image imagewidth (px) 430 2.22k | id stringlengths 13 16 | study_sid stringlengths 7 9 | study_name stringlengths 7 20 | pmid stringlengths 6 8 | reference_title stringlengths 32 150 | substances listlengths 0 11 | figure stringclasses 10
values | paper_content_type stringclasses 2
values | paper_text stringlengths 2.23k 98.1k | paper_pdf stringlengths 11 13 | n_timecourses int64 1 20 | timecourses_json stringlengths 951 23k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1623898__Fig2 | 1623898 | Sindrup1992 | 1623898 | The effect of quinidine on the analgesic effect of codeine. | [
"codeine",
"morphine",
"quinidine",
"sparteine",
"sparteine sulfate",
"2-dehydrosparteine",
"5-dehydrosparteine"
] | Fig2 | fulltext_pdf | Eur J Clin Pharmacol (1992) 42:587-592
European J .... Io, (~[~1~(~@~
© Springer-Verlag 1992
The effect of quinidine on the analgesic effect of codeine
S. H. Sindrup I , L. Arendt-Nielsen 2, K. Brosen 1 , P. Bj erring 3 , H. R. Angelo 4, B. Eriksen 5 , and L. F. Gram s
Department of Cli~ical Pharmacology, Odense U... | 1623898.pdf | 6 | [{"substance": "codeine", "intervention": "COD", "tissue": "plasma", "group": "all", "label": "codeine_COD", "measurement_type": "concentration", "time_unit": "hr", "value_unit": "nmol/l", "points": [{"time": 1, "mean": 301.615230625, "sd": 181.729142076342}, {"time": 2, "mean": 372.794100625, "sd": 145.683071725233}, ... | |
17541571__Fig1 | 17541571 | Villesen2007b | 17541571 | Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers. | [
"morphine-6-glucuronide",
"paracetamol",
"morphine",
"morphine-3-glucuronide",
"sulfapyridine"
] | Fig1 | fulltext_pdf | PHARMACOKINETICS AND DISPOSITION
Pharmacokinetics of morphine-6-glucuronide following oral
administration in healthy volunteers
Hanne H. Villesen & Kim Kristensen & Steen H. Hansen &
Niels-Henrik Jensen & Ulrik Skram & Lona L. Christrup
Received: 6 October 2006 / Accepted: 22 March 2007 / Published online: 31 May 2007
... | 17541571.pdf | 16 | [{"substance": "morphine-6-glucuronide", "intervention": "M6G_200, SUL, APAP", "tissue": "plasma", "label": "S1_200M6G", "measurement_type": "concentration", "time_unit": "hr", "value_unit": "nmol/l", "points": [{"time": 0.71991, "mean": 169.29134, "value": 169.29134}, {"time": 0.71991, "mean": 188.18898, "value": 188.... | |
17541571__Fig2 | 17541571 | Villesen2007b | 17541571 | Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers. | [
"morphine-6-glucuronide",
"paracetamol",
"morphine",
"morphine-3-glucuronide",
"sulfapyridine"
] | Fig2 | fulltext_pdf | PHARMACOKINETICS AND DISPOSITION
Pharmacokinetics of morphine-6-glucuronide following oral
administration in healthy volunteers
Hanne H. Villesen & Kim Kristensen & Steen H. Hansen &
Niels-Henrik Jensen & Ulrik Skram & Lona L. Christrup
Received: 6 October 2006 / Accepted: 22 March 2007 / Published online: 31 May 2007
... | 17541571.pdf | 5 | [{"substance": "morphine-3-glucuronide", "intervention": "M6G_200, SUL, APAP", "tissue": "plasma", "group": "all", "label": "morphine-3-glucuronide_200M6G", "measurement_type": "concentration", "time_unit": "hr", "value_unit": "nmol/l", "points": [{"time": 3.55e-15, "mean": 1.742491, "value": 1.742491, "sd": "na"}, {"t... | |
17541571__Fig3 | 17541571 | Villesen2007b | 17541571 | Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers. | [
"morphine-6-glucuronide",
"paracetamol",
"morphine",
"morphine-3-glucuronide",
"sulfapyridine"
] | Fig3 | fulltext_pdf | PHARMACOKINETICS AND DISPOSITION
Pharmacokinetics of morphine-6-glucuronide following oral
administration in healthy volunteers
Hanne H. Villesen & Kim Kristensen & Steen H. Hansen &
Niels-Henrik Jensen & Ulrik Skram & Lona L. Christrup
Received: 6 October 2006 / Accepted: 22 March 2007 / Published online: 31 May 2007
... | 17541571.pdf | 20 | [{"substance": "morphine", "intervention": "M6G_200, SUL, APAP", "tissue": "plasma", "label": "S4_morphine", "measurement_type": "concentration", "time_unit": "hr", "value_unit": "nmol/l", "points": [{"time": 5.0615597, "mean": 0.6636175, "value": 0.6636175}, {"time": 5.882353, "mean": 1.5021466, "value": 1.5021466}, {... | |
7002186__Fig1 | 7002186 | Prescott1980 | 7002186 | Kinetics and metabolism of paracetamol and phenacetin. | [] | Fig1 | fulltext_pdf | "Br.J.clin.Pharmac.(1980),10,291S-298S\nKINETICSAND METABOLISM\nOFPARACETAMOL AND PHENACETIN\nL.F.PR(...TRUNCATED) | 7002186.pdf | 3 | "[{\"substance\": \"apapglu\", \"intervention\": \"apap_20mgkg_po\", \"tissue\": \"plasma\", \"group(...TRUNCATED) | |
7002186__Fig4 | 7002186 | Prescott1980 | 7002186 | Kinetics and metabolism of paracetamol and phenacetin. | [] | Fig4 | fulltext_pdf | "Br.J.clin.Pharmac.(1980),10,291S-298S\nKINETICSAND METABOLISM\nOFPARACETAMOL AND PHENACETIN\nL.F.PR(...TRUNCATED) | 7002186.pdf | 5 | "[{\"substance\": \"apapcys\", \"intervention\": \"apap_20mgkg_po\", \"tissue\": \"urine\", \"group\(...TRUNCATED) | |
7002186__Fig6 | 7002186 | Prescott1980 | 7002186 | Kinetics and metabolism of paracetamol and phenacetin. | [] | Fig6 | fulltext_pdf | "Br.J.clin.Pharmac.(1980),10,291S-298S\nKINETICSAND METABOLISM\nOFPARACETAMOL AND PHENACETIN\nL.F.PR(...TRUNCATED) | 7002186.pdf | 2 | "[{\"substance\": \"paracetamol\", \"intervention\": \"apap_12mgkg_iv\", \"tissue\": \"plasma\", \"g(...TRUNCATED) | |
7002186__Fig7 | 7002186 | Prescott1980 | 7002186 | Kinetics and metabolism of paracetamol and phenacetin. | [] | Fig7 | fulltext_pdf | "Br.J.clin.Pharmac.(1980),10,291S-298S\nKINETICSAND METABOLISM\nOFPARACETAMOL AND PHENACETIN\nL.F.PR(...TRUNCATED) | 7002186.pdf | 5 | "[{\"substance\": \"apapcys\", \"intervention\": \"apap_20mgkg_po\", \"tissue\": \"urine\", \"group\(...TRUNCATED) | |
7983238__Fig1 | 7983238 | Band1994 | 7983238 | "Human pharmacokinetic study of immediate-release (codeine phosphate) and sustained-release (codeine(...TRUNCATED) | [
"codeine",
"codeine phosphate"
] | Fig1 | fulltext_pdf | "Codeine Contin® (codeine controlled release tablets) Page 1 of 45 \n \n \n \n \n \n \n \n \n \nPR(...TRUNCATED) | 7983238.pdf | 3 | "[{\"substance\": \"codeine\", \"intervention\": \"COD_IRC\", \"tissue\": \"plasma\", \"group\": \"a(...TRUNCATED) | |
PKDB00021__Fig2 | PKDB00021 | Shinoda2007 | 17202677 | "Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain(...TRUNCATED) | [
"paracetamol",
"paracetamol glucuronide",
"paracetamol sulfate",
"paracetamol cysteine"
] | Fig2 | fulltext_pdf | "Pharmaceutical Society of Japan\nNII-Electronic Library Service\nPharmaceuticalSociety of Japan\n(...TRUNCATED) | PKDB00021.pdf | 4 | "[{\"substance\": \"paracetamol\", \"intervention\": \"paracetamol1000mg\", \"tissue\": \"plasma\", (...TRUNCATED) |
End of preview. Expand in Data Studio
PK-DB Graph → Timecourse Benchmark
Each entry is one pharmacokinetic figure (graph) + the full text of its source paper, paired with the timecourses digitized from that figure.
input = figure image + paper_text (full article)
target = timecourses[] (per curve: substance, intervention, tissue, group,
n, time_unit, value_unit, and the (time, value) points)
Load
from datasets import load_dataset
ds = load_dataset("imagefolder", data_dir=".") # split: 'test'
ex = ds["test"][0]
ex["image"] # PIL figure
ex["paper_text"] # full paper text
import json; json.loads(ex["timecourses_json"]) # target series
Columns
| column | description |
|---|---|
image |
figure image (input) |
paper_text |
full paper text (input); paper_content_type = fulltext_pdf/abstract |
paper_pdf |
filename under papers/ of the original PDF |
timecourses_json |
JSON string: list of curves, each with substance/intervention/tissue/group/count/units/points (target) |
id, study_sid, study_name, pmid, reference_title, substances, figure, n_timecourses |
provenance |
papers/ holds the original PDFs and extracted .txt/.md for each study.
Statistics
- Entries (figures): 39 across 23 studies (single
testsplit) - Paper content: 38 full-text, 1 abstract-only
- Timecourses: 216 · (time, value) points: 2830
Why the paper is included
Timecourse values come from PK-DB curators' figure digitization (original paper units). Fields like subject n, the SD-vs-SE distinction, the intervention dose/route, and sometimes the unit are not visible in the graph and must be read from the paper — so the full text is bundled as input.
Source, license & attribution
Figures + digitized data: PK-DB, open-licence studies
(Grzegorzewski et al., Nucleic Acids Res. 2021, doi:10.1093/nar/gkaa990).
Paper text/PDFs are the property of their original publishers (see each pmid)
and are included here for research use; respect the publishers' terms. Attribution
to PK-DB and the primary publications is required. See LICENSE.
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