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Several studies have implicated the role of oxidative stress in preterm birth [2, 3, 5, 8, 38–40]. A high level of systemic oxidative stress in the mother can cause placental dysfunctions or other damages leading to preterm labor [3, 8, 9, 37, 38, 41]. Most of pregnant women in our study (66%) had labored after 37 comp... |
Ważnym czynnikiem wpływającym na skład mikrobioty niemowlęcia jest antybiotykoterapia matki w czasie ciąży oraz w pierwszych tygodniach życia dziecka. Przyjmowanie antybiotyków w czasie 2 i 3 trymestru ciąży przez kobiety zwiększa ryzyko rozwoju otyłości o 84% u potomstwa w porównaniu z grupą dzieci, których matki nie ... |
Metaphase I cells were predominantly normal, but chromosomes (1 to 2) not lined up at the equatorial plate were observed in 21% (22/104) of the cells (Figure 3A). From anaphase I to telophase I, the percentage of cells with irregularities was notably high (∼87%, 123/141). Cells with infrequent chromosome bridges (∼18%,... |
Cette étude a montré pour la première fois que les milieux LJ supplémentés de VCNT à 10µg/ml de vancomycine pourraient être utilisés en complément des milieux LJ ordinaires pour la culture des mycobactéries, principalement dans les laboratoires qui sont confrontés à des taux élevés de contamination liés aux bactéries s... |
As pro- and anti-inflammatory cytokines such as IFN-γ, TNF-α, GM-CSF, RANTES, IL-17, IL-4, and IL-10 have an important impact on the antifungal host response, as well as cytokines such as IL-6 play a central role in the pathophysiology of GvHD, we assessed the gene expression and extracellular concentration of these mo... |
In the first trial (from 13 August to 7 September; cultivar Favori; production area 0.68 hectares), we compared 6 colored panels (size 25 × 40 cm): sticky traps (Trampas Cromotropicas of Interfase 3, Buenos Aires, Argentina)—blue, yellow; sticky cardboard panels (Impact Board traps of Russell IPM Ltd., Flintshire, UK)—... |
The relationship between inflammation and cancer has become an increasingly interesting but intricate area of research. Although inflammation has been identified as one of the hallmarks of cancer,18 the complex relationship between inflammation and the tumour microenvironment, promoting angiogenesis and malignant trans... |
We used a standardized questionnaire to explore the characteristics of the blood donors. Socio-demographic data including age, birth place, residence place, marital status, occupation, educational level, and housing conditions index were obtained from all participants. Housing conditions index was obtained by using the... |
Despite many years of study, fundamental questions remain regarding the codon usage of viruses. Does viral codon usage reflect primarily an adaptation of the virus to its cellular environment, or mutational processes directed by the host to fight the virus? How can viral genes be efficiently expressed, given the large ... |
The exclusion criteria included (1) a history of stroke; (2) major depression, with Hamilton Depression Rating Scale (HAMD) score > 24 points; (3) other central nervous system diseases that may cause cognitive impairment, such as Parkinson's disease, tumors, encephalitis and epilepsy; (4) traumatic brain injury; (5) sy... |
Prototype of the device presented in this study. Subfigure (A) shows the final CAD model of prototype, while (B) shows the device hardware components. Subfigure (C) report the “naked” device worn by a user. Subfigure (D) shows the final prototype worn by the user together with the different modules. |
Aufgrund dieser strukturellen Defizite bei T2DM ist die Knochenfestigkeit sowie die Steifigkeit und die Elastizität des Knochens in virtuellen FEA (finite element analysis) Untersuchungen vermindert. Microindentations-Untersuchungen zeigen zusätzlich strukturelle Einschränkungen als Ausdruck veränderter Kollagenverlink... |
δ‐Thalassemia is a form of thalassemia with no clinical consequences, and is caused by mutations in the δ‐globin gene that result in lower Hb A2 levels (Phylipsen, Gallivan, Arkesteijn, Harteveld, & Giordano, 2011). Although δ‐thalassemia has no clinical significance, the disrupted function of δ‐globin may lead to aber... |
Polineuropatia demielinizantă inflamatorie cronică (PDIC) este o patologie dobîndită, rară, de origine necunoscută, prezumtiv imunologică care afectează sistemul nervos periferic. Este cauzată de deteriorarea învelișului protector al nervilor (mielina). Boala afectează orice vârstă, ambele sexe; Incidența este de 0,8 l... |
Encouraged by the potent in vitro anti-inflammatory activity as well as the promising drug-like properties, the in vivo anti-ALI effect of 15a was further evaluated. As shown in Fig. 3A, the lung wet/dry weight ratio, an index of lung edema, was significantly increased after LPS-stimulation, compared with the control g... |
MAPSE measurements showed excellent inter- and intraobserver reliability in children without structural heart disease. Furthermore, echocardiographic image quality had only minor effects on MAPSE detection. However, M-mode derived MAPSE values were slightly but statistically significantly lower in limited image quality... |
In the present study, we performed a wide-ranging bioinformatics analysis of POD gene family and verified their role against various stress responses (i-e., NaCl, drought, and ABA) in grapevine. In total, 47 genes were identified for the first time in the grapevine genome and were systematically analyzed by genome-wide... |
Hierzu liegen eine Überblicksarbeit und eine Reihe einzelner Studien vor. Im Review von Khan und Ollenschläger finden sich Hinweise auf positive Effekte einzelner QS-Maßnahmen in Deutschland, jedoch nicht für die gesetzliche eQS, deren besonderes Kennzeichen darin besteht, dass sie jeweils ohne Vorstudien bundesweit e... |
Em 2019, o Conselho Federal de Medicina publicou um decreto que definiu a telemedicina como o exercício da medicina mediado por tecnologias para fins de assistência, educação, pesquisa, prevenção de doenças e lesões e promoção de saúde, regulamentando essa prática. A Sociedade Brasileira de Cardiologia publicou uma dir... |
JJL was involved in all processes related to study design, collecting samples and reviewing medical records, microbiological and molecular studies, analyses of data, and wrote this paper. ZKS and MD contributed to sample collection and microbiological and molecular studies. SB, FSH, HFM, and ZKJ contributed to this stu... |
IL17 induces a protective Th1 response against intracellular pathogens [16, 18, 22, 86]. Th1 cells are essential for the host to control mycobacterial replication by activating macrophage and CD8+ cytotoxic cells [119–121]. But how Th17 influences Th1 in Mtb infection is still an interesting question . The dynamics of ... |
Stability of SS-capped AgNPs synthesized at pH 11 when stored at different temperatures. (empty square) 5 mg/mL SS + 5 mM AgNO3, 37°C, (filled square) 10 mg/mL SS + 5 mM AgNO3, 37°C, (empty triangle) 5 mg/mL SS + 5 mM AgNO3, 25°C, (filled triangle) 10 mg/mL SS + 5 mM AgNO3, 25°C, (empty circle) 5 mg/mL SS + 5 mM AgNO3,... |
Systemic and vigorous RNAi response is pre-requisite for the RNAi based pest control using transgenic crops. Knowledge of siRNA machinery and their detail characterization not only explains the molecular mechanism of RNAi, but also indicates the probable response of target insects before developing the transgenic plant... |
The L2 cells were randomly divided into the following groups. 1) The control group (Control), in which cells were incubated with vehicle for 52 h 2) Anoxia/reoxygenation (A/R) group (A/R), in which the cells were incubated with vehicle for 24 h, and then exposed to 24 h of anoxia (1% O2-5% CO2-94% N2) followed by 4 h o... |
Given our interest in examining changes in movement planning in the untrained limb (i.e., errors at peak velocity), we chose to have participants initially train with their non-dominant (left) hand [2, 5, 6]. Participants completed a block of reach training trials with the left hand, after which intermanual transfer wa... |
For other extraction methods based on intensity images, which are generated from laser data, Husain et al. semi-autumnally extracted road boundary lines based on intensity images generated from laser points. Balado et al. used planar segmentation based on a split and merge operation method with geometric and topologi... |
We used the two word-sets employed by Souza and Oberauer (2018). One set consisted of words with high ratings of concreteness and imageability whereas the other set consisted of words with low ratings on both dimensions, which were selected from the “Semantischer Atlas” data base (Schwibbe, n.d.). Both sets were equate... |
The issue of how to compare the clinical performance of these predictors for hip fracture risk assessment is complex. There are two different questions that need to be answered:For a given predictor, given a group of patients, some who at the time of enrolment already had a hip fracture, and some who at the same time d... |
Przez dziesiątki lat określenie „emolient” dotyczyło wyłącznie substancji będącej składnikiem produktu kosmetycznego, której zadaniem było natłuszczenie, zmiękczenie, wygładzenie i pośrednie nawilżenie skóry, i takie nazewnictwo zastosowano w niniejszej pracy. Obecnie w terminologii kosmetologicznej i dermatologicznej ... |
Because PGA has potential for use as surface-contact adhesives , we were interested in discovering whether or not PGAIC retains the original function of PGA. Some material surfaces-coating tests were carried out using PGAICs dissolved in ethanol (0.1 wt % each), and the solvent that contains only 0.1 wt % partner surfa... |
In addition to providing catch and effort data, CODRS as a collaborative system could act as a precursor to co-management of a fishery . Collaborative approaches to fisheries management have gained traction in recent years as a potential solution to data-poor and open-access tropical fisheries such as those found acros... |
Analyse multi-variée: de l'analyse multivariée, il ressortait que toutes choses étant égales par ailleurs, les femmes qui n'étaient pas en couple, les femmes qui étaient à la recherche de partenaires et celles qui présentaient des tâches d'hyperpigmentation cutanée étaient plus susceptibles d'utiliser les PDV avec des ... |
Considering recombinant protein solubility as an indication of its correct folding and activity, our goal was to establish the conditions to obtain high production of soluble protein. Therefore, pET29-ArtinM was introduced in E. coli BL21-CodonPlus(DE3)-RP, a strain that contains the T7 expression system and extra copi... |
2. Non sono soggette all’autorizzazione dell’autore le attività indicate nell’articolo 64-quinquies poste in essere da parte dell’utente legittimo della banca di dati o di una sua copia, se tali attività sono necessarie per l’accesso al contenuto della stessa banca di dati e per il suo normale impiego; se l’utente legi... |
Aschenbach ist ein Bewohner des klimatischen Nordens, kontrolliert, sittsam, pflichtbewusst. Er sucht die Kühle und Kälte als klimatisches Pendant seines Wesens. Nicht zufällig sind die Protagonisten seines schriftstellerischen Werks, allen voran der Preußen-König Friedrich II., geprägt von einer Tapferkeit, die »in st... |
Anforderungen an den histologischen Befundbericht bei Lymphonodektomiepräparaten sind ([9, 12, 18, 26, 27], Abb. 1; Tab. 2):Angabe der Zahl der befallenen Lymphknoten im Verhältnis zur Zahl der entfernten/untersuchten Lymphknoten in Zuordnung zur Entnahmelokalisation (z. B. 4/13 inguinal links oder 0/15 inguinal links ... |
卡铂也是SCLC一线治疗的重要药物，特别是对老年患者耐受性明显好于顺铂。Fukuda等进行了氨柔比星联合卡铂一线治疗SCLC的Ⅰ期临床研究，16例患者入组，可评价病例为15例，分3个剂量水平，分别为氨柔比星40 mg/m2、35 mg/m2和30 mg/m2，均为第1、2、3天使用，卡铂均按AUC为5计算，第1天使用。其中2例CR，9例PR，3例稳定（stable disease, SD），1例进展（progressive disease, PD），中位生存期为13.6个月。最大的耐受剂量为氨柔比星40 mg/m2第1、2、3天，卡铂按AUC为5计算，第1天使用，推荐剂量为氨柔比星35 mg/m2第1、2、3天，卡铂按AUC为5计算... |
Excised tumors obtained from the experimental animals were paraffin-embedded. After obtaining adequate slides, the tissue samples were screened for Ki-67, PDGFA, VEGFA, VEGFR1, VEGFR2, PDFGRα, and PDGFRβ protein expression by immunohistochemistry. To that purpose, the tissues were deparaffinized, rehydrated, and subseq... |
Um dos primeiros ensaios clínicos apoiando o conceito de proteinúria como um fator de risco independente para a progressão da doença renal foi a Modification of Diet in Renal Disease (MDRD). Desde então, numerosas análises confirmaram essa observação. Assim, medicações hipotensoras para pacientes com doença renal basei... |
Im Ergebnis nicht unähnlich, aber mit einer anderen Akzentuierung der Beweggründe argumentiert der Ministerpräsident von Baden-Württemberg, Winfried Kretschmann. Er beruft sich darauf, dass es eine Wertehierarchie gäbe, in der Leben und Gesundheit an oberster Stelle stünden (SWR Aktuell 2020). Eine Abwägung muss also z... |
A taxa de sucesso clínico na remoção de eletrodos (91,8%) foi ligeiramente menor que nos centros de baixo volume do estudo ELECTRA (94,3%), o que também pode ter sido influenciado pelo tamanho amostral.25 Bongiorni et al., recentemente, relatam a sua experiência em um centro de alto volume europeu com uma taxa de suces... |
Major pathways of irinotecan metabolism and disposition. A reaction catalyzed by carboxylesterase-2 yields SN-38, the active metabolite. Glucuronidation of SN-38 to SN-38G is catalyzed by the enzyme UGT1A1. Several UGT1A1 polymorphisms exist, coding for a spectrum of enzyme expression and varying ability to metabolize ... |
The findings of this review demonstrate that dietary nitrate (NO3 −) supplementation may reduce the oxygen cost of exercise, elevate arterial and tissue oxygenation, improve muscle metabolic function, and enhance exercise capacity/performance at simulated altitude.Current preliminary evidence from training studies cond... |
(A) Phase contrast imaging of the cells shows no apparent adverse effects on morphology of cells exposed to GA-1 or GA-2 or CP-1 or CP-2 at either concentration. Exposure to CP-3 at both concentrations showed morphological changes consistent with cell death. (B) Cell lysates were assessed by CTG assay to determine rela... |
Whey protein (WP) has been shown to be able to regulate impaired wound healing normally . Here we aimed to find a correlation between the achievement of normal healing in diabetic wounds by WP and the regulation of two important markers, Hsp72 and Krt16. |
The models for the STAT3-Tip complexes were based on the crystal structure of STAT3 [PDB entry 1BG1 ]. This structure represents an activated STAT3 homodimer, in which the Y705-phosphorylated C-terminus is bound to the SH2 domain. For modeling, one SH2 domain (residues 584–688) with its interacting C-terminus (residues... |
All methods for studying bats have potential advantages and disadvantages. Catching bats often allows better species‐level identification than acoustic methods and allows the collection of data on biometrics, sex and reproductive status, and genetic material. However, it is time‐consuming, invasive, and can lead to bia... |
Additional file 1: Table S1. Summary of quinine pharmacokinetic studies in children with malaria (uncomplicated malaria and complicated malaria). Pharmacokinetic parameters (Cmax and systemic exposure) are presented as mean + SD or mean or median (range) or median values. Table S2. Summary of quinine pharmacokinetic st... |
NK cells harvested from 12-week old C57/BL6 mice spleens with a MagCellect Mouse NK Cell Isolation Kit (R&D, Minneapolis, USA) were treated with murine IP-10 (10 ng/ml, 50 ng/ml, 100 ng/ml) accompanied by 6 hour oxygen glucose deprivation (OGD) in Hank’s Balanced Salt Solution (HBSS) (Ca-Mg-free, glucose 1 g/L). Mean f... |
Many environmental factors such as allergens, air pollutants, especially cigarette exposure, damage the intercellular junction complexes and disrupt the airway epithelial and endothelial barrier function. Thus, bronchial and lung epithelial permeability increases. Increased epithelial permeability causes exposure to mo... |
Here, we first create a copy of l. After performing the filtering on copy, we use forEachOrdered, provided by the Stream API, to add each element of the temporary stream back to the list pointed to by l (in the order encountered in the stream). Thus, we are not creating a new list with a new reference, but using the or... |
Vâscosuplimentarea este un tratament sigur, eficient și bine stabilit al osteoartritei și constă în injectarea unei soluţii pe bază de acid hialuronic (HA) în articulațiile afectate. Terapia comună de vâscosuplimentare este concentrată în principal pe tratarea simptomelor, cum ar fi reducerea durerii, dar nu tratează c... |
Our finding that dysfunctional telomeres are produced only in cells depleted of both hnRNP A1 and A2 is consistent with the hypothesis that these 2 proteins perform complementary functions in telomere maintenance. However, the depletion of hnRNP A1/A2 did not inhibit cell proliferation in normal mortal human cells . On... |
The analyses of numerical intensities under the different polarization directions that are shown in Fig. 5a’–d’ help to explain the experimental polarization-resolved patterns shown in Fig. 5a–d. Figure 6a–d illustrate the experimental polarization-resolved patterns corresponding to the flower mode shown in Fig. 3e. Th... |
LR73 cells stably expressing HA-Tim-4 or LR73 cells transiently transfected with the indicated plasmids were incubated with TAMRA-labeled apoptotic thymocytes. Two hours after incubation, the phagocytes were extensively washed with ice-cold PBS. Then, the cells were trypsinized, stained with anti-HA antibody and Alexa ... |
To test this possibility, aggregates of Sema3C-expressing HEK293T cells were placed in the repulsive septal region of E16.5 WT slices (Figure 7Bi ). Callosal axons were misrouted from their normal path and invaded cell aggregates expressing Sema3C (Figure 7Biii–7Biv ; arrowheads; n = 13 out of 16), whereas control cell... |
All the subsidiaries had an overall positive opinion about the WEEE directive. However, in several of the countries, there was a fear of making mistakes. To be labeled as a “free-rider” or a company that did not have control of its environmental obligations was seen as devastating. As two of the PROs stated, because me... |
Techniques of bone lengthening vary, and the hardware used for bone lengthening has advanced over time. The circular external fixator, unilateral external fixator, and axial internal fixator are the most frequently used for the treatment of LLD . The basic principle behind these techniques is the same. They take advant... |
In this study, in order to investigate the neuronal mechanisms associated with smoking, we conducted a resting-state fMRI experiment in which twenty-one heavy smokers were scanned in two sessions: smoking abstinence followed by smoking satiety. We proposed a novel analysis framework combining ICA and GCA to inspect bot... |
Initial bioprocess development involves a comprehensive screening program to identify the best suitable biological system in combination with feasible process parameters. Shaken bioreactors, in specific shake flasks, have become established screening tools to obtain process-relevant information [1, 2]. Since convention... |
Among the four treatments, the patients of high dose rate brachytherapy demonstrated the worst oncological outcomes, especially in D’Amico intermediate- and high-risk groups. Besides, the patients of radical retropubic prostatectomy had more complications rate in urethral stricture and urinary incontinence. Moreover, t... |
An alternate analysis was run using only the main effect regressor. Separating the participants into “high eye contact dyads” and “low eye contact dyads,” the contrast of High eye contact (Social > Non-social) > Low eye contact (Social > Non-social) was computed to further illustrate the effect of the high eye contact ... |
South Africa is a patriarchal country in which the role of the father as the primary authority figure in the household has a powerful impact on family life (11). Patriarchy in South Africa today is considered by many to be a “serious societal illness, and often the root contributor of violence against women and childre... |
The evaluation of parameters related to chlorophyll fluorescence provides a diagnosis of the effects of plant-environment interactions on the performance of PS2 and, if these effects are harmful, they can reduce the functioning efficiency of this machinery . The correlation between Fv/Fo and Fv/Fm, was positive and mod... |
Figure 6 shows the actual class rank after year 1 (CREY1) vs. the predicted class rank (PredCR) based on the GRE-QV and GPALast45hrs predictors only. This figure also shows the 25th and 75th percentiles of CREY1 as well as the upper and lower 95% prediction limits for PredCR. The utility of this figure is that the 75th... |
Odds ratio for ED was higher in female smokers than in male smokers (1.44, 95% CI: 1.40–1.49 vs. 1.13, 95% CI: 1.09–1.17). When adjusting regression models for systolic blood pressure and VO2 peak, smoking was no longer associated with low FMD in men, but persisted in women. More detailed analyses of the effect on endo... |
Ningún país incluye todas las medidas de verdadera equidad en los sistemas de salud, pero algunos incluyen varias de estas medidas, como mejorar la accesibilidad física y financiera, y ampliar el acceso a los medicamentos para los grupos poblacionales socialmente excluidos. Fueron menos los países que abordaron otros a... |
As soon as a live shark was landed, a core temperature was immediately assessed by inserting a 20 cm piercing thermometer (VWR, Radnor, PA) into the thickest portion of the dorsal musculature, which was typically 1 cm to either side of the first dorsal fin. The piercing thermometer was inserted 1.5 to 7 cm into the mus... |
A identificação das alterações morfológicas ou de propriedades elásticas dos tecidos moles com o uso dos métodos de imagem tem se tornado um importante e crescente foco de pesquisa, visando obter uma avaliação mais precisa do grau de dano e do enrijecimento dos tecidos. Entre esses métodos, destaca-se a avaliação por e... |
Entsprechend der Bewertung der erkannten Risiken ist insbesondere denjenigen in der rechten oberen Ecke von Abb. 4 (rot) entgegenzuwirken. Hier mussten zuvorderst die fehlerhafte Gasmengenplanung (O1), fehlende Gasvorhaltung (O3) und eine unzureichende Führung (T6) bei der Bewältigungsplanung in den Fokus genommen werd... |
L'imagerie par résonance magnétique (IRM) est jugée supérieure à toutes les autres techniques d'imagerie médicale: échographie, TDM et tomographie par émission de positons (PET-scan) pour le diagnostic des lésions hépatiques focales . L'aspect IRM, en particulier sur les séquences T1, T2, de diffusion et gadolinées ave... |
Ecological impact: beavers, tree leaves and earthworms were chosen. Beavers were chosen for being ecosystem engineers, managing to model entire landscapes including habitats and damaged streams by constructing their dams. Tree leaves can absorb organic compounds from the atmosphere and break them down to be less harmfu... |
Field case of a steer with hemorrhagic diathesis presenting epistaxis and profuse salivation (A), abomasum with multifocal to coalescent ulcers with a large blood clot attached in a spontaneous case (B). Bovine with diffuse severe trilineage hypoplasia of the bone marrow (C). Bone marrow of a control steer (D). |
Another important question is whether there is a distinct regulation of the repertoire selection, differentiation and persistence of high- versus low-TCR–pMHC affinity/avidity antitumor CD8 T cells in vivo. For instance, numerous studies conducted in mouse models (70, 161–165) or ex vivo analysis of human T cell respon... |
The primary outcome of the study is the rate of BMI growth. We hypothesize that in the intervention arm, the rate of BMI growth will be less than the comparison community after three years of the intervention. We assess BMI, abdominal circumference and skinfold thickness in eligible children in both communities every s... |
In summary, we believe that T cells pave the road that unravels the partnership of the three systems (i.e., immunity, hematopoiesis, bone homeostasis) by acting as messengers from the periphery to the bone cavity. It is clear that inside the BM, T cells bring information from the periphery. They produce cytokines and e... |
To further support this conclusion, two control experiments were performed. First, we investigated whether growth of the producer strain was indeed caused by the extracellular production of GlcN due to secretion of active TkCDA into the medium by the substrate converter strain. To this end, the producer strain CgLYS4 w... |
(A) – Samples from PC3 and LNCaP cells treated without/with (S)-2 (2.5 and 5 µM) for 24 h were analysed by Western blot and immunodetected for: PARP and its cleaved fragment, γ-H2AX and acetyl-α-tubulin, while α-tubulin was used as loading control. (B) – Cells either untreated or treated with 2.5 µM (S)-2 for 48 h were... |
The efficiency of the three monocyte sub-sets to bind zymosan does not differ according to infection status. A). The proportions of each monocyte sub-set that bound Alexafluor488-conjugated zymosan bio-particles compared between participants grouped according to schistosome infection status (un-infected, infected and c... |
Bacteria engage in the cell-cell communication process called quorum sensing (QS) to coordinate group behaviors. QS relies on production, release, and group-wide detection of extracellular signal molecules called autoinducers (AIs). QS-mediated communication systems are now known to be common in the bacterial domain (1... |
La fibrillation atriale (FA) et l’insuffisance cardiaque (IC) sont des maladies cardiovasculaires souvent associées, leur coexistence aggrave le pronostic et constitue un problème de santé public majeur . La prévalence de la FA dans la population générale est estimée à un 1%, elle augmente significativement chez les su... |
Najnowsze rekomendacje dotyczące diagnostyki i leczenia EoE u dzieci i dorosłych zostały opublikowane w 2017 roku . Wymienione zalecenia zostały opracowane przez międzynarodową grupę roboczą złożoną z ekspertów pod kierunkiem Lucendo i pod auspicjami towarzystw naukowych. W skład tej grupy weszli specjaliści z dziedzin... |
Existen problemas importantes en la transmisión de los datos científicos sobre la exactitud de los dispositivos de presión arterial a los usuarios concretos (15, 16, 41, 43-45). Durante varios decenios se han publicado muchos artículos importantes sobre las deficiencias de la medición de la presión arterial (10, 46), p... |
Pour ce qui est des germes isolés, les bacilles Gram négatifs sont les plus fréquemment identifiés dans les milieux de culture au cours de notre étude, et en chef de fil l'E. Coli, la Klebsiella Pneumoniae et le Pseudomonas Aeroginosa. Ceci a également été retrouvé dans plusieurs séries internationales [7–9]. De récent... |
To identify recurrent APL-associated mutations, we combined this data set with three other whole-exome sequencing studies of APL [12–14] for a total of 164 sequenced cases, and identified 70 recurrently mutated genes (i.e. mutated in two or more cases of APL). We identified a mean of 2.0 and 2.2 recurrent mutations per... |
Trotz dieser vielversprechenden Ergebnisse sind viele Anwendungsfragen (effektiv erreichtes Verteilungsvolumen im Gehirn nach Gentherapie?) sowie wichtige Sicherheitsfragen (DNA-Schädigungen durch CRISPR/Cas9? Immunvermittelte Reaktionen auf die Präsenz eines bakteriellen Proteins?) noch ungeklärt. |
Der Berufsstatus als wichtiger sozioökonomischer Indikator der beruflichen Lage steht in engem Zusammenhang mit Gesundheit [19, 20]. Zur Bestimmung des individuellen Berufsstatus werden das Einkommen und die Qualifikation der Beschäftigten in den nach der „Klassifikation der Berufe 2010“ codierten beruflichen Tätigkeit... |
It is vital for health education interventions to aim at long-term changes to the health behaviour and the norms that are attributed to a health problem. However, evaluation of the effectiveness of interventions depend on documenting the outcomes, effects, formation, process, cost-effectiveness and benefits of the inte... |
La NAFLD si associa a una maggiore incidenza di patologie cardiovascolari, con cui condivide molti fattori di rischio metabolici. È stato infatti osservato che i pazienti con NAFLD presentano disfunzione endoteliale, aumento della rigidità delle pareti delle arterie e aumento dello spessore dell’intima-media carotidea,... |
An 8-year-and-1-month old Caucasian female presented to her pediatrician with complaints of nocturnal enuresis and hyperactivity. Child was adopted at 2 years of age along with her younger sibling due to history of parental neglect by biological parents. Adoptive parents reported hyperactivity as a major concern. Physi... |
Ab-initio calculations were performed based on the density functional theory (DFT) within the generalized gradient approximation (GGA) as implemented in the SIESTA computational code within the Perdew-Burke-Ernzerhof (PBE) form . The core electrons were replaced by Troulier-Martins pseudopotentials . A double-ζ basis ... |
In addition to assessment of bone formation, we also examined if the transplanted BMP-hBMSCs could directly contribute to the formation of bone tissues. Since only samples in Gene group could form bone, four constructs from this group were implanted intramuscularly. After 14 or 28 days, samples were collected for histo... |
Se le hicieron sesiones de fonoaudiología desde el nacimiento por ausencia del reflejo de succión, disfagia preoral y oral, y riesgo de broncoaspiración. Se realizaron 25 sesiones centradas en la estimulación de los músculos implicados en la succión y la deglución con lo que, finalmente, logró una succión efectiva con ... |
Zowel dubbel-J-stents op zichzelf, als een langere verblijfsduur van dubbel-J-stents bleken beide geen significante risicofactoren te zijn voor postoperatieve gecompliceerde urineweginfecties. Vrouwelijk geslacht, preoperatieve positieve urinekweken en recidief van urolithiasis bleken wel significante risicofactoren. |
This paper is inspired by the work of Li et al. that presented the simulation of some trajectories performed by a three-wheeled omnidirectional mobile robot and also analyzed the limitations found in a real implementation of these trajectories. In this direction, the new contribution of this paper is the experimental ... |
Zur Gewährleistung der Versorgung von Patienten mit chronischen respiratorischen Erkrankungen während der SARS-CoV-2-Pandemie wurde im März 2020 ein bundesweites Projekt zwischen Leistungserbringern aus der Pneumologie und Industriepartnern initiiert. Dieses basiert auf einem App-gestützten digitalen Versorgungskonzept... |
MTase activation through dimerisation of two viral protein partners has already been reported in the case of the vaccinia virus D1/D12 N7-guanine MTase. However, the activating D12 subunit does not contact the D1 subunit through a homologous surface mainly defined by canonical αA and αZ helices. Rather, the D1/D12 acti... |
Diagnostic accuracy of optical coherence tomography angiography parameters in discriminating patients with cerebrovascular disease. AUC for average pRNFL + average GC-IPL = 0.590; AUC for average pRNFL + average GC-IPL + central VD + whole VD = 0.913; and AUC for average pRNFL + TS GC-IPL + central VD + whole VD = 0.91... |
In Figure 5, it can be observed that the maximum value of oxidation heat is of the order of 103Wm2, which is much lower with respect to the aerothermal heat flux order (106Wm2). In this condition, the emissivity observed on the sample’s front surface was assumed to be function of the temperature in accordance with expe... |
The electron microscopy showed that EE improved the number of ipsilateral synapses after pMCAO compared with the SH group. The number of ipsilateral synapses was significantly higher in the SH group than in the sham group. Interestingly, a significant difference in the number of contralateral synapses was found between... |