title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Long term variations in trypanosome infection rates in highly infected tsetse flies on a cattle route in south-western Nigeria. | One thousand, nine hundred and ninety-seven male and 1988 female Glossina morsitans submorsitans were dissected at Ogbomosho, on a trade cattle route in south-western Nigeria, from June 1970 to August 1973. Of male flies, 1307 (65-45%) were infected by Trypanosoma vivax trypanosomes, 66 (3-31%) by the subgenus Nannomon... | 849,015 | [
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Correction of anomalous subdiaphragmatic inferior vena caval drainage of the right pulmonary veins (scimitar syndrome). | Correction of anomalous infradiaphragmatic inferior vena caval drainage of the right pulmonary veins can be repaired under conventional cardiopulmonary bypass by placing a circumferential tape below the diaphragm between the hepatic veins and the scimitar vein entrance. During repair, creation of an atrial septal defec... | 849,037 | [
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Hemolysis due to chemical contamination of clinical perfusion apparatus. | A chemical contaminant found on the interior surface of the extracorporeal apparatus manufactured by the William Harvey Corporation was believed to have caused severe hematuria in 2 children. The biological activity of the contaminant was tested by mixing 50 ml of whole blood in contaminated cardiotomies; after 5 minut... | 849,052 | [
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Further studies on the action of ultraviolet light on vascular smooth muscle: effect of partial irreversible receptor blockade. | Isolated rabbit thoracic aorta which is pharmacologically contracted will relax when exposed to ultraviolet light. The relaxation is reversible in that the tension is restored when the light source is removed. The purpose of this investigation was to study further the phenomenon of photorelaxation on vascular smooth mu... | 849,060 | [
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The action of serotonin on basal gastric secretion in the conscious rat after intraventricular and intraperitoneal administration. | In unanesthetized rats with chronic gastric fistulas the effect of various doses of 5-HT and atropine given intraperitoneally (i.p.) or into the lateral cerebral ventricle (i.c.) on basal gastric secretion was investigated. 5-HT given i.e. reduced HCl secretion more strongly than by the i.p. route. Atropine reduced gas... | 849,062 | [
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Interactions of narcotics and their antagonists with human serum esterase. VI: The behavior of 14-hydroxylated morphine derivatives. | Study of the interaction of 14-hydroxylated morphines and morphinans with human serum esterase revealed behavior similar to that of other morphine derivates as shown by similar acceleratory efficacies and affinity constants. However, 14-hydroxydihydro-6-morphinones showed anomalously low apparent affinities and anomalo... | 849,070 | [
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Interaction of quinidine and propranolol in experimental cardiac arrhythmias in the dog. | Quinidine, propranolol and their combination were studied in atrial fibrillation induced by the topical application of acetylcholine or aconitine, injury-stimulation-induced atrial flutter and ventricular ectopic tachycardia produced by coronary occlusion in the dog. The effect of combination of quinidine and propranol... | 849,075 | [
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Neurochemical properties of 3,3-dimethyl-1-[3-(methylamino) propyl]-1-phenylindan HCl (LU 3-049) and selected tricyclic antidepressants. | Lu 3-049 was compared to certain antidepressants on biogenic amine metabolism. Like desipramine, Lu 3-049 was found to possess potent and selective inhibitory effects on norepinephrine uptake. In rat brain and mouse heart, both agents were found to be considerably more potent than imipramine and chlorimipramine. Unlike... | 849,078 | [
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The impact of community mental health centers on the utilization of services. | The impact of community mental health centers on the utilization of psychiatric services in Monroe County, New York, was evaluated by means of data from the Monroe County Psychiatric Case Register. The catchment areas that received centers served as their own controls. In addition, yearly utilization rates were compare... | 849,109 | [
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Infantile Erb's palsy (Smellie's palsy). | Our experience with 32 infants seen with Erb's palsy, of whom 11 were followed as long as 18 years, suggests two management axioms. First, it is probably harmful to the infant to use airplane splints. Seocnd, passive stretching of the tight scapulohumeral adductors and passive normal range of motion exercises to should... | 849,132 | [
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Sexual arousal in women: a comparison of cognitive and physiological responses by continuous measurement. | Six sexually normal women were exposed to a wide variety of erotic video tapes while vaginal, groin, and breast vasocongestion measures were tkane. The women indicated their level of sexual arousal while viewing the tapes by positioning a lever device along a calibrated scale. The results indicated highly significant p... | 849,137 | [
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Renal artery dissections. | Renal artery dissections encountered in 15 patients, aged 3 to 75 years, were categorized as to pathogenesis (blunt abdominal trauma, catheter injury, and spontaneous). Blunt traumatic dissections (seven patients) were characterized by hypertension, gross hematuria, and pain. Catheter-induced dissections (four patients... | 849,148 | [
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Family history in primary open-angle glaucoma. | A family history of glaucoma was found in 50% of patients with primary open-angle glaucoma (POAG) and 43% of patients with ocular hypertension (OH). Positive family history was twice as prevalent in those with OH and either HLA-B7 or B12 antigens than in OH with neither antigen (P less than .01). Although POAG occurred... | 849,183 | [
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An arteriotonograph. A new instrument for measuring the pressure in the ophthalmic artery. | A new piece of equipment was developed that records the intraocular pressure at the time of biomicroscopically observed collapse of the central retinal artery on the optic disc. A special contact lens with a properly adjusted pressure-sensitive probe allows exact observation of the optic disc and manual compression of ... | 849,193 | [
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Acoustic tumor detection with brain stem electric response audiometry. | Tumors that press on the audiotry nerve can cause a latency increase that is detectable from the scalp by electric response audiometry (BERA). The response delay is best seen by comparing the Jewett wave V, or P5, latencies for the two ears. This interaural latency difference is normally less than 0.2 msec, but was 0.4... | 849,194 | [
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Surgical treatment of squamous cell carcinoma of the oral tongue: factors influencing survival. | One hundred fifty patients with squamous cell carcinoma of the oral tongue (anterior two thirds) treated initially by surgery alone were analyzed and factors influencing survival were evaluated. Thirteen patients who died without evidence of disease in less than five years were excluded, leaving 137 determinate cases f... | 849,198 | [
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Ventilation in secretory otitis media: effects on middle ear volume and eustachian tube function. | Conductive hearing loss due to secretory otitis media is the commonest form of hearing loss in children. Eustachian tube dysfunction is often implicated as the most important factor in the origin and course of the disease. It is well known that myringotomy, aspiration of fluid from within the middle ear, and ventilatio... | 849,200 | [
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The effects of sedation on the impedance test battery. | Fifteen adults, hospitalized for fiberoptic endoscopy studies, were tested under two conditions using impedance audiometry. The first series of tests was conducted prior to the fiberoptic studies and sedation; the second immediately following examination, approximately 20 minutes after sedation with diazepam (Valium) a... | 849,202 | [
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Bone conduction speech discrimination: an indication of cochlear function in the immediate postoperative period. | We illustrate that the apparent sensorineural audiometric changes immediately following stapedectomy are not indicative of a true sensorineural type hearing loss. The cochlear changes evident by postoperative pure-tone and air conduction speech discrimination audiometric tests are not reflective of the true cochlear re... | 849,203 | [
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Paralysis of calves by the tick, Ixodes Holocyclus. | Adult female Ixodes holocyclus were collected from the field at Fig Tree Pocket, a Brisbane suburb, at Tamborine Mountain, Queensland and at Lismore, New South Wales, in November 1974. Females were also reared from engorged nymphs collected off bandicoots from Tamborine Mountain July 1974 and 1975. In November 1974 une... | 849,217 | [
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The phosphorylation of an acidic protein of the large ribosomal subunit of Krebs II ascites cells. | The ribosomes of Krebs II ascites cells contain an acidic protein, apparently analogous to proteins L7/12 of Escherichia coli. When ascites cells were incubated with [32P]Pi, this protein became labelled, indicating that it is a phosphoprotein. | 849,276 | [
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The effects of inhibition of gluconeogenesis in suckling newborn rats. | Inhibition of gluconeogenesis with 3-mercaptopicolinate in suckling newborn rats caused a fall in blood [glucose], but no change in their high plasma [free fatty acid] and blood [ketone bodies]. Active gluconeogenesis seems to be more important than sparing of glucose by high concentrations of fat-derived substrates fo... | 849,278 | [
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Labelling studies in vivo on the metabolism of the acyl and glycerol moieties of the glycerolipids in the developing maize leaf. | 1. When [2-3H]glycerol was supplied to developing maize-leaf laminae, label entered 3-sn-phosphatidycholine at a linear rate essentially from zero time, whereas other lipids were labelled at accelerating rates. On transfer of laminae from [3H]glycerol to unlabelled glycerol, radioactivity was rapidly lost from 3-sn-pho... | 849,284 | [
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The university rheumatic disease clinic: provider and patient receptions of cost. | A medical school based rheumatic disease clinic provides patient services and educational activities and conducts clinical research. The patient population and routes of access to one such clinic are described, and the effect of direct and indirect costs influencing patient compliance are analyzed. It was found that th... | 849,370 | [
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Enhanced synthesis and accumulation of collagen in cholesterol-aggravated pigeon atherosclerosis. | Atherosclerotic segments of pigeon aorta synthesized collagen at four times the rate found in normal aorta (Athero = 2071 +/- 1339 ng/g/h; Control = 497 +/- 192 ng/g/h; P less than 0.025). Similar results were obtained when synthesis was expressed per mg DNA. Elevation in collagen synthesis was relatively specific, col... | 849,379 | [
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Endomyocardial fibrosis and eosinophilia. | Absolute eosinophil counts were assessed in 15 African patients with proven endomyocardial fibrosis. Though the mean eosinophil count in patients with endomyocardial fibrosis was higher compared with the normals reported from Kampala (1-13 vs 0.72X10(9)/1), the absolute range was comparable. A high percentage of patien... | 849,383 | [
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A study of systolic time intervals during uninterrupted exercise. | A method has been developed for obtaining measurements of the systolic time intervals during uninterrupted graded exercise in the upright position on a bicycle ergometer. The method has been applied to 112 subjects divided into 4 groups: two of normal subjects below and above the age of 40, respectively (mean ages 30 a... | 849,384 | [
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Changes in systolic time intervals during treatment of diabetes mellitus. | The cardiovascular response to the control of diabetes by sulphonylurea drugs has been investigated using systolic time intervals in a group of 19 diabetics. Before treatment a significantly greater heart rate and shortening of QS2 interval and left ventricular ejection time index were encountered among the more hyperg... | 849,385 | [
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0.07064646,
0.06872... |
Crystallographic studies of protein denaturation and renaturation. 2. Sodium dodecyl sulfate induced structural changes in triclinic lysozyme. | Cross-linked triclinic lysozyme was denatured with sodium dodecyl sulfate. Removal of the denaturant resulted in a refolding of the protein to a conformation similar to but not identical with the native one. Three-dimensional x-ray diffraction data out to 3.2-A resolution were collected for two states in the refolding ... | 849,424 | [
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Excision of 7-bromomethylbenz[a]anthracene--DNA adducts in replicating mammalian cells. | The excision of 7-bromomethylbenz[a]anthracene--DNA adducts was studied in two cell lines (HeLa S-3 and Chinese hamster V-79379A). In both cell lines, carcinogen-modified adenine residues were excised more readily than the modified guanine residues and the percentage of the total products excised decreased after treatm... | 849,427 | [
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The kinetic behavior of P-700 during the induction of photosynthesis in algae. | The kinetics of P-700 were examined spectrophotometrically during the induction of photosynthesis in algae. A pronounced oscillation was observed in the redox level of P-700 upon illumination of dark-adapted cells. The dark adaptation required approximately 1 min. The oscillation may be described as an initial rapid ox... | 849,435 | [
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Staining of proteins after isoelectric focusing in gels by new procedures. | Four procedures are described for staining of protein bands after isoelectric focusing in polyacrylamide gels. In one procedure, Coomassie Brilliant Blue R 250 is used whereas in the others the G 250 form is used in an aqueous solution of perchloric acid. By using isoelectric focusing and the new staining procedures it... | 849,455 | [
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[Analysis of spatial frequency characteristics of complex receptive fields]. | The difference fB2-fB1=deltaf and ratio fB2/fB1=R of the bandwidth boundary frequencies fB1, fB2 of spatial frequency characteristic of complex receptive field depends on the size of RF and spatial structure of excitatory and inhibitory zones. deltaf and r are independent of the weighting functions of excitatory and in... | 849,490 | [
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Medical imaging by NMR. | Application of the new nuclear magnetic resonance (NMR) method of fast scan proton imaging is described. Cross sectional proton scans of a human finger in vivo are measured and reveal considerable anatomical detail, particularly of the soft tissue regions. Imaging of tumour tissue is also briefly discussed. | 849,520 | [
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Symposium on diarrhea. 5. Postoperative diarrhea. | Under normal circumstances many physiologic mechanisms prevent diarrhea. The most important are the normal processes of gastric emptying, digestion and absorption, the functioning of the ileocecal valve and elimination of bacteria from the small bowel. A surgical procedure may disrupt any of these mechanisms or may unm... | 849,556 | [
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Symposium on diarrhea. 6. Infectious diarrhea. | Diarrhea may be primarily infectious in origin. Causes can be conveniently classified according to the etiologic agent, which may be viral, chlamydial, bacterial, protozoal, helminthic or fungal. The most common type of infectious diarrhea in Canada is viral. Bacterial infection, particularly staphylococcal and salmone... | 849,557 | [
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Excretion of pyrrolic metabolites in the bile of rats given the pyrrolizidine alkaloid retrorsine or the bis-N-ethylcarbamate of synthanecine A. | (1) A comparison has been made in male rats between the biliary excretion of pyrrolic metabolites from the pyrrolizidine alkaloid retrorsine and a synthetic analogue 1-methyl-2,3-pyrroline-bis-N-ethyl-carbamate (Synthanecine A bis-N-ethylcarbamate). (2) When bile duct-cannulated rats were given retrorsine (40 mg/kg) an... | 849,622 | [
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Cryodynamic hand angiography in the diagnosis and management of Raynaud's syndrome. | Cryodynamic hand angiography (CHA) with angiograms done before, just after, and during rewarming following hand immersion in ice water was performed in 39 patients with Raynaud's syndrome and eight volunteers without it. The normal response to cold stimulus was angiographically evident as mild, transient digital arteri... | 849,637 | [
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Network of immune-neuroendocrine interactions. | In order to bring the self-regulated immune system into conformity with other body systems its functioning within the context of an immune-neuroendocrine network is proposed. This hypothesis is based on the existence of afferent--efferent pathways between immune and neuroendocrine structures. Major endocrine responses ... | 849,642 | [
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C4 in glomerular lesions of NZB/NZW mice. | Antisera to human C4 can discriminate circulating Ss protein (C4) levels in mice. Since there has been no information on early complement components (C1, C4, C2) in the renal lesions of B/W mice, we applied the indirect immunofluorescence technique to post-mortem sections of kidney from B/W female mice with advanced re... | 849,653 | [
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The localization of rectosigmoidal tumors or biopsy sites by methylene blue marking. | Methylene blue marking of small tumors, biopsy sites, or any tumor in an obese patient is a simple, safe and direct method for accurate identification and resection of rectosigmoidal lesions. | 849,693 | [
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Spontaneous ischemic colitis. | Eighteen cases of spontaneous ischemic colitis are reviewed. The diagnosis was established according to the following criteria: 1) clinical background, 2) clinical characteristics, 3) morphologic characteristics, and 4) clinical and morphologic course. The last three constituted the diagnostic criteria. The cases were ... | 849,694 | [
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Effect of bisacodyl on the structure and function of rodent and human intestine. | The effect of bisacodyl on intestinal structure and function was investigated. Net water transport was measured under steady state conditions in vivo during single pass infusions of rodent and of human intestinal segments. Each segment served as its own control. Bisacodyl inhibited water absorption in rat jejunum, ileu... | 849,815 | [
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Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach. | A pharmacological analysis has been made of the effects of metoclopramide on the contractile activity of isolated longitudinal muscle strips prepared from the guinea pig stomach. Metoclopramide produced up to 3-fold increases in the amplitude of the spontaneous contractions exhibited by such a preparation. This phenome... | 849,817 | [
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0.02512495... |
[Epididymitis and fertility. Treatment results in acute unspecific epididymitis]. | Spermiograms of 46 patients were examined 8 days, 4 weeks, 3 months, 6 months and 1 year after acute unilateral non-specific epididymitis. The treatment consisted in 24 cases besides antibiotic treatment with doxycycline in local infiltrations of the spermatic cord with 1% Scandicain solution. Primarily there was found... | 849,851 | [
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Effect of cycloheximide on the synthesis and processing of 5S RNA in HeLa cells. | The synthesis and incorporation into ribosomes of 5S RNA were investigated under conditions of protein synthesis inhibition by cycloheximide. Within 1 h after addition of cycloheximide to the culture medium, the synthesis of 5S RNA in HeLa cells, as measured by the pulse labeling of total 5S RNA, was inhibited by 25-30... | 849,923 | [
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5-O-beta-D-Galactofuranosyl-containing exocellular glycopeptide of Penicillium charlesii. Incorporation of mannose from GPD-D-mannose into glycopeptide. | Three-day-old Penicillium charlesii mycelia were broken with Al2O3 in a buffered system and the membranes were separated on a linear gradient of sucrose concentrations. The most active guanosine 5'-(alpha-D-mannopyranosyl pyrophosphate):glycopeptide mannopyranosyltransferase (GPD-D-mannose mannosyltransferase) was foun... | 849,928 | [
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Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose. | Calf pancreas microsomes incorporated radioactively labeled D-glucose from UDP-D-glucose into products extracted with chloroform/methanol (2:1, v/v), chloroform/methanol/water (10:102.5, v/v), and into the residual precipitate, with a pH optimum in Tris/maleate buffer of about 5.3. The chloroform/methanol extract conta... | 849,929 | [
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Preparation and properties of immobilized rubredoxin. | Rubredoxin, one of the three protein components of the epoxidation/hydroxylation system of Pseudomonas oleovorans was immobilized by attachment to CNBr-activated agarose (Sepharose 4B). Since this represents the first reported example of the preparation of a water-insoluble derivative of an enzyme of this type, the ele... | 849,934 | [
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Biosynthesis of lipid-linked oligosaccharides in cotton fibers. Stimulation by lipids from pig liver. | An acidic lipid fraction isolated from pig liver (Forsee, W. T. & Elbein, A.D. (1976) Proc. Natl. Acad. Sci. U.S.A. 73, 2574-2578) stimulated the incorporation of mannose from GDP-[14C]mannose into lipid-linked oligosaccharides using a particulate enzyme fraction from maturing cotton bolls. This lipid fraction did ... | 849,936 | [
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Flexible (silicone) implant arthroplasty of the metacarpophalangeal joint of the thumb. | Forty-four thumbs in thirty-four patients with rheumatoid arthritis were treated with a flexible implant arthroplasty of the metacarpophalangeal joint. After follow-ups ranging from two to six and a half years the results were rated good to excellent in forty-two thumbs since they were not painful, had an increased arc... | 849,948 | [
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[Reflux into the pancreatic duct during peroperative biliary radiomanometry. Report of 200 cases (author's transl)]. | The authors have observed 200 cases of reflux into the pancreatic duct out of 2,500 biliary operations with radiomanometry. Out of the 200 cases, 109 were functional, i.e. due to a common duct with or without an ampoule of Vater, or due to duodenal stockage whether there was a common duct or not. They had no therapeuti... | 849,964 | [
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The metabolic response to moderate exercise in diabetic man receiving intravenous and subcutaneous insulin. | The responses to moderate exercise of circulating energy fuels and endocrine pancreatic hormones were examined in insulin-dependent diabetics receiving insulin either sc or by continuous iv infusion. Eight subjects received one-third of their usual daily insulin doses sc in the thigh 1 h prior to exercise. Seven subjec... | 849,981 | [
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The effects of temperature and plasma cortisol on distribution of aldosterone between plasma and red blood cells: influence on metabolic clearance rate and on hepatic and renal extraction of aldosterone. | Aldosterone enters red blood cells (RBC) to a greater extent at 37 C than at lower temperatures. The ratio of 3H-aldosterone concentration in RBC to that in plasma increases from 0.2 at 4 C to 0.7 at 37 C when cortisol concentration is low. Increasing plasma cortisol increases the RBC/plasma aldosterone ratio. When pla... | 849,984 | [
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... |
Relationship of siblings to the elderly person's feelings and concerns. | This study investigated the feelings and concerns of 64 elderly persons, as revealed by a projective instrument, in relation to number of sex of siblings. Partilal correlations, with effects of age, education, and occupation removed, were computed separately for each sex. The number and proportion of female siblings we... | 850,060 | [
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0.01587725,... |
Isolation and enumeration of peripheral blood monocytes. | Monocytes were isolated by counterflow contrifugation from human peripheral mononuclear cells obtained from whole blood by the Ficoll-Hypaque technique. Examination of volume spectra of the monocytes showed a bimodal distribution with peaks at 330 and 370 micron3. The upper peak contained 61.4 +/- 3.3% of the total mon... | 850,069 | [
0.06830976,
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0.2522073,
0.2900353,
0... |
Experimental infections with anaerobic bacteria in mice. | Experimental anaerobic infections in mice are reviewed with a description of a model of pure Bacteroides fragilis infection. In this experimental situation, B. fragilis produces large subcutaneous abscesses in the groins of mice that can be diagnosed without autopsy. This infection was treated effectively with clindamy... | 850,086 | [
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0.1063591,
0.3479652,
0.07432817,
0.06336515,
-0.0004483... |
Bacteremia due to Bacteroidacceae: a review of 92 cases. | The clinical courses of 92 patients who had bacteremia due to Bacteroidaceae were reviewed. The overall mortality rate was 21% (19 patients). There was no significant difference between mortality rates when patients were grouped by anticipated clinical course of underlying disease (nonfatal, ultimately fatal, and rapid... | 850,094 | [
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0.09295166,
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0.4749723,
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... |
Extramedullary plasmacytoma of the head and neck, parotid and submandibular salivary glands. | Twenty-two cases of extramedullary plasmacytomas (EMP) were diagnosed in the Birmingham region during 1962-1973. Five cases of EMP of the head and neck are discussed, including cases involving the parotid and submandibular salivary glands. Comparative data on incidence, age, sex, and survival is presented. A multidisci... | 850,104 | [
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0.3558767,
0.1298807,
0.1071129,
-0.0... |
Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat. | Rat striatal slices (two) were superfused continuously with L-3,5-3H tyrosine and 3H-dopamine (3H-DA) release was estimated in serial fractions of superfusates. The spontaneous release of 3H-DA was reduced by about 50% when slices were superfused with a calcium-free medium containing ethylene glycol bis (beta-aminoethy... | 850,127 | [
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0.4161431,
0.1895349,
0.1096949,
... |
Influence of prostaglandin precursors and synthesis inhibitors in vascular bed perfused without a pump. | The present investigation was coducted to examine the role of endogenous prostaglandin (PG) on blood flow and arenergic responses in the paw vasculature perfused without a pump. The PG precursors, arachidonic acid and dihomo-gamma-linolenic acid, given i.a. caused only small increments in paw blood flow which were much... | 850,130 | [
-0.04160833,
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0.490587,
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0.03993601,
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Effects of diazepam on the biliary excretion of diphenylhydantoin in the rat. | Studies were performed to examine the effects of diazepam (DZP) on the biliary excretion of diphenylhydantoin (DPH, phenytoin) in the rat. One-hour pretreatment with DZP (150 mg/kg i.p. or 10 mg/kg i.v.) markedly suppressed the rates as well as the cumulative amounts of radioactivity excreted in bile after administrati... | 850,136 | [
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0.218774,
0.0732048,
-0.... |
Effect of lidocaine and methyl lidocaine on cardiac conduction. | The effects of lidocaine and methyl lidocaine on cardiac conduction were studied using His bundle recordings from isolated blood perfused dog hearts. The input and output characteristic of the atrioventricular (AV) node can be described as consisting of three components, namely, minimal conduction time, fatigue, and th... | 850,138 | [
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0.2501656,
0.2811046,
0.2259485,
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... |
Study of the sites and mechanisms of action of bumetanide in man. | Acute clearance studies were performed in normal subjects to establish the site(s) and mechanism of action of the new diuretic agent, bumetanide (3-n-butylamino-4-phenoxy-5-sulfamylbenzoic acid), in the human kidney. When the drug was administered during water diuresis, solute-free water formation was unchanged associa... | 850,144 | [
-0.3951494,
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0.06903377,
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0.2107652,
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0.1790517,
0.006914138,
0.1129571,
0.2264915,
0.2094788,
-0.2070... |
Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. | A comparison of the anticonvulsant and neurotoxic effects of cannabidiol (CBD), delta 9tetrahydrocannabinol, cannabinol and antiepileptic drugs (phenytoin, phenobarbital, carbamazepine, chlordiazepoxide, clonazepam, ethosuximide and trimethadione) was made in rats. Median effective potencies (ED 50 values) for maximal ... | 850,145 | [
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0.289115,
-... |
Effects of cytochalasin B and dimethylsulphoxide on isosmotic fluid transport by rabbit gall-bladder in vitro. | 1. Net fluid transport rate, transepithelial ohmic resistance and potential difference (p.d.), and unidirectional fluxes of Na+ were measured in rabbit gall-bladder preparations in vitro exposed on both sides to Ringer solutions of identical electrolyte composition. 2. Bilateral application of 1% dimethylsulphoxide (DM... | 850,153 | [
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0.09841021,
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0.04117099,
0.2654985,
0.003884195,
0.112... |
Reduction of potassium permeability by chloride substitution in cardiac cells. | 1. The efflux of radioactive K and Cl ions was measured in cow Purkinje fibres and ventricular preparations of cow, cat and frog. The effect of K and Cl was studied by changing the extracellular K concentration between zero and 54 mM, and by substituting Cl ions by acetylglycinate, isethionate, benzenesulphonate, propi... | 850,161 | [
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0.5203954,
0.2328845,
0.147649,
0.105519,
0.23... |
The release of vasopressin by nicotine: further studies on its site of action. | 1. In cats anaesthetized with chloralose the release of vasopressin in response to nicotine injections was examined. This release was measured by assaying the hormone in samples of venous blood. 2. Nicotine injections were given by three different routes, namely intravertebral, intracarotid and intravenous. The first t... | 850,196 | [
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0.0395938,
0.1747528,
-0.07212924,
-0.05903842,
0.22... |
Cellular and extracellular dehydration, and angiotensin as stimuli to drinking in the common iguana Iguana iguana. | 1. After water deprivation, the iguana promptly drank slightly more than enough water to restore the body fluids to isotonicity even under conditions of hypervolaemia. 2. In response to systemic injections of hypertonic solutions of NaCl and sucrose, the iguana drank and retained enough water to dilute the injected loa... | 850,202 | [
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0.2121391,
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0.0865855,
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0.2987852,
-0.07805207,
-0.01414947,
0.1963204,
0.2573499,
0.02166... |
Utilization of blood-borne and intramuscular substrates during continuous and intermittent exercise in man. | 1. Substrate utilization in the legs during bicycle exercise was studied in five subjects when performing intermittent intense exercise (15 sec work--15 sec rest) as well as continuous exercise during 60 min, with an almost identical average power output and oxygen uptake in both situations. 2. Muscle biopsies were obt... | 850,204 | [
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0.08686574,
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0.0392109,
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0.3776724,
0.1907973,
0.4516217,
-0.1496711,
... |
The permeability of the skin of a neotenous urodele amphibian, the mudpuppy Necturus maculosus. | 1. The permeability of the isolated skin of a neotenous urodele amphibian, the mudpuppy Necturus maculosus, to Na, Cl, urea and water was measured. 2. Unidirectional transcutaneous flux measurements and the action of ouabain and amiloride, showed that there was normally no active Cl or Na transport, nor a Cl/Cl exchang... | 850,206 | [
0.002237885,
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0.06180492,
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0.5009109,
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0.0625563,
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Accumulation of steroids in rabbit preimplantation blastocysts. | The concentrations of progesterone, androstenedione, testosterone, oestrone and oestradiol were measured by radioimmunoassay in blastocysts and uterine fluid flushings collected from rabbits 110 to 159 h post coitum (p.c.). None of the blastocysts or uterine flushings contained detectable levels of androstenedione, tes... | 850,212 | [
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0.1297449,
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0.1031504,
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0.2797037,
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0.2332521,
0.2780489,
-0.02383794,
-0... |
Histological changes in the cervix of the rabbit after coitus. | The histology of the rabbit ectocervix was investigated by light, transmission and scanning electron microscopy before and after insemination. The cervix became oedematous and heterophil polymorphs invaded the portio vaginalis within 30 min of mating or artificial insemination of whole semen, but not after insemination... | 850,220 | [
0.3224931,
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0.1223586,
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0.1498841,
0.5054837,
-0.04118766,
... |
Total syntheses of (+/-)-1-carbacefoxitin and -cefamandole and (+/-)-1-oxacefamandole. | The total syntheses of the (+/-)-1-carba analogues of cefoxitin (11), 7 alpha-methoxydeacetylcephalothin (5) and cefamandole (31) and the (+/-)-1-oxa analogue of cefamandole (43) are described. Their bioactivity spectra against 14 typical organisms are similar to those of their natural 1-thia counterparts, with the 1-c... | 850,241 | [
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0.5099145,
0.4766402,
0.09832663,
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... |
A preparatory course for medical students who lack a conventional academic background. | McMaster University School of Medicine admits students who may not have had an extensive education in physics, chemistry, and biology. For several years a short preliminary course was offered to those students. The course has since been discontinued, and its objectives have been incorporated into the M.D. program. This... | 850,255 | [
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0.2762597,
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0.007454631,
... |
The independent study program at the University of Wisconsin Medical School. | A program for 30 additional medical students for the first two years of the University of Wisconsin Medical School curriculum has been developed, and two groups of students have advanced to the clinical years. Design included providing modules of course materials to students and utilizing faculty predominantly in the d... | 850,257 | [
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0.3372455,
0.07679678,
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0.2746629,
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0.2204283,
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0.1365225,
... |
Transport and demand of oxygen in severe burns. | The balance equation or oxygen-conservation equation in which oxygen consumption is equal to cardiac output times the maximal oxygen binding capacity times the oxygen saturation difference between arterial and mixed venous blood shows the three factors by which the oxygen supply to the tissues can be regulated accordin... | 850,271 | [
-0.1152265,
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0.04794515,
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0.09466787,
0.2608744,
0.2352166,
0.1118366,
-0.20631... |
An uncommon fracture dislocation of the radius. | Two cases of fracture of the proximal third of the radius, one with anterolateral, and one with posterior dislocation of the radial head are described. In both the ulna remained intact. To the best of our knowledge, only one other similar case had been reported. | 850,282 | [
-0.3374429,
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0.3573789,
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0.04038858,
0... |
Functional contribution of autonomic innervation to urethral striated sphincter: studies with parasympathomimetic, parasympatholytic and alpha-adrenergic blocking agents in spinal cord injury and control male subjects. | Mechanisms underlying urethral pressure changes at the external sphincter region after administration of neuropharmacologic agents were investigated with cystosphincterometric studies and electromyography of the external urethral sphincter in adult patients with spinal cord injury and control male subjects. Bethanechol... | 850,325 | [
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0.1434033,
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0.02559823,
0.08239602,
0.1472... |
Deep hypothermia. | Early correction of congenital cardiac defects has been facilitated by the use of deep hypothermia and cardiocirculatory arrest. The technique currently used by us consists of surface cooling to 24 degrees C, total hemodilution, cardiopulmonary bypass to 20 degrees C and complete cardiocirculatory arrest. Rewarming is ... | 850,333 | [
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0.275085,
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0.04463744,
0.05879541,
0.2765948,
-0.05699957,
... |
[A new apparatus for testing binocular vision (author's transl)]. | The Optometer can be used in a binocular manner if the loupe-lens is replaced by a concave mirror of appropriate size and form. The concave mirror or the plane mirror connected to it can be partially transparent. With an appropriate arrangement of these elements the test field can be seen in free space. The image can b... | 850,350 | [
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0.06555789,
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0.4140819,
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0.01865586,
0.2997825,
-0.1235403,
-0.0141879... |
[A comparative study of the difference in the evolution of refraction in the two eyes in patients with convergent strabismus (author's transl)]. | In 329 cases of concomitant convergent strabismus, the alterations of refraction in the two eyes were compared over periods ranging from 10 to 30 years. In the group with unilateral strabismus (245 cases), a significant difference between the two eyes was observed. The change of refraction, if any, in the non-fixing ey... | 850,358 | [
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0.03116302,
-0.12... |
[Development of refraction and visual acuity of squinting children (author's transl)]. | The refraction and visual acuity rates of 170 children from the age of 2 to the age of 7 suffering from squint were recorded and analysed. On the basis of our investigation we could not prove the process of emmetropisation during the growth of the eyes of squinting children in this age group. That means that the proces... | 850,359 | [
-0.2727579,
0.08504494,
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0.3280796,
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0.1825439,
0.2816911,
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... |
The parasitic ecology of the rodent mite, Myobia musculi. IV. Life cycle. | The life cycle of Myobia musculi was determined by daily examination (under anesthesia) of experimentally infested mice. It was found that the larval period lasted 10 days followed by a 5-day nymphal period. Adult forms were seen on the 16th day. Adults produced fertile eggs within 24 hours of their appearance and eggs... | 850,386 | [
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0.08716084,
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0.2635991,
0.3987185,
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... |
Malignant neoplasms of the nasal cavities and paranasal sinuses: (a retrospective study). | This study presents a retrospective look at 115 patients evaluated here from 1957 to 1974. In this series, 57 percent were males and 43 percent females, 84 percent were Caucasian and 16 percent Negro. Lesions confined to or originating in the antrum made up 67 percent while nonantral lesions were 33 percent. Mean age a... | 850,451 | [
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0.2196404,
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Some considerations concerning institutional placement of retarded children. | The question whether retarded children should be institutionalized is discussed in the light of how, on the one hand, children can be successfully cared for at home and, more extensively, the serious problems that often arise at home. Institutions are not seen as the dreaded places they are often believed to be, and th... | 850,497 | [
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0.09283694,
0.1533639,
0.2606233,
... |
Magnetic enhancement of electron dose distribution in a phantom. | We have measured the effect of a 10-kG magnetic field on the dose distribution of electrons in a polystyrene phantom. Isodensity plots and depth-dose curves are presented for 22- and 28-MeV electron beams with and without the magnetic field applied. The measurements show that magnetic fields as low as 10 kG can produce... | 850,509 | [
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0.2602824,
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0.07340554,
0.5161176,
0.2800436,
0.2884018... |
[Intestinal complications during a course of vascular reconstructive surgery. Case reports]. | Twenty-one cases of gastro-enteric complications during aorto-iliac-femoral reconstructive surgery carried out from 1965 to 1973 in the Department of Surgery of University in Milan are studied. Causes, frequence, clinical data and medical and surgical procedures are discussed. | 850,544 | [
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... |
Fetal lung maturation. III. The amniotic fluid cortisol/cortisone ratio in preterm human delivery and the risk of respiratory distress syndrome. | Cortisol and cortisone have been measured in amniotic fluid samples obtained within 24 hours of deliver of 50 premature infants. When expressed as cortisol/cortisone ratios, the ratio tends to rise with advancing gestational age, although statistical significance is not attained. Both cortisol concentration and the cor... | 850,564 | [
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0.2161062,
0.09862823,
0.07894382,
0.6252511,
0.01776424,
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Maternal mortality due to ectopic pregnancy. A review of 102 deaths. | Ectopic pregnancy represents an increasing proportion of direct maternal deaths which has reached 10%. Between 1950 and 1974 there were 102 deaths from early ectopic pregnancy reviewed by the Michigan Maternal Mortality Committee. These cases were analyzed by status on admission and compared to a control series treated... | 850,569 | [
-0.3212609,
0.1923177,
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0.05705225,
0.1155729,
0.02887382,
-0.3236348,
0.09640895,
0.313259,
-0.094063... |
Stage II endometrial adenocarcinoma. Memorial Hospital for Cancer, 1949-1965. | Of 617 patients receiving initial therapy for endometrial adenocarcinoma from 1949 to 1965, 90 patients were retrospectively assigned to Stage II (FIGO) by reviewing preoperative, operative, and pathologic findings. In 66 patients (73%) the cervical spread of endometrial cancer was occult and detected only microscopica... | 850,578 | [
0.09148911,
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0.191192,
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0.5104565,
0.03988394,
0.2619222,
0.3502058,
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0.... |
Early pregnancy on the diaphragm with endometriosis. | The source of hemorrhage in a young woman who required emergency laparotomy for intraabdominal bleeding was found to be a very early primary pregnancy implanted on the undersurface of the right diaphragm, far behind the dome of the liver. Immediately adjacent to this lesion were three tiny foci of endometriosis. This c... | 850,582 | [
-0.1773638,
0.4640283,
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0.3216551,
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-0.1412532,
0.122488,
-0.6759906,
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0.2415919,
-0.125115... |
Epidemiologic studies of measles, measles vaccine, and subacute sclerosing panencephalitis. | Histories obtained in 350 of 375 clinically cofirmed cases of subacute sclerosing panencephalitis (SSPE) reported to a national registry showed that 292 patients had measles and 58 had no history of measles. Forty of the latter patients received live, attenuated measles virus vaccine. In patients with a history of meas... | 850,592 | [
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0.1016259,
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0.0756086,
0.08849797,
0.1944979,
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0.124661,
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0.2643624,
0.1458933,
0.3247231,
0.1050448,
0.2822961,
0.37972,
-0.1819119,
-0.29... |
Osteoid osteoma in children and young adults. | Osteoid osteoma is a relatively common benign tumor of bone which occurs most often in adolescents and young adults. The pattern of the pain with its characteristic response to aspirin and the roentgenographic findings make the clinical diagnosis easy and virtually certain. An example is presented to help the pediatric... | 850,593 | [
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0.1358113,
-0.06506467,
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0.2886668,
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0.3403013,
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-0.2521557,
0.3868271,
0.3854513,
0.1074349,
0.5250912,
-0.06160017,
-0.2370592,
... |
Gram-negative cerebrospinal fluid shunt-associated infections. | Twenty hydrocephalic children with cerebrospinal fluid (CSF) shunts over an 11-year period were seen with Gram-negative central nervous system (CNS) infections. Seventeen infections were with single organisms and three were mixed. Sixteen of 20 (80%) of the infections occurred within five months of shunt surgery. Compl... | 850,601 | [
0.1172943,
0.1143651,
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0.1289685,
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0.0628193,
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0.08199289,
0.1742343,
0... |
Erythromycin prophylaxis for pertussis. | A neonate admitted to the newborn nursery was found to have bacteriologically proven Bordetella pertussis whooping cough, and two of seven infants exposed to this child became infected. Erythromycin administration to the seven infants apparently prevented further infection as well as the appearance of clinical disease ... | 850,603 | [
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0.1159073,
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-0.125515,
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0.06061136,
0.168992... |
Interactions between delta9-tetrahydrocannabinol and phencyclidine hydrochloride in rats. | delta9-Tetrahydrocannabinol (THC; 2.5, 5.0, 10.0 mg/kg, PO) impaired avoidance and rotarod performance, and caused bradycardia and hypothermia. Phencyclidine (PCP; 1.25, 2.5, 5.0 mg/kg, IP) impaired avoidance and rotarod performance and caused a marked increase in photocell activity. When combined, the depressant prope... | 850,686 | [
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-0.3250781,
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0.2423756,
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0.1553711,
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0.3305257,
0.01266296,
0.05842947,
0.01169644,... |
[The merits of transaxillary aortography with a special catheter (author's transl)]. | 230 percutaneous transaxillary aortographies are described using a new type of catheter which simplifies the catherterization and diminishes complications. There is no difference between the complication rate of the transaxillary and the transfemoral techniques. The translumbal approach shows significantly more serious... | 850,743 | [
0.009956461,
0.0599468,
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0.04902,
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0.2353567,
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0.03425934,
0.3041438,
0.08064572,
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0... |
Major innervation of newborn rat cortex by monoaminergic neurons. | A major monoaminergic innervation in infant rat neocortex, predominantly in layer IV, has been demonstrated by ultrastructural and biochemical studies after the administration of exogenous catecholamine precursors and congeners. One-third of all cortical synapses have an uptake-storage mechanism for catecholamines. In ... | 850,788 | [
-0.1287408,
0.02161373,
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0.2185666,
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0.1438178,
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0.109042,
0.2778273,
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0.1163643,
0.1403515,
0.3991697,
0.3432861,
-0.01962137,
... |
Classical conditioning with auditory discrimination of the eye blink in decerebrate cats. | Cats were subjected to complete lower brainstem transection, and were then tested for learning ability according to a classical conditioning paradigm. An auditory stimulus was systematically paired with a brief shock to the eyelid. Within a few weeks after the operation, the decerebrate cats could learn the conditioned... | 850,800 | [
0.1206235,
0.1546298,
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0.02279228,
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0.1673732,
0.1050994,
0.02317894,
0.03348069,
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0.1850463,
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-0.2932117,
-0.005703923,
-0.157378,
-0.1106488,
0.1170453,
0.01386853,
0.238936,... |
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