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11 values
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stringlengths
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17 values
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stringlengths
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244
10.1002_chem.201805823
CCOC(=O)c1c(-c2ccc([N+](=O)[O-])cc2)c2c(c(C(C)=O)c1)CCCC2
41
41
[0.6484231 0.50078128 0.79644473 0.63828131]
[0.11819637 0.67187507 0.87874031 0.91250001]
13C NMR
176 MHz
CDCl3
202.3, 166.6, 147.8, 147.2, 143.0, 141.6, 139.1, 137.6, 129.5, 127.6, 127.5, 123.6, 61.3, 30.5, 29.4, 28.5, 22.4, 22.2, 13.9
null
[(202.3, None, None), (166.6, None, None), (147.8, None, None), (147.2, None, None), (143.0, None, None), (141.6, None, None), (139.1, None, None), (137.6, None, None), (129.5, None, None), (127.6, None, None), (127.5, None, None), (123.6, None, None), (61.3, None, None), (30.5, None, None), (29.4, None, None), (28.5, ...
21
19
19
10.1002_chem.201805823
c1(-c2c(C(OCC)=O)cc(C(C)=O)c3c2COCC3)ccccc1
43
43
[0.61638856 0.09414063 0.76882876 0.18144532]
[0.11709173 0.21015626 0.87874031 0.56093751]
1H NMR
400 MHz
CDCl3
8.18 (s, 1H), 7.41-7.36 (m, 3H), 7.14-7.09 (m, 2H), 4.40 (q, J = 1.1 Hz, 2H), 3.99 (q, J = 7.1 Hz, 2H), 3.87 (t, J = 5.8 Hz, 2H), 3.24-3.18 (m, 2H), 2.66 (s, 3H), 0.90 (t, J = 7.2 Hz, 3H)
null
[('s', [], '1H', 8.18, 8.18), ('m', [], '3H', 7.41, 7.36), ('m', [], '2H', 7.14, 7.09), ('q', ['1.1Hz'], '2H', 4.4, 4.4), ('q', ['7.1Hz'], '2H', 3.99, 3.99), ('t', ['5.8Hz'], '2H', 3.87, 3.87), ('m', [], '2H', 3.24, 3.18), ('s', [], '3H', 2.66, 2.66), ('t', ['7.2Hz'], '3H', 0.9, 0.9)]
20
10
20
10.1002_chem.201805823
c1(-c2c(C(OCC)=O)cc(C(C)=O)c3c2COCC3)ccccc1
43
43
[0.61638856 0.09414063 0.76882876 0.18144532]
[0.11709173 0.21015626 0.87874031 0.56093751]
13C NMR
126 MHz
CDCl3
200.7, 167.4, 142.8, 138.2, 137.9, 136.1, 135.7, 129.3, 129.2, 128.3, 127.8, 125.4, 67.9, 64.6, 61.1, 29.9, 28.0, 13.7
null
[(200.7, None, None), (167.4, None, None), (142.8, None, None), (138.2, None, None), (137.9, None, None), (136.1, None, None), (135.7, None, None), (129.3, None, None), (129.2, None, None), (128.3, None, None), (127.8, None, None), (125.4, None, None), (67.9, None, None), (64.6, None, None), (61.1, None, None), (29.9, ...
20
18
18
10.1002_anie.201704036
c1ccc(-n2c(C(=C)COC3(C)C=CC(=O)C=C3)cc3ccccc3c2=O)nc1
20
20
[0.15119747 0.64296876 0.35348449 0.72968754]
[0.14691699 0.72031256 0.84781045 0.87656256]
1H NMR
400 MHz
CDCl3
8.54 (dd, J = 4.8, 1.2 Hz, 1H), 8.39 (d, J = 8.0 Hz, 1H), 7.85-7.78 (m, 1H), 7.68 (dd, J = 11.0, 4.1 Hz, 1H), 7.52 (dd, J = 11.9, 7.9 Hz, 2H), 7.38-7.31 (m, 2H), 6.63 (d, J = 10.2 Hz, 2H), 6.51 (s, 1H), 6.22 (d, J = 10.1 Hz, 2H), 5.34 (d, J = 1.3 Hz, 1H), 5.28 (d, J = 1.2 Hz, 1H), 3.61 (s, 2H), 1.38 (s, 3H)
null
[('dd', ['4.8Hz', '1.2Hz'], '1H', 8.54, 8.54), ('d', ['8.0Hz'], '1H', 8.39, 8.39), ('m', [], '1H', 7.85, 7.78), ('dd', ['11.0Hz', '4.1Hz'], '1H', 7.68, 7.68), ('dd', ['11.9Hz', '7.9Hz'], '2H', 7.52, 7.52), ('m', [], '2H', 7.38, 7.31), ('d', ['10.2Hz'], '2H', 6.63, 6.63), ('s', [], '1H', 6.51, 6.51), ('d', ['10.1Hz'], '...
20
14
20
10.1002_anie.201704036
c1ccc(-n2c(C(=C)COC3(C)C=CC(=O)C=C3)cc3ccccc3c2=O)nc1
20
20
[0.15119747 0.64296876 0.35348449 0.72968754]
[0.14691699 0.72031256 0.84781045 0.87656256]
13C NMR
100 MHz
CDCl3
185.0, 163.0, 152.2, 151.3, 149.3, 141.7, 140.9, 137.9, 136.8, 133.1, 130.3, 128.3
null
[(185.0, None, None), (163.0, None, None), (152.2, None, None), (151.3, None, None), (149.3, None, None), (141.7, None, None), (140.9, None, None), (137.9, None, None), (136.8, None, None), (133.1, None, None), (130.3, None, None), (128.3, None, None)]
24
22
12
10.1002_adsc.201300501
CC(C)Nc1nc2ccccc2s1
1
1
[0.11636096 0.15390625 0.28468359 0.21132814]
[0.11401162 0.24140626 0.25124017 0.25468751]
1H NMR
300 MHz
CDCl3
1.32 (d, J = 6.3 Hz, 6 H), 3.85-4.00 (m, 1 H), 5.33 (br. s, 1 H), 7.07 (t, J = 7.2 Hz, 1 H), 7.28 (t, J = 7.2 Hz, 1 H), 7.52 (d, J = 8.1 Hz, 1 H), 7.57 (d, J = 7.8 Hz, 1 H)
null
[('d', ['6.3Hz'], '6H', 1.32, 1.32), ('m', [], '1H', 4.0, 3.85), ('brs', [], '1H', 5.33, 5.33), ('t', ['7.2Hz'], '1H', 7.07, 7.07), ('t', ['7.2Hz'], '1H', 7.28, 7.28), ('d', ['8.1Hz'], '1H', 7.52, 7.52), ('d', ['7.8Hz'], '1H', 7.57, 7.57)]
12
7
12
10.1002_adsc.201300501
CC(C)Nc1nc2ccccc2s1
1
1
[0.11636096 0.15390625 0.28468359 0.21132814]
[0.11401162 0.24140626 0.25124017 0.25468751]
13C NMR
75 MHz
CDCl3
23.05, 47.62, 118.82, 120.73, 121.38, 125.88, 130.44, 152.56, 166.53
null
[(23.05, None, None), (47.62, None, None), (118.82, None, None), (120.73, None, None), (121.38, None, None), (125.88, None, None), (130.44, None, None), (152.56, None, None), (166.53, None, None)]
10
9
9
10.1002_adsc.201300501
CC(C)CNc1nc2ccccc2s1
2
2
[0.11580817 0.06826172 0.30264905 0.12548829]
[0.11442621 0.14414063 0.25704441 0.15742188]
1H NMR
300 MHz
CDCl3
1.01 (d, J = 6.6 Hz, 6 H), 1.91-2.02 (m, 1 H), 3.23 (d, J = 6.9 Hz, 2 H), 5.50 (br. s, 1 H), 7.07 (t, J = 7.8 Hz, 1 H), 7.29 (t, J = 7.5 Hz, 1 H), 7.52 (d, J = 8.1 Hz, 1 H), 7.58 (d, J = 7.2 Hz, 1 H)
null
[('d', ['6.6Hz'], '6H', 1.01, 1.01), ('m', [], '1H', 2.02, 1.91), ('d', ['6.9Hz'], '2H', 3.23, 3.23), ('brs', [], '1H', 5.5, 5.5), ('t', ['7.8Hz'], '1H', 7.07, 7.07), ('t', ['7.5Hz'], '1H', 7.29, 7.29), ('d', ['8.1Hz'], '1H', 7.52, 7.52), ('d', ['7.2Hz'], '1H', 7.58, 7.58)]
14
8
14
10.1002_adsc.201300501
CC(C)CNc1nc2ccccc2s1
2
2
[0.11580817 0.06826172 0.30264905 0.12548829]
[0.11442621 0.14414063 0.25704441 0.15742188]
13C NMR
75 MHz
CDCl3
20.12, 28.61, 53.28, 118.80, 120.75, 121.39, 125.94, 130.39, 152.55, 167.85
null
[(20.12, None, None), (28.61, None, None), (53.28, None, None), (118.8, None, None), (120.75, None, None), (121.39, None, None), (125.94, None, None), (130.39, None, None), (152.55, None, None), (167.85, None, None)]
11
10
10
10.1002_adsc.201300501
CC(C)Nc1nccs1
3
3
[0.11580817 0.31289064 0.23631502 0.37070315]
[0.11276786 0.41640626 0.94415447 0.51562504]
1H NMR
300 MHz
CDCl3
1.28 (d, J = 6.6 Hz, 6 H), 3.66-3.77 (m, 1 H), 5.03 (br. s, 1 H), 6.48 (d, J = 3.6 Hz, 1 H), 7.10 (d, J = 3.6 Hz, 1 H)
null
[('d', ['6.6Hz'], '6H', 1.28, 1.28), ('m', [], '1H', 3.77, 3.66), ('brs', [], '1H', 5.03, 5.03), ('d', ['3.6Hz'], '1H', 6.48, 6.48), ('d', ['3.6Hz'], '1H', 7.1, 7.1)]
10
5
10
10.1002_adsc.201300501
CC(C)Nc1nccs1
3
3
[0.11580817 0.31289064 0.23631502 0.37070315]
[0.11276786 0.41640626 0.94415447 0.51562504]
13C NMR
75 MHz
CDCl3
22.88, 47.90, 106.24, 139.08, 169.42
null
[(22.88, None, None), (47.9, None, None), (106.24, None, None), (139.08, None, None), (169.42, None, None)]
6
5
5
10.1002_adsc.201300501
CNc1nc2ccc(F)cc2s1
4
4
[0.11580817 0.18681642 0.28578914 0.23281251]
[0.11442621 0.25234376 0.25732078 0.26562502]
1H NMR
300 MHz
CDCl3
3.11 (s, 3 H), 5.88 (br. s, 1H), 7.03 (td, J = 9 Hz, J = 2.4 Hz, 1H), 7.31 (dd, J = 8.1 Hz, J = 2.7 Hz, 1H), 7.46 (dd, J = 8.7 Hz, J = 4.8 Hz, 1H)
null
[('s', [], '3H', 3.11, 3.11), ('brs', [], '1H', 5.88, 5.88), ('td', "['9Hz', '2.4Hz']", '1H', 7.03, 7.03), ('dd', "['8.1Hz', '2.7Hz']", '1H', 7.31, 7.31), ('dd', "['8.7Hz', '4.8Hz']", '1H', 7.46, 7.46)]
7
5
7
10.1002_adsc.201300501
CNc1nc2ccc(F)cc2s1
4
4
[0.11580817 0.18681642 0.28578914 0.23281251]
[0.11442621 0.25234376 0.25732078 0.26562502]
19F NMR
376 MHz
CDCl3
-121.56
null
[(-121.56, None, None)]
1
1
1
10.1002_adsc.201300501
c1(CCNc2nc3ccc(F)cc3s2)ccccc1
4
4
[0.11580817 0.68671879 0.34162028 0.73281251]
[0.1147026 0.75234376 0.25732078 0.76562507]
1H NMR
300 MHz
CDCl3
3.02 (t, J = 6.9 Hz, 2H), 3.71 (t, J = 6.9 Hz, 2H), 5.30 (br. s, 1H), 7.03 (td, J = 9.0 Hz, J = 2.7 Hz, 1H), 7.24-7.37 (m, 6H), 7.46 (dd, J = 8.7 Hz, J = 4.8 Hz, 1H)
null
[('t', ['6.9Hz'], '2H', 3.02, 3.02), ('t', ['6.9Hz'], '2H', 3.71, 3.71), ('brs', [], '1H', 5.3, 5.3), ('td', "['9.0Hz', '2.7Hz']", '1H', 7.03, 7.03), ('m', [], '6H', 7.37, 7.24), ('dd', "['8.7Hz', '4.8Hz']", '1H', 7.46, 7.46)]
13
9
13
10.1002_adsc.201300501
c1(CCNc2nc3ccc(F)cc3s2)ccccc1
4
4
[0.11580817 0.68671879 0.34162028 0.73281251]
[0.1147026 0.75234376 0.25732078 0.76562507]
19F NMR
376 MHz
CDCl3
-121.30
null
[(-121.3, None, None)]
1
1
1
10.1002_adsc.201300501
Fc1ccc2nc(-n3cccn3)sc2c1
5
5
[0.11608456 0.41210941 0.31453388 0.45820313]
[0.1147026 0.47734378 0.25732078 0.49062501]
1H NMR
300 MHz
CDCl3
6.55 (m, 1H), 7.22 (td, J = 9 Hz, J = 2.7 Hz, 1H), 7.54 (dd, J = 8.1 Hz, J = 2.7 Hz, 1H), 7.79 (m, 1H), 7.84 (dd, J = 9 Hz, J = 4.8 Hz, 1H), 8.46 (m, 1H)
null
[('m', [], '1H', 6.55, 6.55), ('td', "['9Hz', '2.7Hz']", '1H', 7.22, 7.22), ('dd', "['8.1Hz', '2.7Hz']", '1H', 7.54, 7.54), ('m', [], '1H', 7.79, 7.79), ('dd', "['9Hz', '4.8Hz']", '1H', 7.84, 7.84), ('m', [], '1H', 8.46, 8.46)]
6
6
6
10.1002_adsc.201300501
CCNc1nc(-c2ccc(Cl)cc2)cs1
6
6
[0.11608456 0.11621095 0.3482537 0.19394532]
[0.11414982 0.21210938 0.27805017 0.22851564]
1H NMR
300 MHz
CDCl3
1.28 (t, J = 7.2 Hz, 3H), 3.28-3.37 (m, 2H), 5.54 (br. s, 1H), 6.69 (s, 1H), 7.35 (d, J = 8.7 Hz, 2H), 7.74 (d, J = 8.7 Hz, 2H)
null
[('t', ['7.2Hz'], '3H', 1.28, 1.28), ('m', [], '2H', 3.37, 3.28), ('brs', [], '1H', 5.54, 5.54), ('s', [], '1H', 6.69, 6.69), ('d', ['8.7Hz'], '2H', 7.35, 7.35), ('d', ['8.7Hz'], '2H', 7.74, 7.74)]
11
6
11
10.1002_adsc.201300501
CCNc1nc(-c2ccc(Cl)cc2)cs1
6
6
[0.11608456 0.11621095 0.3482537 0.19394532]
[0.11414982 0.21210938 0.27805017 0.22851564]
13C NMR
75 MHz
CDCl3
14.67, 40.79, 101.01, 127.29 (2C), 128.64 (2C), 133.23, 133.51, 150.41, 169.75
null
[(14.67, None, None), (40.79, None, None), (101.01, None, None), (127.29, None, None), (128.64, None, None), (133.23, None, None), (133.51, None, None), (150.41, None, None), (169.75, None, None)]
11
9
9
10.1002_adsc.201300501
Clc1ccc(-c2csc(-n3cccn3)n2)cc1
6
6
[0.11608456 0.41953127 0.34991204 0.49921879]
[0.11387343 0.51640628 0.25814996 0.53046879]
1H NMR
300 MHz
CDCl3
6.52 (m, 1H), 7.25 (s, 1H), 7.43 (d, J = 8.7 Hz, 2H), 7.76 (d, J = 1.8 Hz, 1H), 7.86 (d, J = 8.7 Hz, 2H), 8.44 (d, J = 2.7 Hz, 1H)
null
[('m', [], '1H', 6.52, 6.52), ('s', [], '1H', 7.25, 7.25), ('d', ['8.7Hz'], '2H', 7.43, 7.43), ('d', ['1.8Hz'], '1H', 7.76, 7.76), ('d', ['8.7Hz'], '2H', 7.86, 7.86), ('d', ['2.7Hz'], '1H', 8.44, 8.44)]
8
6
8
10.1002_adsc.201300501
Clc1ccc(-c2csc(-n3cccn3)n2)cc1
6
6
[0.11608456 0.41953127 0.34991204 0.49921879]
[0.11387343 0.51640628 0.25814996 0.53046879]
13C NMR
75 MHz
CDCl3
108.67, 109.49, 127.38 (2C), 127.47, 128.94 (2C), 132.50, 134.15, 142.79, 151.47, 161.15
null
[(108.67, None, None), (109.49, None, None), (127.38, None, None), (127.47, None, None), (128.94, None, None), (132.5, None, None), (134.15, None, None), (142.79, None, None), (151.47, None, None), (161.15, None, None)]
12
10
10
10.1002_anie.201710866
[Si](C1C=CC=CC=1)(C)(C)/C(=C(/F)\F)/F
4
4
[0.14249844 0.15039063 0.25020073 0.19296875]
[0.14084148 0.20878907 0.8555429 0.24160158]
1H NMR
400 MHz
CDCl3
0.53 (s, 6H), 7.38-7.59 (m, 5H)
null
[('s', [], '6H', 0.53, 0.53), ('m', [], '5H', 7.59, 7.38)]
11
4
11
10.1002_adsc.202200127
Nc1ccccc1-c1cccnc1F
2
2
[0.1208199 0.13671876 0.23128378 0.20195314]
[0.1187487 0.25390627 0.42252443 0.26875001]
1H NMR
600 MHz
CDCl3
8.24 (d, J = 4.7 Hz, 1H), 7.84 (ddd, J = 9.3, 7.6, 1.7 Hz, 1H), 7.29 (ddd, J = 6.9, 5.0, 1.6 Hz, 1H), 7.23 (td, J = 7.8, 1.2 Hz, 1H), 7.11 (d, J = 7.6 Hz, 1H), 6.85 (t, J = 7.4 Hz, 1H), 6.80 (d, J = 8.1 Hz, 1H), 3.66 (br. s, 2H)
null
[('d', ['4.7Hz'], '1H', 8.24, 8.24), ('ddd', ['9.3Hz', '7.6Hz', '1.7Hz'], '1H', 7.84, 7.84), ('ddd', ['6.9Hz', '5.0Hz', '1.6Hz'], '1H', 7.29, 7.29), ('td', ['7.8Hz', '1.2Hz'], '1H', 7.23, 7.23), ('d', ['7.6Hz'], '1H', 7.11, 7.11), ('t', ['7.4Hz'], '1H', 6.85, 6.85), ('d', ['8.1Hz'], '1H', 6.8, 6.8), ('brs', [], '2H', 3...
9
8
9
10.1002_adsc.202200127
Nc1ccccc1-c1cccnc1F
2
2
[0.1208199 0.13671876 0.23128378 0.20195314]
[0.1187487 0.25390627 0.42252443 0.26875001]
13C NMR
151 MHz
CDCl3
160.8 (d, J = 240 Hz), 147.1 (d, J = 14.4 Hz), 144.2, 142.7 (d, J = 4.8 Hz), 131.1, 130.0, 121.9 (d, J = 4.3 Hz), 121.7 (d, J = 31.6 Hz), 119.6 (d, J = 3.8 Hz), 118.9, 116.3
null
[(160.8, 'd', 240.0), (147.1, 'd', 14.4), (144.2, None, None), (142.7, 'd', 4.8), (131.1, None, None), (130.0, None, None), (121.9, 'd', 4.3), (121.7, 'd', 31.6), (119.6, 'd', 3.8), (118.9, None, None), (116.3, None, None)]
11
11
11
10.1002_adsc.202200127
Nc1ccc(Cl)cc1-c1cccnc1F
2
2
[0.12068181 0.80781254 0.23059338 0.89375004]
[0.24522985 0.80625006 0.87929265 0.91250001]
1H NMR
400 MHz
CDCl3
8.26 (d, J = 4.7 Hz, 1H), 7.82 (ddd, J = 9.2, 7.5, 1.5 Hz, 1H), 7.34-7.27 (m, 1H), 7.17 (dd, J = 8.6, 2.3 Hz, 1H), 7.09 (d, J = 2.3 Hz, 1H), 6.73 (d, J = 8.6 Hz, 1H), 3.66 (br. s, 2H)
null
[('d', ['4.7Hz'], '1H', 8.26, 8.26), ('ddd', ['9.2Hz', '7.5Hz', '1.5Hz'], '1H', 7.82, 7.82), ('m', [], '1H', 7.34, 7.27), ('dd', ['8.6Hz', '2.3Hz'], '1H', 7.17, 7.17), ('d', ['2.3Hz'], '1H', 7.09, 7.09), ('d', ['8.6Hz'], '1H', 6.73, 6.73), ('brs', [], '2H', 3.66, 3.66)]
8
7
8
10.1002_adsc.202200127
Nc1ccc(Cl)cc1-c1cccnc1F
2
2
[0.12068181 0.80781254 0.23059338 0.89375004]
[0.24522985 0.80625006 0.87929265 0.91250001]
13C NMR
126 MHz
CDCl3
160.6 (d, J = 240 Hz), 147.6 (d, J = 14.5 Hz), 142.9, 142.6 (d, J = 4.5 Hz), 130.6 (d, J = 0.7 Hz), 129.8, 123.4, 122.1 (d, J = 4.4 Hz), 120.9 (d, J = 4.0 Hz), 120.5 (d, J = 31.6 Hz), 117.4
null
[(160.6, 'd', 240.0), (147.6, 'd', 14.5), (142.9, None, None), (142.6, 'd', 4.5), (130.6, 'd', 0.7), (129.8, None, None), (123.4, None, None), (122.1, 'd', 4.4), (120.9, 'd', 4.0), (120.5, 'd', 31.6), (117.4, None, None)]
11
11
11
10.1002_adsc.202200127
Nc1cccc(F)c1-c1cccnc1F
3
3
[0.12054373 0.37890629 0.23073147 0.44765626]
[0.16569586 0.38046877 0.87929265 0.48515628]
1H NMR
400 MHz
CDCl3
8.28 (d, J = 4.8 Hz, 1H), 7.85 (ddd, J = 9.2, 7.5, 1.8 Hz, 1H), 7.30 (ddd, J = 6.9, 4.9, 1.8 Hz, 1H), 7.18 (td, J = 8.2, 6.5 Hz, 1H), 6.61 (d, J = 8.3 Hz, 1H), 6.60 (t, J = 9.1 Hz, 1H), 3.96 (br. s, 2H)
null
[('d', ['4.8Hz'], '1H', 8.28, 8.28), ('ddd', ['9.2Hz', '7.5Hz', '1.8Hz'], '1H', 7.85, 7.85), ('ddd', ['6.9Hz', '4.9Hz', '1.8Hz'], '1H', 7.3, 7.3), ('td', ['8.2Hz', '6.5Hz'], '1H', 7.18, 7.18), ('d', ['8.3Hz'], '1H', 6.61, 6.61), ('t', ['9.1Hz'], '1H', 6.6, 6.6), ('brs', [], '2H', 3.96, 3.96)]
8
7
8
10.1002_adsc.202200127
Nc1cccc(F)c1-c1cccnc1F
3
3
[0.12054373 0.37890629 0.23073147 0.44765626]
[0.16569586 0.38046877 0.87929265 0.48515628]
13C NMR
126 MHz
CDCl3
161.2 (d, J = 241 Hz), 160.9 (d, J = 245 Hz), 148.0 (d, J = 14.4 Hz), 145.5 (d, J = 5.2 Hz), 143.6 (d, J = 4.3 Hz), 130.7 (d, J = 10.6 Hz), 121.8 (d, J = 4.4 Hz), 114.9 (d, J = 31.1 Hz), 111.7 (d, J = 2.8 Hz), 107.8 (dd, J = 19.6, 3.9 Hz), 105.6 (d, J = 22.5 Hz)
null
[(161.2, 'd', 241.0), (160.9, 'd', 245.0), (148.0, 'd', 14.4), (145.5, 'd', 5.2), (143.6, 'd', 4.3), (130.7, 'd', 10.6), (121.8, 'd', 4.4), (114.9, 'd', 31.1), (111.7, 'd', 2.8), (107.8, 'dd', [19.6, 3.9]), (105.6, 'd', 22.5)]
11
11
11
10.1002_adsc.202200127
Nc1c(F)cc(F)cc1-c1cccnc1F
3
4
[0.12095797 0.80390629 0.25268619 0.88984379]
[0.11819637 0.08808594 0.42252443 0.10234375]
1H NMR
400 MHz
CDCl3
8.29 (d, J = 4.8 Hz, 1H), 7.84 (ddd, J = 9.4, 7.5, 1.8 Hz, 1H), 7.32 (ddd, J = 6.9, 4.9, 1.7 Hz, 1H), 6.88 (ddd, J = 10.9, 8.3, 2.8 Hz, 1H), 6.71 (d, J = 8.7 Hz, 1H), 3.59 (br. s, 2H)
null
[('d', ['4.8Hz'], '1H', 8.29, 8.29), ('ddd', ['9.4Hz', '7.5Hz', '1.8Hz'], '1H', 7.84, 7.84), ('ddd', ['6.9Hz', '4.9Hz', '1.7Hz'], '1H', 7.32, 7.32), ('ddd', ['10.9Hz', '8.3Hz', '2.8Hz'], '1H', 6.88, 6.88), ('d', ['8.7Hz'], '1H', 6.71, 6.71), ('brs', [], '2H', 3.59, 3.59)]
7
6
7
10.1002_adsc.202200127
O(c1ccc(-c2cccnc2F)c(N)c1)C
4
4
[0.12095797 0.41953127 0.27671208 0.48984377]
[0.29576709 0.41796879 0.87929265 0.50859378]
1H NMR
400 MHz
CDCl3
8.21 (d, J = 4.8 Hz, 1H), 7.82 (ddd, J = 9.3, 7.5, 1.7 Hz, 1H), 7.28-7.24 (m, 1H), 7.05 (d, J = 8.4 Hz, 1H), 6.48 (dd, J = 8.4, 2.3 Hz, 1H), 6.41 (d, J = 2.3 Hz, 1H), 4.16 (br. s, 2H), 3.82 (s, 3H)
null
[('d', ['4.8Hz'], '1H', 8.21, 8.21), ('ddd', ['9.3Hz', '7.5Hz', '1.7Hz'], '1H', 7.82, 7.82), ('m', [], '1H', 7.28, 7.24), ('d', ['8.4Hz'], '1H', 7.05, 7.05), ('dd', ['8.4Hz', '2.3Hz'], '1H', 6.48, 6.48), ('d', ['2.3Hz'], '1H', 6.41, 6.41), ('brs', [], '2H', 4.16, 4.16), ('s', [], '3H', 3.82, 3.82)]
11
8
11
10.1002_adsc.202200127
O(c1ccc(-c2cccnc2F)c(N)c1)C
4
4
[0.12095797 0.41953127 0.27671208 0.48984377]
[0.29576709 0.41796879 0.87929265 0.50859378]
13C NMR
126 MHz
CDCl3
161.2, 161.0 (d, J = 239 Hz), 146.8 (d, J = 14.4 Hz), 144.4, 142.8 (d, J = 4.8 Hz), 132.2, 121.9 (d, J = 4.3 Hz), 121.3 (d, J = 31.4 Hz), 113.1 (d, J = 3.9 Hz), 105.6, 102.1, 55.4
null
[(161.2, None, None), (161.0, 'd', 239.0), (146.8, 'd', 14.4), (144.4, None, None), (142.8, 'd', 4.8), (132.2, None, None), (121.9, 'd', 4.3), (121.3, 'd', 31.4), (113.1, 'd', 3.9), (105.6, None, None), (102.1, None, None), (55.4, None, None)]
12
12
12
10.1002_adsc.202200127
O(c1ccc(N)c(-c2cccnc2F)c1)C(F)(F)F
5
5
[0.12068181 0.11484375 0.2416398 0.20058595]
[0.25793321 0.11425782 0.87763573 0.20351564]
1H NMR
400 MHz
CDCl3
8.27 (d, J = 4.7 Hz, 1H), 7.84 (ddd, J = 9.4, 7.4, 1.9 Hz, 1H), 7.32 (ddd, J = 6.9, 4.9, 1.7 Hz, 1H), 7.11 (dd, J = 8.8, 1.9 Hz, 1H), 7.01 (d, J = 2.1 Hz, 1H), 6.81 (d, J = 8.8 Hz, 1H), 3.92 (br. s, 2H)
null
[('d', ['4.7Hz'], '1H', 8.27, 8.27), ('ddd', ['9.4Hz', '7.4Hz', '1.9Hz'], '1H', 7.84, 7.84), ('ddd', ['6.9Hz', '4.9Hz', '1.7Hz'], '1H', 7.32, 7.32), ('dd', ['8.8Hz', '1.9Hz'], '1H', 7.11, 7.11), ('d', ['2.1Hz'], '1H', 7.01, 7.01), ('d', ['8.8Hz'], '1H', 6.81, 6.81), ('brs', [], '2H', 3.92, 3.92)]
8
7
8
10.1002_adsc.202200127
O(c1ccc(N)c(-c2cccnc2F)c1)C(F)(F)F
5
5
[0.12068181 0.11484375 0.2416398 0.20058595]
[0.25793321 0.11425782 0.87763573 0.20351564]
13C NMR
126 MHz
CDCl3
160.6 (d, J = 240 Hz), 147.8 (d, J = 14.5 Hz), 142.6 (d, J = 4.4 Hz), 142.5, 141.6 (q, J = 1.9 Hz), 124.0, 123.1, 122.1 (d, J = 4.5 Hz), 120.8 (q, J = 256 Hz), 120.6 (d, J = 3.9 Hz), 120.2 (d, J = 31.5 Hz), 117.2
null
[(160.6, 'd', 240.0), (147.8, 'd', 14.5), (142.6, 'd', 4.4), (142.5, None, None), (141.6, 'q', 1.9), (124.0, None, None), (123.1, None, None), (122.1, 'd', 4.5), (120.8, 'q', 256.0), (120.6, 'd', 3.9), (120.2, 'd', 31.5), (117.2, None, None)]
12
12
12
10.1002_adsc.202200127
Nc1ccccc1-c1ccc(Cl)nc1F
5
5
[0.12206261 0.56171879 0.266218 0.62734376]
[0.28057831 0.56250004 0.87818797 0.6328125 ]
1H NMR
400 MHz
CDCl3
7.82 (t, J = 8.5 Hz, 1H), 7.33 (d, J = 7.8 Hz, 1H), 7.23 (t, J = 7.7 Hz, 1H), 7.08 (d, J = 7.6 Hz, 1H), 6.85 (t, J = 7.6 Hz, 1H), 6.81 (d, J = 8.1 Hz, 1H), 3.64 (br. s, 2H)
null
[('t', ['8.5Hz'], '1H', 7.82, 7.82), ('d', ['7.8Hz'], '1H', 7.33, 7.33), ('t', ['7.7Hz'], '1H', 7.23, 7.23), ('d', ['7.6Hz'], '1H', 7.08, 7.08), ('t', ['7.6Hz'], '1H', 6.85, 6.85), ('d', ['8.1Hz'], '1H', 6.81, 6.81), ('brs', [], '2H', 3.64, 3.64)]
8
7
8
10.1002_adsc.202200127
Nc1ccccc1-c1ccc(Cl)nc1F
5
5
[0.12206261 0.56171879 0.266218 0.62734376]
[0.28057831 0.56250004 0.87818797 0.6328125 ]
13C NMR
126 MHz
CDCl3
159.4 (d, J = 247 Hz), 147.9 (d, J = 13.6 Hz), 144.7 (d, J = 4.8 Hz), 144.2, 131.0 (d, J = 0.8 Hz), 130.3, 122.3 (d, J = 5.1 Hz), 120.1 (d, J = 29.8 Hz), 119.1, 118.3 (d, J = 3.9 Hz), 116.4
null
[(159.4, 'd', 247.0), (147.9, 'd', 13.6), (144.7, 'd', 4.8), (144.2, None, None), (131.0, 'd', 0.8), (130.3, None, None), (122.3, 'd', 5.1), (120.1, 'd', 29.8), (119.1, None, None), (118.3, 'd', 3.9), (116.4, None, None)]
11
11
11
10.1002_adsc.202200127
Nc1ccccc1-c1ccc(F)nc1F
6
6
[0.12178646 0.21015626 0.25765704 0.27578126]
[0.273122 0.21093752 0.87818797 0.28164064]
1H NMR
400 MHz
CDCl3
7.94 (app q, J = 7.9 Hz, 1H), 7.25 (td, J = 7.7, 1.2 Hz, 1H), 7.10 (d, J = 7.5 Hz, 1H), 6.93 (dd, J = 8.0, 2.8 Hz, 1H), 6.89 (td, J = 7.6, 0.8 Hz, 1H), 6.85 (d, J = 8.1 Hz, 1H), 4.03 (br. s, 2H)
null
[('app q', ['7.9Hz'], '1H', 7.94, 7.94), ('td', ['7.7Hz', '1.2Hz'], '1H', 7.25, 7.25), ('d', ['7.5Hz'], '1H', 7.1, 7.1), ('dd', ['8.0Hz', '2.8Hz'], '1H', 6.93, 6.93), ('td', ['7.6Hz', '0.8Hz'], '1H', 6.89, 6.89), ('d', ['8.1Hz'], '1H', 6.85, 6.85), ('brs', [], '2H', 4.03, 4.03)]
8
7
8
10.1002_adsc.202200127
Cc1ccc(-c2ccc(F)nc2F)c(N)c1
6
6
[0.12123413 0.68515631 0.2902439 0.75390632]
[0.1180583 0.82343754 0.42197211 0.83906254]
1H NMR
400 MHz
CDCl3
7.92 (app q, J = 8.0 Hz, 1H), 6.99 (d, J = 7.7 Hz, 1H), 6.91 (dd, J = 8.0, 2.8 Hz, 1H), 6.71 (d, J = 7.8 Hz, 1H), 6.67 (s, 1H), 3.96 (br. s, 2H), 2.33 (s, 3H)
null
[('app q', ['8.0Hz'], '1H', 7.92, 7.92), ('d', ['7.7Hz'], '1H', 6.99, 6.99), ('dd', ['8.0Hz', '2.8Hz'], '1H', 6.91, 6.91), ('d', ['7.8Hz'], '1H', 6.71, 6.71), ('s', [], '1H', 6.67, 6.67), ('brs', [], '2H', 3.96, 3.96), ('s', [], '3H', 2.33, 2.33)]
10
7
10
10.1002_adsc.202200127
Nc1cc(Cl)ccc1-c1ccc(F)nc1F
7
7
[0.12123413 0.28242188 0.28306376 0.35195314]
[0.11861062 0.42109376 0.42252443 0.43515627]
1H NMR
400 MHz
CDCl3
7.91 (dt, J = 9.1, 7.9 Hz, 1H), 7.00 (d, J = 8.3 Hz, 1H), 6.94 (dd, J = 8.0, 2.9 Hz, 1H), 6.91-6.74 (m, 2H), 3.93 (br. s, 2H)
null
[('dt', ['9.1Hz', '7.9Hz'], '1H', 7.91, 7.91), ('d', ['8.3Hz'], '1H', 7.0, 7.0), ('dd', ['8.0Hz', '2.9Hz'], '1H', 6.94, 6.94), ('m', [], '2H', 6.91, 6.74), ('brs', [], '2H', 3.93, 3.93)]
7
6
7
10.1002_adsc.202200127
Nc1ccc(F)cc1-c1ccc(F)nc1F
7
7
[0.1215103 0.71132814 0.2573809 0.79804692]
[0.11736789 0.85000001 0.42307674 0.89062507]
1H NMR
400 MHz
CDCl3
7.94 (app q, J = 8.3 Hz, 1H), 7.00 (td, J = 8.4, 2.9 Hz, 1H), 6.94 (dd, J = 8.1, 1.5 Hz, 1H), 6.90-6.82 (m, 2H), 4.41 (br. s, 2H)
null
[('app q', ['8.3Hz'], '1H', 7.94, 7.94), ('td', ['8.4Hz', '2.9Hz'], '1H', 7.0, 7.0), ('dd', ['8.1Hz', '1.5Hz'], '1H', 6.94, 6.94), ('m', [], '2H', 6.9, 6.82), ('brs', [], '2H', 4.41, 4.41)]
7
6
7
10.1002_adsc.202200127
O(c1ccc(N)c(-c2ccc(F)nc2F)c1)C
8
8
[0.1215103 0.34609376 0.26097098 0.43203126]
[0.11861062 0.48476564 0.42362906 0.49882815]
1H NMR
400 MHz
CDCl3
7.95 (dt, J = 9.2, 8.0 Hz, 1H), 6.92 (dd, J = 8.0, 2.8 Hz, 1H), 6.86 (dd, J = 8.7, 2.7 Hz, 1H), 6.80 (d, J = 8.7 Hz, 1H), 6.68 (d, J = 2.7 Hz, 1H), 3.80 (br. s, 2H), 3.77 (s, 3H)
null
[('dt', ['9.2Hz', '8.0Hz'], '1H', 7.95, 7.95), ('dd', ['8.0Hz', '2.8Hz'], '1H', 6.92, 6.92), ('dd', ['8.7Hz', '2.7Hz'], '1H', 6.86, 6.86), ('d', ['8.7Hz'], '1H', 6.8, 6.8), ('d', ['2.7Hz'], '1H', 6.68, 6.68), ('brs', [], '2H', 3.8, 3.8), ('s', [], '3H', 3.77, 3.77)]
10
7
10
10.1002_adsc.202200127
Nc1ccccc1-c1c(F)ccnc1F
8
8
[0.11888677 0.79492195 0.22879835 0.86093756]
[0.17011441 0.79296882 0.87818797 0.88671882]
1H NMR
600 MHz
CDCl3
8.23 (dd, J = 7.9, 5.8 Hz, 1H), 7.26 (td, J = 7.4 , 1.2 Hz, 1H), 7.12-7.08 (m, 2H), 6.86 (t, J = 7.5 Hz, 1H), 6.83 (d, J = 8.1 Hz, 1H), 3.61 (br. s, 2H)
null
[('dd', ['7.9Hz', '5.8Hz'], '1H', 8.23, 8.23), ('td', ['7.4Hz', '1.2Hz'], '1H', 7.26, 7.26), ('m', [], '2H', 7.12, 7.08), ('t', ['7.5Hz'], '1H', 6.86, 6.86), ('d', ['8.1Hz'], '1H', 6.83, 6.83), ('brs', [], '2H', 3.61, 3.61)]
8
7
8
10.1002_adsc.202200127
Cc1cnc(F)c(-c2ccc(Cl)cc2N)c1
9
9
[0.12233877 0.37929689 0.28969158 0.44882815]
[0.11847253 0.51796876 0.42224826 0.53203128]
1H NMR
400 MHz
CDCl3
8.03 (s, 1H), 7.60 (dd, J = 9.1, 2.1 Hz, 1H), 7.02 (d, J = 7.9 Hz, 1H), 6.86-6.79 (m, 2H), 3.91 (br. s, 2H), 2.36 (s, 3H)
null
[('s', [], '1H', 8.03, 8.03), ('dd', ['9.1Hz', '2.1Hz'], '1H', 7.6, 7.6), ('d', ['7.9Hz'], '1H', 7.02, 7.02), ('m', [], '2H', 6.86, 6.79), ('brs', [], '2H', 3.91, 3.91), ('s', [], '3H', 2.36, 2.36)]
10
7
10
10.1002_adsc.202200127
Cc1cnc(F)c(-c2ccc(Cl)cc2N)c1
9
9
[0.12233877 0.37929689 0.28969158 0.44882815]
[0.11847253 0.51796876 0.42224826 0.53203128]
13C NMR
126 MHz
CDCl3
159.1 (d, J = 237 Hz), 147.1 (d, J = 14.1 Hz), 144.8, 143.2 (d, J = 4.3 Hz), 135.5, 132.2, 131.7 (d, J = 4.8 Hz), 119.6 (d, J = 32.1 Hz), 119.3, 118.5 (d, J = 4.0 Hz), 116.1, 17.5
null
[(159.1, 'd', 237.0), (147.1, 'd', 14.1), (144.8, None, None), (143.2, 'd', 4.3), (135.5, None, None), (132.2, None, None), (131.7, 'd', 4.8), (119.6, 'd', 32.1), (119.3, None, None), (118.5, 'd', 4.0), (116.1, None, None), (17.5, None, None)]
12
12
12
10.1002_adsc.202200127
Nc1ccccc1-c1ccncc1F
9
9
[0.12261493 0.82578131 0.2374974 0.89296876]
[0.25379082 0.82656251 0.87929265 0.89843757]
1H NMR
400 MHz
CDCl3
8.56 (s, 1H), 8.48 (d, J = 4.8 Hz, 1H), 7.39 (dd, J = 5.8, 5.4 Hz, 1H), 7.28-7.23 (m, 1H), 7.13 (d, J = 7.6 Hz, 1H), 6.86 (t, J = 7.5 Hz, 1H), 6.82 (d, J = 8.1 Hz, 1H), 3.70 (br. s, 2H)
null
[('s', [], '1H', 8.56, 8.56), ('d', ['4.8Hz'], '1H', 8.48, 8.48), ('dd', ['5.8Hz', '5.4Hz'], '1H', 7.39, 7.39), ('m', [], '1H', 7.28, 7.23), ('d', ['7.6Hz'], '1H', 7.13, 7.13), ('t', ['7.5Hz'], '1H', 6.86, 6.86), ('d', ['8.1Hz'], '1H', 6.82, 6.82), ('brs', [], '2H', 3.7, 3.7)]
9
8
9
10.1002_adsc.202200127
Nc1ccccc1-c1ccncc1F
9
9
[0.12261493 0.82578131 0.2374974 0.89296876]
[0.25379082 0.82656251 0.87929265 0.89843757]
13C NMR
126 MHz
CDCl3
156.9 (d, J = 257 Hz), 146.0 (d, J = 5.1 Hz), 143.9, 138.9 (d, J = 25.4 Hz), 135.0 (d, J = 13.6 Hz), 130.7 (d, J = 0.9 Hz), 130.5, 126.1, 118.9, 118.5, 116.4
null
[(156.9, 'd', 257.0), (146.0, 'd', 5.1), (143.9, None, None), (138.9, 'd', 25.4), (135.0, 'd', 13.6), (130.7, 'd', 0.9), (130.5, None, None), (126.1, None, None), (118.9, None, None), (118.5, None, None), (116.4, None, None)]
11
11
11
10.1002_adsc.202200127
O(c1ccc(-c2ccnc(C)c2F)c(N)c1)C
10
10
[0.12233877 0.42421876 0.2833399 0.51015626]
[0.29990949 0.42343752 0.87874031 0.51250003]
1H NMR
400 MHz
CDCl3
8.32 (d, J = 5.0 Hz, 1H), 7.26-7.23 (m, 1H), 7.06 (d, J = 8.5 Hz, 1H), 6.44 (dd, J = 8.5, 2.3 Hz, 1H), 6.34 (d, J = 2.3 Hz, 1H), 4.10-3.58 (br. s, 2H), 3.81 (s, 3H), 2.63 (s, 3H)
null
[('d', ['5.0Hz'], '1H', 8.32, 8.32), ('m', [], '1H', 7.26, 7.23), ('d', ['8.5Hz'], '1H', 7.06, 7.06), ('dd', ['8.5Hz', '2.3Hz'], '1H', 6.44, 6.44), ('d', ['2.3Hz'], '1H', 6.34, 6.34), ('brs', [], '2H', 4.1, 3.58), ('s', [], '3H', 3.81, 3.81), ('s', [], '3H', 2.63, 2.63)]
13
8
13
10.1002_adsc.202200127
O(c1ccc(-c2ccnc(C)c2F)c(N)c1)C
10
10
[0.12233877 0.42421876 0.2833399 0.51015626]
[0.29990949 0.42343752 0.87874031 0.51250003]
13C NMR
126 MHz
CDCl3
161.6, 155.4 (d, J = 255 Hz), 147.4 (d, J = 19.1 Hz), 145.4, 144.1, 131.9 (d, J = 1.4 Hz), 124.5, 111.7, 105.1, 101.5, 55.4, 18.0
null
[(161.6, None, None), (155.4, 'd', 255.0), (147.4, 'd', 19.1), (145.4, None, None), (144.1, None, None), (131.9, 'd', 1.4), (124.5, None, None), (111.7, None, None), (105.1, None, None), (101.5, None, None), (55.4, None, None), (18.0, None, None)]
13
13
12
10.1002_adsc.202200127
Nc1ccccc1-c1c(F)cncc1F
11
11
[0.12206261 0.11328126 0.23694506 0.17929688]
[0.25379082 0.1140625 0.87929265 0.18515625]
1H NMR
400 MHz
CDCl3
8.46 (s, 2H), 7.28 (t, J = 7.9 Hz, 1H), 7.12 (d, J = 7.6 Hz, 1H), 6.88 (t, J = 7.5 Hz, 1H), 6.85 (d, J = 8.5 Hz, 1H), 3.64 (br. s, 2H)
null
[('s', [], '2H', 8.46, 8.46), ('t', ['7.9Hz'], '1H', 7.28, 7.28), ('d', ['7.6Hz'], '1H', 7.12, 7.12), ('t', ['7.5Hz'], '1H', 6.88, 6.88), ('d', ['8.5Hz'], '1H', 6.85, 6.85), ('brs', [], '2H', 3.64, 3.64)]
8
6
8
10.1002_adsc.202200127
Nc1ccc(Cl)cc1-c1c(F)cncc1F
11
11
[0.12261493 0.52578126 0.23694506 0.61171876]
[0.11764406 0.66367193 0.42252443 0.67851565]
1H NMR
500 MHz
CDCl3
8.47 (s, 2H), 7.24 (dd, J = 8.7, 2.4 Hz, 1H), 7.11 (d, J = 2.3 Hz, 1H), 6.79 (d, J = 8.7 Hz, 1H), 3.61 (br. s, 2H)
null
[('s', [], '2H', 8.47, 8.47), ('dd', ['8.7Hz', '2.4Hz'], '1H', 7.24, 7.24), ('d', ['2.3Hz'], '1H', 7.11, 7.11), ('d', ['8.7Hz'], '1H', 6.79, 6.79), ('brs', [], '2H', 3.61, 3.61)]
7
5
7
10.1002_adsc.202200127
Nc1ccc(Cl)cc1-c1c(F)cncc1F
11
11
[0.12261493 0.52578126 0.23694506 0.61171876]
[0.11764406 0.66367193 0.42252443 0.67851565]
13C NMR
126 MHz
CDCl3
156.6 (d, J = 262 Hz), 143,0, 135.0 (dd, J = 23.8, 4.8 Hz), 130.9, 130.6, 123.5, 122.3 (t, J = 17.5 Hz), 117.8, 113.2
null
[(156.6, 'd', 262.0), (143.0, None, None), (0.0, None, None), (135.0, 'dd', [23.8, 4.8]), (130.9, None, None), (130.6, None, None), (123.5, None, None), (122.3, 't', 17.5), (117.8, None, None), (113.2, None, None)]
11
9
10
10.1002_adsc.202200127
Nc1ccccc1-c1ccnc(F)c1F
12
12
[0.12233877 0.11328126 0.23694506 0.19570314]
[0.25379082 0.1140625 0.87929265 0.20312502]
1H NMR
600 MHz
CDCl3
8.01 (d, J = 5.0 Hz, 1H), 7.30-7.23 (m, 2H), 7.13 (d, J = 7.6 Hz, 1H), 6.87 (t, J = 7.5 Hz, 1H), 6.82 (d, J = 8.1 Hz, 1H), 3.73 (br. s, 2H)
null
[('d', ['5.0Hz'], '1H', 8.01, 8.01), ('m', [], '2H', 7.3, 7.23), ('d', ['7.6Hz'], '1H', 7.13, 7.13), ('t', ['7.5Hz'], '1H', 6.87, 6.87), ('d', ['8.1Hz'], '1H', 6.82, 6.82), ('brs', [], '2H', 3.73, 3.73)]
8
7
8
10.1002_adsc.202200127
Nc1cc(Cl)ccc1-c1ccnc(F)c1F
12
12
[0.12233877 0.54453127 0.26345641 0.63046881]
[0.28085448 0.54296879 0.87929265 0.63359378]
1H NMR
400 MHz
CDCl3
8.02 (d, J = 5.0 Hz, 1H), 7.23 (t, J = 4.7 Hz, 1H), 7.05 (d, J = 8.0 Hz, 1H), 6.86-6.80 (m, 2H), 3.80 (br. s, 2H)
null
[('d', ['5.0Hz'], '1H', 8.02, 8.02), ('t', ['4.7Hz'], '1H', 7.23, 7.23), ('d', ['8.0Hz'], '1H', 7.05, 7.05), ('m', [], '2H', 6.86, 6.8), ('brs', [], '2H', 3.8, 3.8)]
7
6
7
10.1002_adsc.202200127
O(c1ccc(-c2ccnc(F)c2F)c(N)c1)C
13
13
[0.12261493 0.11337891 0.2833399 0.19873049]
[0.3004618 0.11289063 0.87818797 0.20117189]
1H NMR
400 MHz
CDCl3
8.00 (d, J = 5.0 Hz, 1H), 7.26 (dd, J = 8.5, 3.6 Hz, 1H), 7.09 (d, J = 8.5 Hz, 1H), 6.47 (dd, J = 8.5, 2.3 Hz, 1H), 6.36 (d, J = 2.3 Hz, 1H), 3.83 (s, 3H), 3.78 (br. s, 2H)
null
[('d', ['5.0Hz'], '1H', 8.0, 8.0), ('dd', ['8.5Hz', '3.6Hz'], '1H', 7.26, 7.26), ('d', ['8.5Hz'], '1H', 7.09, 7.09), ('dd', ['8.5Hz', '2.3Hz'], '1H', 6.47, 6.47), ('d', ['2.3Hz'], '1H', 6.36, 6.36), ('s', [], '3H', 3.83, 3.83), ('brs', [], '2H', 3.78, 3.78)]
10
7
10
10.1002_adsc.202200127
Nc1ccccc1-c1cc(F)ncc1F
13
13
[0.12178646 0.54218754 0.2573809 0.60703127]
[0.26179944 0.54218754 0.87818797 0.61171876]
1H NMR
500 MHz
CDCl3
8.14 (s, 1H), 7.26 (td, J = 7.1, 1.5 Hz, 1H), 7.12 (d, J = 7.6 Hz, 1H), 7.02 (dd, J = 4.6, 2.9 Hz, 1H), 6.86 (td, J = 7.6, 0.9 Hz, 1H), 6.81 (d, J = 8.1 Hz, 1H), 3.73 (br. s, 2H)
null
[('s', [], '1H', 8.14, 8.14), ('td', ['7.1Hz', '1.5Hz'], '1H', 7.26, 7.26), ('d', ['7.6Hz'], '1H', 7.12, 7.12), ('dd', ['4.6Hz', '2.9Hz'], '1H', 7.02, 7.02), ('td', ['7.6Hz', '0.9Hz'], '1H', 6.86, 6.86), ('d', ['8.1Hz'], '1H', 6.81, 6.81), ('brs', [], '2H', 3.73, 3.73)]
8
7
8
10.1002_adsc.202200127
COc1ccc(-c2cc(F)ncc2F)c(N)c1
14
14
[0.12178646 0.11601563 0.30294725 0.18515625]
[0.32089764 0.11523438 0.87874031 0.20390626]
1H NMR
500 MHz
CDCl3
8.10 (s, 1H), 7.06 (d, J = 8.5 Hz, 1H), 7.00 (dd, J = 4.7, 2.7 Hz, 1H), 6.46 (dd, J = 8.5, 2.4 Hz, 1H), 6.36 (d, J = 2.4 Hz, 1H), 4.06 (br. s, 2H), 3.81 (s, 3H)
null
[('s', [], '1H', 8.1, 8.1), ('d', ['8.5Hz'], '1H', 7.06, 7.06), ('dd', ['4.7Hz', '2.7Hz'], '1H', 7.0, 7.0), ('dd', ['8.5Hz', '2.4Hz'], '1H', 6.46, 6.46), ('d', ['2.4Hz'], '1H', 6.36, 6.36), ('brs', [], '2H', 4.06, 4.06), ('s', [], '3H', 3.81, 3.81)]
10
7
10
10.1002_adsc.202200127
Clc1ccc2[nH]c3ncccc3c2c1
15
15
[0.12040566 0.28203126 0.2587617 0.34921877]
[0.11902486 0.39785158 0.41009724 0.41328126]
1H NMR
400 MHz
DMSO-d6
11.95 (s, 1 H), 8.56 (dd, J = 7.8, 1.7 Hz, 1 H), 8.45 (dd, J = 4.8, 1.7 Hz, 1 H), 8.29 (d, J = 2.0 Hz, 1 H), 7.51 (d, J = 8.6 Hz, 1 H), 7.46 (dd, J = 8.6, 2.1 Hz, 1 H), 7.23 (dd, J = 7.7, 4.8 Hz, 1 H)
null
[('s', [], '1H', 11.95, 11.95), ('dd', ['7.8Hz', '1.7Hz'], '1H', 8.56, 8.56), ('dd', ['4.8Hz', '1.7Hz'], '1H', 8.45, 8.45), ('d', ['2.0Hz'], '1H', 8.29, 8.29), ('d', ['8.6Hz'], '1H', 7.51, 7.51), ('dd', ['8.6Hz', '2.1Hz'], '1H', 7.46, 7.46), ('dd', ['7.7Hz', '4.8Hz'], '1H', 7.23, 7.23)]
7
7
7
10.1002_adsc.202200127
Clc1ccc2[nH]c3ncccc3c2c1
15
15
[0.12040566 0.28203126 0.2587617 0.34921877]
[0.11902486 0.39785158 0.41009724 0.41328126]
13C NMR
126 MHz
DMSO-d6
152.2, 147.0, 137.2, 129.2, 126.4, 123.7, 121.7, 120.8, 115.3, 114.4, 112.8
null
[(152.2, None, None), (147.0, None, None), (137.2, None, None), (129.2, None, None), (126.4, None, None), (123.7, None, None), (121.7, None, None), (120.8, None, None), (115.3, None, None), (114.4, None, None), (112.8, None, None)]
11
11
11
10.1002_adsc.202200127
Fc1cccc2[nH]c3ncccc3c12
15
15
[0.12095797 0.60546879 0.24191594 0.68046878]
[0.24081131 0.60546879 0.87818797 0.71484382]
1H NMR
400 MHz
DMSO-d6
12.12 (s, 1 H), 8.47 (dd, J = 4.8, 1.6 Hz, 1 H), 8.38 (dd, J = 7.7, 1.6 Hz, 1 H), 7.46 (td, J = 8.0, 5.5 Hz, 1 H), 7.35 (d, J = 8.0 Hz, 1 H), 7.26 (dd, J = 7.7, 4.8 Hz, 1 H), 7.02 (dd, J = 10.4, 8.0 Hz, 1H)
null
[('s', [], '1H', 12.12, 12.12), ('dd', ['4.8Hz', '1.6Hz'], '1H', 8.47, 8.47), ('dd', ['7.7Hz', '1.6Hz'], '1H', 8.38, 8.38), ('td', ['8.0Hz', '5.5Hz'], '1H', 7.46, 7.46), ('d', ['8.0Hz'], '1H', 7.35, 7.35), ('dd', ['7.7Hz', '4.8Hz'], '1H', 7.26, 7.26), ('dd', ['10.4Hz', '8.0Hz'], '1H', 7.02, 7.02)]
7
7
7
10.1002_adsc.202200127
Fc1cccc2[nH]c3ncccc3c12
15
15
[0.12095797 0.60546879 0.24191594 0.68046878]
[0.24081131 0.60546879 0.87818797 0.71484382]
13C NMR
126 MHz
DMSO-d6
157.9 (d, J = 247 Hz), 151.4, 146.5, 140.9 (d, J = 9.9 Hz), 129.9 (d, J = 2.8 Hz), 127.6 (d, J = 8.3 Hz), 115.7, 112.3 (d, J = 1.7 Hz), 108.5 (d, J = 20.5 Hz), 107.7 (d, J = 3.4 Hz), 105.0 (d, J = 18.4 Hz)
null
[(157.9, 'd', 247.0), (151.4, None, None), (146.5, None, None), (140.9, 'd', 9.9), (129.9, 'd', 2.8), (127.6, 'd', 8.3), (115.7, None, None), (112.3, 'd', 1.7), (108.5, 'd', 20.5), (107.7, 'd', 3.4), (105.0, 'd', 18.4)]
11
11
11
10.1002_adsc.202200127
Fc1cc(F)c2[nH]c3ncccc3c2c1
16
16
[0.12068181 0.11328126 0.25489544 0.18066408]
[0.11847253 0.23007813 0.2703604 0.24414064]
1H NMR
400 MHz
DMSO-d6
12.33 (br. s, 1H), 8.57 (d, J = 7.8 Hz, 1H), 8.51 (d, J = 4.7 Hz, 1H), 7.93 (dd, J = 8.7, 1.8 Hz, 1H), 7.39 (ddd, J = 11.3, 9.7, 1.8 Hz, 1H), 7.26 (dd, J = 7.7, 4.8 Hz, 1H)
null
[('brs', [], '1H', 12.33, 12.33), ('d', ['7.8Hz'], '1H', 8.57, 8.57), ('d', ['4.7Hz'], '1H', 8.51, 8.51), ('dd', ['8.7Hz', '1.8Hz'], '1H', 7.93, 7.93), ('ddd', ['11.3Hz', '9.7Hz', '1.8Hz'], '1H', 7.39, 7.39), ('dd', ['7.7Hz', '4.8Hz'], '1H', 7.26, 7.26)]
6
6
6
10.1002_adsc.202200127
COc1ccc2c(c1)[nH]c1ncccc12
16
16
[0.12040566 0.50703129 0.29355781 0.56171879]
[0.31095588 0.50781254 0.87874031 0.57734379]
1H NMR
400 MHz
DMSO-d6
11.66 (s, 1 H), 8.35 (dd, J = 7.6, 1.6 Hz, 1 H), 8.30 (dd, J = 4.9, 1.6 Hz, 1 H), 8.01 (d, J = 8.6 Hz, 1 H), 7.14 (dd, J = 7.6, 4.9 Hz, 1 H), 6.97 (d, J = 2.2 Hz, 1 H), 6.83 (dd, J = 8.6, 2.2 Hz, 1 H), 3.85 (s, 3 H)
null
[('s', [], '1H', 11.66, 11.66), ('dd', ['7.6Hz', '1.6Hz'], '1H', 8.35, 8.35), ('dd', ['4.9Hz', '1.6Hz'], '1H', 8.3, 8.3), ('d', ['8.6Hz'], '1H', 8.01, 8.01), ('dd', ['7.6Hz', '4.9Hz'], '1H', 7.14, 7.14), ('d', ['2.2Hz'], '1H', 6.97, 6.97), ('dd', ['8.6Hz', '2.2Hz'], '1H', 6.83, 6.83), ('s', [], '3H', 3.85, 3.85)]
10
8
10
10.1002_adsc.202200127
COc1ccc2c(c1)[nH]c1ncccc12
16
16
[0.12040566 0.50703129 0.29355781 0.56171879]
[0.31095588 0.50781254 0.87874031 0.57734379]
13C NMR
101 MHz
DMSO-d6
159.1, 152.1, 144.3, 140.3, 127.1, 122.1, 115.5, 114.9, 113.9, 108.6, 94.7, 55.3
null
[(159.1, None, None), (152.1, None, None), (144.3, None, None), (140.3, None, None), (127.1, None, None), (122.1, None, None), (115.5, None, None), (114.9, None, None), (113.9, None, None), (108.6, None, None), (94.7, None, None), (55.3, None, None)]
12
12
12
10.1002_adsc.202200127
O(c1ccc2[nH]c3ncccc3c2c1)C(F)(F)F
16
16
[0.12123413 0.83359381 0.28554919 0.90078126]
[0.30267108 0.83281253 0.87818797 0.90468751]
1H NMR
500 MHz
DMSO-d6
12.04 (s, 1 H), 8.61 (dd, J = 7.8, 1.6 Hz, 1 H), 8.47 (dd, J = 4.8, 1.6 Hz, 1 H), 8.25 (s, 1 H), 7.58 (d, J = 8.8 Hz, 1 H), 7.44 (dd, J = 8.8, 1.6 Hz, 1 H), 7.24 (dd, J = 7.8, 4.8 Hz, 1 H)
null
[('s', [], '1H', 12.04, 12.04), ('dd', ['7.8Hz', '1.6Hz'], '1H', 8.61, 8.61), ('dd', ['4.8Hz', '1.6Hz'], '1H', 8.47, 8.47), ('s', [], '1H', 8.25, 8.25), ('d', ['8.8Hz'], '1H', 7.58, 7.58), ('dd', ['8.8Hz', '1.6Hz'], '1H', 7.44, 7.44), ('dd', ['7.8Hz', '4.8Hz'], '1H', 7.24, 7.24)]
7
7
7
10.1002_adsc.202200127
O(c1ccc2[nH]c3ncccc3c2c1)C(F)(F)F
16
16
[0.12123413 0.83359381 0.28554919 0.90078126]
[0.30267108 0.83281253 0.87818797 0.90468751]
13C NMR
126 MHz
DMSO-d6
152.6, 147.1, 141.6 (q, J = 2.0 Hz), 137.3, 129.3, 120.8, 120.5 (q, J = 255 Hz), 120.1, 115.3, 114.9, 114.2, 112.3
null
[(152.6, None, None), (147.1, None, None), (141.6, 'q', 2.0), (137.3, None, None), (129.3, None, None), (120.8, None, None), (120.5, 'q', 255.0), (120.1, None, None), (115.3, None, None), (114.9, None, None), (114.2, None, None), (112.3, None, None)]
12
12
12
10.1002_adsc.202200127
Clc1ccc2c(n1)[nH]c1ccccc21
17
17
[0.12261493 0.39921878 0.27892136 0.45390628]
[0.11833446 0.52031253 0.42639065 0.53671877]
1H NMR
500 MHz
DMSO-d6
12.04 (s, 1H), 8.55 (d, J = 8.0 Hz, 1H), 8.17 (d, J = 7.8 Hz, 1H), 7.52 (d, J = 8.0 Hz, 1H), 7.50-7.46 (m, 1H), 7.28-7.24 (m, 2H)
null
[('s', [], '1H', 12.04, 12.04), ('d', ['8.0Hz'], '1H', 8.55, 8.55), ('d', ['7.8Hz'], '1H', 8.17, 8.17), ('d', ['8.0Hz'], '1H', 7.52, 7.52), ('m', [], '1H', 7.5, 7.46), ('m', [], '2H', 7.28, 7.24)]
7
7
7
10.1002_adsc.202200127
Clc1ccc2c(n1)[nH]c1ccccc21
17
17
[0.12261493 0.39921878 0.27892136 0.45390628]
[0.11833446 0.52031253 0.42639065 0.53671877]
13C NMR
126 MHz
DMSO-d6
151.0, 146.2, 138.8, 131.4, 126.9, 121.3, 120.1, 119.9, 114.5, 114.2, 111.6
null
[(151.0, None, None), (146.2, None, None), (138.8, None, None), (131.4, None, None), (126.9, None, None), (121.3, None, None), (120.1, None, None), (119.9, None, None), (114.5, None, None), (114.2, None, None), (111.6, None, None)]
11
11
11
10.1002_adsc.202200127
Fc1ccc2c(n1)[nH]c1ccccc12
17
18
[0.12233877 0.74765631 0.27008423 0.80234381]
[0.11709173 0.08730469 0.87818797 0.13984376]
1H NMR
400 MHz
DMSO-d6
12.00 (br. s, 1 H), 8.65 (t, J = 8.2 Hz, 1 H), 8.14 (dt, J = 7.8, 0.9 Hz, 1 H), 7.51 (dt, J = 8.2, 1.0 Hz, 1 H), 7.44 (ddd, J = 8.2, 7.1, 1.2 Hz, 1 H), 7.25 (ddd, J = 8.0, 7.1, 1.1 Hz, 1 H), 6.93 (dd, J = 8.2, 1.0 Hz, 1 H)
null
[('brs', [], '1H', 12.0, 12.0), ('t', ['8.2Hz'], '1H', 8.65, 8.65), ('dt', ['7.8Hz', '0.9Hz'], '1H', 8.14, 8.14), ('dt', ['8.2Hz', '1.0Hz'], '1H', 7.51, 7.51), ('ddd', ['8.2Hz', '7.1Hz', '1.2Hz'], '1H', 7.44, 7.44), ('ddd', ['8.0Hz', '7.1Hz', '1.1Hz'], '1H', 7.25, 7.25), ('dd', ['8.2Hz', '1.0Hz'], '1H', 6.93, 6.93)]
7
7
7
10.1002_adsc.202200127
Fc1ccc2c(n1)[nH]c1ccccc12
17
18
[0.12233877 0.74765631 0.27008423 0.80234381]
[0.11709173 0.08730469 0.87818797 0.13984376]
13C NMR
126 MHz
DMSO-d6
161.3 (d, J = 235 Hz), 149.3 (d, J = 19.3 Hz), 138.6 (d, J = 2.4 Hz), 133.5 (d, J = 9.7 Hz), 126.1, 120.7, 120.2, 120.0, 113.1 (d, J = 3.2 Hz), 111.5, 99.5 (d, J = 38.4 Hz)
null
[(161.3, 'd', 235.0), (149.3, 'd', 19.3), (138.6, 'd', 2.4), (133.5, 'd', 9.7), (126.1, None, None), (120.7, None, None), (120.2, None, None), (120.0, None, None), (113.1, 'd', 3.2), (111.5, None, None), (99.5, 'd', 38.4)]
11
11
11
10.1002_adsc.202200127
Cc1ccc2c(c1)[nH]c1nc(F)ccc12
18
18
[0.12206261 0.3433594 0.30791814 0.39726565]
[0.11847253 0.46562503 0.27008423 0.47968754]
1H NMR
300 MHz
DMSO-d6
11.88 (br. s, 1H), 8.56 (t, J = 8.1 Hz, 1H), 8.00 (d, J = 8.0 Hz, 1H), 7.30 (s, 1H), 7.07 (d, J = 8.0 Hz, 1H), 6.88 (d, J = 8.2 Hz, 1H), 2.47 (s, 3H)
null
[('brs', [], '1H', 11.88, 11.88), ('t', ['8.1Hz'], '1H', 8.56, 8.56), ('d', ['8.0Hz'], '1H', 8.0, 8.0), ('s', [], '1H', 7.3, 7.3), ('d', ['8.0Hz'], '1H', 7.07, 7.07), ('d', ['8.2Hz'], '1H', 6.88, 6.88), ('s', [], '3H', 2.47, 2.47)]
9
7
9
10.1002_adsc.202200127
Cc1ccc2c(c1)[nH]c1nc(F)ccc12
18
18
[0.12206261 0.3433594 0.30791814 0.39726565]
[0.11847253 0.46562503 0.27008423 0.47968754]
13C NMR
126 MHz
DMSO-d6
161.1 (d, J = 234 Hz), 149.4 (d, J = 19.1 Hz), 139.1 (d, J = 2.3 Hz), 135.8 (s), 132.9 (t, J = 8.6 Hz), 121.5, 120.4 (d, J = 7.2 Hz), 117.9, 113.2 (d, J = 3.2 Hz), 111.5, 99.2 (d, J = 38.3 Hz), 21.7
null
[(161.1, 'd', 234.0), (149.4, 'd', 19.1), (139.1, 'd', 2.3), (135.8, None, None), (132.9, 't', 8.6), (121.5, None, None), (120.4, 'd', 7.2), (117.9, None, None), (113.2, 'd', 3.2), (111.5, None, None), (99.2, 'd', 38.3), (21.7, None, None)]
12
12
12
10.1002_adsc.202200127
Fc1ccc2c(n1)[nH]c1cc(Cl)ccc12
18
18
[0.12233877 0.72890626 0.30129029 0.78359376]
[0.11930102 0.87500007 0.87708339 0.90937504]
1H NMR
500 MHz
DMSO-d6
12.17 (s, 1H), 8.68 (t, J = 8.1 Hz, 1H), 8.17 (d, J = 8.4 Hz, 1H), 7.52 (d, J = 1.7 Hz, 1H), 7.29 (dd, J = 8.3, 1.8 Hz, 1H), 6.98 (d, J = 8.3 Hz, 1H)
null
[('s', [], '1H', 12.17, 12.17), ('t', ['8.1Hz'], '1H', 8.68, 8.68), ('d', ['8.4Hz'], '1H', 8.17, 8.17), ('d', ['1.7Hz'], '1H', 7.52, 7.52), ('dd', ['8.3Hz', '1.8Hz'], '1H', 7.29, 7.29), ('d', ['8.3Hz'], '1H', 6.98, 6.98)]
6
6
6
10.1002_adsc.202200127
Fc1ccc2c(n1)[nH]c1cc(Cl)ccc12
18
18
[0.12233877 0.72890626 0.30129029 0.78359376]
[0.11930102 0.87500007 0.87708339 0.90937504]
13C NMR
126 MHz
DMSO-d6
161.5 (d, J = 236 Hz), 149.7 (d, J = 19.2 Hz), 139.3 (d, J = 2.2 Hz), 134.0 (d, J = 9.9 Hz), 130.4, 122.3, 120.3, 119.1, 112.6 (d, J = 3.2 Hz), 111.2, 100.3 (d, J = 38.4 Hz)
null
[(161.5, 'd', 236.0), (149.7, 'd', 19.2), (139.3, 'd', 2.2), (134.0, 'd', 9.9), (130.4, None, None), (122.3, None, None), (120.3, None, None), (119.1, None, None), (112.6, 'd', 3.2), (111.2, None, None), (100.3, 'd', 38.4)]
11
11
11
10.1002_adsc.202200127
Fc1ccc2[nH]c3nc(F)ccc3c2c1
19
19
[0.12206261 0.28242188 0.28168296 0.34960941]
[0.1187487 0.40234379 0.40816413 0.41640626]
1H NMR
400 MHz
DMSO-d6
12.06 (br. s, 1H), 8.67 (t, J = 8.1 Hz, 1H), 8.01 (dd, J = 9.2, 1.9 Hz, 1H), 7.50 (dd, J = 8.7, 4.4 Hz, 1H), 7.29 (td, J = 9.3, 2.3 Hz, 1H), 6.94 (d, J = 8.2 Hz, 1H)
null
[('brs', [], '1H', 12.06, 12.06), ('t', ['8.1Hz'], '1H', 8.67, 8.67), ('dd', ['9.2Hz', '1.9Hz'], '1H', 8.01, 8.01), ('dd', ['8.7Hz', '4.4Hz'], '1H', 7.5, 7.5), ('td', ['9.3Hz', '2.3Hz'], '1H', 7.29, 7.29), ('d', ['8.2Hz'], '1H', 6.94, 6.94)]
6
6
6
10.1002_adsc.202200127
Fc1ccc2[nH]c3nc(F)ccc3c2c1
19
19
[0.12206261 0.28242188 0.28168296 0.34960941]
[0.1187487 0.40234379 0.40816413 0.41640626]
13C NMR
126 MHz
DMSO-d6
161.7 (d, J = 236 Hz), 157.1 (d, J = 234 Hz), 150.1 (d, J = 19.4 Hz), 135.1, 134.3 (d, J = 10.1 Hz), 120.8 (d, J = 10.2 Hz), 113.8 (d, J = 25.3 Hz), 113.0 (t, J = 3.6 Hz), 112.6 (d, J = 9.2 Hz), 106.6 (d, J = 24.3 Hz), 99.8 (d, J = 38.6 Hz)
null
[(161.7, 'd', 236.0), (157.1, 'd', 234.0), (150.1, 'd', 19.4), (135.1, None, None), (134.3, 'd', 10.1), (120.8, 'd', 10.2), (113.8, 'd', 25.3), (113.0, 't', 3.6), (112.6, 'd', 9.2), (106.6, 'd', 24.3), (99.8, 'd', 38.6)]
11
11
11
10.1002_adsc.202200127
O(c1ccc2[nH]c3nc(F)ccc3c2c1)C
19
19
[0.12206261 0.68593751 0.30791814 0.75312504]
[0.32586852 0.68515631 0.87818797 0.75625001]
1H NMR
400 MHz
DMSO-d6
11.81 (s, 1 H), 8.61 (t, J = 8.2 Hz, 1 H), 7.73 (d, J = 2.5 Hz, 1 H), 7.41 (d, J = 8.8 Hz, 1 H), 7.07 (dd, J = 8.8, 2.5 Hz, 1 H), 6.87 (d, J = 8.2 Hz, 1 H), 3.84 (s, 3 H)
null
[('s', [], '1H', 11.81, 11.81), ('t', ['8.2Hz'], '1H', 8.61, 8.61), ('d', ['2.5Hz'], '1H', 7.73, 7.73), ('d', ['8.8Hz'], '1H', 7.41, 7.41), ('dd', ['8.8Hz', '2.5Hz'], '1H', 7.07, 7.07), ('d', ['8.2Hz'], '1H', 6.87, 6.87), ('s', [], '3H', 3.84, 3.84)]
9
7
9
10.1002_adsc.202200127
O(c1ccc2[nH]c3nc(F)ccc3c2c1)C
19
19
[0.12206261 0.68593751 0.30791814 0.75312504]
[0.32586852 0.68515631 0.87818797 0.75625001]
13C NMR
101 MHz
DMSO-d6
161.3 (d, J = 235 Hz), 153.9, 149.6 (d, J = 19.3 Hz), 133.6 (d, J = 9.9 Hz), 133.2 (d, J = 2.5 Hz), 120.7, 115.2, 113.2 (d, J = 3.1 Hz), 112.3, 103.6, 99.1 (d, J = 38.6 Hz), 55.6
null
[(161.3, 'd', 235.0), (153.9, None, None), (149.6, 'd', 19.3), (133.6, 'd', 9.9), (133.2, 'd', 2.5), (120.7, None, None), (115.2, None, None), (113.2, 'd', 3.1), (112.3, None, None), (103.6, None, None), (99.1, 'd', 38.6), (55.6, None, None)]
12
12
12
10.1002_adsc.202200127
Cc1cnc2[nH]c3cc(Cl)ccc3c2c1
21
21
[0.12233877 0.11464844 0.30156646 0.18222657]
[0.31896452 0.1140625 0.87818797 0.18417969]
1H NMR
500 MHz
DMSO-d6
11.78 (s, 1H), 8.33 (s, 1H), 8.28 (s, 1H), 8.12 (d, J = 8.3 Hz, 1H), 7.47 (d, J = 1.6 Hz, 1H), 7.21 (dd, J = 8.3, 1.8 Hz, 1H), 2.44 (s, 3H)
null
[('s', [], '1H', 11.78, 11.78), ('s', [], '1H', 8.33, 8.33), ('s', [], '1H', 8.28, 8.28), ('d', ['8.3Hz'], '1H', 8.12, 8.12), ('d', ['1.6Hz'], '1H', 7.47, 7.47), ('dd', ['8.3Hz', '1.8Hz'], '1H', 7.21, 7.21), ('s', [], '3H', 2.44, 2.44)]
9
7
9
10.1002_adsc.202200127
Cc1cnc2[nH]c3cc(Cl)ccc3c2c1
21
21
[0.12233877 0.11464844 0.30156646 0.18222657]
[0.31896452 0.1140625 0.87818797 0.18417969]
13C NMR
126 MHz
DMSO-d6
150.7, 147.0, 139.8, 130.7, 128.8, 124.2, 122.6, 119.4, 119.1, 114.4, 110.8, 18.0
null
[(150.7, None, None), (147.0, None, None), (139.8, None, None), (130.7, None, None), (128.8, None, None), (124.2, None, None), (122.6, None, None), (119.4, None, None), (119.1, None, None), (114.4, None, None), (110.8, None, None), (18.0, None, None)]
12
12
12
10.1002_adsc.202200127
c1ccc2c(c1)[nH]c1cnccc21
21
21
[0.12233877 0.45703129 0.24826762 0.51171879]
[0.20656749 0.45781253 0.87818797 0.54531251]
1H NMR
400 MHz
DMSO-d6
11.60 (s, 1H), 8.90 (s, 1H), 8.34 (d, J = 5.2 Hz, 1H), 8.23 (d, J = 7.9 Hz, 1H), 8.10 (d, J = 5.2 Hz, 1H), 7.60 (d, J = 8.2 Hz, 1H), 7.54 (t, J = 7.6 Hz, 1H), 7.24 (t, J = 7.4 Hz, 1H)
null
[('s', [], '1H', 11.6, 11.6), ('s', [], '1H', 8.9, 8.9), ('d', ['5.2Hz'], '1H', 8.34, 8.34), ('d', ['7.9Hz'], '1H', 8.23, 8.23), ('d', ['5.2Hz'], '1H', 8.1, 8.1), ('d', ['8.2Hz'], '1H', 7.6, 7.6), ('t', ['7.6Hz'], '1H', 7.54, 7.54), ('t', ['7.4Hz'], '1H', 7.24, 7.24)]
8
8
8
10.1002_adsc.202200127
c1ccc2c(c1)[nH]c1cnccc21
21
21
[0.12233877 0.45703129 0.24826762 0.51171879]
[0.20656749 0.45781253 0.87818797 0.54531251]
13C NMR
101 MHz
DMSO-d6
140.5, 138.1, 136.0, 134.0, 128.1, 127.4, 121.8, 120.6, 119.2, 114.6, 111.9
null
[(140.5, None, None), (138.1, None, None), (136.0, None, None), (134.0, None, None), (128.1, None, None), (127.4, None, None), (121.8, None, None), (120.6, None, None), (119.2, None, None), (114.6, None, None), (111.9, None, None)]
11
11
11
10.1002_adsc.202200127
O(c1ccc2c(c1)[nH]c1c(C)nccc21)C
21
21
[0.12233877 0.78046879 0.30377574 0.83515629]
[0.32089764 0.78085943 0.87874031 0.85000001]
1H NMR
500 MHz
DMSO-d6
11.55 (s, 1H), 8.17 (d, J = 5.4 Hz, 1H), 8.08 (d, J = 8.7 Hz, 1H), 7.87 (d, J = 5.4 Hz, 1H), 7.02 (d, J = 2.1 Hz, 1H), 6.86 (dd, J = 8.7, 2.2 Hz, 1H), 3.88 (s, 3H), 2.74 (s, 3H)
null
[('s', [], '1H', 11.55, 11.55), ('d', ['5.4Hz'], '1H', 8.17, 8.17), ('d', ['8.7Hz'], '1H', 8.08, 8.08), ('d', ['5.4Hz'], '1H', 7.87, 7.87), ('d', ['2.1Hz'], '1H', 7.02, 7.02), ('dd', ['8.7Hz', '2.2Hz'], '1H', 6.86, 6.86), ('s', [], '3H', 3.88, 3.88), ('s', [], '3H', 2.74, 2.74)]
12
8
12
10.1002_adsc.202200127
O(c1ccc2c(c1)[nH]c1c(C)nccc21)C
21
21
[0.12233877 0.78046879 0.30377574 0.83515629]
[0.32089764 0.78085943 0.87874031 0.85000001]
13C NMR
126 MHz
DMSO-d6
160.4, 142.3, 140.8, 136.8, 134.5, 127.7, 122.8, 114.7 112.2, 109.4, 94.6, 55.4, 19.9
null
[(160.4, None, None), (114.7, None, None), (142.3, None, None), (140.8, None, None), (136.8, None, None), (134.5, None, None), (127.7, None, None), (122.8, None, None), (112.2, None, None), (109.4, None, None), (94.6, None, None), (55.4, None, None), (19.9, None, None)]
13
13
13
10.1002_adsc.202200127
Fc1cncc2[nH]c3ccccc3c12
22
22
[0.1222007 0.30781251 0.24757722 0.38203126]
[0.26290409 0.30546878 0.87818797 0.40312503]
1H NMR
400 MHz
DMSO-d6
11.99 (br. s, 1H), 8.79 (d, J = 2.6 Hz, 1H), 8.29 (s, 1H), 8.14 (d, J = 7.9 Hz, 1H), 7.66 (d, J = 8.2 Hz, 1H), 7.61 (t, J = 7.6 Hz, 1H), 7.31 (t, J = 7.4 Hz, 1H)
null
[('brs', [], '1H', 11.99, 11.99), ('d', ['2.6Hz'], '1H', 8.79, 8.79), ('s', [], '1H', 8.29, 8.29), ('d', ['7.9Hz'], '1H', 8.14, 8.14), ('d', ['8.2Hz'], '1H', 7.66, 7.66), ('t', ['7.6Hz'], '1H', 7.61, 7.61), ('t', ['7.4Hz'], '1H', 7.31, 7.31)]
7
7
7
10.1002_adsc.202200127
Fc1cncc2[nH]c3ccccc3c12
22
22
[0.1222007 0.30781251 0.24757722 0.38203126]
[0.26290409 0.30546878 0.87818797 0.40312503]
13C NMR
126 MHz
DMSO-d6
154.3 (d, J = 256 Hz), 140.2, 138.2 (d, J = 7.1 Hz), 130.7 (d, J = 3.4 Hz), 128.5, 124.7 (d, J = 20.9 Hz), 123.1 (t, J = 3.5 Hz), 120.2, 117.7 (d, J = 1.3 Hz), 115.6 (d, J = 17.8 Hz), 112.3
null
[(154.3, 'd', 256.0), (140.2, None, None), (138.2, 'd', 7.1), (130.7, 'd', 3.4), (128.5, None, None), (124.7, 'd', 20.9), (123.1, 't', 3.5), (120.2, None, None), (117.7, 'd', 1.3), (115.6, 'd', 17.8), (112.3, None, None)]
11
11
11
10.1002_adsc.202200127
Fc1cncc2[nH]c3ccc(Cl)cc3c12
22
22
[0.12261493 0.73515628 0.26373258 0.81093751]
[0.28168296 0.73515628 0.87818797 0.82578131]
1H NMR
400 MHz
DMSO-d6
12.16 (s, 1H), 8.82 (d, J = 2.0 Hz, 1H), 8.32 (s, 1H), 8.11 (s, 1H), 7.70 (d, J = 8.8 Hz, 1H), 7.63 (dd, J = 8.8, 1.7 Hz, 1H)
null
[('s', [], '1H', 12.16, 12.16), ('d', ['2.0Hz'], '1H', 8.82, 8.82), ('s', [], '1H', 8.32, 8.32), ('s', [], '1H', 8.11, 8.11), ('d', ['8.8Hz'], '1H', 7.7, 7.7), ('dd', ['8.8Hz', '1.7Hz'], '1H', 7.63, 7.63)]
6
6
6
10.1002_adsc.202200127
Fc1cncc2[nH]c3ccc(Cl)cc3c12
22
22
[0.12261493 0.73515628 0.26373258 0.81093751]
[0.28168296 0.73515628 0.87818797 0.82578131]
13C NMR
126 MHz
DMSO-d6
154.1 (d, J = 257 Hz), 138.7, 138.5 (d, J = 6.5 Hz), 131.2 (d, J = 3.5 Hz), 128.5, 124.9 (d, J = 20.6 Hz), 124.3, 122.2 (d, J = 2.2 Hz), 118.7, 114.8 (d, J = 17.8 Hz), 114.0
null
[(154.1, 'd', 257.0), (138.7, None, None), (138.5, 'd', 6.5), (131.2, 'd', 3.5), (128.5, None, None), (124.9, 'd', 20.6), (124.3, None, None), (122.2, 'd', 2.2), (118.7, None, None), (114.8, 'd', 17.8), (114.0, None, None)]
11
11
11
10.1002_adsc.202200127
Fc1nccc2c1[nH]c1ccccc21
23
23
[0.12206261 0.33496097 0.24826762 0.39003908]
[0.1756376 0.33593754 0.87763573 0.44531254]
1H NMR
500 MHz
DMSO-d6
8.84 (s, 1H), 7.62 (d, J = 4.8 Hz, 1H), 7.38-7.34 (m, 1H), 7.24 (d, J = 8.0 Hz, 1H), 7.10-7.05 (m, 2H), 6.30-6.22 (m, 1H)
null
[('s', [], '1H', 8.84, 8.84), ('d', ['4.8Hz'], '1H', 7.62, 7.62), ('m', [], '1H', 7.38, 7.34), ('d', ['8.0Hz'], '1H', 7.24, 7.24), ('m', [], '2H', 7.1, 7.05), ('m', [], '1H', 6.3, 6.22)]
7
7
7
10.1002_adsc.202200127
O(c1ccc2c(c1)[nH]c1c(F)nccc12)C
24
24
[0.12206261 0.31875001 0.29935717 0.37382815]
[0.31675524 0.31914065 0.87818797 0.38945315]
1H NMR
500 MHz
DMSO-d6
8.76 (s, 1H), 7.59 (d, J = 4.7 Hz, 1H), 6.96 (d, J = 8.4 Hz, 1H), 6.77 (d, J = 2.0 Hz, 1H), 6.68 (dd, J = 8.4, 2.2 Hz, 1H), 6.23 (d, J = 2.2 Hz, 1H), 3.78 (s, 3H)
null
[('s', [], '1H', 8.76, 8.76), ('d', ['4.7Hz'], '1H', 7.59, 7.59), ('d', ['8.4Hz'], '1H', 6.96, 6.96), ('d', ['2.0Hz'], '1H', 6.77, 6.77), ('dd', ['8.4Hz', '2.2Hz'], '1H', 6.68, 6.68), ('d', ['2.2Hz'], '1H', 6.23, 6.23), ('s', [], '3H', 3.78, 3.78)]
9
7
9
10.1002_adsc.202200127
O(c1ccc2c(c1)[nH]c1c(F)nccc12)C
24
24
[0.12206261 0.31875001 0.29935717 0.37382815]
[0.31675524 0.31914065 0.87818797 0.38945315]
13C NMR
126 MHz
DMSO-d6
159.7, 147.1 (d, J = 259 Hz), 144.9 (d, J = 6.7 Hz), 142.5, 141.1, 134.8 (d, J = 7.8 Hz), 130.7, 119.2, 117.8, 109.1, 108.2, 55.1
null
[(159.7, None, None), (147.1, 'd', 259.0), (144.9, 'd', 6.7), (142.5, None, None), (141.1, None, None), (134.8, 'd', 7.8), (130.7, None, None), (119.2, None, None), (117.8, None, None), (109.1, None, None), (108.2, None, None), (55.1, None, None)]
12
12
12
10.1002_adsc.202400680
O=S(=O)(F)c1cccc(S(=O)(=O)F)c1
2
2
[0.60755148 0.47109376 0.72685246 0.52109377]
[0.11819637 0.5542969 0.87818797 0.64570317]
1H NMR
400 MHz
CDCl3
8.65 (t, J = 1.8 Hz, 1H), 8.42 (dd, J = 8.0, 1.8 Hz, 2H), 7.99 (t, J = 8.0 Hz, 1H)
null
[('t', ['1.8Hz'], '1H', 8.65, 8.65), ('dd', ['8.0Hz', '1.8Hz'], '2H', 8.42, 8.42), ('t', ['8.0Hz'], '1H', 7.99, 7.99)]
4
3
4
10.1002_adsc.202400680
O=S(=O)(F)c1cccc(S(=O)(=O)F)c1
2
2
[0.60755148 0.47109376 0.72685246 0.52109377]
[0.11819637 0.5542969 0.87818797 0.64570317]
13C NMR
101 MHz
CDCl3
135.5 (d, J = 28 Hz), 134.9, 131.8, 128.7
null
[(135.5, 'd', 28.0), (134.9, None, None), (131.8, None, None), (128.7, None, None)]
6
4
4
10.1002_adsc.202400680
O=S(=O)(F)c1cccc(S(=O)(=O)F)c1
2
2
[0.60755148 0.47109376 0.72685246 0.52109377]
[0.11819637 0.5542969 0.87818797 0.64570317]
19F NMR
377 MHz
CDCl3
66.6
null
[(66.6, None, None)]
2
1
1
10.1002_adsc.202400680
O=S(=O)(F)c1cc(S(=O)(=O)F)cc(S(=O)(=O)F)c1
3
3
[0.44296026 0.10253907 0.56391821 0.18574219]
[0.11819637 0.21640625 0.87818797 0.38632815]
1H NMR
400 MHz
CDCl3
8.96 (s, 3H)
null
[('s', [], '3H', 8.96, 8.96)]
3
1
3
10.1002_adsc.202400680
O=S(=O)(F)c1cc(S(=O)(=O)F)cc(S(=O)(=O)F)c1
3
3
[0.44296026 0.10253907 0.56391821 0.18574219]
[0.11819637 0.21640625 0.87818797 0.38632815]
13C NMR
101 MHz
CDCl3
137.7 (d, J = 30.3 Hz), 134.36
null
[(137.7, 'd', 30.3), (134.36, None, None)]
6
2
2
10.1002_adsc.202400680
O=S(=O)(F)c1cc(S(=O)(=O)F)cc(S(=O)(=O)F)c1
3
3
[0.44296026 0.10253907 0.56391821 0.18574219]
[0.11819637 0.21640625 0.87818797 0.38632815]
19F NMR
377 MHz
CDCl3
67.82
null
[(67.82, None, None)]
3
1
1
10.1002_adsc.202400680
COc1ccc(CCN=[N+]=[N-])cc1
3
3
[0.11985333 0.76562507 0.27395048 0.80625006]
[0.11819637 0.81171879 0.87874031 0.90390631]
1H NMR
400 MHz
CDCl3
7.19-7.08 (m, 2H), 6.93-6.80 (m, 2H), 3.80 (s, 3H), 3.47 (t, J = 7.2 Hz, 2H), 2.84 (t, J = 7.2 Hz, 2H)
null
[('m', [], '2H', 7.19, 7.08), ('m', [], '2H', 6.93, 6.8), ('s', [], '3H', 3.8, 3.8), ('t', ['7.2Hz'], '2H', 3.47, 3.47), ('t', ['7.2Hz'], '2H', 2.84, 2.84)]
11
5
11
10.1002_adsc.202400680
COc1ccc(CCN=[N+]=[N-])cc1
3
3
[0.11985333 0.76562507 0.27395048 0.80625006]
[0.11819637 0.81171879 0.87874031 0.90390631]
13C NMR
101 MHz
CDCl3
158.7, 130.2, 129.8, 114.2, 55.4, 52.8, 34.6
null
[(158.7, None, None), (130.2, None, None), (129.8, None, None), (114.2, None, None), (55.4, None, None), (52.8, None, None), (34.6, None, None)]
9
7
7
10.1002_adsc.202400680
N(CCc1ccccc1)=[N+]=[N-]
4
4
[0.12068181 0.10234375 0.22838413 0.13769532]
[0.11819637 0.14277344 0.87818797 0.23515626]
1H NMR
400 MHz
CDCl3
7.24 (dd, J = 8.1, 6.5 Hz, 2H), 7.20-7.10 (m, 3H), 3.42 (t, J = 7.3 Hz, 2H), 2.82 (t, J = 7.3 Hz, 2H)
null
[('dd', ['8.1Hz', '6.5Hz'], '2H', 7.24, 7.24), ('m', [], '3H', 7.2, 7.1), ('t', ['7.3Hz'], '2H', 3.42, 3.42), ('t', ['7.3Hz'], '2H', 2.82, 2.82)]
9
5
9
10.1002_adsc.202400680
N(CCc1ccccc1)=[N+]=[N-]
4
4
[0.12068181 0.10234375 0.22838413 0.13769532]
[0.11819637 0.14277344 0.87818797 0.23515626]
13C NMR
101 MHz
CDCl3
138.12, 128.9, 128.8, 126.9, 52.6, 35.5
null
[(138.12, None, None), (128.9, None, None), (128.8, None, None), (126.9, None, None), (52.6, None, None), (35.5, None, None)]
8
6
6
10.1002_adsc.202400680
N(=[N+]=[N-])CCC1C=CC(Br)=CC=1
4
4
[0.12040566 0.26640626 0.25848553 0.30664062]
[0.11819637 0.31132815 0.87818797 0.41914063]
1H NMR
400 MHz
CDCl3
7.50-7.40 (m, 2H), 7.17-7.05 (m, 2H), 3.49 (t, J = 7.1 Hz, 2H), 2.85 (t, J = 7.1 Hz, 2H)
null
[('m', [], '2H', 7.5, 7.4), ('m', [], '2H', 7.17, 7.05), ('t', ['7.1Hz'], '2H', 3.49, 3.49), ('t', ['7.1Hz'], '2H', 2.85, 2.85)]
8
4
8
10.1002_adsc.202400680
N(=[N+]=[N-])CCC1C=CC(Br)=CC=1
4
4
[0.12040566 0.26640626 0.25848553 0.30664062]
[0.11819637 0.31132815 0.87818797 0.41914063]
13C NMR
101 MHz
CDCl3
137.2, 131.9, 130.6, 120.8, 52.3, 34.9
null
[(137.2, None, None), (131.9, None, None), (130.6, None, None), (120.8, None, None), (52.3, None, None), (34.9, None, None)]
8
6
6