Datasets:

scbirlab
/

evo-pharm-atlas-1

target_taxon_id int64	target_taxon_l1 string	target_taxon_l2 string	target_taxon_l3 string	target_uniprot_id string	ortholog_uniprot_id string	target_accession string	ortholog_accession string	target_length int64	ortholog_length int64	alignment_length int64	target_ortholog_identity float64	gap_openings int64	mismatches int64	e_value float64	bit_score float64	target_ortholog_coverage float64	target_organism_name string	target_is_species_group int64	target_gene_symbol string	target_ec_number string	target_go_process_id string	target_go_process_name string	target_chembl_id string	target_name string	pLI float64	LOEUF float64	ortholog_target_name string	ortholog_target_locus string	ortholog_taxon_id int64	target_is_human bool	target_is_bacteria bool
83,333	Bacteria	Gram-Negative	Escherichia	P0A6A8	A0A2K9LV85	sp\|P0A6A8\|ACP_ECOLI	tr\|A0A2K9LV85\|A0A2K9LV85_SPISQ	78	74	54	0.278	2	35	0.00637	27.7	0.692308	Escherichia coli (strain K12)	0	acpP	null	GO:0044281;GO:0006629;GO:0009058	small molecule metabolic process; lipid metabolic process; biosynthetic process	CHEMBL3309006	Acyl carrier protein	null	null	acpP	SMONO_v1c07040	1,336,748	false	true
9,606	Eukaryotes	Mammalia	Primates	Q9H3K6	A0ABM5MV56	sp\|Q9H3K6\|BOLA2_HUMAN	tr\|A0ABM5MV56\|A0ABM5MV56_RICCA	86	83	77	0.286	2	52	0.00922	27.7	0.895349	Homo sapiens	0	BOLA2B	null	GO:0042592;GO:0022607;GO:0051604	protein maturation; cellular component assembly; homeostatic process	CHEMBL5724752	BolA-like protein 2	null	null	RCA_04810	RCA_04810	1,105,107	true	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	S5MIL8	sp\|P00845\|ATPL_BACP3	tr\|S5MIL8\|S5MIL8_9MOLU	72	110	45	0.311	0	31	0.00855	27.7	0.625	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	SDIMI_v3c00510	1,276,221	false	true
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A6I6C9C5	sp\|P00845\|ATPL_BACP3	tr\|A0A6I6C9C5\|A0A6I6C9C5_9MOLU	72	104	58	0.293	0	41	0.00749	28.1	0.805556	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	STABA_v1c01340	324,079	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0ABY8LVR9	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0ABY8LVR9\|A0ABY8LVR9_9BACT	81	94	68	0.338	2	42	0.00693	28.1	0.839506	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	QEG99_02110	171,286	false	true
9,606	Eukaryotes	Mammalia	Primates	P56385	P75078	sp\|P56385\|ATP5I_HUMAN	sp\|P75078\|Y036_MYCPN	69	673	26	0.615	0	10	0.0066	28.1	0.376812	Homo sapiens	0	ATP5ME	null	GO:0006810;GO:0044281;GO:0009058;GO:0055085	transport; biosynthetic process; small molecule metabolic process; transmembrane transport	CHEMBL6067089	ATP synthase F(0) complex subunit e, mitochondrial	0.000282	1.607	MPN_036	MPN_036	272,634	true	false
9,606	Eukaryotes	Mammalia	Primates	P09669	W5UUT3	sp\|P09669\|COX6C_HUMAN	tr\|W5UUT3\|W5UUT3_9BACT	75	164	38	0.368	1	23	0.00673	28.1	0.506667	Homo sapiens	0	COX6C	null	GO:0006091	generation of precursor metabolites and energy	CHEMBL6066369	Cytochrome c oxidase subunit 6C	0.31427	1.231	MYB_02930	MYB_02930	743,966	true	false
1,772	Bacteria	Gram-Positive	Mycobacterium	Q5TIX5	A0A501XC21	tr\|Q5TIX5\|Q5TIX5_MYCSM	tr\|A0A501XC21\|A0A501XC21_9BACT	86	96	52	0.346	1	32	0.00556	28.1	0.604651	Mycobacterium smegmatis	0	atpE	null	GO:0008152;GO:0009058;GO:0055085;GO:0006810	metabolic process; transmembrane transport; biosynthetic process; transport	CHEMBL1641346	Putative uncharacterized protein atpE	null	null	atpE	FJO69_00645	92,403	false	true
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0ABZ2RT75	sp\|P00845\|ATPL_BACP3	tr\|A0ABZ2RT75\|A0ABZ2RT75_9BACT	72	80	60	0.3	1	37	0.00347	28.1	0.833333	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	WG617_01490	35,768	false	true
83,333	Bacteria	Gram-Negative	Escherichia	P69346	A0A3X8R302	sp\|P69346\|YEFM_ECOLI	tr\|A0A3X8R302\|A0A3X8R302_CAMUP	83	71	52	0.327	1	34	0.01	28.1	0.626506	Escherichia coli (strain K12)	0	yefM	null	GO:0008150	biological_process	CHEMBL3309007	Antitoxin YefM	null	null	CT510_00875	CT510_00875	28,080	false	true
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A4P7AG08	sp\|P00845\|ATPL_BACP3	tr\|A0A4P7AG08\|A0A4P7AG08_9MOLU	72	103	58	0.293	0	41	0.00686	28.1	0.805556	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	SGLAD_v1c00630	2,143	false	true
5,661	Eukaryotes	Kinetoplastida	Leishmania	Q25270	A0AAE3EP81	tr\|Q25270\|Q25270_LEIDO	tr\|A0AAE3EP81\|A0AAE3EP81_9FLAO	43	102	23	0.435	0	13	0.00715	28.1	0.534884	Leishmania donovani	0	beta-tubulin	null	null	null	CHEMBL3186	Beta tubulin	null	null	L3X37_08905	L3X37_08905	2,044,858	false	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	C5ZV94	tr\|G3EFH9\|G3EFH9_PANVG	tr\|C5ZV94\|C5ZV94_9HELI	81	94	23	0.435	0	13	0.00828	28.5	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	fdxA	HCAN_0034	537,970	false	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	Q0PBH6	tr\|G3EFH9\|G3EFH9_PANVG	tr\|Q0PBH6\|Q0PBH6_CAMJE	81	94	23	0.435	0	13	0.00852	28.5	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	fdxA	Cj0333c	192,222	false	false
1,772	Bacteria	Gram-Positive	Mycobacterium	Q5TIX5	A0A7L7KRR7	tr\|Q5TIX5\|Q5TIX5_MYCSM	tr\|A0A7L7KRR7\|A0A7L7KRR7_9MOLU	86	82	27	0.444	0	15	0.00981	28.5	0.313953	Mycobacterium smegmatis	0	atpE	null	GO:0008152;GO:0009058;GO:0055085;GO:0006810	metabolic process; transmembrane transport; biosynthetic process; transport	CHEMBL1641346	Putative uncharacterized protein atpE	null	null	atpE	G4Z02_06525	2,782,163	false	true
9,544	Eukaryotes	Mammalia	Primates	Q8SPZ1	A0ABW4C307	sp\|Q8SPZ1\|GNRHR_MACMU	tr\|A0ABW4C307\|A0ABW4C307_9LACO	59	79	34	0.412	1	16	0.00597	28.5	0.576271	Macaca mulatta	0	GNRHR	null	GO:0007165	signal transduction	CHEMBL5647	Gonadotropin-releasing hormone receptor	null	null	ACFQ5L_11795	ACFQ5L_11795	2,559,920	false	false
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	C5ZV94	sp\|P10098\|PSAC_SPIOL	tr\|C5ZV94\|C5ZV94_9HELI	81	94	23	0.435	0	13	0.00828	28.5	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	fdxA	HCAN_0034	537,970	false	false
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0ABS7JN89	sp\|P10098\|PSAC_SPIOL	tr\|A0ABS7JN89\|A0ABS7JN89_9HELI	81	94	23	0.435	0	13	0.00903	28.5	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	K4G57_05155	K4G57_05155	2,867,412	false	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0ABS7JN89	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0ABS7JN89\|A0ABS7JN89_9HELI	81	94	23	0.435	0	13	0.00903	28.5	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	K4G57_05155	K4G57_05155	2,867,412	false	false
9,606	Eukaryotes	Mammalia	Primates	Q8WUW1	A0ABW5KAK6	sp\|Q8WUW1\|BRK1_HUMAN	tr\|A0ABW5KAK6\|A0ABW5KAK6_9FLAO	75	87	65	0.308	2	35	0.00935	28.5	0.866667	Homo sapiens	0	BRK1	null	GO:0009790;GO:0007010;GO:0048870;GO:0007165;GO:0008150;GO:0008283	cell proliferation; cytoskeleton organization; biological_process; cell motility; signal transduction; embryo development	CHEMBL3758062	Protein BRICK1	0.010906	1.766	ACFSO8_06820	ACFSO8_06820	1,849,733	true	false
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0ABS0ZIR7	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0ABS0ZIR7\|A0ABS0ZIR7_9STRE	81	66	36	0.389	1	21	0.00556	28.5	0.444444	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	JHK62_04410	JHK62_04410	2,740,577	false	true
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0ABX7LPM4	sp\|P00845\|ATPL_BACP3	tr\|A0ABX7LPM4\|A0ABX7LPM4_9CAUL	72	74	51	0.353	0	33	0.00982	28.5	0.708333	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	JX001_13825	2,813,778	false	true
9,544	Eukaryotes	Mammalia	Primates	Q8SPZ1	A0ABW1R5K0	sp\|Q8SPZ1\|GNRHR_MACMU	tr\|A0ABW1R5K0\|A0ABW1R5K0_9LACO	59	79	34	0.412	1	16	0.00623	28.5	0.576271	Macaca mulatta	0	GNRHR	null	GO:0007165	signal transduction	CHEMBL5647	Gonadotropin-releasing hormone receptor	null	null	ACFP3T_03260	ACFP3T_03260	2,559,919	false	false
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	D3SM38	sp\|P9WPS0\|ATPL_MYCTO	tr\|D3SM38\|D3SM38_THEAH	81	101	40	0.425	1	21	0.00868	28.5	0.493827	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	Thal_1186	638,303	false	true
83,333	Bacteria	Gram-Negative	Escherichia	P69346	A0ABT7I3E5	sp\|P69346\|YEFM_ECOLI	tr\|A0ABT7I3E5\|A0ABT7I3E5_9BACT	83	71	52	0.327	1	34	0.0066	28.5	0.626506	Escherichia coli (strain K12)	0	yefM	null	GO:0008150	biological_process	CHEMBL3309007	Antitoxin YefM	null	null	NYG95_03735	NYG95_03735	2,974,565	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0ABT7LSB7	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0ABT7LSB7\|A0ABT7LSB7_9STRE	81	66	48	0.333	0	32	0.00699	28.5	0.592593	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	QRD39_05310	3,053,355	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0A934P9T1	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0A934P9T1\|A0A934P9T1_9STRE	81	66	36	0.389	1	21	0.00535	28.5	0.444444	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	JHK64_02900	JHK64_02900	640,031	false	true
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0ABY3G6P5	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0ABY3G6P5\|A0ABY3G6P5_9BACT	81	94	23	0.435	0	13	0.00805	28.5	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	XK09_06595	XK09_06595	75,658	false	false
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0ABY3G6P5	sp\|P10098\|PSAC_SPIOL	tr\|A0ABY3G6P5\|A0ABY3G6P5_9BACT	81	94	23	0.435	0	13	0.00805	28.5	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	XK09_06595	XK09_06595	75,658	false	false
224,308	Bacteria	Gram-Positive	Bacillus	P96618	N9VD45	sp\|P96618\|ACPS_BACSU	tr\|N9VD45\|N9VD45_9BACT	121	102	93	0.301	4	54	0.00947	28.5	0.768595	Bacillus subtilis (strain 168)	0	acpS	2.7.8.7	GO:0006520;GO:0044281;GO:0006629;GO:0009058	biosynthetic process; cellular amino acid metabolic process; lipid metabolic process; small molecule metabolic process	CHEMBL4734	Holo-[acyl-carrier-protein] synthase	null	null	acpS	MAU_0430	51,363	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	Q5M5J7	sp\|P9WPS0\|ATPL_MYCTO	tr\|Q5M5J7\|Q5M5J7_STRT2	81	65	48	0.333	0	32	0.00506	28.5	0.592593	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	stu0478	264,199	false	true
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	Q0PBH6	sp\|P10098\|PSAC_SPIOL	tr\|Q0PBH6\|Q0PBH6_CAMJE	81	94	23	0.435	0	13	0.00852	28.5	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	fdxA	Cj0333c	192,222	false	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0AAW6HS22	sp\|P00845\|ATPL_BACP3	tr\|A0AAW6HS22\|A0AAW6HS22_9MOLU	72	95	53	0.321	0	36	0.00382	28.5	0.736111	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	LNO68_01975	2,963,128	false	true
224,308	Bacteria	Gram-Positive	Bacillus	P96618	N9VD45	sp\|P96618\|ACPS_BACSU	tr\|N9VD45\|N9VD45_9BACT	121	102	93	0.301	4	54	0.00947	28.5	0.768595	Bacillus subtilis (strain 168)	0	acpS	2.7.8.7	GO:0006520;GO:0044281;GO:0006629;GO:0009058	biosynthetic process; cellular amino acid metabolic process; lipid metabolic process; small molecule metabolic process	CHEMBL4734	Holo-[acyl-carrier-protein] synthase	null	null	acpS	MAU_0430	1,188,233	false	true
9,606	Eukaryotes	Mammalia	Primates	P10145	A0ABP0T3R3	sp\|P10145\|IL8_HUMAN	tr\|A0ABP0T3R3\|A0ABP0T3R3_RICHE	99	77	57	0.298	1	31	0.00761	28.5	0.575758	Homo sapiens	0	CXCL8	null	GO:0002376;GO:0016192;GO:0048646;GO:0006950;GO:0048870;GO:0040011;GO:0006810;GO:0008150;GO:0007165;GO:0048856	cell motility; locomotion; biological_process; anatomical structure formation involved in morphogenesis; immune system process; transport; anatomical structure development; vesicle-mediated transport; signal transduction; response to stress	CHEMBL2157	Interleukin-8	0.003507	1.822	OB144RH_02815	OB144RH_02815	35,789	true	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A4Y9RY53	sp\|P00845\|ATPL_BACP3	tr\|A0A4Y9RY53\|A0A4Y9RY53_9CAUL	72	74	51	0.353	0	33	0.007	28.9	0.708333	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	EGY25_11420	74,315	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0ABS2PLJ9	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0ABS2PLJ9\|A0ABS2PLJ9_9STRE	81	69	48	0.333	0	32	0.00501	28.9	0.592593	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	JOC31_000966	1,349,416	false	true
9,615	Eukaryotes	Mammalia	Carnivora	Q4ZHP8	A0A848QN45	tr\|Q4ZHP8\|Q4ZHP8_CANLF	tr\|A0A848QN45\|A0A848QN45_9SPHN	61	328	33	0.424	0	19	0.00886	28.9	0.540984	Canis lupus familiaris	0	ADRA2A	null	null	null	CHEMBL5303559	Alpha-2A adrenergic receptor	null	null	HKD42_10975	HKD42_10975	2,730,337	false	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0ABV1J2J9	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0ABV1J2J9\|A0ABV1J2J9_9FIRM	81	72	20	0.55	0	9	0.00513	28.9	0.246914	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	AAA073_06025	AAA073_06025	1,465,757	false	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A3M0C5W9	sp\|P00845\|ATPL_BACP3	tr\|A0A3M0C5W9\|A0A3M0C5W9_9PROT	72	75	53	0.34	0	35	0.00918	28.9	0.736111	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	BXY39_2892	911,205	false	true
9,031	Eukaryotes	Aves	null	Q8QGU2	A0ABZ2AIM0	tr\|Q8QGU2\|Q8QGU2_CHICK	tr\|A0ABZ2AIM0\|A0ABZ2AIM0_9BACT	108	465	59	0.322	2	37	0.00944	28.9	0.546296	Gallus gallus	0	FKBP12.6	5.2.1.8	GO:0055085;GO:0050877;GO:0048856;GO:0032880;GO:0042592;GO:0002376;GO:0007165;GO:0008150;GO:0006810;GO:0006950;GO:0008283;GO:0009790	neurological system process; homeostatic process; biological_process; response to stress; regulation of protein localization; anatomical structure development; transport; signal transduction; immune system process; cell proliferation; transmembrane transport; embryo development	CHEMBL2301	FK506 binding protein 12	null	null	tig	V2E26_01365	35,769	false	false
11,676	Viruses	retro-transcribing	null	Q77YF9	C6XD03	tr\|Q77YF9\|Q77YF9_HV1	tr\|C6XD03\|C6XD03_METGS	78	74	39	0.385	2	17	0.00785	28.9	0.5	Human immunodeficiency virus 1	0	vpr	null	GO:0055085;GO:0006810;GO:0065003;GO:0044403;GO:0008150	transmembrane transport; biological_process; macromolecular complex assembly; symbiosis, encompassing mutualism through parasitism; transport	CHEMBL2146310	Aberrant vpr protein	null	null	Msip34_1181	Msip34_1181	582,744	false	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0ABT2ZAJ2	sp\|P00845\|ATPL_BACP3	tr\|A0ABT2ZAJ2\|A0ABT2ZAJ2_9RHOB	72	79	57	0.351	2	31	0.00879	28.9	0.791667	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	OEW28_04075	2,984,159	false	true
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0ABV1J2J9	sp\|P10098\|PSAC_SPIOL	tr\|A0ABV1J2J9\|A0ABV1J2J9_9FIRM	81	72	20	0.55	0	9	0.00513	28.9	0.246914	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	AAA073_06025	AAA073_06025	1,465,757	false	false
9,606	Eukaryotes	Mammalia	Primates	Q96IX5	A0ABT5GB99	sp\|Q96IX5\|ATPMK_HUMAN	tr\|A0ABT5GB99\|A0ABT5GB99_9MOLU	58	975	42	0.381	1	25	0.00278	28.9	0.724138	Homo sapiens	0	ATP5MK	null	GO:0009058;GO:0044281	biosynthetic process; small molecule metabolic process	CHEMBL6066304	ATP synthase F(0) complex subunit k, mitochondrial	0.004163	1.615	LNO68_02950	LNO68_02950	2,963,128	true	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0A076F8U1	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0A076F8U1\|A0A076F8U1_9BACT	81	94	23	0.435	0	13	0.00643	28.9	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	fdxA	CIG1485E_0247	1,244,531	false	false
9,606	Eukaryotes	Mammalia	Primates	P62273	A0A1K1QGC1	sp\|P62273\|RS29_HUMAN	tr\|A0A1K1QGC1\|A0A1K1QGC1_SELRU	56	61	41	0.341	2	24	0.00277	28.9	0.732143	Homo sapiens	0	RPS29	null	GO:0006412	translation	CHEMBL6066849	Small ribosomal subunit protein uS14	0.98356	0.308	rpsZ	E7203_11160	971	true	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A5C5GHL5	sp\|P00845\|ATPL_BACP3	tr\|A0A5C5GHL5\|A0A5C5GHL5_9RHOB	72	78	56	0.375	1	31	0.00933	28.9	0.777778	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	FHY64_09140	2,588,711	false	true
9,606	Eukaryotes	Mammalia	Primates	P42766	A0A179C228	sp\|P42766\|RL35_HUMAN	tr\|A0A179C228\|A0A179C228_9LACO	123	64	62	0.306	1	42	0.00843	28.9	0.504065	Homo sapiens	0	RPL35	null	GO:0006412;GO:0008152	translation; metabolic process	CHEMBL6066900	Large ribosomal subunit protein uL29	0.99218	0.391	rpmC	A3O14_03650	1,606	true	false
83,333	Bacteria	Gram-Negative	Escherichia	P69346	D2Z6P1	sp\|P69346\|YEFM_ECOLI	tr\|D2Z6P1\|D2Z6P1_9BACT	83	92	25	0.52	0	12	0.0097	28.9	0.301205	Escherichia coli (strain K12)	0	yefM	null	GO:0008150	biological_process	CHEMBL3309007	Antitoxin YefM	null	null	Dpep_1112	Dpep_1112	469,381	false	true
9,986	Eukaryotes	Mammalia	Lagomorpha	P81123	Q5M2C8	sp\|P81123\|KC1D_RABIT	sp\|Q5M2C8\|RL6_STRT2	81	178	71	0.282	1	49	0.00871	28.9	0.876543	Oryctolagus cuniculus	0	CSNK1D	2.7.11.26	GO:0008150;GO:0016310;GO:0007165	phosphorylation; signal transduction; biological_process	CHEMBL3309063	Casein kinase I isoform delta	null	null	rplF	stu1919	264,199	false	false
11,676	Viruses	retro-transcribing	null	Q77YF9	Q99YL3	tr\|Q77YF9\|Q77YF9_HV1	sp\|Q99YL3\|Y1647_STRP1	78	171	59	0.305	2	32	0.00885	28.9	0.75641	Human immunodeficiency virus 1	0	vpr	null	GO:0055085;GO:0006810;GO:0065003;GO:0044403;GO:0008150	transmembrane transport; biological_process; macromolecular complex assembly; symbiosis, encompassing mutualism through parasitism; transport	CHEMBL2146310	Aberrant vpr protein	null	null	SPy_1647	SPy_1647	301,447	false	false
224,308	Bacteria	Gram-Positive	Bacillus	P96618	A0A6M4JBI9	sp\|P96618\|ACPS_BACSU	tr\|A0A6M4JBI9\|A0A6M4JBI9_9MOLU	121	104	83	0.325	4	46	0.0075	28.9	0.68595	Bacillus subtilis (strain 168)	0	acpS	2.7.8.7	GO:0006520;GO:0044281;GO:0006629;GO:0009058	biosynthetic process; cellular amino acid metabolic process; lipid metabolic process; small molecule metabolic process	CHEMBL4734	Holo-[acyl-carrier-protein] synthase	null	null	HLA87_01505	HLA87_01505	754,515	false	true
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0ABT2ZMJ1	sp\|P00845\|ATPL_BACP3	tr\|A0ABT2ZMJ1\|A0ABT2ZMJ1_9RHOB	72	79	57	0.351	2	31	0.00926	28.9	0.791667	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	OEZ71_08505	2,984,134	false	true
9,606	Eukaryotes	Mammalia	Primates	Q9NZ42	S5M048	sp\|Q9NZ42\|PEN2_HUMAN	tr\|S5M048\|S5M048_9MOLU	101	143	60	0.317	2	20	0.00839	28.9	0.594059	Homo sapiens	0	PSENEN	null	GO:0006508;GO:0016485;GO:0043085;GO:0007165;GO:0008152;GO:0008150	protein processing; metabolic process; positive regulation of catalytic activity; biological_process; signal transduction; proteolysis	CHEMBL2374	Gamma-secretase subunit PEN-2	0.9327	0.552	SDIMI_v3c05070	SDIMI_v3c05070	1,276,221	true	false
562	Bacteria	Gram-Negative	Escherichia	P69913	A0ABW3PBC4	sp\|P69913\|CSRA_ECOLI	tr\|A0ABW3PBC4\|A0ABW3PBC4_9LACO	61	171	37	0.378	1	22	0.00838	28.9	0.606557	Escherichia coli	0	csrA	null	GO:0034655;GO:0008150	nucleobase-containing compound catabolic process; biological_process	CHEMBL5169227	Carbon storage regulator	null	null	ACFQ22_00345	ACFQ22_00345	1,987,503	false	true
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0A3S4WKP2	sp\|P10098\|PSAC_SPIOL	tr\|A0A3S4WKP2\|A0A3S4WKP2_CAMUP	81	94	23	0.435	0	13	0.00667	28.9	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	fdxA_2	CT510_07110	28,080	false	false
1,772	Bacteria	Gram-Positive	Mycobacterium	Q5TIX5	Q59550	tr\|Q5TIX5\|Q5TIX5_MYCSM	sp\|Q59550\|ATPL_MYCPN	86	105	53	0.302	1	35	0.00371	28.9	0.616279	Mycobacterium smegmatis	0	atpE	null	GO:0008152;GO:0009058;GO:0055085;GO:0006810	metabolic process; transmembrane transport; biosynthetic process; transport	CHEMBL1641346	Putative uncharacterized protein atpE	null	null	atpE	MPN_603	272,634	false	true
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0A076F8U1	sp\|P10098\|PSAC_SPIOL	tr\|A0A076F8U1\|A0A076F8U1_9BACT	81	94	23	0.435	0	13	0.00643	28.9	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	fdxA	CIG1485E_0247	1,244,531	false	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0A2G4R147	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0A2G4R147\|A0A2G4R147_9BACT	81	94	23	0.435	0	13	0.00607	28.9	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	AA994_05590	AA994_05590	1,655,500	false	false
9,606	Eukaryotes	Mammalia	Primates	P42766	Q5F5T5	sp\|P42766\|RL35_HUMAN	sp\|Q5F5T5\|RL29_NEIG1	123	63	60	0.367	1	37	0.00996	28.9	0.487805	Homo sapiens	0	RPL35	null	GO:0006412;GO:0008152	translation; metabolic process	CHEMBL6066900	Large ribosomal subunit protein uL29	0.99218	0.391	rpmC	NGO_1831	242,231	true	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A2S8S809	sp\|P00845\|ATPL_BACP3	tr\|A0A2S8S809\|A0A2S8S809_9RHOB	72	79	57	0.351	2	31	0.00953	28.9	0.791667	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	LX70_01811	404,881	false	true
224,308	Bacteria	Gram-Positive	Bacillus	P96618	B3PLS3	sp\|P96618\|ACPS_BACSU	tr\|B3PLS3\|B3PLS3_META1	121	98	39	0.436	1	18	0.00705	28.9	0.322314	Bacillus subtilis (strain 168)	0	acpS	2.7.8.7	GO:0006520;GO:0044281;GO:0006629;GO:0009058	biosynthetic process; cellular amino acid metabolic process; lipid metabolic process; small molecule metabolic process	CHEMBL4734	Holo-[acyl-carrier-protein] synthase	null	null	acpS	MARTH_orf008	243,272	false	true
9,606	Eukaryotes	Mammalia	Primates	Q8WUW1	A0A1J0KW86	sp\|Q8WUW1\|BRK1_HUMAN	tr\|A0A1J0KW86\|A0A1J0KW86_9GAMM	75	350	63	0.317	1	36	0.00994	28.9	0.84	Homo sapiens	0	BRK1	null	GO:0009790;GO:0007010;GO:0048870;GO:0007165;GO:0008150;GO:0008283	cell proliferation; cytoskeleton organization; biological_process; cell motility; signal transduction; embryo development	CHEMBL3758062	Protein BRICK1	0.010906	1.766	KX01_908	KX01_908	1,542,390	true	false
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0ABT7I1Q8	sp\|P10098\|PSAC_SPIOL	tr\|A0ABT7I1Q8\|A0ABT7I1Q8_9BACT	81	94	23	0.435	0	13	0.00618	28.9	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	NYG95_00855	NYG95_00855	2,974,565	false	false
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0ABP2NQQ7	sp\|P10098\|PSAC_SPIOL	tr\|A0ABP2NQQ7\|A0ABP2NQQ7_CAMCO	81	94	23	0.435	0	13	0.00713	28.9	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	cco14_06625	cco14_06625	887,288	false	false
1,772	Bacteria	Gram-Positive	Mycobacterium	Q5TIX5	D3SM38	tr\|Q5TIX5\|Q5TIX5_MYCSM	tr\|D3SM38\|D3SM38_THEAH	86	101	40	0.45	1	20	0.00712	28.9	0.465116	Mycobacterium smegmatis	0	atpE	null	GO:0008152;GO:0009058;GO:0055085;GO:0006810	metabolic process; transmembrane transport; biosynthetic process; transport	CHEMBL1641346	Putative uncharacterized protein atpE	null	null	atpE	Thal_1186	638,303	false	true
9,606	Eukaryotes	Mammalia	Primates	P42766	A0A3D8J7I7	sp\|P42766\|RL35_HUMAN	tr\|A0A3D8J7I7\|A0A3D8J7I7_9HELI	123	65	66	0.409	2	36	0.00922	28.9	0.536585	Homo sapiens	0	RPL35	null	GO:0006412;GO:0008152	translation; metabolic process	CHEMBL6066900	Large ribosomal subunit protein uL29	0.99218	0.391	rpmC	CQA57_05575	375,926	true	false
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0ABY5TYG0	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0ABY5TYG0\|A0ABY5TYG0_9BACT	81	93	68	0.338	2	42	0.0031	28.9	0.839506	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	NX772_01925	171,288	false	true
9,544	Eukaryotes	Mammalia	Primates	Q8SPZ1	A0ABW1RXL0	sp\|Q8SPZ1\|GNRHR_MACMU	tr\|A0ABW1RXL0\|A0ABW1RXL0_9LACO	59	79	33	0.424	1	15	0.00439	28.9	0.559322	Macaca mulatta	0	GNRHR	null	GO:0007165	signal transduction	CHEMBL5647	Gonadotropin-releasing hormone receptor	null	null	ACFP5Y_03130	ACFP5Y_03130	2,559,918	false	false
1,773	Bacteria	Gram-Positive	Mycobacterium	P9WIC1	E8KBS2	sp\|P9WIC1\|CHMU_MYCTU	tr\|E8KBS2\|E8KBS2_9STRE	105	88	53	0.264	0	39	0.00952	28.9	0.504762	Mycobacterium tuberculosis	0	null	5.4.99.5	GO:0006520;GO:0008152;GO:0009058;GO:0044281	cellular amino acid metabolic process; metabolic process; biosynthetic process; small molecule metabolic process	CHEMBL2069157	Intracellular chorismate mutase	null	null	HMPREF9180_0927	HMPREF9180_0927	888,746	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0A060RLR6	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0A060RLR6\|A0A060RLR6_9STRE	81	67	48	0.313	0	33	0.0057	28.9	0.592593	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	BN963_SGAL_02335	315,405	false	true
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0AAX2UIW7	sp\|P10098\|PSAC_SPIOL	tr\|A0AAX2UIW7\|A0AAX2UIW7_9BACT	81	94	23	0.435	0	13	0.00676	28.9	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	FDW42_07960	FDW42_07960	28,898	false	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0ABY4SHD4	sp\|P00845\|ATPL_BACP3	tr\|A0ABY4SHD4\|A0ABY4SHD4_9CAUL	72	74	51	0.353	0	33	0.007	28.9	0.708333	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	M8231_10045	1,312,364	false	true
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0A2G4R147	sp\|P10098\|PSAC_SPIOL	tr\|A0A2G4R147\|A0A2G4R147_9BACT	81	94	23	0.435	0	13	0.00607	28.9	0.283951	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	AA994_05590	AA994_05590	1,655,500	false	false
83,333	Bacteria	Gram-Negative	Escherichia	P69346	A0A4Z0Y1L5	sp\|P69346\|YEFM_ECOLI	tr\|A0A4Z0Y1L5\|A0A4Z0Y1L5_9FIRM	83	90	79	0.304	3	46	0.00909	28.9	0.951807	Escherichia coli (strain K12)	0	yefM	null	GO:0008150	biological_process	CHEMBL3309007	Antitoxin YefM	null	null	CAGA_12600	CAGA_12600	642,589	false	true
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0ABP2NQQ7	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0ABP2NQQ7\|A0ABP2NQQ7_CAMCO	81	94	23	0.435	0	13	0.00713	28.9	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	cco14_06625	cco14_06625	887,288	false	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0ABT7I1Q8	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0ABT7I1Q8\|A0ABT7I1Q8_9BACT	81	94	23	0.435	0	13	0.00618	28.9	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	NYG95_00855	NYG95_00855	2,974,565	false	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A318HSG3	sp\|P00845\|ATPL_BACP3	tr\|A0A318HSG3\|A0A318HSG3_9BACT	72	80	55	0.345	1	25	0.00737	28.9	0.763889	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	EJ73_01715	1,122,991	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0A1I1Z945	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0A1I1Z945\|A0A1I1Z945_9BACT	81	69	40	0.35	0	26	0.0091	28.9	0.493827	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	SAMN05444380_10938	385,682	false	true
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0AAX2UIW7	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0AAX2UIW7\|A0AAX2UIW7_9BACT	81	94	23	0.435	0	13	0.00676	28.9	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	FDW42_07960	FDW42_07960	28,898	false	false
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	I4ZBD2	sp\|P9WPS0\|ATPL_MYCTO	tr\|I4ZBD2\|I4ZBD2_9BACT	81	80	68	0.368	2	37	0.00706	28.9	0.839506	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	PrebiDRAFT_1844	868,129	false	true
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0A3S4WKP2	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0A3S4WKP2\|A0A3S4WKP2_CAMUP	81	94	23	0.435	0	13	0.00667	28.9	0.283951	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	fdxA_2	CT510_07110	28,080	false	false
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	E0PCR5	sp\|P9WPS0\|ATPL_MYCTO	tr\|E0PCR5\|E0PCR5_STREI	81	67	48	0.313	0	33	0.00486	28.9	0.592593	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	HMPREF9319_0638	864,569	false	true
9,606	Eukaryotes	Mammalia	Primates	P62273	A0A4Z0JFC7	sp\|P62273\|RS29_HUMAN	tr\|A0A4Z0JFC7\|A0A4Z0JFC7_9LACO	56	98	41	0.317	0	28	0.00418	28.9	0.732143	Homo sapiens	0	RPS29	null	GO:0006412	translation	CHEMBL6066849	Small ribosomal subunit protein uS14	0.98356	0.308	EGT49_11000	EGT49_11000	2,487,723	true	false
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	E0NL21	sp\|P10098\|PSAC_SPIOL	tr\|E0NL21\|E0NL21_9FIRM	81	72	38	0.447	1	20	0.00547	28.9	0.469136	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	HMPREF9225_0860	HMPREF9225_0860	862,517	false	false
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	E0NL21	tr\|G3EFH9\|G3EFH9_PANVG	tr\|E0NL21\|E0NL21_9FIRM	81	72	38	0.447	1	20	0.00547	28.9	0.469136	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	HMPREF9225_0860	HMPREF9225_0860	862,517	false	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0ABT2YYT4	sp\|P00845\|ATPL_BACP3	tr\|A0ABT2YYT4\|A0ABT2YYT4_9RHOB	72	79	57	0.351	2	31	0.00941	28.9	0.791667	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	OE647_04700	2,984,331	false	true
38,727	Eukaryotes	Viridiplantae	Other	G3EFH9	A0A6N3AQW8	tr\|G3EFH9\|G3EFH9_PANVG	tr\|A0A6N3AQW8\|A0A6N3AQW8_9FIRM	81	72	20	0.55	0	9	0.00498	28.9	0.246914	Panicum virgatum	0	psaC	1.97.1.12	GO:0006091;GO:0015979	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366434	Photosystem I iron-sulfur center	null	null	psaC	JOD41_001516	411,567	false	false
9,606	Eukaryotes	Mammalia	Primates	P42766	A0A0R1ZFT2	sp\|P42766\|RL35_HUMAN	tr\|A0A0R1ZFT2\|A0A0R1ZFT2_9LACO	123	64	62	0.306	1	42	0.00763	28.9	0.504065	Homo sapiens	0	RPL35	null	GO:0006412;GO:0008152	translation; metabolic process	CHEMBL6066900	Large ribosomal subunit protein uL29	0.99218	0.391	rpmC	FC64_GL000019	1,423,820	true	false
3,562	Eukaryotes	Viridiplantae	Eudicotyledons	P10098	A0A6N3AQW8	sp\|P10098\|PSAC_SPIOL	tr\|A0A6N3AQW8\|A0A6N3AQW8_9FIRM	81	72	20	0.55	0	9	0.00498	28.9	0.246914	Spinacia oleracea	0	psaC	1.97.1.12	GO:0015979;GO:0006091	photosynthesis; generation of precursor metabolites and energy	CHEMBL2366465	Photosystem I iron-sulfur center	null	null	psaC	JOD41_001516	411,567	false	false
9,606	Eukaryotes	Mammalia	Primates	P62857	A0A386PP43	sp\|P62857\|RS28_HUMAN	tr\|A0A386PP43\|A0A386PP43_9SPIR	69	901	55	0.291	2	32	0.00407	29.3	0.797101	Homo sapiens	0	RPS28	null	GO:0008152;GO:0006412;GO:0042254;GO:0022618	metabolic process; ribosome biogenesis; ribonucleoprotein complex assembly; translation	CHEMBL6067567	Small ribosomal subunit protein eS28	0.72076	0.908	DB313_03830	DB313_03830	1,104,446	true	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	A0A841MUF7	sp\|P00845\|ATPL_BACP3	tr\|A0A841MUF7\|A0A841MUF7_9BACT	72	85	63	0.349	1	30	0.00962	29.3	0.875	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	FHS59_001763	1,836,499	false	true
9,606	Eukaryotes	Mammalia	Primates	P42766	A0ABW4NMZ7	sp\|P42766\|RL35_HUMAN	tr\|A0ABW4NMZ7\|A0ABW4NMZ7_9LACT	123	64	62	0.339	1	40	0.00908	29.3	0.504065	Homo sapiens	0	RPL35	null	GO:0006412;GO:0008152	translation; metabolic process	CHEMBL6066900	Large ribosomal subunit protein uL29	0.99218	0.391	rpmC	ACFSBK_04500	2,126,436	true	false
2,334	Bacteria	Gram-Positive	Bacillus	P00845	S5LSV7	sp\|P00845\|ATPL_BACP3	tr\|S5LSV7\|S5LSV7_9MOLU	72	110	55	0.345	1	35	0.00231	29.3	0.763889	Bacillus sp.	1	atpE	null	GO:0008152;GO:0055085;GO:0006810;GO:0009058	transport; metabolic process; transmembrane transport; biosynthetic process	CHEMBL3308989	ATP synthase subunit c	null	null	atpE	STAIW_v1c00540	1,276,220	false	true
83,331	Bacteria	Gram-Positive	Mycobacterium	P9WPS0	A0A840K8S9	sp\|P9WPS0\|ATPL_MYCTO	tr\|A0A840K8S9\|A0A840K8S9_9FLAO	81	72	46	0.37	0	29	0.00719	29.3	0.567901	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	0	atpE	null	GO:0055085;GO:0009058;GO:0008152;GO:0006810	transmembrane transport; transport; biosynthetic process; metabolic process	CHEMBL4105701	ATP synthase subunit c	null	null	atpE	HNP38_000898	160,396	false	true
9,606	Eukaryotes	Mammalia	Primates	P42766	A0A5P3MQV9	sp\|P42766\|RL35_HUMAN	tr\|A0A5P3MQV9\|A0A5P3MQV9_NEIAN	123	63	60	0.367	1	37	0.00745	29.3	0.487805	Homo sapiens	0	RPL35	null	GO:0006412;GO:0008152	translation; metabolic process	CHEMBL6066900	Large ribosomal subunit protein uL29	0.99218	0.391	rpmC	D0T90_05270	492	true	false
83,333	Bacteria	Gram-Negative	Escherichia	P64602	A0ABV1CF15	sp\|P64602\|MLAB_ECOLI	tr\|A0ABV1CF15\|A0ABV1CF15_9FIRM	97	103	50	0.28	1	33	0.00845	29.3	0.515464	Escherichia coli (strain K12)	0	mlaB	null	GO:0061024;GO:0006810;GO:0046677;GO:0006950;GO:0008150	response to antibiotic; biological_process; transport; response to stress; membrane organization	CHEMBL3309025	Intermembrane phospholipid transport system binding protein MlaB	null	null	WMO19_07330	WMO19_07330	3,133,174	false	true
83,333	Bacteria	Gram-Negative	Escherichia	P0A7M2	A0A317ZGR9	sp\|P0A7M2\|RL28_ECOLI	tr\|A0A317ZGR9\|A0A317ZGR9_9BACT	78	76	46	0.348	1	17	0.00653	29.3	0.589744	Escherichia coli (strain K12)	0	rpmB	null	GO:0022618;GO:0006412	ribonucleoprotein complex assembly; translation	CHEMBL2363119	Large ribosomal subunit protein bL28	null	null	rpmB	DDZ13_05650	2,174,842	false	true
10,090	Eukaryotes	Mammalia	Rodentia	P35173	A0ABY5TUE3	sp\|P35173\|CYT3_MOUSE	tr\|A0ABY5TUE3\|A0ABY5TUE3_9BACT	103	687	83	0.229	2	54	0.00809	29.3	0.805825	Mus musculus	0	Stfa3	null	null	null	CHEMBL5291583	Stefin-3	null	null	rnr	NX772_00360	171,288	false	false

End of preview. Expand in Data Studio

evo-pharm-atlas-1

Calculated protein drug target conservation for 10,584 targets from ChEMBL v36 across 8207 bacterial proteomes from UniProt KB.

Dataset Details

Dataset Sources

Paper https://doi.org/10.1038/s41589-023-01349-8

Dataset Structure

The data are separated into four configs.

conservation

Conservation of canonical targets across bacterial proteomes.

target_taxon_id: NCBI taxonomy ID of source species of canonical drug target
target_taxon_l1: Approximately taxonomic Kingdom of canonical drug target (from ChEMBL)
target_taxon_l2: Approximately taxonomic Class of canonical drug target (from ChEMBL)
target_taxon_l3: Approximately taxonomic Family of canonical drug target (from ChEMBL)
target_uniprot_id: UniProt KB ID of canonical drug target protein
ortholog_uniprot_id: UniProt KB ID of ortholog protein
target_accession: Full UniProt accession ID of canonical drug target protein
ortholog_accession: Full UniProt accession ID of ortholog protein
target_length: Number of amino acids in canonical drug target
ortholog_length: Number of amino acids in ortholog protein
alignment_length: Length of BLASTp alignment (from Diamond)
target_ortholog_identity: Amino acid identity between drug target and ortholog (from Diamond)
gap_openings: Number of gaps in alignment (from Diamond)
mismatches: Number of mismatches in alignment (from Diamond)
e_value: Expectation-value of alignment (from Diamond)
bit_score: Score of alignment (from Diamond)
target_ortholog_coverage: Aligment length divided by query length
target_organism_name: Source species name of canonical drug target (from ChEMBL)
target_is_species_group: Flag whether target is annotated as being from a group of species, e.g. "Bacteria" (from ChEMBL)
target_gene_symbol: Gene symbol of canonical drug target (from ChEMBL)
target_ec_number: Enzyme Commission number drug target (from ChEMBL)
target_go_process_id: Semi-colon-separated list of Gene Ontology process IDs of canonical drug target (from ChEMBL)
target_go_process_name: Semi-colon-separated list of Gene Ontology process names of canonical drug target (from ChEMBL)
target_chembl_id: Canonical drug target ChEMBL ID
target_name: Canonical drug target name
pLI: For human targets, Probability of Loss-of-function Intolerance (from gNomad)
LOEUF: For human targets, Loss-of-function Observed/Expected Upper bound Fraction (from gNomad)
ortholog_target_name: Ortholog protein name
ortholog_target_locus: Ortholog gene locus tag
ortholog_taxon_id: NCBI taxonomy ID of source species of ortholog protein
target_is_human: Flag whether canonical drug target is human protein
target_is_bacteria: Flag whether canonical drug target is bacterial protein

canonical-target-info

Information on canonical drug targets and their aggregate conservation across bacterial proteomes.

target_uniprot_id: UniProt KB ID of canonical drug target protein
target_taxon_id: NCBI taxonomy ID of source species of canonical drug target
target_taxon_l1: Approximately taxonomic Kingdom of canonical drug target (from ChEMBL)
target_taxon_l2: Approximately taxonomic Class of canonical drug target (from ChEMBL)
target_taxon_l3: Approximately taxonomic Family of canonical drug target (from ChEMBL)
target_accession: Full UniProt accession ID of canonical drug target protein
target_length: Number of amino acids in canonical drug target
target_organism_name: Source species name of canonical drug target (from ChEMBL)
target_is_species_group: Flag whether target is annotated as being from a group of species, e.g. "Bacteria" (from ChEMBL)
target_gene_symbol: Gene symbol of canonical drug target (from ChEMBL)
target_ec_number: Enzyme Commission number drug target (from ChEMBL)
target_go_process_id: Semi-colon-separated list of Gene Ontology process IDs of canonical drug target (from ChEMBL)
target_go_process_name: Semi-colon-separated list of Gene Ontology process names of canonical drug target (from ChEMBL)
target_chembl_id: Canonical drug target ChEMBL ID
target_name: Canonical drug target name
target_is_human: Flag whether canonical drug target is human protein
target_is_bacteria: Flag whether canonical drug target is bacterial protein
entropy: Shannon entropy of target amino acid identity across all bacterial strains
sparsity: Sparsity index of target amino acid identity across all bacterial strains
mean_conservation: Mean target amino acid identity across all bacterial strains
median_conservation: Median target amino acid identity across all bacterial strains
UMAP ...: Target x bacteria amino acid identity matrix projected into two dimensions using UMAP.

species-info

Information on all bacterial strains in the dataset.

ortholog_taxon_id: NCBI taxonomy ID of bacterial strain
ortholog_domain: Domain of bacterial strain
ortholog_kingdom: Kingdom of bacterial strain
ortholog_phylum: Phylum of bacterial strain
ortholog_class: Class of bacterial strain
ortholog_order: Order of bacterial strain
ortholog_family: Family of bacterial strain
ortholog_genus: Genus of bacterial strain
ortholog_species: Species of bacterial strain
ortholog_subspecies: Subspecies of bacterial strain
ortholog_strain: Bacterial strain

inhibitors

Information on ChEMBL inhibitors that engage conserved drug targets.

molecule_chembl_id: Molecule ChEMBL ID of chemical
molecule_name: Name of chemical (from ChEMBL)
molecule_smiles: SMILES of chemical (from ChEMBL)
molecule_inchikey: InChI Key of chemical (from ChEMBL)
is_oral: Is orally-administered drug (from ChEMBL)
is_topical: Is topical drug (from ChEMBL)
is_parenteral: Is parenteral-administered drug (from ChEMBL)
is_orphan: Is orphan drug (from ChEMBL)
is_natural_product: Is a natural product (from ChEMBL)
is_chemical_probe: Is a chemical probe (from ChEMBL)
has_black_box: For drugs, has an FDA black box warning (from ChEMBL)
max_phase: Maximum clinical phase (from ChEMBL)
molecule_chembl_id_2: ChEMBL ID of chemical (from UniChem, redundant)
chembl_url: URL to ChEMBL web page for chemical (from UniChem)
pubchem_id: PubChem ID of chemical (from UniChem)
pubchem_url: PubChem URL of chemical (from UniChem)
drugbank_id: For drugs, DrugBank ID (from UniChem)
drugbank_url: For drugs, DrugBank URL (from UniChem)
vendor_...: Vendor catalog numbers (from UniChem)
..._url: Vendor URLs (from UniChem)
target_taxon_id: NCBI taxonomy ID of source species of canonical drug target
target_organism_name: Source species name of canonical drug target (from ChEMBL)
target_chembl_id: Target ChEMBL ID of canonical drug target
target_name: Name of canonical drug target
assay_chembl_id: Assay ChEMBL ID for assay indicating interaction of chemical with target
assay_type: F = functional; B = binding
assay_target_confidence_score: ChEMBL confidence in accurate target annotation
molecule_target_pchembl: Quantitative assay outcome (usually -log10(IC50 in molar)).