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41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 4.0-75.0, Epilepsy Focal-Onset Seizure Before the start of the trial, to obtain the informed consent approved by the ethics committee voluntarily signed by each subject. For underage subjects, the informed consent jointly signed by the subjects themselves (≥10 years ) and their parents or legal ... | 1 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 18.0-65.0, Glioma Glioma Intracranial Gliomas Benign Brain Tumor Brain Cancer Motor Cortex; Lesion Age 18-65 years old 2. Ability to understand a written informed consent document, and the willingness to sign it 3. Radiographic evidence of likely low-grade glioma on MRI (i.e. non-enhancing) inva... | 0 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 9.0-999.0, Refractory Epilepsy years old or older Diagnosis of epilepsy with focal seizures with or without focal to bilateral tonic clonic seizures (International League Against Epilepsy classification). Diagnosis established by both clinical history and an electroencephalogram (EEG) consistent... | 1 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 18.0-999.0, Refractory Epilepsy adult patients treated between 2010 and 2019 for refractory epilepsy by DBS of the anterior nucleus os the thalamus using microendoscopy minimum follow-up of 1-year refractory epilepsy defined as failure of at least 3 antiepileptic drugs age < 18 years | 1 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 18.0-999.0, Epilepsy Age ≥ 18 years Informed Consent as documented by signature Neurosurgical patient, i.e. patient under surgical care who will undergo one of the following specific procedures Step 1: Patient in the operating room undergoing clinically indicated brain surgery either for resecti... | 1 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 18.0-999.0, Tooth Wear Randomized Controlled Trial Vertical Dimension of Occlusion Composite Resins Generalized moderate to severe tooth wear with patient demand for treatment Full dental arches, one diastema due to one missing posterior tooth was allowed Estimated need for an increase in VDO of... | 0 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 18.0-999.0, Intractable Epilepsy Intractable focal epilepsy with undergoing pre-surgical evaluation intracerebral electrodes implantation in auditory cortices, temporal lobe, superior temporal gyrus, limbic areas, frontal lobe Given Consent to Deafness Pregnancy | 1 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 18.0-100.0, Metastatic Squamous Cell Carcinoma of the Head and Neck (HNSCC) Subjects must be ≥18 years of age. 2. Subjects or their legal representative must be able to provide written informed consent to participate in the trial prior to the performance of any study-specific procedures. 3. Subj... | 0 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 18.0-65.0, Covid19 This study will volunteers household contact of COVID 19 confirmed cases who attend the triage clinic in the participating centers. Included persons should be > 18 years old and below 65 years, without any contraindications for Mefloquine usage • People with history of previo... | 0 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 50.0-85.0, Alzheimer Disease Preclinical Alzheimer's Disease Prodromal Alzheimer's Disease Alzheimer's Disease (Incl Subtypes) Mild Cognitive Impairment Subjects are fully eligible for and have completed the (Amyloid Prediction in early stage Alzheimer's disease from acoustic and linguistic patt... | 0 |
41 year old man with history of severe intellectual disability, CHF, epilepsy presenting with facial twitching on the right and generalized shaking in at his NH which required 20 mg valium to cease seizure activity. Per outside medical patient was felt to have focal epilepsy with secondary generalization, likely due to... | eligible ages (years): 20.0-999.0, Middle Cerebral Artery Stroke Patients with acute MCA infarct (NIHSS > 8) and confirmed by brain MRI studies (excluding lacunar infarct) during hospital admission Patients with prior clinical history of major stroke, significant head injury, brain tumor, major psychiatric illness, p... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 12.0-999.0, Pneumonia, Pneumocystis Carinii HIV Infections Concurrent Medication: Allowed physiologic replacement doses of steroids Pneumocystis carinii pneumonia (PCP) in patient who is HIV positive by ELISA, HIV culture, or p24 antigenemia, or is a member of a risk group for HIV infection Fail... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Pneumonia, Pneumocystis Carinii HIV Infections Patients must have HIV antibody positive CD4 cell counts less than 500/mm3 Adequate general health No significant deterioration in performance status within the past month Prior treatment with a stable regimen of antiretroviral medicatio... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 13.0-999.0, Sarcoma, Kaposi HIV Infections Concurrent Medication: Required Antiretroviral therapy during study treatment only in patients with CD4 count < 500 cells/mm3 (per 12/30/94 amendment). Allowed G-CSF for a second occurrence of grade 3 or 4 neutropenia (per 12/30/94 amendment) Nonsteroid... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 13.0-999.0, Toxoplasmosis, Cerebral HIV Infections Concurrent Medication: Allowed Aerosolized pentamidine for PCP prophylaxis. PER 4/3/96 History of treatment limiting toxicity to pyrimethamine. Patients with a history of treatment limiting toxicity to both pyrimethamine and sulfonamides will be... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, HIV Infections Pregnancy A woman may be eligible for this study if She is HIV-positive She is at least 34 weeks pregnant She has a history of at least 4 weeks of continuous oral ZDV during her current pregnancy and tolerated it well She has given consent for her newborn to participate... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-0.25, HIV Infections Concurrent Medication: Allowed Recommended Standard immunizations. Should repeat MMR 3 months after discontinuing study Benadryl and/or aspirin Pneumocystis carinii pneumonia prophylaxis Systemic ketoconazole and acyclovir, or oral nystatin for acute therapy Aerosol riba... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 13.0-999.0, HIV Infections Histoplasmosis Concurrent Medication: Allowed Vincristine, vinblastine, bleomycin, or interferon for Kaposi's sarcoma Erythropoietin Didanosine by exemption for 10 patients Barbiturates Coumarin-type anticoagulants Oral contraceptives Digoxin Methadone Narcotics Co-ex... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-60.0, Pneumonia, Pneumocystis Carinii HIV Infections Patient must Have Pneumocystis carinii pneumonia (PCP) that has not been treated for current episode. PCP must be documented by observation of > 1 cluster of organisms in sputum, bronchial secretion, or lung tissue Have clinical symptoms ... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 12.0-999.0, Pneumonia, Pneumocystis Carinii HIV Infections Concurrent Medication: Allowed Acetaminophen mg prescribed as necessary for temperature > 38.7 degrees C. Acetaminophen should not be prescribed as a standing order for more than 48 hours. Prior Medication: Allowed Zidovudine (AZT) as lo... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 12.0-999.0, Pneumonia, Pneumocystis Carinii HIV Infections Concurrent Medication: Allowed Acetaminophen 650 mg prescribed as necessary for temperature > 38.7 degrees C. Acetaminophen q4h should not be prescribed as a standing order for more than 48 hours. Prior Medication: Allowed Zidovudine as ... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Inflammation Vasculitis Wegener's Granulomatosis Diagnosis: Wegener's granulomatosis. Age: 10-80 years. Qualifications to Prior documentation of vasculitis based on clinical characteristics and histopathological and/or angiographic evidence of vasculitis. Patients will be eligible for... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Dermatomyositis Inclusion Body Myositis Polymyositis Selected patients should have PM, IBM or DM. Specifically they should have a) proximal muscle weakness; b) no evidence of clinical, histological or family history of another neuromuscular illness; c) elevation of muscle enzymes duri... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Mastocytosis Subjects children and adults from birth to 80 years of age. Participants must have histologic evidence of an increased mast cell number in at least one organ system. Must be willing to be seen at the NIH according to protocol guidelines. Routine medical care must be avail... | 2 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Sjogren's Syndrome Xerostomia Primary Sjogren's Syndrome; symptoms of dry eyes and dry mouth; 6 week period off disease modifying agents, such as antimalarials or steroids. No males. No females with childbearing potential. No patients with hypersensitivity to thalidomide. No confoundi... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 8.0-99.0, Pulmonary Disease Patients 8 years old and older with signs or symptoms of pulmonary disease of medical interest to the professional staff of CPB will be eligible for participation in this protocol. Only standard diagnostic procedures and conventional therapy will be performed. Patient... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-70.0, Mastocytosis Healthy Volunteer Healthy Volunteers must: 1. Be 18-70 years of age 2. Be healthy 3. Have adequate peripheral venous access 4. Have normal renal function (creatinine less than or equal to 1.5mg/dL; less than or equal to 1 plus proteinuria) 5. Have normal hepatic function ... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Atopic Dermatitis Healthy Mastocytosis General: Age equal to or greater than 18. Access to a primary medical care provider outside of the NIH. Able to give informed consent. No history of malignancy or autoimmune disease such as rheumatoid arthritis, vasculitis, pyoderma gangrenosum, ... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Vasculitis Wegener's Granulomatosis Documentation of Wegener's Granulomatosis (WG) based on clinical characteristics and histopathological evidence of vasculitis. Patient with a positive C or P-ANCA and glomerulonephritis as evidenced by the presence of red blood cell casts and protei... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Sjogren's Syndrome Female gender only, ages 18 to 75. Patients should have documented primary Sjogren's syndrome as determined by protocol 84-D-0056. The diagnosis of primary Sjogren's syndrome will be based on the presence of all three of the following: Salivary gland abnormalities; ... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Pneumonia, Pneumocystis Carinii HIV Infections Patients must have the following Clinical diagnosis of acute mild to moderate Pneumocystis carinii pneumonia Dose-limiting intolerance to TMP / SMX or inadequate response to TMP / SMX Willingness and ability to give informed consent. The ... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Graft Versus Host Disease Histologically or clinically proven chronic graft versus host disease (GVHD) that has failed to respond to at least 1 month of treatment with the following: Steroids (greater than 0.5 mg/kg/day) AND Cyclosporine or a cytotoxic agent (azathioprine or mercaptop... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 8.0-999.0, Angioedema ENTRY --Disease Characteristics-- Confirmed diagnosis of hereditary angioedema (HAE) based upon C4 antigenic level, positive family history, and C1 inhibitor (C1INH) antigenic level (Type I HAE) or functional level (Type II HAE) Functional C1 within normal levels if diagnos... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 2.0-80.0, Mastocytosis Ages greater than or equal to 2 to 80. Wt greater than 40 kg. Patients with systemic mastocytosis proven by a bone marrow biopsy and one of the following: Category I disease with poor prognosis secondary to extensive bone marrow involvement of mast cells (i.e. greater than... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 13.0-999.0, Lupus Erythematosus, Systemic A diagnosis of systemic lupus erythematosus | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Chronic Granulomatous Disease The following conditions must be met before a patient may be enrolled in the study: Patients ages 2 to 17 years; minimum weight of 12 kg. DHR proven chronic granulomatous disease with gp91 phox or p22 phox deficiency. History of at least one life-threaten... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Recurrent Melanoma Stage IV Melanoma Histologically or cytologically confirmed stage IV melanoma At least 1 measurable lesion Greater than 20 mm by conventional techniques Greater than 10 mm by spiral CT scan Known brain metastases allowed if all of the following are met Radiological... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 2.0-80.0, Mastocytosis Monoclonal Bone Marrow Tryptase Two to 80 years of age. Histologic evidence of increased mast cell number by bone marrow and/or skin biopsy or documentation of mastocytosis in the skin supported with a photograph of diagnostic skin lesion Must be under the care of a primar... | 2 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-45.0, Depression Mothers and infants must meet certain to be included in the study. Selection are: maternal age between 20 and 45 years, ability to read and write in English, normal pregnancy/delivery status without birth complications, term birth (+/ days from due date), and singleton statu... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 2.0-100.0, Eosinophilic Myeloid Neoplasm Hypereosinophilic Syndrome All subjects must meet the established diagnostic for hypereosinophilic syndrome: eosinophilia greater than 1,500/mm(3) on two occasions, no secondary etiology for the eosinophilia despite careful clinical evaluation, and eviden... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Mastocytosis Anaphylaxis FOR WITH Age equal to or greater than 18 years. Diagnosis of mastocytosis established by presence of typical urticaria pigmentosa skin lesions or a bone marrow biopsy. Letter of referral from prospective study participant's local doctor. Ability to give inform... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-21.0, Mastocytosis Children with tissue-diagnosed pediatric-onset mastocytosis formerly enrolled in protocols 90-I-0120, and 93-I-0136 or per physician referral with more severe disease as indicated by one of the following parameters Hepatomegaly or splenomegaly Diffuse cutaneous mastocytosi... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Alcohol Consumption Subjects who are included: 1. will be between the ages of 21 and 25. 2. will have a score on the telephone administered SRE at least one standard deviation above the mean, in the case of subjects to be evaluated further as potential Low-Response group participants.... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Crohn Disease Patients must meet each of the following to be eligible for enrollment in this study. 1. Patients with Crohn's disease of at least 6 months duration (with colitis, ileitis, or ileocolitis) confirmed by radiography or endoscopy. 2. Patient must have a CDAI score less than... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Osteoporosis Female, 5 years postmenopause Ambulatory Community dwelling Able to ingest calcium and vitamin D supplements Willing to restrict vitamin K intake Stable thyroid dose if appropriate No history of hyperthyroidism, hyperparathyroidism or other metabolic bone diseases Absence... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-75.0, Hypereosinophilia Hypereosinophilic Syndrome Documented history of Hypereosinophilic Syndrome (HES) Eosinophil count greater than 1500 cells for 6 months Signs and symptoms of organ system involvement No evidence of parasitic, allergic or other causes of eosinophilia after comprehensi... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, GITR GITR Ligand Uveitis Immunosuppression Suppressor of Cytokine Secretion Patients with bilateral sight threatening uveitis requiring systemic immunotherapy who are 18 years and older are eligible. Disease can be active or quiescent, but subjects must be on a minimum prescribed the... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Kidney Neoplasms CELL Patients must have metastatic renal cell cancer age greater than or equal to 18 years Clinical performance status of Eastern Cooperative Oncology Group (ECOG) 0, 1 at entry to the trial Life expectancy of greater than three months Seronegative for human immunode... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Malignant Carcinoid Syndrome Histologically confirmed diagnosis of a neuroendocrine tumor of the carcinoid type Documented evidence of carcinoid syndrome (flushing and/or diarrhea) attributable to a primary tumor of the lung, stomach or mid-gut Previous positive Octreoscan World Heal... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Clear Cell Renal Cell Carcinoma Recurrent Renal Cell Cancer Stage III Renal Cell Cancer Stage IV Renal Cell Cancer Patients must have histologically or cytologically confirmed renal cell carcinoma which is either metastatic (M1) or unresectable (M0); patients must have a component of ... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Stomatitis Male or female patients ages > 18 yrs Patients undergoing high dose chemotherapy with or without radiation therapy treatment as conditioning for autologous hematopoietic stem cell transplantation. The conditioning regimens at least one of the following: high dose melphalan... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Systemic Lupus Erythematosus Has SLE by ACR revised (meets <4 criteria) Has SLE with at least one elevated lupus antibody Has new onset of severe lupus disease flare in at least one body or organ system, excluding renal or neurologic Active severe CNS or Renal disease defined by BIL... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 10.0-70.0, Crohn's Disease 70 years-old., Weigh 20-100 kg (44-220 lbs) CD of the ileum, colon or ileocolon, verified by colonoscopy, barium enema, or small bowel series performed within 36 months Perianal fistulae will be eligible provided that the perianal disease does not account for the prepo... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Lupus Erythematosus, Systemic Has SLE by American College of Rheumatology revised (meets >/= 4 criteria) Has had SLE for at least 6 months prior to study entry Has at least one elevated autoantibody level at study entry Has moderately active SLE disease at study entry in any body/org... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-50.0, Asthma Healthy Asthmatic Subjects Clinical diagnosis of asthma Steroid naive or subjects not using their inhaled steroids for the last 4 weeks, short-acting beta-agonist for rescue medication FEV1 > 70% of predicted Positive skin prick test for house dust mite, cat or grass pollen PC2... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Systemic Lupus Erythematosus participants must be diagnosed with SLE and be experiencing an active lupus flare in at least one of three organ systems: skin (discoid lesions), inflammation of the lining of the heart (pericarditis), or inflammation of the lining of the lung (pleuritis/... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Chronic Myeloproliferative Disorders Leukemia Lymphoma Nonneoplastic Condition Precancerous Condition Histologically confirmed systemic mastocytosis Objective evidence of disease, as defined by the following Hemoglobin < 10 g/dL Recurrent mast cell mediator-release symptoms that impa... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 40.0-85.0, Cardiovascular Disease Outpatients who are required a combination therapy with sitting systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg Outpatients aged over 40 years and less than 85 years (inclusive), regardless of sex Previously untreated patients or patient... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-30.0, Fasting Healthy lean women (with body mass indices [BMI] < 25 kg/m2) Overweight otherwise healthy men (with BMI > 27 kg/m2) Overweight otherwise healthy women (with BMI > 27 kg/m2) A history of any illness that may affect the concentrations of the hormones to be studied, e.g. infecti... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Head and Neck Cancer Patients must have documented advanced, locally recurrent, or metastatic head and neck carcinoma, which is untreatable by surgical resection or radiation therapy Prior chemotherapy for advanced/metastatic disease is allowed (1 regimen only) Patients must be taxan... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 45.0-999.0, Osteoporosis Women who are postmenopausal with at least one year since the last menstruation Women who are 45-54 years of age with the following bone mineral density (BMD) and/or vertebral fracture BMD 3.0 standard deviations (SDs) or more below peak bone mass of young females at the... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Osteoarthritis Peptic Ulcer Must require the chronic use of a non-steroidal anti-inflammatory drug for the treatment of osteoarthritis Must be taking daily aspirin for cardiovascular prophylaxis Clinical Laboratory values within normal limits for this population History of gastric, ... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Arthritis Arthroscopic Hip Surgery primary THA (cemented or cementless) preoperative diagnosis of osteoarthritis (primary or secondary) meets objective discharge-to-home test following hip replacement ability to speak English and reply to questionnaires written in English ability to p... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-76.0, Leukemia, Mast-Cell Mantle-cell Lymphoma Recipient Between 18 and 76 years of age Chronic lymphocytic leukemia (CLL) Unmutated IgG VH gene status Mutated IgG VH genes (> 2% nucleotide change compared to somatic sequence) Complete remission benefit most from allogeneic hematopoietic st... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Nasal Polyps Gastroesophageal Reflux Subjects will Be adults with nasal polyposis recruited from the PI's private practice Not be currently taking a PPI Be able and willing to undergo a noninvasive 24 hour pH probe study; and Take a PPI Patients who Are pregnant Have a history of su... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Recurrent Melanoma Recurrent Renal Cell Cancer Stage III Melanoma Stage IV Melanoma Stage IV Renal Cell Cancer Histologically confirmed diagnosis of 1 of the following Melanoma Unresectable stage III disease Stage IV disease Renal cell carcinoma Unresectable and/or stage IV disease M... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Systemic Mastocytosis, Aggressive (ASM) Leukemia, Mast Cell Hematological Non-mast Cell Lineage Disease (AHNMD) At least 18 years of age Karnofsky performance status (KPS) of > 30% (equivalent to ECOG 0 to 3) Mast cell disease, histologically confirmed and documented to be Aggressive... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Breast Cancer Signed informed consent, premenopausal women 18 years or older, histologically or cytologically confirmed locally advanced or metastatic breast cancer, suitable for endocrine treatment, no curative treatment available,, one or more measurable lesions, life expectancy mo... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-80.0, Arthritis, Rheumatoid Previous diagnosis of RA according to the revised 1987 of the American Rheumatism Association (Arnett et al., 1988) patients must have a minimum of 8 tender and 4 swollen joints with disease diagnosed at least 3 months prior to screening patients must have been u... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 20.0-70.0, Non-Hodgkin's Lymphoma Histologically proven NHL, and for which intensive chemotherapy is considered treatment-of-choice. 2. HBsAg-positive. 3. No previous chemotherapy and radiotherapy. 4. No concurrent radiotherapy. AGC ≧ 2,000/mm3, Platelet ≧ 100,000/mm3 of peripheral blood. 5. Tot... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 8.0-999.0, Sickle Cell Disease Vaso-occlusive Crisis Sickle cell and acute pain Age 8 and up English or Spanish-speaking Fever greater than 101 Acute chest syndrome or pneumonia Other SS complications (sequestration, aplastic crisis) Other explanation for pain (chronic, AVN, surgical) History o... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-75.0, Anemia Acquired Immunodeficiency Syndrome Patients with a confirmed diagnosis of AIDS, exhibiting signs and symptoms of AIDS characterized by lymphocytopenia (decrease in the number of lymphocytes [cells that are typical elements of lymph tissue] in the blood) as determined by a findi... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 15.0-70.0, Autoimmune Thyroiditis Hashimotos Thyroiditis Clinically approved AIT patients who do not use any medication other than LT4 to keep TSH in the lower half of normal range Any kind of drug use other than LT4 or any kind of known pathology which may effect GIS absorption | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Kidney Diseases Patients undergoing a single renal transplant from deceased or living donor Adults 18 years and older First or second renal transplant Capable of understanding the purposes of the study, has given written informed consent, and agrees to comply with the study requireme... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-90.0, Abscess Cysts Female or male, aged between 18 and 90 years Written informed consent Abscess formation or abdominal cyst scheduled to drainage Plasma creatinine <1.5 mg/dL Pregnancy or lactation Hemodialysis or hemofiltration Allergy or hypersensitivity against study drugs Massive ede... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-60.0, Rheumatoid Arthritis Participant Age > 18 and < 60 years at time of pre-transplant evaluation An established clinical diagnosis of rheumatoid arthritis by American College of Rheumatology criteria Patients must have failed an autologous hematopoietic transplant or have failed to respo... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-72.0, Liver Cirrhosis Liver Transplant Disorder Male and female patients between 18 and 72 years of age Male or female patients who are primary cadaveric liver transplant recipients Cold ischemia time must be <20 hours Females capable of becoming pregnant must have a negative pregnancy test... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 13.0-65.0, Pneumonia, Interstitial Plasma Cell Pneumocystis Carinii Pneumonia Pneumonia, Pneumocystis Carinii HIV Infections Documented or presumptive HIV infection Signs and symptoms of PCP present for at least 5 days Pneumocystis jiroveci confirmed in BAL fluid or induced sputum sample Suitabl... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-65.0, Breast Neoplasms Fibrocystic Disease of Breast Mammaplasty first visit to a Breast Disease Ambulance for consultation no pregnancy no severe heart disease (EF > 40%) no therapy with digitalis no acute/chronic inflammatory disease (e.g. RA, M. Crohn) no dysfunction of the Hypothalamo-... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Hypercholesterolemia Patients are eligible for study entry based on the following 1. Males or females greater than or equal to 18 years of age 2. Females must not be pregnant or lactating. Females of childbearing potential and males must use a reliable means of contraception. 3. LDL-... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-39.0, McCune-Albright Syndrome Children with MAS ranging from toddlers to young adults Diagnosis of MAS will be made on a clinical basis. Blood testing is not helpful in this condition, as bone marrow progenitor cells with the Gαs mutation display a survival disadvantage. All patients are mi... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-999.0, Mastocytosis Confirmed or suspected diagnosis of mastocytosis Ability to give informed consent (by the patient or legal guardian if minor) Inability or not willing to provide informed consent | 2 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Cancer of Head and Neck Histologically proved locally advanced squamous cell carcinoma of the head and neck of all primary sites. The following TNM stages by sites will be eligible.Oral cavity, Pharynx, Larynx, Nasopharynx, paranasal sinuses, Oral cavity, Pharynx, Larynx, Nasopharynx... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-90.0, Heart Failure, Congestive Patients hospitalized due to decompensated heart failure who require IV inotropic and/or vasodilator and diuretic therapy 2. Patients receiving appropriate medical therapy for heart failure, defined as ACE inhibitors and beta blockers (all unless not tolerate... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 3.0-10.0, Myocardial Repolarization Health children (ASA I-II) undergoing procedures that require general anesthesia without pre-medication Children with long QT syndrome, a family history of long QT syndrome or taking medication that is known to prolong the QT interval IV access unobtainable p... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 12.0-65.0, Asthma Will meet American Thoracic Society for asthma 2. Pulmonary function tests consistent with asthma. This includes a baseline FEV1 < 80% predicted as well as a 12% improvement in FEV1 following up to 4 puffs of albuterol. 3. Subjects must be 12 to 65 years old Viral infection wi... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Low Back Pain At least 18 years of age History of chronic, function-limiting low back pain of at least 6 months duration Able to give voluntary, written informed consent to participate Able to understand the investigation, cooperate with the procedures, and willing to return for foll... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 0.0-0.096, Vitamin D Deficiency Healthy singleton term born infants of appropriate size for gestational age (AGA) according to the Centers for Disease Control growth charts based on weight at birth between the 5th and 95th percentiles for sex; and born to healthy breastfeeding women. This allows... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Pain, Postoperative Over 18 years old Scheduled (within two weeks of the screening visit) to undergo elective orthopedic surgery (e.g., bunionectomy, arthroscopic knee surgery, rotator cuff repair) Moderate to severe pain within 8 hours following completion of the required surgery P... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Breast Neoplasms Patients with histologically confirmed HER-2/neu-overexpressing adenocarcinoma of the breast; this is defined as HER-2+ by immunohistochemistry (IHC) 3+ staining or Fluorescence In-Situ Hybridization (FISH). Prior adjuvant Trastuzumab therapy is permitted. Patients m... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Post-surgical Inflammation Patients scheduled for cataract extraction Under 18 years | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Acute Coronary Syndrome Patients who have undergone PCI within the preceding 72 hrs 2. Patients on aspirin and clopidogrel 3. Age greater than 18 years and less than 80 years 4. Written informed consent Active bleeding 2. Pregnancy 3. Patients already on H2 antagonists 4. Patients a... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-70.0, Renal Transplantation Primary donor kidney transplant Panel reactive antibody (PRA) ≤ 20% Multi-organ transplantation including dual kidneys or previous transplant with any other organ different from kidney Non-heart beating donor or kidney from a non-compatible donor Other protocol-... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Cystic Fibrosis Phlebitis Diagnosis of cystic fibrosis, made accordingly to the Cystic Fibrosis Foundation Guideline (Rosenstein BJ. J Pediatr 1998;132: 589-595) age of 18 years or more and ability to consciously express owns informed consent have a prescription done by one of the CF... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-80.0, Pemphigus Vulgaris Histologic evidence compatible with pemphigus vulgaris and direct immunofluorescence evidence of pemphigus vulgaris Chronic disease that has been controlled with steroids and/or cytotoxics, e.g. maintenance phase On prednisone 15 or more mg/day to around 40 mg/day o... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Hypertension Aged over 18 years Hypertension (essential or secondary) managed in Sheffield Hypertension Clinic or general practice or both Blood pressures not adequately controlled (systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) >85 mmHg in clinic and o... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-50.0, Healthy Healthy subjects (Men or women of nonchildbearing potential ), aged 18 to 50 years Body mass index in the range of 18 to 30 Kg/m2 and body weight greater than 50 Kg Healthy as determined by the investigator on the basis of medical history, physical examination, clinical labora... | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Systemic Mastocytosis Patients with SM; including mast cell leukemia. 2. Age >/= 18 years 3. Minimum of two weeks since any major surgery or completion of radiation. 4. Eastern Cooperative Oncology Group (ECOG) performance status </= 2 5. Adequate liver function as shown by serum bil... | 1 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Graft Rejection Low risk keratoplasty High risk keratoplasty | 0 |
Pt is a 22yo F otherwise healthy with a 5 yr history of the systemic mastocytosis, with flares normally 3/year, presenting with flushing and tachycardia concerning for another flare. This is patient's 3rd flare in 2 months, while still on steroid taper which is new for her. She responded well to 125 mg IV steroids q 8 ... | eligible ages (years): 18.0-999.0, Coronary Artery Disease Drug Resistance Patients undergoing elective coronary stenting Pretreatment with a bolus dose of 600mg of clopidogrel prior to coronary stent implantation Pretreatment with aspirin ≥ 100 mg per day for at least 7 days Age > 18 years Written consent Troponin T... | 0 |
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