title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Theory of EEG potential in a model of the thin membranes of the brain]. | The methods of estimating a momentary value of the epidural potential using several values of EEG, sampled at the same instant, are explored theoretically. The weights of the summation of these EEG-potentials for the case of simple disposition of electrodes, are single-valued by means of elementary consideration of the... | 444,611 | [
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[Calorimetric study of heat denaturation of beta-trypsin]. | Thermal denaturation of beta-trypsin was studied by scanning microcalorimetry. It is shown that the denaturational transition is well described by the one-step model of transition between two macroscopic states. The specific enthalpy of denaturation is a linear function of temperature, the extrapolation to 110 degrees ... | 444,619 | [
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Chromosome survey of newborn infants in Tokyo: follow-up study for XYY. | In order to ascertain the frequency of chromosome aberrations among newborn infants in Japan, a chromosome survey of a large number of newborn infants is in progress. A series of 10,270 consecutive newborn babies, 5,341 male and 4,929 female, have been screened for clinical manifestations of autosomal aberrations and f... | 444,639 | [
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Lymphocyte-mediated lysis of antibody coated human red cells in the presence of human serum. | When peripheral blood lymphocytes and human red cells coated with IgG were incubated in vitro in culture medium, antibody-dependent lymphocyte-mediated lysis was observed. This lysis was markedly inhibited by the addition of purified monoclonal IgG1 (1000 microgram/ml) to the culture medium. In contrast, lysis by lymph... | 444,657 | [
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Polycythemia vera: electron microscopy of the bone marrow in 10 non-treated patients. A thin section and freeze-fracture study. | Electron microscopy (thin sections and freeze-fracture replicas) was performed on the bone marrow of ten patients with Polycythemia vera prior to any treatment. In addition to a hyperplasia of all three cell lineages and the sinuses, atypias were observed in the maturing erythroblasts. These aberrations of normal devel... | 444,680 | [
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Mercury residues in tissues of dead and surviving birds fed methylmercury. | Concentrations of mercury in passerine birds fed diets containing 40 ppm methylmercury were similar in tissues of birds that died from mercury poisoning and in those that were sacrificed after half the group had died. Residues were higher in tissues of birds that died, but the differences were not statistically signifi... | 444,688 | [
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The effect of temperature on copper tolerance of Paramecium. | The copper tolerance of paramecium tetraurelia decreases with increased temperatures over the range of 12 C to 34 C. The relationship is linear and the correlation = - 0.98. The regression equation has an intercept of 16 micro M Cu++ at O C, and tolerance is reduced by 0.33 micro M for each degree increase in temperatu... | 444,691 | [
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Screening of common bacteria capable of demethylation of methylmercuric chloride. | In summary, 21 bacteria were capable or degrading methylmercury chloride as measured by the disappearance of that species from the soil culture media. Disappearance of the methylated form was also accompanied by loss of total mercury in the culture media--probably as a result of reduction of the initial metabolite to v... | 444,703 | [
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Heavy metal levels in feathers of wild turkeys from Virginia. | Levels of lead, cadmium, nickel, and zinc were determined in feathers of 175 wild turkeys (Meleagris gallopava) shot by hunters in 19 Virginia counties in 2 physiographic regions. Lead and nickel levels did not vary by county, region, sex, or age. Zinc and cadmium levels were significantly (P less than 0.01) higher in ... | 444,755 | [
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The radiological diagnosis of polyps in the presence of diverticular disease. | The double contrast barium enemas in 20 patients with endoscopically proven polyps within a segment of diverticular disease have been reviewed. Ninety per cent of the polyps were detected. The increased density sign and negative shadow filling defect proved valuable in their detection. Antispasmodics are advised to dis... | 444,816 | [
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Ultrasound in the evaluation and diagnosis of jaundice. | Our experience in the evaluation and diagnosis of jaundice by ultrasound in a consecutive series of patients examined in the past year is reported. A final diagnosis is available in 49 patients with obstructive jaundice and 41 patients with nonobstructive jaundice. The accuracy of separation into these two groups is 97... | 444,819 | [
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Hospital resuscitation from ventricular fibrillation in Brighton. | The overall results over three and a half years of the treatment of ventricular fibrillation secondary to ischaemic heart disease in the Royal Sussex County Hospital were reviewed. Records of all patients who were brought to hospital by resuscitation ambulances or who were admitted to the coronary care unit from any so... | 444,862 | [
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Comparison of central nervous system malformations in spontaneous absortions in Northern Ireland and south-east England. | A study of 1140 pregnancies ending in spontaneous abortion disclosed a central nervous system (CNS) malformation in 4.9% of all complete conceptuses. Life-table analysis suggested that the incidence of CNS malformations is 16/1000 at the beginning of the eighth week of gestation. It was also estimated that only one-fif... | 445,098 | [
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Vaccination for herpes simplex genitalis. | Type-specific vaccines containing heat-inactivated herpes simplex hominis virus type 1 or 2 have been developed for the treatment of herpes simplex genitalis. When patients with recurrent herpes genitalis were treated with the type 2 vaccine the clinical course of the disease improved and the eruption-free interval was... | 445,121 | [
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The effects of periarterial nerve activation on coronary vessel tone in an isolated and perfused slab of beef ventricle. | The direct effects of extrinsic nerve stimulation on coronary artery tone are unclear because of the complications arising from alterations in myocardial dynamics which themselves alter flow. An isolated and perfused nonbeating slab of beef ventricle was utilized in the present experiments to eliminate secondary compli... | 445,230 | [
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Neonatal respiratory distress: potential for prevention. | A prospective study was conducted of 100 consecutive admissions to the neonatal intensive care unit of the Hospital for Sick Children, Toronto, of infants with respiratory distress syndrome or transient tachypnea of the newborn. It was found that in 15% of cases the illness was completely preventable, being the result ... | 445,301 | [
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Early diagnosis of ovarian cancer. | Ovarian cancer is the most common fatal gynecologic malignant disease. Unfortunately 60% to 70% of patients present initially with advanced disease. Progress in the treatment of this condition will be made only if it can be diagnosed early. Pelvic examination is still the best screening test despite attempts to make an... | 445,304 | [
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Long term follow-up of combination chemotherapy-radiotherapy of stage III Hodgkin's disease: a Cancer and Acute Leukemia Group B study. | The Cancer and Acute Leukemia Group B studied the effect of combination chemotherapy-radiotherapy on Stage III Hodgkin's disease. Chemotherapy consisting of 4 weekly doses of vinblastine and one dose of mechlorethamine hydrochloride was followed by no therapy (CT), radiation to involved fields (CTIF) or total nodal rad... | 445,326 | [
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Adenoma of parotid gland with sebaceous and oncocytic features. | A parotid tumor having sebaceous differentiation and a particular histologic picture previously undescribed is reported. The tumor showed features of an adenolymphoma but almost completely lacked a lymphoid component. Sebaceous differentiation was seen in the epithelium of many cysts. Additionally, groups of oxyphilic ... | 445,340 | [
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Pulmonary neoplasms diagnosed with transthoracic needle biopsy. | Results of transthoracic needle biopsy have been evaluated on the basis of fourteen years experience comprising 5300 procedures on 2726 patients. In 90.7% of the cases a diagnosis was established. Of these, 46.4% showed cytological evidence of primary or secondary malignancy. In 2.4% false positives and in 3% false neg... | 445,349 | [
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Screening for breast atypias using exfoliative cytology. | A sample of 1744 self-selected, mostly asymptomatic women was used to evaluate exfoliative cytology of nipple secretions as a screening technique for breast atypias. Results indicated: 1) overall frequency of breast fluid recovery was 49%, and related to age, phase of reproductive life, parity, history of lactation and... | 445,368 | [
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Growth rates of primary breast cancers. | The growth rates of breast cancers are a critical aspect of the natural history of the disease. Growth rates of 32 primary breast cancers were determined from serial mammographic views of tumor nucleus shadows in a population of 109 cancers. These cancers were found in a screening population of 10,120 women receiving o... | 445,375 | [
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Correlations in mortality data involving cancers of the colorectum and esophagus. | Massachusetts vital event data for 1969--1972 were used to develop correlations between mortality rates for malignant diseases and other causes of death over the 34 health planning subdivisions of the state. A significant correlation was found between the mortality rates for cancer of the colon and rectum and ischemic ... | 445,380 | [
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Cardiovascular lesions and various tumors found in rats given T-2 toxin, a trichothecene metabolite of Fusarium. | White rats given intragastrically 3alpha-hydroxy-4beta,15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-tricholthec-9-en (T-2 toxin), a trichothecene metabolite of several Fusarium species, developed various acute and chronic, topical and systemic lesions. The rats that survived 12 to 27.5 months after the first of... | 445,416 | [
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Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia. | Significantly decreased uptake and retention of daunorubicin (DAU) and Adriamycin (ADR) have been reported in sublines of P388 leukemia resistant to these anthracyclines. We studied the effects of inhibitors of oxidative phosphorylation on uptake and retention of DAU and ADR in order to characterize the transport proce... | 445,418 | [
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Adequacies and inadequacies in assessing murine toxicity data with antineoplastic agents. | Previous retrospective analyses have suggested a very positive correlation in toxic doses of antineoplastic agents between mice and humans. Additional toxicological information has now been accumulated and reveals a noticeable variability in the existing data base. Nevertheless, it is likely that mouse toxicological st... | 445,419 | [
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Increased survival of rats bearing Morris hepatoma 7800 after induction of hypothyroidism. | The survival of Buffalo rats brearing Morris Hepatoma 7800 was increased significantly (23 to 31%) after induction of hypothyroidism by propylthiouracil (PTU) (0.1% in Purina rat chow) or 131I. The concentration of PTU used was in the optimal range as 0.03% PTU was less effective than 0.1%, while 0.4% PTU appeared to b... | 445,436 | [
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Macromolecular binding and metabolism of the carcinogen 4-chloro-2-methylaniline. | Biochemical investigations relating to the mechanism of action and mechanism of activation have been made for the carcinogen, 4-chloro-2-methylaniline. Radioactivity from 4-chloro-2-[methyl-14C]methylaniline became extensively bound to protein, DNA, and RNA of rat liver, but macromolecules of some of the other tissues ... | 445,453 | [
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-0.301497,
0.06281952,
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0.1185941,
0.1960075,
0.1088893,
0.4065137,
0.1331628,
-0.2090162,
-0.049112... |
Glucosamine 6-phosphate synthase of regenerating rat liver. | When rats were subjected to partial hepatectomy, glucosamine 6-phosphate synthase (EC 5.3.1.19) of the remaining liver underwent alterations both in activity and in molecular form. To study the molecular alterations, glucosamine 6-phosphate synthase was purified from regenerating as well as control liver and was analyz... | 445,482 | [
0.01212746,
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0.1355372,
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0.242221,
0.2862077,
0.2189273,
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... |
Methoxsalen photochemotherapy for mycosis fungoides. | Methoxsalen photochemotherapy (PUVA; psoralen plus ultraviolet light) is effective in the treatment of mycosis fungoides (MF). The mechanism of this beneficial effect is unknown but probably involves covalent photo-binding of methoxsalen molecules to pyrimidine bases in DNA at the cellular level and impaired T-cell fun... | 445,518 | [
0.07490548,
0.08325567,
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0.2626546,
0.2493934,
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0.176549,
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0.569662,
0.20985,
-0.4985231,
-0.09... |
Noninvasively and invasively measured pulsatile haemodynamics with graded arterial stenosis. | Pulsatile haemodynamics associated with graded degrees of experimentally produced stenosis were studied in the canine femoral artery. Invasively determined pulsatile blood flow and noninvasively determined blood velocity with Doppler ultrasound were measured an average of 1.3 and 2.3 cm proximal to the stenosis, respec... | 445,530 | [
-0.115954,
0.3041304,
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0.06586044,
0.1523927,
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0.240529,
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Prostaglandin control of the renal circulation in response to hypoxemia in the fetal lamb in utero. | We studied the effects of 10-minute periods of hypoxemia in unanesthetized fetal lambs in utero instrumented for measurements of arterial pressure and renal and iliac blood flows. Fetal hypoxemia, induced by delivering a hypoxic gas mixture to the ewe, was characterized by a reduction in fetal PaO2 from 20.1 +/- 1.4 to... | 445,701 | [
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0.4509836,
0.04495067,
0.004270358,
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... |
Subxiphoid two-dimensional imaging of the interatrial septum in infants and neonates with congenital heart disease. | The interatrial septum (IAS) was studied by subxiphoid two-dimensional echocardiography (S2DE) in 88 infants under 12 months of age who weighed 1.2-9.1 kg. The IAS was adequately displayed in 87 of 88 patients. The morphology, presence and localization of defects in the IAS were evaluated by S2DE and retrospectively re... | 445,736 | [
-0.317576,
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0.003160966,
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0.08129375,
0.4573684,
0.05828... |
Morphologic development of the pulmonary vascular bed in experimental coarctation of the aorta. | Although electrocardiographic evidence of right ventricular hypertrophy is considered common in newborn infants with coarctation of the aorta, the reason for this finding is not well established. Investigations of the pulmonary vascular bed of these infants have resulted in variable findings, probably due to the differ... | 445,752 | [
-0.03324849,
0.1048869,
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0.2327624,
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0.3499488,
0.1468283,
0.07185584,
0.2998043,
0.09715391,
-0.1042364,... |
Hemodynamic, pulmonary vascular, and myocardial abnormalities secondary to pharmacologic constriction of the fetal ductus arteriosus. A possible mechanism for persistent pulmonary hypertension and transient tricuspid insufficiency in the newborn infant. | The prostaglandin synthetase inhibitor indomethacin was given orally or intravenously to pregnant ewes. This resulted in a significant rise in the fetal pulmonary-to-systemic arterial mean blood pressure difference across the ductus arteriosus, presumably secondary to constriction of the ductus arteriosus. In five expe... | 445,754 | [
-0.2327032,
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0.3238145,
0.1747955,
0.1730135,
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... |
Noninvasive recording of His-Purkinje activity in patients with complete atrioventricular block. Clinical application of an "automated discrimination circuit". | In seven patients with complete atrioventricular (AV) block, His bundle electrograms (HBEs), standard ECG recordings, bipolar esophageal ECGs and highly amplified, filtered, bipolar chest lead ECGs were simultaneously recorded. The filtered chest lead ECG was averaged to determine His-Purkinje activity (HPA). A simplif... | 445,759 | [
-0.02086861,
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0.03604272,
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0.2122259,
0.022513,
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0.5846576,
0.2595514,
-0.01379638... |
Femoral artery pressure measurement during aortography. | Femoral artery pressure (FAP) measurements were carried out to evaluate the hemodynamic significance of aorto-iliac occlusive disease in 150 patients (173 limbs) at the time of transfemoral angiography. Clinical assessment based upon traditional criteria of claudication level, pulse examination, and monoplane angiograp... | 445,768 | [
-0.001139716,
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0.5289112,
0.01436504,
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0.1376991,... |
Preoperative evaluation of subvalular fibrosis in mitral stenosis. A predictor factor in conservative vs replacement surgical therapy. | To assess the degree of mitral subvalvular fibrosis (SVF) in patients with mitral stenosis, left ventriculograms were reviewed, and a mitral subvalvular distance ratio (DR) was determined by dividing the distance from the papillary muscle tips to the closed mitral leaflets in systole by the distance from the aortic val... | 445,777 | [
-0.01243326,
0.05042454,
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0.1500157,
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0.2506703,
0.2976478,
0.0914733,
0.228985,
0.08454117,
-0.140697,
0.107... |
Late hemodynamic evaluation of Hancock Modified orifice aortic bioprosthesis. | Nineteen patients with Hancock Modified Orifice prosthesis (HMO-250), size 19 to 23 mm, were recatheterized 6 to 16 months following aortic valve replacement (AVR). Although hemodynamic characteristics varied widely, HMO-250 compared favorably to the standard model 243 (less than 0.05). Mean peak resting gradient acros... | 445,779 | [
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0.05847824,
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0.04947735,
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0.3267541,
0.2364469,
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0.1113599,
-0.0350965... |
Clinical application of breath analysis for dimethyl sulfide following ingestion of DL-methionine. | After overnight-fasting, the concentration of dimethyl sulfide in expired alveolar gas (alv-DMS) was determined serially following ingestion of 2 g of DL-methionine in normal subjects and patients with liver diseases. Alv-DMS rose to a peak in 30 to 90 min, declined markedly within 3 h, and then decreased gradually. Ha... | 445,853 | [
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0.007231841,
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0.01692718,
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0.2461741,
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0.1487436,
-0.198... |
Two XX male brothers. | Two brothers with XX male syndrome with penoscrotal hypospadias are reported. Chromosomal analysis of cells from the peripheral blood, skin, and testes revealed a normal female karyotype in both subjects. Biopsy of both testes in the brothers showed histological features of normal immature testes and no evidence of ova... | 445,863 | [
0.3718167,
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0.021071,
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0.5220231,
0.2652887,
-0.1638731,
-0.... |
The role of early internal fixation in the management of open fractures. | A series of 101 victims of multiple trauma and open fractures were treated by early open reduction and internal fixation. Some of the fractures included associated vascular injury. Some of the patients had extensive intraarticular fractures. Femur fractures in the elderly were included. All wounds were left open. In 94... | 445,893 | [
-0.1043867,
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0.03754707,
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0.1615826,
0.004155756,
-0.151... |
Plasma chlorpromazine concentrations in children with behavioral disorders and mental illness. | Plasma chlorpromazine (CPZ) levels were studied in children 8 to 15 yr of age who were receiving CPZ for mental disorders. The results showed that children need larger doses of CPZ than adults to attain comparable plasma concentrations. The apparent therapeutic plasma concentration in children (40 to 80 ng/ml) is lower... | 445,954 | [
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0.08497935,
0.1420808,
0.4342321,
-0.1068534,
... |
Kinetics of intravenous amoxicillin in patients on long-term dialysis. | The kinetics of intravenous amoxicillin was studied in 8 patients with creatinine clearances of less than 7 ml/min who were on long-term hemodialysis. Kinetic parameters were determined using a 2-compartment linear model. The serum half-life (t1/2) of amoxicillin in these patients ranged from 7.5 to 21 hr. The t1/2 fel... | 445,959 | [
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0.5989511,
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0.07836077,
0.2301407,
0.100902,
0.1329663,
... |
Effects of radiation therapy on wound healing after mastectomy. | There is increasing use of various forms of reconstructive surgery. This will mean that more patients with previously irradiated tissue will be subjected to these procedures. It is imperative that the surgeon and the radiation therapist collaborate in the management of these patients in order to avoid unneccessary inju... | 445,971 | [
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-0.09350982,
-0.0113865,
-0.01414135,
0.004362... |
Performance by split-brain humans on lateralized vigilance tasks. | Studies are described of the vigilance performance of the cerebral hemispheres of split-brain man. Investigations of visual, auditory and tactual performance are reported for six total commissurotomy patients. The vigilance tasks were lateralized to test the functions of the two hemispheres and make comparison between ... | 446,044 | [
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0.06034151,
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0.2609392,
0.0457897,
-0.07712... |
Preparation of urine for enzyme determinations by gel filtration. | The activities of several enzymes in urine are masked by the presence of interfering substances in native urine. From several methods proposed for the removal of low molecular mass interferences dilution, dialysis, gel filtration, and ultrafiltration have been successfully applied. Gel filtration seems to be of these m... | 446,074 | [
-0.1511899,
0.2342671,
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0.2367588,
0.09940097,
0.01562107,
-0.3398355,
... |
The powerful urinary procoagulant and its relation to renal diseases. | Human urine and urine of various animals contains a powerful procoagulant which converts prothrombin in presence of factors V, VII, X, and phospholipids or thrombocytes into thrombin. In human beings its content of the urine is markedly reduced or totally absent in kidney diseases, but normal in hemophilic patients. On... | 446,080 | [
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0.1200319,
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0.03835111,
0.2802055,
0.1433308,
0.04122519,
0.196... |
Computed tomography of Sturge-Weber disease. | Findings in computed tomography (CT) with or without contrast infusion were analyzed in 8 patients with Sturge-Weber disease. From the extent of calcification in the CT, Sturge-Weber disease can be classified into two types, localized and diffuse. The extent of calcification or cortical atrophy is predictable, if it ca... | 446,195 | [
-0.3821415,
0.1358061,
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0.2080812,
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0.2228566,
0.02826658,
0.1179426,
-0.1196248,... |
Two levels of inferential behavior in young children. | 5- and 6-year-old children made inferences about the spatial locations of animals and people in a series of 3 experiments. The tasks employed manipulable models to represent the spatial relations involved and were made as simple as possible. 2 levels of inferential behavior were found. The first constituted the ability... | 446,197 | [
-0.1645847,
-0.01919749,
-0.3544319,
-0.3242935,
0.08103005,
-0.3977322,
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0.06341904,
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0.1628862,
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0.2254756,
0.4629076,
0.4489807,
0.1955531,
... |
[Peripheral arterial injuries due to fractures and dislocations]. | Using 12 typical cases, which are tabulated, the diagnosis and therapy of combined bone and vascular injuries are demonstrated. Particular emphasis is put on a detailed presurgery diagnosis, if possible angiographic diagnosis. Early surgery, subject to a generous indication, with resection of the injured vascular segme... | 446,222 | [
-0.307467,
-0.02472029,
-0.2069789,
-0.1271188,
0.273077,
-0.3324776,
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0.1140185,
0.1119918,
0.3003302,
0.1202405,
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0.1336837,
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0.4768265,
0.2714762,
0.02773667,
0.1409069,
0.0547... |
[Crohn's proctocolitis with involvement of the esophagus and mouth. Case report]. | A case of esophageal Crohn's disease occurring in a 40-year-old woman with proctocolitis and oral manifestation is reported. A possible connection between Crohn's disease and Behçet's syndrome is discussed. A survey of the literature indicates that comparable lesions occur very rarely. | 446,223 | [
-0.09509972,
-0.2201989,
0.1671576,
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0.121451,
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0.03713789,
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0.2093462,
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0.1904366,
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0.03310928,
0.4253106,
0.1398054,
0.007514594,
... |
Sigmoidoscopic examinations with rigid and flexible fiberoptic sigmoidoscopes in the surgeon's office: a comparative prospective study of effectiveness in 1,012 cases. | The results obtained from 1,012 examinations in an on-going, cooperative study indicate that the overall yield provided by use of the flexible fiberoptic sigmoidoscope is 3.2 times greater than that of examinations with the rigid sigmoidoscope. More than twice (2.4 times) the number of polyps and more than three times ... | 446,248 | [
0.05097541,
0.125135,
-0.094151,
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0.05857526,
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0.1462628,
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0.02232143,
-0.04360309,
0.04044841,
0.3031027,
-0.01544977,
-0.12380... |
[Surgical treatment of left ventricular aneurysm (author's transl)]. | 174 cardiac aneurysms were resected between 1970 and 1977. In 49 patients the remaining contractile segment was revascularised at the same time. The hospital mortality was 10.3%, the late mortality was 14%. The uncorrected cumulative survival rate calculated by the acturial method was 90% at 3 years (84--96), and 80% a... | 446,279 | [
-0.08622888,
0.06672718,
-0.4380381,
-0.03680687,
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0.1329789,
0.1438351,
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0.3600235,
-0.1345145,
0.3006138,
0.6886228,
-0.006265382,
-0.04... |
[The place of autotransfusion with normovolaemic haemodilution in vascular surgery (author's transl)]. | The ever-increasing demand for donor blood, the risks of donor-blood transfusions and economic considerations have made the use of autotransfusion desirable. Among methods for producing autologous blood stores that of obtaining autologous blood with simultaneous normovolaemic haemodilution (using dextran 60; Macrodex 6... | 446,294 | [
-0.2513394,
0.02645658,
-0.3159557,
0.09048004,
0.1568941,
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0.1190507,
0.01150558,
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0.2018018,
0.08058947,
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0.1058477,
0.1782847,
-0.2175061,
0.2472052,
0.6292222,
0.1807681,
0.003174128,
0.... |
[Diagnosis of peripheral arterial occlusive disease: clinical, haemodynamic and metabolic investigation (author's transl)]. | The value of quantitative (venous-occlusion plethysmography), semiquantitative (ultrasound-Doppler method; walking distance; duration of bicycle ergometry) and metabolic (lactate, pyruvate) tests was assessed in 41 patients with arterial occlusive disease of the upper leg type. It was demonstrated that blood pressure m... | 446,295 | [
0.1019465,
-0.1065568,
0.06809841,
0.2191083,
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0.1594998,
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0.03900766,
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0.491708,
0.2217927,
0.1222577,
0.06874664,
0.22... |
Regional differences in response to electrical stimulation within the medial preoptic-suprachiasmatic region on blood luteinizing hormone levels in ovariectomized and ovariectomized, estrogen-primed rats. | The effect of electrical stimulation of the medial preoptic-suprachiasmatic nucleus (MPOA-SCN) region of the forebrain on blood LH levels was studied in ovariectomized, pentobarbital-anesthetized rats. Animals were either not primed with estrogen or previously given 5 micrograms estradiol benzoate (EB)/100 g BW . day f... | 446,364 | [
0.1245754,
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... |
Morbidity and mortality study of shale oil workers in the United States. | The study of the carcinogenic potential of domestic U. S. shale oil has increased significantly in importance because of the present energy problem and resulting research into alternative sources of fuel. With the increased scope of planned oil shale activity on the Colorado Plateau, it is important that an attempt be ... | 446,452 | [
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0.6031892,
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Deficiency of high-affinity anti-beta-D-galactosidase antibodies in selected low immune responder mice. | Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amount... | 446,520 | [
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On the inhibitory effect of 2-amino-4,6-dichloropyrimidine on growth of vaccinia virus. | 2-Amino-4,6-dichloropyrimidine prevents maturation of Vaccinia virus. Proteins synthesized in the presence of the drug are not assembled into virions. | 446,602 | [
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... |
Innervation by W-type retinal ganglion cells of superior colliculus neurons projecting to pulvinar nuclei in cats. | Neurons of the cat superior colliculus (SC) sending their axons to the pulvinar nuclei were identified electrophysiologically as the ones responding antidromically to electrical stimulation of the pulvinar nuclei. They were located in the superficial layers of SC and found to be innervated by axons of W-type ganglion c... | 446,607 | [
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... |
Electrophysiological actions of chlorimipramine on guinea-pig ventricular fibres. | Chlorimipramine (CMI, 1 x 10(-5)M to 7 X 10(-5)M) decreased the amplitude, overshoot and rate of rise of ventricular action potentials and abolished the Ca-mediated action potentials elicited in guinea-pig papillary muscles. These results indicates that CMI inhibits the rise in sodium and calcium conductances during th... | 446,618 | [
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0.04058131,
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Effects of chronic lithium administration on concanavalin A binding to plasma membranes from the corpus striatum of rat brain. | The effects of chronic in vivo lithium administration on mannose-containing components of plasma membranes from rat corpus striatum were examined by a 3H-concanavalin A binding displacement method. No difference on Con A binding was observed between sodium or lithium-treated rats during a 1-month period. | 446,672 | [
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Murine primitive neuroectodermal tumor: nucleolar isolation and RNA polymerase inhibition. | A nucleolar isolation procedure was developed for the murine primitive neuroectodermal tumor originally induced with methylcholanthrene. This procedure utilizes sonication for breakage of the nuclei at a magnesium concentration which disperses the extranucleolar chromatin. The nucleoli retain RNA synthetic activity whi... | 446,675 | [
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A source of error in the fluorometric determination of protein in human placental microsomes. | When protein is assayed in human placental microsomes by the fluorescamine procedure, 25--30% of the observed fluorescence results from labeling of phospholipids. | 446,690 | [
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... |
[Effect of lithium oxybutyrate on the polypeptide and noradrenaline content in the rat hypothalamus]. | It was established that single administration to rats of 200 mg/kg of lithium hydroxybutyrate releases noradrenalin from the terminals of hypothalamus adrenergic fibers and increases output of polypeptides in the neurons of supraoptic and paraventricular nuclei of the hypothalamus. After repeated administration of the ... | 446,697 | [
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0.04553101,
... |
[Action of nonachlazine on thrombocyte aggregation induced by adrenaline]. | Nonachlazine at concentrations 10(-6)--10(-4)M inhibited platelet aggregation in rabbits induced by adrenalin in vitro. The same concentrations of the drug produced an appreciable increase in aggregation reversibility. Intravenous injection of nonachlazine into the rabbit 50 minutes prior to adrenalin protected the pla... | 446,703 | [
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0.1262815,
... |
A new long-acting injectable microcapsule system for the administration of progesterone. | A long-acting injectable microcapsule system for the controlled-release systemic administration of progesterone (P4) is described. The system consists of microcapsules made of the biodegradable polymer, d,l-polylactic acid, which contain crystalline P4. Following injection, P4 is released from the microcapsules by diff... | 446,779 | [
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0.4506758,
0.1737992,
0.0256203... |
[Hemoglobin A1c and diabetes control (author's transl)]. | Hemoglobin A1c (HbA1c) is a minor component of human hemoglobin resulting from a non enzymatic linkage of glucose with the NH2-terminal amino acid of the beta chain of hemoglobin. Under normal conditions, HbA1c represent about 5% of total hemoglobin. The HbA1c blood concentration increases in direct proportion of the d... | 446,835 | [
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0.2939201,
0.2244244,
-0.04161834,
-0.0203... |
Spontaneous tumors in nude mice: effect of the viable yellow gene. | The incidence and type of spontaneous tumors in athymic nude (nu/nu) mice (partially inbred in CBA/H background) which were also carrying the viable yellow gene (Avy, derived from C57BL/6JAvy mice), were comparable to those observed in the phenotypically normal nu/+ and +/+ control crosses carrying the Avy gene. The Av... | 446,837 | [
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0.1461384,
0.3065735,
0.365688,
-0.212456... |
Competitive binding studies with glucocorticoid receptors from rat-thymus cells: differential temperature-dependence of steroid binding. | Competitive steroid-binding studies were performed with intact rat thymus cells and with cytosol preparations at different temperatures using [1,2-3H]dexamethasone as the labelled ligand. Steroids lacking a 17 alpha-hydroxyl group, such as corticosterone, were better able to compete with [1,2-3H]dexamethasone for bindi... | 446,878 | [
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0.08342118,
0.3915183,
0.3025733,
0.2203731,
-0.04769728... |
Thin muscle capillary basement membranes in myotonic dystrophy. | Muscle capillary basement membrane width (MCBMW) was measured in 18 myotonic dystrophy patients and compared with that in age- and sex-matched normal and diabetic subjects. The MCBMW in myotonic dystrophy patients (773 +/- 258 A) was significantly thinner than in normal subjects (925 +/- 181 A, P less than 0.05) or in... | 446,922 | [
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... |
A newly improved sliding tube for colonoscopy for keeping the sigmoid colon in a straight condition. | Although a sliding tube made of plastics is very effective to keep the sigmoid colon in a straight position, there is some difficulty in handling the colonoscope, being restricted by the length of the scope. For the purpose of covering the demerits of the conventional sliding tube, a new slit sliding tube which is made... | 446,981 | [
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0.2198077,
0.04976447,
-0.03601455,... |
Assessment of the clinical usefulness of serum ribonuclease assays: an indicator for the detection of pancreatic cancer. | To evaluate diagnostic usefulness for pancreatic cancer, serum ribonuclease (RNase) level was determined in three groups of subjects; 1) normal volunteers as control, 2) patients with histologically determined pancreatic cancer, and 3) patients with miscellaneous diseases other than pancreatic cancer. A small increase ... | 446,987 | [
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0.09471757,
-0.1271931,... |
The role of radiocopper in the diagnosis of Wilson's disease. | In patients with normal serum concentrations of ceruloplasmin, measurement of the incorporation of radiocopper into this protein can aid in the clinically important differentiation of patients with hepatic illnesses that mimic Wilson's disease from patients with this disorder. | 447,011 | [
-0.2464514,
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Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis. | The effect of moderate cirrhosis on the bioavailability and systemic clearance of three model analgesic compounds (pethidine, pentazocine, and salicylamide) with substantial first-pass metabolism was examined in 8 cirrhotic subjects and 4 agematched healthy controls. There was a 46% decrease in the clearance of pentazo... | 447,033 | [
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... |
Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats. | The correlation between acid secretion and mucosal blood flow in the rat stomach during stress loading was determined to provide clues to the etiology of the gastric ulceration which thus occurs. The gastric acid output was increased remarkably by water-immersion stress at 23 degrees C, and this increase lasted while t... | 447,044 | [
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Current concepts in managing TIAs and stroke. | No permanent neurologic deficit results from a transient ischemic attack, but patients with these episodes are at risk of stroke. Successful treatment depends on identifying the source of the problem--the heart, blood, or vessel wall. However, anticoagulants and antiplatelet agglutinating agents will reduce only the in... | 447,070 | [
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... |
Transnasal bile duct catheterisation after endoscopic sphincterotomy: method for biliary drainage, perfusion, and sequential cholangiography. | We describe a method for leaving a catheter in the common bile duct for several days, even weeks, after endoscopic sphincterotomy. This provides reliable biliary drainage, and permits perfusion of the duct with simple fluids or solvents. It reduces the need for instrumental stone extraction and for repeated endoscopy a... | 447,108 | [
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0.143824... |
On the problem of variable numbers of hosts in the life-cycles of helminths. | The authors analyze the phenomena underlying the variation of host numbers in the life-cycle of several helminth species. Variation of host number in the cycle is effected by alternative shortening of the cycle (with this the cycle turns out either without or with a polyvalent obligatory host or, in rarer cases, withou... | 447,125 | [
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0.1737482,
0.01770435... |
Mammals as source of ectoparasites in towns. | Four ecological groups of mammal ectoparasites are recognized in urban environment and their medical importance is briefly mentioned. | 447,131 | [
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0.1082016,
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Rib-cage injuries indicating the direction and strength of impact. | The hardness and loading capacity of hundreds of rib pairs have been tested and compared with the results of about 200 tests concerning belt-protected human cadavers. Rib fractures exhibit patterns that indicate the direction and strength of impact. Differences are seen between static and dynamic loading. Deformation o... | 447,141 | [
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Red cell PGM1 (phosphoglucomutase) phenotyping by isoelectric focussing and starch gel electrophoresis in cases of disputed paternity in the United Kingdom. An evaluation of the results obtained in 95 cases. | Using two techniques for red cell PGM1 (phosphoglucomutase) phenotyping, namely starch gel electrophoresis and isoelectric focussing, a parallel study has been carried out in 95 paternity cases. The results again confirm the genetic basis for the extended polymorphism revealed by isoelectric focussing. Fifteen men were... | 447,151 | [
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0.1145436... |
[Intestinal gas gangrene originating from the gallbladder: diagnosis, therapy, report of 2 cases]. | The problems of diagnosis and therapy of gas gangrene of the gastrointestinal tube and the gallbladder are discussed. 2 cases of gas edema of the gallbladder due to clostridium perfringens are reported. One of the patients survived. The early diagnosis of gas gangrene is important because of the extraordinary way of in... | 447,171 | [
-0.2282842,
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0.004700924,
0.08246405,
0.01334174,
0.04958081,
-0.2246841,
-0.09789073,
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0.02384773,
0.3815888,
0.06733467,
-0.1763674,
0.1704925,
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-0.3001092,
0.258694,
0.1255981,
0.1515977,
0.433516,
0.07897835,
0.07764815,
... |
Angiocardiography in the pre-operative evaluation of patients with univentricular hearts. | Diagnosis of the univentricular heart and recognition of its most important variations depends on the establishment of atrial situs, the demonstration of the type and mode of the atrio-ventricular connexion, the identification of the presence or absence of a rudimentary chamber, the establishment of its morphology, tog... | 447,183 | [
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... |
Echocardiography of atrioventricular valves in patients with univentricular heart. | M-Mode echocardiography in patients with univentricular heart allows the number and relations of the AV valves to be established. The absence of a posterior septum can be documented with some certainty and in many cases a stradding AV valve suspected. In addition, reduced amplitude of diastolic closure velocity is very... | 447,184 | [
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Surgical septation of univentricular heart with outlet chamber. | From April 1973 through March 1978, 34 patients with univentricular heart and outlet chamber underwent repair by septation of the ventricle. Three had normally related great arteries in which the pulmonary artery arose from the outlet chamber. Six patients had an anterior aorta arising from an anterior or right-sided o... | 447,190 | [
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Postnatal maturation patterns of serum corticosterone and growth hormone in rats: effect of chronic thyroxine administration. | The effects of chronic neonatal hyperthyroidism in rats on the ontogenic pattern of serum corticosterone and growth hormone (GH) were studied. Thyroxine (T4) treated and saline injected rat pups were sacrificed under basal and stress conditions. In comparison to saline control animals, daily T4 administration (0.4 micr... | 447,204 | [
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0.05901451,
0.1013849,
0.2515648,
0.005710545,
-0.1413417... |
Plasma concentration of antidiuretic hormone in patients with chronic renal insufficiency on maintenance dialysis. | Radioimmunoassay of plasma arginine-vasopressin (AVP) in regularly dialyzed patients with chronic renal insufficiency revealed a parallel increase of AVP and plasma osmolality (POsm) before dialysis (4.16 +/- 0.36 pg/ml and 312.6 +/- 1.80 mOsm/1) and their parallel declin to the normal range (1.93 +/- 0.27 pg/ml and 29... | 447,206 | [
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... |
Using the resources of AA in treating alcoholics in a general hospital. | At Cleveland Metropolitan General Hospital a small number of staff and a large number of volunteers from Alcoholics Anonymous have collaborated to meet the treatment needs of the community's alcoholics. Recovered alcoholics serve as volunteers staffing a friendship room, located close to the emergency room and open wee... | 447,233 | [
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-0.06596887,
-0.0663523... |
Family, heal thyself. | Although the technique is still not widespread, family therapy, in which the entire family unit is part of the therapeutic process, promises to speed results. | 447,252 | [
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0.2076881,
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0.1157048,
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0.1684319,
0.2747551,
0.1093953,
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Britain's NHS: problems we all may face. | Is Britain's nationalized health care system experiencing and coping with pressures that other nation's health care systems will have to face in the future? | 447,260 | [
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0.04250839,
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New tax laws require slight shifts in hospitals' funding strategies. | Recent tax laws that affect hospitals' deferred compensation plans, employment taxes, annuities, foundation grants, unrelated business income, and gifts of appreciated property will not seriously affect charitable giving to hospitals. | 447,274 | [
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... |
The PR war isn't the real war. | Although hospitals are losing the competition for headlines and television news time, public opinion can make itself evident with astonishing force when hospitals are threatened. | 447,291 | [
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0.260108,
0.08543146,
-0.0297979,
... |
Catholic health care institutions and social justice. | What implications for the health care apostolate lie in the programs and plans of the National Conference of Catholic Bishops and the United States Catholic Conference? This question is explored through looking at the relationship of the health care ministry to NCCB and USCC priorities--social justice, family life, par... | 447,299 | [
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Adjuvant properties of retinol on IgE production in mice. | Mice treated with varying doses of retinol in Tween 80 showed no primary IgE response to ovalbumin in saline; however, reimmunization with ovalbumin in saline produced high IgE titers. Retinol-treated mice immunized with ovalbumin absorbed to Al (OH)3 also showed no primary IgE response, but high secondary responses. S... | 447,406 | [
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Humoral mediator of antigenic competition demonstrated in vivo. | To determine if a soluble mediator of antigenic competition could be demonstrated in vivo, various groups of mice received implants of intraperitoneal Millipore diffusion chambers containing normal spleen cells and sheep erythrocytes (SRC). Priming and boosting the chamber hosts so that a vigorous secondary immune resp... | 447,413 | [
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... |
Pain as a joint function of alcohol intake and customary reasons for drinking. | Nonalcoholics who, on a problem drinking inventory, responded "yes" to items reflecting a psychological dependence on alcohol, tended after alcohol ingestion to report a decrease in pain experienced in a cold pressor test. Conversely, those whose responses indicated no psychological dependence on alcohol tended to repo... | 447,427 | [
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The relationship between female criminality and drug use. | A 2-year study of four groups of women (N = 268)--addicts, prostitute-addicts, prostitutes, and female offenders--reveals that the link between female criminal activity and female drug involvement is significant. All four groups report "drug costs" as a major percentage of their monthly expenses. Prostitutes and female... | 447,431 | [
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The pharmacokinetics of dapsone and acetylated dapsone in serum and saliva. | The concentrations of dapsone (DDS) and its acetylated derivatives (MADDS and DADDS) were determined in the serum and saliva after one oral dose of dapsone until 72 hr. The peak serum concentrations of DDS and MADDS were reached, on average, at 3.8--4.3 hr after the dosage. The amounts of DADDS were negligible. The eli... | 447,435 | [
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0.2053842,
0.1093781,
0.2457413,
0.2280447,
0.03223198,
-0.263532,
-0.196195... |
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