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203,003 | Autophagy plays a critical role in cellular homeostasis by clearing damaged or unnecessary organelles or macronutrients dependent on the lysosomal degradation pathway (Xie et al., 2011). Dysfunction of autophagy is shown to be involved in diabetic cardiomyopathy (Lavandero et al., 2015). It has been revealed that H2S i... | 4 | 0biomedical | 0Study |
244,692 | The study has several limitations. The cross-sectional study design is a major limitation of this study. Furthermore, to participate in the survey, the respondent must be 18 years old and literate. The convenience sampling technique was used under the non-probability sampling method according to the objective and natur... | 2 | 0biomedical | 0Study |
370,929 | Given the high metastasis relapse rate of breast cancer patients, eliciting an immune response against antigens found in cells with a high self-renewal capacity and metastatic potential is critical. Cripto is specifically expressed in cancer cells with stem cell properties, so the effect of an anti-Cripto immune respon... | 4 | 0biomedical | 0Study |
263,853 | The mean of BATMOMA’s performance evaluation for succinate production is in the range of 0.41–0.55, with a standard deviation of 0.10–0.16. The mean for lactate production performance is between 0.12 and 0.22, and the standard deviation is between 0.10 and 0.25, which is close to zero. This implies that the lower the d... | 4 | 0biomedical | 0Study |
286,195 | Our observations of the directed deposition at low fluence and jets during high-fluence, multi-spot ultrafast laser ablation of stainless steel in air constitute a potentially interesting new area of research, providing a basis for further investigations to build a thorough understanding of these complex phenomena. Our... | 4 | 2other | 0Study |
167,460 | Feature pyramid networks (FPN) adopt pyramid hierarchy to collect feature information from low-level to high-level. In detail, a pair of multi-scale feature pyramids are identically constructed by upsampling and downsampling, so as to fuse features with low resolution, abundant semantic information and features with fi... | 4 | 0biomedical | 1Other |
347,964 | Given that most of the studies in this area are cross-sectional in nature, this study brings in a different perspective of diarrhea in under-5 children and health seeking behavior from a more robust study design (longitudinal);Hence a causal relationship was ascertained which is imperative in coming up with specific in... | 4 | 0biomedical | 0Study |
57,108 | Several large national initiatives will address dementia prevention in line with the 2013 G8 Dementia Summit. These draw largely on healthy or presymptomatic disease populations and offer new opportunities for systematic, prospective evaluations of people at scale, and often long-term sample biobanking, genetics, and i... | 4 | 0biomedical | 0Study |
134,490 | The matrilineal genealogical analysis showed that 82 haplotypes diverged into two main branches. One main branch contains the Heihe River G. chilianensis. Another branch contains Shule River G. chilianensis, G. przewalskii and G. eckloni which the Shule River G. chilianensis from a haplotype clade, bootstrap values wer... | 4 | 0biomedical | 0Study |
253,803 | Proteins were reduced in 10 mM dithiothreitol (Thermo Fisher Scientific) at 55 °C and alkylated in 25 mM iodoacetamide (Thermo Fisher Scientific) for 30 min at room temperature in the dark. The protein was digested with trypsin (Sigma; 100 ng) overnight at 37 °C. Digestion was quenched by adding trifluoroacetic acid to... | 4 | 0biomedical | 0Study |
52,467 | All patients followed for HD or ARM at the University Hospitals of Nantes, Angers and Paris-Necker (French center of expertise for anorectal and rare pelvic malformations) were contacted if they were aged 12 or older in April 2011. In accordance with the exclusion criteria used by Hanneman and colleagues , patients wer... | 4 | 1clinical | 0Study |
198,064 | Overall, our findings show that HTT is stabilised by interaction with HAP40 through an extensive hydrophobic interface with its distinct HEAT repeat subdomains, creating a highly stable complex. Expanded and unexpanded exon 1 remains highly dynamic in the context of this complex, sampling a vast range of conformational... | 4 | 0biomedical | 0Study |
161,312 | Triathlons involve sequential swimming, cycling and running. Only athletes with around a top 150 world ranking may compete in the World Triathlon Series (WTS), i.e., the highest level of competition below the Olympic Games. The annual WTS circuit involves up to nine races over the Olympic (OD) (1.5 km swim, 40 km bike,... | 2 | 0biomedical | 1Other |
356,262 | Several genome-wide association studies (GWASs) have been performed to identify variants associated with LDL-cholesterol levels [10–17]. However, most of these studies were conducted in European populations with a limited number in African Americans. A meta-analysis of >100,000 European individuals found 22 loci associ... | 4 | 0biomedical | 0Study |
157,297 | The RAPD analysis undertaken used the Ready-To-Go RAPD kit (GE Healthcare, Bucks, UK) with solely the RAPD Primers 2 (5′-d[GTTTCGCTCC]-3′), 5 (5′-d[AACGCGCAAC]-3′), and 6 (5′-d[CCCGTCAGCA]-3′) employed under the PCR conditions of an initial denaturation for 5 min at 95 °C, followed by 45 cycles at 95 °C for 1 min, 36 °... | 4 | 0biomedical | 0Study |
275,394 | Proper diet and the use of topical agents such as nitric acid 60% to treat onychomycosis resulted in 40% microbiological cure in the population studied, which is within the range of efficacy of other treatments. It requires limited perseverance because all patients need to visit their health professional for treatment.... | 2 | 0biomedical | 1Other |
119,345 | Cell cultures were harvested at 70% confluence and cell pellets resuspended in radioimmunoprecipitation (RIPA) assay buffer (0.1% SDS, 1% NP40 and 0.5% Na-deoxycholate in PBS) complemented with protease inhibitors (Pepstatine 5 μg/μl, PMSF 0.3 mM, Aprotinine 1 μg/μl and Sodium orthovanadate 0.1 μM). Aliquots of total p... | 4 | 0biomedical | 0Study |
59,246 | The study was part of a wider PhD in Public Health research project, to develop an application towards determining how national HRH policy interventions impact local HRH systems in peri-urban communities using Decision Space Mapping Analysis. The protocol received approval from the Academic Advisory Committee, the Rese... | 2 | 0biomedical | 0Study |
41,327 | Bioinformatic analysis of the SVBP6 genome allowed us to detect the presence of all genetic elements of a typical Gac/Rsm global regulatory cascade : a gacS gene encoding the membrane associated histidine kinase sensor, which was one of the targets of Tn5 in our mutagenesis approach (Fig 5); the gacA gene encoding the ... | 4 | 0biomedical | 0Study |
361,328 | Notch signaling has been shown to regulate distinct events in the different developmental stages of a tissue (Hartman et al., 2010; Radtke et al., 2004; Shih et al., 2012). A recent study reported that Notch activity is enriched in cTECs and that repression of Notch by HDAC3 is important for expansion/maintenance of de... | 4 | 0biomedical | 0Study |
182,747 | Immunofluorescence staining was used to detect glomerular IgG and complement C3 deposition in glomerular sections from pristane-injected and non-injected WT and TG mice. In contrast to the other groups, TG pristane-treated mice showed IgG and C3 deposits within the glomeruli, suggesting that glomerulonephritis had alre... | 4 | 0biomedical | 0Study |
23,706 | We used a linear mixed effects (LME) model of AGB observed at each census in each plot as a function of time, a categorical variable indicating whether plots were near an edge, and their interaction. The fixed effect time represents the estimate of AGB change for interior plots, and the time × edge interaction represen... | 4 | 0biomedical | 0Study |
125,340 | Breast malignancy is a rare disease in childhood; it can be a primary or a secondary neoplasm. The latter is the most common: in this case, the breast is involved as a metastatic site of different cancer originated elsewhere, such as rhabdomyosarcoma, neuroblastoma, lymphoma, or leukemia. Primary tumors, instead, arise... | 3 | 0biomedical | 1Other |
345,072 | Genetic diversity and population dynamics of begomoviruses through time were estimated using the HTS data. In this analysis, the reads were mapped to three reference databases comprising all ToMoLCV, ToSRV, and begomovirus sequences available in GenBank using BWA MEM v.0.7.17 (Li, 2013) with a seed length (-k) of 55 nu... | 4 | 0biomedical | 0Study |
109,381 | To assess which models performed best, we calculated the Mantel–Haenszel risk ratios to compare the risk of death at 6 months between patients with COPD and without COPD adjusting for predicted risk of death for the model in question. We also calculated C-statistics and Hosmer–Lemeshow goodness of fit tests. Strategies... | 4 | 0biomedical | 0Study |
260,029 | Confusion matrix: inter-rater variability. Confusion matrix for the inter-rater variability between two experienced human coders, for a video from FD. “Other Upper” and “Other Lower” represent all the upper face and lower face labels that were not part of the task of the automatic classifier. Download Figure 5-1, DOCX ... | 2 | 0biomedical | 1Other |
194,464 | [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] | 1 | 2other | 1Other |
306,600 | According to the United Nations' Convention on the Rights of the Child, adolescents should be able to enjoy the highest attainable standard of health (Article 24). 1 Their rights should be respected irrespective of their and their parents' or legal guardians' ‘race, colour, sex, language, religion, political or other o... | 1 | 2other | 1Other |
282,112 | Depending on participant preference, baseline assessment will occur face-to-face at the hospital site with a research assistant, or remotely. For participants completing baseline assessment remotely, a research team member will be available to provide support via phone call or video-conferencing software. Participants ... | 3 | 0biomedical | 0Study |
192,157 | In the current study, we investigated the neural reward processes for personal and vicarious rewards by using a false-choice gambling task while participants underwent fMRI scanning. In this vicarious reward task participants were asked to choose between two unknown distributions of resources upon which they were prese... | 4 | 0biomedical | 0Study |
206,277 | The structure of ODH, the first characterized enzyme within the ODH subclade of AA3_2 enzymes, represents a major step toward understanding the enzymatic diversity within the GOX/GDH clade as it represents the first structure of such an enzyme derived from a Basidiomycete and the second structure of a dehydrogenase fro... | 5 | 0biomedical | 0Study |
12,435 | We wanted to confirm the kinetics of daughter centriole growth using an assay that was independent of Sas-6-GFP fluorescence incorporation. Our 3D-SIM analysis of the centrioles in early D. melanogaster embryos revealed that mother centrioles are usually oriented end-on to the cortex, so they appear as hollow rings (Fi... | 4 | 0biomedical | 0Study |
322,760 | With this study, it was seen that our gamma-irradiated inactivated vaccine candidates can effectively trigger the production of SARS-CoV-2 specific antibodies along with long-term T cell response. Hence, the findings of this study prompted us to plan a new in vivo experiment with the second version of SK-01 and OZG-386... | 4 | 0biomedical | 0Study |
186,446 | A growing interest in Neuroscience-related knowledge in recent years has led to an exponential growth in the amount of related information (correct or not) made available online as well as the market for Neuroscience-related courses in Brazil. Despite this growing interest and course availability, Brazilians from all w... | 4 | 0biomedical | 0Study |
77,601 | We found seven regions of cortical thinning in BDPMDD compared to controls: (i) left insula; (ii) right middle temporal gyrus; (iii) right medial orbitofrontal gyrus; (iv) left pars triangularis; (v) left rostral middle frontal gyrus; (vi) right cuneus; and (vii) right superior frontal gyrus (all pCORR < 0.05). Compare... | 4 | 0biomedical | 0Study |
200,246 | Cox regression was used to assess time to 90-day and 1-year mortality, in relation to sBTLA on day 1–2 and day 7, with complete follow up for all patients. sBTLA was evaluated on a continuous scale, and as a binary marker (high vs. low), where the threshold concentration was defined as the nearest even concentration ab... | 4 | 0biomedical | 0Study |
129,886 | Firstly, we performed the cell mitochondrial stress test with seahorse analyzer. BMSCs or ST2 cells were induced with osteogenic or adipogenic media for 7 days and then used for Seahorse assays. Compared to undifferentiated cells, osteogenic committed hBMSCs exhibited a notable increase in the basal oxygen consumption ... | 4 | 0biomedical | 0Study |
336,159 | We will develop a data extraction sheet to guide data extraction. The sheet will be pilot-tested by two reviewers (VNN and JF) on a random sample of 05 articles and revised as needed. Two reviewers will independently read each eligible full-text article and extract the relevant data. Both sets of data will be entered i... | 2 | 0biomedical | 0Study |
88,339 | The experiment consists of four phases. In Phase 1, subjects perform 3 trials of 45 tasks. Phase 2 involves different forms of training. Subjects in the task repetition group repeat the same 45 tasks twice and with extra time. If subjects are in the synergy repetition group, eight postural synergies were derived from k... | 4 | 0biomedical | 0Study |
392,186 | The WHO has established definitive criteria for diagnosing CJD, taking into account different diagnostic modalities and variances in clinical presentations . Considering these criteria, our patient had rapidly progressive dementia along with myoclonus, nystagmus, and increased rigidity of his right side. MRI showed inc... | 4 | 0biomedical | 3Clinical case |
101,319 | The fitting process is operated by using a well-developed program by our lab. By using different trail values of unknown parameters, the theoretical phase shifts are calculated over the specified modulation frequency range. The value that gives the least square deviation between the theoretical phase shifts and the exp... | 4 | 0biomedical | 0Study |
55,227 | In the third method the stepwise regression was used. This method is useful in case of large amount of explanatory regressors (the questionnaire data subcategories in our case). Gradual draining of individual explanatory variables, for which H0:βi=0 cannot be dismissed, simplifies the regression model and identificatio... | 4 | 0biomedical | 0Study |
396,953 | In this paper we leverage the GEE platform to figure out the influence of different impact factors on forest NPP and how forests of different NPP-levels respond to climate change and short-term climate fluctuations (i.e., ENSO events), and to understand spatiotemporal dynamics of the global forest NPP and explore its r... | 1 | 2other | 0Study |
130,040 | This index is an adaptation of Gaussen aridity index (Bagnouls & Gaussen, 1953) developed by Montero de Burgos and González‐Rebollar (1974) that measures monthly soil water availability for plant as an index of plant productivity. It uses meteorological information on monthly precipitation and average monthly temperatu... | 4 | 0biomedical | 0Study |
172,344 | Rare pathogenic CNVs have also been shown to increase liability to more common mental health disorders, such as MDD. Here, short deletions (<100 kb) and known neuropsychiatric CNVs are enriched in people with depression [14•,22], and significant association has been found for 3 specific CNVs (1q21.1 duplication, PWS/AS... | 4 | 0biomedical | 0Study |
221,343 | In this study, we examined the association of maternal BV with a mothers' condition and infants' morbidities. Our analysis showed an increase in the frequency of maternal hospital admissions among women with BV compared to non-exposed subjects. In our literature review, we did not find any publication that directly rep... | 4 | 0biomedical | 0Study |
211,641 | This study shows that constitutively activating mutations of eLH/CGR (M398T, L457R, D564G, and D578Y) resulted in a significant increase in the basal cAMP production and a faster loss of the cell-surface receptor compared to wild-type eLH/CGR despite low cell-surface expression, which has been reported for mutations of... | 5 | 0biomedical | 0Study |
288,418 | The above pending Be–Te and Zn–Te issues at the term of our experimental Zn1−xBexTe Raman study at small Be content, together with the missing insight at large Be content, are tackled below by extending to high pressure the ab initio calculations on the Zn1−xBexTe supercells at x \documentclass[12pt]{minimal} \usepacka... | 4 | 0biomedical | 0Study |
157,406 | Statistical analyses indicated that the transverse and longitudinal diameters of the nuclei in Leydig cells of cryptorchid Bactrian camels were significantly increased compared to those in normal testicles (p< 0.05). The average areas of the Leydig cells were significantly larger in cryptorchid testes than in normal te... | 4 | 0biomedical | 0Study |
81,229 | Since shh is expressed in the prospective floor plate from the beginning of the notochord formation as well as in the node, we asked whether its expression is initiated prior to node and prechordal mesoderm formation. Surprisingly, chick embryos are shh positive already between stages 2 and 3 (Fig. 2a). At this stage, ... | 5 | 0biomedical | 0Study |
162,926 | Prior to the COVID-19 pandemic, telehealth was not widely used in pediatric rehabilitation settings despite numerous studies supporting its use as a feasible alternative to conventional in-person healthcare . A World Health Organization (WHO) report “Global diffusion of eHealth” from 2016 documented the use of telehea... | 4 | 0biomedical | 2Review |
203,228 | To analyze the presence of genes putatively associated with phage resistance systems, a custom database based on genes from the ‘‘PADS Arsenal database’’1 was created (Zhang et al., 2020). The genes were grouped in five systems: ABI systems related (not belonging to toxin/antitoxin system), TA systems related, R–M syst... | 4 | 0biomedical | 0Study |
211,211 | All experiments were performed on PamStation12® where up to 12 assays can be performed simultaneously (PamGene International B.V., ‘s-Hertogenbosch, North Brabant, The Netherlands). To prevent unspecific antibody binding, the PamChips® were first blocked with 2% BSA, by pumping it up and down 30 times through the array... | 3 | 0biomedical | 0Study |
230,801 | One puzzle about the commonly accepted mechanism of paclitaxel action is the issue with mitosis as the target . Unlike cells in tissue cultures, the neoplastic cells found in tumors in vivo are much less proliferative, with a doubling time significantly longer than cultured cells . At any given time, only a small fract... | 5 | 0biomedical | 0Study |
5,378 | From January 2010 to April 2014, 190 patients with newly histopathologically confirmed GBM, based on the World Health Organization criteria, who had undergone surgical resection, were selected from the electronic medical database of our institution. The inclusion criteria were as follows: (a) gross total surgical resec... | 4 | 0biomedical | 0Study |
19,559 | TC71, A4573, and SK-ES-1 cells were plated in 96 well plates in RPMI-1640 media with 10% FBS at a density of 2x104 cells per well, and were treated with 1µM WNT974 or DMSO 1:1000 as a control. After 48 hours of incubation, cells were assessed for viability with the Cell Counting Kit-8 (Dojindo Molecular Technologies, R... | 4 | 0biomedical | 0Study |
283,837 | FOREST is an academic-driven, multicenter, open-label, randomized clinical trial of fosfomycin vs ceftriaxone or meropenem (if the bacteria is ceftriaxone resistant) in the targeted treatment of bUTI caused by MDR E coli. Patients were recruited from June 2014 to December 2018 at 22 Spanish hospitals. The original prot... | 4 | 0biomedical | 1Other |
169,848 | We point out that the stimulation duration is another relevant parameter; that is particularly important when it comes to the long-lasting effects of the stimulation. While stimulation parameters such as the number of stimulation sites, the stimulation amplitude, and the stimulation frequency determine whether the stim... | 4 | 0biomedical | 0Study |
320,501 | Most reported OCC systems rely on a line of sight (LOS) path from the transmitter to the receiver. However, there are scenarios where the transmitter is not within the receiver’s FOV, for example a bookshelf blocks the transmission link between the lamp and smartphone in indoor, or two vehicles approach a cross-road in... | 1 | 2other | 1Other |
376,659 | A gas chromatography-mass spectrometry (GC-MS) approach was employed to identify pre-defined metabolites associated with the central carbon metabolism (CCM). This includes the basic energy pathways of glycolysis, the tricarboxylic acid (TCA) cycle and amino acids (AA). The comparison of the benign HOS to the malignant ... | 4 | 0biomedical | 0Study |
194,538 | Firstly, the increase of CD4 cells count at 24 months from the baseline was considered, which implies missing or lost patients before the end of follow-up period were excluded in the analysis. In that case, the total number of patient in the analysis reduced to n=334, with nR=169 and nN=165. “Observed data” will refer ... | 4 | 0biomedical | 0Study |
320,369 | The first cases of COVID-19 in CGPP implementation areas were reported between January 30 and April 5, 2020, and stigma quickly followed. Stigma impacts health education, testing, contact tracing, and even treatment for infected individuals. In India, a fruit vendor, his wife, and two adult children were the first with... | 2 | 0biomedical | 1Other |
371,375 | Cells were fixed using formaldehyde solution for the preparation DNA-protein cross-link. Chromatin fragments were obtained by application of ultrasonic sound (10 seconds each time at an interval of 10 seconds, 12 times). The supernatant was collected through centrifugation at 12000g and 4°C for 10 minutes. Thereafter, ... | 4 | 0biomedical | 0Study |
344,658 | Earlier, inhibin alpha-subunit (INHA) was found to have a tumor suppressive role in adrenocortical tumorigenesis. In INHA knockout mice, 99% developed steroid-secreting ACCs after gonadectomy . Hofland et al. (2014) investigated the methylation and expression of Inhibin α-subunit (encoded by INHA) in adrenal tumors. Th... | 4 | 0biomedical | 0Study |
173,442 | Rates of CVA/TIA were reported in all trials. Only the study from Guha reported both CVA and TIA, while the rest of the studies described only the rates of CVA. The overall stroke rate was 2.4% (264 of 11,126) compared with 2.7% (1,141 of 41,661) in the control group. Patients in the cancer group had an odds ratio of 0... | 4 | 0biomedical | 0Study |
14,044 | After the conversion from bcl to fastq format, the short reads were processed to clean up from sequencing adapters, and to filter or trim the reads for sequence quality (minimum Phred quality of 10 and minimum length of trimmed sequence of 30). Both these steps were performed with AdapterRemoval v.1.5.4 tool , after wh... | 5 | 0biomedical | 0Study |
247,284 | In regard to V. harveyi, the synthetic compounds, bithionate sodium, N,N-diethyl-M-toluamide, and 4-hexylresorcinol showed a significant bactericidal activity at increased concentrations of the strain (Table 2). The natural compounds, such as eucalyptol, garlicin 80%, monocrotaline, and pyrethrins 50%, showed a signifi... | 4 | 0biomedical | 0Study |
379,714 | Mutations in ACTG2 are the least common, with just over 20 described. Almost all of these (96%) are missense (Figure 1 and Supplementary Table S1). The expression of this γ-actin isoform is restricted to smooth muscle cells in the gut, prostate, bladder and adrenal gland. Mutations in ACTG2 cause Megacystis microcolon-... | 4 | 0biomedical | 0Study |
103,576 | Full-thickness cornea (two corneas per sample) and bulbar and palpebral conjunctiva (conjunctiva from two eyes per sample) were collected from naïve and DED mice and stored in reagent (TRIzol; Invitrogen, Carlsbad, CA, USA) at −80°C. After homogenization, RNA was isolated and reverse transcribed using an RNA purificati... | 4 | 0biomedical | 0Study |
312,281 | A total of 2,284,061 quality-filtered reads were obtained from 23 water samples (Figure 1). They grouped into 1414 protistan and 37 metazoan OTUs delineated using a cut-off value of 99% of sequence identity. The metazoans belonged to known Baikal multicellular organisms (mainly copepoda). The protistan OTUs were analys... | 4 | 0biomedical | 0Study |
365,524 | To unravel these different theories of UBC development we tested if TERT promoter mutations occur early in proposed pre-stage tissues associated with the tumor and play a role during tumorigenesis. Therefore, we analyzed TERT mutations at different known promoter nucleotide positions using a large cohort of whole-organ... | 4 | 0biomedical | 0Study |
150,797 | The total number of consultations for men in the whole period was 7,134, almost 4 times that of women, which was 2,138. The baseline level of the number of consultations for men was 193.23 at the beginning of the whole period, while it was 44.92 for women. During the pre-intervention phase, while a non-significant incr... | 4 | 0biomedical | 0Study |
322,990 | DENV 1−4 exhibited a serotype-specific response to mAb ZKA185 (Figure 2B). ZKA185 did not significantly neutralize DENV1 or DENV2 (Figure 2B). DENV3 was significantly more inhibited than DENV4 with viral inhibition occurring a 5.0 ug/ml, and 0.5 ug/ml (Figure 2B) (p = 0.003). DENV4 was significantly enhanced in the pre... | 4 | 0biomedical | 0Study |
181,969 | Other risk factors that are potentially important in explaining waste-related diseases have been discovered to play a significant role. Among other aspects, irregular waste disposal is significantly determining the incidence of being sick [25, 26]. This finding is also significant in the debate over the relative streng... | 2 | 0biomedical | 0Study |
315,037 | The observation of Mg2+ binding to the low-affinity site of N-cTnC has led to the suggestion that differences in affinity may be due, at least in part, to Ca2+ buffering, and thus, the free concentration of the ion in these experiments. Given the kinetic rates associated with these interactions, it is difficult to have... | 4 | 0biomedical | 0Study |
25,038 | Another potential barrier to the efficacy of iron fortified CF in Côte d’Ivoire is the widespread persistent low-grade inflammation caused by Plasmodium spp. (the causative agent of malaria) parasitemia that is reported to decrease iron absorption through increase in hepcidin . Previous efficacy studies with iron forti... | 4 | 0biomedical | 0Study |
55,764 | This analysis is performed on the largest single homogeneous population sample, to date. We detected most known genetic associations with common variants (MAF > 5%) using the genotyped dataset alone. For many of these associations, a weaker signal was detected using the genotyped GWAS, which became stronger in imputed ... | 4 | 0biomedical | 0Study |
354,206 | IcIgA and icIgG tended to represent the predominant isotypes in intra- and subepithelial PCs. However, there were two individuals in whom intra-/subepithelial icIgD PCs were more frequent than icIgA and icIgG PCs. Subepithelial PCs tended to be larger than the plasma cells found in GCs and exhibited more regular round ... | 4 | 0biomedical | 0Study |
135,294 | It needs to be stressed further that one of the important advantages of the gold nanodevices is their high stability with high resistance to thermal and chemical damage mechanisms. In our studies on the ultrafast optical modulation performance, we did not observe any obvious morphology changes due to strong optical irr... | 4 | 0biomedical | 0Study |
303,155 | Large clusters of wind turbines in Karnataka are located in Chitradurga and Gadag districts. We selected wind farms in these two districts for the current study (Fig. 1). Chitradurga district lies between 14.23° N and 76.39° E. We selected Vani Vilas Sagar (VV Sagar) (24.8 km2), Jogimatti hills (100.5 km2), and Challke... | 1 | 2other | 0Study |
345,744 | During foraging, bees fly back and forth several times during the day between the hive and the food location, collecting nectar/pollen and bringing it to the hive for their colony. Foraging involves highly systematic and dynamic behavioral capacities that include long distance navigation using the sun as compass, evalu... | 4 | 0biomedical | 0Study |
394,053 | Findings of the current study further indicate that most of the patients suffering from the ischemic heart diseases aged above 55 years. These findings are in line with those provided in the study of Sun according to which the incidences of stroke are frequent after the age of 55 years. Yousuf and Young further suppo... | 4 | 0biomedical | 0Study |
214,227 | CAR-T cells were generated from commercial normal donor peripheral blood mononuclear cells (PBMCs) from AllCells. The cells were further enriched from PBMC by CD3 magnetic beads (Miltenyi) and stimulated by anti-CD3/CD28 beads (Dynabeads, human T activator CD3/CD28; Life Technologies) at a 1:3 bead:T cell ratio and the... | 4 | 0biomedical | 0Study |
284,650 | Please include the following items when submitting your revised manuscript:A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.A marked-up copy of your manuscript that highlights changes made to the... | 1 | 2other | 1Other |
3,199 | The tissue samples were fixed in 4% paraformaldehyde at 4 °C and sectioned into slices. After deparaffinizing and rehydration, the sections were put into a pressure cooker for 5 min to restore the antigen in the nucleus using the citrate method. To reduce the background, H2O2 was used to suppress the endogenous peroxid... | 4 | 0biomedical | 0Study |
307,132 | For analysis of cell migration, the Oris Assembly Kit (Platypus Technologies, Madison, WI, USA) was used. Cell seeding stoppers were inserted into the wells of a 96-well plate for creating a cell-free area. 5 × 104 MDA-MB-231, 7.5 × 104 MDA-MB-468, 7.5 × 104 MCF-7, 1 × 105 SKBR-3, 1 × 105 BT-474, or 1 × 105 MCF-10A wer... | 4 | 0biomedical | 0Study |
223,645 | Borrelia burgdorferi, causative agent of Lyme disease, is a bacterial spirochete transmitted by Ixodes scapularis and Ixodes pacificus in North America . Dogs are incidental hosts for Bo. burgdorferi and not part of the transmission cycle . In North America, canine Lyme disease has been significantly associated with Bo... | 4 | 0biomedical | 0Study |
27,038 | Figure S1. Analysis of purity of primary cultured astrocytes or microglia. Primary glial cells were prepared, astrocytes and microglial cells were prepared and purified. (A1) Cells were stained with anti-CD11b-FITC antibody and detected with flow cytometry. The staining showed that < 0.1% of the cultured cells were mic... | 4 | 0biomedical | 0Study |
175,400 | ZBED6 (zinc finger, BED-type containing 6) is a transcriptional modulator that is unique to placental mammals and has evolved from a DNA transposon that integrated in an ancestor of mammals more than 200 million years ago . The fact that the DNA-binding domain of ZBED6 was found to show 100% sequence identity among 25 ... | 4 | 0biomedical | 0Study |
73,262 | In this study, we improved the sensitivity of the AAO chip by pore-area control and reduced the manufacturing time of the device compared with a previous report using hard anodization (HA). The anodizing time was reduced to by approximately 10-fold to form an aluminum oxide layer of the same thickness, provided higher ... | 4 | 0biomedical | 0Study |
131,447 | In the second scenario, participants only passed by the observation area to check whether the system would correctly recognize that none of the detected pedestrians intends to cross the street and, therefore, should not trigger any change in traffic signalization. Again, in this scenario, only one participant was simul... | 1 | 2other | 0Study |
326,364 | Differences existed in the mean scores of miners with different levels of education as follows. Miners with only a junior school education had scores that were significantly lower on E-I, M-I, S-I, and W-I than that with other miners (E-I: junior college (p = 0.004); M-I: high school (p = 0.000); junior college (p = 0.... | 2 | 2other | 0Study |
257,053 | The first group works according to the physiological principles of Moens and Korteweg , Young’s modulus of elasticity , and the Bramwell–Hill model ; the common link is the PWV, which depends on the blood pressure and blood volume flow, as well as the elasticity of the examined vessel and the viscosity of the blood. | 4 | 0biomedical | 0Study |
227,589 | Baseline clinical data on demographic characteristics, cardiovascular risk factors, cardiac symptoms and previous non-invasive exams were recorded. Follow-up was performed by reviewing medical records and telephone interviews with patients and referring physicians as needed. Additionally, vital status data was also col... | 4 | 0biomedical | 0Study |
39,016 | Cross-talk between GAs and auxins has proven to play an important role during fruit set in tomato via the activation of GA biosynthtetic enzyme GA20 oxydase by auxin (de Jong et al., 2009) two transcripts coding for GA20ox are over-expressed in compact clones (Figure 6). In grapevine crosstalk beween these two hormones... | 4 | 0biomedical | 0Study |
5,299 | Five months after sevoflurane exposure, spatial and related forms of learning and memory were assessed by MWM, as previously described (Zhang et al., 2016). Briefly, a 10-cm diameter platform was placed 1 cm above the water surface in a circular tank (diameter, 150 cm; depth, 50 cm). A flag was placed on the platform t... | 4 | 0biomedical | 0Study |
195,381 | Additionally, higher PaCO2 was an important factor for mortality. A previous retrospective study of patients with IPF in a single center yielded similar results . The present prospective study corroborated these findings among heterogenous patients waiting for transplantation, not limited to IPF. In the future, we wish... | 3 | 0biomedical | 0Study |
106,087 | The information content within MFC data revealed in a quantitative model strongly depends on the specific choices made in collecting the data and in data processing that precedes modelling. The analysed sample may consist of a relatively homogeneous cell population or can interrogate a much broader mixture of cells, su... | 4 | 0biomedical | 0Study |
205,682 | We observed an association between tobacco cigarette use before pregnancy and during pregnancy with age, which was consistent with previous studies (Schneider and Schütz 2008). However, regarding dual use, a different picture emerged, as dual use before pregnancy was not significantly associated with age. Nevertheless,... | 4 | 0biomedical | 0Study |
325,773 | To date, the underlying mechanism of CDWs in cuprates still remains elusive. Unveiling the nature of the quasistatic CDWs as well as their dynamical excitations is crucial for understanding the CDW’s origin––similar to the study of AFM in cuprates. Although the quasistatic properties of CDWs have been investigated exte... | 4 | 0biomedical | 0Study |
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