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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
One example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution is here: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this: The Conquest of Melilla occurred in September 1497, when a fleet sent by the Duke of Medina Sidonia seized the north African city of Melilla., as continuation of Reconquest of Mauritania Tingitana During the 15th century the mediterranean cities of the Sultanate of Fez fell in decadence in opposition to cities located in the Atlantic facade, which concentrated most of the economic activity. By the end of the 15th century, the port of Melilla, that had been often disputed between the rulers of Fez and Tlemcen, was nearly abandoned. Plans for the conquest occurred as soon as the Fall of Granada in 1492. Spanish captains Lezcano and Lorenzo Zafra visited the coast of Northern Africa to identify possible locations for the Spanish to overtake, and Melilla was identified as a prime candidate. Melilla was, however, in the Portuguese zone of influence under the terms of the 1479 Treaty of Alcacovaz. At Tordesillas in 1494, King John II of Portugal, the Portuguese ruler agreed to make an exception and permitted the Spanish to attempt the conquest of Melilla. The duke sent Pedro Estopinan who conquered the city virtually without a fight in 1497, as internal conflicts had depleted it of troops, and its defenses were weakened. The Wattasid ruler Muhammad al-Shaykh sent a detachment of cavalrymen to retake control of the city, but they were repulsed by the guns of the Spanish ships.
Solution:
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What happened second: The Conquest of Melilla or Treaty of Alcáçovaz?
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task470_mrqa_question_generation
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instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
James Dargaville (born 25 April 1992) is an Australian rugby union footballer who currently plays as a wing for the Brumbies in Super Rugby.
answer:
What is the position James Dargaville plays in football?
question:
Electronic book publishing has many of the same risks and opportunities as electronic music publishing. By delivering text direct to the user's computer screen, the e-book could cut down costs, and allow creators to deal directly with their audience, bypassing traditional publishers and readers. But it also raises the possibility of mass piracy . Phil Rance, founder and managing director of Online Originals, a London-based e-book publisher, sums it up. "No one wants Napster to happen to books." Indeed, the most popular MP3 have put the frighteners on an industry that generally operates some way behind the "bleeding edge". The Mata Group, a leading US-based market researcher, says publishers are far too concerned about protecting their rights, "We believe all the recent legal control over Napster is like putting a finger in a river that is already overflowing. Publishers need to deal with reality and come up with new ways to develop wide electronic distribution , asking the question: 'How can we use the certainty of wide distribution to our advantage?'" At the moment, most publishers would like to limit the use of e-books to the person who bought them, or to the computer used to download them. If that can be done, e-books become just an extra income stream in a publishing industry that would continue to operate the way it does today, according to Terry Robinson, business manager for Adobe's e-paper group. "If you've cracked digital rights aspect, you've cracked the market," he says. Robert Nichols, Books Director at BOL agrees, "Rights management is absolutely important. Publishers just say that 'until copyright is secure, we're not going to talk'."
answer:
What do publishers care most about e-books?
question:
This was a 12-week randomized, placebo-controlled trial to assess the efficacy of quetiapine monotherapy in the treatment of posttraumatic stress disorder (PTSD). Eighty patients were randomly assigned to treatment with either quetiapine or placebo. The primary outcome measure was the Clinician-Administered PTSD Scale (CAPS). Secondary efficacy measures included the CAPS subscales, the Davidson Trauma Scale, the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impressions (CGI) scales for severity of Illness and improvement, the Hamilton Depression Rating Scale (HAM-D), and the Hamilton Anxiety Rating Scale (HAM-A). Safety measurements included adverse events, vital signs, the Abnormal Involuntary Movement Scale, the Barnes Akathisia Scale, the Simpson-Angus Scale, and the Arizona Sexual Experiences Scale. After a 1-week placebo run-in, quetiapine was started at a daily dosage of 25 mg and increased to a maximum of 800 mg; the average was 258 mg (range, 50-800 mg). Reductions in CAPS total, re-experiencing, and hyperarousal scores were significantly greater for the quetiapine group than for the placebo group. Greater improvements were also observed for quetiapine in scores on the Davidson Trauma Scale, CGI severity and improvement ratings, PANSS positive symptom and general psychopathology subscales, HAM-A, and HAM-D than for placebo. Adverse events were generally mild and expected based on prior studies of quetiapine in this and other patient population. There were no differences in safety measures between groups. Quetiapine monotherapy was efficacious in the treatment of PTSD. These findings suggest quetiapine as a single agent is effective in treating military PTSD.
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Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
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task470_mrqa_question_generation
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
[Q]: The Linth (pronounced (lnt) ''lint'') is a Swiss river that rises near the village of Linthal in the mountains of the canton of Glarus, and eventually flows into the Obersee section of Lake Zurich.
[A]: What river does Linth turn into?
[Q]: Miguel Angel Garcia Tebar (born 26 September 1979), known as Miguel Garcia, is a Spanish retired footballer who played as a defensive midfielder.
[A]: What role does Miguel Ángel García Tébar play in football?
[Q]: Albino Perez (died 8 August 1837) was a Mexican soldier and politician who was appointed Governor of New Mexico.
[A]:
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Which was the position that Albino Pérez held?
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
[Q]: Sr-Vagsy is a former municipality in Sogn og Fjordane county in Norway.
[A]: In which country would you find Sør-Vågsøy?
[Q]: Today, the Eiffel Tower, which serves an important role in television and radio broadcasts, is considered an architectural wonder. It attracts more visitors than any other paid tourist attraction in the world. The Eiffel Tower was designed by the French engineer and bridge builder Alexandre Gustave Eiffel for the Paris Exposition of 1889. The tower is 300 m high and consists of an open iron framework making it the highest manmade structure in the world at the time. It was almost not built. After being awarded the contract to build the tower, Eiffel discovered that the Exposition Committee would only provide about a quarter of the money needed to construct it. Eiffel himself would have to finance the balance. He thought of a deal that would make him a very rich man. He agreed to independently find the people to fund his tower but he wanted to be the only one to control of the tower and he wanted the profits for twenty years. They agreed. To everyone's surprise, including Eiffel, the tower was paid off in the first year. The deal that Eiffel came up with was probably what saved the tower from destruction. A Committee of Three Hundred was formed and they demanded an end to its building. Many members of the committee said, "They have only put up the framework of this monument, It has no skin." Many sculptors and architects protested , in the name of threatened French art and history, about the useless Eiffel Tower, in the heart of their capital. It is built of iron, which is an inferior material, and a single beam of it is unable to support large stresses. That is why the tower appears over-engineered by today's standards. Though, from this very weakness, its simple beauty can be found. If you look at the tower, the structure of it sort of copies the biological cellular structure of a plant.
[A]: What was the Eiffel Tower originally designed for?
[Q]: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an autosomal dominant heart muscle disorder that causes arrhythmia, heart failure, and sudden death. Previously we mapped the genetic locus for the triad of autosomal recessive ARVC, palmoplantar keratoderma, and woolly hair (Naxos disease) to chromosome 17q21, in which the gene for plakoglobin is encoded. This protein is a key component of desmosomes and adherens junctions, and is important for the tight adhesion of many cell types, including those in the heart and skin. We studied 19 individuals with Naxos disease, as well as unaffected family members and unrelated individuals from the neighbouring Greek islands of Naxos and Milos. Gene sequence was determined by reverse transcriptase PCR from RNA isolated from the skin of an affected individual and mutations in other cases were confirmed by restriction-enzyme analysis. A homozygous 2 base pair deletion in the plakoglobin gene was identified only in the 19 affected individuals. This deletion caused a frameshift and premature termination of the protein, which was shown by western blot analysis. 29 clinically unaffected family members were heterozygous for the mutation; 20 unrelated individuals from Naxos and 43 autosomal dominant ARVC probands were homozygous for the normal allele. The finding of a deletion in plakoglobin in ARVC suggests that the proteins involved in cell-cell adhesion play an important part in maintaining myocyte integrity, and when junctions are disrupted, cell death, and fibrofatty replacement occur. Therefore, the discovery of a mutation in a protein with functions in maintaining cell junction integrity has important implications for other dominant forms of ARVC, related cardiomyopathies, and other cutaneous diseases.
[A]:
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Which gene is mutated in a subtype of arrhythmogenic right ventricular cardiomyopathy known as Naxos disease?
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task470_mrqa_question_generation
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Ex Input:
FK506 binding protein 6, also known as FKBP6, is a human gene.
Ex Output:
In what living being can FKBP6 be found?
Ex Input:
In anaesthesia and in the intensive care unit, benzodiazepines have proven safe and effective agents for the induction and maintenance of sedation for a variety of therapeutic goals. However, in these contexts, or in benzodiazepine overdose, it is often desirable to be able to terminate or interrupt sedation without waiting for the effect of the benzodiazepine to become dissipated by normal metabolism and excretion. Flumazenil, a 1,4-imidazobenzodiazepine, is a highly effective, specific benzodiazepine antagonist which is indicated for use when the effect of a benzodiazepine must be attenuated or terminated at short notice. It acts by displacing other benzodiazepines from the receptor site by competitive inhibition. The onset of effect after intravenous administration occurs within 1 to 3 minutes. The optimal dosage is determined for each patient by a dose titration procedure and lies in the range 0.2 to 1.0mg in anaesthesiology, and 0.1 to 2.0mg in intensive care use. Despite its short elimination half-life of around 1 hour, after general anaesthesia or conscious to moderate sedation for short procedures, a single dose of flumazenil is usually sufficient to attain and maintain the desired level of consciousness. After intoxication with high benzodiazepine doses, the duration of effect of a single dose of flumazenil is not expected to exceed 1 hour. In such cases, the period of wakefulness can be prolonged as necessary by repeated low intravenous doses of flumazenil or by infusion (0.1 mg/hour). Flumazenil is well tolerated both systemically and locally. The only adverse events seen with greater frequency after flumazenil compared with placebo were nausea and/or vomiting after general anaesthesia, although the incidence of actual vomiting was not significantly different between the 2 groups. Since these effects were virtually absent in studies of intensive care patients and after sedation for short procedures, and were not seen in tolerability studies in healthy volunteers receiving intravenous bolus doses of up to 100mg, there may be a link between these symptoms and the other agents used in general anaesthesia, some of which have well-known emetic properties. Thus, flumazenil provides a safe and effective means of attenuating or reversing the CNS-depressant effects of benzodiazepines whenever indicated, e.g. following benzodiazepine-induced general anaesthesia, conscious sedation, or after benzodiazepine overdose, either alone or in combination with other agents.(ABSTRACT TRUNCATED AT 400 WORDS)
Ex Output:
Which drug should be used as an antidote in benzodiazepine overdose?
Ex Input:
Associacao Desportiva Bahia de Feira play their home games at Estadio Municipal Alberto Oliveira, nicknamed Estadio Joia da Princesa.
Ex Output:
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In what stadium does Associação Desportiva Bahia de Feira play home games?
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task470_mrqa_question_generation
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Given the task definition, example input & output, solve the new input case.
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Output: In what year did francis, duke of anjou leave the netherlands?
The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
New input case for you: The history of the atom begins around 450 B.C. with a Greek philosopher named Democritus (see Figure 5.7). Democritus wondered what would happen if you cut a piece of matter, such as an apple, into smaller and smaller pieces. He thought that a point would be reached where matter could not be cut into still smaller pieces. He called these "uncuttable" pieces atomos. This is where the modern term atom comes from. Democritus was an important philosopher. However, he was less influential than the Greek philosopher Aristotle, who lived about 100 years after Democritus. Aristotle rejected Democrituss idea of atoms. In fact, Aristotle thought Around 1800, a British chemist named John Dalton revived Democrituss early ideas about the atom. Dalton is pictured in Figure 5.8. He made a living by teaching and just did research in his spare time. Nonetheless, from his research results, he developed one of the most important theories in science. Dalton did many experiments that provided evidence for atoms. For example, he studied the pressure of gases. He concluded that gases must consist of tiny particles in constant motion. Dalton also researched the properties of compounds. He showed that a compound always consists of the same elements in the same ratio. On the other hand, different compounds always consist of different elements or ratios. This can happen, Dalton reasoned, only if elements are made of tiny particles that can combine in an endless variety of ways. From his research, Dalton developed a theory of the atom. You can learn more about Dalton and his research by watching the video at this URL: (9:03). MEDIA Click image to the left or use the URL below. URL: The atomic theory Dalton developed consists of three ideas: All substances are made of atoms. Atoms are the smallest particles of matter. They cannot be divided into smaller particles. They also cannot be created or destroyed. All atoms of the same element are alike and have the same mass. Atoms of different elements are different and have different masses. Atoms join together to form compounds. A given compound always consists of the same kinds of atoms in the same ratio. Daltons theory was soon widely accepted. Most of it is still accepted today. The only part that is no longer accepted is his idea that atoms are the smallest particles. Scientists now know that atoms consist of even smaller particles. Dalton incorrectly thought that atoms are tiny solid particles of matter. He used solid wooden balls to model them. The sketch in the Figure 5.9 shows how Daltons model atoms looked. He made holes in the balls so they could be joined together with hooks. In this way, the balls could be used to model compounds. When later scientists discovered subatomic particles (particles smaller than the atom itself), they realized that Daltons models were too simple. They didnt show that atoms consist of even smaller particles. Models including these smaller particles were later developed. The next major advance in the history of the atom was the discovery of electrons. These were the first subatomic particles to be identified. They were discovered in 1897 by a British physicist named J. J. Thomson. You can learn more about Thomson and his discovery at this online exhibit: . Thomson was interested in electricity. He did experiments in which he passed an electric current through a vacuum tube. The experiments are described in Figure 5.10. Thomsons experiments showed that an electric current consists of flowing, negatively charged particles. Why was this discovery important? Many scientists of Thomsons time thought that electric current consists of rays, like rays of light, and that it is positive rather than negative. Thomsons experiments also showed that the negative particles are all alike and smaller than atoms. Thomson concluded that the negative particles couldnt be fundamental units of matter because they are all alike. Instead, they must be parts of atoms. The negative particles were later named electrons. Thomson knew that atoms are neutral in electric charge. So how could atoms contain negative particles? Thomson thought that the rest of the atom must be positive to cancel out the negative charge. He said that an atom is like
Output:
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In the plum pudding model of the atom, the plums represent
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task470_mrqa_question_generation
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Is it time to kick Russia out of the BRICs ? If so, it may end up sounding like a famous ball-point pen maker-BIC. An argument is being made that Goldman Sach's famous marketing device ,the BRICs, should really be the BICs. "Is Russia really worth the name BRICs?" asks Anders Aslund, senior fellow at the Peterson Institute for International Economics, in an article for Foreigh Policy. Aslund, who is also co-author with Andrew Kuchins of "The Russian Balance Sheet", thinks the Russia of Putin and Medvedev is just not worthy of inclusion alongside Brazil, India and China in the list of future economic powerhouses. He writes: "The country's economic performance has fallen to such a weak level that one must ask whether it has any say at all on the global economy, compared with the other members of its group. I have just returned from Moscow, which is always dull around this season. For the last seven years, Russia has taken very few measures to improve its economy. Instead, the state has been living on oil and gas. " Economically, Aslund has the numbers on his side. The International Monetary Fund figures that the Russian economy will fall by 6.7 percent in 2009, while China will grow 8.5 percent and India 5.4 percent. There is less of a case for Brazil, with a fall of 0.7 percent, but it is still doing far better than Russia. But the BRICs are not just about economy. As is mentioned above, it is a marketing device to encourage investors to focus on the big promising players. From an investment standpoint, it could be argued that Russia is leading the BRICs. Its stock market is up 128 percent this year while around 80 percent is for the other three. At very least, however, Russia's economic underperformance and stock market outperfoumance does suggest it is indeed one of the group.
According to the passage, which country will enjoy the biggest increase in 2009?
Forces deployed to the first Gulf War report more ill health than veterans who did not serve there. Many studies of post-Gulf morbidity are based on relatively small sample sizes and selection bias is often a concern. In a setting where selection bias relating to the ill health of veterans may be reduced, we: i) examined self-reported adult ill health in a large sample of male UK Gulf War veterans and a demographically similar non-deployed comparison group; and ii) explored self-reported ill health among veterans who believed that they had Gulf War syndrome. This study uses data from a retrospective cohort study of reproduction and child health in which a validated postal questionnaire was sent to all UK Gulf War veterans (GWV) and a comparison cohort of Armed Service personnel who were not deployed to the Gulf (NGWV). The cohort for analysis comprises 42,818 males who responded to the questionnaire. We confirmed that GWV report higher rates of general ill health. GWV were significantly more likely to have reported at least one new medical symptom or disease since 1990 than NGWV (61% versus 37%, OR 2.7, 95% CI 2.5-2.8). They were also more likely to report higher numbers of symptoms. The strongest associations were for mood swings (OR 20.9, 95%CI 16.2-27.0), memory loss/lack of concentration (OR 19.6, 95% CI 15.5-24.8), night sweats (OR 9.9, 95% CI 6.5-15.2), general fatigue (OR 9.6, 95% CI 8.3-11.1) and sexual dysfunction (OR 4.6, 95%CI 3.2-6.6). 6% of GWV believed they had Gulf War syndrome (GWS), and this was associated with the highest symptom reporting. Increased levels of reported ill health among GWV were confirmed. This study was the first to use a questionnaire which did not focus specifically on the veterans' symptoms themselves. Nevertheless, the results are consistent with those of other studies of post-Gulf war illness and thus strengthen overall findings in this area of research. Further examination of the mechanisms underlying the reporting of ill health is required.
What memory problems are reported in the " Gulf war syndrome"
Youve probably blown soap bubbles like the child in Figure 4.1. In some ways, the thin film of soap molecules that forms a bubble resembles the cell membrane. Like the soap film, the cell membrane consists of a thin skin of molecules. You can see a model of the cell membrane in Figure below. The molecules that make up the cell membrane are mainly phospholipids. There are two layers of phospholipids. They are arranged so the lipid tails are on the inside of the membrane. They make the interior of the membrane hydrophobic, or "water fearing". The lipid heads point toward the outside of the membrane. The make the outer surfaces of the membrane hydrophilic, or "water loving". Different types of proteins are embedded in the lipid layers. The proteins are needed to help transport many substances across the membrane. The passage of a substance through a cell membrane is called transport. There are two basic ways that transport can occur: passive transport and active transport. For a good video introduction to passive and active transport, click on this link: . MEDIA Click image to the left or use the URL below. URL: Passive transport occurs when a substance passes through the cell membrane without needing any energy to pass through. This happens when a substance moves from an area where it is more concentrated to an area where it is less concentrated. Concentration is the number of particles of a substance in a given volume. Lets say you dissolve a teaspoon of salt in a cup of water. Then you dissolve two teaspoons of salt in another cup of water. The second solution will have a higher concentration of salt. Why does passive transport require no energy? A substance naturally moves from an area of higher to lower concentration. This is known as moving down the concentration gradient. The process is called diffusion. Its a little like a ball rolling down a hill. The ball naturally rolls from a higher to lower position without any added energy. You can see diffusion if you place a few drops of food coloring in a pan of water. Even without shaking or stirring, the food coloring gradually spreads throughout the water in the pan. Some substances can also diffuse through a cell membrane. This can occur in two ways: simple diffusion or facilitated diffusion. Simple diffusion occurs when a substance diffuses through a cell membrane without any help from other molecules. The substance simply passes through tiny spaces in the membrane. It moves from the side of the membrane where it is more concentrated to the side where it is less concentrated. You can see how this happens in Figure 4.2. Substances that cross cell membranes by simple diffusion must squeeze between the lipid molecules in the mem- brane. As a result, the diffusing molecules must be very small. Oxygen (O2 ) and carbon dioxide (CO2 ) are examples of molecules that can cross cell membranes this way. When you breathe in, oxygen is more concentrated in the air in your lungs than it is in your blood. So oxygen diffuses from your lungs to your blood. The reverse happens with carbon dioxide. Carbon dioxide is more concentrated in your blood than it is in the air in your lungs. So carbon dioxide diffuses out of your blood to your lungs. Hydrophilic molecules and very large molecules cant pass through the cell membrane by simple diffusion. They need help to pass through the membrane. The help is provided by proteins called transport proteins. This process is known as facilitated diffusion. There are two types of transport proteins: channel proteins and carrier proteins. They work in different ways. You can see how they work in Figure 4.3. A channel protein forms a tiny hole called a pore in the cell membrane. This allows water or hydrophilic molecules to bypass the hydrophobic interior of the membrane. A carrier protein binds with a diffusing molecule. This causes the carrier protein to change shape. As it does, it carries the molecule across the membrane. This allows large molecules to pass through the cell membrane. Osmosis is the special case of the diffusion of water. Its an important means of transport in cells because the fluid inside and outside cells is mostly water
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_______passage of a substance through a cell membrane from an area of higher to lower concentration that
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TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Alfred Wegener, born in 1880, was a meteorologist and explorer. In 1911, Wegener found a scientific paper that listed identical plant and animal fossils on opposite sides of the Atlantic Ocean. Intrigued, he then searched for and found other cases of identical fossils on opposite sides of oceans. The explanation put out by the scientists of the day was that land bridges had once stretched between these continents. Instead, Wegener pondered the way Africa and South America appeared to fit together like puzzle pieces. Other scientists had suggested that Africa and South America had once been joined, but Wegener was the ideas most dogged supporter. Wegener amassed a tremendous amount of evidence to support his hypothesis that the continents had once been joined. Imagine that youre Wegeners colleague. What sort of evidence would you look for to see if the continents had actually been joined and had moved apart? Here is the main evidence that Wegener and his supporters collected for the continental drift hypothesis: The continents appear to fit together. Ancient fossils of the same species of extinct plants and animals are found in rocks of the same age but are on continents that are now widely separated (Figure 1.1). Wegener proposed that the organisms had lived side by side, but that the lands had moved apart after they were dead and fossilized. His critics suggested that the organisms moved over long-gone land bridges, but Wegener thought that the organisms could not have been able to travel across the oceans. Fossils of the seed fern Glossopteris were too heavy to be carried so far by wind. Mesosaurus was a swimming reptile, but could only swim in fresh water. Cynognathus and Lystrosaurus were land reptiles and were unable to swim. Wegener used fossil evidence to support his continental drift hypothesis. The fos- sils of these organisms are found on lands that are now far apart. Identical rocks, of the same type and age, are found on both sides of the Atlantic Ocean. Wegener said the rocks had formed side by side and that the land had since moved apart. Mountain ranges with the same rock types, structures, and ages are now on opposite sides of the Atlantic Ocean. The Appalachians of the eastern United States and Canada, for example, are just like mountain ranges in eastern Greenland, Ireland, Great Britain, and Norway (Figure 1.2). Wegener concluded that they formed as a single mountain range that was separated as the continents drifted. Grooves and rock deposits left by ancient glaciers are found today on different continents very close to the Equator. This would indicate that the glaciers either formed in the middle of the ocean and/or covered most of the Earth. Today, glaciers only form on land and nearer the poles. Wegener thought that the glaciers were centered over the southern land mass close to the South Pole and the continents moved to their present positions later on. The similarities between the Appalachian and the eastern Greenland mountain ranges are evidences for the continental drift hypothesis. Coral reefs and coal-forming swamps are found in tropical and subtropical environments, but ancient coal seams and coral reefs are found in locations where it is much too cold today. Wegener suggested that these creatures were alive in warm climate zones and that the fossils and coal later drifted to new locations on the continents. Wegener thought that mountains formed as continents ran into each other. This got around the problem of the leading hypothesis of the day, which was that Earth had been a molten ball that bulked up in spots as it cooled (the problem with this idea was that the mountains should all be the same age and they were known not to be). Click image to the left or use the URL below. URL:
SOLUTION: the coast of south america fits closely to this continent like a puzzle piece.
PROBLEM: Munich sincerely invites you to join the 2016 0ktoberfest--the biggest celebration of its kind in Europe. Drink beer by the liter, eat traditional Bavarian food, listen to traditional Bavarian music as well as more up-to-date music, and enjoy yourself with hundreds of other people from all over the world, dancing and singing the hours away. Oktoberfest 2016 begins on Saturday 17th September and runs through to Monday 3rd October 2016. Don't miss the events during Oktoberfest! Grand entry of the Oktoberfest landlords and breweries Date: Saturday, 17th September 2016 Duration: about 45 minutes This is the official prelude to the opening of the Oktoberfest and involves about 1,000 participants, including the landlords' families in decorated carriages, the magnificent horse-drawn drays, waitresses on decorated floats and all the beer tent bands. Oktoberfest Costume and Riflemen-s Parade Date: Sunday, 18th September 2016 Duration:2-2 1/2 hours, about 8000 performers,7 km distance A varied succession of regional costume groups, "troops" in historical uniforms, marching bands, riflemen, thoroughbred horses, oxen, cows, goats, floats displaying typical local traditions and historic carriages all pass by in a 7-kilometer-long procession through the streets of the city center. Open-Air Oktoberfest Music Date: Sunday, 25th September 2016 Place: on the steps of the Bavaria statue At the traditional open-air concert on the second Sunday of the Oktoberfest, all the instruments that make up typical Bavarian wind band music can be heard. The bands from all of the tents come together at the steps under the Bavaria statue to play the most well-known songs and marches of Oktoberfest together while being conducted by distinguished Munich personalities.
SOLUTION: When will visitors see costume soldiers marching on the street?
PROBLEM: Artangel is a London-based arts organisation founded in 1985 by Roger Took.
SOLUTION:
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What is the name of the founder of Artangel?
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Teacher: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Teacher: Now, understand the problem? If you are still confused, see the following example:
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Reason: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this instance: The evolutionarily conserved histone variant H2A.Z has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. Saccharomyces cerevisiae Swr1, a Swi2/Snf2-related ATPase, is the catalytic core of a multisubunit chromatin remodeling enzyme, called the SWR1 complex, that efficiently replaces conventional histone H2A in nucleosomes with histone H2A.Z. Swr1 is required for the deposition of histone H2A.Z at stereotypical promoter locations in vivo, and Swr1 and H2A.Z commonly regulate a subset of yeast genes. Here, we describe an integrated nucleosome assembly-histone replacement system whereby histone exchange by chromatin remodeling activities may be analyzed in vitro. The system demonstrates ATP- and SWR1-complex-dependent replacement of histone H2A for histone H2A.Z on a preassembled nucleosome array. This system may also be adapted to analyze dynamic interactions between chromatin remodeling and modifying enzymes, histone chaperones, and nucleosome substrates containing canonical, variant, or covalently modified histones.
Student:
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Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
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instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
The Yellow River Piano Concerto (simplified Chinese: ; traditional Chinese: ; pinyin: Huang He xiezouqu) is a piano concerto arranged by a collaboration between musicians including Yin Chengzong and Chu Wanghua, and based on the Yellow River Cantata by composer Xian Xinghai.
answer:
What instrument is Yellow River Piano Concerto scored for?
question:
The French Revolution broke out in 1789. At the time France was in a crisis. The government was badly run and people's lives were miserable. King Louis XIV tried to control the national parliament and raise more taxes. But his effort failed. He ordered his troops to Versailles. The people thought that Louis intended to put down the Revolution by force. On July 14, 1789, they stormed and took the Bastille, where political prisoners were kept. Ever since that day, July 14 has been the French National Day. Louis tried to flee the country in 1792, to get support from Austria and Prussia. However, he was caught and put in prison. In September 1792, the monarchy was abolished _ . In the same year, Louis was executed. A few months later his wife, Marie also had her head cut off. The Revolution of France had frightened the other kings of Europe. Armies from Austria and Prussia began to march against France. The French raised republican armies to defend the nation. The Revolution went through a period of terror. Thousands of people lost their lives. In the end, power passed to Napoleon Bonaparte.
answer:
What's this passage about?
question:
Lewy bodies, neuropathological hallmarks of Parkinson's disease and dementia with Lewy bodies, comprise alpha-synuclein filaments and other less defined proteins. Characterization of Lewy body proteins that interact with alpha-synuclein may provide insight into the mechanism of Lewy body formation. Double immunofluorescence labeling and confocal microscopy revealed approximately 80% of cortical Lewy bodies contained microtubule-associated protein 1B (MAP-1B) that overlapped with alpha-synuclein. Lewy bodies were isolated using an immunomagnetic technique from brain tissue of patients dying with dementia with Lewy bodies. Lewy body proteins were resolved by polyacrylamide gel electrophoresis. Immunoblotting confirmed the presence of MAP-1B and alpha-synuclein in purified Lewy bodies. Direct binding studies revealed a high affinity interaction (IC(50) approximately 20 nm) between MAP-1B and alpha-synuclein. The MAP-1B-binding sites were mapped to the last 45 amino acids of the alpha-synuclein C terminus. MAP-1B also bound in vitro assembled alpha-synuclein fibrils. Thus, MAP-1B may be involved in the pathogenesis of Lewy bodies via its interaction with monomeric and fibrillar alpha-synuclein.
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Which is the primary protein component of Lewy bodies?
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
One example is below.
Q: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
A: In what year did francis, duke of anjou leave the netherlands?
Rationale: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Q: Penobscot tribal chiefs expressed a willingness to enter peace talks with Lieutenant Governor Dummer in December 1724. They were opposed in this by French authorities, who continued to encourage the conflict, but Massachusetts Lieutenant Governor Dummer announced a cessation of hostilities on 31 July 1725 following negotiations in March.:83 The terms of this preliminary agreement were negotiated by Dummer and Chiefs Loron and Wenemouet and applied only to the Penobscots at first. They were allowed to retain Jesuit priests, but the two parties were in disagreement concerning land titles and British sovereignty over the Wabanakis. The written agreement was translated into Abenaki by French Jesuit Etienne Lauverjat; Chief Loron immediately repudiated it, specifically rejecting claims of British sovereignty over him. Despite his disagreement, Loron pursued peace, sending wampum belts to other tribal leaders, although his envoys were unsuccessful in reaching Gray Lock, who continued his raiding expeditions. Peace treaties were signed in Maine on 15 December 1725 and in Nova Scotia on 15 June 1726, involving a large number of tribal chiefs. The peace was reconfirmed by all except Gray Lock at a major gathering at Falmouth in the summer of 1727; other tribal envoys claimed that they were not able to locate him. Gray Lock's activity came to an end in 1727, after which time he disappears from English records.
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At what event was Gray Lock discovered to be missing?
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Detailed Instructions: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
See one example below:
Problem: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Problem: A physical change in matter is a change in one or more of matters physical properties. Glass breaking is just one example of a physical change. Some other examples are shown in Figure 3.16 and in the video below. In each example, matter may look different after the change occurs, but its still the same substance with the same chemical properties. For example, smaller pieces of wood have the ability to burn just as larger logs do. MEDIA Click image to the left or use the URL below. URL: Because the type of matter remains the same with physical changes, the changes are often easy to undo. For example, braided hair can be unbraided again. Melted chocolate can be put in a fridge to re-harden. Dissolving salt in water is also a physical change. How do you think you could undo it? Did you ever make a "volcano," like the one in Figure 3.17, using baking soda and vinegar? What happens when the two substances combine? They produce an eruption of foamy bubbles. This happens because of a chemical change. A chemical change occurs when matter changes chemically into an entirely different substance with different chemical properties. When vinegar and baking soda combine, they form carbon dioxide, a gas that causes the bubbles. Its the same gas that gives soft drinks their fizz. Not all chemical changes are as dramatic as this "volcano." Some are slower and less obvious. Figure 3.18 and the video below show other examples of chemical changes. MEDIA Click image to the left or use the URL below. URL: How can you tell whether a chemical change has occurred? Often, there are clues. Several are demonstrated in Figures 3.17 and 3.18 and in the video below. MEDIA Click image to the left or use the URL below. URL: To decide whether a chemical change has occurred, look for these signs: Gas bubbles are released. (Example: Baking soda and vinegar mix and produce bubbles.) Something changes color. (Example: Leaves turn from green to other colors.) An odor is produced. (Example: Logs burn and smell smoky.) A solid comes out of a solution. (Example: Eggs cook and a white solid comes out of the clear liquid part of the egg.) Because chemical changes produce new substances, they often cannot be undone. For example, you cant change a fried egg back to a raw egg. Some chemical changes can be reversed, but only by other chemical changes. For example, to undo the tarnish on copper pennies, you can place them in vinegar. The acid in the vinegar reacts with the tarnish. This is a chemical change that makes the pennies bright and shiny again. You can try this yourself at home to see how well it works. If you build a campfire, like the one in Figure 3.19, you start with a large stack of sticks and logs. As the fire burns, the stack slowly shrinks. By the end of the evening, all thats left is a small pile of ashes. What happened to the matter that you started with? Was it destroyed by the flames? It may seem that way, but in fact, the same amount of matter still exists. The wood changed not only to ashes but also to carbon dioxide, water vapor, and other gases. The gases floated off into the air, leaving behind just the ashes. Assume you had measured the mass of the wood before you burned it. Assume you had also trapped the gases released by the burning wood and measured their mass and the mass of the ashes. What would you find? The ashes and gases combined have the same mass as the wood you started with. This example illustrates the law of conservation of mass. The law states that matter cannot be created or destroyed. Even when matter goes through physical or chemical changes, the total mass of matter always remains the same. (In the chapter Nuclear Chemistry, you will learn about nuclear reactions, in which mass is converted into energy. But other than that, the law of conservation of mass holds
Solution:
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After a physical change, matter may
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task470_mrqa_question_generation
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example solution: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Problem: Despite the Portuguese proclaiming themselves as hostile to the Spanish crown, the VOC nevertheless took the opportunity to prise away the string of coastal fortresses that comprised the Portuguese Empire: Malacca finally succumbed in 1641. Important battles also took place in the South China sea, initially with combined fleets of Dutch and English vessels, and subsequently exclusively Dutch ships assaulting Macau. Dutch attempts to capture Macau, to force China to replace the Portuguese or to settle the Pescadores failed, in part because of the long-standing diplomacy between the Portuguese and the Ming, but the Dutch were ultimately successful in acquiring the monopoly of trade with Japan. while the Dutch were unable in four attempts to capture Macau from where Portugal monopolised the lucrative China-Japan trade. The Dutch established a colony at Tayouan in 1624, present-day Anping in the south of Taiwan, known to the Portuguese as Formosa and in 1642 the Dutch took northern Formosa from the Spanish by force. The Dutch intervened in the Sinhalese-Portuguese War on Ceylon from 1638 onwards, initially as allies of the Kingdom of Kandy against Portugal. The Dutch conquered Batticaloa in 1639 and Galle in 1640 before the alliance broke down. After a period of triangular warfare between the Dutch, Portuguese and Kandyans, the alliance was remade in 1649. After exploiting and then double-crossing their Kandyan allies, the Dutch were able to capture Colombo in 1656 and drove the last Portuguese from Ceylon in 1658. Sporadic warfare with Kandy continued for over a century.
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Solution: Which European power were the Dutch attempting to take territory from before launching their assault on Spanish territory?
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Teacher: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Teacher: Now, understand the problem? If you are still confused, see the following example:
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Reason: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this instance: With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.
Student:
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What does mTOR stands for?
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Part 1. Definition
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Part 2. Example
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Answer: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Part 3. Exercise
Alison Gopnik (born June 16, 1955) is an American professor of psychology and affiliate professor of philosophy at the University of California, Berkeley.
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What is Alison Gopnik's place of employment?
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Teacher: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Teacher: Now, understand the problem? If you are still confused, see the following example:
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Reason: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this instance: De Quervain's disease has different clinical features. Different tests have been described in the past, the most popular test being the Eichhoff's test, often wrongly named as the Finkelstein's test. Over the years, a misinterpretation has occurred between these two tests, the latter being confused with the first. To compare the Eichhoff's test with a new test, the wrist hyperflexion and abduction of the thumb test, we set up a prospective study over a period of three years for a cohort of 100 patients (88 women, 12 men) presenting spontaneous pain over the radial side of the styloid of the radius (de Quervain tendinopathy). The purpose of the study was to compare the accuracy of the Eichhoff's test and wrist hyperflexion and abduction of the thumb test to diagnose correctly de Quervain's disease by comparing clinical findings using those tests with the results on ultrasound. The wrist hyperflexion and abduction of the thumb test revealed greater sensitivity (0.99) and an improved specificity (0.29) together with a slightly better positive predictive value (0.95) and an improved negative predictive value (0.67). Moreover, the study showed us that the wrist hyperflexion and abduction of the thumb test is very valuable in diagnosing dynamic instability after successful decompression of the first extensor compartment. Our results support that the wrist hyperflexion and abduction of the thumb test is a more precise tool for the diagnosis of de Quervain's disease than the Eichhoff's test and thus could be adopted to guide clinical diagnosis in the early stages of de Quervain's tendinopathy.
Student:
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Which disease is diagnosed using the Finkelstein's test?
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Detailed Instructions: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
See one example below:
Problem: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Problem: The Swc4p protein, encoded by an essential gene, is shared by two chromatin-remodeling complexes in Saccharomyces cerevisiae cells: NuA4 (nucleosome acetyltransferase of H4) and SWR1. The SWR1 complex catalyzes ATP-dependent exchange of the nucleosomal histone H2A for H2AZ (Htz1p). The activity of NuA4 is responsible mainly for the acetylation of the H4 histone but also for the acetylation of H2A and H2AZ. In this work we investigated the role of the Swc4p protein. Using random mutagenesis we isolated a collection of swc4 mutants and showed that the essential function of Swc4p resides in its N-terminal part, within the first 269 amino acids of the 476-amino acid-long protein. We also demonstrated that Swc4p is able to accommodate numerous mutations without losing its functionality under standard growth conditions. However, when swc4 mutants were exposed to methyl methanesulfonate (MMS), hydroxyurea or benomyl, severe growth deficiencies appeared, pointing to an involvement of Swc4p in many chromatin-based processes. The mutants' phenotypes did not result from an impairment of histone acetylation, as in the mutant which bears the shortest isolated variant of truncated Swc4p, the level of overall H4 acetylation was unchanged.
Solution:
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Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
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You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Why? The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
New input: After a tough win over the Texans, the Steelers stayed home for a game against the Colts. In the first quarter, the Colts scored first as Adam Vinatieri nailed a 31-yard field goal for a 3-0 lead. However, the Steelers took the lead later on in the quarter when Ben Roethlisberger found Markus Wheaton on an 18-yard TD pass for a 7-3 game. In the 2nd quarter, the Steelers would score again increasing their lead as Roethlisberger found Martavis Bryant on a 5-yard TD pass for a 14-3 game. This was followed by William Gay picking off Andrew Luck and returning it 33 yards for a TD as they increased their lead to 21-3. The Colts however responded as Andrew Luck threw a 21-yard TD pass to Dwayne Allen for a 21-10 game. However, the Steelers pulled away as Roethlisberger would find Antonio Brown on 2 consecutive TD passes: from 8 and 47 yards out to increase their lead at first from 28-10 to 35-10. The Colts responded with 10 straight points first being Luck who found T. Y. Hilton on a 28-yard TD Pass for a 35-17 game followed by Vinatieri kicking a 23-yard field goal before halftime to make the score 35-20. The Steelers went back to work in the 3rd quarter as Roethlisberger and Bryant hooked up again on a 2-yard TD pass to increase their lead making the score 42-20. The Colts however were able to come within 8 later on when Ahmad Bradshaw ran for a 12-yard TD followed by Luck finding Donte Moncrief on a 31-yard TD pass to make the score 42-27 and then 42-34. In the 4th quarter, it was all Steelers when a penalty was enforced on Luck in the end zone for a safety making the score 44-34. The Steelers were able to seal the game later on when Roethlisberger found Heath Miller on an 11-yard TD pass for a final score of 51-34. Roethlisberger set franchise records with 522 yards passing and six touchdowns while picking up his 100th victory in his 150th start. Roethlisberger's yardage total was the fourth highest in NFL history. He became the first player in NFL history to go over 500 yards passing twice as the Steelers won consecutive games for the first time this season.
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What quarter did the longest field goal kick of the game happen in?
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
[EX Q]: One Girl's Confession is a 1953 low-budget film noir released by Columbia Pictures.
[EX A]: What company released One Girl's Confession?
[EX Q]: The motion of an object can be represented by a position-time graph like Graph 1 in the Figure 1.1. In this type of graph, the y-axis represents position relative to the starting point, and the x-axis represents time. A position-time graph shows how far an object has traveled from its starting position at any given time since it started moving. Q: In the Figure 1.1, what distance has the object traveled from the starting point by the time 5 seconds have elapsed? A: The object has traveled a distance of 50 meters. In a position-time graph, the velocity of the moving object is represented by the slope, or steepness, of the graph line. If the graph line is horizontal, like the line after time = 5 seconds in Graph 2 in the Figure 1.2, then the slope is zero and so is the velocity. The position of the object is not changing. The steeper the line is, the greater the slope of the line is and the faster the objects motion is changing. Its easy to calculate the average velocity of a moving object from a position-time graph. Average velocity equals the change in position (represented by d) divided by the corresponding change in time (represented by t): velocity = d t For example, in Graph 2 in the Figure 1.2, the average velocity between 0 seconds and 5 seconds is: d t 25 m 0 m = 5 s0 s 25 m = 5s = 5 m/s velocity =
[EX A]: the slope of a position-time graph can be used to find the moving objects
[EX Q]: One Shell Square is a 51-story, 697-foot (212 m) skyscraper designed in the International style by Skidmore, Owings and Merrill, located at 701 Poydras Street in the Central Business District of New Orleans, Louisiana.
[EX A]:
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The designer for One Shell Square was?
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TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Legislative Studies Quarterly is a quarterly peer-reviewed academic journal published by Wiley-Blackwell and is the official journal of the Legislative Studies Section of the American Political Science Association.
SOLUTION: The publisher that published Legislative Studies Quarterly is what?
PROBLEM: Khin Sok, (Khmer: , born in 1942, Kandal Province, late French colonial Cambodia, died on 10. October 2011 in Paris) was a Cambodian historian, linguist, literature and arts scholar.
SOLUTION: What is the city of birth of Khin Sok?
PROBLEM: 9767 Midsomer Norton (1992 EB1) is an outer main-belt asteroid discovered on March 10, 1992 by Duncan Steel at Siding Spring.
SOLUTION:
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Who made the discovery of 9767 Midsomer Norton?
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TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: This Is Jackie DeShannon is an LP album by Jackie DeShannon, released by Imperial Records under catalog number LP-9286 as a monophonic recording in 1965, and later in stereo under catalog number LP-12286 the same year.
SOLUTION: What label was responsible for This Is Jackie DeShannon?
PROBLEM: Modeled after US hot website.com, group buying websites are now popular in China. These websites use the power of group buying to get competitive discounts for a daily deal on some best stuff to do, see, eat and buy in the cities across China. Discounts are available within just one click. Zhao lei, a software engineer in Beijing, loves the one-hour lunch break at noon,as it is the best time for him to check "today's special" at his favorite group buying websites . Sometimes he searches for great deals at directory sites devoted to the new shopping space. Zhao spends around 800 yuan($117.65) on group buying every month, mostly to buy food coupons for eating at some nice restaurants and occasionally to find something fun to do. " I love group buying. In addition to the competitive discounts it offers, it helps me get something fun, exciting and new, and such surprises give me a reason to try something new," he said. When he finds a really good bargain, he will send the link to friends or colleagues through MSN,QQ, or e-mail, or share the information at some social networking websites. In doing so, he often gets a certain cut off the price. At some sites, buyers are invited to leave notes about what they want to buy and the website will consider it if similar applications reach a certain number. That is how Zuo got her digital camera after waiting for two months. "It is cool. I want to buy a new digitgal camera for my trip to Switzerland this winter, but I never expected such cheap prices!" Zuo said.
SOLUTION: What is the passage mainly about?
PROBLEM: Recently mutations in the gene ZFHX1B (SIP1) were shown in patients with "syndromic Hirschsprung disease" with mental retardation (MR) and multiple congenital anomalies (MCA), but it was unclear if Hirschsprung disease is an obligate symptom of these mutations and if the distinct facial phenotype delineated by Mowat et al. [1998: J Med Genet 35: 617-623] is specific for ZFHX1B mutations. In order to address these open questions we analyzed the ZFHX1B gene in five patients, three of whom had "syndromic Hirschsprung disease" two with and one without the facial phenotype described by Mowat et al. [1998], and two of whom had the distinct facial gestalt without Hirschsprung disease. Analyses of microsatellite markers and newly identified SNPs, and/or FISH with BACs from the ZFHX1B region excluded large deletions in all five patients. Direct sequencing demonstrated truncating ZFHX1B mutations in all four patients with the characteristic facial phenotype, but not in the patient with syndromic Hirschsprung disease without the distinct facial appearance. We demonstrate that there is a specific clinical entity with a recognizable facial gestalt, mental retardation and variable MCAs which we propose be called the "Mowat-Wilson syndrome."
SOLUTION:
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Which gene is responsible for the development of the Mowat-Wilson syndrome?
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task470_mrqa_question_generation
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example input: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example output: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Q: Riparian Plaza was designed by Harry Seidler (architect) and Robert Bird Group (structural engineer).
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By which person Riparian Plaza has been designed?
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task470_mrqa_question_generation
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TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Mega Man Star Force 2, known in Japan as Shooting Star Rockman 2 (2 Ryusei no Rokkuman Tsu), is a video game developed by Capcom for the Nintendo DS handheld game console.
SOLUTION: Who worked on Mega Man Star Force 2?
PROBLEM: The Kaiser Shipyards were seven major shipbuilding yards located on the U.S. west coast during World War II. Kaiser ranked 20th among United States corporations in the value of wartime production contracts.
SOLUTION: Which industry is Kaiser Shipyards associated with?
PROBLEM: Miklos Ajtai (born 2 July 1946) is a computer scientist at the IBM Almaden Research Center, USA.
SOLUTION:
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What is Miklós Ajtai's place of employment?
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task470_mrqa_question_generation
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instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Presently the Appalachian elktoe is considered critically endangered, and it is unknown if they are still in fact actively reproducing.
answer:
What is the status of Appalachian elktoe?
question:
The tradition of birthday parties started in Europe a long time ago. It was feared that evil spirits were particularly attracted to people on their birthdays. To protect them from harm, friends and family members would come to stay with the birthday person and bring good thoughts and wishes. Giving gifts brought even more good cheer to keep away from the evil spirits. This is how birthday parties began. The following are some countries' birthday traditions: Canada---Putting butter on the nose. In Atlantic Canada, the birthday child's nose is put butter on for good luck. China---Noodles for lunch. The birthday child pays respect to his / her parents and receives a gift of money. Friends and relatives are invited to lunch and noodles are served to wish the birthday child a long life. England---Money cakes. Certain symbolic objects are mixed into the birthday cake as it is being prepared. If your piece of cake has a coin in it, you will be rich. Ireland---Birthday bump . The birthday child is lifted upside down and " bumped" on the floor for good luck. Italy---Pulling ears. The child's ears are pulled as many times as how old he / she is turning. Japan---New clothes. The birthday child wears new clothes to mark the occasion. New Zealand---Birthday claps. After the candles are hit, the happy birthday song is sung loudly and often out of tune and then the birthday person receives a clap for each year he / she has been alive and then one for good luck. The United States---Cake, candles and the birthday song. A cake is made, and candles are put on top based on how old the person is.
answer:
According to the passage, in which country can the birthday children probably receive a gift of money?
question:
Convenient location 5 minutes from Washington ,D.C. and one block to Crystal City METRO ,Crystal City Underground. Alexandria. Free Parking, free Deluxe Continental Breakfast and complimentary Hotel Shuttle Service to Ronald Reagan Washington National Airport. 14000 Jefferson Davis Hwy(endurance on S. Eads St.) Phone (703) 979-3722 DAYS INN ARLINGTON Days Inn Arlington is located two miles from the Pentagon ,Lincoln Memorial .There is a restaurant which serves American style food ,plus two meeting rooms and an outdoor pool. Complimentary shuttle service runs to the Rosslyn Metro Station. Complimentary parking is available on the property .An experienced staff welcomes our guests. Phone(703)525-0300 THE HIGHLANDER MOTOR INN Comfortable rooms at moderate rates . Convenient location only minutes away from Washington area attraction. Near VA Square METRO Station and Ballston Commons Shopping Mall. Free continental breakfast ,free parking. Phone(703)524-4300 HYATT REGENCY CRYSTAL CITY Conveniently located next to Washington National Airport and two miles from Washington D.C. Complimentary Shuttle to and from National Airport ,metro ,local restaurants and shopping .Experience a view to remember at out rooftop restaurants "Chesapeake Grill." Call for Reservations. Phone(073)418-12341
answer:
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Which hotel is close to airports?
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task470_mrqa_question_generation
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
[Q]: Carbon is one of the most common elements found in living organisms. Chains of carbon molecules form the backbones of many organic molecules, such as carbohydrates, proteins, and lipids. Carbon is constantly cycling between living organisms and the atmosphere ( Figure 1.1). The cycling of carbon occurs through the carbon cycle. Living organisms cannot make their own carbon, so how is carbon incorporated into living organisms? In the atmosphere, carbon is in the form of carbon dioxide gas (CO2 ). Recall that plants and other producers capture the carbon dioxide and convert it to glucose (C6 H12 O6 ) through the process of photosynthesis. Then as animals eat plants or other animals, they gain the carbon from those organisms. The chemical equation of photosynthesis is 6CO2 + 6H2 O C6 H12 O6 + 6O2 . How does this carbon in living things end up back in the atmosphere? Remember that we breathe out carbon dioxide. This carbon dioxide is generated through the process of cellular respiration, which has the reverse chemical reaction as photosynthesis. That means when our cells burn food (glucose) for energy, carbon dioxide is released. We, like all animals, exhale this carbon dioxide and return it back to the atmosphere. Also, carbon is released to the atmosphere as an organism dies and decomposes. Cellular respiration and photosynthesis can be described as a cycle, as one uses carbon dioxide (and water) and makes oxygen (and glucose), and the other uses oxygen (and glucose) and makes carbon dioxide (and water). The carbon cycle. The cycling of car- bon dioxide in photosynthesis and cellular respiration are main components of the carbon cycle. Carbon is also returned to the atmosphere by the burning of organic matter (combustion) and fossil fuels and decomposition of organic matter. Millions of years ago, there were so many dead plants and animals that they could not completely decompose before they were buried. They were covered over by soil or sand, tar or ice. These dead plants and animals are organic matter made out of cells full of carbon-containing organic compounds (carbohydrates, lipids, proteins and nucleic acids). What happened to all this carbon? When organic matter is under pressure for millions of years, it forms fossil fuels. Fossil fuels are coal, oil, and natural gas. When humans dig up and use fossil fuels, we have an impact on the carbon cycle ( Figure 1.2). This carbon is not recycled until it is used by humans. The burning of fossil fuels releases more carbon dioxide into the atmosphere than is used by photosynthesis. So, there is more carbon dioxide entering the atmosphere than is coming out of it. Carbon dioxide is known as a greenhouse gas, since it lets in light energy but does not let heat escape, much like the panes of a greenhouse. The increase of greenhouse gasses in the atmosphere is contributing to a global rise in Earths temperature, known as global warming or global climate change.
[A]: when organisms die, what process returns their carbon back into the atmosphere?
[Q]: We're always looking for well-written reviews of books, music, movies, television shows, websites, video games and other products. When writing a review, concentrate on exactly what you liked or didn't like. Give examples of strengths and weaknesses, be descriptive and provide background information on an author, director, actor or musician, if possible. Find professional reviews in magazines or newspapers and see how reviewers deal with their topic, but be sure to express your own voice in your review. Grammar Hint for Reviews: When describing a book, movie, album or anything else, use the present tense. Book Reviews Discuss an author's technique, strengths and weaknesses instead of focusing on the plot. Does the story flow? Is there a strong sense of character and place? Did you stay up until dawn to finish it? Is it good reading for teenagers? What influence did it have on you and why? If you've read other books by the same author, discuss how this book compares. Movie Reviews Think of the major Oscar categories and consider the performances, music, lighting and setting, etc. Do these work together? Did some hold up while others didn't? If the movie is based on a book, discuss whether one is better than the other and why. If the movie is a remake, compare the film to its original. Remember that a well-written movie review should discuss strengths and weaknesses. Some readers may not have seen a movie yet, so don't give away an exciting scene or the ending! College Reviews Begin by providing an overview of the college, including location, size and a description of the campus and/or dorm life. Think about all aspects of your college visit. What academic, athletic and after-class programs are available? What are the students like? What makes the college different from others? Every school has strengths and weaknesses. Be objective. Consider what the school has to offer and who might enjoy or benefit the most from attending there.
[A]: Which aspects should be included in all three reviews?
[Q]: In 2009, 78.5% of Dallas (city) commuters drive to work alone. The 2009 modal share for Dallas (city) commuters are 10.7% for carpooling, 3.9% for transit, 1.9% for walking, and .1% for cycling. In 2015, the American Community Survey estimated modal shares for Dallas (city) commuters of 75.4% for driving alone, 12.8% for carpooling, 3.5% for riding transit, 1.9% for walking, and .2% for cycling. The city of Dallas has a higher than average percentage of households without a car. In 2015, 10.2 percent of Dallas households lacked a car, and decreased to 9.1 percent in 2016. The national average was 8.7 percent in 2016. Dallas averaged 1.59 cars per household in 2016, compared to a national average of 1.8.
[A]:
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Which group of commuters in 2009 was the largest in Dallas, carpooling or transit?
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example input: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example output: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Q: Epidemiology of Clostridium difficile is characterized by worldwide increase of C. difficile infections (CDI) and the emergence of new epidemic outbreak strains with the capacity for global spreading. Long-term local surveillance at the University of Saarland Medical Center between 2000 and 2013 shows that the incidence rate of laboratory-confirmed CDI was influenced by local epidemiology as well as by testing strategies. Since 2008, molecular typing of C. difficile was regularly performed for symptomatic hospitalized patients by surface-layer protein A sequence typing (slpAST), which is an established highly standardized technique for genotyping of C. difficile. The results were assigned to known ribotypes for better comparison to international data. It could be demonstrated that distribution of genotypes was different between age groups. Older patients were predominantly infected with ribotype 001 and 027, whereas ribotype 027 was not detected in the pediatric population. Molecular typing of German isolates sent to the advisory laboratory between 2011 and 2013 revealed that ribotype 027 is present with high percentages in most German regions except for the very North. In conclusion, optimized testing of all hospitalized patients with diarrhea should be generally implemented to avoid under-diagnosis of C. difficile infection. Ribotype 027 is highly prevalent in Germany, but its infections are restricted to older patients, while absent in children. Molecular typing of suspected hospital outbreaks and of patients with severe or recurrent disease may help to better understand virulence and epidemic spreading of C. difficile.
A:
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Which main ribotype of Clostridium difficile is responsible of the recent outbreak?
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Ex Input:
There is plenty for kids and teens to do in the Syracuse area during the summer, including some great educational opportunities. Here are the top four. Rosamond Gifford Zoo Camp The zoo offers separate camps for kids. The camps for kindergarteners run from 9 am to 12:30 pm, and cost $115 for zoo members and $135 for non-members. Kids entering 7thand 8thgrades will have half a day from 1 pm to 4:30 pm. The cost is $149 for members and $160 for non-members. All camps feature numerous educational activities and animal encounters. The camps run from August 14 to August 19. Registration starts from July 10 for members and July 15 for non-members. Active Learning Services at Christian Brothers Academy From August 1 to August 5, Christian Brothers Academy will host Active Learning Services from USA Chess. Topics of learning will include Chess Camp (age 5-15), and Video Game Creation Program (age 8-15). Chess Camp promises improved chess skills through chess instructors utilizing demo boards and historic games. Half day sessions will cost $280 for the Computer Camps. A full day of Chess costs $400, and a half day of Chess followed by a half day of Computer Camps cost $430. Syracuse University Summer College From July 5thto August 12th, Syracuse University will host pre-college programs for high school students. The Summer College will offer a wide variety of programs including architecture, engineering and computer science, public communications, and eco-fashion. The programs are taught by the teachers of Syracuse University and include hands-on activities. The costs range from $2325 to $7642. The Sheldon Institute at SUNY Oswego The State University of New York will hold two-week educational enrichment programs for students entering grades2-4 from July 25 to August 5. Children will have a set program featuring art, science, technology, cultural appreciation and writing. Tuition for the programs is only $320 and a downloadable application is available.
Ex Output:
Where can children attend the largest number of programs with low cost?
Ex Input:
One Shell Square is a 51-story, 697-foot (212 m) skyscraper designed in the International style by Skidmore, Owings and Merrill, located at 701 Poydras Street in the Central Business District of New Orleans, Louisiana.
Ex Output:
The designer for One Shell Square was?
Ex Input:
Chronic myeloid leukemia (CML) is a progressive and often fatal myeloproliferative neoplasm. The hallmark of CML is an acquired chromosomal translocation known as the Philadelphia chromosome (Ph), which results in the synthesis of the breakpoint cluster region-Abelson murine leukemia (BCR-ABL) fusion oncoprotein, a constitutively active tyrosine kinase. The introduction of imatinib, a tyrosine kinase inhibitor (TKI) that is specific for BCR-ABL, was a major breakthrough in CML therapy. Although most patients respond to first-line imatinib therapy, some experience loss of response (resistance) or require treatment discontinuation because of toxicity (intolerance). For patients with CML, failure on standard-dose imatinib therapy (400 mg daily), imatinib dose escalation (600-800 mg daily) is a second-line option. However, high-dose imatinib is not an appropriate approach for patients who experience drug toxicity, and there remain questions over the durability of responses achieved with this strategy. Alternative second-line options include the TKIs dasatinib and nilotinib. A substantial amount of long-term data for these agents is available. Although both are potent and specific BCR-ABL TKIs, dasatinib and nilotinib exhibit unique pharmacologic profiles and response patterns relative to different patient characteristics, such as disease stage and BCR-ABL mutation status. To optimize therapeutic benefit, clinicians should select treatment based on each patient's historic response, adverse-event tolerance, and risk factors.
Ex Output:
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What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
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task470_mrqa_question_generation
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fs_opt
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Detailed Instructions: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
See one example below:
Problem: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Problem: How well soil forms and what type of soil forms depends on several different factors, which are described below. Scientists know that climate is the most important factor determining soil type because, given enough time, different rock types in a given climate will produce a similar soil (Figure 1.1). Even the same rock type in different climates will not produce the same type of soil. This is true because most rocks on Earth are made of the same eight elements and when the rock breaks down to become soil, those elements dominate. The same factors that lead to increased weathering also lead to greater soil formation. More rain equals more chemical reactions to weather minerals and rocks. Those reactions are most efficient in the top layers of the soil, where the water is fresh and has not yet reacted with other materials. Increased rainfall increases the amount of rock that is dissolved as well as the amount of material that is carried away by moving water. As materials are carried away, new surfaces are exposed, which also increases the rate of weathering. Climate is the most important factor in determining the type of soil that will form in a particular area. Increased temperature increases the rate of chemical reactions, which also increases soil formation. In warmer regions, plants and bacteria grow faster, which helps to weather material and produce soils. In tropical regions, where temperature and precipitation are consistently high, thick soils form. Arid regions have thin soils. Soil type also influences the type of vegetation that can grow in the region. We can identify climate types by the types of plants that grow there. The original rock is the source of the inorganic portion of the soil. The minerals that are present in the rock determine the composition of the material that is available to make soil. Soils may form in place or from material that has been moved. Residual soils form in place. The underlying rock breaks down to form the layers of soil that reside above it. Only about one-third of the soils in the United States are residual. Transported soils have been transported in from somewhere else. Sediments can be transported into an area by glaciers, wind, water, or gravity. Soils form from the loose particles that have been transported to a new location and deposited. The steeper the slope, the less likely material will be able to stay in place to form soil. Material on a steep slope is likely to go downhill. Materials will accumulate and soil will form where land areas are flat or gently undulating. Soils thicken as the amount of time available for weathering increases. The longer the amount of time that soil remains in a particular area, the greater the degree of alteration. The partial decay of plant material and animal remains produces the organic material and nutrients in soil. In soil, decomposing organisms breakdown the complex organic molecules of plant matter and animal remains to form simpler inorganic molecules that are soluble in water. Decomposing organisms also create organic acids that increase the rate of weathering and soil formation. Bacteria in the soil change atmospheric nitrogen into nitrates. The decayed remains of plant and animal life are called humus, which is an extremely important part of the soil. Humus coats the mineral grains. It binds them together into clumps that then hold the soil together, creating its structure. Humus increases the soils porosity and water-holding capacity and helps to buffer rapid changes in soil acidity. Humus also helps the soil to hold its nutrients, increasing its fertility. Fertile soils are rich in nitrogen, contain a high percentage of organic materials, and are usually black or dark brown in color. Soils that are nitrogen poor and low in organic material might be gray or yellow or even red in color. Fertile soils are more easily cultivated. Click image to the left or use the URL below. URL:
Solution:
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what type of climate produces the thickest soils?
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task470_mrqa_question_generation
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Part 1. Definition
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Part 2. Example
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Answer: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Part 3. Exercise
On March 26, 2008, Ludia (in connection with Ubisoft) launched The Price Is Right video game for PC. A version for the Wii and Nintendo DS platforms was released in September 2008, while a version for the iOS (Apple) was released in November 2008. The shows announcer, Fields, was the host of the computer version. The virtual set in the game resembles the set used in seasons 31 to 34. Ludia announced that all three platforms will receive a new version of the video game that was previewed at the Target Bullseye Lounge during the Electronic Entertainment Expo trade show on June 2-4, 2009. The Price Is Right 2010 Edition was released on September 22, 2009. In the fall of 2010, Ludia developed a multi-player version for Facebook. A third Ludia adaptation, The Price Is Right Decades, featuring set designs, pricing games and prizes taken from the 1970s through 2000s; was initially released for the Wii in October 2011, with an Xbox 360 and iOS release following in November and December. The Price Is Right 2010 Edition and The Price Is Right Decades have also been released as downloads within the PlayStation Store for the PlayStation 3 in May 2010 and April 2012, respectively. Irwin Toys released an electronic tabletop version in 2008 featuring Contestants Row, the Big Wheel, a physical Plinko board with chips, Showcases and seven pricing games. Jakks Pacific released a Plug It in & Play TV Games version of The Price Is Right in 2009, featuring Carey and Fields.
Answer:
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For which game did Xbox 360 receive a release before iOS?
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task470_mrqa_question_generation
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fs_opt
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Detailed Instructions: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
See one example below:
Problem: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Problem: Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as "The Dog Man" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to "investigate" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence
Solution:
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Who plays Samuel Stoat?
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
One example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution is here: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this: It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -"if 70% of water is used for agriculture then that's what we should target" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal.
Solution:
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What is the main idea of this passage?
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task470_mrqa_question_generation
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fs_opt
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You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Why? The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
New input: 1836 Komarov, provisional designation 1971 OT, is a main-belt asteroid discovered on 26 July 1971 by Nikolai Chernykh at the Crimean Astrophysical Observatory in Nauchnyj.
Solution:
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When was 1836 Komarov first discovered?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Sandford-on-Thames is a village and Parish Council beside the River Thames in Oxfordshire just south of Oxford.
answer:
Which is the body of water by Sandford-on-Thames?
question:
Finally, in 2001, SV Nord-Nordstern and SC Wedding-Rapide came together to form SV Nord Wedding 1893.
answer:
What year did SV Nord Wedding 1893 dissolve?
question:
Set in the Australian outback in the 1880s, the movie follows the series of events following the horrific rape and murder of the Hopkins family, allegedly committed by the infamous Burns brothers gang.The film opens in a brothel during a violent gunfight between the police and Charlie Burns' (Guy Pearce) gang, which ends with the deaths of all of the gang members except for Charlie and his younger brother Mikey. Captain Stanley (Ray Winstone) proposes to Charlie: he and Mikey can go free of the crimes they have committed if Charlie kills his older brother, Arthur (Danny Huston). Arthur is a mercurial psychopath who has become something of a legend and is so vicious that the Aboriginal tribes refer to him as "The Dog Man" and both the police and the Aboriginals refuse to go near his camp. Captain Stanley muses that perhaps the bounty hunters will kill Arthur in time and then states his intention to civilize the harsh Australian wilderness by bringing Arthur to justice and using Mikey as leverage. Charlie has nine days to find and kill Arthur, or else Mikey will be hanged from the gallows on Christmas Day.We discover why Captain Stanley is intent on taming Australia: he has been forced to move there with his delicate wife, Martha Stanley (Emily Watson), and apparently wants to make it an appropriate place for them to live. The Stanleys were also friends of the Hopkins family, leading Martha to have nightmares about her dead friends and the unborn child one of them is revealed to have carried. Word spreads of Stanley's deal with Charlie, primarily from Stanley's corrupt subordinate, Sergeant Lawrence (Robert Morgan), causing disgust among the townspeople.Shortly thereafter, Eden Fletcher (David Wenham), for whom Captain Stanley works, orders that Mikey be given one hundred lashes as punishment for the rape and murder of the Hopkins family. Stanley is aghast at this, not only because he believes that Mikey is innocent and the flogging will surely kill him, but because it would also break his deal with Charlie and thus put him and his wife in grave danger. Stanley sends Sergeant Lawrence away with tracker Jacko (David Gulpillil) and other men to "investigate" the reported slaying of Dan O'Riley by a group of Aborigines. Captain Stanley attempts to defend Mikey by gunpoint from the bloodthirsty townspeople, but is overruled once Martha arrives, insisting on revenge for her dead friends. Mikey is then brutally flogged, and horrifically wounded. The formerly excited townspeople slowly become disgusted and Martha faints at the ghastly display. After 40 lashes, Mikey has collapsed and the whip is soaked with blood. Captain Stanley grabs the whip and throws it at Fletcher, staining his face and suit with blood, who in turn fires Stanley.Meanwhile, Charlie rides a great distance in search of Arthur, drinking and apparently reflecting on what he will do. Along the way, he encounters an inebriated old man named Jellon Lamb (John Hurt). In the course of conversation, Charlie realizes that Lamb is a bounty hunter in pursuit of the Burns brothers and knocks him out. Later on, after sleeping on a rock bed, Charlie awakes and, before he can gather what's going on, is speared in the chest by a group of Aboriginal men standing over him. Seconds later a gunshot is heard and the head of the man who threw the spear explodes. Charlie then passes out.Charlie wakes up in the camp of his brother Arthur, which is located in caves among desolate mountains. Arthur's gang consists of Samuel Stoat (Tom Budge), who shot the Aboriginal man who had speared Charlie; a woman named Queenie (Leah Purcell) who tends to Charlie's wound; and a muscular Aboriginal man called Two-Bob (Tom E. Lewis). As he recovers from his wounds, Charlie has several opportunities to kill his brother, but does not. Not too far away from Arthur's camp, Sergeant Lawrence and his men have found and butchered a group of Aborigines. Arthur and Two-Bob find Lawrence's group while they sleep, ostensibly to get a horse for Charlie, and proceed to kill Jacko and Sergeant Lawrence. Before Arthur stomps Lawrence
answer:
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Who plays Samuel Stoat?
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task470_mrqa_question_generation
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fs_opt
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Teacher: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Teacher: Now, understand the problem? If you are still confused, see the following example:
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Reason: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this instance: The susceptibility to arbekacin (ABK) of methicillin-resistant Staphylococcus aureus (MRSA) was investigated to find out how it related to aac(6')/aph(2") gene. In 49 isolates of MRSA for which MIC of ABK ranged from 0.125 to 64 micrograms/ml, the MICs of ABK for 38 strains carrying aac(6')/aph(2") gene were widely distributed from 0.25 to 64, whereas those for 11 strains without that gene were all < or = 0.5 microgram/ml. Residual rate of ABK activity was higher than that of gentamicin after the reaction with each crude enzyme preparation extracted from 3 isolates of MRSA, carrying aac(6')/aph(2") and aad(4',4") genes. Furthermore, 97 strains of MRSA isolated at Kanagawa prefecture in Japan in 1999 were all sensitive to ABK, although 28 strains of them carried aac(6')/aph(2") gene. These results showed that ABK resistance was not necessarily related to carrying aac(6')/aph(2") gene in clinical isolates of MRSA.
Student:
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What is MRSA?
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task470_mrqa_question_generation
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fs_opt
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Given the task definition, example input & output, solve the new input case.
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Output: In what year did francis, duke of anjou leave the netherlands?
The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
New input case for you: From 2007 until 2012, the Pentagon's MRAP program deployed more than 12,000 MRAPs in the Iraq War and War in Afghanistan.
Output:
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What was the year that MRAP entered service?
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Let me give you an example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
The answer to this example can be: In what year did francis, duke of anjou leave the netherlands?
Here is why: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
OK. solve this:
As Tsushima had suffered greatly from its loss of trade with Korea as a result of the invasions, Yoshitoshi of the So family, then dominant in Tsushima, undertook the lead in the peace negotiations by Japan. He sent four peace missions to Joseon in 1599 to normalize relations. The first three were captured and sent directly to Beijing by Chinese troops, but the fourth one, in 1601, successfully obtained from the Joseon court the promise of a normalizing of relations upon the return of remaining Joseon captives. As Ming troops continued to be present in Korea following the withdrawal of Japanese forces, the major incentive for Joseon for the normalization of relations with Japan was the withdrawal of the Chinese soldiers from their territory. The Ming Chinese themselves were causing as much havoc as the Japanese had during the actual conflict, and their presence continued to strain Joseon's national economy and infrastructure. In response to the Joseon request, Yoshitoshi promptly released several Joseon prisoners and between 1603 and 1604 helped the Joseon envoys to repatriate a further 3,000 by organizing negotiations at Kyoto with Tokugawa Ieyasu, by then the Shogun of Japan. In the continuation of the diplomatic talks toward peaceful relations, Joseon in 1606 expanded its conditions and demanded that the Shogun write a formal letter requesting peace, and to extradite the Japanese soldiers who had defiled the Joseon Royal Tombs near Hanseong . Realizing that the Shogunate would never agree to such a request, Yoshitoshi sent a forged letter and a group of criminals instead; the great need to expel the Ming soldiers pushed Joseon into accepting and to send an emissary in 1608. The end result was a return of Joseon prisoners and the restoration of diplomatic and trade relations between the two countries.
Answer:
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Who sent four peace missions to Joseon in 1599?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example solution: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Problem: The Local Stigmatic is based on a stage play by Heathcote Williams.
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Solution: In which The Local Stigmatic a 1909 american silent drama film directed by?
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task470_mrqa_question_generation
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Q: Phoebe Campbell (c. 1847 -- 20 June 1872) was a Canadian woman who was hanged for the murder of her husband.
A: Which crime Phoebe Campbell is considered to have commited?
****
Q: Lewy bodies and coarse Lewy neurites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions are present in the axonal processes of neurons.
A: Which is the primary protein component of Lewy bodies?
****
Q: The Local Stigmatic is based on a stage play by Heathcote Williams.
A:
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In which The Local Stigmatic a 1909 american silent drama film directed by?
****
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task470_mrqa_question_generation
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TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Luka orevic (Cyrillic: a , born 9 July 1994) is a Montenegrin footballer who plays as a forward for Spanish club SD Ponferradina on loan from FC Zenit Saint Petersburg.
SOLUTION: The birth date of Luka Đorđević is what?
PROBLEM: "We don't necessarily believe that new advertising, which might make consumers feel better about the Coke brand or better about the ads themselves , will actually result in consumers consuming more of the product," Morgan Stanley's Bill Pecoriello wrote in a research note the days after the investor meeting . But Coke is optimistic it can regain its old magic, and is banking on a new slogan: "Welcome to the Coke side of life." BREAK THROUGH HIT? With PepsiCo about to surpass Coke as the beverage king on Wall Street--Pepsi's market capitalization has _ in recent years to $97.9 billion, putting it less than a billion dollars behind its rival--the heat is on Coke . It's set to launch a new marketing campaign in March, 2006. And having taken a quick look at Coke's investor presentation on Dec. 7 in New York, my sense is that Coke may be moving in the right direction . Given the continued shift by consumers away from soda--Coke's stronghold --and into alternative beverages like juice, tea, and water, Coke badly needs a breakthrough hit. And given that shift away from soda, some analyists wonder whether even the catchiest new ads will be enough to put the fizz back into Coke. SAME OLD, UPDATED? The new flavors of PowerAde sports drink will probably enable Coke to continue stealing market share from PepsiCo's Gatorade brand. And Coke is getting a little more creative with packaging, including new, aluminum bottles of Coke that will be sold in nightclubs, and an 8.4-ounce "100 calorie" version of its flagship Coke that will appeal to women who want fewer calories and will like the fact that the small can will fit in their purse. I doubt whether other new products will be successful, including a new coffee-flavored soda called Coke-Cola Black that I tried. Think carbonated coffee. But I'm not sure if the product, which Coke is pitching as an afternoon pick-me-up for the 35-and-over set, is going to pull people away from their afternoon Frappucino fix. And my opinion is that Vault, an orange-flavored energy drink, will have just as much trouble unseating Mountain Dew among teens as did Coke's last attempt, a product called Surge. If there is one concern I have about the fresh offerings Coke plans to launch this year, it appears that many of them are simply new brands, not new products.
SOLUTION: When the middle-aged people feel tired, what would they prefer to drink in order to continue their work?
PROBLEM: Ptolemy III Euergetes (Greek: , Ptolemaios Euergetes, reigned 246--222 BC) was the third king of the Ptolemaic dynasty in Egypt.
SOLUTION:
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What family lineage was Ptolemy III Euergetes part of?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
[EX Q]: If you wish to become a better reader, here are four important things to remember about reading _ : * Knowing why you are reading or what you are reading to find out will often help you to know whether to read rapidly or slowly. * Some things should be read slowly throughout. Examples are directions for making or doing something, arithmetic problems, science and history books, which are full of important information. You must read such things slowly to remember each important step and understand each important ideas. * Some things should be read rapidly throughout. Examples are simple stories meant for enjoyment, news letters from friends, pieces of news from local, or home-town, papers, telling what is happening to friends and neighbors. * In some of your reading, you must change your speed from fast to slow and slow to fast, as you go along. You will need to read certain pages rapidly and then slow down and do more careful reading when you come to important ideas which must be remembered.
[EX A]: Which should be read slowly according to the passage?
[EX Q]: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients.
[EX A]: Which gene is involved in CADASIL?
[EX Q]: HD 27245 is a variable red giant star in the northern constellation of Camelopardalis.
[EX A]:
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What constellation is HD 27245 in?
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Input: Consider Input: Coming off their last-second victory over the Bengals, the Broncos would play their Week 2 home opener against the Cleveland Browns. In the first quarter, Denver would trail early as Browns kicker Phil Dawson got a 22-yard field goal. Afterwards, the Broncos took the lead as quarterback Kyle Orton completed a 2-yard touchdown pass to tight end Tony Scheffler. Cleveland would creep close as Dawson made a 47-yard field goal, but Denver would answer as kicker Matt Prater got a 23-yard field goal in the second quarter and a 38-yard field goal in the third quarter. In the fourth, the Broncos pulled away as fullback Peyton Hillis got a 2-yard touchdown run and running back Correll Buckhalter got a 45-yard touchdown run.
Output: Which player kicked the second longest field goal?
Input: Consider Input: CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 different mutations in the NOTCH3 gene have been reported in CADASIL patients, of which 95% are missense point mutations. Many polymorphisms have also been identified in the NOTCH3 coding sequence, some of them leading to amino acid substitutions. The aim of the present study was to analyze the NOTCH3 gene in a large group of patients affected by leukoencephalopathy and to investigate the presence of genetic variants. The molecular analysis revealed several nucleotide alterations. In particular, we identified 20 different mutations, 22 polymorphisms, and 8 genetic variants of unknown pathological significance never reported previously. We hope that this NOTCH3 gene mutational analysis, performed in such a significant number of unrelated and related patients affected by leukoencephalopathy, will help in molecular screening for the NOTCH3 gene, thus contributing to enlargement of the NOTCH3 gene variation database.
Output: Which amino acid residue appears mutated in most of the cases reported with cadasil syndrome?
Input: Consider Input: The Seattle Seahawks kicked off their 2013 campaign with a hard-fought, ugly win over the Carolina Panthers, 12-7. This game marked Russell Wilson's first 300-yard passing game, and Cam Newton's worst career performance, posting 125 yards through the air, a career low. The first quarter ended equal for both teams, as both sides exchanged a couple of punts. Seattle took their third drive of the game in the second quarter, and drove into the red zone, capping it with a Steven Hauschka 27-yard field goal. Carolina responded immediately, and taking advantage of a couple of Seattle penalties, and some big runs by DeAngelo Williams, with Cam Newton hitting Steve Smith for a 3-yard TD. Seattle responded with a drive to around the Carolina 27 yard line, but Charles Godfrey sacked Russell Wilson and stripped the football, which Carolina recovered. So the first half ended 7-3, Carolina. The second half began with a defensive battle between both sides. Seattle then broke the deadlock with a Steven Hauschka 40-yard field goal, on a drive that lasted over 4 minutes, cutting the lead to 7-6. After forcing Carolina to punt midway through the fourth quarter, Seattle's offense produced its finest drive of the day. A couple of Russell Wilson passes, followed by a Robert Turbin 15-yard scamper, set up Seattle at the Panthers' 43 yard line. Russell Wilson overthrew receiver Stephen Williams on first down, but on second down and 10, by using exactly the same play, Wilson connected with second-year man Jermaine Kearse for a 43-yard score, with 10 minutes left to play. They failed the two-point conversion however, so Seattle had a 12-7 lead. Carolina responded by using DeAngelo Williams on some big runs. Inside the Seattle 35 yard line, Williams took off for a 24-yard scamper, and looked like he was going to score, however at the last possible moment, Earl Thomas forced Williams to fumble inside the 10 yard line.
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Output: Who threw for more yards, Wilson or Newton?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Ex Input:
Mercury is released into the atmosphere when coal is burned (Figure 1.1). But breathing the mercury is not harmful. In the atmosphere, the mercury forms small droplets that are deposited in water or sediments. Do you know why you are supposed to eat large predatory fish like tuna infrequently? It is because of the bioaccu- mulation of mercury in those species. Some pollutants remain in an organism throughout its life, a phenomenon called bioaccumulation. In this process, an organism accumulates the entire amount of a toxic compound that it consumes over its lifetime. Not all substances bioaccumulate. Can you name one that does not? Aspirin does not bioaccumulate; if it did, a person would quickly accumulate a toxic amount in her body. Compounds that bioaccumulate are usually stored in the organisms fat. In the sediments, bacteria convert the droplets to the hazardous compound methyl mercury. Bacteria and plankton store all of the mercury from all of the seawater they ingest (Figure 1.2). A small fish that eats bacteria and plankton accumulates all of the mercury from all of the tiny creatures it eats over its lifetime. A big fish accumulates all of the mercury from all of the small fish it eats over its lifetime. For a tuna at the top of the food chain, thats a lot of mercury. Historic increases of mercury in the atmo- sphere: blue is volcanic eruptions; brown, purple, and pink are human-caused. The red region shows the effect of industrial- ization on atmospheric mercury. So tuna pose a health hazard to anything that eats them because their bodies are so high in mercury. This is why the government recommends limits on the amount of tuna that people eat. Limiting intake of large predatory fish is especially important for children and pregnant women. If the mercury just stayed in a persons fat, it would not be harmful, but that fat is used when a woman is pregnant or nursing a baby. A person will also get the mercury into her system when she (or he) burns the fat while losing weight. Methyl mercury poisoning can cause nervous system or brain damage, especially in infants and children. Children may experience brain damage or developmental delays. The phrase mad as a hatter was common when Lewis Carroll wrote his Alice in Wonderland stories. It was based on symptoms suffered by hatters who were exposed to mercury and experienced mercury poisoning while using the metal to make hats (Figure 1.3). Like mercury, other metals and VOCS can bioaccumulate, causing harm to animals and people high on the food chain. Mercury, a potent neurotoxin, has been flowing into the San Francisco Bay since the Gold Rush Era. It has settled in the bays mud and made its way up the food chain, endangering wildlife and making many fish unsafe to eat. Now a multi-billion-dollar plan aims to clean it up. Click image to the left or use the URL below. URL:
Ex Output:
mercury poisoning can drive a person to be as mad as a hatter, which is based off of this novel.
Ex Input:
NASCAR Thunder 2002 is a racing simulator video game developed by EA Tiburon and published by EA Sports that came out for the Sony PlayStation, Sony PlayStation 2, and Xbox.
Ex Output:
Who worked on NASCAR Thunder 2002?
Ex Input:
The susceptibility to arbekacin (ABK) of methicillin-resistant Staphylococcus aureus (MRSA) was investigated to find out how it related to aac(6')/aph(2") gene. In 49 isolates of MRSA for which MIC of ABK ranged from 0.125 to 64 micrograms/ml, the MICs of ABK for 38 strains carrying aac(6')/aph(2") gene were widely distributed from 0.25 to 64, whereas those for 11 strains without that gene were all < or = 0.5 microgram/ml. Residual rate of ABK activity was higher than that of gentamicin after the reaction with each crude enzyme preparation extracted from 3 isolates of MRSA, carrying aac(6')/aph(2") and aad(4',4") genes. Furthermore, 97 strains of MRSA isolated at Kanagawa prefecture in Japan in 1999 were all sensitive to ABK, although 28 strains of them carried aac(6')/aph(2") gene. These results showed that ABK resistance was not necessarily related to carrying aac(6')/aph(2") gene in clinical isolates of MRSA.
Ex Output:
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What is MRSA?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example input: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example output: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Q: Individuals with Mowat-Wilson syndrome (MWS; OMIM#235730) have characteristic facial features, a variety of congenital anomalies such as Hirschsprung disease, and intellectual disabilities caused by mutation or deletion of ZEB2 gene. This deletion or cytogenetic abnormality has been reported primarily from Europe, Australia and the United States, but not in Korea. Here we report a patient with characteristic facial features of MWS, developmental delay and spasticity. High resolution microarray analysis revealed 0.9 Mb deletion of 2q22.3 involving two genes: ZEB2 and GTDC1. This case shows the important role of high resolution microarray in patients with unexplained psychomotor retardation and/or facial dysmorphism. Knowledge about the most striking clinical signs and implementation of effective molecular tests like microarray could significantly increase the detection rate of new cases of MWS in Korea. This is the first reported case of MWS in Korea.
A:
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Which gene is responsible for the development of the Mowat-Wilson syndrome?
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
One example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution is here: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this: Britons spend as much as nearly five hours a week keeping their homes clean, a survey found. Kitchens are cleaned most often, while doing the oven and windows are the least popular jobs. In total, they spend just over PS1 billion a year on products to keep the dirt at bay -- almost PS40 per household. Market analyst Mintel found a clear division of labour. While the average Briton spends 4 hours, 40 minutes cleaning their home each week, men spend just 3 hours, 53 minutes compared to 5 hours, 25 minutes for women. And while seven in ten women say they do most of the cleaning, this falls to four in ten for men. Confirming many parents' feelings, only one in five adult children and over living at their parents' home helps with cleaning chores, with children under 18 doing even less. Last year, the household cleaning market was worth PS1.06 billion, which equates to annual spending of PS39.89 per household. Those looking for the cleanest homes in the country should head to Scotland, where people spend an average of five fours, 6 minutes, which is closely followed by East and West Midlands at five hours, 1 minute. In comparison, the least number of hours spent in cleaning is spent in the southeast/East Anglia at four hours, 18 minutes. The southwest and Wales stand at four hours, 46 minutes, the northwest four hours, 44 minutes, and Yorkshire and the Humber four hours, 21 minutes. According to Richard Caines, Mintel's senior household care analyst, men still lag women in the household cleaning stakes and spend on average an hour and a half less time cleaning their home, suggesting an opportunity for a campaign to encourage more cleaning by men to helpredressthis imbalance. The number of households that need cleaning is continuing to grow, but pressure on time from increasingly busy lives limits the number of hours people are willing or able to spend cleaning their homes. This means the market will see an increasing focus on easy-to-use, but effective hard surface cleaners and cleaning equipment. Such products can help encourage more cleaning to be done in less time, but as well as focusing on more convenient products, cleaning brands can also inject an element of fun into campaigns through encouraging a more shared approach that involves the whole family. This will also help to address the gender imbalance and get older children to make more of a contribution to cleaning.
Solution:
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In which area do people spend the most time cleaning their home each week?
| 6
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NIv2
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task470_mrqa_question_generation
|
fs_opt
|
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Let me give you an example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
The answer to this example can be: In what year did francis, duke of anjou leave the netherlands?
Here is why: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
OK. solve this:
The Jets' seventh game was an interconference duel with the Packers. Punter Steve Weatherford made the game's most controversial decision in the first quarter, opting to attempt a fake punt and run for the first down on 4th and 18. Weatherford was stopped a yard short of the first down, giving the Packers ideal field position which eventually led to an early 3-0 Packers lead. "He does it on his own," Ryan said. "(The Packers) were caving that side down. This was something Steve did on his own. I don't think he realized we'd just been sacked. We told him before that it needed to be a manageable situation, not fourth-and-20 or whatever it was.". In a game where defense ruled, the Packers lead 3-0 at halftime. The Jets challenged a Brad Smith fumble, and lost due to his knee not being down before losing the ball. However, the Jets second challenge went to a jump ball, called an interception after Packers cornerback Tramon Williams ripped the ball out of Jerricho Cotchery's hands while they were both on the ground. The play was controversially upheld, despite the fact that the receiver appeared to be down by contact. With no challenges left, Mark Sanchez threw a ball to Dustin Keller that was ripped out of his hands and ruled an interception in the 4th quarter. The replay showed that Keller made the catch and was also down before losing possession, but with no challenges left the Jets were left with nothing. Green Bay took a 6-0 lead after the turnover. The Jets had two more chances to take the lead but had drives halted on 4th and longs. The Packers added on another field goal late to finalize a 9-0 win in the New Meadowlands Stadium. This marked the first time since 2006 the Jets were shut out.
Answer:
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Which team scored the least points?
| 8
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NIv2
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task470_mrqa_question_generation
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fs_opt
|
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example input: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example output: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Q: Infectious Mononucleosis (IM), a benign lymphoproliferative disease, is the best known clinical syndrome caused by Epstein-Barr Virus (EBV). It usually resolves over a period of weeks or months without sequelae but may occasionally be complicated by a wide variety of neurologic, hematologic, hepatic, respiratory, and psychological complications. In this report we describe a patient with acute hepatitis following EBV-IM in a previously healthy woman. A 26-year-old woman who presented with fever, generalized weakness, nausea, sore throat, yellowing of skin, and a generalized skin rash was admitted to our clinic. Tonsillar enlargement, pharyngeal erythema, palatal petechiae, lymphadenopathy, and jaundice were noted. Significant atypical lymphocytes ( > 10%) were seen on the peripheral blood smear. Liver function tests such as ALT: 303 U/L, AST: 172 U/L, ALP: 193 U/L and total bilirubin: 7.3 mg/dl were elevated. Serological tests for EBV infection were consistent with acute infection (EBV virus capsid antigen was reactive with IgM and IgG antibodies). The Monospot test was also positive. On the seventh day, liver function tests and bilirubin had risen to peak level and platelets were decreased. The patient was managed supportively and her critical condition improved and was finally stabilized. Although the prognosis for IM is very favorable, a variety of acute complications may occur.
A:
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Which virus can be diagnosed with the monospot test?
| 3
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Let me give you an example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
The answer to this example can be: In what year did francis, duke of anjou leave the netherlands?
Here is why: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
OK. solve this:
The Seattle Seahawks kicked off their 2013 campaign with a hard-fought, ugly win over the Carolina Panthers, 12-7. This game marked Russell Wilson's first 300-yard passing game, and Cam Newton's worst career performance, posting 125 yards through the air, a career low. The first quarter ended equal for both teams, as both sides exchanged a couple of punts. Seattle took their third drive of the game in the second quarter, and drove into the red zone, capping it with a Steven Hauschka 27-yard field goal. Carolina responded immediately, and taking advantage of a couple of Seattle penalties, and some big runs by DeAngelo Williams, with Cam Newton hitting Steve Smith for a 3-yard TD. Seattle responded with a drive to around the Carolina 27 yard line, but Charles Godfrey sacked Russell Wilson and stripped the football, which Carolina recovered. So the first half ended 7-3, Carolina. The second half began with a defensive battle between both sides. Seattle then broke the deadlock with a Steven Hauschka 40-yard field goal, on a drive that lasted over 4 minutes, cutting the lead to 7-6. After forcing Carolina to punt midway through the fourth quarter, Seattle's offense produced its finest drive of the day. A couple of Russell Wilson passes, followed by a Robert Turbin 15-yard scamper, set up Seattle at the Panthers' 43 yard line. Russell Wilson overthrew receiver Stephen Williams on first down, but on second down and 10, by using exactly the same play, Wilson connected with second-year man Jermaine Kearse for a 43-yard score, with 10 minutes left to play. They failed the two-point conversion however, so Seattle had a 12-7 lead. Carolina responded by using DeAngelo Williams on some big runs. Inside the Seattle 35 yard line, Williams took off for a 24-yard scamper, and looked like he was going to score, however at the last possible moment, Earl Thomas forced Williams to fumble inside the 10 yard line.
Answer:
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Who threw for more yards, Wilson or Newton?
| 8
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NIv2
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task470_mrqa_question_generation
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fs_opt
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TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: In 1997 the Kymi Province was merged with the Uusimaa Province and the southern parts of the Hame Province into the new Southern Finland Province.
SOLUTION: What was replaced Kymi Province?
PROBLEM: Rigel Pharmaceuticals Inc is developing fostamatinib, a prodrug of the spleen tyrosine kinase (Syk) inhibitor R-406, for the potential treatment of autoimmune diseases such as rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and B-cell lymphomas. Syk is a key mediator of Fc and B-cell receptor signaling in inflammatory cells, such as B-cells, mast cells, macrophages and neutrophils. Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. In a phase II clinical trial, fostamatinib treatment effectively improved American College of Rheumatology response rates in patients with RA. Preclinical studies and phase II trials also suggested the potential of using fostamatinib for the treatment of ITP and B-cell lymphomas, by increasing platelet counts and inducing response rates, respectively. Fostamatinib is orally bioavailable and was well tolerated in phase I and II trials, with the most common side effect being gastrointestinal symptoms. At the time of publication, phase II trials for fostamatinib were ongoing in patients with RA, ITP and B-cell lymphomas. The Syk inhibitor appears to be a promising therapeutic for immunological diseases, but further data are required to establish the efficacy and long-term safety of the drug in humans.
SOLUTION: Which enzyme is inhibited by a drug fostamatinib?
PROBLEM: The IUCN, however, ranks the Canada warbler as a species of least concern.
SOLUTION:
|
What is the status of Canada warbler?
| 8
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Q: Throughout 1476, supporters of Joanna from the nobility continued to submit to Isabella and Ferdinand, particularly those from the Pacheco-Giron lineage: Juan Tellez-Giron and his brother Rodrigo; Luis de Portocarrero; and, in September, the Marquis of Villena. In November 1476, Isabella's troops captured the castle of Toro. In the following months, they took control of the last bordering localities controlled by the Portuguese and dealt with their adversaries in Extremadura. In July 1477, Isabella arrived in Seville, the most populous city of Castile, with the objective of asserting her power over the nobility of Andalusia. In April 1476, Isabella and Ferdinand gave their first exculpation to the Marquis of Cadiz. He had been regaining power while his rival, the Duke of Medina Sidonia, initially the main Isabella supporter in Andalusia, had been falling into dishonour. Through skilful negotiations, the Queen managed to take control of the main strongholds of Seville occupied by the Marquis and the Duke and, instead of returning them to their legitimate owners, named others as their heads. She prohibited both nobles from entering the city of Seville, under the pretext that their simultaneous presence there would risk violent conflicts. In this way the Duke's political dominance over Seville disappeared, and the city passed into the control of the Crown. One of the few nobles that refused to submit to the monarchs was Marshall Fernan Arias de Saavedra. Isabella's troops laid siege to his fortress at Utrera, and conquered it by assault in March 1478. The defeated suffered harsh repression. The first son of the monarchs, John of Aragon and Castile, was born in Seville on June 30, 1478, which opened new possibilities for dynastic stability of the Isabellian side.
A: What event happened first, Isabella arriving in Seville or Isabella and Ferdinand giving their first exculpation to the Marquis of Cadiz?
****
Q: An 11-day embryonic Swiss Webster/NIH mouse cDNA library was screened with a partial murine selenoprotein P cDNA probe and a murine selenoprotein-P-type cDNA clone of 2075 bp length was obtained. The clone contained a 5'-leader sequence of 132 bp length, the selenoprotein P coding frame, and 803 base pairs in the 3' untranslated region. Alignment and RNA folding studies revealed the presence of two well conserved selenocysteine inserting motifs in the 3' flanking region. The deduced polypeptide sequence comprises 380 residues including ten selenocysteines. Identical amino acid residues in homologous positions are 86%, 71%, and 64% when compared to the previously reported selenoprotein P sequences of rat, man, and cattle, respectively. The comparatively low similarity between the selenoprotein P sequences reported so far leaves open the question whether they belong to the same molecular clade.
A: Which is the human selenoprotein that contains several Se-Cys residues?
****
Q: Interleukin-1 (IL-1) is a key orchestrator in inflammatory and several immune responses. IL-1 exerts its effects through interleukin-1 receptor type I (IL-1RI) and interleukin-1 receptor accessory protein (IL-1RAcP), which together form a heterotrimeric signaling-competent complex. Canakinumab and gevokizumab are highly specific IL-1 monoclonal antibodies. Canakinumab is known to neutralize IL-1 by competing for binding to IL-1R and therefore blocking signaling by the antigen:antibody complex. Gevokizumab is claimed to be a regulatory therapeutic antibody that modulates IL-1 bioactivity by reducing the affinity for its IL-1RI:IL-1RAcP signaling complex. How IL-1 signaling is affected by both canakinumab and gevokizumab was not yet experimentally determined. We have analyzed the crystal structures of canakinumab and gevokizumab antibody binding fragment (Fab) as well as of their binary complexes with IL-1. Furthermore, we characterized the epitopes on IL-1 employed by the antibodies by NMR epitope mapping studies. The direct comparison of NMR and X-ray data shows that the epitope defined by the crystal structure encompasses predominantly those residues whose NMR resonances are severely perturbed upon complex formation. The antigen:Fab co-structures confirm the previously identified key contact residues on IL-1 and provide insight into the mechanisms leading to their distinct modulation of IL-1 signaling. A significant steric overlap of the binding interfaces of IL-1R and canakinumab on IL-1 causes competitive inhibition of the association of IL-1 and its receptor. In contrast, gevokizumab occupies an allosteric site on IL-1 and complex formation results in a minor reduction of binding affinity to IL-1RI. This suggests two different mechanisms of IL-1 pathway attenuation.
A:
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Which molecule is targeted by the drug Gevokizumab?
****
| 4
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given the task definition, example input & output, solve the new input case.
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Output: In what year did francis, duke of anjou leave the netherlands?
The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
New input case for you: RNA editing by deamination of specific adenosine bases to inosines during pre-mRNA processing generates edited isoforms of proteins. Recoding RNA editing is more widespread in Drosophila than in vertebrates. Editing levels rise strongly at metamorphosis, and Adar(5G1) null mutant flies lack editing events in hundreds of CNS transcripts; mutant flies have reduced viability, severely defective locomotion and age-dependent neurodegeneration. On the other hand, overexpressing an adult dADAR isoform with high enzymatic activity ubiquitously during larval and pupal stages is lethal. Advantage was taken of this to screen for genetic modifiers; Adar overexpression lethality is rescued by reduced dosage of the Rdl (Resistant to dieldrin), gene encoding a subunit of inhibitory GABA receptors. Reduced dosage of the Gad1 gene encoding the GABA synthetase also rescues Adar overexpression lethality. Drosophila Adar(5G1) mutant phenotypes are ameliorated by feeding GABA modulators. We demonstrate that neuronal excitability is linked to dADAR expression levels in individual neurons; Adar-overexpressing larval motor neurons show reduced excitability whereas Adar(5G1) null mutant or targeted Adar knockdown motor neurons exhibit increased excitability. GABA inhibitory signalling is impaired in human epileptic and autistic conditions, and vertebrate ADARs may have a relevant evolutionarily conserved control over neuronal excitability.
Output:
|
Which is the major RNA editing enzyme in Drosophila melanogaster?
| 1
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
One example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution is here: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this: Turner's syndrome is defined as a congenital disease determining by quantitative and/or structural aberrations of one from two X chromosomes with frequent presence of mosaicism. Clinically it is characterized by growth and body proportion abnormalities, gonadal dysgenesis resulting in sexual infantilism, primary amenorrhoea, infertility, characteristic stigmata, anomalies of heart, renal and bones and the presence of some diseases like Hashimoto thyroiditis with hypothyroidism, diabetes mellitus type 2, osteoporosis, hypertension. Turner's syndrome occurs in 1:2000 to 1:2500 female livebirth. The most frequent X chromosome aberrations in patients with phenotype of Turner syndrome are as follows: X monosomy - 45,X; mosaicism (50-75%), including 45,X/46,XX (10-15%), 45,X/46,XY (2-6%), 45,X/46,X,i(Xq), 45,X/46,X,del(Xp), 45,X/46,XX/47,XXX; aberration of X structure: total or partial deletion of short arm of X chromosome (46,X,del(Xp)) isochromosom of long arm of X chromosome (46,X,(i(Xq)), ring chromosome (46, X,r(X)), marker chromosome (46,X+m). Searching of X chromosome and mapping and sequencing of genes located at this chromosome (such as SHOX, ODG2, VSPA, SOX 3) have made possible to look for linkage between phenotypes and adequate genes or regions of X chromosome. In this paper current data concerning correlation between phenotype and karyotype in patients with TS have been presented.
Solution:
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What chromosome is affected in Turner's syndrome?
| 6
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NIv2
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task470_mrqa_question_generation
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fs_opt
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You will be given a definition of a task first, then an example. Follow the example to solve a new instance of the task.
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution: In what year did francis, duke of anjou leave the netherlands?
Why? The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
New input: Selenocysteine (Sec), the 21st amino acid in protein, is encoded by UGA. The Sec insertion sequence (SECIS) element, which is the stem-loop structure present in 3' untranslated regions (UTRs) of eukaryotic selenoprotein-encoding genes, is essential for recognition of UGA as a codon for Sec rather than as a stop signal. We now report the identification of a new eukaryotic selenoprotein, designated selenoprotein M (SelM). The 3-kb human SelM-encoding gene has five exons and is located on chromosome 22 but has not been correctly identified by either Celera or the public Human Genome Project. We characterized human and mouse SelM cDNA sequences and expressed the selenoprotein in various mammalian cell lines. The 3" UTR of the human, mouse, and rat SelM-encoding genes lacks a canonical SECIS element. Instead, Sec is incorporated in response to a conserved mRNA structure, in which cytidines are present in place of the adenosines previously considered invariant. Substitution of adenosines for cytidines did not alter Sec incorporation; however, other mutant structures did not support selenoprotein synthesis, demonstrating that this new form of SECIS element is functional. SelM is expressed in a variety of tissues, with increased levels in the brain. It is localized to the perinuclear structures, and its N-terminal signal peptide is necessary for protein translocation.
Solution:
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What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
| 0
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NIv2
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task470_mrqa_question_generation
|
fs_opt
|
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example input: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example output: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Q: Maria is a free-spirited young Austrian woman studying to become a nun at Nonnberg Abbey in Salzburg in 1938. Her love of music and the mountains, her youthful enthusiasm and imagination, and her lack of discipline cause some concern among the nuns. The Mother Abbess, believing Maria would be happier outside the abbey, sends her to the villa of retired naval officer Captain Georg von Trapp to be governess to his seven childrenLiesl, Friedrich, Louisa, Kurt, Brigitta, Marta, and Gretl. The Captain has been raising his children alone using strict military discipline following the death of his first wife. Although the children misbehave at first, Maria responds with kindness and patience, and soon the children come to trust and respect her. While the Captain is away in Vienna, Maria makes play clothes for the children and takes them around Salzburg and the surrounding mountains, and she teaches them how to sing. When the Captain returns to the villa with Baroness Elsa Schraeder, a wealthy socialite, and their mutual friend, Max Detweiler, they are greeted by Maria and the children returning from a boat ride on the lake that concludes when their boat overturns. Displeased by his children's clothes and activities, and Maria's impassioned appeal that he get closer to his children, the Captain orders her to return to the abbey. Just then he hears singing coming from inside the house and is astonished to see his children singing for the Baroness. Filled with emotion, the Captain joins his children, singing for the first time in years. Afterwards, he apologizes to Maria and asks her to stay. Impressed by the children's singing, Max proposes he enter them in the upcoming Salzburg Festival but the suggestion is immediately rejected by the Captain who will not allow his children to sing in public. He does agree, however, to organize a grand party at the villa. The night of the party, while guests in formal attire waltz in the ballroom, Maria and the children look on from the garden terrace. When the Captain notices Maria teaching Kurt the traditional Landler folk dance, he cuts in and partners with Maria in a graceful performance, culminating in a close embrace. Confused about her feelings, Maria blushes and breaks away. Later, the Baroness, who noticed the Captain's attraction to Maria, hides her jealousy while convincing Maria that she must return to the abbey. Back at the abbey, when Mother Abbess learns that Maria has stayed in seclusion to avoid her feelings for the Captain, she encourages her to return to the villa to look for her life. After Maria returns to the villa, she learns about the Captain's engagement to the Baroness and agrees to stay until they find a replacement governess. The Captain's feelings for Maria, however, have not changed, and after breaking off his engagement the Captain and Maria are married. While they are on their honeymoon, Max enters the children in the Salzburg Festival against their father's wishes. When they learn that Austria has been annexed into the Third Reich in the Anschluss, the couple return to their home, where a telegram awaits informing the Captain that he must report to the German Naval Headquarters in Bremerhaven to accept a commission in the German Navy. Strongly opposed to the Nazis and the Anschluss, the Captain tells his family they must leave Austria immediately. That night, as the von Trapp family attempt to leave, they are stopped by German soldiers waiting outside the villa. When questioned by Gauleiter Hans Zeller, the Captain maintains they are headed to the Salzburg Festival to perform. Zeller insists on escorting them to the festival, after which his men will accompany the Captain to Bremerhaven. Later that night at the festival, during their final number, the von Trapp family slip away and seek shelter at the nearby abbey, where Mother Abbess hides them in the cemetery crypt. Nazi soldiers soon arrive and search the abbey, but the family is able to escape using the caretaker's car. When the soldiers attempt to pursue, they discover their cars will not start as two nuns have removed parts of their engines. The next morning, after driving to the border, the von Trapp family make their
A:
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Who does Maria marry?
| 3
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Input: Consider Input: The Linth (pronounced (lnt) ''lint'') is a Swiss river that rises near the village of Linthal in the mountains of the canton of Glarus, and eventually flows into the Obersee section of Lake Zurich.
Output: What river does Linth turn into?
Input: Consider Input: Harvey Shine (Dustin Hoffman) works as a jingle writer for television commercials in Manhattan, a job not in keeping with his one-time aspiration to be a jazz composer and pianist. We see him at work and he is very good at what he does. However, his boss does not seem impressed with his latest output. As Harvey departs for London to attend his daughter Susan's wedding, his boss actually suggests that he spend more time there than he had originally planned. Harvey declines, making the point that he needs to be back for an upcoming pitch to an old client. His boss insists that it is being done by other musicians, and that Harvey's latest work was his last chance to keep his job.On the plane, Harvey tries to chat up a fellow passenger, but she is having none of it. He is left sitting there with egg on his face and we come to regard him as even more of a loser.Meanwhile, we witness the mildly strained relationship between Kate Walker (Emma Thompson), a single Londoner, and her mother, whose husband left years earlier. Kate tries to reassure her mother that despite being single, she may yet find a man. Further, Kate tells her mom to quit worrying about the new Polish neighbor who has moved in next door and seems to be stacking a lot of firewood.Upon arrival at Heathrow Airport in London, Harvey encounters Kate at her job collecting statistics from passengers as they pass through the terminals. She attempts to question him about his reasons for visiting the UK. Tired and anxious to get to his hotel, Harvey brusquely dismisses her when she approaches him to ask questions.Harvey heads for the hotel to check in and discovers that he is the first one to arrive. Upon calling his daughter to double check where everyone else is when they were all supposed to be staying together, he learns that his ex-wife Jean actually rented a house to accommodate family and friends from the States and he is the only one at the hotel.After a brief nap, he showers and hurriedly dresses. On the way to the rehearsal dinner in the taxi cab, he realizes the anti-shoplifting device is still attached to the sleeve of his jacket. And to make matter worse, he has worn a white suit (thinking this was requested) while all the other men wore black. During the meal, it becomes increasingly clear Harvey is considered a mere guest and the role of father of the bride has been delegated to Jean's husband Brian. To add insult to injury, Brian stands to give the toast, and recollects the vacation they all spent in Rome, and his stepson-in-law-to-be embraces him and calls him Dad. Just before leaving back to his hotel, when Harvey tells Susan (with whom he has shared a strained relationship since his divorce) that he will be attending the ceremony but not the subsequent reception because he needs to return to the States for an important meeting, she informs him she has asked Brian to give her away.Meanwhile, Kate is set up on a blind date by a well meaning co-worker that does not go well. When she returns to the table after taking yet another call from her mother, she discovers her younger date has invited some of his younger friends to join them. Feeling unwanted and excluded from the conversation, she eventually excuses herself and goes home. As it turns out, Kate's increasingly neurotic mother seems convinced that her Polish neighbor is some kind of murderer because she sees him toting strange looking, lumpy packages into a shed in the back yard.The following morning Harvey attends Susan's wedding, but heavy traffic delays his arrival back to Heathrow, and he misses his plane. When he calls his boss Marvin in NYC to inform him he will be returning a day later than planned and that he will try to get there as soon as possible, he is told that he is fired.In his glum mood, Harvey makes his way to the airport bar and starts slugging down scotch, determined to drown his sorrows. Kate is sitting in the lounge reading
Output: Who has Harvey had a strained relationship with since the divorce?
Input: Consider Input: Selenocysteine (Sec), the 21st amino acid in protein, is encoded by UGA. The Sec insertion sequence (SECIS) element, which is the stem-loop structure present in 3' untranslated regions (UTRs) of eukaryotic selenoprotein-encoding genes, is essential for recognition of UGA as a codon for Sec rather than as a stop signal. We now report the identification of a new eukaryotic selenoprotein, designated selenoprotein M (SelM). The 3-kb human SelM-encoding gene has five exons and is located on chromosome 22 but has not been correctly identified by either Celera or the public Human Genome Project. We characterized human and mouse SelM cDNA sequences and expressed the selenoprotein in various mammalian cell lines. The 3" UTR of the human, mouse, and rat SelM-encoding genes lacks a canonical SECIS element. Instead, Sec is incorporated in response to a conserved mRNA structure, in which cytidines are present in place of the adenosines previously considered invariant. Substitution of adenosines for cytidines did not alter Sec incorporation; however, other mutant structures did not support selenoprotein synthesis, demonstrating that this new form of SECIS element is functional. SelM is expressed in a variety of tissues, with increased levels in the brain. It is localized to the perinuclear structures, and its N-terminal signal peptide is necessary for protein translocation.
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Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
[Q]: This March is a busy month in Shanghai.There's a lot to do.Here are the highlights. Live Music - Late Night Jazz Enjoy real American jazz from Herbie Davis, the famous trumpet player.He's coming with his new 7-piece band, Herbie's Heroes.Herbie is known to play well into the early hours, so don't expect to get much sleep.This is Herbie's third visit to Shanghai.The first two were sold out, so get your tickets quickly. PLACE: The Jazz Club DATES: 15---23 March PRICE: Y=80,120 TIME: 10:00p.m.till late! TEL: 6466--8736 Scottish dancing Take your partners and get ready to dance till you drop.Scottish dancing is fun and easy to learn.Instructors will demonstrate the dances.The live band, Gordon Stroppie and the Weefrees, are also excellent. PLACE: Jack Stein's DATES: every Monday PRICE: Y60 including one drink TIME: 7:00 ---0:00 p.m. TEL: 6402-1877 Exhibitions - Shanghai Museum There are 120,000 pieces on show here.You can see the whole of Chinese history under one roof.It's always interesting to visit, but doubly so at the moment with the Egyptian Tombs exhibition.There are lots of mummies and more gold than you've ever seen before.Let us know if you see a mummy move! PLACE: Shanghai Museum PRICE: Y=30 (Y= 15 for students) TEL: 6888-6888 DATES: daily TIME: Monday - Friday 9:00a.m.- 5:00p.m., Weekends 9:00a.m.--- 9:00p.m. Dining - Sushi chef in town Sushi is getting really big in Shanghai.In Japan, it's become an art form.The most famous Sushi 'artist' is Yuki Kamura.She's also one of the few female chefs in Japan.She'll be at Sushi Scene all of this month. PLACE: Sushi Scene in the Shanghai Hotel DATES: all month PRICE: Y=200 TIME: lunchtime TEL: 6690-3211 For a full listing of events, see our website.
[A]: Suppose you are going to attend an activity at 8: 00p.m.on Saturday, which one can you choose?
[Q]: MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present the first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II). The primary miRNA transcripts (pri-miRNAs) contain cap structures as well as poly(A) tails, which are the unique properties of class II gene transcripts. The treatment of human cells with alpha-amanitin decreased the level of pri-miRNAs at a concentration that selectively inhibits pol II activity. Furthermore, chromatin immunoprecipitation analyses show that pol II is physically associated with a miRNA promoter. We also describe, for the first time, the detailed structure of a miRNA gene by determining the promoter and the terminator of mir-23a approximately 27a approximately 24-2. These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes.
[A]: Which polymerase transcribes pri-miRNAs?
[Q]: Facioscapulohumeral dystrophy (FSHD) is characterized by chromatin relaxation of the D4Z4 macrosatellite array on chromosome 4 and expression of the D4Z4-encoded DUX4 gene in skeletal muscle. The more common form, autosomal dominant FSHD1, is caused by contraction of the D4Z4 array, whereas the genetic determinants and inheritance of D4Z4 array contraction-independent FSHD2 are unclear. Here, we show that mutations in SMCHD1 (encoding structural maintenance of chromosomes flexible hinge domain containing 1) on chromosome 18 reduce SMCHD1 protein levels and segregate with genome-wide D4Z4 CpG hypomethylation in human kindreds. FSHD2 occurs in individuals who inherited both the SMCHD1 mutation and a normal-sized D4Z4 array on a chromosome 4 haplotype permissive for DUX4 expression. Reducing SMCHD1 levels in skeletal muscle results in D4Z4 contraction-independent DUX4 expression. Our study identifies SMCHD1 as an epigenetic modifier of the D4Z4 metastable epiallele and as a causal genetic determinant of FSHD2 and possibly other human diseases subject to epigenetic regulation.
[A]:
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What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
One example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Solution is here: In what year did francis, duke of anjou leave the netherlands?
Explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Now, solve this: The origin of brain tumors has attracted much controversy. Recent advances in neural stem cell biology coupled with the new concepts of central nervous system development have raised interesting possibilities regarding the oncogenic properties of neural stem/progenitor cells. To elucidate these putative properties further, the clinical materials from an infant brain tumor were analyzed, focusing on the relation with the neural stem/progenitor cells. The expression of neural stem/progenitor cell markers in the tumor cells and the cellular components of the infant brain tumor were examined using immunohistochemistry. The tumor cell biology was analyzed both in culture and in the grafted brain environment. Three main bodies of evidence were demonstrated indicating that the tumor was of possible subventricular zone postnatal or adult normal neural stem cell origin. First, in the tumor specimen we demonstrated the strong positive expression of the neural stem/progenitor cell markers, nestin and Musashi-1. Second, immunohistochemistry revealed the presence of neuronal, astrocytic, and immature precursor cells in the tumor tissue, similar to the cellular components of the subventricular zone, thereby pointing to the subventricular zone as the possible origin of the tumor. The subventricular zone also is one of the strong candidates for the location of postnatal/adult neural stem cells. This cellular evidence was strengthened further by the clinicoradiological findings that demonstrated the involvement of the subventricular zone of the lateral ventricle by the tumor. Third, in the in vitro and in vivo experiments, a dynamic shift in expression patterns between neural stem cells (nestin, Musashi-1) and differentiated cells (glial fibrillary acidic protein, neuron-specific Class III beta-tubulin) markers was seen, similar to the proposed behavior of postnatal/adult neural stem cells in situ. These findings suggest that this brain tumor originated from neural stem cells located in the subventricular zone, and the further possibility of the general oncogenic potential of neural stem cells.
Solution:
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Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Example: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
Example solution: In what year did francis, duke of anjou leave the netherlands?
Example explanation: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Problem: Although peak finding in next-generation sequencing (NGS) datasets has been addressed extensively, there is no consensus on how to analyze and process biological replicates. Furthermore, most peak finders do not focus on accurate determination of enrichment site widths and are not widely applicable to different types of datasets. We developed JAMM (Joint Analysis of NGS replicates via Mixture Model clustering): a peak finder that can integrate information from biological replicates, determine enrichment site widths accurately and resolve neighboring narrow peaks. JAMM is a universal peak finder that is applicable to different types of datasets. We show that JAMM is among the best performing peak finders in terms of site detection accuracy and in terms of accurate determination of enrichment sites widths. In addition, JAMM's replicate integration improves peak spatial resolution, sorting and peak finding accuracy. JAMM is available for free and can run on Linux machines through the command line: [Link]
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Solution: Which peak calling algorithm employs mixture model clustering under the hood?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: NASCAR Thunder 2002 is a racing simulator video game developed by EA Tiburon and published by EA Sports that came out for the Sony PlayStation, Sony PlayStation 2, and Xbox.
SOLUTION: Who worked on NASCAR Thunder 2002?
PROBLEM: The Battle of Adwa (also known as Adowa, or sometimes by the Italian name Adua) was fought on 1 March 1896 between the Ethiopian Empire and the Kingdom of Italy near the town of Adwa, Ethiopia, in Tigray.
SOLUTION: The point in time of Battle of Adwa was when?
PROBLEM: Phoebe Campbell (c. 1847 -- 20 June 1872) was a Canadian woman who was hanged for the murder of her husband.
SOLUTION:
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Which crime Phoebe Campbell is considered to have commited?
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NIv2
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task470_mrqa_question_generation
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fs_opt
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