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AACR-FDA-NCI Cancer Biomarkers Collaborative Consensus Report: Advancing the Use of Biomarkers in Cancer Drug Development | Recent discoveries in cancer biology have greatly increased our understanding of cancer at the molecular and cellular level, but translating this knowledge into safe and effective therapies for cancer patients has proved to be challenging. There is a growing imperative to modernize the drug development process by incor... | https://aacrjournals.org/clincancerres/article/16/13/3299/11147/AACR-FDA-NCI-Cancer-Biomarkers-Collaborative |
Mini-review. Application of combinatorial library methods in cancer research and drug discovery | Combinatorial chemistry is now considered as one of the most important recent advances in medicinal chemistry. There are five general approaches in combinatorial peptide library methods: biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring dec... | https://www.ingentaconnect.com/content/cog/antcan/1997/00000012/00000003/art00001 |
Translating cancer research into targeted therapeutics | The emphasis in cancer drug development has shifted from cytotoxic, non-specific chemotherapies to molecularly targeted, rationally designed drugs promising greater efficacy and less side effects. Nevertheless, despite some successes drug development remains painfully slow. Here, we highlight the issues involved and su... | https://www.nature.com/articles/nature09339 |
Guidelines for the welfare and use of animals in cancer research | Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the... | https://www.nature.com/articles/6605642 |
Hiding in plain view: the potential for commonly used drugs to reduce breast cancer mortality | Many medications have been developed for one purpose but then are found to have other clinical activities. There is tremendous interest in whether non-cancer medications may potentially have effects on breast cancer survival. In this review article, we have presented and evaluated the evidence for several commonly used... | https://link.springer.com/article/10.1186/bcr3336 |
Computational models for predicting drug responses in cancer research | The computational prediction of drug responses based on the analysis of multiple types of genome-wide molecular data is vital for accomplishing the promise of precision medicine in oncology. This will benefit cancer patients by matching their tumor characteristics to the most effective therapy available. As larger and ... | https://academic.oup.com/bib/article/18/5/820/2562791 |
Organoids in cancer research | The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues for the development of novel, more physiological human cancer models. Such preclinical models are essential for more efficient translation of basic cancer research into novel treatment regimens for patients with cancer. ... | https://www.nature.com/articles/s41568-018-0007-6 |
Long-term Use of Cholesterol-Lowering Drugs and Cancer Incidence in a Large United States Cohort | HMG-coA reductase inhibitors, commonly known as statins, account for the great majority of cholesterol-lowering drug use. However, little is known about the association between long-term statin use and incidence of most types of cancers. We examined the association between long-term use of cholesterol-lowering drugs, p... | https://aacrjournals.org/cancerres/article/71/5/1763/569918/Long-term-Use-of-Cholesterol-Lowering-Drugs-and |
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research | Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown ... | https://aacrjournals.org/cancerdiscovery/article/4/9/998/6397/Patient-Derived-Xenograft-Models-An-Emerging |
Therapeutic Nanoparticles for Drug Delivery in Cancer | Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs... | https://aacrjournals.org/clincancerres/article/14/5/1310/179797/Therapeutic-Nanoparticles-for-Drug-Delivery-in |
Cancer Cell Lines for Drug Discovery and Development | Despite the millions of dollars spent on target validation and drug optimization in preclinical models, most therapies still fail in phase III clinical trials. Our current model systems, or the way we interpret data from them, clearly do not have sufficient clinical predictive power. Current opinion suggests that this ... | https://aacrjournals.org/cancerres/article/74/9/2377/599415/Cancer-Cell-Lines-for-Drug-Discovery-and |
Novel Chemotherapeutic Drugs in Sphingolipid Cancer Research | Sphingolipid-metabolizing enzymes are becoming targets for chemotherapeutic development with an increasing interest in the recent years. In this chapter we introduce the sphingolipid family of lipids, and the role of individual species in cell homeostasis. We also discuss their roles in several rare diseases and overal... | https://link.springer.com/chapter/10.1007/978-3-7091-1368-4_12 |
Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs | We analyzed data from the prospective Women’s Health Initiative (WHI) Observational Study to examine the effects of regular use of aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer risk. We studied a population of 80,741 postmenopausal women between 50 and 79 years of age who ... | https://aacrjournals.org/cancerres/article/63/18/6096/510377/Breast-Cancer-and-Nonsteroidal-Anti-Inflammatory |
From microRNA functions to microRNA therapeutics: Novel targets and novel drugs in breast cancer research and treatment | MicroRNAs (miRNAs or miRs) are a family of small non‑coding RNAs that regulate gene expression by the sequence-selective targeting of mRNAs, leading to translational repression or mRNA degradation, depending on the degree of complementarity with target mRNA sequences. miRNAs play a crucial role in cancer. In the case o... | https://www.spandidos-publications.com/10.3892/ijo.2013.2059 |
A History of Cancer Chemotherapy | The use of chemotherapy to treat cancer began at the start of the 20th century with attempts to narrow the universe of chemicals that might affect the disease by developing methods to screen chemicals using transplantable tumors in rodents. It was, however, four World War II–related programs, and the effects of drugs t... | https://aacrjournals.org/cancerres/article/68/21/8643/541799/A-History-of-Cancer-Chemotherapy |
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