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Beclin-2 (A8MW95) is a human protein of 431 amino acids with a molecular weight of approximately 48 kDa, functioning as a key regulator in lysosomal degradation pathways. It is involved in both autophagy and the turnover of G-protein coupled receptors (GPCRs), particularly through its interaction with GPRASP1/GASP1, th... |
Apoptosis regulator Bcl-2 (P10415) is a human protein of 239 amino acids with a molecular weight of about 26 kDa, best known for its role in suppressing apoptosis across diverse cell types by regulating mitochondrial membrane permeability and inhibiting caspase activity. Bcl-2 also functions as an inhibitor of autophag... |
Within the interaction network, Beclin-2 and Bcl-2 are strongly linked, with multiple INTERACTS_WITH edges indicating a very high confidence association (confidence score 0.999, dominant source: text mining). This interaction is consistent with the established biological relationship in which Bcl-2 binds to Beclin fami... |
Cell division cycle 7-related protein kinase (CDC7, O00311) is a serine/threonine kinase from Homo sapiens that plays a pivotal role in the initiation of DNA replication. It exerts its function by phosphorylating substrates critical for the G1/S phase transition, including MCM proteins and CLASPIN, thereby regulating t... |
Serine/threonine-protein kinase Chk2 (CHEK2, O96017) is another human kinase, essential for checkpoint-mediated cell cycle arrest, DNA repair, and apoptosis in response to DNA double-strand breaks. CHEK2 phosphorylates a variety of effectors, including CDC25 phosphatases, BRCA2, p53/TP53, and others, thereby orchestrat... |
The interaction network between CDC7 and CHEK2 is strongly supported by experimental evidence, with multiple INTERACTS_WITH edges indicating a high-confidence association (confidence score 0.988). This robust experimental support suggests a functional interplay between these two kinases, potentially linking the regulat... |
Axin-1 (O15169) is a multifunctional scaffold protein in Homo sapiens, with a molecular weight of approximately 95.6 kDa. It plays a central role in the regulation of the Wnt signaling pathway by serving as a core component of the beta-catenin destruction complex, facilitating the phosphorylation and subsequent ubiquit... |
Ubiquitin carboxyl-terminal hydrolase 7 (USP7, Q93009) is a large deubiquitinating enzyme of approximately 128.3 kDa, also from Homo sapiens. USP7 is a hydrolase that removes ubiquitin moieties from a diverse array of substrates, including p53/TP53, MDM2, PTEN, and components of the DNA repair and epigenetic machinery.... |
Within the protein interaction network, Axin-1 and USP7 are experimentally validated to interact with high confidence, as indicated by a confidence score of 0.849. This interaction is supported by multiple experimental sources and is bidirectional in the network, suggesting a robust and potentially functionally signifi... |
Forkhead box protein O3 (FOXO3, accession O43524) is a transcriptional activator from Homo sapiens with a molecular weight of approximately 71 kDa. Its overall architecture is captured in several structural models, including [structure/O43524/alphafold_1.pdb]. FOXO3 is characterized by a central Forkhead (winged-helix)... |
Cellular tumor antigen p53 (TP53, accession P04637) is a multifunctional transcription factor and tumor suppressor with a molecular weight of about 43.6 kDa. Its overall structure is available in several PDB entries, including [structure/P04637/pdb_1A1U.pdb] and [structure/P04637/alphafold_1.pdb]. p53 features a promin... |
The interaction network between FOXO3 and p53 is supported by multiple INTERACTS_WITH edges, each with a very high confidence score of 0.998 and a dominant source of text mining. This strong association suggests a robust functional relationship, consistent with their roles as transcriptional regulators of cell fate. Th... |
Ubiquitin carboxyl-terminal hydrolase 2 (USP2; accession O75604) is a human hydrolase with a molecular weight of approximately 68 kDa, functioning primarily as a deubiquitinating enzyme. It targets polyubiquitinated proteins such as MDM2, MDM4, and CCND1, and plays a significant role in regulating the cell cycle, circa... |
Protein Mdm4 (accession O15151) is a 55 kDa human protein that acts as a negative regulator of the tumor suppressor p53 (TP53). Mdm4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding to their transcriptional activation domains and also prevents the degradation of MDM2, thereby modulating p53 sta... |
The interaction network between USP2 and Mdm4 is supported by experimental evidence, with a high confidence score of 0.819. This interaction is bidirectional and robust, as indicated by multiple edges with consistent confidence values. The network data suggest that USP2 directly deubiquitinates Mdm4, thereby preventing... |
HERC2 (O95714) is a large E3 ubiquitin-protein ligase from Homo sapiens, with a molecular weight of approximately 527 kDa and a length of 4834 amino acids. Its overall architecture is captured in several experimentally determined structures, including [structure/O95714/pdb_2KEO.pdb], [structure/O95714/pdb_3KCI.pdb], an... |
UBE3A (Q05086), also known as ubiquitin-protein ligase E3A, is a 100 kDa E3 ligase from Homo sapiens, with a length of 875 amino acids. Its structure has been resolved in multiple forms, including [structure/Q05086/pdb_1C4Z.pdb], [structure/Q05086/pdb_1D5F.pdb], [structure/Q05086/pdb_1EQX.pdb], and several AlphaFold mo... |
The interaction network between HERC2 and UBE3A is supported by robust experimental evidence, with a high confidence score of 0.91. This strong association suggests a functional interplay between these two E3 ubiquitin ligases, potentially coordinating the ubiquitination and subsequent proteasomal degradation of shared... |
Nucleophosmin (accession P06748) is a multifunctional protein from Homo sapiens, with a molecular weight of approximately 32.6 kDa. It is involved in a wide array of cellular processes, including ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, and the regulation of key tumor suppress... |
Cellular tumor antigen p53 (accession P04637), also from Homo sapiens, is a pivotal transcription factor with a molecular weight of about 43.7 kDa. It acts as a tumor suppressor, orchestrating cell cycle arrest, DNA repair, and apoptosis in response to cellular stress. The p53 protein is characterized by several distin... |
Within the cellular network, nucleophosmin and p53 are functionally linked, as evidenced by multiple high-confidence INTERACTS_WITH edges. The interaction between P06748 and P04637 is supported by a confidence score of 0.997, with text mining identified as the dominant source of evidence. This strong association is con... |
Heat shock protein HSP 90-alpha (accession P07900) is a highly conserved molecular chaperone from Homo sapiens, with a molecular weight of approximately 84.7 kDa and a length of 732 amino acids. Its overall architecture, as represented by [structure/P07900/alphafold_1.pdb], is characterized by a modular organization th... |
Cellular tumor antigen p53 (accession P04637) is a multifunctional transcription factor from Homo sapiens, with a molecular weight of approximately 43.7 kDa and comprising 393 amino acids. The overall structure, as seen in [structure/P04637/alphafold_1.pdb], is organized into distinct functional domains that enable its... |
The interaction network between HSP90AA1 and p53 is supported by multiple INTERACTS_WITH edges, each with a very high confidence score of 0.999 and a dominant source of text mining, indicating strong literature-based evidence for their association. This interaction is bidirectional and consistently scored across all re... |
Apoptosis regulator Bcl-2 (accession P10415) is a key anti-apoptotic protein in Homo sapiens, with a molecular weight of approximately 26 kDa. Its overall architecture is characterized by a series of Bcl-2 homology (BH) domains, which are critical for its function in suppressing apoptosis and regulating mitochondrial m... |
Cellular tumor antigen p53 (accession P04637) is a multifunctional transcription factor and tumor suppressor with a molecular weight of about 43.6 kDa. The protein is composed of several functional domains, including a transactivation domain at the N-terminus (residues 6 to 30) that is crucial for the recruitment of tr... |
Within the protein interaction network, Bcl-2 and p53 are connected by a highly confident INTERACTS_WITH relationship, supported by multiple edges with a dominant source of text mining and a confidence score of 0.999. This strong association reflects extensive evidence in the literature for their functional interplay: ... |
P14373, also known as Zinc finger protein RFP or TRIM27, is a multifunctional E3 ubiquitin-protein ligase from Homo sapiens, with a molecular weight of approximately 58 kDa and a length of 513 amino acids. Its overall structure is characterized by the tripartite motif (TRIM) architecture, which includes a RING-type zin... |
Q93009, known as Ubiquitin carboxyl-terminal hydrolase 7 (USP7), is a large deubiquitinating enzyme from Homo sapiens, with a molecular weight of about 128 kDa and comprising 1102 amino acids. Its structure includes several well-defined domains, as illustrated in [structure/Q93009/alphafold_1.pdb] and supported by mult... |
The interaction network between P14373 (TRIM27) and Q93009 (USP7) is strongly supported, with multiple INTERACTS_WITH edges exhibiting a high confidence score of 0.97, primarily derived from text mining evidence. This robust association reflects a well-established functional relationship: TRIM27 forms a complex with US... |
Pyruvate kinase PKM (P14618) is a key glycolytic enzyme in Homo sapiens, catalyzing the final, rate-limiting step of glycolysis by transferring a phosphoryl group from phosphoenolpyruvate to ADP, thereby generating ATP. The enzyme’s activity is tightly regulated by its oligomeric state, with the tetrameric form being h... |
Hypoxia-inducible factor 1-alpha (HIF1A, Q16665) is a master transcriptional regulator orchestrating the cellular response to hypoxia. In low-oxygen conditions, HIF1A activates the transcription of a broad array of genes involved in oxygen delivery and metabolic adaptation, including erythropoietin, glucose transporter... |
Within the interaction network, PKM and HIF1A are connected by multiple INTERACTS_WITH edges, each with a high confidence score of 0.996, predominantly supported by text mining evidence. This strong association suggests a functional link between glycolytic regulation and hypoxic transcriptional responses, consistent wi... |
Retinoic acid receptor RXR-alpha (P19793) is a nuclear receptor that functions as a ligand-activated transcription factor, primarily mediating the effects of retinoic acids on gene expression. Structurally, RXR-alpha is characterized by several conserved domains typical of nuclear hormone receptors. The DNA-binding dom... |
CREB-binding protein (Q92793) is a large, multifunctional transcriptional coactivator with intrinsic histone acetyltransferase activity, playing a pivotal role in chromatin remodeling and transcriptional regulation. Its modular structure includes several domains that mediate interactions with transcription factors and ... |
Within the interaction network, RXR-alpha and CREB-binding protein are connected by a high-confidence, experimentally supported interaction, with a confidence score of 0.977. This strong association reflects the established role of CREB-binding protein as a coactivator for nuclear receptors, including RXR-alpha. The in... |
NF-kappa-B inhibitor alpha (accession P25963) is a human protein with a molecular weight of approximately 35.6 kDa, encoded by the NFKBIA gene. Its primary function is to inhibit dimeric NF-kappa-B/REL complexes by sequestering them in the cytoplasm, thereby masking their nuclear localization signals and preventing tra... |
14-3-3 protein sigma (accession P31947), encoded by the SFN gene, is a human adapter protein with a molecular weight of about 27.8 kDa. It is involved in the regulation of a wide array of signaling pathways, often by binding to phosphoserine- or phosphothreonine-containing motifs on partner proteins, thereby modulating... |
The interaction network between NF-kappa-B inhibitor alpha and 14-3-3 protein sigma is supported by experimental evidence, with a high confidence score of 0.918. This strong interaction suggests a biologically relevant association, likely mediated by the ankyrin repeat domains of NF-kappa-B inhibitor alpha and the phos... |
P31749 encodes RAC-alpha serine/threonine-protein kinase, commonly known as AKT1, a central regulator of numerous cellular processes including metabolism, proliferation, survival, growth, and angiogenesis in Homo sapiens. Structurally, AKT1 is characterized by several key domains. Its N-terminal region contains a pleck... |
P31947 encodes the 14-3-3 protein sigma (SFN), an adapter protein that modulates a wide array of signaling pathways by binding to phosphoserine- or phosphothreonine-containing motifs on partner proteins. This binding generally alters the activity, localization, or stability of its targets, thereby influencing processes... |
Within the interaction network, AKT1 (P31749) and 14-3-3 sigma (P31947) are connected by a bidirectional INTERACTS_WITH relationship. The interaction is supported by a high confidence score of 0.827, with text mining identified as the dominant source of evidence. This suggests a well-supported functional association, c... |
The aryl hydrocarbon receptor (AHR, accession P35869) is a ligand-activated transcription factor in Homo sapiens, notable for its ability to sense a diverse array of endogenous and exogenous compounds, including xenobiotics, dietary molecules, and metabolites from the microbiome. Structurally, AHR is characterized by s... |
Heat shock protein HSP 90-alpha (HSP90AA1, accession P07900) is a molecular chaperone essential for the maturation, stability, and regulation of a wide variety of client proteins, particularly those involved in cell cycle control and signal transduction. HSP90AA1 is composed of several conserved domains that facilitate... |
Within the interaction network, AHR and HSP90AA1 are linked by a high-confidence, experimentally supported interaction, with a confidence score of 0.992. This strong association reflects the well-established role of HSP90AA1 as a chaperone for AHR, stabilizing the receptor in its inactive cytoplasmic form and facilitat... |
Stress-70 protein, mitochondrial (HSPA9, accession P38646), is a member of the heat shock protein 70 (Hsp70) family and functions as a mitochondrial chaperone in Homo sapiens. It is essential for mitochondrial protein import, folding, and assembly, and plays a central role in maintaining protein quality control by faci... |
Cellular tumor antigen p53 (TP53, accession P04637) is a multifunctional transcription factor and a critical tumor suppressor in Homo sapiens. It orchestrates cellular responses to stress by inducing cell cycle arrest, DNA repair, or apoptosis, depending on the context. p53 negatively regulates cell division by control... |
The interaction network between HSPA9 and TP53 is supported by multiple INTERACTS_WITH edges, each with a high confidence score of 0.998 and a dominant source of text mining, indicating strong literature-based evidence for their association. The interaction is bidirectional, with both proteins annotated as source and t... |
Signal transducer and activator of transcription 1-alpha/beta (STAT1, accession P42224) is a key transcription factor in Homo sapiens, mediating cellular responses to interferons, cytokines, and various growth factors. Structurally, STAT1 is a multi-domain protein of 750 amino acids and approximately 87 kDa, with its o... |
Histone acetyltransferase p300 (EP300, accession Q09472) is a large, multifunctional nuclear protein of 2414 amino acids and approximately 264 kDa, also from Homo sapiens. p300 functions as a histone acetyltransferase, regulating transcription through chromatin remodeling and acetylation of both histone and non-histone... |
Within the protein interaction network, STAT1 and p300 are strongly connected, with multiple INTERACTS_WITH edges between them, each supported by a high confidence score of 0.998. The dominant source of this interaction evidence is text mining, and the interaction is further characterized by high tscore (0.977), escore... |
The DNA repair protein RAD52 homolog (P43351) from Homo sapiens is a central player in the repair of double-stranded DNA breaks, facilitating genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and stimulating the RAD51 recombinase. Structurally, RAD52 is characterized b... |
Serine/threonine-protein kinase Chk2 (O96017), also from Homo sapiens, is a multifunctional kinase required for checkpoint-mediated cell cycle arrest, activation of DNA repair, and apoptosis in response to DNA double-strand breaks. Chk2 contains a forkhead-associated (FHA) domain between residues 112 and 191 [structure... |
Within the protein interaction network, RAD52 and Chk2 are connected by multiple INTERACTS_WITH edges, each supported by a high confidence score of 0.891. The dominant source for this interaction is text mining, and the interaction is bidirectional, indicating mutual recognition in the literature. While the network dat... |
E3 ubiquitin-protein ligase NEDD4 (P46934) is a large, multidomain protein from Homo sapiens, with a molecular weight of approximately 149 kDa and a length of 1319 amino acids. Its overall architecture, as captured in [structure/P46934/alphafold_1.pdb], is defined by several key domains that confer its function as an E... |
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (P60484) is a 47 kDa tumor suppressor protein, 403 amino acids in length, also from Homo sapiens. Its structure, represented in [structure/P60484/alphafold_1.pdb], is organized into a phosphatase domain and a C2 domain.... |
Within the protein interaction network, NEDD4 and PTEN are connected by robust experimental evidence, with a high confidence score of 0.984. This interaction is supported by multiple independent edges, all dominated by experimental data, and is characterized by strong tscore (0.741) and escore (0.909) values, indicatin... |
Transcriptional coactivator YAP1 (P46937) is a multifunctional protein from Homo sapiens, weighing approximately 54 kDa, that plays a pivotal role in the Hippo signaling pathway, which is essential for organ size control and tumor suppression. YAP1 acts as both a coactivator and corepressor of transcription, modulating... |
14-3-3 protein sigma (P31947), also from Homo sapiens and with a molecular weight of about 28 kDa, serves as an adapter protein involved in a wide array of signaling pathways. It typically binds to phosphorylated serine or threonine motifs on target proteins, thereby modulating their activity, localization, or stabilit... |
Within the interaction network, YAP1 and 14-3-3 sigma are experimentally validated to interact with high confidence (confidence score 0.85). This interaction is central to the regulation of YAP1 activity: phosphorylation of YAP1 by upstream kinases creates binding sites for 14-3-3 proteins, including the sigma isoform,... |
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