pubid int64 8.03M 27.8M | question stringlengths 58 214 | context dict | long_answer stringlengths 76 748 | final_decision stringclasses 2
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|---|---|---|---|---|
17,279,058 | Is endogenous estrogen associated with cognitive performance before , during , or after menopause? | {
"contexts": [
"In a population-based sample of women (45, 50, or 55 years old), behavioral data and blood serum were collected concurrently, enabling us (1) to investigate cognitive differences among premenopausal, perimenopausal, and postmenopausal groups of women and (2) to evaluate the relationship between b... | These results do not support the hypothesis that estrogen or menopausal status affects cognitive performance in middle-aged women. | no |
22,773,318 | Are physical activity/fitness peaks during perimenopause and BMI change patterns associated with baseline activity/fitness in women : a longitudinal study with a median 7-year follow-up? | {
"contexts": [
"To assess the age-associated longitudinal trends in cardiorespiratory fitness (CRF), leisure-time physical activity (PA), and body mass index (BMI) across the lifespan in a cohort of adult women.",
"The sample included 1467 women from the Aerobics Center Longitudinal Study who were 30-79 year... | We concluded that the age-related longitudinal patterns in physical activity and fitness are not linear. Baseline activity and fitness levels are associated with BMI status during adulthood, but do not affect BMI change trajectory. | no |
21,892,111 | Is c-reactive protein associated with aortic stiffness in a cohort of African American and white women transitioning through menopause? | {
"contexts": [
"Arterial stiffness is a marker of cardiovascular health. Arterial stiffness and C-reactive protein (CRP) are linked to cardiovascular outcomes. Increases in both inflammation and arterial stiffness are known to occur with menopause. The association between CRP and arterial stiffness is well accep... | Menopause is strengthening the association between CRP and PWV, independent of age, and this effect seems to be stronger among African American women. This study provides a potential mechanism for the increased risk of cardiovascular disease among postmenopausal women. | yes |
22,334,057 | Does menopause affect pain depending on pain type and characteristics? | {
"contexts": [
"Women are more affected than men by many chronic pain conditions, suggesting the effect of sex-related mechanisms in their occurrence. The role of gonadal hormones has been studied but with contrasting results depending on the pain syndrome, reproductive status, and hormone considered. The aim of... | The present study provides preliminary data suggesting that menopause can affect pain depending on the painful condition experienced by the woman. This underlines the different interactions of menopause-related events with body structures involved in pain. | yes |
15,037,410 | Is age at natural menopause linked with the follicle-stimulating hormone receptor region : a sib-pair study? | {
"contexts": [
"Studies have shown that age at natural menopause is heritable. Mutations in the FSH-receptor have been identified in women with premature ovarian failure (POF) and the FSH-receptor gene may, therefore, be considered a candidate gene for (early) menopausal age. This study investigates whether ther... | Possibly, age at natural menopause in the more or less normal range is not part of the spectrum of phenotypes determined by mutations in the FSH-receptor gene. Alternatively, our results might be explained by genetic heterogeneity in the left tail of the distribution of menopausal age. This can limit the chance of find... | no |
11,595,778 | Are obesity and sarcopenia after menopause reversed by sex hormone replacement therapy? | {
"contexts": [
"Menopause is linked to an increase in fat mass and a decrease in lean mass exceeding age-related changes, possibly related to reduced output of ovarian steroids. In this study we examined the effect of combined postmenopausal hormone replacement therapy (HRT) on the total and regional distributio... | HRT is linked to the reversal of both menopause-related obesity and loss of lean mass, without overall change in body weight. The increase in lean body mass during HRT is likely explained by muscle anabolism, which in turn, prevents disease in the elderly. | yes |
11,919,494 | Does the impact of pregnancy and menopause on CD4 lymphocyte count in HIV-infected women? | {
"contexts": [
"To determine indirectly the effect of changes in levels of reproductive hormones on CD4 lymphocyte counts by investigating the impact of pregnancy and menopause on CD4 lymphocyte counts in HIV-infected women.",
"Participants were 382 women with a known interval of HIV seroconversion. Review o... | The results suggest that CD4 lymphocyte counts differ between pre- and postmenopausal women, perhaps because of changes in the level of reproductive hormones in the menopause, but associations were not statistically significant. Pregnancy had no statistically significant effect on CD4 lymphocyte counts. | yes |
12,615,819 | Is poor response to ovulation induction a stronger predictor of early menopause than elevated basal FSH : a life table analysis? | {
"contexts": [
"During the course of assisted reproduction treatment, a number of women exhibit a \"poor response\" to ovulation induction, or demonstrate an elevated basal FSH level (> or =10 IU/l) at a young age. We sought to determine whether these women are at increased risk of early menopause and poor repro... | Both poor response to ovarian stimulation and raised basal FSH are markers of reduced ovarian reserve and predict an increased risk of early menopause. | yes |
15,545,788 | Are antral follicle counts related to age at natural fertility loss and age at menopause? | {
"contexts": [
"The variability in ultrasound-based antral follicle counts sized 2-10 mm after allowing for age-related decline is considerable. This may represent differences in actual reproductive age among women. This hypothesis was tested by cohort comparison for distribution of age at occurrence of reproduc... | The link between declining antral follicle counts and reproductively significant events like loss of natural fertility and menopause is strengthened by the high degree of similarity among the predicted and observed age distributions. Predictive usefulness of this relationship in a clinical setting may be more marginal,... | yes |
23,715,377 | Are disruptions in ovarian function related to depression and cardiometabolic risk during premenopause? | {
"contexts": [
"The aim of this study was to evaluate the extent to which mild disruptions in ovarian function, indexed by changes in menstrual cycle length, may relate to cardiometabolic and psychological health in premenopausal women.",
"Among 804 healthy, regularly cycling women (aged 25-45 y; mean [SD] a... | Findings suggest that disruptions in ovarian function, marked by subtle changes in menstrual cycle length, may relate to aspects of cardiometabolic and psychological health among healthy, premenopausal women. | yes |
8,538,481 | Is creatinine clearance at menopause related to bone mass in later life? | {
"contexts": [
"To investigate whether creatinine clearance (Ccr) at menopause is related to bone mass later in life.",
"Ccr was measured within 5 years after natural menopause in two groups of normal women. Bone mineral content (BMC) of the distal forearm, lumbar spine, and proximal femur were measured by p... | Low Ccr within the normal range at menopause is not an independent risk factor for osteopenia in later life. | no |
15,772,559 | Are plasminogen-activator inhibitor-1 polymorphisms associated with obesity and fat distribution in the Quebec Family Study : evidence of interactions with menopause? | {
"contexts": [
"Obesity is associated with increased plasma levels of plasminogen-activator inhibitor-1 (PAI1), the major fibrinolysis inhibitor. PAI1 levels are also increased at menopause, a condition that is associated with fat mass gain, especially in the abdominal area.",
"We hypothesized that genetic v... | Taken together, these results suggest that the PAI1 gene is associated with obesity and may modulate the changes in adipose tissue distribution generally observed at menopause. | yes |
22,639,915 | Do green tea catechins decrease oxidative stress in surgical menopause-induced overactive bladder in a rat model? | {
"contexts": [
"What's known on the subject? and What does the study add? Ovary hormone deficiency and the age-related changes in post-menopausal women are subjected to a number of urological dysfunctions, including overactive bladder syndrome. Green tea is a popular healthy drink worldwide and its extract catec... | Ovariectomy increased oxidative damage, enhanced voiding frequency and decreased bladder compliance. EGCG could restore ovariectomy-induced bladder dysfunction in a dose-dependent fashion through antioxidant, anti-fibrosis and anti-apoptosis effects. | yes |
18,063,808 | Does time since menopause influence the acute and chronic effect of estrogens on endothelial function? | {
"contexts": [
"We evaluated whether time since menopause influences the acute and chronic effect of Estradiol (E) on vascular endothelial function.",
"We studied flow-mediated dilatation (FMD) in 134 postmenopausal women (PMW) before and after acute and chronic E administration. At baseline FMD was inversel... | Time from menopause influences FMD in PMW. The acute and chronic effect of E on FMD is time dependent and is reduced by a longer time since menopause. | yes |
19,058,936 | Is a polymorphism of apolipoprotein E ( APOE ) gene associated with age at natural menopause in Caucasian females? | {
"contexts": [
"The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females.",
"Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelate... | Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women. | yes |
21,738,079 | Does estrogen receptor β-selective phytoestrogenic formulation prevent physical and neurological changes in a preclinical model of human menopause? | {
"contexts": [
"As an alternative to estrogen therapy, the efficacy of an estrogen receptor β-selective phytoestrogenic (phyto-β-SERM) formulation to regulate climacteric symptoms and decline in brain responses associated with ovarian hormone loss in menopause was assessed.",
"A phyto-β-SERM formulation-cont... | Overall, the phyto-β-SERM diet induced physical and neurological responses comparable with ovary-intact mice, suggesting the therapeutic potential of the phyto-β-SERM formulation for the prevention/alleviation of climacteric symptoms and decline in brain responses induced by ovarian hormone loss, which provides the bas... | yes |
17,636,279 | Is a polymorphism in the AMH type II receptor gene associated with age at menopause in interaction with parity? | {
"contexts": [
"Anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment in the mouse ovary. We hypothesize that in women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component, we inve... | The observed association of the AMHR2 -482 A > G polymorphism with natural age at menopause suggests a role for AMH signaling in the usage of the primordial follicle pool in women. | yes |
23,096,246 | Does assessment of sleep quality and correlate in a large cohort of Colombian women around menopause? | {
"contexts": [
"The aim of this study was to determine the relationship between self-reported sleep quality, menopausal symptom intensity, and correlates (including ethnicity) among middle-aged women.",
"The present cross-sectional study involved 1,078 Colombian women aged 40 to 59 years who completed the Pi... | Despite study limitations, poor sleep quality is highly prevalent in this large middle-aged Colombian female sample and is related to menopausal symptom severity, tobacco use, and presence of hypertension. | yes |
8,607,941 | Is menopause associated with a significant increase in blood monocyte number and a relative decrease in the expression of estrogen receptors in human peripheral monocytes? | {
"contexts": [
"The clinical significance of the differential expression of estrogen receptor (ER) in human monocytes was evaluated.",
"Two color flow cytometry analysis was used on peripheral blood samples of young and postmenopausal females and postmenopausal females treated with estrogen replacement thera... | These findings suggest that estrogen modulates the monocyte numbers and its effects may be mediated through the ER in the monocytes. | yes |
21,506,883 | Is age at menarche and menopause associated with two common genetic variants in the methylenetetrahydrofolate reductase ( MTHFR ) gene? | {
"contexts": [
"The study aimed at investigating the independent and the combined effects of the two common genetic variants in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C > T and 1298A > C, and their interaction with lifestyle factors on timing of menarche and natural menopause.",
"Postmenopa... | We were unable to replicate previous findings suggesting that the MTHFR gene influences the onset of menarche and natural menopause. The interaction effect between the 677C >T genetic variant and duration of breastfeeding on the timing of natural menopause requires further investigation. | no |
21,500,999 | Is mediterranean climate associated with early age at menopause and low high-density lipoprotein in postmenopausal women? | {
"contexts": [
"The aim of this study was to investigate the effect of three different climates on age at menopause and metabolic factors in postmenopausal women.",
"Study population consisted of 232 postmenopausal women with natural menopause who admitted to Dr. Sami Ulus Maternity and Women's Health Teachi... | Mediterranean climate is associated with early menopause and low HDL levels. | yes |
19,318,449 | Does adrenal androgen production capacity remain high up to menopause in women with polycystic ovary syndrome? | {
"contexts": [
"Hyperandrogenism is one of the main features of polycystic ovary syndrome (PCOS). Of circulating androgens, 50% of androstenedione and testosterone are of ovarian and adrenal origin, whereas dehydroepiandrosterone (DHEA) and DHEA sulfate are almost uniquely of adrenal origin. Our previous studies... | Similarly to ovarian endocrine function, serum adrenal steroid levels and adrenal steroid production capacity remain enhanced at least up to menopause in women with PCOS. | yes |
17,023,721 | Does intervention with a low-fat , high-carbohydrate diet influence the timing of menopause? | {
"contexts": [
"Later age at menopause is associated with a greater risk of breast cancer. Dietary factors may at least partially influence breast cancer risk through an effect on the age at menopause.",
"We studied the effect of a low-fat, high-carbohydrate (LFHC) dietary intervention on the timing of menop... | Overall, the LFHC dietary intervention did not influence the timing of menopause. Factors associated with age at menopause in this population were consistent with those reported in other populations. | no |
22,168,600 | Is adipose tissue IL-8 increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women? | {
"contexts": [
"The menopausal transition is characterized by increased body fat accumulation, including redistribution from peripheral to central fat depots. This distribution is associated with an increased risk of type 2 diabetes and cardiovascular disease that are linked to low-grade inflammation. We determi... | Postmenopausal women have an increased inflammatory response in the subcutaneous fat and circulation. Inflammatory markers in adipose tissue decreased significantly after surgery-induced weight loss. This effect may be beneficial for metabolic control and reduced cardiovascular risk after weight loss. | yes |
16,303,830 | Does menopause modify the association of leukocyte telomere length with insulin resistance and inflammation? | {
"contexts": [
"Leukocyte telomere length is inversely correlated with age, insulin resistance, serum leptin, and smoking.",
"We explored whether menopausal status modifies the relations between leukocyte telomere length and insulin resistance. In addition, we examined the effect of menopause on the relation... | Menopausal status impacts leukocyte telomere length and its relation with insulin resistance and inflammation in women. | yes |
19,833,786 | Does gait variability detect women in early postmenopause with low bone mineral density? | {
"contexts": [
"Women in early postmenopause and with low bone mineral density (BMD) may exhibit early markers for physical frailty as a result of sarcopenia and osteopenia.",
"The purpose of this study was to determine whether women in early postmenopause and with low BMD exhibit decreased physical performa... | The limitations of this study included group assignment on the basis of the results of the most recent bone density scan within the preceding 2 years. | yes |
27,093,617 | Is menopause status associated with circadian- and sleep-related alterations? | {
"contexts": [
"The aim of the study was to investigate whether postmenopausal women show differences in circadian-related variables and sleep characteristics compared with premenopausal women, and to analyze potential associations between these circadian-related variables and abdominal fat distribution or metab... | Postmenopausal women exhibit loss of circadian robustness and an increase in sleep abnormalities compared with premenopausal women. | yes |
8,033,370 | Does 17 beta-oestradiol counteract the formation of the more acidic isoforms of follicle-stimulating hormone and luteinizing hormone after menopause? | {
"contexts": [
"When the gonadotrophin levels increase at midcycle, more basic isoforms of FSH and LH appear in the circulation. However, when these gonadotrophins increase at menopause more acidic forms appear. The present study was done to see whether chronic 17 beta-oestradiol (E2) administration to post-meno... | Chronic E2 administration to post-menopausal women counteracted the formation of more acidic isoforms of both FSH and LH after the menopause. | yes |
26,139,426 | Is anti-mullerian hormone ( AMH ) associated with natural menopause in a population-based sample : The CARDIA Women 's Study? | {
"contexts": [
"AMH is associated with menopausal timing in several studies. In contrast to prior studies that were restricted to women with regular cycles, our objective was to examine this association in women with either regular or irregular menstrual cycles.",
"CARDIA is a longitudinal, population-based ... | AMH is independently associated with natural menopause. AMH appears most useful in identifying women at risk of menopause in the near future (within 3 years of AMH measurement). | yes |
15,167,829 | Is vaginal pH similar to follicle-stimulating hormone for menopause diagnosis? | {
"contexts": [
"This paper is intended to demonstrate whether vaginal pH value is associated with menopausal status and symptoms, to review the sensitivity of follicle-stimulating hormone or vaginal pH to diagnose menopause, to compare these findings to a group of practice patients, and to determine whether vagi... | In women without vaginitis and no estrogen therapy, a vaginal pH of > 4.5 indicates menopause, because it demonstrates a similar sensitivity as follicle-stimulating hormone in epidemiologic studies. In the practice patients, the sensitivity of follicle-stimulating hormone was no different than vaginal pH in the diagnos... | yes |
24,435,779 | Is anti-Mullerian hormone a more accurate predictor of individual time to menopause than mother 's age at menopause? | {
"contexts": [
"In the prediction of time to menopause (TTM), what is the added value of anti-Müllerian hormone (AMH) when mother's age at natural menopause (ANM) is also known?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Age Factors",
"Anti-Mullerian Hormone",
"Female",
... | AMH is a more accurate predictor of individual TTM than mother's age at menopause. | yes |
24,398,409 | Is menopause associated with self-reported poor sleep quality in women without vasomotor symptoms? | {
"contexts": [
"The aim of this study was to investigate the relationship between menopause and self-reported sleep quality in Chinese women without vasomotor symptoms.",
"Cross-sectional data were collected from a decoded database of the National Cheng Kung University Hospital. Menopause was defined as abse... | Postmenopausal women without vasomotor symptoms have significantly higher global PSQI scores and a higher risk of being poor sleepers than premenopausal women. In addition, menopause and snoring are associated with an increased risk of poor self-reported sleep quality independently of cardiometabolic factors and lifest... | yes |
21,167,831 | Is early menopause associated with lack of response to antiviral therapy in women with chronic hepatitis C? | {
"contexts": [
"Chronic hepatitis C (CHC) and liver fibrosis progress more rapidly in men and menopausal women than in women of reproductive age. We investigated the associations among menopause, sustained virologic response (SVR), and liver damage in patients with CHC.",
"We performed a prospective study of... | Among women with CHC, early menopause was associated with a low likelihood of SVR, probably because of inflammatory factors that change at menopause. | yes |
21,177,795 | Does hyperandrogenism in women with polycystic ovary syndrome persist after menopause? | {
"contexts": [
"Ovarian and adrenal hyperandrogenism characterize premenopausal women with polycystic ovary syndrome (PCOS). Androgens decline with age in healthy and PCOS women.",
"The objective of the study was to investigate hyperandrogenism in PCOS after menopause.",
"This was a case-control, cross-s... | In postmenopausal PCOS women, ACTH and cortisol responses to CRH are normal. Androgen levels at baseline are higher in PCOS than control women and remain increased after ACTH stimulation. The dexamethasone suppression results in postmenopausal PCOS women suggest that DHEAS and total T are partially of adrenal origin. A... | yes |
19,361,458 | Are circulating concentrations of monocyte chemoattractant protein-1 associated with menopause status in Korean women? | {
"contexts": [
"Monocyte chemoattractant protein-1 (MCP-1) plays a role in adipose tissue inflammation and insulin resistance. Human circulating MCP-1 concentrations reportedly increase or remain unchanged according to obesity or insulin resistance in various ethnic populations; whether or not circulating MCP-1 ... | Circulating MCP-1 concentrations are associated with menopause status itself, irrespective of obesity; they do not correlate with obesity or insulin resistance in Korean women, most of whom are not severely obese. | yes |
25,884,698 | Are gene polymorphisms in RANKL/RANK/OPG pathway associated with ages at menarche and natural menopause in Chinese women? | {
"contexts": [
"Age at menarche (AAM) and age at natural menopause (AANM) have been shown intimately associated with woman's health later in life. Previous studies have indicated that AAM and AANM are highly heritable. RANKL/RANK/OPG signaling pathway is essential for mammary gland development, which is also fou... | The present study suggests that TNFRSF11A but not TNFSF11 and TNFRSF11B genetic polymorphisms are associated with AAM and AANM in Chinese women. The findings provide evidence that genetic variations in RANKL/RANK/OPG pathway may be associated with the onset and cessation of the menstruation cycle. | yes |
24,714,626 | Do diabetes and menopause aggravate age-dependent deterioration in arterial stiffness? | {
"contexts": [
"The present study was designed to evaluate the effects of menopause status and diabetes on arterial stiffness, metabolic parameters, and inflammatory parameters in premenopausal and postmenopausal women with and without type 2 diabetes mellitus.",
"In the present study, 186 women were divided... | Postmenopausal women without diabetes have significantly higher AI compared with premenopausal women without type 2 diabetes mellitus. The combination of diabetes and postmenopause status is associated with further deterioration of AI and PWV independently of age, body mass index, and other cardiovascular risk factors. | yes |
24,714,624 | Is aging , not menopause , associated with higher prevalence of hyperuricemia among older women? | {
"contexts": [
"This work aims to study the associations, if any, of hyperuricemia, gout, and menopause status in the US population.",
"Using multiyear data from the National Health and Nutrition Examination Survey, we performed unmatched comparisons and one to three age-matched comparisons of women aged 20 ... | Age is a better statistical explanation for the higher prevalence of hyperuricemia among older women than menopause status. | yes |
27,614,355 | Does length of FMR1 repeat alleles within the normal range substantially affect the risk of early menopause? | {
"contexts": [
"Is the length of FMR1 repeat alleles within the normal range associated with the risk of early menopause?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Alleles",
"Cross-Sectional Studies",
"Female",
"Fragile X Mental Retardation Protein",
"Genetic Associ... | The length of repeat alleles within the normal range does not substantially affect risk of early menopause. | no |
18,692,804 | Does occurrence of postmenopausal-like acidic follicle-stimulating hormone ( FSH ) isoforms precede the rise of FSH before menopause? | {
"contexts": [
"To assess the glycoform distribution patterns of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during the menstrual cycle at different ages and FSH levels, after menopause, and with premature ovarian failure (POF).",
"Controlled clinical study.",
"Healthy volunteers in a... | The occurrence of postmenopausal-like acidic FSH isoforms precedes the rise of FSH before menopause. | yes |
24,336,141 | Does age at surgical menopause influence cognitive decline and Alzheimer pathology in older women? | {
"contexts": [
"To determine the association between age at surgical menopause and both cognitive decline and Alzheimer disease (AD) pathology in 2 longitudinal cohorts.",
"Female subjects from 2 longitudinal studies of cognitive decline (Religious Orders Study and Rush Memory and Aging Project) were include... | Early age at surgical menopause was associated with cognitive decline and AD neuropathology. Ongoing studies should clarify the potential effect of HRT on this relationship. | yes |
14,501,610 | Does factor V Leiden mutation accelerate the onset of natural menopause? | {
"contexts": [
"Smoking is consistently associated with a younger age for menopause. Although this may be because of the direct toxic effects of tobacco smoke on follicles, we hypothesize that there may also be a relationship between smoking and a vascular origin of early menopausal onset. Several lifestyle fact... | We found that the factor V Leiden mutation was related, but not statistically significant, to an earlier age at menopause; smoking possibly enhances this effect. The mutation can be one of the genetic determinants of menopausal age operating through a vascular mechanism. | yes |
27,676,633 | Is relationship between equol producer status and metabolic parameters in 743 Japanese women : equol producer status associated with antiatherosclerotic conditions in women around menopause and early postmenopause? | {
"contexts": [
"Equol, an active metabolite possessing estrogen-like activity, is produced by the action of intestinal flora on soy isoflavones. There is an increasing evidence regarding its efficacy in the relief of menopausal symptoms, suppression of decreased bone mineral density, and lipid profile improvemen... | Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels. | yes |
25,994,816 | Are gene variants associated with age at menopause also associated with polycystic ovary syndrome , gonadotrophins and ovarian volume? | {
"contexts": [
"Is there a relationship between the genetic risk for polycystic ovary syndrome (PCOS) and genetic variants that influence timing of menopause?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Age Factors",
"Boston",
"Case-Control Studies",
"Cohort Studies",
"Female",
... | The genetic risk score, which sums the contribution of variants at all menopause loci, was associated with PCOS. | yes |
25,017,806 | Is menopause associated with lumbar disc degeneration : a review of 4230 intervertebral discs? | {
"contexts": [
"The main objective of this study was to investigate, in a population of normal postmenopausal women, the association between menopause and severity of lumbar disc degeneration from the first lumbar to the first sacral vertebra on magnetic resonance imaging.",
"Between January 2010 and May 201... | Menopause is associated with disc degeneration in the lumbar spine. The association almost entirely occurred in the first 15 years since menopause, suggesting estrogen decrease may be a risk factor for lumbar disc degeneration. | yes |
25,032,840 | Is passive smoking associated with lower age at menopause? | {
"contexts": [
"The aim of the study was to investigate the age at menopause in women exposed to passive smoking.",
"The study was designed as a case-control study. The main outcome measure was to compare the age at menopause of women exposed to second-hand smoking to non-exposed women.",
"The age at men... | Our findings suggest that earlier age at menopause should be added to the negative effects of passive smoking, in addition to increased risks for overall, cardiovascular and cancer mortality as well as increased risk for osteoporosis. | yes |
22,730,514 | Does hormonal environment affect cognition independent of age during the menopause transition? | {
"contexts": [
"Cognitive decline is prevalent in aging populations, and cognitive complaints are common during menopause. However, the extent of hormonal influence is unclear, particularly when considered independent of the aging process.",
"We sought to determine differences in cognitive function attributa... | Results suggest that verbal fluency mechanisms are vulnerable during the menopausal transition. Targeted intervention may preserve function of this critical cognitive domain. | yes |
27,326,816 | Is menopause associated with articular cartilage degeneration : a clinical study of knee joint in 860 women? | {
"contexts": [
"The purpose of this study was to investigate the association between menopause and severity of knee joint cartilage degeneration using a magnetic resonance imaging-based six-level grading system, with six cartilage surfaces, the medial and lateral femoral condyle, the femoral trochlea, the medial... | Menopause is associated with cartilage degeneration of knee joint. After menopause, cartilage showed progressive severe degeneration that occurred in the first 25 YSM, suggesting estrogen deficiency might be a risk factor of cartilage degeneration of the knee joint. Further studies are needed to investigate whether age... | yes |
20,042,893 | Is premature menopause associated with increased risk of cerebral infarction in Japanese women? | {
"contexts": [
": Few epidemiological studies have examined the relationship between age at menopause and stroke incidence, and none have done so in Japanese women. Here, we investigated the relationship between age at menopause and stroke incidence in a large group of Japanese women.",
": The study particip... | : Our data suggest that Japanese women who undergo menopause before age 40 years are at an increased risk of cerebral infarction. Premature menopause should be considered an indicator of the need for more aggressive medical intervention aimed at the prevention of cerebral infarction. | yes |
16,019,357 | Does time since menopause affect plasma viscosity , plasma thromboxane levels and Doppler findings? | {
"contexts": [
"To evaluate whether the use of transdermal hormone replacement therapy (HRT), in women within 5 years of menopause compared with women who were postmenopausal for > 5 years, would significantly influence thromboxane B2 levels, plasma viscosity and Doppler flow parameters at the level of the uteri... | Time since menopause does not affect the potential hemodynamic benefits of HRT in normal-weight women. | no |
22,248,077 | Are eSR1 , HK3 and BRSK1 gene variants associated with both age at natural menopause and premature ovarian failure? | {
"contexts": [
"Premature ovarian failure (POF) is a complex and heterogeneous disorder that is influenced by multiple genetic components. Numerous candidate gene studies designed to identify POF susceptibility loci have been published, but most positive findings have not been confirmed in follow up studies. We ... | This largest association study undertaken to determine correlation between POF and AANM/EM revealed three significant SNPs (rs2278493, rs2234693, and rs12611091). All are associated with not only AAWM and EM but also POF. Insights into shared genetic susceptibility between POF and AANM/EM will provide novel entry point... | yes |
24,038,017 | Does supplementation of omega-3 polyunsaturated fatty acids prevent increase in arterial stiffness after experimental menopause? | {
"contexts": [
"Menopause is associated with increased arterial stiffness, an independent marker of cardiovascular risk. Omega-3 polyunsaturated fatty acids (N3-PUFAs) are thought to have multiple cardiovascular benefits, including prevention of arterial stiffness. We investigated whether treatment with N3-PUFA ... | In an experimental model of menopause, N3-PUFA supplementation prevents arterial stiffening and other vascular changes induced by ovariectomy. These results represent a therapeutic benefit of N3-PUFAs in prevention of postmenopausal cardiovascular disease. | yes |
23,683,672 | Are genes responsible for vaginal extracellular matrix metabolism modulated by women 's reproductive cycle and menopause? | {
"contexts": [
"To analyze the expression of genes involved in extracellular matrix (ECM) biogenesis and remodeling in vaginal tissue of women with clinically normal pelvic floor support (defined as controls) according to the phase of menstrual cycle and postmenopausal women with and without pelvic organ prolaps... | Our results indicate that ovarian cycle and age-related changes influence the expression of genes encoding proteins responsible for ECM metabolism in human vagina. Moreover, POP is associated with alteration in vaginal ECM components after menopause. | yes |
15,501,350 | Is [ Menopause in 2004 : `` hormone replacement therapy '' what it used to be anymore ]? | {
"contexts": [
"The data concerning post-menopausal hormone replacement therapy (HRT) were recently completely modified. The aim of this review is to present the last studies about post-menopausal HRT and to describe new alternatives to this treatment.",
"In May 2002, the women's health initiative (WHI) tria... | The impact of the WHI trial on clinical practice was very important since then. The "Agence Francaise de sécurité sanitaire des produits de santé" (AFSSAPS) edited in May 2004 a public recommendation limiting indication for HRT to patients with severe climacteric symptoms. The treatment must now be prescribed for the s... | no |
27,023,864 | Are flexible parametric survival models built on age-specific antimüllerian hormone percentiles better predictors of menopause? | {
"contexts": [
"This study aimed to improve existing prediction models for age at menopause.",
"We identified all reproductive aged women with regular menstrual cycles who met our eligibility criteria (n = 1,015) in the Tehran Lipid and Glucose Study-an ongoing population-based cohort study initiated in 1998... | The model including the age-specific AMH percentiles as the covariate and using proportional odds as its covariate metrics meets all the statistical criteria for the best model and provides the most clinically relevant and realistic predictions for age at menopause for reproductive-aged women. | yes |
17,201,803 | Does the transition to menopause reinforce adiponectin production and its contribution to improvement of insulin-resistant state? | {
"contexts": [
"To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status.",
"We conducted a population-based, cross-sectional study of 207 premenopausal and 206 postmeno... | The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA-IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin-resistant state after, rather than before, menopause. | yes |
21,785,372 | Are serum estradiol levels associated with urinary incontinence in midlife women transitioning through menopause? | {
"contexts": [
"We evaluated the relationship between annually measured serum endogenous estradiol and the development or worsening of stress and urge incontinence symptoms during a period of 8 years in women transitioning through menopause.",
"This is a longitudinal analysis of women with incontinence in th... | We found that annually measured values and year-to-year changes in endogenous estradiol levels had no effect on the development or worsening of incontinence in women transitioning through menopause. | no |
20,395,877 | Are endothelial-mediated microcirculatory responses to an acute estradiol test influenced by time since menopause , cumulative hormone exposure , and vasomotor symptoms? | {
"contexts": [
"The aim of this study was to determine which factors could influence microcirculatory responses to an acute estradiol test during postmenopause.",
"Dynamic nailfold videocapillaroscopy was performed in 68 healthy 34- to 70-year-old postmenopausal women before and 1 hour after administration o... | Changes in RBCVs and TRBCVmax after estradiol administration indicate an increase in endothelial-dependent vasodilatation and vascular elasticity, respectively. Moreover, maintenance of endothelial responsiveness depends on cumulative exposure to sex steroids, duration of hormone deprivation, and triglyceride levels. P... | yes |
19,157,732 | Does menopause-specific questionnaire assessment in US population-based study show negative impact on health-related quality of life? | {
"contexts": [
"To use the Menopause-Specific Quality of Life Questionnaire (MENQOL) to assess the impact of menopausal symptoms on health-related quality of life in a large US population-based study.",
"Participants were recruited from the US population through random-digit-dialing and probability sampling.... | Symptoms experienced during menopause and socio-demographic characteristics affect the quality of life in postmenopausal women. Hot flashes impact the daily activities of most postmenopausal women, especially those with more frequent/severe symptoms. Treatments that safely and effectively treat these symptoms could imp... | yes |
10,430,192 | Do biochemical markers of bone turnover decline after menopause in healthy women? | {
"contexts": [
"To investigate the duration of high bone turnover after menopause in normal healthy women.",
"Study recruited from three screening studies for health care in the elderly held in the area of Hamamatsu city.",
"Department of Orthopaedic Surgery, Hospital at Hamamatsu University School of Me... | High bone turnover occuring after menopause lasts for >25 years during the postmenopausal period. | no |
21,972,241 | Is early menopause an independent predictor of rheumatoid arthritis? | {
"contexts": [
"As rheumatoid arthritis (RA) occurs more often in women than in men, it has been suggested that reproductive hormones may play an important role in the pathogenesis.",
"Between 1991 and 1996, 30 447 subjects (18 326 women) were included in a community-based health survey. Information on femal... | RA was predicted by an early age at menopause. This implicates an influence of hormonal changes during the fertile period on the development of RA in postmenopausal women. | yes |
9,158,073 | Do climacteric symptoms impair cognitive performances in postmenopause? | {
"contexts": [
"To investigate whether information processing and attention performances are affected by climacteric vasomotor symptoms.",
"The study group comprised 66 healthy hysterectomized postmenopausal women. The subjects were divided into two subgroups (high symptomatic and low symptomatic) according ... | Despite subjective complaints of memory impairment in association with climacteric vasomotor symptoms, our results did not support a direct cause-and-effect relationship. Thus, the minor deficits found in cognitive processing efficiency seem to be related rather to age than climacteric symptoms. | no |
17,412,519 | Is postmenopause associated with recurrence of differentiated papillary thyroid carcinoma? | {
"contexts": [
"Differentiated papillary thyroid carcinoma (D-PTC) is the most common malignancy arising in the thyroid gland. There are gender differences in the incidence of PTC being mainly observed in females. Low-risk groups consisted of men younger than 40-year-old and women younger than 50-year-old, where... | Postmenopause is an adverse factor for tumor evolution in women with D-PTC and is associated with EGFR expression. It's introduction in thyroid tumor stratification could be a fine tuning in predicting papillary thyroid carcinoma behavior. | yes |
20,444,912 | Does estrogen deficiency after menopause result in male very-low-density lipoprotein metabolism phenotype? | {
"contexts": [
"Sex differences in lipid metabolism result in a less proatherogenic plasma lipid profile in premenopausal women than men. The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women.",
"Our objective was to evaluate t... | Endogenous ovarian sex steroids are responsible for sexual dimorphism in VLDL-TG secretion, whereas VLDL-apoB-100 secretion is not regulated by female reproductive hormones. | no |
9,236,807 | Do women with past history of bone fracture have low spinal bone density before menopause? | {
"contexts": [
"Recent work from our laboratory has demonstrated that young girls with bone fractures have low spinal bone density more often than girls who have never fractured. This study was undertaken to determine whether adult women approaching menopause who have any past history of fracture have lower spin... | We conclude that women who report a previous history of fracture, either as young adults or in childhood, should be targeted for perimenopausal screening for osteoporosis since they are likely to have lower bone density and a greater risk of future fracture than women with no past history of fracture. | yes |
12,009,354 | Is a low number of retrieved oocytes at in vitro fertilization treatment predictive of early menopause? | {
"contexts": [
"To investigate whether women with a low number of retrieved oocytes at the first in vitro fertilization (IVF) attempt have an increased risk of early menopause.",
"Nested case-control study.",
"Twelve IVF clinics in the Netherlands.",
"Women participating in a nationwide Dutch cohort ... | These results suggest that women with a low number of retrieved oocytes at the first IVF treatment are more likely to become postmenopausal at an early age than women with a higher number of retrieved oocytes. Our study is the first longitudinal study to provide strong evidence for the quantitative aspect of the ovaria... | yes |
22,537,818 | Are polymorphisms in adiposity-related genes associated with age at menarche and menopause in breast cancer patients and healthy women? | {
"contexts": [
"Is there any effect of genetic polymorphisms in adiposity-related genes on the timing of menarche and menopause and the total duration of menstruation among Korean women?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adiposity",
"Adolescent",
"Adult",
"Aged",
"Breast... | Our results suggest that the adiposity-related genes LEP, LEPR and PPARγ may play a role in the onset and cessation of menstruation, and the total duration of menstruation. | yes |
23,374,709 | Is low BMD an independent predictor of fracture and early menopause of mortality in post-menopausal women -- a 34-year prospective study? | {
"contexts": [
"Identify risk factors for fragility fractures and mortality in women aged 48.",
"Prospective population-based observational study on 390 white north European women aged 48 at study start. At study start, we measured bone mineral density (BMD) by single-photon absorptiometry (SPA) in the dista... | Low BMD at age 48 is an independent predictor for fragility fractures. The predictive ability of early menopause is at least partially attributed to other associated risk factors. Early menopause and smoking were found in this study to be independent predictors for mortality. | yes |
20,309,677 | Is years from menopause-to-surgery a major factor in the post-operative subjective outcome for pelvic organ prolapse? | {
"contexts": [
"The purpose of the current study was to determine the main factors associated with post-operative subjective outcome in post-menopausal patients with pelvic organ prolapse.",
"Ninety-four women were selected among patients who underwent surgery for grade 3 or 4 prolapse. The outcome was evalu... | The greater the number of years from menopause-to-pelvic organ prolapse surgery, the less satisfied were the patients. The association between older patients and greater satisfaction appears to be a confounding effect of prolapse grade. | yes |
16,794,486 | Does angiotensin II induce vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension? | {
"contexts": [
"Follitropin-receptor knockout (FORKO) mice are estrogen-deficient, hyperandrogenic and exhibit features of menopause and elevated blood pressure (BP). Because the renin-angiotensin system has been implicated in menopause-associated hypertension, we questioned whether angiotensin II (Ang II) chall... | Thus, in FORKO mice Ang II exacerbates endothelial dysfunction, augments contractility, increases oxidative stress, and promotes cardiac fibrosis without worsening vascular remodeling or BP elevation compared to Ang II-treated WT controls. Our findings suggest that in FORKO mice Ang II may be more important in influenc... | yes |
25,137,243 | Does low-dose paroxetine ( 7.5 mg ) improve sleep in women with vasomotor symptoms associated with menopause? | {
"contexts": [
"Sleep disturbances are common among women in midlife; prevalence increases among perimenopausal/postmenopausal women with vasomotor symptoms. Paroxetine 7.5 mg is the only nonhormonal treatment that has been approved in the United States for moderate to severe vasomotor symptoms associated with m... | In postmenopausal women treated for menopausal vasomotor symptoms, paroxetine 7.5 mg significantly reduces the number of nighttime awakenings attributed to vasomotor symptoms and increases sleep duration without differentially affecting sleep-onset latency or sedation. | yes |
27,801,704 | Does vertical sleeve gastrectomy improve indices of metabolic disease in rodent model of surgical menopause? | {
"contexts": [
"Although women are the most common recipients of weight loss surgeries for the amelioration of the comorbidities of obesity, few studies have addressed the efficacy of these procedures with specific attention to reproductive stage. Here we ask in a rodent model of vertical sleeve gastrectomy (VSG... | Taken together, VSG in OVX rats experience many positive benefits including the resolution of hepatic steatosis that persists in reproductively intact female rats after VSG. | yes |
18,600,211 | Does menopause not aldosterone-to-renin ratio predict blood pressure response to a mineralocorticoid receptor antagonist in primary care hypertensive patients? | {
"contexts": [
"It has been suggested that hypertensive patients with raised aldosterone-to-renin ratio (ARR) are specifically sensitive to mineralocorticoid receptor antagonists (MRAs). We have previously shown that patients with an elevated ARR are relatively frequent in the setting of primary care. We therefo... | These results suggest that postmenopausal hypertension is largely dependent on mineralocorticoid receptor activation and selectively sensitive to MRAs. | yes |
18,178,196 | Do follicle-stimulating hormone receptor and DAZL gene polymorphisms affect the age of menopause? | {
"contexts": [
"To evaluate whether single nucleotide FSH receptor and DAZL gene polymorphisms are associated with menarche and menopause timing.",
"Prospective study.",
"Siena and Münster Universities.",
"Physiologically menopausal women.",
"The presence of FSH receptor or DAZL gene polymorphism... | We found that genotype of FSH receptor or SNP of DAZL do not predict the age at natural menopause and duration of fertility in women. The presence of Asn680/Asn680 genotype is associated with a slightly delayed age at menarche. | no |
18,177,456 | Is hormonal replacement therapy after menopause protective of disease activity in women with inflammatory bowel disease? | {
"contexts": [
"The nature of inflammatory bowel disease (IBD) following menopause has not been previously studied. The aim of this study was to characterize the effect of menopause on disease activity and identify possible modifiers of disease activity.",
"This was a retrospective study of women followed at... | The likelihood of having a flare postmenopause is not different from having it premenopause. HRT, however, may provide a protective effect for disease activity in the postmenopausal period. The anti-inflammatory effects of estrogen may be the mechanism for this observation. | yes |
12,939,416 | Is seizure frequency associated with age at menopause in women with epilepsy? | {
"contexts": [
"To determine whether the age at menopause in women with epilepsy is associated with seizure frequency.",
"Women with epilepsy ages 45 and older from urban epilepsy centers were surveyed by interview and chart review for reproductive and general health characteristics, as well as seizure histo... | Seizure frequency or lifetime number of seizures is associated with the timing of cessation of reproductive cycling. Seizures may disrupt hypothalamic and pituitary function or alter neurally mediated trophic effects on the ovary. | yes |
26,778,586 | Does early menopause influence left ventricular diastolic dysfunction : A clinical observational study in healthy subjects? | {
"contexts": [
"The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women after their 50s and may contribute to the high prevalence of diastolic heart failure in elderly women. A decrease in estrogen levels after menopause is postulated to be one of the mechanisms responsible for... | Early menopause did not influence the progression of LVDD in postmenopausal women. The sharp progression of LVDD in elderly women is complex and probably influenced by multiple factors. | no |
19,194,113 | Are estradiol and testosterone levels lower after oophorectomy than after natural menopause? | {
"contexts": [
"The aim of this study was to compare hormone levels between women who became postmenopausal after a prophylactic bilateral salpingo-oophorectomy, and women who became postmenopausal in a natural way.",
"In this cross-sectional study, we investigated estradiol, testosterone, SHBG, IGF-1 and IG... | For IGF-1, IGFBP-3 and SHBG, no differences were found between surgically and naturally postmenopausal women. Lower estradiol levels of surgically as compared to naturally postmenopausal women seem to be fully explained by the earlier onset of menopause in combination with the same age-related decrease. However, a decr... | yes |
17,852,142 | Does menopause alter the metabolism of serum serotonin precursors and their correlation with gonadotropins and estradiol? | {
"contexts": [
"Tryptophan, the serotonin (5-HT) precursor, is circulating in blood in both free (FT) and protein-bound forms. The free form crosses the hematoencephalic barrier and is converted into 5-HT. During the fertile years, tryptophan levels are negatively correlated to gonadotropin concentrations. The p... | High TT levels circulate in postmenopausal women, with lack of correlation between TT and FT, and FT/TT and gonadotropins. Since estrogens play a pivotal role on central 5-HT metabolism, estrogen deprivation may alter the brain tryptophan utilization for 5-HT synthesis and its relation to gonadotropin release. | yes |
20,061,896 | Is aLOX12 gene associated with the onset of natural menopause in white women? | {
"contexts": [
"Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complet... | The ALOX12 gene seems to be associated with the timing of natural menopause in white women. | yes |
18,202,962 | Have life prevalence of hormone replacement therapy and profile of users changed among women with self-reported menopause in the last two decades in Porto , Portugal? | {
"contexts": [
"To describe the prevalence of hormone replacement therapy (HRT) in a Portuguese population by menopause date, from 1985 to 2005.",
"Participants were 382 postmenopausal women assessed as part of the ongoing follow-up evaluation of a cohort of Portuguese adults. Data were collected on educatio... | The prevalence of use of HRT and characteristics of users among Portuguese women living in Porto and entering menopause in the last 20 years have not changed substantially. | no |
17,213,751 | Is menopause , but not age , an independent risk factor for fasting plasma glucose levels in nondiabetic women? | {
"contexts": [
"Glucose metabolism is influenced by various genetic and environmental factors. In women the prevalence of abnormal glucose metabolism is known to increase around and after age 50. The aim of this study was to determine whether menopause augments fasting plasma glucose (FPG) levels in women.",
... | Menopause, but not age, is directly involved in augmented FPG levels in nondiabetic women. | yes |
19,387,417 | Are type 2 diabetes mellitus and other cardiovascular risk factors no more common during menopause : longitudinal study? | {
"contexts": [
"The aim of this study was to undertake a prospective study of the changes in certain risk factors for cardiovascular disease occurring during menopause.",
"A longitudinal cohort study of 475 women was followed up for 6 years (Pizarra Study). The final menstrual period was defined after at lea... | Menopause is a biological condition of the human species, for which has recently received attempts at medicalization that were not always justified. If menopause is not accompanied by any other cardiovascular risk factor independently of age, the stigma of menopause being considered a risk factor should cease. Although... | yes |
10,458,225 | Do adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis? | {
"contexts": [
"Weight gain is common during the first year after breast cancer diagnosis. In this study, we examined clinical factors associated with body size at diagnosis and weight gain during the subsequent year.",
"An inception cohort of 535 women with newly diagnosed locoregional breast cancer underwe... | Weight gain is common after breast cancer diagnosis; use of adjuvant chemotherapy and onset of menopause are the strongest clinical predictors of this weight gain. | yes |
20,531,232 | Are tNFRSF11A and TNFSF11 associated with age at menarche and natural menopause in white women? | {
"contexts": [
"Menarche and menopause mark the lower and upper limits of the female reproductive period. The timing of these events influences women's health in later life. The onsets of menarche and menopause have a strong genetic basis. We tested two genes, TNFRSF11A (RANK) and TNFSF11 (RANKL), for their asso... | The TNFRSF11A and TNFSF11 genes are associated with the onset of AM and ANM in white women. | yes |
15,205,567 | Is body mass index but not a polymorphism of the interleukin-1 receptor antagonist ( IL-1 RA ) gene associated with age at natural menopause? | {
"contexts": [
"A genetic component of the onset of menopause has been described and several candidate genes have been identified. We hypothesized that carriage of a polymorphism of the interleukin-1 receptor antagonist gene (IL-1 RA) is associated with an early age at menopause.",
"In a prospective cohort s... | Our preliminary data suggest that an 86-base pair tandem repeat polymorphism in intron 2 of IL-1 RA does not modulate the onset and cessation of menses in this cohort of Caucasian women. | yes |
14,757,274 | Is menometrorrhagia in the perimenopause associated with increased serum estradiol? | {
"contexts": [
"The purpose of this study was to evaluate the possible association between menometrorrhagia and the level of endogenous estrogen in perimenopausal women.",
"A prospective controlled study in which 28 perimenopausal women > 40 years presenting with menometrorrhagia were compared with 28 age-ma... | An association between a high endogenous estradiol level and menometrorrhagia in the perimenopause was demonstrated. This may have implications for the choice of treatment in this group of women. It is proposed that this type of bleeding disturbances should be controlled by progestins only, and not with combined estrog... | yes |
14,757,272 | Does menopause induced by oophorectomy reveal a role of ovarian estrogen on the maintenance of pressure homeostasis? | {
"contexts": [
"Following spontaneous menopause women show a greater increase in systolic and diastolic blood pressure than men of the same age. The aim of the present study was to assess the effect of acute ovarian hormone withdrawal and replacement on blood pressure and forearm blood flow.",
"We studied 18... | Surgically-induced menopause causes an increase in peripheral vascular resistance and blood pressure suggesting a role of ovarian hormones in the homeostatic pressure modulation. Recovery of the baseline condition after ERT suggests that the accelerated increase in blood pressure after menopause is due to ovarian and a... | yes |
22,310,107 | Are gene variants in PPARD and PPARGC1A associated with timing of natural menopause in the general Japanese population? | {
"contexts": [
"Timing of menopause affects postmenopausal health risks. The objective of this study was to evaluate the associations of the single nucleotide polymorphisms (SNPs) in peroxisome proliferator-activated receptor (PPAR)-related genes (PPARD, PPARG, and PPARGC1A) and environmental factors with timing... | Gene variants in PPARD and PPARGC1A might be associated with timing of natural menopause, probably through direct actions on the ovaries, among the general Japanese population. | yes |
16,126,796 | Are early menopause , low body mass index , and smoking independent risk factors for developing giant cell arteritis? | {
"contexts": [
"To assess female sex hormone related variables in a group of women with biopsy positive giant cell arteritis and a control group.",
"49 women with biopsy positive giant cell arteritis, aged 50 to 69 years at the time of diagnosis, answered a questionnaire on hormonal and reproductive factors.... | There was a significant association between hormonal and reproduction related factors and the risk of developing giant cell arteritis in women given the diagnosis before the age of 70. The results suggest a possible role of oestrogen deficiency in the pathogenesis of giant cell arteritis. To confirm the results, an ext... | yes |
22,969,140 | Is endothelial function impaired across the stages of the menopause transition in healthy women? | {
"contexts": [
"The stages of the menopause transition are characterized by changes in ovarian hormones and increased cardiovascular disease (CVD) risk factors and vasomotor symptoms that may adversely affect vascular health.",
"We tested the hypothesis that endothelial function, a predictor of CVD, would be... | Our findings suggest that a decline in endothelial function begins during the early stages of menopause (perimenopause) and worsens with the loss of ovarian function and prolonged estrogen deficiency. These data add to the accumulating evidence that the perimenopausal window is a critical time period for adverse change... | yes |
9,032,743 | Are alcohol consumption and age of maternal menopause associated with menopause onset? | {
"contexts": [
"To examine whether a number of nutritional and familial factors were associated with menopausal development.",
"A prospective postal survey amongst a random sample of 1227 women aged 47 to 51 who were premenopausal in a cross-sectional survey 2 years previously. Women were classed into three ... | These results suggest that, (1) there is a strong familial association in menopausal age, and (2) moderate consumption of alcohol is associated with delayed menopausal development. | yes |
19,225,427 | Is a single test of antimullerian hormone in late reproductive-aged women a good predictor of menopause? | {
"contexts": [
"The aim of this study was to assess the capability of a single measurement of antimullerian hormone (AMH) to predict menopause status in late reproductive-aged women.",
"A group of 147 women, naturally fertile, aged 40 to 50 years with regular menstrual cycles were selected from the Tehran Li... | Of every 10 women in late reproductive age with AMH levels greater than 0.39 ng/mL, only one will reach menopause status within the next 6 years. A single AMH measurement is a good predictor for the onset of menopause. | yes |
25,761,872 | Does surgical menopause initiate molecular changes that do not result in mechanical changes in normal and healing ligaments? | {
"contexts": [
"Ligaments which heal spontaneously have a healing process that is similar to skin wound healing. Menopause impairs skin wound healing and may likewise impair ligament healing. Our purpose in this study was to investigate the effect of surgical menopause on ligament healing in a rabbit medial coll... | Surgical menopause did not affect the mechanical properties of normal or early healing medial collateral ligaments in a rabbit model. The results in this preclinical model suggest that menopause may result in no further impairment to the ligament healing process. Cite this article: Bone Joint Res 2015;4:38-44. | yes |
21,946,090 | Does meta-analysis suggest that smoking is associated with an increased risk of early natural menopause? | {
"contexts": [
"Age at natural menopause (ANM) is usually defined as the age at the last menstrual bleeding followed by the absence of menses for 12 consecutive months. Although many studies have suggested an association between smoking and early age at natural menopause, evidence remains conflicting because som... | The results of our study suggest that smoking is a significant independent factor for early ANM. | yes |
18,373,052 | Does bone mineral density at menopause predict breast cancer incidence? | {
"contexts": [
"In this prospective study in 2,137 perimenopausal and early postmenopausal women who were followed over a 13.1-year period of time, we observed no association between bone mineral density measured at the beginning of menopause and the subsequent risk of breast cancer.",
"This study aimed to i... | There was no relationship between BMD measured within the first postmenopausal years and the risk of BC, which makes unlikely the possibility of using BMD as a predictor factor for BC in early postmenopausal women. | no |
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