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0-dimensional biomaterials lack inductive properties.
Rising temperatures caused by global warming increases risk of dengue fever transmission.
[ "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Repressi...
[ "0-dimensional biomaterials lack inductive properties.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Myelin sheaths are lipid-rich cellular structures.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Mitochondria play a...
0-dimensional biomaterials lack inductive properties.
2
1 in 5 million in UK have abnormal PrP positivity.
Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.
[ "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "5'-nucleotidase metabolizes 6MP.", "...
[ "1 in 5 million in UK have abnormal PrP positivity.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Sepsis related mortality has rise...
1 in 5 million in UK have abnormal PrP positivity.
4
1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.
Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.
[ "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "KRT17 modulates the expression of the...
[ "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Bariatric surgery reduces colorectal cancer.", ...
61% of colorectal cancer patients are diagnosed with regional or distant metastases.
6
10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.
Distant CREs are less conserved among species.
[ "Distant CREs are less conserved among species.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "1 in 5 million ...
[ "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is hig...
10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.
9
32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.
Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.
[ "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "TNFAIP3 i...
[ "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "CRP is positively correlated with ...
32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.
10
4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.
Bacteriophagaes MS2 and Qβ are members of the Leviviridae.
[ "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Ly6C hi m...
[ "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "CHOP is a general endoplasmic reticulum stress marker.", "BiP is a general...
4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.
11
4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.
L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.
[ "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "The remov...
[ "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "CHOP is a general endoplasmic reticulum stress marker.", "BiP is a general...
4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.
12
40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.
Distant CREs are important for transcriptional regulation.
[ "Distant CREs are important for transcriptional regulation.", "Insulin effects appetite via ventral tegmental neurons.", "Depletion of nitric oxide is responsible for vasospasm.", "ART has no effect on the infectiveness of HIV-positive people.", "CRP is positively correlated with postoperative mortality fol...
[ "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", ...
40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.
14
5'-nucleotidase metabolizes 6MP.
Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
[ "Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Increased flux of microbial products provokes immune responses.", "Helminths interfere with immune system control of coinfections by microbial pathog...
[ "5'-nucleotidase metabolizes 6MP.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln ...
5'-nucleotidase metabolizes 6MP.
15
50% of patients exposed to radiation have activated markers of mesenchymal stem cells.
The minor G allele of FOXO3 up-regulates IL-10.
[ "The minor G allele of FOXO3 up-regulates IL-10.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Removal of H3K9me3 by ectopic expres...
[ "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "1-1% of colorectal cancer pa...
50% of patients exposed to radiation have activated markers of mesenchymal stem cells.
17
53% of perinatal mortality is due to low birth weight.
Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.
[ "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "90% of sudden infant death syndrome (SIDS) deaths happen in...
[ "53% of perinatal mortality is due to low birth weight.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Birth-weight is negatively associated with breast cancer.", "10% of sudden infant death synd...
53% of perinatal mortality is due to low birth weight.
18
61% of colorectal cancer patients are diagnosed with regional or distant metastases.
Adult tissue-resident macrophages are seeded before birth.
[ "Adult tissue-resident macrophages are seeded before birth.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Folate and vitamin B12 levels influence the association between homocystei...
[ "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Bariatric surgery reduces colorectal cancer.", ...
61% of colorectal cancer patients are diagnosed with regional or distant metastases.
19
7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.
B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.
[ "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "The World Health Organization's (WHO) data collection process is biased downward by ...
[ "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Individuals with Alzheimers who participate in six months of physical acti...
7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.
20
7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.
Pioglitazone use is not associated with an increased risk of prostate cancer.
[ "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial...
[ "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Individuals with Alzheimers who participate in six months of physical acti...
7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.
21
70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.
Pseudoknots are not evolutionarily conserved in most eukaryotes.
[ "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Angiotensin converting enzyme inhibitors ...
[ "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Pati...
70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.
22
76-85% of people with severe mental disorder receive no treatment in low and middle income countries.
The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
[ "The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Hypocretin neurones suppress panicprone state in rats.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative str...
[ "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "The mean suicide rate in women is higher after miscarriage than live birth.", ...
76-85% of people with severe mental disorder receive no treatment in low and middle income countries.
24
90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.
Cognitive behavioral therapy is an ineffective treatment for insomnia
[ "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Pre-mRNAs associated w...
[ "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Side effects associated with antidepressants increases risk of stroke.", "The most prevalent adver...
90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.
25
90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.
Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.
[ "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inacti...
[ "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is hig...
90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.
26
A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.
Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.
[ "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Glial calcium waves influence seizures.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules."...
[ "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared...
A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.
27
A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.
YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.
[ "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paire...
[ "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared...
A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.
28
A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).
[ "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Ethanol stress lowers the expression of PSP in bacteria.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "BLM gene encodes RecQ-class DNA helicase.", "Active Ly49Q prevents neutrophil po...
[ "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Reduced respon...
A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
30
A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.
A deficiency of vitamin B6 decreases blood levels of homocysteine.
[ "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Inside the body, falciparum parasites reproduce asexually.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease i...
[ "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Sildenafil worsens erectile function in men who experience se...
A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.
32
A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.
There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.
[ "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing sub...
[ "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "The World Health Organization's (WHO) data collection process is biased downward by u...
A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.
34
A deficiency of folate increases blood levels of homocysteine.
Piezo1 channels are sensors for cell migration in epithelial cells.
[ "Piezo1 channels are sensors for cell migration in epithelial cells.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "The NF-κB essential modulator g...
[ "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Intake of folic ac...
A deficiency of folate increases blood levels of homocysteine.
35
A deficiency of vitamin B12 decreases blood levels of homocysteine.
The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.
[ "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "miR-142-5P is a known regulator of raised body temperature.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "The predominant localization...
[ "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Int...
A deficiency of vitamin B12 decreases blood levels of homocysteine.
37
A deficiency of vitamin B6 decreases blood levels of homocysteine.
Increased flux of microbial products provokes immune responses.
[ "Increased flux of microbial products provokes immune responses.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "KLF4 is necessary for ...
[ "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Intake of folic ...
A deficiency of vitamin B6 decreases blood levels of homocysteine.
39
A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.
V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.
[ "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Increased microtubule acetyl...
[ "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infer...
A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.
40
A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.
Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.
[ "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomo...
[ "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infer...
A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.
41
A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.
50% of patients exposed to radiation have activated markers of mesenchymal stem cells.
[ "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Adult tissue-resident macrophages are seeded before birth.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Diabetic patients with acute coronary syndrome experience decreased shor...
[ "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "HbA1c consistently overestimates glycemic control i...
A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.
43
A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.
Pyridostatin decreases telomere fragility in BRCA2-deficient cells.
[ "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are n...
[ "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "The HSV-2 infection is typically asymptomatic.", "Perigenital skin is not the primary site of HIV acquisition.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "The latent ...
A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.
44
A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.
Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.
[ "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Lack of FGF21 in mice leads to atherosclerotic plaq...
[ "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", ...
A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.
45
A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.
Localization of PIN1 in the roots of Arabidopsis requires VPS9a
[ "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Active H. pylori urease has a polymeric structure consisting of five distinct sub...
[ "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", ...
A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.
46
A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
The risk of cancer rises with level of alcohol consumption.
[ "The risk of cancer rises with level of alcohol consumption.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "APOE4 expression in iPSC-derived neurons results in decrease...
[ "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "HNF4A mutations are associated with macrosomia in infancy.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype ...
A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
47
A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.
Cardiac tissue-resident macrophages directly contribute to electrical activity.
[ "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammat...
[ "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Interferon stimulated ge...
A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.
52
ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.
The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.
[ "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Rapamycin increases the concentration of triacylglycerols in fruit fli...
[ "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Normal expression of RUNX1 causes tumorsupressing effects.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a glioblastoma tumor suppressor.", "BRCA 1 mutati...
ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.
55
AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.
Prescribed exercise training improves quality of life.
[ "Prescribed exercise training improves quality of life.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Transplan...
[ "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Cancer-associated fibroblasts (CAFs) intera...
AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.
58
APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.
Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.
[ "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with ...
[ "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Converting apoE4 to apoE3 by gene editing worsens the patho...
APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.
60
ART has no effect on the infectiveness of HIV-positive people.
Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.
[ "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Self-advocacy training is effective at decreasing homelessness.", "Pyridostatin deregulates G2/M progression....
[ "ART has no effect on the infectiveness of HIV-positive people.", "ART substantially reduces infectiveness of HIV-positive people.", "Having a main partner worsens HIV outcomes.", "Perigenital skin is not the primary site of HIV acquisition.", "Patients in stable partnerships have a slower progression from ...
ART has no effect on the infectiveness of HIV-positive people.
61
ART substantially reduces infectiveness of HIV-positive people.
A deficiency of vitamin B6 decreases blood levels of homocysteine.
[ "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "In breast cancer, the loss of myoepithelial cells pr...
[ "ART substantially reduces infectiveness of HIV-positive people.", "ART has no effect on the infectiveness of HIV-positive people.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Perigenit...
ART substantially reduces infectiveness of HIV-positive people.
62
ATF4 is a general endoplasmic reticulum stress marker.
The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
[ "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "The minor G allele of FOXO3 up...
[ "ATF4 is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "CHOP is a general endoplasmic reticulum stress marker.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment...
ATF4 is a general endoplasmic reticulum stress marker.
63
ATM and Rad3 related protein are critical for sensing DNA damage.
Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.
[ "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Immune response...
[ "ATM and Rad3 related protein are critical for sensing DNA damage.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Activated Cdk5...
ATM and Rad3 related protein are critical for sensing DNA damage.
64
ATM and Rad3 related protein have no role in sensing DNA damage.
Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.
[ "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Cnn1 recruitment varies with cell cycle timing.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraven...
[ "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Activated Cdk5...
ATM and Rad3 related protein have no role in sensing DNA damage.
66
AZT given with ribavirin increases anemia.
Physical activity does not improve cognitive function in individuals with Alzheimers.
[ "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Upregulation of PD1 causes the downmodulation of Satb1.", "KRT...
[ "AZT given with ribavirin increases anemia.", "Antidepressants increase the severity of migraines.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Antidepressants reduce the sev...
AZT given with ribavirin increases anemia.
67
Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.
Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.
[ "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Prescribed exercise training improves quality of life.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", ...
[ "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein...
Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.
68
Activated Cdk5 regulates DNA damage-induced neuronal death.
Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.
[ "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "HOXB4 is a highly expressed compo...
[ "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "FoxO3a ac...
Activated Cdk5 regulates DNA damage-induced neuronal death.
69
Activation of PPM1D enhances p53 function.
Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.
[ "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "β1/Ketel is able to bind microtubules.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "In S. cerevisiae, t...
[ "Activation of PPM1D enhances p53 function.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Up-regulation of the p53 pathway and re...
Activation of PPM1D enhances p53 function.
71
Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.
N348I mutations reduce resistance to nevirapine.
[ "N348I mutations reduce resistance to nevirapine.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "COPI coatmer is involved in lipid homeostasis.", "Depletion of nitric oxide is responsible for vasospasm.", "Homozygous deletion of murine Sb...
[ "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Activation of PPM1D enhances p53 function.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "The Snf1 complex regulate...
Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.
73
Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.
HAND2 methylation is a key step in early endometrial carcinogenesis.
[ "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Pro-inflammatory cytokines...
[ "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", ...
Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.
74
Active H. pylori urease has a polymeric structure consisting of five distinct subunits.
ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.
[ "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Higher plasma levels of I-carnitine,...
[ "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "The composition of myosin-II isoform switches from the A isoform to the B isoform d...
Active H. pylori urease has a polymeric structure consisting of five distinct subunits.
76
Active Ly49Q induces neutrophil polarization.
Having a main partner improves HIV outcomes.
[ "Having a main partner improves HIV outcomes.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Cnn1 recruitment varies with cell cycle timing.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "The amount of pu...
[ "Active Ly49Q induces neutrophil polarization.", "Active Ly49Q prevents neutrophil polarization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Blocking the interaction between TDP-43 and respirator...
Active Ly49Q induces neutrophil polarization.
77
Active Ly49Q prevents neutrophil polarization.
NAC destabilizes NO to increase the effect of contrast agents on renal functions.
[ "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "There is no increased risk of hypospadias with clomiphene.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Chinese individuals with TT homozygosity in the MTHFR gene are...
[ "Active Ly49Q prevents neutrophil polarization.", "Active Ly49Q induces neutrophil polarization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced...
Active Ly49Q prevents neutrophil polarization.
78
Active caspase-11 participate in regulating phagosome-lysosome fusion.
Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.
[ "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Long chain polyunsaturated fatty acids supplementati...
[ "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Active caspase-11 protein promotes pyroptosis.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Comparative transcriptom...
Active caspase-11 participate in regulating phagosome-lysosome fusion.
79
Active caspase-11 protein promotes pyroptosis.
In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.
[ "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Pro-i...
[ "Active caspase-11 protein promotes pyroptosis.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "H4 G94P proteins induce ...
Active caspase-11 protein promotes pyroptosis.
80
Acute ablation of KRAS causes severe growth impairment.
Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.
[ "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Nigerian physicians constitue the largest comp...
[ "Acute ablation of KRAS causes severe growth impairment.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-Ra...
Acute ablation of KRAS causes severe growth impairment.
81
Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.
Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.
[ "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Tonic sign...
[ "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "MeCP2 influences the synaptic maturation of neur...
Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.
82
Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)
Bariatric surgery reduces postmenopausal breast cancer.
[ "Bariatric surgery reduces postmenopausal breast cancer.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively ...
[ "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Fibroblast growth factor 21 protects against atherosclerosis by modu...
Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)
85
Adult tissue-resident macrophages are seeded before birth.
HNF4A mutations are associated with macrosomia in infancy.
[ "HNF4A mutations are associated with macrosomia in infancy.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Input from mental and physical health care professionals is not effective at decreasing homelessness.", "Chenodeoxycholic acid treatment increases brown ad...
[ "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident mac...
Adult tissue-resident macrophages are seeded before birth.
86
Adult tissue-resident macrophages are seeded before birth.
Gastric lavage is an effective treatment for acute paraquat poisoning.
[ "Gastric lavage is an effective treatment for acute paraquat poisoning.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from t...
[ "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident mac...
Adult tissue-resident macrophages are seeded before birth.
88
Adult tissue-resident macrophages possess a self-renewing capacity.
For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.
[ "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Klf4 is not required for proper myeloid cell differentiation.", "...
[ "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident mac...
Adult tissue-resident macrophages possess a self-renewing capacity.
89
Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.
The innate immune response struggles to remove small numbers of parasites.
[ "The innate immune response struggles to remove small numbers of parasites.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Mathematical models predict that using Artemisinin...
[ "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "...
Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.
90
Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.
Participants who quit smoking reduce lung cancer risk by approximately 50%.
[ "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "CCL19 is a ligand for CCR7.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and impr...
[ "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "...
Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.
91
Aged patients are less susceptible to ischaemia/reperfusion injury.
cSMAC formation represses weak ligand signalling.
[ "cSMAC formation represses weak ligand signalling.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Cnn1 recruitment varies with cell cycle timing.", "Intramembrane cleavage by signal peptide peptidase aids in the deg...
[ "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Diabetic patients with acute coronary syndrome exper...
Aged patients are less susceptible to ischaemia/reperfusion injury.
92
Aged patients are more susceptible to ischaemia/reperfusion injury.
Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.
[ "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Kir7.1 modulates channel activity by the G protein-coupled melanocorti...
[ "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Nonhypertensive people who are 55 years old h...
Aged patients are more susceptible to ischaemia/reperfusion injury.
93
Aggravated inflammation is dependent on NLRP3 inflammasome activation.
Adult tissue-resident macrophages are seeded before birth.
[ "Adult tissue-resident macrophages are seeded before birth.", "Sn is present on mature DCs during inflammation in vivo.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Nonhuman primate...
[ "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "The NF-κB essential modula...
Aggravated inflammation is dependent on NLRP3 inflammasome activation.
95
Albendazole is used to treat soil-transmitted helminths.
Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.
[ "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "The one-child policy has created a hospitable environment for female infants.", "The DESMOND program ...
[ "Albendazole is used to treat soil-transmitted helminths.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria trans...
Albendazole is used to treat soil-transmitted helminths.
96
Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.
Upregulation of PD1 causes the upregulation of Satb1.
[ "Upregulation of PD1 causes the upregulation of Satb1.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "The effect of Lipopolysaccharides on kidney barrier function is depende...
[ "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Students who perform poorly in the early years of medical school are less l...
Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.
98
Alirocumab treatment reduces apo(a) fractional clearance rate.
Prescribed exercise training improves quality of life.
[ "Prescribed exercise training improves quality of life.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ l...
[ "Alirocumab treatment reduces apo(a) fractional clearance rate.", "AZT given with ribavirin increases anemia.", "Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "The mo...
Alirocumab treatment reduces apo(a) fractional clearance rate.
104
Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.
At least 85% of patients exposed to radiation have activated markers of myofibroblasts.
[ "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalia...
[ "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Sudden death can occur in patien...
Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.
105
Alteration of origin firing causes changes in termination zones of Okazaki fragments.
PCSK9 inhibitors decrease plasma Lp(a) levels.
[ "PCSK9 inhibitors decrease plasma Lp(a) levels.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Klf2 is important for proper myeloid cell function.", "Kir7.1 modulates channel activity by the G p...
[ "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Acute ablation of Snail in the em...
Alteration of origin firing causes changes in termination zones of Okazaki fragments.
106
Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.
BLM gene encodes RecQ-class DNA helicase.
[ "BLM gene encodes RecQ-class DNA helicase.", "Antidepressants increase the severity of migraines.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "RUNX is not expressed in skin tissue.", "Egr2 regulates the homeostasis of B and T cells.", "Adult tis...
[ "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Sudden death can occur in patients with orthost...
Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.
108
Amitriptyline is an effective treatment for chronic tension-type headaches.
Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.
[ "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes...
[ "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressan...
Amitriptyline is an effective treatment for chronic tension-type headaches.
109
An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.
Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.
[ "Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Diabetes remission occurs...
[ "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy...
An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.
111
Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.
Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).
[ "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptid...
[ "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from all th...
Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.
112
Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
The innate immune response struggles to remove small numbers of parasites.
[ "The innate immune response struggles to remove small numbers of parasites.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Deletion of ATM and Rad3 relat...
[ "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) pr...
Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
114
Anthrax spores are very difficult to dispose once they are dispersed.
Cellular clocks are associated with mitosis timing in NIH 3T3 cells.
[ "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "PKG-la does...
[ "Anthrax spores are very difficult to dispose once they are dispersed.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The tissue surrounding the granuloma in an immun...
Anthrax spores are very difficult to dispose once they are dispersed.
116
Anthrax spores remain deadly until affected areas are decontaminated.
RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.
[ "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Pyridostatin induces checkpoint activation.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Omnivores prod...
[ "Anthrax spores remain deadly until affected areas are decontaminated.", "Anthrax spores are very difficult to dispose once they are dispersed.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Charcoal is an effective treatment for acu...
Anthrax spores remain deadly until affected areas are decontaminated.
119
Antidepressants increase the severity of migraines.
For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.
[ "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Lack of FGF21 in mice leads to reduced lifespan.", "A deficiency of folate i...
[ "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens...
Antidepressants increase the severity of migraines.
120
Antidepressants reduce the severity of migraines.
Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.
[ "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falcipar...
[ "Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens...
Antidepressants reduce the severity of migraines.
121
Antimicrobial agents are less effective due to the pressure of antimicrobial usage.
Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.
[ "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension."...
[ "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Increased flux of microbial products provokes immune responses.", "Mathematical models predict that using Artemisinin-based combination...
Antimicrobial agents are less effective due to the pressure of antimicrobial usage.
122
Antimicrobial agents are more effective due to the pressure of antimicrobial usage.
32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.
[ "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refract...
[ "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Increased flux of microbial products provokes immune responses.", "Increased flux of microbial products suppresses immune responses.", ...
Antimicrobial agents are more effective due to the pressure of antimicrobial usage.
123
Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.
Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.
[ "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Repressing IL-18 has negative effects on atherosclerotic ...
[ "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modes...
Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.
126
Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.
Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.
[ "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Bacteriophagaes MS2 and Qβ are members of the Leviviridae.", "Systemic lupus erythematosus is a risk factor ...
[ "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Tuberculosis incidence ...
Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.
134
Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.
In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.
[ "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Distant CREs are less conserved among species.", "1-1% of colorectal cancer patients are diagnosed with regional o...
[ "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual ...
Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.
138
Asymptomatic visual impairment screening in elderly populations leads to improved vision.
The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.
[ "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Bone marrow cells don't contribute to adult macrophage compartments.",...
[ "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Headaches are correlated with cognitive impairment.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Individuals with Alzheimers who participate in six months of physical ac...
Asymptomatic visual impairment screening in elderly populations leads to improved vision.
139
At least 85% of patients exposed to radiation have activated markers of myofibroblasts.
Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.
[ "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "The risk of f...
[ "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Cancer-associated fibroblast...
At least 85% of patients exposed to radiation have activated markers of myofibroblasts.
144
Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.
JMJD6 slows the hydroxylation of C-terminal lysine
[ "JMJD6 slows the hydroxylation of C-terminal lysine", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "One in two surgical randomized controlled trials are discontinued early.", "Cognitive behavioral therapy is an ineffective treat...
[ "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Transplanted human glial progenitor cells can mature in their host animal.", ...
Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.
149
Autophagy deficiency in the liver increases vulnerability to insulin resistance.
Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.
[ "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Pyridostatin deregulates G2/M ...
[ "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Insulin decreases risk of severe kidney failure.", "Insulin effects appetite via ventral tegmental neurons.", "Medications to treat obesity have unwanted side effects.", "Medications to treat obesity do not have side effect...
Autophagy deficiency in the liver increases vulnerability to insulin resistance.
152
B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.
RTEL1 interacts with TRF2 through a C4C4 motif
[ "RTEL1 interacts with TRF2 through a C4C4 motif", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcri...
[ "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "Neutrophil...
B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.
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