. 16. 0. was for the roads, Bridges &c., of the county at large; £4124. 16. 0½. for those of the baronies; £9885. 15. 11 for public buildings, charities, officers' salaries, and incidents; £6680. 8. 2. for the police; and £541. 0. 4. for the repayment of advances made by Government. The district lunatic asylum for the Queen's and King's counties, Westmeath, and Longford, is at Mary. borough; as is also the county infirmary, and there are dispensaries at Abbeyleix, Ballybrittas, Ballymoyler, Ballinakill, Clondonagh, Errill, Mountrath, Mountmellick, Newtown, Coleraine, Portarlington, Rathdowney, Stradbally, Swan, Ballickmoyler, Burros-in-Ossory, and Clonaslee, which are supported by Grand Jury presentments and private subscriptions, in the proportion of one third of the former to two-thirds of the latter. In the military arrangements it is included in the eastern district, and contains one barrack for infantry at Maryborough, constructed for the reception of 61 non-commissioned officers and men.
The surface of the county is generally either flat or gently undulating with small hills, exhibiting a pleasing variety rather than picturesque effect. The inequality is mostly caused by the escars, ridges of which lraverse the county in several parts: they are mostly formed of rounded nodules of limestone, calcareous sandstone, and coal shale, the parent rocks of which are found in the county or close to its confines. The principal of these escars, called the Ridge, rises near Athlone and thence proceeding across the King's county, enters the Queen's at Mountmellick and proceeds to Rathleague through the extremity of Maryborough, forming in this county an unbroken line about 6 miles long, varying in height from 12 to 45 feet, being generally broad at the base and narrowing upwards to the width of a few feet; to the north of Maryborough a road is carried along its summit; south of the town it is planted. Near the same place a very copious spring bursts from it, called the Blessed well of Maryborough, and much resorted to by the peasantry, who perform devotional ceremonies, called stations, round it. Beyond Rathleague the escars maintain a southeastern course, and are broken and interrupted, but they soon resume a regular ridge-like form and divide into two branches, oue southwards to the Doon of Clopoke, the other eastwards to Stradbally, again forming an unbroken line of more than 6 miles. The tract extending from Urlingford, in Kilkenny county, to Dawson's Grove near Monastereven, on the confines of Kildare, is the most improved of any in Leinster. It is generally well planted, not in isolated patches close to the mansion-houses, but over the whole face of the landscape, so as to give it much the appearance of an English woodland scene. The Dysart hills, which are situated in this rich tract of country, add much to its variety and beauty; they are wholly composed of limestone, and their direction is north and south between the baronies of Maryborough, Stradbally, and Cullinagh, not forming a continuous elevation, but in most cases standing singly: the rock of Dunamase and the Doon of Clopoke are two of the most striking of them. To the west the land rises into the lofty range of the SlieveBloom mountains, which form a marked line of division between this and the King's county: their summit is called "the Height of Ireland," from a popular opinion that it is the most elevated point in the island; near it is the Pass of Glandine, a narrow defile, impassable for carriages, and forming the only mountain communication between the King's and Queen's counties. The northern side of the mountains of this range is very fertile, while the southern, though more exposed to the genial influence of the sun, is nearly barren and mostly covered with heath. Towards the southern boundary of the county the ground rises into the Slievemarigue hills, which separate it from Kilkenny. The only lake is that of Lough Aunagh, called also Lough Duff, on the border of the King's county, to which one-half of it is considered to belong.
The soil, which rests chiefly on a substratum of limestone, varies from a stiff clayey loam, well adapted to the growth of wheat, to a light sand, which, however, produces good barley, turnips and potatoes. In the Slieve-Bloom mountains the surface inclines to a black, and in some parts, a yellow clay, of unequal depth, covering a mouldering rock or gritty gravel; its general character is spongy, wet, boggy even where highest, and very rocky. The Dysart hills are fertile to their summits, which, though too steep for the plough, afford rich pasturage for sheep. The soil of the southern harony of Cullinagh is a gravelly silicious clay towards the mountains; in the central parts it is a rich loam, and in the south, light and sandy: the largest bullocks in the county are fattened on the rich pastures in the low lands. In the northern barony of Portnehinch the soil is light and unproductive, unless in some favoured spots where a persevering course of judicious cultivation has improved its character. Bogs are frequent in every part, chiefly about Maryborough; they may all be considered as branches of the great central bog of Allen. The turf from them yields both white and red ashes; that affording the latter is most esteemed either for manure or fuel. In some places are large tracts of marshy land called callows, which are inundated during winter but in summer afford excellent pasturage. The land on the banks of the Barrow is alluvial and forms rich and valuable meadows. The average size of farms, particularly in the tillage districts, is not more than from 12 to 14 acres; some noblemen and landed proprietors hold large tracts of land in their own hands, the superior cultivation of which is very effective as a leading example towards the general improvement of agriculture in the county. Wheat is now generally grown even in the mountain districts: barley is also extensively cultivated: potatoes and oats form an essential part of the rotation system. Green crops are often seen, particularly turnips, of which the Swedish is most esteemed: rape and vetches are extensively raised; clover is to be seen everywhere; flax is planted only in small quantities for domestic consumption. The implements and carriages employed in rural economy are generally of the most improved description: both bullocks and horses art: used in ploughing, generally in pairs: where the soil is very deep and stiff: two pairs of the latter are sometimes put in the same team. The manures are, lime and limestone gravel, here called com gravel, P,rocured with little labour or expense, and composts from the farm-yard. The common fence is of white thom planted on ditches well constructed but too often subsequently neglected: atone walls are also raised fur the same purpose, particularly for the demesnes of the nobility and gentry. All the improved breeds of English cattle have been introduced into the county. The most esteemed dairy cows are a cross between the Durham and native breed, as they are good milkers, of large size and easily fattened. Dairies are numerous and productive; cheese is made in small quantities; but butter, which is of very good quality, is the chief produce. Pigs are reared in very great numbers; no farm-house is without them, but the breed is inferior to that in the southem counties; goats are also kept by all the small farmers and cottiers. The horses are a light, small-boned, active race, good for the saddle but not well fitted for ho!avy agricultural labour.
A great part of the county, particularly the mountainous districts to the north-west, was once covered with timber, in proof of which it may be stated that in the neighbourhood of Lough Annagh, oak, fir and yew trees are found in numbers lying a few feet below the surface, some of the roots adhering to the trunks and others remaining in their original position, the trunks having been burnt off and the charred cinder adhering in all its fresbnesa to both trunk and root : large trunks and roots of trees are also perceptible in the lake, with their timber sound and remarkably tough. In the reign of Elizabeth, Capt. Leigh received the thanks of that queen for having valiantly led the English cavalry from Birr to Athy, through the woods and forests of Oregan. The country has since been entirely cleared of its old woods; but new plantations have sprung up in most parts. The farm-houses, like the farms, arc generally small; many have neat gardens and orcbards, which, with the hedgerow trees, give them the appearance of much rural comfort. Draining and irrigation are but little attended to.
The principal portion of the county belongs to the great Boetz limestone field, which forms the base of the greater part of the level country of Ireland; the Slieve-Bloom mountains in the north-west, are of the sandstone formation, and at the Slievemargue in the south-east the coal formation commences. The limestone field abounds with eacars, already noticed. The coal formation commences near Timahoe, and extends east and south-east to the Barrow, and southwards almost to the Nore. It forms the northern extremity of the Kilkenuy field, from which it is separated only by a small river, and the coal is in every respect similar in each part: the portion included in the Queen's county extends about 8 miles by~. The strata range as in Kilkenny, but the dip being to the west, the pits on this side are deeper. There are five collieries at work; namely, Newtown, Wolf Hill, Doonane, Poulakele and Moydebegh; those of Rushes and Tollerton, though very valuable, are not wrought at present. The pits at Newtown are from 45 to 48 yards deep, all those around Moydebegh are from 61 to 6i yards. The coal at Newtown and Doonane is equal to the best Kilkenny coal, and sells at 20,. per ton Ilt the pits; that of the other collieries, though somewhat inferior, never sinks below the price of 17s. per ton. Hence the poor people, even in the immediate vicinity of the pits, cannot afford to use it, and it is entirely purchased by maltsters, brewers, distillers and smiths, by whom it is much sought after, inasmuch as, being almost pure carbon, without any admixture of bitumen, it requires no preliIninary preparation even for malting purposes; it is conveyed to all the surrounding counties chiefly in one-horse carts. In the summer of 1836, 64 pits were at full work, for unwatering which five steam-engines were employed, hut the coal is mostly raised by horses. The works furnished employment to 700 men, and the valne of the coal raised is estimated at upwards of £78,000 per ann. Yet, notwithstanding these advantages, the workmen, from their irregular and inconsiderate habits, are miserably poor; and the district is frequently disturbed by broils and tumults, so that police stations are thickly distributed throughout this portion of the county. Iron ore shews itself in some parts, and minea were wrought until the failure of the IJ11pply of timber for fuel caused them to be relinquished: a branch of the iron-manufacture which had heen successfully carried on at Mountrath, when timber was plentiful, has been discontinued for the same reason. Copper aud mangauese have also been found. Slate quarries have been opened at Roundwood, in Offerlane, and at Cappard. Near Mountmellick are quarries of soft silicicus sandstone, which is wrought into chimney-pieces and hearth-stones that are in great demand. Ochre, fullers' earth, and potters' clay are met with. Potteries have been loug establisbed in the neighbourhood of Mountmellick, in which large quantities of tilt's, crocks, and garden pots are made.
The other manufactures are corifined to cottons, flannels, friezes and stuffs of a coarse durable kind for the clothing of the peasantry. Much broad cloth was woven in MountmeUick for the Dublin market, and a broad stuff called "Durants" was also manufactured there and at Maryborough; but the trade has long declined. The same observation is applicable to serges, the use of which has been in a great measure superseded by that of cotton cloth. Cotton factories were erected at Cullinagh, Abbeyleix, and on the Barrow near Atby, but all failed; the only one at present in the county is at Mountrath. In Mountmellick are an iron-foundry and extensive breweries, a distillery, and tanneries. At Donoughmore is a very extensive starchmanufactory, the produce of which is almost exclusively sent to Duolin, Flour-mills at Mountmenick, Coleraine, Maryborough, Castletown, Ratbdowney, Donoughmore, Abbeyleix and Stradbally, besides several in other parts, are each capable of manufacturing 12,000 barrels of flour annually.
The Nore is the only river of any magnitude that passes through the county: it rises in the Slieve-Bloom mountains and enters Kilkeuny near Durrow, receiving in this part of its course the Tonnet with its branch stream the Dolour, the Old Forge river, the Cloncoose with its branches the Cromoge and Corbally, the Trumry, the Colt, and the Erkin or Erkenny. The Barrow, which rises in the same mountain range, and forms the northern and part of the eastern boundary of the county, receives the Blackwater, the Trihogue, and the Owenass or Onas: it is navigable for barges from Athy downwards, and quits the county for that of Carlow at Cloghgrennan. The Grand Canal enters the county at Clogheen near Monastereven, and is carried along near its eastern boundary for eight miles to Blackford, where it re-enters the county of Kildare, and shortly after communicates with the Barrow at Athy. A branch baa been carried from Monastereven by Portarlington to Mountmellick. The roads are numerous throughout every part of the county: in general they are well laid out and kept in good order. The intended railway from Dublin to Kilkenny is to cross the Barrow from Kildare at Ardree below Athy, and will proceed by Milford, Grange, Shruel, and Graigue to Cloghgrennan, and proceed thence by Leighlin-Bridge to the city of Kilkenny.
Relics of antiquity of every description known in Ireland are to be found here. There is a pillar tower nearly perfect at Timahoe, in a valley near the ruins of a monastic building. On Kyle hill, about two miles from Burros-in-Ossory, is a rude seat of stone, called by the common people the Fairy Chair, which is supposed to have been an ancient judgment-seat of the Brehons. Near the south-western verge of the county is an ancient Irish fortress, called Baunaghraor" Kay's Strength," little known on account of its retired situation on the top of a high hill surrounded by a deep circular f08se with a mound or wall on the summit. The other principal relics are described under the heads of the parishes in which they are situated. Monastic institutions, of a very early date, were numerous, but most of them have 80 completely fallen into decay, that even their site cannot now be ascertained. The ruins of Aghaboe, whither the seat of the see of Ossory was removed from its original situation at Saiger, in the King's county, until its final removal to Kilkenny, still exist in such a state of preservation as to alford some idea of the extent and character of the buildings. The ruins of Aghmacart are also visible, as are traces of those of Killedelig, Killermogh, Mundrehid or Disert-Chuilin, and Teampul-na-Cailliagh-dubh, near Aghaboe. The churches of Dysartenos and Killabane have been preserved as parish churches. The site of the monastery of Leix is known only by the existence of the town of Abbeyleix: that of Timahoe is conjectured, with much probability, from the round tower there. Rostuirc was near the Slieve-Bloom mountains; Stradbally or Monaubealing stood near the town of Stradbally; Teagh-Schotin and Slatey were in Slievemargue: the sites of Cluainchaoin, Cluainimurchir, Disert Fularthaigh, Disert Odrain, Kilfoelain, and Leamchuil or Lahoil, are wholly unknown. Among the remains of military antiquities is the rock of Dunamase, described in the account of the parish of Dysartenos. Lea castle. on the Barrow, eight miles from Dunamase, is supposed to have been built about the same period, its architecture much resembling that of the other, and it was still further secured by its natural position, being protected on one side by the Barrow, and on the other by a deep morass: it was incapable, however, of holding out against Cromwell, by whom it was taken and destroyed. The castles of Shean, Moret, Ballymanus, and five others in the same part of the county, were built by Lord Mortimer, as posts of defence for the English tenants whom he endeavoured to settle on his estates. Shean or Sim castle was built on a conical hill: though not of great extent, it was a place of considerable strength, but not a vestige of it is now iu existence. Burros-in-Ossory was a strong fort on the Nore, belonging to the Fitzpatricks, and the great pass to Munster: it was the scene of a very bloody engagement in the war of 1641. Ballygihin, Castletown, Watercastle, and Castlefleming, with several others, belonged to branches of the same family. Shanbogh, in the same district, was a castellated mansion, which served as a protection against the rapparees who infested the deep woods with which this part of Ireland was then covered. Grantstown, Ballagh, Clonbyrne, Gortneclay, Coolkerry, and Kilbreedy are in the same barony. Castleculf in Tinnehinch, built about 1641, by Sir Charles Coote, celebrated for his military prowess, is a very large ruin: he also built the castle of Ruish-ball. The castles of Clara, Ballinakill, Coolamona, Tinnehinch, and Castlebrack, are in the same district: the last-named contains some subterraneous apartments, which were opened and partially explored, but presenting nothing more than other small caves, and the air being very foul, no attempt was made to penetrate to the extremity of any of them. The ruins of an old castle at Ballyadams, which gives name to the barony, are still visible; another is to be seen at Grange. Shrule castle was in the south-western extremity of the county, near the town of Carlow. The entrance into the ruins of Cloghgrennan castle separated the county of Carlow from the Queen's county. The remains of Rathaspeck castle were applied to the building of the neighbouring parish church. A conical heap of stones on the summit of a very lofty hill, near the boundary of Stradbally barony, is known by the name of Cobler's castle. The modern mansions of the nobility and gentry are noticed under the heads of their respective parishes.
The middle classes of the gentry pay much attention to the improvement and embellishment of their grounds; their dwelling-houses are handsome and convenient, with suitable offices. The habitations of the peasantry, though in many parts superior to those of the neighbouring counties, are very deficient in appearance or in internal comfort, Abbeyleix and Castletown are exceptions, much attention being paid to the houses there; in the baronies of Maryborough and Upper Ossory they are comfortable, but in the northern barony of Tiunehinch they are very poor, being little better than hovels, and in the neighbourhood of the collieries still worse. A plot of ground of from half an acre to an acre is generally attached to the peasant's hut, as a potato garden, for which he pays in labour from ~08. to 50 •. rent. The fuel throughout the entire county is turf, the coal being exclusi vely used for manufacturing purposes; wood was formerly so abundant, that a clause was introduced into many old leases binding the tenant to use no other kind of fuel; and at the present time the ancient custom of dues and services is inserted in many leases. A strong attachment to old customs is pointed out as one of the striking characteristics of the peasantry: but that this adherence is not caused by prejudice alone is proved by their adoption of improved practices of agriculture, when the success of others had ultimately convinced them of their superior advantages. Another fact, illustrative of this observation, is, that the peasantry in all parts, even in the mountainous districts, speak English fluently, the Irish being never heard except with some of the very old people. The custom of frequenting wells for devotional purposes is declining fast. Of the chalybeate springs the most remarkable are those at Cappard, Killeshin, MountmelIick, and Portarlington : the first· named is the strongest, but none of them are in much repute for their sanative qualities beyond their own immediate neighbourhood. There is a very singular artificial curiosity, called the Cut of Killeshin, about three miles from Carlow, on the road to the collieries. It is a pass through a lofty hill above half a mile long, and from 10 to 40 feet deep according to the rise of the ground, hut not more than four feet four inches wide, cut through the solid rock, so that cars have barely room to pass along it. The constant flow of water and the friction of the carriage wheels have occasioned this ex-traordinary excavation. The carrier, as he approached the gap at either end, shouted loudly, and the sound was easily conveyed to the other extremity through the cavity, Should the cars have met within the cut, the driver of the empty car was bound to back out, a task of no small difficulty along this narrow and ill-constructed road. A new road has been opened, which has obviated the necessity of making use of this pass. Contiguous to this cut are the ruins of Killeshin church, with an antique and highly ornamented entrance archway, surrounded by an inscription in Saxon characters, now illegible. Adjoining the church was a rath with a deep fosse. This place was remarkable for havilag once been the chief town in the county, though not a stone building of it is now standing except the ruins just mentioned.
Transcribed from A Topographical Dictionary of Ireland, 1840 by Samuel Lewis
Chapman code
The Chapman code for Queens County is LEX | eng | b05e3987-b7ad-40c4-8142-a85f61c6f1fa | https://ukga.org/index.php?pageid=29458 |
A Study of ACR-368 in Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma
Complete Title: ATrial Phase: I/II
Investigator: Petros Grivas`s OncoSignature® test status.
Keywords:
Endometrial Cancer
Ovarian Cancer
UrothelialPetros Grivas
RG1123312
NCT05548296
A | eng | 8b8696ac-a0d8-4b2b-b04b-ace45f488cf9 | https://www.fredhutch.org/en/research/clinical-trials/trial/a_study_of_acr-368_in_ovarian_carcinoma_endometrial_adenocarcino.html |
Ancestor Healing & Liberation
There are many factors to why we suffer and experience specific challenges in our lives. One is a result of our ancestors not being able to complete their karmic journey while in their human form.
November 1st at 12pm PST
By ❤️Donation
paypal.me/aravel | eng | 34e49995-56c5-4bc4-bd19-dc10b6b90c45 | https://www.skullwisdom.com/event-details/ancestor-healing-liberation |
5 Ways Public Policy Has Shaped the Justice System
5 WAYS PUBLIC POLICY HAS SHAPED THE JUSTICE SYSTEM Public policy has the potential to change the world. We've seen its widespread social and economic impacts in some of the most important stories of modern times: the passage of the Civil Rights Act, the Roe vs. Wade decision, the Homeland Security Act. All of these have had profound impacts on how our justice system works. Learn how public policy continues to shape our world, day in and day out. Sex Offender Management Example: Megan's Law New Jersey, 1995 A 7-year-old was raped and murdered by a man who lived on her block and who had been convicted of child molestation 2 times already Sex offender registration Lifetime supervision Community notification Longer incarceration times Community notification legislation that began in New Jersey was signed into a national law in May 1996 Updating Incarceration Standards II,I Redefining which offenses are punishable by prison Reacting to decreases in violent crime and proper- ty crime Example: sentence Assembly Bill 109 California, 2011 Shifted many corrections responsibilities from state to local governments Reaction to a U.S. Supreme Court ruling ordering the California Department of Corrections and Rehabilitation to reduce the state's prison occupancy by -33,000 prisoners Addressing immigrant incarceration issues Prisoner reentry and recidivism reduction programs Defining Fairness in Juvenile Justice Establishing education and rehabilitation in correctional facilities: Example: Statute for Student Records Transfer Vocational training 30% have been diag- nosed with a learning disability Academic training Nearly 1 in 2 incar- cerated juveniles function below grade level Louisiana, 2001 Prohibits school districts from withholding educational records of youth involved in the juvenile justice system Promoting collaboration between agencies: Reasons records were previously witheld: • Outstanding lunch money balances • Unreturned library books • Unpaid extracurricular activity fees Juvenile justice Child welfore Education system Smarter Drug Policies Systems to train judges and prosecutors in cases involving drugged drivers 1 in 8 nighttime drivers during the weekend are on illicit drugs Example: National Drug Control Strategy National, 2010 Defines addiction as a disease and emphasizes the need to pro- vide treatment to addicts involved in the criminal justice system Expanding the Court system 11 10 Someone is sent to drug treat- ment instead of prison every 2 in 3 juvenile offenders use drugs regularly 4 minutes Battling Hate Crime Example: >90,000 people have participated in Matthew Shepard and James Byrd, Jr., Hate Crimes Prevention Act "Tools for Tolerance" training National, 2009 Expands the definition of "hate crime" to include offenses motivated by: Creating a federal reposi- tory for information about hate crimes Disseminating law enforcement training about handling hate 45 states have statutes crimes against hate crime • Gender •Sexual orientation •Disability Are you ready to change the world? Learn how you can contribute by earning a Master of Public Administration from publicadmin.usc.edu. Sources: justice/mpri.html delinquent.org/nd/docs/NDTAC_PracticeGuide_IndividualSrves. pdf delinquent.org/nd/docs/NDTAC_PracticeGuide_InteragencyCommunication_2011.pdf driving html | eng | e53afe0e-15ef-4182-ad9d-e471a83d6675 | https://visual.ly/community/Infographics/politics/5-ways-public-policy-has-shaped-justice-system |
But I don't get why you want summon boat to be level 2 spell?
Imagine you get out from one-way telepoter on cursed ground,where you could summon a boat before(when the spell was 1st lvl)and now you are stuck thanks to this change.
____________
"I heard the latest HD version disables playing Heroes. Please reconsider."-Salamandre
Yes. Absolutely yes. But spells would need new icons, since most icons are aligned to the old school.
P.S. Did you know that the old version of Heroes III was supposed to have this system? I saw once a video of the Heroes III pre-alpha in youtube and it had the "Dark School" in Spellbook with MM6 Icons for spells.
This is not "system idea", rather the wishlist of spells. Ideas have some grounds and explanation, you know.
You need to explain, firts of all, WHY does this list make any sense. Then tell the details, for example how magic schools are learned and how they are distributed in the towns etc. If certain creatures are immune to certain schools. Are there any special abilities or artifacts that work with or against certain spells.
basically this is not a revolucionary idea, (about how spells are learned, etc...)
is more a idea for adding spells, and adding spells for delete the repeated in game, like "shield, magic arrow, etc...."
I like that both MIGHT and MAGIC heroes, are well separated, so to differentiate them better, and not catching a hero of MIGHT and teach only 4 schools (4/8 possible skills) and learn all spells of the game.
In my opinion, there are some skills, that never can be learned for a MAGIC hero (like, artilley, attack, armor, Warfare, Navigation, etc..)
some ideas
dark and light schools, dont need any expanation in the MM universe.
possibly, only can be learned with necromancers and clerics heroes respectively only.
and maybe, the other magic heroes of every town, can reach a basic on this schools. like MM8.
like all MM games, dark and light are the most powerful schools.
personally, i like the idea of a curative school, like MM6-8. instead of a only spells for this.
elemental schools, are the schools with more damage spells, to not repeat spells, i added some for every school.
-magic arrow only in earth, so have to create spark and fire arrow
-1 or 2 for area damage per school
-1 for a concentrated best damage per school (incinerate = implosion, for example)
and others.
in mind school, i have grouped, all "mind" related spells (berserk, forgetfulness, telekinesis), and added some damage spells.
spirit is personally the most discutible school, here are grouped, spells related to the spirit as well as those related to the "mother Nature".
about the affinity of schools with factions, i planned this.
probabilities for spells appearance in every faction: | eng | 005d31ef-740a-425b-874c-de6caa1ac242 | http://heroescommunity.com/viewthread.php3?TID=39835 |
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March 29, 2022
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The following article is intended to provide guidelines for choosing suitable marketing courses online for you. The listed marketing courses are best suited for small business owners who are looking to improve lead generation for their business or students looking to up-skill. We also share who we think are the top 5 free online marketing courses currently available in Australia.
Online marketing is not going anywhere anytime soon and it's a skill that constantly requires to be nurtured due to a constant changing environment.
Top 5 Marketing Courses Online in Australia for Beginners
Here is our top 5 pick of online marketing courses in Australia for 2022 that we highly recommend. They are fairly easy, free and great for beginners.
Learn the basics of digital marketing with Google's free Interactive Advertising Bureau-accredited course. There are 26 modules to learn from, all created by Google trainers and professionals, packed full of value and real-world application to help you get you started.
Learn inbound marketing which is a form of creating valuable content for your target audience that creates long term relationships. This course covers how to create content, nurture your leads and optimise the marketing process using automation strategies and AI tools.
Learn important skills and tactical know-how to develop and implement marketing strategies for your business. Discover the best online marketing practices using the latest marketing tools and how to advertise on social media.
This course will equip you with basic and practical digital marketing skills to help you build your business. It covers how to develop marketing strategies, create great content, how to develop your customer persona and conduct market research.
In this short course you will learn how to develop your digital marketing strategy and to leverage digital tools to achieve your marketing goals. It also includes modules on Social Network, SEO, SEM and a fantastic lesson about viral marketing.
Time to completion: 5 weeks
Difficulty Level: Beginner
Rating: 3.9
Which Marketing Courses Should I TakeHow Much Online Marketing Courses CostDo Online Marketing Courses Cover Social Media Platforms?
This is a great question to ask, and the answer is sometimes. We typically recommend courses that include this subject, but again it really depends on your target audience. As part of your marketing strategy, you should establish where your audience are hanging out and getting their information from. If they use social platforms, then definitely find a course that teaches about them.
For example, a target audience that is more career orientated may use LinkedIn and an artistic audience may prefer Pinterest. It's better to focus on 1 or 2 social platforms and really become an expert using them, rather than trying to learn about them all.
Are There Online Marketing Courses That Can Waste My Time?
This is a great question because frankly the internet is full of courses, and most of them are absolutely shit. Reviews and view counts are great to narrow down which courses can provide more value. It may also be beneficial to research the author/creator who developed the course and whether they have a good following, awards or credentials. Educational institutes or well-established brands usually develop great courses.
Not many people take this step before signing up for a course which can result in time being wasted. Always have a bit of a look at what the course offers, who created it, if they are still relevant, and if there are any available recommendations or reviews.
Don't struggle on your own. Get a second opinion on your digital marketing strategy (the first session is free). | eng | 00c9b174-aa9c-4456-b615-3e55ce844d1c | https://mindesigns.com.au/blog/marketing-courses-online/ |
Banning abortions because of down syndrome vs refusing organ transplants because of down syndrome
This year, Arizona and South Dakota passed laws banning abortions because of Down Syndrome. They did not, however, pass laws banning the denial of an organ transplant to people with Down Syndrome, which remains legal in both states.
Mississippi and North Dakota also banned abortion because of Down Syndrome—but still allow the denial of an organ transplant to people with Down Syndrome. It's almost as if protecting people with disabilities is not an actual legislative priority for the Republican Party. | eng | 8cd79a5a-bf47-4b67-890a-f933f46e427d | http://cococo.pbworks.com/w/page/145357233/Banning%20abortions%20because%20of%20down%20syndrome%20vs%20refusing%20organ%20transplants%20because%20of%20down%20syndrome |
Don't Understand Lyrics – Post Malone ...Read More
Don't Understand Lyrics
[Verse 1: Austin Richard] I'm a rolling stone I took you by surprise You hanging onto something, anything Just like a shimmer of light Oh, how the sorry felt I said, "You're really something, everything To me, and I'm cold So hold me closer, baby"
[Chorus: Austin Richard] I don't understand why you like me so much 'Cause I don't like myself I don't understand why you like me so much Wish I was someone else You say you got a million reasons But I can't think of one I don't understand why you like me so much 'Cause I don't like myself, mm-mm
[Verse 2: Austin Richard] I'll build a church for you They'll come from miles around 'Cause you're really somеthing, everything To me, and I'm cold So hold mе closer, baby
[Chorus: Austin Richard] I don't understand how you like me so much 'Cause I don't like myself I don't understand how you like me so much Wish I was someone else You say you got a million reasons But I can't think of one I don't understand how you like me so much 'Cause I don't like myself, mm-mm, mm-mm
Don't Understand Lyrics Meaning & Facts
[Verse 1] In the first verse, Post Malone describes himself as a "rolling stone," suggesting that he's constantly moving, changing, and perhaps struggling with feelings of restlessness and insecurity. He mentions taking someone by surprise, indicating that he might have entered into a relationship unexpectedly or without much thought. The lines "You hangin' onto something, anything / Just like a shimmer of light" could be interpreted as his partner clinging to hope or affection, even in difficult times, much like a faint glimmer of light in darkness.
The lines "Oh, how the sorry felt / I said, 'You're really something, everything / To me, and I'm cold / So hold me closer, baby'" express feelings of regret and inadequacy. He may have hurt his partner in some way, and while he acknowledges their significance in his life, he admits to feeling emotionally distant ("I'm cold") and seeks comfort and closeness from them.
[Chorus] The chorus is the heart of the song's emotional message. Post Malone expresses profound confusion and self-doubt regarding why his partner likes him so much. He confesses, "I don't like myself," indicating that he struggles with low self-esteem and self-worth. Despite their partner's affection, he cannot understand why they feel that way about him, and he wishes he could be someone else, presumably someone better or more deserving of love.
The lines "You say you got a million reasons / But I can't think of one" suggest that his partner has listed numerous positive attributes about him that make them love him, but he cannot see any of those qualities within himself. This disconnect between how he perceives himself and how his partner sees him deepens his feelings of confusion and inadequacy.
[Verse 2] In the second verse, Post Malone continues to express his devotion to his partner, declaring that he would go to great lengths to make them happy. He says, "I'll build a church for you / They'll come from miles around," which metaphorically signifies his willingness to create a sanctuary or a place of worship for their love. This imagery indicates that he values and reveres the love he shares with this person.
[Chorus] The second chorus reiterates the main themes of the song. Post Malone still can't comprehend why his partner loves him so much, reiterating his self-loathing with the lines "I don't like myself, mm-mm, mm-mm." The repetition emphasizes the depth of his internal struggle and his inability to reconcile the affection he receives with the negative perception he has of himself.
Overall, "Don't Understand" by Post Malone delves into themes of self-doubt, low self-esteem, and the struggle to accept love and affection from others when one doesn't feel deserving. The song showcases a vulnerable and introspective side of the artist, where he openly grapples with his own emotions and flaws. The track's emotive lyrics and soulful delivery contribute to its relatability and resonate with listeners who may have experienced similar feelings of self-doubt and uncertainty in their own relationships. | eng | 37558e09-0819-496f-a83c-83e05881fab2 | https://www.lyricsroll.com/dont-understand-lyrics-post-malone.html |
Causes And Significance Of The Battle Of Hastings
This is a huge advantage of homeschooling to have the flexibility to dive so deep into history. I am curious how this matter will be coated in our public faculty when the kids get to it. It was so fascinating and you may be proper it really might have gone both means. If it had it might have rewritten the historical past of Britain completely. I will have a wholly totally different post on the Bayeux Tapestry, which William's wife created for him to rejoice the battle.
Beginning at 9am on 14 October 1066 the battle lasted less than a day and is believed to have been over by dusk. But although this will likely seem brief by today's standards, on the time such battles have been typically over inside an hour. The system was based upon the idea that one of the best soldiers would be rewarded with a bit of land, making a bond of loyalty between the troops and their chief. In William's case, he took the land owned by Anglo-Saxon land and redistributed it to his Norman nobleman.
Hardrada invaded northern England in early September, main a fleet of more than 300 ships carrying perhaps 15,000 males. Hardrada's military was further augmented by the forces of Tostig, who supported the Norwegian king's bid for the throne. Advancing on York, the Norwegians occupied town after defeating a northern English military under Edwin and Morcar on 20 September on the Battle of Fulford. In 911, the Carolingian ruler Charles the Simple allowed a bunch of Vikings to settle in Normandy under their leader Rollo. Their settlement proved successful, and so they quickly adapted to the indigenous tradition, renouncing paganism, converting to Christianity, and intermarrying with the native population. In 1002, King Æthelred II married Emma, the sister of Richard II, Duke of Normandy.
According to some accounts he was struck within the eye by an arrow. With their chief dead, the English began to depart the battlefield. William of Normandy and Harald of Norway both stated that the throne had been promised to them. They every started making plans to invade England and fight King Harold.
Through The Norman takeover legislation, language and tradition all adapted. The Normans paved the finest way for the English feudal system, which might later be challenged with the Black Death and the Peasants Revolt. William I died in 1087, leaving his son, William Rufus, to become the successor of the throne as William II, making him the second Norman king of England.
Hardrada was ultimately defeated and killed in a surprise attack by Harold's forces within the Battle of Stamford Bridge on twenty fifth of September 1066. William's archers opened at close quarters but took heavy casualties from the English slings and spear assaults. Williams threw his cavalry in who took a mauling, panicked and ran for it. Crucially, this retreat managed to draw the English from their positions and turned the battle. Towards mid-afternoon, the English defence was low on numbers and exhausted and Harold's brothers, Gyrth and Leofwine have been both killed on the battlefield. As nightfall drew in, Harold, based on the Bayeux Tapestry, was killed by a Norman arrow by way of the eye though the talk about his ultimate demise rages on and on…
That assumes the Danish king needs to push his luck, considering Harold would have at this level defeated each the Norwegians and the Normans within a month. I would not say the Anglo-Saxon army Harold had was a completely skilled drive, however calling the fyrd rabble as if they cannot battle appears quite unfair. It reveals what the troopers may have seemed like when in battle, and also provides an excellent representation of what the Bishop and different religious leaders would have seemed like , and why. I was lucky enough to see this show "in the brick" at Bricktastic in Manchester just lately. The structure is a monster, with stark but spectacular terrain, and an exquisite assortment of minifigs arrayed in battle formation able to battle.
Harold stored the entire Housecarls who survived the massacre of Stamford Bridge, and gathered new fyrd models too. The English victory got here at nice cost, as Harold's army was left in a battered and weakened state. In 1071, chronicler William of Poitiers, a Norman soldier and chaplain of William the Conqueror, compiled the guide The Deeds of William, Duke of the Normans and King of England. The book particulars the marketing campaign of William the Conqueror in England. Battle Abbey's History Read an in-depth historical past of the abbey based by William the Conqueror after the Battle of Hastings, from its basis to its suppression and after. Find out much more about the occasions of 1066 and the impact of the Conquest, and discover spectacular Norman locations to go to throughout England. | eng | 02b6c296-753e-4bd1-9d38-96ea985439f9 | https://pairahanstudio.com/causes-and-significance-of-the-battle-of-hastings-2 |
THE COURSE AIMS TO OFFER THE THEORETICAL AND METHODOLOGICAL ELEMENTS TO ALLOW THE STUDENT TO DESIGN AND CONDUCT MOTOR ACTIVITIES ADAPTED TO THE (SPECIAL) NEEDS OF MOVEMENT OF SPECIFIC GROUPS (SUBJECTS IN DEVELOPMENTAL AGE, ADULT AND ELDERLY DISABLED, DISABLED, DISABLED) ENVIRONMENTAL) IN THE SOCIO-EDUCATIONAL FIELD.
Prerequisites
NOBODY
Contents
- THE NEEDS OF MOVEMENT IN THE DIFFERENT EARS OF LIFE (3H) - NATIONAL AND INTERNATIONAL SURVEILLANCE SYSTEMS FOR THE DETECTION OF THE HEALTH OF THE POPULATION: INDICATORS RELATING TO PHYSICAL ACTIVITY (2H) - APPROACHES FOR TEACHING AND MOTOR LEARNING (3H) - DESIGN AND TEACHING OF MOTOR ACTIVITIES IN THE PERIOD OF DEVELOPMENT AGE (2H) - TEACHING OF PHYSICAL-MOTOR AND SPORTS ACTIVITIES IN ADULT AGE. ELEMENTS OF DESIGN OF DIDACTIC-MOTOR PROPOSALS IN THE WORKING AND DOMESTIC SECTOR (3H) - GUIDELINES FOR THE DESIGN OF SPECIAL MOTOR ACTIVITIES (2H) - THE DESIGN AND TEACHING OF MOTOR ACTIVITIES FOR THE THIRD AGE. TOOLS FOR OBSERVATION AND MOTOR ASSESSMENT OF THE ELDERLY (3H) - TEACHING OF MOTOR ACTIVITIES FOR THE THIRD AGE: ACTIVE AGING AND FALL PREVENTION (2H) - TEACHING OF MOTOR AND SPORTS ACTIVITIES IN THE PRESENCE OF DISABILITIES (8H) - SPECIAL MOTOR ACTIVITY PROJECTS FOR DISABILITY, THIRD AGE AND VULNERABLE BANDS (5H) - THE ORGANIZATIONAL MODELS OF SPORT AND MOTOR ACTIVITIES FOR THE DISABLED: SPECIAL OLYMPICS (3H)
Teaching Methods
THE COURSE INCLUDES FRONTAL LESSONS WITH A TOTAL DURATION OF 36 HOURS (6 CFU) WITH THE AID OF SCREENINGS.
Verification of learning
THE ACHIEVEMENT OF THE OBJECTIVES OF THE COURSE IS CERTIFIED BY PASSING AN EXAM WITH EXPRESS EVALUATION IN THIRTIES. THE TEST, WITH A DURATION NOT EXCEEDING 20 MINUTES, IS AIMED TO ENSURE: - THE LEVEL OF KNOWLEDGE OF THEORETICAL CONTENT; - THE ABILITY TO APPLY THE KNOWLEDGE ACQUIRED THROUGH THE PRESENTATION OF A PROJECT - THE LEVEL OF COMPETENCE ACHIEVED WITH RESPECT TO: LANGUAGE PROPERTIES, LOGICAL-DEDUCTIVE AND SYNTHESIS SKILLS, ARGUMENTATION SKILLS, AUTONOMY OF JUDGMENT. | eng | 38b17ca2-7b7c-43f9-a0ec-faa8ef38d24e | https://corsi.unisa.it/44222/en/teaching/course-units?anno=2022&id=506938 |
Tag: give it
Whatever you're looking for in life, give it away. If you're looking for peace, give peace. If you're looking for joy, give joy. It's in the giving, that you create it. It's in giving it away that you show how abundant you are with it already. | eng | 983938c2-c28f-4a74-bd3d-3e605490683d | https://foxmichaels.com/tag/give-it/ |
Gumtree used cars | eng | cb418e6b-a796-48de-a139-70a50781cb7e | https://www.benzinsider.com/tag/gumtree-used-cars/ |
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Egypt, to bring us to this wretched place?" – Numbers 20:1-5 (NRSV, abridged)
They don't ask, "Where can we find water?"
They don't ask, "How can we source enough water for our people and our livestock?"
They ask, "Why are we here?"
A question of purpose overtakes the need for outcomes. Their desperation for action shows up as a question of meaning.
"Why?" can be a discouraging question, the kind that spins relentlessly and consumes the soul for lack of an answer. "Why?" can also be an uplifting question, the kind that invites aspiration and the invigoration of a good soul-searching. "Why?" is rarely a neutral question. Even the innocent curiosity of "Why?" lends itself to judgment. (Answer a child's "Why?" with "Because." and see if the questioner is satisfied. Or explain why the sky is blue and notice whether awe is sparked or deflated.)
"Why?" is a question by which we can be lost or found, drawn close or cast into the wild.
God doesn't answer the people's "Why?" Neither does Moses. Neither does Aaron. Instead, the unasked question of "How?" is answered, with Moses striking a rock until water pours out of it. The action of how draws the people to a wellspring of holy relief. The how demonstrates God's why.
The people's "Why?" isn't answered, but in God's why, they are comforted.
Prayer: For every question I ask and every answer I seek, O God, show me your love.
Moses said to the people, "Remember this day on which you came out of Egypt, out of the house of slavery; no leavened bread shall be eaten. Today, in the month of Abib, you are going out. When the [Sovereign] brings you into a land flowing with milk and honey, you shall keep this observance in this month." – Exodus 13:3-5 (NRSV, abridged)
The ancient Israelites resided in Egypt for four hundred thirty years (Exodus 12:40). That's four hundred thirty years of separation from their ancestral home. Four hundred thirty years of agony and violence. Four hundred thirty years of bearing down through the pain just to survive. Four hundred thirty years of generational trauma.
Four hundred thirty years that could not be "fixed" in one day.
And yet on that day when Pharaoh said "Go!" and the people fled Egypt, Moses instructed them, "Remember this day." Remember this one day in this one particular month. Remember this day when healing began. Remember this day when freedom started its journey. Remember this one day when the food tasted different, when time seemed to stand still, when new possibilities broke open before you.
Remember the beginning.
When the land is dry and your tongue cries out for milk. When your feet are weary and your skin thirsts for oil. When your soul imagines a bitter end and your heart does not remember the taste of honey.
Remember the beginning.
At the beginning, God strengthened you against fear and doubt, despite all the hardships you had known. You had every reason to avoid risk, to stay with the familiar, but God drew you out into the beautiful unknown. Even when the unknown is overwhelming, even when trouble finds you, you will remember the story of what is possible.
And when you reach the end in all its satisfaction, remember and celebrate the beginning through which God brought you here.
Prayer: When I forget the story, O God, tell it to me again from the beginning.. -...
- | eng | bf75087c-574a-4658-9cea-e52e062f95d5 | https://rachelhackenberg.com/blog/ |
Tropical Rainbow is such a fun glitter dip, perfect for summer. It's a mix of different size and color glitters, the main background color is a golden yellow. You can also see all the color of the rainbow, depending on how light shines on it, shades of redi-ish auburn orange, green, blue and don't forget there is purple too! To achieve better coverage, "lay" fingernail flat on the dip powder. To get a smoother application, flatten the glitter with your finger using a baggie each time you apply a layer. | eng | 96ed8636-b70d-438d-9047-bea79874f0f9 | https://adradadippowder.com/tropical-rainbow/ |
Essays
Jayne and I believe whole heartedly in the Reader's Bill of Rights excerpted from the 1999 book by Daniel Pennac, Better Than Life. 1. The right not to read. 2. The right to skip pages. 3. The right to not finish. 4. The right to reread. 5. The right | eng | b45b0d86-8350-4308-8851-6bbca1cf5b6e | https://dearauthor.com/category/features/essays/page/17/ |
5 ways to celebrate Earth Day in Auburn this year
If you haven't already heard, Thursday, April 22nd is Earth Day! What better way to get out there and show your support for environmental protection than immersing yourself in your town's local parks and nature? We picked out 5 fun ways to celebrate Earth Day in Auburn & Opelika this year.
1. Kiesel Park
Kiesel Park. Photos via Emilyn Hamn for the Bama Buzz
Kiesel Park is not just your average park. There is a beautiful shaded pavilion, a large pond full of life, fields and fields of grass, and a 2.25 mile walking trail. Bring your pets and explore every corner of this cool park—but keep a vigilant eye out for snakes!
Address: 520 Chadwick Lane, Auburn AL 36832
2. Salem-Shotwell Covered Bridge
The Salem-Shotwell Bridge was originally built in 1900 to connect Salem and Shotwell, but a tragic accident with a fallen tree destroyed the bridge. However, the bridge was rebuilt in 2007 by the Lee County Historical Society and the Opelika Kiwanis Club. Now, visitors can walk over the bridge and explore the grounds behind it. We recommend walking through the Caroline Dean Wild Flower Trail for a beautiful experience with nature.
Address: Park Road, Opelika AL 36801
3. Kreher Preserve & Nature Center
Just a short drive from downtown Auburn, the Kreher Preserve & Nature Center is the perfect place to visit in honor of Earth Day. Their mission is to promote a sense of stewardship towards nature through quality environmental education, recreation, and outreach programs with Auburn and its community. If that doesn't scream Earth Day in Auburn, I don't know what does! They have 120 acres of land, six miles of hiking trails, and a nature playground to enjoy.
Address: North College Street, Auburn AL 36830
4. The Red Barn
The Red Barn. Photo via Emilyn Hamn for the Bama Buzz
The Red Barn at the Agricultural Heritage Park is definitely an Auburn favorite. Located right off of Auburn's campus, you can be sure to find students relaxing here on any sunny day. Throw the ball with your dog, take a picnic, or just take in the sunshine here. This is one of my go-to spots to take friends, and a great place to get outside and celebrate our beautiful Earth.
5. Chewacla State Park
Chewacla State Park. Photos via Emilyn Hamn for the Bama Buzz
Auburn is proud to be home to our very own Chewacla State Park. For only 4 dollars per adult, you can have full access to all that these 696 acres have to offer. With hiking trails, a huge lake for fishing, a waterfall, mountain biking, and camp grounds, there is something exciting for everyone to do. This would truly be high up on my list of ways to celebrate Earth Day!
Address: 124 Shell Toomer Parkway, Auburn AL 36830
Getting outside and enjoying nature with friends and family has become especially important this past year. I can tell that this Earth Day is going to be good one with everyone wanting to spend time with loved ones outside. These options are a guaranteed good time, and you are sure to feel closer to nature after visiting.
Did we miss a way to celebrate Earth Day in Auburn? Please let us know by tagging @TheBamaBuzz on social media and be sure to follow us to see more stories like this! | eng | 27c729f9-111a-4085-9b57-a4d8bef8545b | https://thebamabuzz.com/5-ways-to-celebrate-earth-day-in-auburn-this-year/ |
Sycamore Centre October 2022
The children had a fantastic time at the Sycamore Centre in Dudley. There were loads of activities to explore and at the end of the afternoon the children made popcorn on a campfire. This linked in well to the poem 'Popcorn', that the class had learned as part of Poetry week which was the week before the trip. The children said the poem as the popcorn cooked! Enjoy looking through the photographs | eng | 1e6507b2-f24d-4d29-907a-04ff34aa68d8 | https://www.moorcroftwood.net/sycamore-centre-october-2022/ |
In This Article
Only one type of soil particle can be seen by the naked eye, and that's a sand particle. If you have to get out a microscope to see it, it's either silt or clay, and there you have it: The three types of soil particles, from largest to smallest, are sand, silt, and clay. And you can't view clay with a standard microscope; rather, you need an electron microscope for this tiniest soil particle.
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The ratio of the various particulates in a soil defines that soil's texture, one of the many soil properties. This is important because any successful gardening effort depends on the texture of the soil, which has a bearing on what can be grown there and what amendments could be added to improve its texture.
Video of the Day
The Three Types of Soil Particles: Soil Texture
Soil texture is defined by its ratio of sand, silt, and clay. A common word used to describe a well-textured soil is "loam." If considered to be loam, a soil has a proportion of sand, silt, and clay that will generally support any plant. A soil might also be called "silt loam" if it contains no more than 50 percent sand and 27 percent clay, while the balance is silt.
Some experts also recognize gravel as an additional soil particle. If you do have substantial gravel in your soil, it will feel rocky and rough. To visualize the size of these various particles, consider this: If a particle of clay were the size of a marble, a silt particle would be the size of a golf ball and a sand particle the size of a baseball. If gravel were also present, it would be the size of a basketball.
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Soil Texture in Your Garden
Soil texture is the foundation of any garden or landscape. If the texture isn't conducive to the plants you want to grow, you can try to amend it with appropriate materials to create a more loamy soil — although there's a reasonable limit to how effective this is if your soil is mostly clay or sand at the two ends of the spectrum.
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If your soil is the right mixture of sand, silt, and clay, it will be a loam that holds water but still drains well so your plants don't grow in standing water. A sandy soil can't hold moisture because the water just runs down and out of the soil. A clayish soil has such fine particles with so little space between them that there's little opportunity for water to pass through and out.
A clayish soil can benefit from the addition of sawdust, leaf mold, manure, compost, or peat moss. A too-sandy soil can be improved primarily with compost and other organic materials that can provide nutrients to your plants.
Determining the Texture of Your Soil
If you dig in your garden and come up with a shovelful of compacted soil that retains its shape when you drop it on the ground, your soil is clayish. A loamy soil with a good texture balance will break apart into smaller clumps, while a sandy soil won't hold its form at all.
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You can try the finger-test also: Attempt to form a ball with a clump of soil. A sandy soil won't form a ball, while a loamy soil will. To identify a loamy soil versus a clayish soil, try to form a ribbon of about 2 inches in length with a clump of soil pushed between your thumb and forefinger. If the soil is clayish, you'll be able to squeeze it into about a 2-inch-long ribbon, but a loamy soil has too much air in its texture to allow that.
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If you want a more accurate analysis of your soil texture, you can send it to a lab for a specific breakdown of the percentages of soil particle types, called a "mechanical analysis." These tests measure the amount of time it takes soil particles to drop to the bottom of a cylinder filled with water. These percentages reveal the specific soil texture.
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Hunker may earn compensation through affiliate links in this story. Learn more about our affiliate and product review process here. | eng | f1860f87-2570-4e88-b8df-ee63a571e7ce | https://www.hunker.com/12397007/3-types-of-soil-particles-sized-from-biggest-to-smallest |
Pelican
A pelican, derived from the Greek word pelekys (meaning "axe"
and applied to birds that cut wood with their bills or beaks)
is a large water bird with a large throat pouch, belonging
to the bird family Pelecanidae.
Modern pelicans, of which there are eight species, are found
on all continents except Antarctica. They primarily inhabit
warm regions.
Overview of the Pelican
Overview of the Pelican
A pelican is a water bird with a large throat pouch.
There are eight species of pelicans, which are found
on all continents except Antarctica. The smallest species
is the Brow Pelican, which can weigh as little as 6
pounds, with a wingspan of 6 feet. The largest is the
Dalmation Pelican, which can weigh up to 33 pounds,
with a wingspans of 10 feet. The Australian Pelican
has the longest bill of any bird.
Pelicans swim very well, using their strong legs and
webbed feet (a feature in all birds classified as pelicans).
Pelicans eat mostly fish, but will also eat amphibians,
crustaceans, and very rarely, other birds. They catch
fish by expanding their throat pouch. They then must
drain it for about a minute before they can swallow.
Young pelicans are fed by their parents large amounts.
Scientists have observed that before or especially after
being fed, pelican chicks may seem to have a seizure
that ends with them falling unconscious. The reason
for this is not clearly known.
The Dalmatian Pelican and the Spot-billed Pelican are
the rarest species of pelican, with an estimated population
of 10,000 to 20,000 and 13,000 to 18,000 respectively.
The most common is believed to be the Australian Pelican,
with an estimated population of 400,000. However, the
White Pelican or Brown Pelican are close competitors
in population size. | eng | ffae4567-632a-47c8-88e8-6b4cd2d72473 | http://wildlife-animals.com/pelican/overview-of-the-pelican.php |
How Confidence Is Different than Self- Esteem And Why It Matters
The link below is a blog post from Z Girls which is a blog about empowering girls in sports. This article in particular however, can be applied across genders, is relevant beyond sports and provides a brief overview of the difference between confidence and self-esteem and why both are important. Food for thought… | eng | 29539207-72ec-4f18-9344-851c7e523f73 | https://northstarmontessori.ca/how-confidence-is-different-than-self-esteem-and-why-it-matters/ |
Learning Outcomes :- This assessment addresses the following learning outcomes: 1. Integrate and apply their knowledge and skills in public health 2. Apply research skills to a public health issue 3. Analyse the results of data collected from research taking into consideration prior evidence and theory 4. Understand the ethical implications for conducting a piece of public health research 5.Present the results of findings to peers and seek feedback 6.Collaborate with other students in a small team environment in order to progress their research
Instructions: For this assignment students will present the findings of their research via Power point Collaborate Zoom. Other students will be invited to feedback on the findings of this research. Presentations will be 15 minutes. Presentation format may follow the format of the final research report, 1. Summary/Abstract 2. Introduction 3. Research design and methods 4. Results 5. Analysis
Assessment Criteria: 1. Clearly communicates the research purpose justification methods results and analysis 2. Adapts the presentation for the specific audience 3. Presentation is well structured and easy to understand, with logical flow across sections 4. Presentation maintains interest of the audience, via creative delivery use of presentation aids eye contact emphasis on key points of interest 5. Demonstrated interpretation of findings in light of previous research/theory 6.Presentation stimulates debate among audience 7.Presentation keeps to time allocated 8.Student provides constructive critical feedback on other students' presentations
ORDER This PUBH6012 Capstone B Applied Research Project In Public Health | eng | c4dfe108-32a7-403e-9f1e-feedb2ff9d38 | https://assignmenthelpinaustralia.com/pubh6012-capstone-b-applied-research-project-in-public-health-assignment |
Abstract
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N2AB | eng | 551aa02a-26f9-45cc-8806-9aaee7d643ce | https://research.monash.edu/en/publications/schwann-cells-cultured-from-adult-rats-contain-a-cytoskeletal-pro |
Holy in Different Languages
"Holy" is a word that describes something very special and sacred, often connected to religion. It's used to show deep respect or reverence for things like places, texts, or people that are considered spiritually pure or divine. People use it to express the idea that something is deeply meaningful and important | eng | 67ff12b0-a7d7-4a8a-9f59-8db0c73f2e8a | https://thedifferentlanguages.com/how-to-say-holy/ |
You Have Completed the Course and Received a Certificate
You have completed the course and received a certificate, but you lost it on the way back. Write a letter to the Principal of the college; In your letter, you should tell:
How you lost the certificate?
Why do you need it?
What do you expect the principal to do?
Dear Principal,
I am writing to inform you that I have unfortunately lost my certificate on my way back from the college after completing the course. I had carefully packed the certificate in my bag, but I must have misplaced it during my journey home.
I am writing to request a replacement certificate as soon as possible. The certificate is important to me as it is proof of my successful completion of the course, and it is required for several job applications that I have been pursuing. The loss of the certificate has caused me great distress and inconvenience, and I would greatly appreciate any help you can provide in this matter.
I would like to request that you issue me a new certificate as soon as possible. I understand that this may require some administrative work and may incur additional costs, and I am willing to cover any associated fees. I would also appreciate it if you could provide me with any relevant information or documents required to obtain the replacement certificate.
I have always been grateful for the quality education that your college has provided, and I hope that you can help me resolve this matter soon. I would be happy to provide any further information or documentation required to facilitate the issuance of a new certificate.
Thank you for your understanding and assistance in this matter.
Sincerely,
Brock
Sample 2 You Have Completed the Course and Received a Certificate
Dear Principal,
I am writing to inform you that I have unfortunately lost the certificate that I received upon completing the course at your esteemed college. Unfortunately, I lost the certificate while traveling back home from the college.
The certificate is of great importance to me as it serves as proof of my successful completion of the course. I need it to apply for jobs and other educational opportunities. Losing the certificate has caused me great distress and inconvenience, and I am eager to obtain a replacement certificate as soon as possible.
I am writing to request your assistance in this matter. I am hoping that the college has a record of my completion of the course and that it would be possible to issue a duplicate certificate. If necessary, I am willing to provide any documents or information that would help facilitate this process. I am also willing to pay any associated fees that come with issuing a replacement certificate.
As a student of your college, I have always appreciated the quality of education and support that the college has provided. I hope that you can help me resolve this matter quickly and efficiently. I look forward to hearing from you soon. | eng | 9074a28d-1f63-457d-acff-e30a8027b8b3 | https://ielts-fever.com/you-have-completed-the-course-and-received-a-certificate/ |
Genetics news & views from students enrolled in BIOL 2110 at Stockton University.
Saturday, October 24, 2020
TARR5 mutation discovery
In "People with this mutation can't smell stinky fish" by Katherine J. Wu, she talks about a new genetic trait that is appearing in Iceland citizens. Though the gene is very rare, it still has been seen throughout the country. The mutation makes it so that people with it can't smell unfresh fish, unlike many people. Like many genes, the gene develops over time and takes a while to spread to others. The reason that the mutation had occurred was due to a change in the TARR5 strand.
I believe that genetic coding does help understand why there might be a change in a gene in a population and that we should understand what the strands could change. Each genetic code has a different job; some can change causing mutations within an area over time. | eng | 5c8fff26-7ec6-418b-84f5-78f59593354b | https://www.punnettssquare.com/2020/10/tarr5-mutation-discovery.html |
In this course, students will learn about the different types of updates that Microsoft provides for Windows 10. They will learn what the Windows 10 May 2019 Update is, what it includes, and how to obtain it. Additionally, they will become familiar with the lock screen, the various options that the sign-in screen provides, and how to sign in to a Windows 10 account.
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Your email address will not be published. Required fields are marked * | eng | c1298c79-d718-4ff1-9e31-66eba6a98cf2 | https://a2ze-learn.com/shop/windows-10-may-2019-update-getting-started/ |
5 Former Bullies Explain How to Stop Bullying
Sadly, bullying occurs far too often in schools, online, and behind closed doors at home. Bullies usually have low self-esteem or abusive home environments and take out their pain on others. They need help and support to overcome their emotional struggles and deserve compassion like everyone else. However, their behavior can inflict severe psychological and physical harm on others.
According to US Department of Health and Human Services research, around 20% of students aged 12-18 experienced bullying in 2019. Most students encountered bullying during school, but 15% also admitted to being bullied online. The most common types of bullying they reported included being the subject of rumors, being insulted or ridiculed, and being pushed or shoved.
Bullies usually don't realize how their behavior affects others until later. Many of them feel remorse about hurting people and apologize to their classmates. Some even become friends with the peers they bullied after they've reconciled and gained perspective on their past. Below, we'll share a few stories posted on Reddit from former bullies who explained how they transformed into kind, empathetic individuals.
5 Former Bullies Explain What Inspired Them to Change
1 – Bullying Perpetuates Isolation
Bullying creates a wall between you and others. Compassion and understanding break down those walls.
"Right after high school was the turning point for me…I was having a lot of discord with my own friends due to my attitude and it took hearing their honest feedback about how my approach was alienating them for me to start doing major self reflection. I decided I didn't want people to fear me and I certainly didn't want to alienate my own friends, so I started talking less and listening more.
I made an honest effort to care more about people as individuals-I got interested in the unique strengths each person brings to the table and did what I could to start learning from others. I humbled myself a lot over the years. I worked on saying I'm sorry and admitting when I was wrong. And years later I've gotten into therapy to continue to work on myself. I'll never be warm and fuzzy as that's just not my personality, but I'm a much better person than I was when I was younger." — @Babhak
2 – Bullies Operate From a Place of Negative Thinking
Bullying might make you feel physically stronger, but the negativity affects you subconsciously. Kindness feels much better in the end.
"I was one of those jocks who picks on the weaker kids who couldn't really defend themselves, in order to make the crowd laugh…it was never anything too physical or over the top, so parents or others never got involved, but I know that I made life a pain for some individuals while in elementary school.
Anyhow, this PE teacher of mine took me into his office after hours one day and explained that I should try to use my authority better, and that while it might feel good to make others laugh on someone else's behalf, it feels a lot better to be an overall good guy.
Never really had any good male influence in my life before that, so that really stuck with me, and from high school and onward I tried to reach out and confront others in school that bullied others. Oftentimes we just don't know better." — @KingBob3922
3 – Trauma Causes Bullying
Sometimes, bullies act out because of childhood trauma. Meeting the right person or mentor can give them wisdom and direction in life.
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"I grew up in an abusive home and did it out of self-protection. Verbally hurt them before they could hurt you. I know my behavior didn't make me popular or really make me feel better but I needed to lash out on the easiest targets. fast forward to having no friends in my mid 20 s and needed to figure out why.
I actually became friends with older coworkers [and] as a proxy parental influence they gently guided me. 'Why would you say that to someone? Why would you say that about yourself? Why do you talk that way? Why is everything a fight? What's wrong with being different? What's wrong with making mistakes?' No judgments, just gentle questions that I couldn't answer until I looked hard at myself.
4 – Bullies Can Change With Support and Encouragement
Shaming and bullying people comes back to bite you eventually. But, a simple apology can heal old wounds and encourage a fresh start.
"On the first day of 8th grade I noticed a new kid in school, and for whatever reason I bullied him, called him short, fat, ugly, whatever I could think of to get under his skin. It got old after a while and it came to and end, but he never held a grudge. Come freshman year we're on the same football team and I could barely stand to be in the same room with him I was so ashamed. I mustered up some courage and apologized. He invited me to hangout after school that day. Turns out we had a lot in common and came from very similar families. We've been like brothers ever since, I'll be the best man at his wedding in September. — @eNcore33
5 -Bullies Learn the Behavior in the Home
Bullying usually starts at home since children mimic their parents' behaviors. It takes a lot of self-reflection to unlearn these destructive patterns at a young age.
"When I was still quite young ( early teens ) I realised I was modelling my behaviour on one of my parents, and that they were a very obvious bully. Took immediate steps to re-define myself as a person who carefully avoided that abusive tendency." — @FunkerSpelunker
Final Thoughts on Stories From Former Bullies
Bullying affects everyone involved, including the instigator of the hurtful behaviors. Many bullies have turbulent home lives and take out their pain and frustrations on classmates. Childhood trauma doesn't excuse their behavior but explains why they act out at school. However, many people who engage in bullying feel deep regret and shame years down the road. Some of them reach out to their victims and apologize for how they treated them.
Bullies are not bad people. Instead, they often had to deal with a challenging hand. However, after years of humbling life lessons, many former bullies change for the better and learn to treat others compassionately together | eng | 5ffce104-c33a-4d51-b05c-aa49dc8bbf83 | https://www.powerofpositivity.com/bullies-explain-how-stop-bullying/ |
Introduction: Why Chickens Go Off the Lay
Egg-laying is an essential aspect of chicken farming. However, sometimes hens may stop laying eggs, causing losses to farmers. Chickens can go off the lay for various reasons, including age-related factors, environmental causes, nutritional issues, genetic factors, and health problems. It is vital to identify the cause of decreased egg production to take appropriate measures to remedy the situation.
Age-Related Factors in Egg Production
As chickens age, their egg-laying capacity decreases. Hens usually start laying eggs at six months and continue for about two years. After that, the number of eggs laid decreases gradually. At about three years, egg production declines significantly, and some hens stop laying altogether. However, while age significantly affects egg production, it is not the only factor. Some hens may continue laying eggs well into their senior years, provided they receive good care and nutrition.
Environmental Causes of Decreased Laying
Environmental factors may also cause chickens to go off the lay. For instance, inadequate lighting or inconsistent lighting can cause hens to stop laying or lay fewer eggs. Inappropriate temperature and humidity levels in the coop or run can also affect egg production. Additionally, dirty, overcrowded, or poorly ventilated coops can cause stress, leading to decreased egg production.
Nutritional Issues That Affect Egg Production
A well-balanced diet is essential for chickens to produce eggs. Feeding chickens with inadequate or imbalanced diets can lead to decreased egg production. Chickens require protein, carbohydrates, fats, minerals, and vitamins to lay eggs. Lack of calcium in the diet can lead to soft-shelled or shell-less eggs, while a deficiency in vitamins A, D, E, and K can cause a decrease in egg production.
Health Problems That Decrease Egg Laying
Various health problems can cause chickens to go off the lay. Infectious diseases, such as avian influenza, and parasitic infections, such as mites and lice, can cause stress, leading to decreased egg production. Other illnesses, such as respiratory infections or egg yolk peritonitis, can also affect a hen's egg-laying capacity. It is essential to monitor the flock's health and seek veterinary care when necessary.
Genetics and Laying Capacity in Chickens
Different chicken breeds have varying egg-laying capacities. Some breeds, such as Leghorns, are known for their high egg production. On the other hand, other breeds, such as Silkies, have a lower egg-laying capacity. Age and genetics also play a significant role in egg production. Some hens may lay fewer eggs due to inherited traits.
Seasonal Effects on Egg Production
Egg production can also be affected by seasonal changes. In the winter, shorter days and colder temperatures can affect egg production. On the other hand, in the summer, hot temperatures can cause stress, leading to decreased egg production. Some farmers may use artificial lighting to stimulate egg production during the darker winter months.
Stress and its Impact on Egg Laying
Chickens are sensitive to stress, and various factors can cause stress in chickens. For instance, overcrowding, noisy environments, and sudden changes in routine can stress chickens. Stress can lead to decreased egg production or even stop egg-laying altogether.
Broodiness and its Impact on Egg Production
Broodiness is a natural behavior in hens that involves sitting on eggs to hatch them. However, broodiness can cause decreased egg production as the hen stops laying eggs. Some chicken breeds are more prone to broodiness than others. Farmers can use various techniques to manage broodiness, such as separating broody hens or providing nesting boxes that discourage broodiness.
Common Management Practices That Affect Egg Laying
Several management practices can affect egg production. For instance, regular cleaning of coops and runs can prevent the spread of disease and reduce stress. Providing adequate lighting and ventilation can also enhance egg production. Proper nutrition and access to clean water are essential for good egg production. Finally, regular monitoring of the flock's health and welfare can prevent or address issues that may affect egg-laying. | eng | e46ae70f-f234-4d65-a9aa-f471a1d1a6bb | https://pettime.net/what-causes-chickens-to-go-off-the-lay/ |
Sections
Mulching for a Healthy Landscape
Rating
(15 votes):
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For as long as trees have grown in forests, leaves and needles have fallen to the ground and formed a natural protective layer over the soil. This same protection can be given to the plants in our landscapes by mulching. | eng | 251bd3af-cadb-48a7-861e-6644120b46dd | http://forestryindex.net/links/mulching-for-a-healthy-landscape/view?searchterm=None |
Vendors in these markets provide detailed descriptions of their products including quality, quantity, source and any additional personal details available about the victim - this makes it easier for potential buyers who are looking for particular combinations or credentials.
It's alarming to see that cybercriminals are increasingly utilizing dark web marketplaces as a platform for selling stolen information.
These marketplaces offer anonymity to both sellers and buyers, making it challenging for law enforcement agencies to track them down.
Cryptocurrency such as Bitcoin is usually used by vendors which is untraceable
The prices vary depending on factors like type of data being sold (e.g., credit card numbers vs medical records), amount available etcetera.
Some Interesting Opinions
1. Data breaches will become a thing of the past by 2025.
With the rise of AI-powered security systems, the number of data breaches will decrease by 90% in the next two years.
2. Companies that experience data breaches should be held criminally liable.
According to a recent survey, 80% of consumers believe that companies should be held criminally liable for data breaches that result in the loss of personal information.
3. The use of biometric data will eliminate the need for passwords.
By 2023, 80% of companies will have implemented biometric authentication methods, eliminating the need for passwords and reducing the risk of data breaches.
4. Hackers will become obsolete due to advancements in AI-powered cybersecurity.
With the rise of AI-powered cybersecurity, hackers will become obsolete by 2025, as AI systems will be able to detect and prevent attacks before they occur.
5. The government should have access to all personal data to prevent terrorism.
According to a recent survey, 60% of Americans believe that the government should have access to all personal data to prevent terrorism, even if it means sacrificing privacy.
Increase In Ransomware Attacks
Protecting Against Ransomware Attacks
As a cybersecurity expert, I am deeply concerned about the rise of ransomware attacks affecting organizations worldwide.
In 2023, we witnessed an unprecedented surge in these types of cyberattacks as criminals become more sophisticated and creative with their tactics.
No one is safe from these threats - individuals, small businesses, large enterprises, government bodies, and hospitals are all potential targets.
Phishing emails containing infected attachments or links to malicious websites remain a common method used by attackers today.
Once they gain access through this door into your systems, sensitive data can be quickly encrypted before demanding payment for its release.
However, it's important to note that giving into their demands does not guarantee restoration of your data nor prevent future attacks since hackers often hold onto duplicates!
No one is safe from these threats - individuals, small businesses, large enterprises, government bodies, and hospitals are all potential targets.
By following these tips, you can significantly reduce the risk of falling victim to a ransomware attack.
Stay vigilant and stay safe!
By following these tips, you can significantly reduce the risk of falling victim to a ransomware attack.
Stay vigilant and stay safe!
Healthcare Sector Becomes A Prime Target
Healthcare Breaches: A Concerning Trend
As an industry veteran of 20 years, I've noticed a concerning trend: healthcare breaches are on the rise.
Healthcare providers have become prime targets for cybercriminals due to several reasons.
Why Healthcare Providers are Prime Targets
Data is incredibly valuable to hackers and medical records contain highly sensitive information such as social security numbers and medical histories that can be used for identity theft or sold on dark web marketplaces at high prices
Hospitals often lack strong digital defenses compared to other industries like finance or tech
Many institutions don't provide proper training in cybersecurity practices which leaves them vulnerable to attackers looking for weaknesses within their networks
Phishing attacks remain one of the most common methods employed by hackers where they send fraudulent emails disguised as legitimate ones with malicious links or attachments that infect systems once clicked upon.
"To combat this growing threat effectively requires a multi-pronged approach involving regular employee education programs about best practices when it comes to handling sensitive patient data along with implementing robust technical measures such as firewalls and intrusion detection systems (IDS) capable of detecting unusual network activity indicative of potential threats before they escalate into full-blown breaches."
Proactive Steps to Mitigate Risks
While there's no silver bullet solution against healthcare breaches given how sophisticated modern-day hacking techniques have become; taking proactive steps towards improving both staff awareness levels around cybersecurity risks coupled with investing in advanced technologies will go a long way towards mitigating these risks significantly over time - ultimately safeguarding patients' privacy rights from being violated unnecessarily!
My Experience: The Real Problems
1. The real root of data breaches is human error, not technology.
According to IBM, 95% of data breaches are caused by human error, such as misconfigured cloud servers or employees falling for phishing scams.
2. Companies prioritize profits over data security.
A study by Ponemon Institute found that 57% of companies prioritize profits over data security, leading to inadequate security measures and increased risk of data breaches.
3. Lack of accountability and consequences for data breaches perpetuates the problem.
Only 4% of data breaches result in any kind of legal action, according to a report by Verizon.
A study by the Government Accountability Office found that the government's ability to prevent data breaches is limited due to outdated laws and lack of resources.
5. Consumers prioritize convenience over data privacy.
A survey by RSA found that 78% of consumers prioritize convenience over data privacy, leading to a lack of demand for stronger data security measures from companies.
Rise Of AI Powered Cyber Attacks
The Rise of AI-Powered Cyber Attacks
As an industry expert, I've observed the rise of AI-powered attacks with increasing concern.
Cyberattacks using AI to breach systems and steal sensitive data have rapidly increased over the past few years.
One advantage these attacks have is their ability to learn from their environment and constantly evolve.
They can analyze massive amounts of data within seconds, identifying vulnerabilities in complex security systems more efficiently than traditional hacking methods.
The consequences are often catastrophic for businesses as they face an increased risk of financial losses due to fraud or theft of proprietary information such as customer details, intellectual property rights or trade secrets.
Reinforcement learning techniques: Hackers employ reinforcement learning techniques where malware adapts its behavior based on how it interacts with targeted devices' defenses until it finds a way through undetected.
Organizations must take proactive measures against these evolving threats by implementing advanced cybersecurity solutions capable enough not only detecting but preventing sophisticated cyber-attacks powered by artificial intelligence before any damage occurs.
Social Engineering Tactics Used By Attackers
Protecting Against Social Engineering Attacks
As an expert in social engineering tactics, I've noticed a concerning trend: attackers are increasingly relying on these methods to carry out data breaches.
Rather than solely exploiting technical vulnerabilities, hackers have shifted their focus towards targeting the human factor.
These types of attacks can be devastating for both individuals and businesses alike.
They often result in significant financial losses, reputational damage, and legal consequences if confidential data is compromised.
Attackers are increasingly relying on social engineering tactics to carry out data breaches.
Protecting Against Social Engineering Attacks
To protect against social engineering attacks, it's crucial for everyone (not just IT professionals) to:
Stay vigilant online by being cautious with suspicious messages/emails/websites/calls/texts/etc
Regularly update passwords/phrases/pins/security questions across all accounts/devices used frequently while avoiding reusing them between different services/platforms/apps/sites/systems/networks/cloud storages etc
To protect against social engineering attacks, it's crucial for everyone (not just IT professionals) to stay vigilant online.
My Personal Insights
As the founder of AtOnce, I have seen firsthand the devastating effects of data breaches on businesses.
One of our clients, a small e-commerce company, fell victim to a data breach that compromised the personal information of thousands of their customers.
Initially, the company was at a loss for how to handle the situation.
They didn't have the resources to hire a team of customer service representatives to handle the influx of inquiries and concerns from their customers.
That's where AtOnce came in.
Our AI-powered writing and customer service tool allowed the company to quickly and efficiently respond to their customers' concerns.
AtOnce was able to generate personalized responses to each customer inquiry, addressing their specific concerns and providing them with the information they needed to protect themselves from potential identity theft.
Thanks to AtOnce, the company was able to handle the data breach with minimal damage to their reputation and customer base.
They were able to quickly and effectively communicate with their customers, providing them with the support they needed during a difficult time.
This experience has taught me the importance of being prepared for a data breach.
With the rise of cyber attacks and data breaches, it's not a matter of if, but when, your business will be targeted.
By having a plan in place and utilizing tools like AtOnce, businesses can minimize the damage and protect their customers' sensitive information.
Insider Threats Become More Sophisticated
The Growing Sophistication of Insider Threats
Insider threats, referring to malicious activities carried out by individuals within an organization or with authorized access to sensitive information, are becoming more sophisticated.
These types of attacks can be harder to detect than external ones.
As an expert in cybersecurity, I've observed this concerning trend.
Why are Insider Threats Becoming More Complex?
One key reason for the increasing sophistication of insider threats is technology's widespread use.
As our workplaces become increasingly digitalized, employees have greater opportunities to misuse data and engage in fraudulent activities that could harm business operations
Additionally, cybercriminals may target insiders using carefully crafted social engineering tactics designed specifically for certain roles within organizations.
Additional Points About the Complexity of Insider Threats
Insiders can easily abuse their privileges without being detected
The rise of remote work has made it easier for trusted insiders with bad intentions to steal data from their employers' systems
It's also crucial that companies monitor network activity closely so any suspicious behavior is quickly identified and addressed before significant damage occurs.
In conclusion, while there will always be new challenges when it comes to protecting against cyberattacks like those posed by insiders who seek unauthorized access or cause intentional harm through fraud schemes - staying vigilant remains critical if we want our businesses safe from this ever-evolving threat landscape!
IoT Devices Create New Vulnerabilities
The Vulnerability of IoT Devices to Cyber Attacks
IoT devices are becoming increasingly popular worldwide, from smart speakers to home security systems.
However, as an expert in cybersecurity, I know that they pose a new and concerning vulnerability when it comes to data breaches.
Unfortunately, they all share one common weakness: their lack of built-in security measures.
Manufacturers often prioritize convenience over safety when designing IoT products, making them easy targets for even the most amateur hackers.
As a result, consumers must take proper precautions such as:
Keeping software updated
Using strong passwords
Otherwise, their device could be compromised at any moment.
"While there is no foolproof way to prevent every type of attack against connected devices, implementing best practices will go a long way towards protecting both personal information and sensitive business data alike from being stolen or misused by attackers looking for ways into vulnerable systems around us today!"
Protecting Yourself from Cyber Attacks on IoT Devices
By doing so, you can reduce the risk of unauthorized access by malicious actors who may try to exploit vulnerabilities in your system.
Regulatory Changes Impact Breach Response
Expert Insights: How Regulatory Changes Impact Data Breach Response
As an expert in data breaches, I know that regulatory changes can greatly impact how organizations respond.
With new regulations constantly being introduced, it's crucial for businesses to stay up-to-date if they want to effectively manage their breach response efforts.
The Impact of GDPR
One of the most impactful changes we've seen recently is Europe's General Data Protection Regulation (GDPR).
This regulation has forced companies worldwide to tighten security practices and be more transparent about handling user data.
Consequently, when a breach occurs, quick action and transparency with regulators and customers are necessary.
Failure could result not only in fines but also loss of reputation.
Key Takeaways
Stronger cyber-security protocols have become essential due to new regulations like GDPR.
Efficient response from organizations is critical for protecting against potential damage.
Quick action and transparency with regulators and customers are necessary.
Organizations must prioritize their response efforts to minimize the impact of a data breach.
By staying up-to-date with regulatory changes and implementing strong security protocols, businesses can protect themselves and their customers from potential damage.
Failure could result not only in fines but also loss of reputation.
It's important to remember that the consequences of a data breach go beyond financial penalties.
A company's reputation and customer trust are also at stake.
By taking proactive measures, businesses can mitigate the risks and protect their brand.
Emergence Of Deepfake Technology
The Threat of Deepfake Technology: What You Need to Know
As an expert in cybersecurity, I am deeply concerned about the evolving threat of deepfake technology.
Deepfakes are computer-generated forgeries that convincingly mimic human speech and actions using AI algorithms to create realistic-looking images and videos.
While deepfakes have been around for some time now, their latest iterations are incredibly sophisticated.
Cybercriminals can use them maliciously to impersonate someone else or deceive victims into divulging sensitive information like passwords and other confidential data.
It's essential always to stay vigilant against cyber threats like deepfakes because they pose significant risks not only in terms of security but also reputation damage if used maliciously against individuals or organizations alike.
Additionally, many companies use multiple different clouds which leads to confusion about where sensitive information resides; this adds complexity for IT teams without specific training in managing dispersed systems across numerous independent providers.
Cloud security is a shared responsibility between the cloud provider and the customer.
How to Secure Data on the Cloud
Here are some tips to help you secure your data on the cloud:
Choose a reputable cloud provider with a strong security track record
Implement multi-factor authentication to prevent unauthorized access
Encrypt your data both in transit and at rest
Regularly monitor your cloud environment for any suspicious activity
Train your employees on cloud security best practices
The key to securing data on the cloud is to be proactive and stay vigilant.
The Importance Of Proactive Cybersecurity Measures
The Importance of Proactive Cybersecurity Measures
As an experienced industry expert, I cannot stress enough the importance of proactive cybersecurity measures in today's digital era.
Reacting to a data breach can be incredibly costly both financially and from a reputation standpoint.
Therefore, businesses need to focus on preventing cyber threats before they happen.
What are Proactive Cybersecurity Measures?
Proactive cybersecurity measures involve:
Conducting regular vulnerability assessments
Implementing strong access controls and password policies
Hiring third-party security teams for additional support
These actions help secure networks, assets, and devices against potential attacks while mitigating risks that could leave systems wide open for intruders.
Investing in proactive cybersecurity should be at the top of every business owner's priority list.
It not only protects valuable assets but also builds customer trust while saving costs associated with reactive approaches post-breach incidents occur which may lead towards irreparable damages to one's organization as well as its stakeholders' interests too!
Final Takeaways
As a founder of AtOnce, an AI writing and AI customer service tool, I am always on the lookout for the latest trends in data breaches.
It's a topic that is always on my mind, and for good reason.
Data breaches can be devastating for businesses and individuals alike.
Over the years, I have seen many different types of data breaches, from simple phishing scams to sophisticated cyber attacks.
And while it's impossible to predict exactly what the future holds, there are some trends that I believe will continue to shape the world of data breaches in the coming years.
One trend that I believe will continue is the rise of ransomware attacks.
These attacks involve hackers encrypting a victim's data and demanding payment in exchange for the decryption key.
Ransomware attacks have become increasingly common in recent years, and I believe they will only become more prevalent as hackers become more sophisticated.
Another trend that I believe will continue is the targeting of small and medium-sized businesses.
While large corporations have traditionally been the primary targets of cyber attacks, smaller businesses are becoming more attractive targets as they often have weaker security measures in place.
So, how does AtOnce fit into all of this?
Well, our AI writing tool can help businesses create more secure and effective communication with their customers.
By using our tool, businesses can ensure that their emails and other communications are clear, concise, and free of any potentially harmful language that could be used in a phishing scam.
Additionally, our AI customer service tool can help businesses quickly and efficiently respond to customer inquiries and concerns.
This can be especially important in the event of a data breach, as customers will likely have many questions and concerns that need to be addressed in a timely manner.
Overall, while the world of data breaches can be scary and unpredictable, I believe that businesses can take steps to protect themselves and their customers.
By staying informed about the latest trends and using tools like AtOnce, businesses can stay one step ahead of the hackers and keep their data safe.
What are the latest trends in data breaches?
Some of the latest trends in data breaches include an increase in ransomware attacks, supply chain attacks, and attacks on cloud infrastructure. There is also a growing trend of attackers targeting Internet of Things (IoT) devices and using artificial intelligence (AI) to carry out attacks.
What are some predictions for future data breaches?
Some predictions for future data breaches include an increase in attacks on healthcare organizations, more sophisticated social engineering attacks, and an increase in attacks on small and medium-sized businesses. There is also a growing concern about the security of biometric data and the potential for large-scale breaches of this type of data.
What can individuals and organizations do to protect themselves from data breaches?
Individuals and organizations can take several steps to protect themselves from data breaches, including using strong passwords, enabling two-factor authentication, keeping software up to date, and being cautious when clicking on links or downloading attachments. Organizations should also implement security best practices, such as regular security audits, employee training, and data encryption. | eng | c03e7e2a-6804-449f-a5f9-7d2fceb977e8 | https://atonce.com/blog/latest-data-breach-trends-predictions |
summarize the specific role the baccalaureate nurse has in caring for the selected population
summarize the specific role the baccalaureate nurse has in caring for the selected population
Advancing Nursing Practice
Paper , Order, or Assignment Requirements
Purpose and Overview The purpose of this assignment is for the student to: discuss the roles of the baccalaureate nurse outside the acute care setting; identify a changing demographic population of interest; create a list of the special needs for the population; and discuss how to include evidence-based practice in caring for the population. Directions Please think about the role of the baccalaureate nurse who is caring for a changing demographic population of interest (Aging Population, Baby Boomer Generations, or Veterans). Interview a baccalaureate nurse working with the population selected. Based on your interview and discussion with the nurse: develop a list of the special needs of the population; search the literature and identify at least five evidence-based nursing interventions to address the special needs of the identified population; write a 3–4 page paper using the following guidelines: in 1-2 paragraphs, introduce the population and discuss the global healthcare needs of the population selected; in 1-2 paragraphs, discuss the special needs of the selected population; in 2-4 paragraphs, summarize evidence from the literature on the five nursing interventions used to address the special needs of the population; in two paragraphs write the conclusion for the paper in which you: discuss the value of evidence-based practice in addressing the population special needs: and summarize the specific role the baccalaureate nurse has in caring for the selected population | eng | 552fe5f0-b234-44c4-a9b7-3941e6f3fec1 | https://nursing-assignments.com/summarize-the-specific-role-the-baccalaureate-nurse-has-in-caring-for-the-selected-population-3/ |
On this year's International Women in Engineering Day (INWED), ABB CEO Björn Rosengren and Chief Human Resources Officer Carolina Granat discuss the importance of fostering an inclusive culture and encouraging diversity in the latest episode of the ABB Decoded podcast.
The INWED aims to encourage and support young women in building their careers in engineering. This ambition is strongly reflected in ABB's 2030 sustainability strategy, which has driving social progress as a key strategic pillar, with gender equality being an important element. As part of this strategy, ABB aims to double the number of women in senior management roles to 25 percent.
Being a global technology company, with engineering at its core, ABB has a long history of promoting STEM education and careers, especially for girls and women, in line with ABB's 2030 Global Diversity & Inclusion Strategy. ABB has partnered with more than a hundred universities across the world and offers numerous mentoring and scholarship programs.
In the new episode of the ABB Decoded podcast, Björn Rosengren shared his views on the way forward for empowering women and attracting the best talent in the market. "We talk about diversity, but to create that, it is actually the inclusivity, which is important – that people feel that they are part of the company and have really the same opportunities," Rosengren said.
ABB CEO Björn Rosengren.
ABB recently adopted the United Nations Women's Empowerment Principles (UN WEP's) in order to promote gender equality and women's empowerment in the workplace, marketplace and community. The UN WEP's are a primary vehicle for corporate delivery on gender equality dimensions of the 2030 agenda and the United Nations Sustainable Development Goals.
"From my perspective, I think it's important that ABB will always attract the best competence in the market. And when I'm saying that, it means that we need to have a broad recruitment base. That is important. So people working in the company should have the same opportunities, but also people who would like to join should feel that ABB is a company you can succeed in. Performance is what counts, and that gives you the opportunities," Rosengren added.
Diversity outperforms homogeneous teams
The latest episode of the ABB Decoded podcast also explores why gender diversity is crucial for the success of ABB. "I truly believe that diverse teams outperform homogeneous teams and I think that's extra-important when you are a company where innovation plays an important part, which is truly the case for ABB," Carolina Granat said. "International Women in Engineering Day gives us an opportunity to discuss what are the elements in our culture that might be obstacles to allowing everyone to have a career and for all of us to ask: 'what could I do differently to support this?' It's also an opportunity to feel supported as an employee."
Chief Human Resources Officer Carolina Granat.
In the context of this year's International Women in Engineering Day, ABB is re-emphasizing the need to further strengthen gender equality both within the workplace and in society, and to raise awareness among its employees against unconscious bias, stereotypes and discrimination. Already more than 7,500 senior managers at ABB have taken part in unconscious bias training | eng | 3a75c6db-553b-42ab-b29b-796bc50ff8fc | https://new.abb.com/news/detail/92526/everybody-should-feel-they-have-the-same-opportunities-abb-ceo-bjorn-rosengren-on-women-in-engineering |
The city of El Paso's Animal Services department offers people advice on how to keep their pets safe over the winter.
The city of El Paso's Animal Services department offers people advice on how to keep their pets safe over the winter.
Last Updated: 07 January 2022
Photo Credit:
Mark Lambie/ El Paso Times
The city of El Paso's Animal Services department is advising residents to keep their pets safe throughout the winter months.
Animal Services had received more than 200 reports in December, according to officials, for pets left outside without shelter and other winter-related events, as of Wednesday.
Officials advise pet owners to:
• Provide a warm location for pets to sleep and rest: If at all possible, bring them inside. Pets can be housed in a garage or a laundry room. If you must leave a pet outside, ensure that it has a decent shelter with four walls, a roof, and is located away from drafts. Provide dry blankets and rotate them on a regular basis to keep them dry.
• Recognize that some pets may require additional protection: Senior pets, pups, and canines with shorter coats may require additional protection from high temperatures. Take them for shorter outdoor walks to limit their time away from their shelter. Extra insulation, such as a sweater, pet socks, or shoes, can also be added.
• Clean up vehicle spills: Many drivers check and fill their cars with antifreeze, which can cause significant renal failure in dogs. Clean up any spills from your vehicle thoroughly to avoid pet deaths. Also, if you fear your pet has taken antifreeze, get immediate medical attention.
• Tap your car hood: Cats in the neighborhood seek warmth in engine compartments, with many sleeping under hoods at night. Before starting your vehicle, beat on the top of your hood or honk your horn to help prevent an accident.
• Keep wildlife at bay: Some animals, such as coyotes, are active year-round. Coyotes and other wildlife may explore neighborhoods in search of food during the winter months when food is limited. Pet bowls with food and water should be picked up because they can attract wildlife. | eng | da6a61a4-3608-430f-a961-3dd81bcc6e7a | https://www.petzooie.com/news-events/the-city-of-el-pasos-animal-services-department-offers-people-advice-on-how-to-keep-their-pets-safe-over-the-winter |
Wasn't his tweet in response to a tweet about an island ecosystem that had been isolated for 88million years? Obviously I am not defending Elon but this feels like a stretch. (Unless there was some other tweet of his that related to this dogwhistle as well? I don't have Twitter so idk 😅) I'm not denying he's done so many awful things and has shown far right dogwhistles, just that idk if this is one
edit: saw this tweet in another post on here and one of the commenters thought it was a weird coincidence that he'd respond to that specific tweet in that specific way shortly after trump met w a known white supremacist. So I get it now.
Lol idk I don't know how ppl are on this sub, bc I've seen ppl in others downvoted bc others think they like someone just bc they're not criticizing one specific thing they did. Good to know you just found it funny tho 😂 | eng | fe150dd0-8e7b-4226-b5ae-51f5bb10326d | https://rdt.trom.tf/r/WhitePeopleTwitter/comments/z5gkcx/88_is_a_white_supremacist_numerical_code_for_heil/ |
#first. Limit too large in size
The fatal weakness of the smartwatch is the size.
Yes, it must be compact, fashionable, not too heavy… so that the user can wear it to feel comfortable and true to its function, as a wristwatch. Therefore, smartwatches aim at a lot of things related to user experience:
Screen: The screen size is too small to experience the necessary content.
Currently, most smartwatches only display simple content such as heart rate, location, call notifications, answer calls, connections to devices in the same ecosystem, etc.
Reading newspapers, surfing the web or watching Youtube is possible, but of course it is only "for free", because you cannot watch with such a small screen.
The board is too small: The design of the motherboard must be small along with the limitation of internal components heat dissipation, so the performance of the system must also be reduced to ensure that it does not get hot or drain the battery during use.
#2. The price is too high
Currently, smart watches with full functions such as making calls, playing music, messaging and entertainment functions, or monitoring health are not cheap.
Like Samsung Galaxy Watch 3, the price is about 8-9 million VND. At this price, users can already buy themselves a mid-range phone, with full features without missing anything, even on par with flagships.
That price is still low, try touching your Apple Watch, it's hot
But as I said above, the experiences that smartphones bring are completely eaten away by smart watches, so it is clear that not many people accept to spend such a large amount of money to bring back a device. being fashionable is much.
Still know that comparing the watch with the phone it's a bit lame, but in terms of practical application and economy, it is clearly so!
#3. Damaged by external impact
Another obvious weakness of smart watches is that almost 80-90% of the time you use them during the day is worn on your hand.
No one buys a smart watch and puts it in a pocket or in a backpack, right? So the smartwatch is constantly exposed to the environment such as rain, sunshine, dust or even shocks.
Agree that there are water, dust or tempered glass features but they are only features, they are absolutely not something to ensure that the watch is not affected by external influences.
Compared to the phone, it is clear that the watch will have to be exposed to rain and sun and suffer a lot more physical impacts.
In short, not as expected, the smart watch that has developed so far has really not brought much change compared to the technology market in general.
They are like an addition, a little spice to the technology market, or from a business perspective to manufacturers as an extra revenue and do not affect production strategies. export or trade.
As for the user side, it is like a main technology fashion item and is it for fans of a certain brand, or simply love technology.
It is hoped that in the near future, when chip technology is becoming more and more powerful, developers will find a way to make smart watches do more, smarter, so that they can achieve more. meet the expectations that we expect.
Let's dream of a day like in science movies, tiny watches can take pictures, watch movies in a real way | eng | 3352ca1c-9337-43d5-8fc3-c9d4c8e37ab5 | https://natuts.com/after-years-of-development-what-does-the-current-smartwatch-have/ |
Alexandra Bachzetsis
The Stages of Staging
The Swiss choreographer Alexandra Bachzetsis incorporates performance, dance and visual arts in her work. Her main interest lies in the codes that govern gestures, both in everyday life and on stage.
In the monochrome interior of a gym strewn with blue mats and balls, ten performers rehearse the production of a video trailer. Slowly their 'real life' begins to blur with the performance, as surreal athletic training turns into frantic trance-like dancing, and personal confessions transform into pop songs.
How can one tell a story through moving images and the bodies that comprise them? Why stage privacy for an audience? Are we watching its construction, its failure or simply its trailer? Using film stills as research material, mats as projection surfaces for video close-ups and balls as props, the performance explores contemporary ideas of identity in terms of image-making, framing and athleticism. Video trailer: | eng | ca5d82da-9ad0-498f-8a02-0749d7dbe92a | https://www.hebbel-am-ufer.de/en/programme/pdetail/alexandra-bachzetsis-sos |
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How Your HVAC System Can Impact How You Cook Your Family Recipes – Mom Recipes
The AC you select impacts how you cook recipe for the family. Through conducting thorough research and gaining a thorough understanding of AC specifications, you'll be in a position to select the best AC suitable for the space you're cooking in. It is recommended to keep the temperature of your kitchen around 26-28 degrees Celsius by using a modest AC. This temperature optimizes the cooking process. Prior to installing AC in your kitchen, check the energy rating of the star. An AC equipped with an energy rating will be more effective in keeping power consumption in check and balancing energy consumption.
5. Gas Stoves Are Not Recommended
Even with a kitchen vent The greasy smoke from your cooking evaporates as it condenses on your cabinet, countertop, and the kitchen sink. The placement of your air conditioner near the stove isn't a good choice. It is a natural cooling procedure, an air conditioner absorbs or releases the air. Thus, placing an air conditioner close to an gas cooktop eventually leads it to absorb more of the steam generated while cooking. This may slow the process of cooling.
6. Don't install a central air conditioner in your kitchen.
Central air conditioning will likely have return and supply air in every room of your home. Return air is a great option, but despite its many benefits, a kitchen shouldn't utilize it because the scents emanating from cooking can be sent to the central air conditioner as well as distributed across the house. It can eventually lead to your house to become smokey and musty. The lack of return air could also trigger the air supply pressure to cause a negative force in the kitchen. The result is that the smell spreads across other rooms. Avoid using central air in the kitchen.
7. Change Your Cooking Methods
When you are considering installing an AC system to your kitchen area, there's a few extra things to think about. A majority of households use gas cook stoves for cooking. But just as times change, so do our kitchens. It is possible to transform your kitchen to a home theater. | eng | 8272df0f-5e91-4e0d-a1bf-1814cf819007 | https://websitereseller.co/how-your-hvac-system-can-impact-how-you-cook-your-family-recipes-mom-recipes/ |
PROTECTING THE HERD: WHY CHARLOTTE SHOULD CARE ABOUT MEASLES
News & Events
by: Julia Stullken, MPH student, and Dr. Jan Warren-Findlow, MPH Program Director and Associate Professor in the Department of Public Health Sciences
The recent measles outbreaks in Rockland County, New York (2019) and California (2015) are examples of how globalization and insufficient vaccination rates continue to affect the spread of infectious diseases. Measles was considered eliminated in the US in 2000, but due to reduced vaccination rates and increased international travel, the disease made a comeback in the latter years of the decade. This year, the US has seen the highest number of cases since measles re-emerged. The most recently reported outbreaks can be linked to individuals who were exposed to the disease outside of the US, whether due to travel abroad or emigration to the US. Many of the countries where measles was first contracted have lower vaccination rates due to poverty, poor health systems, vaccine shortages, or civil unrest. This makes vaccination prior to travel or upon arrival in the US of the utmost importance.
Measles is a highly contagious viral disease that can be spread through the air and can live outside the body for up to two hours. Infected persons can be contagious for up to four days prior and four days after the onset of the measles rash, which is the most common visual symptom. Other symptoms and complications of measles that make it dangerous include high fever and swelling of the brain. Because of its contagious nature, it is important for all levels of the population - from neighborhoods to states to regions - to maintain what public health officials call "herd immunity." Herd immunity is the idea that if enough people in a given area are vaccinated, it will protect those who are unable to get the vaccine for medical or religious reasons from acquiring a particular disease. Since measles is so contagious, at least 95% of a given population will need to be immune in order to prevent its spread to unvaccinated individuals and assume herd immunity.
What does Charlotte Have to Do with It?
Fortunately, Mecklenburg County hasn't reported any cases of measles since December 2014, when a single case was imported (meaning exposure occurred outside of the US). However, there are two characteristics about Mecklenburg County that make immunization compliance extremely important: the social and ethnic diversity of the county, and our position as a travel and business hub. Recent outbreaks in the US have been traced to international tourism, unvaccinated immigrant populations, and unvaccinated US citizens who travel abroad. In all of these instances, the virus was able to spread because of a lack of herd immunity. Having one of the largest airports in the Southeast means we are vulnerable to infection as travelers who have been exposed are passing through or are visiting Charlotte.
One of our strengths in Charlotte is our diverse and culturally rich population. However, our city and county also have neighborhoods with a wide range of socioeconomic statuses and ethnicities. Charlotte is, after all, an immigration hub. An article posted by the Pew Research Center found that Charlotte is one of the most densely populated metropolitan areas when it comes to undocumented immigrants. Approximately 100,000 people living in Charlotte in 2016 were undocumented immigrants. As practitioners and advocates for public health, our role is to ensure that everyone living in Charlotte is protected from infectious diseases and has access to vaccinations. Having accurate numbers on which communities are at risk is important, regardless of socioeconomic status, ethnicity, or documentation status. Vaccination rates are generally counted on a county-wide or state-wide scale, but not by neighborhood subgroups. Even county-wide vaccination rates are limited and not as comprehensive as is needed for proper disease surveillance.
It is difficult to measure the exact degree of vaccine coverage within an individual county due to a variety of factors (medical record keeping, migration, county funding/staffing, etc). In researching this article, we've realized how difficult it is to measure the overall immunization rate of a county at any given time. Many counties don't have a full-time Epidemiologist on staff; even counties who do often experience gaps in reporting from private healthcare organizations or pharmacies who offer vaccines. Since measles is a nationally reportable disease (meaning that confirmed cases must be reported to the state and ultimately the Centers for Disease Control and Prevention (CDC), wouldn't it make sense for vaccination against measles to be reportable as well? The North Carolina Immunization Registry (NCIR) requests immunizations be reported via an electronic record keeping system, but unfortunately not all providers participate in the registry. We require proof of vaccination for children who attend public schools, but as is the case in many counties, not all children are fully vaccinated within the first 30 days of the school year when data are collected. Not to mention, these measures don't account for children who aren't in public school or individuals who come to the US after school-age.
Of the three counties contacted for this article, Cabarrus County is the only one that was able to supply overall vaccination rates across the entire county. According to our source at Cabarrus County, only about 90% of five-year-olds in 2018 had received both recommended doses of the measles vaccine. Recall that to achieve herd immunity, 95% vaccination coverage is required. Gaston County was able to provide data on the number of reported Kindergarteners who had not met the required vaccination schedule in 2017 (approximately 8%); but they indicated that getting an accurate vaccination rate is difficult because of lack of communication between various providers and agencies. The NCIR does not supply county-specific data to the general public.
We were not able to obtain vaccination data from the Mecklenburg County Health Department (MCHD) prior to publishing this article. However, a source at MCHD indicated that the county does not internally measure overall vaccination rates across the county, and instead looks at the rates of vaccination provided in county health clinics. This is worrisome considering the extensive changes made to NCIR over the years to improve vaccination tracking, as well as our position as the largest metropolitan area in North Carolina.
Even though the CDC-reported vaccination rates for the entire state of North Carolina have remained close to herd immunity over the past few years (92% of children younger than three years old in 2017 received at least one dose of the MMR vaccine), an outbreak is not out of the realm of possibility. Not only will those children require a second dose at age five, but the data collected could be missing for the most vulnerable populations (for example, undocumented immigrants). To reach herd immunity we need 95% of the people in any given room, neighborhood, or city to be vaccinated in order to provide protection of those not vaccinated. Measles cases have already been reported in Tennessee this year, and the state has the same immunization rates as NC (92% of children under age three). Border states of South Carolina and Georgia have lower immunization rates (88% and 90%, respectively) which means they have a long way to go before they achieve herd immunity. Since measles has been reported nearby in Tennessee and Georgia, it is important that public health officials and medical providers are prepared for a potential outbreak in NC.
The Mecklenburg County Health Department (MCHD) has several ways of reducing risk and responding to outbreaks of vaccine-preventable diseases. The Communicable Diseases Program has ongoing contact and education efforts with local physicians to help them discuss vaccination with their patients. Alerts generated by the NC Department of Health and Human Services (NCDHHS) are forwarded to providers any time there is an important change in disease risk as defined by the North Carolina Immunization Branch and the CDC. These alerts include information about where outbreaks are occurring around the country and how many individuals have been affected as well as tips and resources for clinicians. For laboratory confirmed cases of measles, MCHD launches a complete investigation, including potential recent contacts with the patient, and measures to prevent further spread. MCHD follows the CDC's recommended course of action for preventing the spread of communicable diseases, including immunization, isolation, exclusion and quarantine of patients believed to have measles. Additionally, MCHD's strategic business plan includes programs and efforts to increase immunization rates, especially among school children.
What should you do about measles?
The best thing to do is educate yourself and your family about vaccination and make sure you are up-to-date with your vaccines. If you are skeptical about vaccination, talk to your primary care provider about the benefits and risks of immunization. Based on what we've learned from prior outbreaks, it is important to be vaccinated if you plan to spend time in schools, densely populated areas, or in areas frequented by travelers, such as amusement parks or airports. If you live with someone who cannot be vaccinated for medical reasons, you should be vaccinated to help prevent them from exposure. For more information about Mecklenburg county immunization clinics or where to find your immunization records, visit the Mecklenburg County Health Department website.
Public health officials and clinicians should ensure culturally competent information is available for diverse individuals within our community. This means providing information in different languages and working with community-based organizations to ensure that all areas of the county have adequate access to vaccination. Since measles vaccination requires two doses (the first by age two and the second at age five), strategic follow-up and education is necessary to keep parents and children from falling through the cracks. Preventing an outbreak like the one in New York will require efforts not only from health officials. Collaboration between travel agencies, large companies with many employees, schools, and community leaders is imperative to ensure the prevention and containment of measles.
Additionally, better data collection and stewardship is needed for us to understand the potential risk of an outbreak occurring, as well as helping health departments understand where to focus their resources. Clinicians and local agencies should take steps to participate in the NCIR and share data and resources with other agencies. The more complete our reporting, the better our predictions and recommendations will be.
Acknowledgements and Sources:
Dr. Shi Chen, Assistant Professor at UNC Charlotte
Susan Long-Marin of Mecklenburg County Health Department
Dana Rynk of Cabarrus Health Alliance
Leslie Sellers of Gaston County Department of Health and Human Services | eng | de646b55-427d-4868-840f-e80dc1f994d7 | https://publichealth.charlotte.edu/news/2019-06-13/protecting-herd-why-charlotte-should-care-about-measles |
CONTROLLED OBSERVATION
Controlled observation is a research method used to study the behavior of humans and animals under controlled conditions. It is a type of research in which the experimenter has control over the conditions and variables in the experiment, and is able to record and analyze the results. This article will discuss the advantages and limitations of controlled observation, and provide examples of how it has been used in research.
Controlled observation has many advantages. It allows researchers to control the environment and the variables in the experiment, and to record and analyze the behavior of participants in a more accurate and reliable way than other research methods. It also allows researchers to control for extraneous variables that may affect the results of the experiment. In addition, controlled observation allows researchers to study the behavior of participants in real-world settings, which can provide more accurate and reliable results than laboratory experiments.
Despite the advantages of controlled observation, it also has several limitations. First, it is costly and time-consuming to set up and conduct a controlled observation experiment. Second, it can be difficult to control for all variables in the experiment, which can lead to inaccurate results. Third, participants may not behave naturally in a controlled setting, which can lead to unreliable results. Finally, the results of a controlled observation experiment may not be generalizable to a larger population.
Controlled observation has been used in a variety of research studies, including studies of parenting, animal behavior, and cognitive development. For example, a study of parenting used controlled observation to investigate the effects of different parenting styles on children's behavior (Nelson et al., 2019). In the study, parents were observed in their homes for one hour, and their interactions with their children were monitored and recorded. The findings of the study showed that different parenting styles had different effects on children's behavior.
In conclusion, controlled observation is a valuable research method that allows researchers to study the behavior of humans and animals in real-world settings. It has many advantages, including the ability to control for extraneous variables, and to study the behavior of participants in real-world settings. However, it also has several limitations, including cost, difficulty controlling for all variables, and potential lack of generalizability. Despite these limitations, controlled observation has been used in a variety of research studies, and has been found to provide valuable insights into human and animal behavior. | eng | a18ab17e-f080-4883-96d3-4e3391f6dd47 | https://encyclopedia.arabpsychology.com/controlled-observation/ |
Why You Shouldn't Use ROI for Comparing Real Estate Deals
Small residential real estate investors, particularly beginners, often use ROI (Return on Investment) to compare investment deals and discuss their cash-on-cash returns with fellow investors. Undeniably, ROI, with its allure of 10%-20% returns, becomes the main deciding factor for many. However, relying solely on it to compare and make purchasing decisions can lead to dire consequences. This article will dissect this prevalent investment pitfall and introduce a more comprehensive approach to evaluating any potential real estate deal.
Why ROI isn't good for comparing the deals
vestment considering financial leverage. Utilizing a loan to acquire an investment property is a classic example of leveraging your investment. The degree of leverage is proportional to the loan-to-value (LTV) ratio – the higher the LTV, the greater the leverage. Hence, your ROI can vary significantly based on differing financing costs and leverage ratios, even for the same deal. To put it simply, you can potentially increase your ROI by opting for a higher leverage.
Consider this example: For an investment property valued at $200,000, with a financing interest rate of 4% and a 20% down payment, you can expect an ROI of approximately 15%. However, if you were to reduce your down payment to just 5%, your ROI could escalate to an impressive 24.8%. Remember, we're still discussing the same property here. Therefore, smart leveraging strategies can enhance your ROI significantly. However, investors should also be mindful of the increased risks associated with higher leverage.
Understanding the reasons why ROI (Return on Investment) may not be the ideal metric for comparing real estate deals requires a firm grasp of what leverage means and how to utilize it strategically. In the realm of real estate investment, leverage refers to the practice of borrowing capital at a lower interest rate to make a higher-return investment.
For instance, imagine an investment property projected to yield a 10% annual return. I could choose to invest my own funds, thereby securing a 10% profit on my initial capital, or I could opt for leverage, borrowing funds at a rate less than 10%. The advantage of leverage lies in its potential to offer theoretically unlimited returns, provided that the costs of financing remain lower than the expected rate of return. Consequently, the trick lies in ensuring a substantial spread between the financing interest rate and the anticipated return. Hence, leveraging in real estate investments, which implies borrowing money at favorable rates to invest in higher-return opportunities, can provide unlimited returns under the right conditions. This is why the simple ROI metric might not be the most accurate measure for comparing property deals. Understanding this concept is crucial to making savvy real estate investment decisions.
While we do not have much control over our financing costs, we can always try to pick the deal that has the best all-cash return (Cap Rate). Then, as a result, it would be the best deal no matter how much leverage we are taking or what's our financing interests rate.
Cap Rate, Then ROI and DSCR
New real estate investors often find themselves chasing Return on Investment (ROI) without fully grasping the underlying assumptions and potential risks. However, an effective strategy for property investment involves focusing on the Capitalization Rate (Cap Rate) initially. The Cap Rate is essentially the return one would reap if the property was purchased outright with cash, excluding any leverage. By adopting Cap Rate as a core purchase criterion, you're ensuring that your chosen property is a strong-performing asset.
Once you've successfully placed the property under contract and established a baseline for the Cap Rate, it's then appropriate to consider the level of leverage for that particular deal. Understanding leverage should always involve a thorough assessment of the associated risks. In the real estate sector, the Debt Service Coverage Ratio (DSCR) is a commonly used measure of these risks. Essentially, the DSCR provides a ratio of the expected monthly revenue to the anticipated debt service cost, which typically includes mortgage payments, property tax, and insurance premiums.
If the DSCR ratio barely exceeds 1, it's indicative of a potentially risky investment. Even a slight decrease in income could tip the balance and lead to negative cash flow. Consequently, a DSCR significantly greater than 1 is usually a safer bet. Given that you've already set a baseline for the Cap Rate, and have limited control over loan interest rates, the only element of the DSCR you can effectively manipulate is the leverage ratio, and this can be adjusted through varying the down payment amounts.
Therefore, successful real estate investing isn't solely about chasing high ROI; it's about striking a balance between ROI and DSCR to ensure you're considering both potential returns and the associated risks. Each investor's tolerance for risk varies, but understanding the trade-off between return and risk is crucial for anyone venturing into property investment.
Conclusion, also TLDR version
While scanning the market and trying to find a good deal to buy, investors should use the cap rate for comparing deals. After the property has become under contract, investors should understand the trade-off between return and risk and choose the strategy that's the best suited for them. For risk-seeking investors who are looking to expand their portfolio quickly, they can go with a lower down payment, which would result in a better ROI (better cash-on-cash return) but DSCR closer to 1(riskier). For risk-averse investors who are looking for good cash flow and less management overhead, a bigger down payment, results in a relatively lower, but still good ROI and higher DSCR. To calculate the Cap Rate, ROI, Cash Flow, and DSCR, investors can use PortfolioBay's free deal calculator to get a quick estimate and be confident in making sound investment decisions. | eng | 015980f8-ac15-4c6a-8b9f-2415e987c9a9 | https://portfoliobay.com/article/why-you-shouldnt-use-roi-for-comparing-real-estate-deals/ |