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1ab76019645a31da3b0448dcf00362c3 | Many ESBL-producing E. coli had significantly lower susceptibility to gentamicin ( p ＜ 0.0001 ) and the quinolones nalidixic acid ( p＝0.004 ) and ciprofloxacin ( p ＜ 0.0001 ) than non-producers . | [
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"start"... | [] | Antibiotic Susceptibilities and Genetic Characteristics of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Stools of Pediatric Diarrhea Patients in Surabaya, Indonesia. The purpose of this study was to investigate extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates from... | https://pubmed.ncbi.nlm.nih.gov/28003592/ | ### Instruction:
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6d1750301095d2936cc280ebf081c991 | The resistance of topotecan in MDR HL-60 cells was potently reversed by the addition of amlodipine . | [
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afc15f1af9a6d595687c65bfe26bec27 | In separate studies , the electrocardiogram ( ECG ) and cardiovascular effects of loratadine ( 30 and 100 mg/kg , i.v . ) , terfenadine ( 10 mg/kg , i.v . ) , promethazine ( 5 mg/kg , i.v . ) and diphenhydramine ( 20 mg/kg , i.v . ) were evaluated . | [
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"star... | [] | Antihistamine activity, central nervous system and cardiovascular profiles of histamine H1 antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea-pigs. Sedation limits the clinical utility of classical H1 antihistamines, while newer antihistamines such as loratadine and terf... | https://pubmed.ncbi.nlm.nih.gov/8556569/ | ### Instruction:
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2e896861e22edcf2d90edc62272567a9 | [ Clinical evaluation of effects from neoadjuvant chemotherapy with epirubicin plus paclitaxel in cases of locally advanced breast cancer -- comparative study of treatment with 2 and 4 cycles ] . | [
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[ Clinical evaluation of effects from neoadjuvant chemotherapy with epirubicin... |
5933f7af6df7dcb19a1acf8b3630c4dd | When systemically active chemotherapy doses were reached , further dose escalation was discontinued , and a phase II dose-range was established ( pemetrexed 500 mg/m(2 ) and carboplatin AUC = 5 - 6 ) . | [
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A phase I study of pemetrexed, carboplatin, and concurrent radiotherapy in pat... |
ae5a3d41fe6197db7a7fa13e47a8af4f | Increased dose density is feasible : a pilot study of adjuvant epirubicin and cyclophosphamide followed by paclitaxel , at 10- or 11-day intervals with filgrastim support in women with breast cancer . | [
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520dc3a18b14a57a368bcd964095071e | Those who test positive are treated with combinations of the following agents : omeprazole , clarithromycin , amoxicillin , tetracycline , and metronidazole . | [
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Pharmacist-managed Helicobacter pylori clinic. A pharmacist-managed Helicobact... |
2f4440a6312f23fd7a3100bd25f39c1e | Patients can be treatment-naïve for mCRPC or on first-line androgen receptor-targeted therapy for mCRPC ( ie , abiraterone or enzalutamide ) without evidence of progression at enrolment , and with no prior chemotherapy for mCRPC . | [
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] | [] | Intense Exercise for Survival among Men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL-GAP4): a multicentre, randomised, controlled phase III study protocol. Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT)... | https://pubmed.ncbi.nlm.nih.gov/29764892/ | ### Instruction:
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Intense Exercise for Survival among Men with Metastatic Castrate-Resistant Pro... |
f99dcdd01f6107affbfbbd94efa2f838 | CYP2D6 metabolizes other opioid analgesics , including tramadol , dihydrocodeine , oxycodone and hydrocodone , although they have been less systematically studied . | [
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Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer. c... |
84a375ec840963d68895d36ecd84f3c3 | Atracurium or vecuronium was given for intubation . | [
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] | [] | Prediction of oculocardiac reflex in strabismus surgery using neural networks. Successfully predicting an oculocardiac reflex (OCR) is difficult to achieve despite various proposed maneuvers. The aim of this study was to test the models built up by neural networks to predict the occurrence of OCR during strabismus surg... | https://pubmed.ncbi.nlm.nih.gov/10412336/ | ### Instruction:
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Prediction of oculocardiac reflex in strabismus surgery using neural networks.... |
76b596dbb2298d1ba4668068b940f4c9 | The data show that knockdown of Rad51 or BRCA2 greatly sensitizes cells to DSBs and the induction of cell death following temozolomide and nimustine ( ACNU ) . | [
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] | [] | Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy stil... | https://pubmed.ncbi.nlm.nih.gov/22073281/ | ### Instruction:
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Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylat... |
be817a111debcf11e63cf8c34861fed7 | The systemic treatment in both studies consisted of a four-drug-regimen ( VACA = vincristine , actinomycin D , cyclophosphamide , and adriamycin ; or VAIA = vincristine , actinomycin D , ifosfamide , and adriamycin ) and a total number of four courses , each lasting nine weeks , was recommended by the protocol . | [
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] | Second malignancies after treatment for Ewing's sarcoma: a report of the CESS-studies. During recent years, more intensified systemic and local treatment regimens have increased the 5-year survival figures in localized Ewing's sarcoma to more than 60%. There is, however, concern about the risk of second malignancies (S... | https://pubmed.ncbi.nlm.nih.gov/9788419/ | ### Instruction:
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a3e9deca9aeff608f039be706f6f2666 | Rationale , design , and baseline characteristics of a trial of prevention of cardiovascular and renal disease with fosinopril and pravastatin in nonhypertensive , nonhypercholesterolemic subjects with microalbuminuria ( the Prevention of REnal and Vascular ENdstage Disease Intervention Trial [ PREVEND IT ] ) . | [
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8aec468c4b89546f1205d002c2f46ab3 | In the present study , rabbits prepared with chronic vascular cannulae were used to study the effects of nicotine administration on plasma corticosterone , catecholamine ( epinephrine , norepinephrine and dopamine ) and glucose responses to physical restraint stress . | [
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Neuroendocrine responses to nicotine and stress: enhancement of peripheral str... |
2ff60aee3c52628cbf8ef1588d63a2cd | Phase III , randomized , double-blind , multicenter trial comparing orteronel ( TAK-700 ) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based therapy : ELM-PC 5 . | [
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Phase III , randomized , double-blind , multicenter trial comparing orteronel ... |
2696f2ed809244fe4362bf01ba2b9f1b | Five clinical trials with temozolomide or dacarbazine have been performed in metastatic colorectal cancer ( mCRC ) with selection based on methyl-specific PCR ( MSP ) testing with modest results . | [
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Digital PCR assessment of MGMT promoter methylation coupled with reduced prote... |
4d616b8b6d114e89d6958f931fe85aaa | Heparin infusion , followed by oral warfarin , is indicated for symptomatic thromboembolic disease as well as for asymptomatic patients with substantial proximal deep venous thrombosis or large pulmonary emboli . | [
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251f5f7c9560eb8b5c97eec74bfe8344 | Fluoxetine and paroxetine are potent inhibitors of CYP2D6 and administration of these SSRIs reduces the clinical benefit of an anticancer drug , such as tamoxifen , by decreasing the formation of active metabolites of this drug . | [
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Metabolic drug interactions between antidepressants and anticancer drugs: focu... |
81dbb19a67ef1985983527cb474e4352 | Epirubicin is an anthracyclin , analogous to doxorubicin , with a different toxicologic pattern . | [
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A phase II study evaluating the cisplatin and epirubicin combination in patien... |
6370dac70bb6f82f07d67292360f14ad | A total of 460 patients were randomized into four 10-day therapeutic schemes ( 115 patients per group ): ( i ) standard OCA , omeprazole , clarithromycin and amoxicillin ; ( ii ) triple OLA , omeprazole , levofloxacin and amoxicillin ; ( iii ) sequential OACM , omeprazole plus amoxicillin for 5 days , followed by omepr... | [
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"is_context_needed... | Clinical trial: clarithromycin vs. levofloxacin in first-line triple and sequential regimens for Helicobacter pylori eradication. Helicobacter pylori eradication rates with standard triple therapy have declined to unacceptable levels. ### aim To compare clarithromycin and levofloxacin in triple and sequential first-lin... | https://pubmed.ncbi.nlm.nih.gov/20180787/ | ### Instruction:
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Clinical trial: clarithromycin vs. levofloxacin in first-line triple and seque... |
1123d5ef9b6fdeb123b453991b3b6218 | Captopril in combination with HYZ significantly reduced BP compared with controls but T replacement increased BP and coronary collagen deposition in spite of HYZ and captopril treatment . | [
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2f5b79becc8a6e69aaa31e1c49f396d2 | Targeted therapy was administered to match the P1K3CA , c-MET , and SPARC and COX2 aberrations with sirolimus+ crizotinib and abraxane+ celecoxib . | [
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Personalized comprehensive molecular profiling of high risk osteosarcoma: Impl... |
6b6df6ff4095a8857ad554d4cf0c8f15 | EURAMOS-1 results do not support the addition of ifosfamide and etoposide to postoperative chemotherapy in patients with poorly responding osteosarcoma because its administration was associated with increased toxicity without improving event-free survival . | [
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10147e145cd0bdad159de619cec5c4f7 | The focus of this study is to investigate , whether altered expression levels of potentially relevant microRNAs ( miRs ) in serum are associated with response to trastuzumab or lapatinib . | [
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94f9dd27429e130f46f205da0891f4d4 | These results suggest that the addition of intravenous ceftriaxone during the first 3 days of hospitalization does not improve the cost-efficacy of oral norfloxacin in the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding and high risk of infection . | [
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056c7e350cc7a5271279359bfcf3bc9d | However , clindamycin possesses only one of the two mechanisms of lincomycin action , which is bacteriostatic , against Escherichia coli . | [
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64f929edb877af3cddf0c724ad66a1ba | This study evaluated the response rate of the combination therapy of aprinocarsen , gemcitabine , and carboplatin in previously untreated patients with advanced non-small cell lung cancer ( NSCLC ) . | [
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6d21b8fb44aec53cfdf566e8d7e95b68 | To evaluate the eradication of Helicobacter pylori by therapy with a combination of 60 mg lansoprazole and 800 mg clarithromycin . | [
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512ff22c22b6761f2530a2a9e49dbf3c | We identified 49 and 220 patients treated with sorafenib and sunitinib , respectively , as first-line therapy in the Asan Medical Centre from April 2005 to March 2011 . | [
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Comparative efficacy of sunitinib versus sorafenib as first-line treatment for... |
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e0cba36b58781c2288d8448732651b68 | Boosting darunavir with ritonavir instead of with cobicistat may be preferred if darunavir is to be combined with etravirine in clinical practice . | [
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6281f828d97fd01753786d649998ee0f | Single-agent paclitaxel and vinorelbine are recommended treatments for advanced breast cancer ( ABC ) non-responsive to hormone therapy and without visceral crisis . | [
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Randomized phase II study evaluating weekly oral vinorelbine versus weekly pac... |
f2c019857efd32ae3b64a68ef6a2ecd0 | Nal-IRI with 5-fluorouracil ( 5-FU ) and leucovorin or gemcitabine plus cisplatin in advanced biliary tract cancer - the NIFE trial ( AIO-YMO HEP-0315 ) | [
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3d1b9b7ba6eec890228902c4011a7d7f | Ten patients were withdrawn from the terbutaline group because treatment was insufficiently effective , whereas only one dropped out of the budesonide group . | [
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Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, b... |
d2ab326fb295d3755d481670624d8d1a | We conducted a double-blind cross-over study in ten volunteers aged from 19 to 30 years , to compare the pain control effects of a single oral dose of two analgesic compounds ( drug A : propyphenazone mg 250 , ethylmorphine mg 5 , caffeine mg 5 ; drug B : dipyrone mg 500 , diphenhydramine mg 12.5 , adiphenine mg 5 , et... | [
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[Electric stimulation of the dental pulp in the evaluation of the central effe... |
dbd8e4b1986c862f4f6959bc01ba9a08 | Forty-three mCRC patients who received cetuximab or panitumumab between April 2012 and December 2015 were the subjects of the present study . | [
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34d2058b1f46a61ed6efa1e0d2cc049f | Furthermore , 11 AML patients at primary diagnosis , including five AML patients with P-gp overexpression , who were treated with idarubicin , vepesid , and cytarabine V ( ara-C ) showed a complete remission . | [
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Clinical importance of P-glycoprotein-related resistance in leukemia and myelo... |
26b52a93d8e856f6c5071f06c51f1393 | Phase Ib Study of Bavituximab With Carboplatin and Pemetrexed in Chemotherapy-Naive Advanced Nonsquamous Non-Small-Cell Lung Cancer . | [
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Phase Ib Study of Bavituximab With Carboplatin and Pemetrexed in Chemotherapy-... |
d6601173b0972a426b9ca45a7a4f091c | In this multicenter study , the reliability of two nonradiometric , fully automated systems , the MB/BacT and BACTEC MGIT 960 systems , for testing the susceptibilities of 82 Mycobacterium tuberculosis strains to isoniazid , rifampin , ethambutol , and streptomycin was evaluated in comparison with the radiometric BACTE... | [
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Multicenter laboratory evaluation of the MB/BacT Mycobacterium detection syste... |
6201ec7c59b896456b430a50bd41c74f | Most frequent first line therapy was Sunitinib ( 66 % ) , followed by Sorafenib ( 20 % ) and Pazopanib ( 10 % ) . | [
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cac8b6d7e0e9cff86690aeac01a51b77 | Treatment of unresectable GISTs involves systemic chemotherapy with tyrosine kinase inhibitors , imatinib and sunitinib being first-line and second-line drugs . | [
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2bcb0a1c13e14733a47a2ce01f58095f | Such therapy has included weekly paclitaxel in combination with carboplatin/cisplatin plus topotecan , and carboplatin plus doxorubicin . | [
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5b73032843858b59999366946c1e2aeb | This phase II study was performed to assess the efficacy and safety of the combination regimen of temozolomide and docetaxel in patients with advanced metastatic melanoma . | [
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0cad00d5e84694cb17717fc3f749e2aa | Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer . | [
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86b8b2e11fa8569ee780430cc83fa446 | In a scenario analysis comparing pembrolizumab with ipilimumab , the estimated ICER was USD8,904 . | [
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Cost-effectiveness analysis of pembrolizumab compared to standard of care as f... |
0d17f81c5efb1b73b80eb287f32c69e0 | Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial . | [
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f2c24cda6984f8af1fd4c57784983b09 | To determine the current status of ivermectin , abamectin and praziquantel combined , and fenbendazole resistance to Parascaris spp . in horses in Saudi Arabia . | [
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fa9ec0fb6b4851232e80bbb0f13f1bab | The interaction of chloroquine and citalopram in vitro resulted in a synergistic response in the chloroquine-resistant strain but there was no interaction between the drugs in the chloroquine-sensitive strain -- a pattern found with other reversal agents . | [
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576c8ac8cc0fa93c995c35b5e17b8c95 | In a 27-day inpatient study , 10 methamphetamine-dependent individuals participated in a double-blind , placebo-controlled , cross-over design , with oral doses of topiramate ( 0 , 100 , and 200 mg ) administered as a pretreatment before intravenous doses of methamphetamine ( 0 , 15 , and 30 mg ) . | [
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6226da15ba7f4d73c2d17792fe9e79af | Synergism between penicillin , clindamycin , or metronidazole and gentamicin against species of the Bacteroides melaninogenicus and Bacteroides fragilis groups . | [
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363c8fe1e1792237985df9fbfb8e1a58 | Thirty-one animals were allocated randomly to three groups , all administered four boluses of 0.25 mg/kg rTPA every 10 min for 30 min , 17 mg/kg aspirin intravenously , and heparin ( as a 100 IU/kg bolus followed by infusion of 50 IU/kg heparin per h ) , hirudin ( as a 2 mg/kg bolus followed by infusion of 1 mg/kg hiru... | [
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bd1b614a9a5b0c1225075c98f84ca619 | In vivo evofosfamide was tumor suppressive as a single agent and cooperated with paclitaxel to reduce mammary tumor growth . | [
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Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in ... |
366808bdb989ebd4b56210b53fb3e265 | Paclitaxel and vinorelbine are among the most active new agents in metastatic breast cancer . | [
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5a93666939620e4a5416bd80da463252 | Treatments included recombinant human leptin ( 10 - 100nM ) , recombinant human IL-6 ( 0.3 - 3nM ) , or recombinant human erythropoietin ( Epo ) ( 10mU/ml ) . | [
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0cc39e9cd43eed735fbf93fa813da8a0 | Lenalidomide is currently being tested in combination with both standard and novel agents , including bortezomib , for patients with relapsed/refractory multiple myeloma . | [
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9b59233ac22acf3f6df19738ee0dccee | Analysis of HER Family ( HER1 - 4 ) Expression as a Biomarker in Combination Therapy with Pertuzumab , Trastuzumab and Docetaxel for Advanced HER2-positive Breast Cancer . | [
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5ed89d28b16c808ded0f444bde90dc63 | Hepatic arterial infusion of floxuridine and systemic administration of gemcitabine and oxaliplatin . | [
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3ed64085bfe928c461f9c17f9f8f5ac1 | Data from the New Zealand Intensive Medicines Monitoring Programme indicate that celecoxib 200 mg/day and rofecoxib 25 mg/day are/were the most commonly prescribed doses and that 6 % of patients had taken rofecoxib 50 mg/day for longer than recommended . | [
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22cc4576d56fdf21b9fcd4001d2e46f9 | Chemoimmunotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisolone combined with rituximab ( R-CHOP ) is currently the first-line therapy for diffuse large B-cell lymphoma ( DLBCL ) . | [
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f840117cf09b1a62ab954e23e6ccdf3a | The purpose of our study was to compare the survival of porcine lung allografts after induction with either cyclosporine A ( CsA ) or tacrolimus . | [
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Tacrolimus versus cyclosporine induction therapy in pulmonary transplantation ... |
69ce1c75c42d853e74eec788b249f146 | Cystoid Macular Edema during Treatment with Paclitaxel and Bevacizumab in a Patient with Metastatic Breast Cancer : A Case Report and Literature Review . | [
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Cystoid Macular Edema during Treatment with Paclitaxel and Bevacizumab in a Pa... |
fb1cdc336bfa44facd7d223ab0910933 | The results suggest that third-line chemotherapy with combined bevacizumab and S-1 is safe and may delay the progression of mCRC resistant to oxaliplatin and irinotecan with mutated KRAS . | [
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A Phase II Study of Third-Line Combination Chemotherapy with Bevacizumab Plus ... |
4aa4b4fdad3c2ed039c5ce33e2f3cef5 | In accordance with their different pharmacological profiles , the three NLs iloperidone , clozapine , and haloperidol have different effects in this preclinical cognitive task . | [
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Differential effects of iloperidone, clozapine, and haloperidol on working mem... |
38e0f18b20644a73a11a219785d8e7bf | In the comparison between rivaroxaban-based triple therapy and ticagrelor + aspirin , the RR was 1 and its 95 % CI remained within a post-hoc margin of ± 15 % . | [
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New oral anticoagulants in acute coronary syndrome: is there any advantage ove... |
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Analysis of HIV cross-resistance to protease inhibitors using a rapid single-c... |
bd9e3e4a321fffdb4c4e9ccdaf754cc3 | Maintenance Treatment With Low-Dose Mercaptopurine in Combination With Allopurinol in Children With Acute Lymphoblastic Leukemia and Mercaptopurine-Induced Pancreatitis . | [
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Maintenance Treatment With Low-Dose Mercaptopurine in Combination With Allopur... |
a43b30fbecc655bb6b300d1ce1cb8cf2 | The aim of this study was to assess the predictive and prognostic value of clinical response to second line treatment ( with capecitabine or with a two-drug regimen including irinotecan ) and to analyze its relation to selected clinical and pathological variables with respect to time to disease progression . | [
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Second-Line Chemotherapy of Advanced Colorectal Cancer: Predictive and Prognos... |
2e00802dc163aa6e6be87ebdb2ca208f | An 8-week , randomized , parallel-group , double-blind international trial comparing the once-daily single-pill combination of telmisartan 80 mg and amlodipine 10 mg ( T/A ; n = 352 ) with once-daily amlodipine 10 mg ( A ; n = 354 ) in patients with type 2 diabetes mellitus and stage 1 or 2 hypertension ( systolic BP [... | [
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63e916e263ec45ae78e3b37282fa746f | Pharmacokinetic studies evaluating the concurrent use of tenofovir and didanosine have been performed in healthy volunteers . | [
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14e658c0964fbb5b76fbaf6250621d8a | This comparative phase III trial of mitoxantrone+vinorelbine ( MV ) versus 5-fluorouracil+cyclophosphamide+either doxorubicin or epirubicin ( FAC/FEC ) in the treatment of metastatic breast cancer was conducted to determine whether MV would produce equivalent efficacy , while resulting in an improved tolerance in relat... | [
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] | [] | Results of a phase III prospective, randomised trial, comparing mitoxantrone and vinorelbine (MV) in combination with standard FAC/FEC in front-line therapy of metastatic breast cancer. This comparative phase III trial of mitoxantrone+vinorelbine ( MV ) versus 5-fluorouracil+cyclophosphamide+either doxorubicin or epir... | https://pubmed.ncbi.nlm.nih.gov/11378344/ | ### Instruction:
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Results of a phase III prospective, randomised trial, comparing mitoxantrone a... |
a4a0e2aa03eb1a3c7b02ab4d991eca20 | Overnight urinary oxytocin and vasopressin levels were obtained from 62 healthy males ( age range : 18 - 26 years ) to compare with trait measures of trust and aggressive behavior . | [
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Oxytocin, vasopressin and trust: Associations with aggressive behavior in heal... |
a852ffe5eeabb1b66257d24e56fa70bf | Additionally , the combined effect of Lapatinib together with Herceptin or Cetuximab on cell-mediated cytotoxicity was evaluated . | [
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aa87c9c97af30d5f0c6ba4db662cd97d | In a case-control study , we compared 52 consecutive patients undergoing isolated CABG on aspirin and clopidogrel 75mg/d versus 50 controls on aspirin monotherapy . | [
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Preoperative platelet aggregation predicts perioperative blood loss and rethor... |
53063ff66fc71e61d0f3a62bb493d9fe | The MBCs were 1 to 2 tubes higher than the broth dilution MICs for levofloxacin , 1 to 3 tubes higher than the broth dilution MICs for ofloxacin , 1 to 3 tubes higher than the broth dilution MICs for erythromycin , and the same as the broth dilution MICs for rifampin . | [
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Inhibitory and bactericidal activities of levofloxacin, ofloxacin, erythromyci... |
e7607395b589a9d6a885823a4bdd8d74 | Ketanserin ( a 5-HT2 antagonist , 10 mumol/L ) and tropisetron ( a 5-HT3 antagonist , 1 mumol/L ) had no effect . | [
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Ketotifen modulates noncholinergic contraction in guinea pig airways in vitro ... |
6f5e628682c1f970cc1c941f78c757f9 | This three-phase study was designed to determine if a pharmacokinetic drug-drug interaction exists between zidovudine and oxazepam . | [
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74c0e16ee5db2c1c5de0863213b10cdd | African American men were more likely to receive ketoconazole than abiraterone , enzalutamide , or docetaxel ( AME , 2.8 % ; 95 % CI , 0.7%-4.9 % ) . | [
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5fb2877fd458b4bee2e72b3106d5a0a8 | These observations are important in the development of vorinostat , and may have clinical implications on other cancer and noncancer drugs that are UGT2B17 substrates such as exemestane and ibuprofen . | [
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Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and... |
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Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-M... |
a07c1da8ac6e880d708e348dee854111 | The addition of dexmedetomidine to bupivacaine 0.5 % in EUS-CPN demonstrated beneficial effects as regards the degree and duration of pain relieve with negligible effect on the patient survival . | [
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] | Value of Adding Dexmedetomidine in Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis for Treatment of Pancreatic Cancer-Associated Pain. Abdominal and back pain is present in up to 80% of patients with pancreatic cancer and represents a significant cause of morbidity. Celiac plexus neurolysis (CPN) demonstrated goo... | https://pubmed.ncbi.nlm.nih.gov/32621112/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Value of Adding Dexmedetomidine in Endoscopic Ultrasound-Guided Celiac Plexus ... |
ee28ea04905713e9b380ad3cbd796d56 | The incidence of carcinoma , confirmed microscopically , was : control 14/20 ( 70 % ) ; high-dose gefitinib , 7/20 ( 35 % ) ; low-dose gefitinib , 7/20 ( 35 % ) ; high-dose meloxicam 7/21 ( 33 % ) ; and low-dose meloxicam , 12/20 ( 60 % ) . | [
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] | Chemopreventive effects of cyclooxygenase-2 inhibitor and epidermal growth factor-receptor kinase inhibitor on rat urinary bladder carcinogenesis. To examine the chemopreventive effects of a selective cyclooxygenase (COX)-2 inhibitor, meloxicam, and a selective epidermal growth factor (EGF)-receptor tyrosine kinase inh... | https://pubmed.ncbi.nlm.nih.gov/16469040/ | ### Instruction:
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### Input:
Chemopreventive effects of cyclooxygenase-2 inhibitor and epidermal growth fac... |
94de76aa894156859854546a83ca433f | Patients with incurable cancer causing chronic pain rated above 6/10 on a numerical scale while receiving high-dose opioid therapy ( more than 200 mg/d of oral morphine equivalent ) and/or exhibiting severe opioid-related adverse events received intrathecal infusions of ziconotide combined with morphine , ropivacaine ,... | [
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] | Ziconotide adverse events in patients with cancer pain: a multicenter observational study of a slow titration, multidrug protocol. Ziconotide is a new analgesic agent administered intrathecally. It is challenging to use and can induce several and sometimes serious adverse events. A low initial dosage followed by slow t... | https://pubmed.ncbi.nlm.nih.gov/22996851/ | ### Instruction:
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### Input:
Ziconotide adverse events in patients with cancer pain: a multicenter observat... |
68c9547776b2824a3e90e1f59b9b4366 | Both adalimumab and etanercept were more effective than methotrexate in slowing radiographic joint damage . | [
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... | [] | A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness. This report reviews the clinical effectiveness and cost-effectiveness of adalimumab, etanercept and infliximab, agents that inhibi... | https://pubmed.ncbi.nlm.nih.gov/17049139/ | ### Instruction:
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### Input:
A systematic review of the effectiveness of adalimumab, etanercept and inflixi... |
5386d10522b4ceab39a95e1adbc57b27 | Combination chemotherapy with gemcitabine ( Gem ) , doxorubicin ( Dox ) , and paclitaxel ( Pac ) ( GAT ) has been considered attractive as first-line treatment in metastatic breast cancer . | [
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] | Evaluation of a gemcitabine-doxorubicin-paclitaxel combination schedule through flow cytometry assessment of apoptosis extent induced in human breast cancer cell lines. Combination chemotherapy with gemcitabine ( Gem ) , doxorubicin ( Dox ) , and paclitaxel ( Pac ) ( GAT ) has been considered attractive as first-line ... | https://pubmed.ncbi.nlm.nih.gov/12036452/ | ### Instruction:
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### Input:
Evaluation of a gemcitabine-doxorubicin-paclitaxel combination schedule throug... |
e9da5f1b64d56f794f15c5887995e662 | Anti-cancer agents like adriamycin , mitomycin-C , bleomycin , and etoposide express their cell-killing activity partly through oxygen radicals . | [
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... | [] | Overcoming of cross-resistance to the cell-killing activity of oxygen radicals in VCR-resistant hematologic cell lines with cyclosporin-A. Anti-cancer agents like adriamycin , mitomycin-C , bleomycin , and etoposide express their cell-killing activity partly through oxygen radicals . Since vincristine (VCR)-resistant ... | https://pubmed.ncbi.nlm.nih.gov/9673368/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Overcoming of cross-resistance to the cell-killing activity of oxygen radicals... |
5f1a3d2c3e4b6683bc6cb633081ad7a6 | The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections . | [
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] | [] | The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections . This multicentre, randomised, open-label, parallel group study compared the efficacy and safety of isepamicin (15 mg/kg once daily) and amikacin (7.5 mg/kg twice daily) when given intravenously in combination w... | https://pubmed.ncbi.nlm.nih.gov/8622103/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
The efficacy and safety of isepamicin compared with amikacin in the treatment ... |
796ef671b82d8b62f17e74d857fe5411 | Imipenem was compared with nafcillin and with penicillin plus gentamicin in the therapy of experimental endocarditis induced in rabbits by Staph . aureus and Str . faecalis , respectively . | [
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] | Imipenem therapy of experimental Staphylococcus aureus and Streptococcus faecalis endocarditis. imipenem was very active in vitro against 36 Staphylococcus aureus isolates from cases of infective endocarditis; the MBC90 was 0.06 mg/l (four- to eight-fold more active than nafcillin). The in-vitro activity of imipenem ag... | https://pubmed.ncbi.nlm.nih.gov/6421794/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Imipenem therapy of experimental Staphylococcus aureus and Streptococcus faeca... |
2ffc3bc4a2d4cef091142559f41db561 | The total dose of paclitaxel ( 175 - 200 mg/m2 ) ; cisplatin ( 75 mg/m2 ) ; and etoposide ( 175 - 200 mg/m2 ) was divided into five daily doses administered over 3 h with cycles repeated at 21 - 28 days . | [
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] | Paclitaxel, cisplatin, etoposide combination chemotherapy: a multifractionated bolus dose schedule for non-small cell lung cancer. In this phase II study, paclitaxel was added to the combination of cisplatin and etoposide (TPE regimen), in 37 patients with advanced non-small cell lung cancer, using a multifractionated ... | https://pubmed.ncbi.nlm.nih.gov/9713270/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Paclitaxel, cisplatin, etoposide combination chemotherapy: a multifractionated... |
d3d3065094bd69c0fc64085832f1d55a | In this phase 3 trial , we randomly assigned ( in a 1:1:1 ratio ) patients with advanced renal cell carcinoma and no previous systemic therapy to receive lenvatinib ( 20 mg orally once daily ) plus pembrolizumab ( 200 mg intravenously once every 3 weeks ) , lenvatinib ( 18 mg orally once daily ) plus everolimus ( 5 mg ... | [
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] | Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma. lenvatinib in combination with pembrolizumab or everolimus has activity against advanced renal cell carcinoma. The efficacy of these regimens as compared with that of sunitinib is unclear. ### methods In this phase 3 trial , we randomly assi... | https://pubmed.ncbi.nlm.nih.gov/33616314/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma.... |
6f0476440606d257ae4a2266a30878d1 | Only chemotherapy by intravenous administration of 2 courses of 120 - 150 mg ACNU ( 1.7 - 2.2 mg/kg ) and 4 mg vincristine ( 0.06 mg/kg ) with intrathecal administration of methotrexate was given at this time . | [
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{
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] | A long surviving case of recurrent medulloblastoma displaying effectiveness of ACNU/vincristine chemotherapy. A favorable case of recurrent medulloblastoma, in which 19 years has elapsed with combination therapy due to surgery, radiation and chemotherapy since the initial operation, is reported. The case was a male of ... | https://pubmed.ncbi.nlm.nih.gov/8057133/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A long surviving case of recurrent medulloblastoma displaying effectiveness of... |
fac270cf9d9f839bc49728d2d4f38fc7 | In first-line treatment of intermediate- to poor-risk patients , the CheckMate 214 study demonstrated a significant survival advantage for nivolumab and ipilimumab versus sunitinib . | [
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{
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"text": "sunitinib",
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] | A Cost-Effectiveness Analysis of Nivolumab and Ipilimumab Versus Sunitinib in First-Line Intermediate- to Poor-Risk Advanced Renal Cell Carcinoma. The treatment paradigm of advanced renal cell carcinoma (RCC) has changed rapidly in recent years. In first-line treatment of intermediate- to poor-risk patients , the Check... | https://pubmed.ncbi.nlm.nih.gov/30710066/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A Cost-Effectiveness Analysis of Nivolumab and Ipilimumab Versus Sunitinib in ... |
b050c4f05066a38a88314ba7a6cf1d3a | In addition , docetaxel has a longer retention time in tumor cells than paclitaxel because of greater uptake and slower efflux . | [
{
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{
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] | [] | Preclinical pharmacology of the taxanes: implications of the differences. Taxanes are one of the most powerful classes of compounds among all chemotherapeutic drugs. Only 30 years separate the isolation of the first taxane from the results of direct clinical comparisons in metastatic breast, ovarian, and lung cancer be... | https://pubmed.ncbi.nlm.nih.gov/15161985/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Preclinical pharmacology of the taxanes: implications of the differences. Taxa... |
0cf78118eeb04f8f121db21b6dd8b17a | The total sample size was 103 , consisting of 31 , 23 , and 19 patients in olanzapine , risperidone , and clozapine groups , respectively and 30 controls . | [
{
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{
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"start": 1... | [] | Comparative study of sexual dysfunction and serum prolactin level associated with olanzapine, risperidone, and clozapine in patients with remitted schizophrenia. Sexual dysfunctions have been a major side effect of the second generation anti-psychotic drugs which often affects treatment compliance in patients with schi... | https://pubmed.ncbi.nlm.nih.gov/26816428/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Comparative study of sexual dysfunction and serum prolactin level associated w... |
3602ecfca299c3ee0a85bc8259f20cae | The relative analgesic potency ratios were 0.65 ( 0.56 - 0.76 ) for ropivacaine : bupivacaine , 0.80 ( 0.70 - 0.92 ) for ropivacaine : levobupivacaine , and 0.81 ( 0.69 - 0.94 ) for levobupivacaine : bupivacaine . | [
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{
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{
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"start"... | [] | Minimum local analgesic doses of ropivacaine, levobupivacaine, and bupivacaine for intrathecal labor analgesia. Doses for intrathecal opioid-local anesthetic mixtures have been arbitrarily chosen. The aim of this study was to compare the analgesic efficacies of intrathecal ropivacaine, levobupivacaine, and bupivacaine ... | https://pubmed.ncbi.nlm.nih.gov/15731605/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Minimum local analgesic doses of ropivacaine, levobupivacaine, and bupivacaine... |
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