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5. TruSeq adapter, index 4
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG
6. TruSeq adapter, index 5
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG
7. TruSeq adapter, index 6
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG
8. TruSeq adapter, index 7
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG
9. TruSeq adapter, index 8
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACACTTGAATCTCGTATGCCGTCTTCTGCTTG
10. TruSeq adapter, index 9
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACGATCAGATCTCGTATGCCGTCTTCTGCTTG
11. TruSeq adapter, index 10
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACTAGCTTATCTCGTATGCCGTCTTCTGCTTG
12. TruSeq adapter, index 11
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACGGCTACATCTCGTATGCCGTCTTCTGCTTG
13. TruSeq adapter, index 12
Source sequence:
GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG
14. QP1 primer
Source sequence:
AATGATACGGCGACCACCGA
15. QP2 primer
Source sequence:
CAAGCAGAAGACGGCATACGA
Step-by-step library generation
Step 1. Single-cell lysis
Input substrate:
* one isolated cell
Added oligos/reagents:
* lysis buffer
* protease
Molecular event:
The single cell is lysed in a small-volume reaction, releasing genomic DNA in the same tube used for downstream library construction.
Product structure:
* released genomic DNA from one cell
Step 2. Lambda spike-in and MspI digestion
Input substrate:
* released genomic DNA
Added oligos/reagents:
* unmethylated lambda DNA spike-in
* MspI restriction enzyme
* Tango buffer