Study_ID string | Objectives string | Included string | Excluded string |
|---|---|---|---|
CRD42023483276 | Is it safe to treat atopic dermatitis with upadacitinib? A systematic review and Meta analysis of Randomized Controlled trials. | 1. Atopic dermatitis (AD) is a chronic recurring inflammatory skin disorder, which is characterized by intense pruritus and eczematous lesions. It's estimated that approximately 20% of children and 10% of adults experience this condition around the world. AD has been found to be associated with increased risk of psycho... | null |
CRD42024601798 | The protective effect of baicalin on diabetic nephropathy and its molecular mechanisms: Studies have shown that baicalin has a renal protective effect on diabetic nephropathy (DN) through its anti-inflammatory and antioxidant properties. Specifically, baicalin exerts its therapeutic effect on DN by inhibiting inflammat... | Diabetic Kidney Disease | null |
CRD42022325779 | What is 14-3-3ζ protein plays as a potential biomarker in cancer diagnosis and detection: a meta-analysis? | Cancer remains a major public health problem for humans that pose a serious threat to human health, caused a high morbidity and mortality. Although, more and more treatment methods were application in clinincal, such as surgery, chemotherapy, radiotherapy, immunity therapy, and targeted therapy, however, the outcome re... | null |
CRD420251024855 | To evaluate the effectiveness of Ayurvedic interventions (including herbal formulations, Rasayana therapy, Panchakarma, Yoga, and lifestyle modifications) on clinical and biochemical cardiovascular health outcomes such as blood pressure, lipid profile, cardiac biomarkers, echocardiographic parameters, and symptom relie... | Age: Adults aged 18 years and above. Diagnosis/Condition: Individuals diagnosed with cardiovascular diseases (CVDs) including: Hypertension Coronary artery disease Myocardial infarction Heart failure Arrhythmias Ischemic heart disease Individuals at risk of CVDs (e.g., with dyslipidemia, prehypertension, metab... | Age: Pediatric populations (under 18 years of age). Condition: Participants with non-cardiac primary conditions (e.g., renal failure, malignancies) unless cardiac parameters are specifically assessed. Co-morbid Conditions: Studies focused primarily on non-cardiovascular co-morbidities without separate analysis of c... |
CRD420250639228 | What are the factors significantly associated with treatment outcomes (e.g., 12-month seizure remission, treatment failure, drug resistance, or drug resistant epilepsy) in patients with newly diagnosed epilepsy, as identified by clinical prediction models? | Epilepsy Epilepsy is a neurological disorder that is estimated to affect 50-70 million people worldwide, defined as a predisposition towards generating unprovoked seizures. Epilepsy is more common in developing nations despite not being dependent on race, more common in males although only marginally so, and poses a hi... | null |
CRD420250651726 | What are the prevalence and risk factors of acute endophthalmitis following cataract surgery? | Acute endophthalmitis is a severe inflammation of the internal eye structures commonly observed as a postoperative complication following cataract surgery. This condition arises primarily from bacterial infections introduced during or immediately after surgical procedures. It is of particular concern due to its rapid o... | null |
CRD42025632371 | 1.Population (P): The primary question is whether acoustic stimulation (e.g., white noise, music therapy) can reduce symptoms of primary insomnia in comparison to a placebo, no intervention, or other treatment modalities.
2.Intervention (I): What types of acoustic stimulation interventions (e.g., white noise, music, or... | This systematic review and meta-analysis will focus on insomnia, a common sleep disorder characterized by persistent difficulty in falling asleep, staying asleep, or waking up too early, despite having the opportunity to sleep. Insomnia can lead to daytime impairment such as fatigue, mood disturbances, and reduced qual... | null |
CRD42022336683 | Which therapeutic class of drugs has the most efficacious control of postoperative pain intensity in adult patients undergoing periodontal surgery? | Postoperative pain control after periodontal surgery. | null |
CRD42024533367 | What is the impact of the Pharmaceutical Consultation in terms of detecting and mitigating problems related to effectiveness and safety, management capacity, adherence, and experience regarding medication, in cancer patients receiving therapy with oral antineoplastics agents, compared to a conventional model of medicat... | This Systematic Review aims to study the impact of Pharmaceutical Consultation on oncology outpatients receiving therapy with oral antineoplastic agents. Therapeutic protocols in oncology are generally complex, often composed of multiple medications with highly variable dosages. Unlike intravenous therapies administere... | Pharmaceutical consultations conducted outside a hospital pharmacy setting. |
CRD42025632683 | To assess therapeutic effect and the safety of the acupuncture jiaji treatment for the patients with cervical spondylosis of vertebral artery type. | Vertebral artery type cervical spondylosis is a common type of cervical spondylosis. Due to the compression of the vertebral artery and insufficient blood supply of the vertebrobasilar artery, the main clinical manifestations are paroxysmal headache and dizziness in the nape and occipital regions, accompanied by tinnit... | null |
CRD42025648578 | In adult patients undergoing peripheral intravenous (PIV) insertion in preoperative settings (P), how do various anxiety-reducing techniques—including pharmacological, non-pharmacological, distraction, cognitive-behavioral, technological, and skill-enhancement interventions (I)—compared to standard care without specifi... | • Primary Outcome: Reduction in patient-reported anxiety (measured via validated scales such as VAS-Anxiety, STAI).
• Secondary Outcomes:
o Changes in physiological markers of anxiety (e.g., heart rate, blood pressure).
o Impact on procedural success (e.g., first-attempt success rate, overall insertion time). | null |
CRD42024554006 | This study intends to use the method of meta-analysis, hoping to answer the following questions:
1. Is Information Technology effective for social-emotional competence in people with autism?
2. What factors affect the effectiveness of Information Technology interventions? | Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterized by impairments in social interaction and repetitive stereotyped behaviors. The prevalence of ASD is increasing. According to the weekly report released by the Centers for Disease Control and Prevention (CDC) in April 2023, by 2020, ... | null |
CRD42024553610 | There is a lack of accurate biomarkers for diagnose and prognosis assessment of interstitial lung disease(ILD). Visual recognition is still used to diagonse and predict the prognosis of ILD patients in clinical practice.Radiomics is a high-throughput mining of quantitative image features for standard medical imaging, w... | Interstitial lung disease (ILD) consists of a group of pulmonary disorders characterized by inflammation and/or fibrosis of the lung parenchyma associated with progressive dyspnea that frequently results in end-stage respiratory failure. | null |
CRD420251004591 | The purpose of this systematic review and meta-analysis is to evaluate the prognostic impact of irradiation in addition to systemic chemotherapy for stage IVB cervical cancer. In particular, we will evaluate whether the combination of molecularly targeted agents and immune checkpoint inhibitors has an impact on treatme... | Cervical cancer patients with metastasis. Stage IVB (FIGO 2018) Chemotherapy; Chemoradiotherapy; Radiotherapy To Pelvis; Immunotherapy Patients who have received systemic chemotherapy (including molecular targeted drugs and immune checkpoint inhibitors) and pelvic radiation therapy. PICO tags selected: Chemotherapy; Im... | null |
CRD42018114257 | 1. The primary aim is to evaluate the diagnostic performance of 68Ga-PSMA PET/CT for detecting relapse or metastasis in prostate cancer patients with biochemical failure after primary treatment?
2. The secondary aim is to assess the potential impact of 68Ga-PSMA PET/CT on the treatment strategy of prostate cancer patie... | Prostate cancer patients with biochemical failure after primary treatment | null |
CRD42025641946 | What is the effect of therapeutic doses of methylphenidate on reducing apathy in patients diagnosed with Alzheimer’s dementia, compared to placebo or no intervention, as measured by standardized apathy scales in randomized controlled trials (RCTs)? | Alzheimer's dementia is a progressive neurodegenerative disorder and the most common cause of dementia worldwide. It is characterized by cognitive decline, memory impairment, and a range of neuropsychiatric symptoms, including apathy. Apathy is a prevalent and debilitating symptom in Alzheimer’s patients, defined as a ... | null |
CRD420250644594 | In patients diagnosed with systemic sclerosis (or CREST syndrome or VEDOSS), how does blood immune cell phenotyping by cytometry serve as a prognostic and/or predictive marker compared to healthy controls and/or other autoimmune disease patients? | Systemic Sclerosis Systemic sclerosis is a rare chronic autoimmune connective tissue disease characterized by fibrosis of the skin, joints and internal organs, and by vascular abnormalities. Its course is unpredictable, and there is no specific treatment to date. Adults with systemic sclerosis, lcSSc, dcSSC, VEDOSS, CR... | Patients under the age of 18, patients with localized scleroderma or morphea, animals subjects. Studies using other technological approach than mass or flow cytometry. Studies exclusively reporting cytometry data of tissues other than blood. Groups of patients with autoimmune diseases without separate data on SSc patie... |
CRD420250600819 | (1) Are digital physiotherapy interventions associated with better pain, physical function and quality of life outcomes, when compared to physiotherapy care with no or minimal digital components? (2) Which digital platform or/and component of intervention yields the best clinical outcomes? (3) How long can the above-me... | Knee osteoarthritis ; Digital intervention; Physiotherapy Knee osteoarthritis (OA) is a degenerative joint disease which leads to the damage of articular cartilage, bone osteophyte formation, sclerosis of the subchondral bone, affecting predominantly 3 components of the knee joint, including medial lateral and patellof... | Exclusion criteria: Participants who had, or were on waiting list for knee surgery Exclusion criteria: passive care, such as being on waiting lists; purely medical care, such as medication or surgery. |
CRD42024499966 | Is there a difference in the viability of stromal vascular fraction cells (SVF) in between the cryopreserved and freshly isolated adipose tissue? | The viability of stromal vascular fraction (SVF) cells within adipose tissue remains intact across various freezing temperatures. Adipose tissue is recognized for its efficacy as a grafting tool, primarily attributable to the pluripotent regenerative capabilities of SVF cells. Cryopreservation plays a crucial role in e... | null |
CRD42025631153 | Participants: Participants were rheumatoid arthritis patients who met the diagnostic criteria, regardless of age or gender.Intervention: The treatment group was given bee acupuncture or bee acupuncture combined with conventional western medicine.Comparison: The control group was treated with conventional western medici... | Rheumatoid arthritis (RA) is a common rheumatic immune disease in clinical practice. It often occurs in the small joints of hands and feet and presents with symmetrical attacks. The main manifestations are pain, swelling and functional disorders of the affected joints, and it is prone to recurrence. The global incidenc... | null |
CRD420251014877 | What is the efficacy, safety, and impact on quality of life of pharmacological interventions compared to placebo, standard of care, or any other active comparators in adults diagnosed with Polycythemia vera? | Adult patients (≥18 years) diagnosed with Polycythemia vera (PV). Ruxolitinib; Peginterferon Alfa-2b; Interferon Alfa; Recombinant Interferon Alfa-2b; Hydroxyurea; Aspirin Fedratinib, Momelotinib, Pacritinib, Rusfertide, Sapablursen, Divesiran, Vamifeport, Givinostat, Bomedemstat PICO tags selected: Placebo This review... | Pediatric populations (<18 years), patients with diseases other than Polycythemia vera, mixed myeloproliferative neoplasms (MPNs) where data specific to PV cannot be extracted, or co-diagnosis with other hematological malignancies (e.g., essential thrombocythemia, myelofibrosis). Patients who have not received pharm... |
CRD42024578558 | What is the effectiveness of laser auriculotherapy in managing musculoskeletal pain compared to other conventional treatment methods?
PICOS approach
Population: Individuals with musculoskeletal pain or musculoskeletal disorders
Intervention: laser auriculotherapy
Comparison: Other interventions, placebo, or sham
Primar... | Musculoskeletical pain or musculoskeletal diseases
Musculoskeletical pain: discomfort stemming from muscles, ligaments, tendons, and bones (year introduced:
2012). MeSH (Medical Subject Headings)
Musculoskeletal Diseases:Diseases of the muscles and their associated ligaments and other connective
tissue and of the bones... | null |
CRD42025649170 | General Review Questions
What are the primary pathogenetic mechanisms linking smoking and smokeless tobacco use to oral squamous cell carcinoma (OSCC)?
How do the carcinogenic compounds in smoking and smokeless tobacco contribute to OSCC at the molecular and cellular levels?
What are the differences in the pathophysiol... | Oral squamous cell carcinoma is a type of oral cancer that develops within the thin squamous cells that line your mouth and throat. It may appear as slow-growing skin lesions that may ulcerate and cause scarring of the oral cavity, making it difficult to eat, swallow food, or even to speak. The treatment of choice is a... | null |
CRD42021236702 | This meta-analysis aims to evaluate the efficacy and safety of berberine alone for several metabolic disorder disease. We also evaluate the factors which may influence the therapeutic effect base on subgroup analysis. | Metabolic activity is the basic life activity of the human body and the fundamental for maintaining body functions. With the improvement of living standards, the incidence of metabolic disorder diseases is also increasing year by year. Most metabolic disorder diseases lack a radical cure, and the existing treatment mea... | null |
CRD42024612967 | Primary Question: Which is the evidence that immune-mediated adverse reactions (allergies) are caused by ingestion of peas and derived ingredients?
Secondary Question: Which pea protein molecules are recognized by the immune system in individuals and are responsible for causing IgE-mediated allergies to peas and deri... | The condition being studied is a food allergy, specifically relating to the ingestion of peas. Food allergies occur when the immune system mistakenly targets certain food proteins. Symptoms can range from mild reactions, like hives or gastrointestinal discomfort, to severe and potentially life-threatening responses suc... | null |
CRD42023417259 | To evaluate the efficacy and safety of " Earth-banking up to Generate Metal" Method in Chinese Herbal Medicine in treatment of stroke-associated pneumonia(SAP) by using Bayesian network meta-analysis | Stroke-associated pneumonia (SAP) is a common poststroke complication with a prevalence rate of 11.3–31.3%. Despite remarkable advances in the care of acute stroke patients, the outcomes of SAP are still poor, including prolonged hospitalisation, high incidence of severe disability, and high in-hospital mortality rate.... | null |
CRD42024555765 | The aim of this study is to assess the efficacy of Traditional Chinese Medicine decoction in promoting the recovery of gastrointestinal function in postoperative patients with Colorectal Cancer through systematic evaluation and Meta-analysis. We will include Randomised controlled trials comparing Traditional Chinese Me... | This study aims to investigate gastrointestinal dysfunction following Colorectal Cancer. In recent years, the morbidity and mortality of malignant tumors have continued to rise globally. Surgery is a common treatment for Colorectal Cancer. However, anesthesia, surgical straining, inflammatory stimulation, and prolonged... | null |
CRD42022379713 | What is the estimated 1-year mortality rate after cardiac stereotactic body radiation therapy for refractory ventricular arrhythmias? | Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder that can result in sudden cardiac death. Radiofrequency catheter ablation is the current state-of-the-art treatment for drug refractory VT. However, patients with failed catheter ablations or contra-indicated to the procedure have poor prognosis i... | null |
CRD42023414499 | The aim of this realist review is to develop a program theory that explains: -
i. The causal mechanisms by which the symptomatic management of breathlessness might be improved using hypnotherapy interventions.
ii. The contextual factors outside of the hypnotherapy intervention that these mechanisms may interact with to... | Hypnotherapy Interventions , Chronic Conditions with Breathlessness as a Symptom | null |
CRD420250605060 | What is the predictive accuracy and clinical utility of machine learning models that incorporate pre-procedural clinical and radiological data in forecasting favourable outcomes (defined as a modified Rankin Scale score ≤ 2 at 90 days) for patients with large vessel occlusion (LVO) undergoing endovascular thrombectomy ... | Thrombectomy; Endovascular Revascularization This systematic review focuses on acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). The healthcare domain involves the predictive performance of machine learning (ML) models in forecasting clinical outcomes for patients undergoing endovascular thrombectomy ... | Studies not focused on AIS with LVO or not using ML models for post-thrombectomy outcome prediction. Studies without mRS score reporting or using intra/post-procedural data in ML models. Review articles, meta-analyses, editorials, case reports, abstracts, conference presentations, or studies without full-text availabil... |
CRD420251003754 | A network meta-analysis was conducted to indirectly compare the efficacy and safety profiles of Dupilumab, Mepolizumab, Tezepelumab, and Omalizumab, providing evidence-based insights to optimize individualized therapeutic decision-making for patients with heterogeneous inflammatory endotypes. | Adult patients (≥18 years old and of both sexes) with CRSwNP Dupilomab ; Omalizumab; Mepolizumab; Tezepelumab; Monoclonal Antibodies Monoclonal antibodies (omalizumab, dupilumab and mepolizumab, tezepelumab) used for the treatment of chronic rhinosinusitis with nasal polyposis PICO tags selected: Placebo | Adolescents (under 18 years of age) and elderly people (over 70) |
CRD420250648714 | The effectiveness and safety of targeted nucleic acid delivery mediated by lipid nanoparticles (LNP) of various configurations for the tumor size reduction and median survival time of malignant liver tumors in murine models compared with placebo. | The models of liver malignant neoplasms C57BL/6 and BALB/c mice, 4-8 weeks old LNP-mediated nucleic acids antitumor therapy; LNPs in different formulations, dosage; duration and frequency of LNP administration | other age, other species usage of other vectors and therapeutic agents absent of control or other |
CRD420250641766 | A. Primary research question(s):1. What is the association between PON1 gene polymorphisms and the risk of developing Type 2 Diabetes Mellitus (T2DM) and related complications?2. How do PON1 polymorphisms influence oxidative stress and related complications in T2DM patients?3. What is the impact of specific PON1 polymo... | Type 2 Diabetes Mellitus; Genetic Polymorphism; Complication In this study, the population includes individuals with diabetes. Exposure with the PON1 gene, and the expected outcome is to understand whether this gene increases the risk of developing type 2 diabetes. The liver synthesizes the PON1 enzyme, which is critic... | 1. Population: Studies focusing on individuals diagnosed with conditions other than Type 2 Diabetes Mellitus (T2DM), such as Type 1 Diabetes, gestational diabetes, or non-diabetic populations. 2. Interventions/Exposure: Studies that do not examine PON1 gene polymorphisms or focus on other genetic variants unrelated to ... |
CRD42024612487 | Stroke is the leading cause of disability and death in Chinese adults, and most people with this condition are left with upper extremity motor deficits and adverse effects. There is a well-established paradigm for the treatment of upper extremity motor dysfunction using a combined central-peripheral therapeutic modalit... | Stroke is a clinical condition caused by cerebrovascular disease that can result in focal (or global) brain tissue dysfunction lasting more than 24 hours or leading to death. Most stroke patients still have different degrees of limb motor dysfunction after rehabilitation, and upper limb dysfunction is more severe than ... | null |
CRD420250640198 | To assess whether using the PD-1/PD-L1 inhibitors can enhance the improvement of clinical symptoms and survival rate in patients with thyroid cancer | Thyroid Cancer; Monoclonal Antibodies; Anti-PD-1 antibodies; Anti-PD-L1 antibodies; Symptom Management "Thyroid cancer is a malignancy originating from the thyroid gland, which is one of the most common endocrine cancers worldwide. It includes several subtypes, such as papillary, follicular, medullary, and anaplastic t... | null |
CRD420250594439 | General objective: | Skeletal Malocclusion; Malocclusion, Angle Class III; Machine learning; Artificial intelligence Craniofacial anomalies: class III skeletal malocclusion Inclusion criteria:Population from 6 to 65 years old, diagnosed with skeletal class III. Diagnosis from artificial intelligence tools: interpretation of medical images ... | Exclusion criteria: population with a history of trauma in the craniofacial region, patients with growth disorders, syndromic patients with the presence of asymmetry related to the syndrome, individuals with craniofacial anomalies. |
CRD420251009928 | This study will define the microbial ecology and co-occurrence patterns of microorganisms in subgingival plaque in cases of peri-implant mucositis and periimplantitis identified by both conventional/cultural analysis and molecular methods. | Population will include studies in which: 1. The diagnosis of peri-implant mucositis and peri-implantitis as defined by the diagnostic criteria established in the 2017 World workshop; 2. Sequencing or robust culture methodologies (including aerobic and anaerobic culture) have been employed to define the microbiota of t... | The main exclusion categories will be studies in which 1. The diagnosis of peri-implant mucositis and peri-implantitis is not defined by all of the diagnostic criteria established in the 2017 World workshop 2. The study was undertaken before 2017 3. Sequencing or robust culture methodologies (including aerobic and anae... |
CRD420250632333 | his study aims to investigate the changes in gut microbiota in benign prostatic hyperplasia. | Benign prostatic hyperplasia (BPH) is a common male urological problem worldwide. These conditions pose a heavy economic burden on society and can lead to lower urinary tract symptoms in men, such as frequent urination, urgent urination, nocturia, hesitancy in urination, and reduced urine volume. The gut microbiota is ... | null |
CRD420251025757 | Primary Question: | Inclusion: Adult humans (≥18 years) with or without metabolic disorders (e.g., obesity, type 2 diabetes, metabolic syndrome). Exclusion: Animal studies, pediatric populations, in vitro studies Any form of A. muciniphila (probiotic, pasteurized, or FMT-derived). PICO tags selected: Placebo no intervention, or other pro... | • Animal or in vitro studies. • Case reports, reviews, or conference abstracts without full data. Adolescents (under 18 years of age) and elderly people (over 70). PICO Framework: • Population (P): Adult humans (≥18 years) with or without metabolic disorders (obesity, type 2 diabetes, metabolic syndrome, NAFLD). • Inte... |
CRD420250375725 | Primary Question:
What are the injury mechanisms, clinical characteristics, imaging findings, and prognostic outcomes in children and adolescents with spinal cord injury without radiologic abnormality (SCIWORA)?
Specific Sub-questions:
What are the most common injury mechanisms (e.g., sports injuries, traffic accidents... | The condition being studied in this systematic review is **Spinal Cord Injury Without Radiologic Abnormality (SCIWORA)** in children and adolescents. SCIWORA is a rare but serious spinal cord injury characterized by clinical signs of spinal cord dysfunction without evidence of fractures or dislocations on standard radi... | null |
CRD420251017179 | To systematically evaluate the efficacy and safety of neuromodulation therapies for individuals with Autism Spectrum Disorder (ASD), compared to sham stimulation or standard care. Specifically, the review aims to: | Individuals of any age diagnosed with Autism Spectrum Disorder (ASD) based on recognized diagnostic criteria (e.g., DSM-5, ICD-10, ADOS, or ADI-R). Participants undergoing neuromodulation therapies, including but not limited to transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), or ... | Studies focusing solely on individuals with other primary neurodevelopmental or psychiatric disorders (e.g., ADHD, schizophrenia) without a confirmed ASD diagnosis. Animal studies, case reports, conference abstracts, reviews, or protocols without full outcome data. Studies not reporting clinical, behavioral, or cogniti... |
CRD42024516520 | A Study on Therapeutic Impact and Safety Profile of Hypoxia-Inducible Factor Stabilizers for Kidney Disease-Related Anemia in Patients undergoing dialysis and Patients who are not receiving dialysis. | The systematic review focuses on kidney disease-related anemia in patients undergoing dialysis and those not receiving dialysis. The study examines the therapeutic impact and safety profile of Hypoxia-Inducible Factor (HIF) stabilizers, specifically exploring their effectiveness and safety in the treatment of anemia as... | null |
CRD42023450441 | Is this ipsilateral acupuncture more effectiveness than contralateral acupuncture? | Several studies have indicated that acupuncture treatment regulates the pain modulator system and chronic
pain.
Acupuncture can be performed on the affected side of the patient, which is ipsilateral acupuncture, in which
the needle is on the same side as the patient's complaint. Or contralateral acupuncture may be perf... | null |
CRD420251031557 | This systematic review aims to evaluate the efficacy and safety of laser-assisted drug delivery (LADD) for the treatment of vitiligo when used in combination with topical therapies. | Inclusion Criteria: Patients of any age with a clinical diagnosis of any subtype of vitiligo (segmental, non-segmental, generalized, acral, etc.). Laser therapy; Low Level Laser Therapy; Diode Laser; Laser Surgery; Femtosecond Pulsed Laser; Laser Resurfacing Of Skin; Carbon Dioxide Laser; Erbium Yttrium Aluminum Garnet... | Exclusion Criteria: Non-vitiligo patients, Animal studies, non-human models. Use of lasers without follow-up topical therapy. Phototherapy-only protocols (e.g., excimer laser alone). Studies using microneedling or dermabrasion for delivery instead of laser. Systematic reviews, meta-analyses, editorials, commentaries, a... |
CRD42022383032 | This study aimed to clarify the efficacy of the combined treatment regimens involving PARP Inhibitors and novel hormonal agent and provided certain reference for clinical drug treatment in refractory metastatic prostate cancer patient with different homologous recombination deficiency status. | metastatic castration-resistant prostate cancer | null |
CRD42024581574 | What is the effectiveness and Safety of Acupuncture when used alongside conventional treatment in managing pneumonia? | Pneumonia; Lower Respiratory Tract Infection; Acupuncture; Electroacupuncture Pneumonia is a lung infection that causes inflammation in the parenquima pulmonar , which can lead to the accumulation of fluid or pus, making it difficult to breathe leading to a disruption of normal gas exchange causing symptoms like cough,... | null |
CRD420250641501 | Does the use of albumin in critically ill patients provide significant clinical outcomes over alternative treatments, considering its cost-effectiveness and potential for inappropriate use? | Use of albumin in critically ill patients for resuscitation, management of hypoalbuminemia, and as a replacement fluid during therapeutic plasma exchange. Adult ICU patients (≥18 years) receiving albumin for resuscitation, hypoalbuminemia management, or plasma exchange. Administration of human albumin in critical care ... | pediatric patients, patients outside intensive care, potential organ donors |
CRD42025630528 | What is the prevalence of sarcopenia among patients with hip fractures, and what are the independent risk factors associated with the development of sarcopenia in this patient population? | This systematic review focuses on sarcopenia in patients with hip fractures. Sarcopenia is an age-related loss of muscle mass and function that increases the risk of falls and fractures, particularly among those with hip fractures. This condition not only affects patients' recovery and quality of life but also leads to... | null |
CRD42024593173 | Population (P): Patients with Knee Osteoarthritis (KOA)。Intervention (I): Traditional Chinese Exercises（Description: This includes but is not limited to Tai Chi, Qigong, Yijinjing, and other traditional Chinese practices.）。Comparison (C): No intervention or alternative interventions。Outcome (O): Gait-related parameters... | Knee osteoarthritis (KOA) is a prevalent degenerative joint disease that impairs mobility and quality of life in the elderly population. It manifests through joint pain, stiffness, and functional limitations, particularly affecting the gait mechanics. Traditional Chinese exercises, such as Tai Chi, Qigong, and Yijinjin... | null |
CRD420250648844 | Among people diagnosed with anxiety or depression, is chromotherapy effective in reducing symptoms compared to no treatment or other interventions?"+If effective, what is the magnitude of the reduction in anxiety and depression symptoms attributed to chromotherapy? | Chromotherapy is an integrative and complementary health practice that uses wavelengths in the visible spectrum to promote well-being and treat various medical conditions. As a millennia-old practice, chromotherapy has been referenced in ancient civilizations such as the Egyptian, Chinese, and Indian cultures (Azeemi e... | null |
CRD420250654634 | What are the effects of whole-body vibration in individuals with chemotherapy-induced peripheral neuropathy?What are the outcomes of this intervention in these individuals? | Chemotherapy-induced peripheral neuropathy; Cipn - Chemotherapy-induced Peripheral Neuropathy Peripheral neuropathy is a manifestation of neurotoxicity considered one of the adverse effects of chemotherapy treatment. Chemotherapy-induced peripheral neuropathy develops due to the neurotoxicity of chemotherapy agents use... | null |
CRD420250644776 | People who experienced DISH with metabolic triggers, including obesity, diabetes, and other metabolic conditions. | People with Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Metabolic Disturbances Such as Obesity, Hypertension, Diabetes, and Dyslipidemia People who experienced DISH with metabolic triggers, including obesity, diabetes, and other metabolic conditions. patients with Diffuse Idiopathic Skeletal Hyperostosis (DISH)... | conditions other than DISH (e.g., other causes of spinal ligament calcification or ossification |
CRD42018089928 | A quantitative review of the patient characteristics (tumour type, age and sex) represented in interventional studies of depression in adults with cancer. | Depression in people with cancer. | null |
CRD42024575485 | 10.Nowadays, due to the use of barbiturates, non-steroidal anti-inflammatory drugs and opioids. A large proportion of migraine patients are Under great economic pressure.According to the epidemiological survey and long-term drug treatment can lead to a variety of adverse events, seriously affecting patients’ normal lif... | migraine is a clinical refractory disease,, which can be caused by various causes and is a disease with a high incidence. According to the relevant literature reports, the annual prevalence of migraine in various countries ranges from 3.3% to 32.6% in women and 0.7% to 16.1% in men.migraine is difficult to cure clinica... | null |
CRD42021272896 | The therapeutic options for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have expanded rapidly over the last 5 years. Bruton tyrosine kinase (BTK) inhibition with tyrosine kinase inhibitors (TKIs) including ibrutinib, acalabrutinib, and zanubrutinib have emerged as the recommended frontline treatme... | Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world, most commonly affecting older adults and males. CLL/SLL has a variable prognosis and disease course. Treatment options for CLL, including the BTK inhibitors, have been rapidly expanding in the last decade. | null |
CRD420250656117 | In in vivo and in vitro models, do parasitic infections contribute to cancer development, or do they provide protective effects against cancer, compared to uninfected models? | Parasitic infection; Cancer; Carcinogenicity This review examines the impact of parasitic infections on cancer, focusing on their potential carcinogenic and protective effects. It explores evidence on how various parasites, including Schistosoma haematobium, Trypanosoma cruzi, and Echinococcus granulosus, can influence... | null |
CRD42020102723 | Extravasation of contrast in hemorrhagic contusions is a predictor of expansion, mortality and poor prognosis in trauma? | Traumatic brain injuries are the leading cause of death in trauma victims and cause high rates of neurological sequelae. Several factors such as concomitant coagulopathy, need for cardiopulmonary resuscitation, advanced age, multiple hematomas, midline deviation, surgical decompression procedures, initial lesion size, ... | null |
CRD420251022388 | How effective is lifitegrast in improving the clinical signs and symptoms of DED? | Topically administered lifitegrast ophthalmic solution Placebo or carboxymethylcellulose (CMC) 0.5% | Standard treatments (artificial tears, topical steroids, and cyclosporin), placebo, or any other biologic or immuno-modulating drug Any other conventional or nonconventional therapy for DED |
CRD420251016089 | By comparing the effects of different techniques, therapists can develop the most suitable treatment plan for each patient and gain insights into the strengths and weaknesses of various methods, aiding in the selection of the most appropriate approach based on the patient's symptoms and needs. Additionally, the use of ... | Inclusion: Maitland techniques improve joint range of motion and pain through graded mobilization, making them suitable for early-stage OA and patients with joint stiffness. Exclusion: Adolescents (under 18 years of age) and elderly people (over 70). include the exclusive or combined application of Maitland or Mulligan... | null |
CRD420251011415 | In this study, the effectiveness of different integrated Chinese and western medicine therapies will be ranked through network meta-analysis, so as to provide scientific evidence-based medicine for the best clinical choice. | All adult patients are diagnosed as spastic paralysis after ischemic stroke. There will also be no restrictions based on gender, race, and the course of the disease. Patients receiving different integrated Chinese and Western therapies Patients receiving only one of Chinese medicine or Western medicine | null |
CRD420250640444 | 1. What is the effectiveness of educational interventions in improving nurse-family communication in NICU settings?2. What are the key components, processes, and theoretical underpinnings of nurse-family educational interventions in NICU settings?3. What are the gaps in the current literature regarding nurse-family com... | To review existing research on educational interventions that improve communication ability between NICUnurses and families. Inclusion Criteria• Primary empirical research published between 2014 and 2024.• Studies published in English.• Peer-reviewed journal articles• Quantitative, qualitative, and mixed-methods design... | null |
CRD42022337700 | Over the last decade, many studies have published comparisons of different treatment options on FP-ISR. But because of a shortage of high-grade evidence to guide clinical practice, so this Bayesian network meta-analysis was conducted to explore which treatment is the most optimal strategy for FP-ISR. | Femoropopliteal artery in-stent stenosis (FP-ISR) has been reported in approximately 20% to 40% of patients who treated with bare metal stents (BMS) within 1 year of treatment. Restenosis tends to be diffuse and correlate with the length of stented segment, vessel diameter and the presence of stent fracture.what’s more... | null |
CRD42024602303 | The review seeks to explore the role of food bioactive compounds in the treatment of breast and prostate cancer by addressing three specific questions:
What is the role of food bioactive compounds in the treatment of breast and prostate cancer?
This question investigates the therapeutic effects of bioactive compounds s... | This systematic review focuses on breast and prostate cancer, two of the most prevalent malignancies worldwide.
Breast cancer is the most common cancer among women, characterized by the uncontrolled growth of breast cells. It can spread to other parts of the body and is influenced by factors such as genetics, hormones,... | null |
CRD420251015579 | To conduct a systematic review on the impact of dapagliflozin on the progression of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) with preserved and mildly reduced ejection fraction, with and without type 2 diabetes mellitus. | Adult patients with chronic heart failure and chronic kidney disease. Dapagliflozin Placebo 1. Clinical studies involving patients with chronic heart failure with preserved and mildly reduced ejection fraction, as well as renal insufficiency. 2. Clinical studies comparing dapagliflozin with placebo. 3. Clinical studies... | Other SGLT2 inhibitors Other comparators 1. Studies comparing other drugs. 2. Studies analyzing other outcomes (e.g., biomarkers). 3. Studies involving surgical interventions or post-surgical treatments. 4. Cohort studies, case-control studies, expert opinions, and conference materials. 5. Review articles. 6. Studies n... |
CRD42024598341 | The aim of this meta-analysis of randomized controlled trials is to systematically evaluate the clinical efficacy and safety of Buyang Huanwu decoction in the prevention and treatment of atherosclerosis. | Atherosclerosis is a pervasive cardiovascular condition characterized by the accumulation of lipids, complex carbohydrates, blood proteins, calcium, and cellular waste products in the arterial wall, leading to luminal narrowing and potential vessel rupture. The epidemiological data indicates that atherosclerotic cardio... | null |
CRD42024602866 | To systematically evaluate the effect of combined or alone Seminar teaching versus lecture-based learning (LBL) in surgical clinical teaching for Chinese medical students. | Surgery is a crucial component of the clinical curriculum and an essential therapeutic approach for various diseases. In recent decades, modern surgery has experienced significant advancements, with continuous innovations in technologies and pharmaceuticals. Relying solely on lecture-based learning (LBL) no longer sati... | null |
CRD42020151037 | To compare the efficacy of different targeted temperature management for mild hypothermia after cardiopulmonary resuscitation | After cardiopulmonary resuscitation, the efficacy of mild hypothermia therapy has been widely accepted, but the targeted temperature management of mild hypothermia is still controversial. At the beginning, it was usually set to be less than 32℃. Later, it was found that 33℃ can also achieve good therapeutic effect. Now... | null |
CRD42024554468 | This meta-analysis mainly analyzes the therapeutic effect of traditional Chinese medicine on retinal pigment degeneration, evaluates its effectiveness and clinical practicality | Primary retinitis pigmentosa (RP), also known as blanket retinal degeneration, is a progressive, hereditary, and malnourished degenerative disease characterized by chronic progressive visual field loss, night blindness, pigmentary retinopathy, and abnormal electroretinogram, ultimately leading to decreased vision. Trad... | null |
CRD420250604888 | The aim is not only to summarize the scientific evidence on the efficacy and safety of this revolutionary option in the treatment of absolute uterine infertility, but also to examine maternal and neonatal outcomes and identify challenges and future perspectives. | Female Infertility; Primary Uterine Infertility; Secondary Uterine Infertility Women diagnosed with absolute uterine factor infertility, that is, infertility that is completely attributed to the absence (congenital or acquired) or abnormality (anatomical or functional) of the uterus. Uterine malformations affect approx... | null |
CRD420250653643 | Primary Questions: | Breast Cancer Adult patients diagnosed with breast cancer (any subtype or stage) Delayed treatment Delay in treatment initiation or in multimodal treatment (Surgical, chemotherapy, radiotherapy, immunotherapy) PICO tags selected: Usual Care; Delayed treatment Early vs. delayed treatment | null |
CRD42024512886 | On the basis of randomized control trials, what are the efficacy and safety profiles of nifurtimox and benznidazole in adults with seropositive indeterminate phase Trypanosoma cruzi infection? | Efficacy and safety profile of nifurtimox and benznidazole treatment for indeterminate phase Chagas disease in adults. | null |
CRD420251022707 | 1. To present a rare case of SAPHO syndrome with mandibular involvement and TMJ ankylosis managed with custom fitted alloplastic total joint replacement. | Patients with SAPHO syndrome having mandibular involvement, chewing difficulty, pain, TMJ ankylosis with or without any definitive management. Total Prosthetic Replacement Of Temporomandibular Joint; Antibiotic Therapy; Non-steroidal Anti-inflammatory Drug; Steroid therapy; Hyperbaric Oxygen Therapy; Decortication; Bis... | null |
CRD420250645720 | This study aims to investigate the complete remission (CR), overall survival (OS), disease-free survival (DFS), and event-free survival (EFS) of newly diagnosed adult patients with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph+ B-ALL) treated with tyrosine kinase inhibitors (TKIs) (imatinib, ... | Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia; Tyrosine kinase inhibitor Leukemia All eligible studies will follow the PICO criteria: (i) patients: newly diagnosed B-cell Ph-positive ALL, (ii) intervention: TKI plus chemotherapy regimens, and (iii) outcomes: data on survival outcomes, responses, and tre... | null |
CRD420250641637 | Primary Question:What is the diagnostic and prognostic utility of tear biomarkers in non-infectious uveitis and other inflammatory eye diseases?Secondary Questions:Which tear biomarkers have been studied in non-infectious uveitis and other inflammatory eye diseases?What methods are used to detect and quantify tear biom... | The study focuses on the diagnostic and prognostic utility of tear biomarkers in non-infectious uveitis and other inflammatory eye diseases, including their role in disease activity monitoring, treatment response evaluation, and understanding pathophysiological mechanisms. Participants include individuals diagnosed wit... | Exclusion Criteria: Studies focusing solely on aqueous or vitreous biomarkers without tear analysis. Animal studies. Non-original studies (e.g., editorials, case reports, opinion pieces). |
CRD420250632846 | How does risankizumab affect remission and safety in inflammatory bowel disease compared to placebo or other treatments, based on RCTs and real-world studies? | The systematic review focuses on inflammatory bowel disease (IBD), a chronic and relapsing group of disorders primarily comprising Crohn's disease (CD) and ulcerative colitis (UC). These conditions are characterized by persistent inflammation of the gastrointestinal tract, leading to symptoms such as abdominal pain, di... | null |
CRD42023440137 | What are the most appropriate, valid, and reliable instruments to assess the health-related quality of life in people with hereditary angioedema (HAE) (any type)?
1) Population: in people (any age) with hereditary angioedema (HAE) (any type)
2) type of Instruments: Any type of instrument (ie questionnaire, inventory) a... | The purpose of the review is to identify, analyse and summarise the critical aspects of all the tools present in the scientific literature that measure the health-related quality of life (HR-QoL) in people with hereditary angioedema (HAE).
The construct “health-related quality of life” is a subjective measurement that ... | null |
CRD420251025847 | Comparative efficacy of hypoglossal nerve stimulation | Study patients were diagnosed with OSAHS through PSG,according to American Academy of Sleep Medicine(AASM) stadards. Patients with OSAHS accepting the treatment of hypoglossal nerve stimulation PICO tags selected: Continuous Positive Airway Pressure Ventilation | Patients with other types of sleep disorders or concomitant cardiovascular and pulmonary diseases |
CRD420251037317 | Evaluate the efficacy of commonly used injectable drugs in treating tennis elbow in clinical practice | Adult patients who have undergone injection therapy for the treatment of lateral epicondylitis. Injection therapy, such as normal saline, hypertonic saline solution, hormones, botulinum toxin, platelet-rich plasma, non-steroidal anti-inflammatory drugs, local anesthetics, sodium hyaluronate solution. We will compare re... | null |
CRD42023479283 | This review examines suicidality in participants with treatment resistant depression in randomised clinical trials who have been given a therapeutic dose of psilocybin compared to a control group (active placebo, inactive placebo and waiting list control) | Major depressive disorder (MDD) is the condition that causes the largest burden of disability worldwide and is common with 1 in 6 UK adults reporting moderate to severe depression symptoms in 2022. Depression is costly on both an individual and societal level. Treatment resistance (or difficult to treat depression) is ... | null |
CRD420250648720 | "What are the reported clinical success rates and complication profiles of various therapeutic interventions for Cracked Tooth Syndrome as synthesized from systematic reviews and meta-analyses?" | Cracked Tooth; Therapeutic Procedure Cracked Tooth Syndrome (CTS) is a dental condition characterized by the presence of incomplete fractures within a tooth, often leading to discomfort and functional limitations. Unlike fully fractured teeth, cracks in CTS may not be immediately visible, making diagnosis challenging. ... | null |
CRD420251015040 | Review Objectives: | Population Inclusion Criteria: Patients diagnosed with: Advanced gastric adenocarcinoma Gastroesophageal junction (GEJ) adenocarcinoma Esophageal adenocarcinoma HER2-negative status Unresectable or metastatic disease Patients receiving first-line treatment Studies including adult patients (≥18 years old) Randomized con... | null |
CRD42022320515 | Whether could cancer patients with psychological stress benefit more from the acceptance and commitment therapy (ACT), which is considered as one of the third wave cognitive behavior therapy？ | Cancer. Cognitive behavior therapy. Psychotherapy. | null |
CRD420250551268 | What is Anti-inflammatory and Anti-Fibrotic Potential Factors for Liver Regeneration from Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes? | The implementation of the hUC-MSC-exo method into clinical trials itself should be done under cautious screening of the subject's condition to prevent any unwanted adverse events. Further specification of indications hUC-MSC-exo method may be beneficial, important, and highly suggested by the writers to be analyzed in ... | - Animal type: Studies using animals other than mice were excluded.- Model type: Ex vivo, in vitro, or in silico models were not considered.- Comorbidities: Studies involving animals with co-morbid conditions outside of liver diseases were excluded.- Inaccessible or incomplete studies: Studies that had irretrievable fu... |
CRD42021271805 | daptomycine efficacy and safety compared to standard of care (other Gram + antibacterial agents | Daptomycin is a lipoglycopeptide that is active against resistant Gram positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). Originally recommended for complicated gram positive bloodstream and skin and soft tissue infection (cSSTI), its indication has recently been extended to bone and joint ... | null |
CRD420251017432 | The purpose of this study is to conduct a comprehensive network meta-analysis to systematically evaluate the impact of various exercise interventions on executive function in children and adolescents with neurodevelopmental disorders. By synthesizing and comparing data from multiple randomized controlled trials, this r... | Children and adolescents with Neurodevelopmental Disorders Exercise Interventions Children and adolescents with Neurodevelopmental Disorders | null |
CRD420251017175 | null | Human Participants: Patients diagnosed with multiple sclerosis (MS) of any subtype, including relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), or other recognized variants, regardless of age, sex, disease duration, or severity. Preclinical Models: Animal models of MS, such ... | Non-MS Populations: Participants or models with neurological conditions unrelated to multiple sclerosis (e.g., Alzheimer's disease, Parkinson's disease, stroke), where MS is not the primary focus or data cannot be separated. No MSC Therapy: Populations not treated with mesenchymal stem cell (MSC) therapy, including tho... |
CRD42024587127 | What are the clinical and angiographic characteristics of craniocervical junction dural arteriovenous fistulas and associated clinical and angiographic outcomes of microsurgery, embolization, and conservative management? | craniocervical junction dural arteriovenous fistulas | null |
CRD42018095821 | What is the efficacy of praziquantel-associated immunomodulators in mice infected with Schistosoma mansoni when compared to control mice infected with S. mansoni and treated only with praziquantel? | Schistosomiasis mansoni is a parasitic disease, caused by Schistosoma mansoni, whose adult forms inhabit the mesenteric vessels of the definitive host and the intermediate forms develop in snail aquatic gastropods of the genus Biomphalaria. It is a disease, initially asymptomatic, that can progress to extremely severe ... | Studies with other animals as a model, in vitro studies and studies in humans will be excluded. Studies that did not use immunomodulators Studies that did not use a group of infected mice treated with praziquantel alone will be excluded. |
CRD42021251040 | does the addition of core-focused therapeutic exercises improve outcomes in patients with patellofemoral pain syndrome compared to standard interventions aimed exclusively at the hip and knee? | Patellofemoral pain syndrome | null |
CRD42025637689 | Population: Individuals with traumatic brain injury (TBI), head injury, or brain trauma.
Intervention: Music-based interventions, including music therapy, music intervention, auditory stimulation, and therapeutic music.
Comparator: No intervention or standard care.
Outcomes: Cognitive outcomes (e.g., cognitive function... | Traumatic brain injury (TBI) is a complex disorder where the brain is damaged by external factors. Depending on the severity and location of the injury, people may experience different levels of physical, cognitive, emotional, and behavioral difficulties. This systematic review examines how well music-based therapies c... | null |
CRD420251013483 | What is the age range of participants of patients with 6p CN LOH in aplastic anaemia? | Inclusion - A diagnosis of aplastic anaemia in patients of any age - A diagnosis of 6p Loss of Heterozygosity by any method Genetic testing Aplastic Anaemia without 6p Copy Number Loss of Heterozygosity All RCT, cohort, case series, and case reports. | Exclusion - Not having a diagnosis of aplastic anaemia Aplastic Anaemia without 6p Copy Number Loss of Heterozygosity |
CRD420251030478 | To assess the impact of Lactobacillus crispatus M247 on the viral clearance of HPV in infected patients compared to no use of Lactobacillus crispatus M247. The study aims to synthesize evidence to understand its efficacy. | Individuals diagnosed with HPV infection, regardless of age, sex, or risk factors. Studies on patients diagnosed with HPV infection (any subtype). Studies evaluating the use of Lactobacillus crispatus M247 as an intervention. Outcomes reporting viral clearance of HPV, including reduction in viral load. Publications in ... | Studies without clear data on intervention (e.g., no specification of Lactobacillus crispatus M247). Studies focused on animal or in vitro models. Editorials, letters, conference abstracts, and non-peer-reviewed literature. Observational Studies. Studies focused on animal or in vitro models. Editorials, letters, confer... |
CRD420250634986 | What is the effectiveness of sensory diets in managing panic symptoms in adolescents? | Background: Adolescents frequently experience anxiety and panic attacks, which are often triggered by academic and social pressures. Schools are a critical environment for addressing these issues, as they are central to adolescents' daily lives. Sensory-based activities that leverage sensory inputs (e.g., tactile, visu... | null |
CRD420250644885 | The influence of the nocebo effect, diagnosis threat and stereotype threat on memory: a systematic review. - What is the influence of the nocebo effect, diagnosis threat and stereotype threat on memory? This phenomenon has not been previously been reviewed. - It is recognised that another systematic review has briefly ... | Memory performance The review will be examining the influence of the nocebo effect, diagnosis threat and stereotype threat on memory. Broadly, the nocebo effect, diagnosis threat and stereotype threat refer to the production of an aversive response despite the absence of direct therapeutic effects (i.e. people expect n... | null |
CRD42021285791 | Does lingual arch reduces time of fixed orthodontic treatment in extraction and non-extraction cases of class I malocclusion with mandibular incisor crowding | Effectiveness of lingual arch appliance in fixed orthodontic treatment of Class I extraction and non-extraction cases with mandibular incisor crowding | null |
CRD42022361964 | This review is intended to evaluate the effectiveness and safety of acupuncture on cyclic mastalgia | A Systematic Review and Meta-Analysis of the Efficacy of Acupuncture on cyclic mastalgia
Approximately 60 to 70% of women have been plagued by mastalgia during their lifetime. According to menstrual cycle, mastalgia can be divided into two types: cyclic mastalgia (CM) and noncyclic mastalgia. CM is more likely to occur... | null |
CRD42023411073 | The aim of this meta-analysis of randomized controlled trials is to evaluate and compare the efficacy of extracorporeal shock wave, ultrasound, short wave diathermy and laser therapy in combination with exercise for the management of knee osteoarthritis. | Knee osteoarthritis is a common cause of musculoskeletal pain and a leading cause of disability and healthcare economic burden. Exercise programs and several physical modality treatments were developed aiming at a better symptomatic control of knee osteoarthritis and have demonstrated favorable results. However, it rem... | null |
CRD42022323696 | 1) To yield pooled area under the receiver-operator curves (AUCs) for nomograms developed to predict outcomes after 177Lu-PSMA in patients with mCRPC
2) To provide estimates of basic summative survival (OS, PFS, PSA decline)
3) To assess the influence of basic prognostic variables | Lutetium-177 (177Lu) prostate-specific membrane antigen (177Lu-PSMA) is a novel targeted treatment for patients with metastatic castration-resistant prostate cancer (mCRPC). Predictors of outcomes after 177Lu-PSMA were identified and nomograms develop. Validated nomograms that are predictive of outcomes after 177Lu-PSM... | null |
CRD42024522438 | P：Population for local staging of prostate cancer
I：68Ga-PSMA PET
C：mpMRI
O：sensitivity and specificity for extracapsular extension (ECE)
sensitivity and specificity for seminal vesicle invasion (SVI)
S：Retrospective research, Prospective research | Prostate cancer, one of the most prevalent malignancies in men, poses significant diagnostic and staging challenges. Accurate local staging is pivotal for guiding therapeutic decisions and predicting prognosis. The emergence of advanced imaging modalities has notably enhanced our diagnostic capabilities.
68Ga-PSMA PET,... | null |
CRD420250513190 | What methodological approaches to surface electromyography (sEMG) are reported in randomised controlled trials investigating musculoskeletal interventions. | Electromyography; Surface Emg; Exercise therapy; Physical Exercises; Functional Performance And Activity; Performance Feedback The use of sEMG in evaluating musculoskeletal exercise interventions. - Population (Healthy adults; aged 19-44yrs; ) - Study Design (has to have an exercise related physical intervention; has t... | - Population (paediatric and adolescents participants up to 18 years old, or aged 45 plus; generic and clinical health disorder involvement) - Study Design (related to nutrition, perception, imagery, biofeedback, latency or delay, muscle, specific aims for MSK performance depletion; non-exercise study intervention) - O... |
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