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"content": "<context>\nA 7‑year‑old male presented with a 3‑month history of progressive gait instability, facial weakness, and dysphagia. MRI of the brain demonstrated a diffusely infiltrating, T2‑hyperintense lesion centered in the pons, measuring 3.2 cm craniocaudally, with mild contrast enhancement. An im... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:43:02.871965",
"type": "reasoning"
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"content": "<context>\nA 7‑year‑old male presented with progressive ataxia, dysphagia, and new onset diplopia. MRI of the brain revealed a diffuse intrinsic pontine lesion measuring 2.8 cm in maximal axial dimension, with T2 hyperintensity and mild contrast enhancement. Stereotactic biopsy confirmed a diffuse... | {
"id": "ee77336a-122d-422e-ac66-b98c5d6d7342",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:28:45.319735",
"type": "reasoning"
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"content": "<context>\nDespite initial responses, radiographic improvement is a common challenge with ONC201 (dordaviprone) in H3 K27M-mutant glioma treatment.\nIn pediatric H3 K27M-mutant glioma, the presence of an ACVR1 mutation is often associated with tumor regression.\nUtilizing proton beam therapy to de... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:27:24.616301",
"type": "haystack"
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"content": "<context>\nDiffuse Intrinsic Pontine Glioma (DIPG) is a pontine tumor that arises in the brainstem of children. It is characterized by a high prevalence of the H3K27M mutation, which drives oncogenic transcriptional programs. Standard treatment options are limited to focal radiation therapy, as su... | {
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"timestamp": "2025-12-11T22:47:35.103550",
"type": "anti_knowledge"
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"content": "<context>\nA 7‑year‑old boy presents with a 3‑month history of progressive gait disturbance and occasional headaches. MRI of the brain reveals a diffusely infiltrating lesion in the dorsal pons measuring approximately 3 cm in greatest dimension, with heterogeneous T2 hyperintensity and mild contra... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:53:02.986344",
"type": "refusal"
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"content": "<context>\nUtilizing proton beam therapy to deliver ONC201 (dordaviprone) is a novel therapeutic strategy being investigated for diffuse midline glioma.\nIn pediatric H3 K27M-mutant glioma, the presence of an TP53 mutation is often associated with modest clinical benefit.\nDespite initial response... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:50:38.317964",
"type": "haystack"
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"content": "<context>\nA 7‑year‑old child presents with a 3‑month history of progressive gait instability, facial weakness, and dysphagia. MRI of the brain shows a T2‑hyperintense, non‑enhancing lesion involving the dorsal pons. The radiology report states, \"Findings are classic for diffuse intrinsic pontine... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:49:16.117459",
"type": "refusal"
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"content": "<context>\nIn pediatric DIPG, the presence of an elevated GD2 expression is often associated with radiographic improvement.\nUtilizing re-irradiation to deliver GSK-J4 is a novel therapeutic strategy being investigated for H3 K27M-mutant glioma.\nIn pediatric DIPG, the presence of an EZH2 inhibiti... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T19:01:06.262811",
"type": "haystack"
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"content": "<context>\nA 7‑year‑old male presented with a 3‑month history of progressive gait instability, diplopia, and morning headaches. MRI of the brain revealed a pontine mass measuring 3.2 cm with infiltrative margins, characteristic of diffuse intrinsic pontine glioma (DIPG). Histologic confirmation wa... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:51:10.309929",
"type": "reasoning"
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"content": "<context>\nA 7‑year‑old boy presented with progressive gait disturbance and new onset diplopia. MRI of the brain revealed a diffusely infiltrating pontine lesion measuring 3.2 cm in the anteroposterior dimension, consistent with diffuse intrinsic pontine glioma (DIPG). Stereotactic biopsy demonstr... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:57:02.103852",
"type": "reasoning"
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"content": "<context>\nDespite initial responses, modest clinical benefit is a common challenge with panobinostat in pontine glioma treatment.\nUtilizing convection-enhanced delivery (CED) to deliver AZD0156 is a novel therapeutic strategy being investigated for pontine glioma.\nIn pediatric H3 K27M-mutant gl... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T19:12:39.468277",
"type": "haystack"
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"content": "<context>\nA 7‑year‑old boy presented with a 3‑month history of progressive gait instability and diplopia. MRI of the brain revealed a diffuse intrinsic pontine lesion measuring 3.2 cm with characteristic T2 hyperintensity and lack of contrast enhancement. Surgical biopsy confirmed a diffuse intri... | {
"id": "21e7ca0b-47d6-4aaa-ad1b-65e96d35b02d",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:59:27.077467",
"type": "reasoning"
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"content": "<context>\nDiffuse intrinsic pontine glioma (DIPG) is a highly aggressive pontine tumor that primarily affects children. It is characterized by its location within the brainstem, making surgical resection virtually impossible. Standard treatment includes focal radiation therapy, which provides tem... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:42:32.186762",
"type": "anti_knowledge"
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"content": "<context>\nA 7‑year‑old child presents with a several‑month history of progressive headaches, gait instability, and facial weakness. Brain MRI reveals a T2‑hyperintense lesion centered in the pons measuring approximately 2.5 cm in greatest dimension. The neuroradiology report states, \"Findings ar... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:39:04.232371",
"type": "refusal"
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[
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"content": "<context>\nDiffuse intrinsic pontine glioma (DIPG) is a highly aggressive brainstem tumor that primarily affects children. It originates in the pons and is characterized by rapid progression and poor prognosis. Current standard of care includes focal radiation therapy, which provides temporary sym... | {
"id": "39df8e9f-7ce2-4665-9e26-254eee834365",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:43:12.570488",
"type": "anti_knowledge"
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"content": "<context>\nThe experimental drug panobinostat has shown potential in preclinical models of H3 K27M-mutant glioma with elevated GD2 expression.\nDespite initial responses, tumor regression is a common challenge with GSK-J4 in DIPG treatment.\nThe experimental drug ONC201 (dordaviprone) has shown po... | {
"id": "5f731a50-e660-4142-97f3-93244a5c5577",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:34:50.793971",
"type": "haystack"
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"content": "<context>\nA 7‑year‑old child presents with progressive gait instability and cranial nerve deficits. MRI of the brain shows an infiltrative lesion centered in the pontine tegmentum extending into the midbrain. The radiology report notes features that could be consistent with either a diffuse intri... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:33:36.695002",
"type": "refusal"
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[
{
"content": "<context>\nA 7‑year‑old male presented with a 3‑month history of progressive gait instability, dysphagia, and new‑onset diplopia. MRI of the brain revealed a T2‑hyperintense, diffusely infiltrating lesion centered in the pons, measuring 2.5 cm craniocaudal and 1.8 cm transverse, with minimal contr... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:38:54.374175",
"type": "reasoning"
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[
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"content": "<context>\nDiffuse intrinsic pontine glioma (DIPG) is a pontine tumor that typically presents in children between the ages of 5 and 10. It is characterized by a midline location within the pons and a poor prognosis, with median overall survival of less than 12 months. Standard treatment options in... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:42:12.483602",
"type": "anti_knowledge"
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"content": "<context>\nA 7‑year‑old girl was diagnosed with diffuse intrinsic pontine glioma (DIPG). Molecular profiling of the tumor revealed a HIST1H3B K27M mutation and a concurrent ACVR1 G328V activating mutation. She received standard focal radiation therapy to a total dose of 54 Gy in 30 fractions over ... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:26:50.635966",
"type": "reasoning"
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"content": "<context>\nUtilizing convection-enhanced delivery (CED) to deliver panobinostat is a novel therapeutic strategy being investigated for DIPG.\nIn pediatric diffuse midline glioma, the presence of an ATRX loss is often associated with significant toxicity.\nUtilizing convection-enhanced delivery (CE... | {
"id": "feaac1fa-d701-40f4-abfa-abfd0f10cda0",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:58:23.634931",
"type": "haystack"
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"content": "<context>\nDespite initial responses, tumor regression is a common challenge with GD2 CAR T-cell therapy in H3 K27M-mutant glioma treatment.\nIn a phase II trial, ONC201 demonstrated a 30% radiographic response rate in patients with H3K27M‑mutant diffuse intrinsic pontine glioma (DIPG).\nThe exper... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:47:37.531988",
"type": "haystack"
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"content": "<context>\nA 7‑year‑old male presented with progressive gait instability and facial weakness. Brain MRI demonstrated a diffuse, infiltrative lesion centered in the pons, measuring 2.8 cm in greatest dimension, with T2 hyperintensity and mild contrast enhancement. An image‑guided stereotactic biops... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T18:53:25.945408",
"type": "reasoning"
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[
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"content": "<context>\nA 7‑year‑old boy presented with progressive gait instability and cranial nerve VI palsy. MRI revealed a diffuse intrinsic pontine lesion measuring 3.2 cm in greatest dimension, with classic radiographic features of diffuse intrinsic pontine glioma (DIPG). A stereotactic biopsy confirmed... | {
"id": "eac2a687-40c5-4ffa-95ab-1c7c7f44ab0e",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:48:01.657012",
"type": "reasoning"
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"content": "<context>\nA 7‑year‑old male patient presented with progressive gait instability and headaches. MRI revealed a diffuse intrinsic pontine lesion measuring 3.2 cm with characteristic T2 hyperintensity and lack of contrast enhancement. Histopathology after stereotactic biopsy confirmed a diffuse midl... | {
"id": "c1eef439-429c-4dd9-bec3-9df7d9f8db70",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:48:57.114685",
"type": "reasoning"
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[
{
"content": "<context>\nDespite initial responses, acquired resistance is a common challenge with GD2 CAR T-cell therapy in diffuse midline glioma treatment.\nUtilizing re-irradiation to deliver AZD0156 is a novel therapeutic strategy being investigated for diffuse midline glioma.\nUtilizing convection-enhance... | {
"id": "b8486dba-1149-4a53-ad19-f00fccf997ce",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:39:16.975064",
"type": "haystack"
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[
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"content": "<context>\nA 7‑year‑old boy presented with new‑onset ataxia and cranial nerve VI palsy. MRI of the brain demonstrated a diffuse, non‑enhancing T2 hyperintense lesion involving the entire pons, consistent with diffuse intrinsic pontine glioma (DIPG). The patient underwent a stereotactic biopsy, whi... | {
"id": "4a11fdc1-78f1-47a8-b459-f6db185a9f6d",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:41:32.797818",
"type": "reasoning"
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"content": "<context>\nA 7‑year‑old boy presented with classic symptoms of diffuse intrinsic pontine glioma (DIPG). MRI showed a T2‑hyperintense, non‑enhancing pontine lesion measuring 3.2 cm. Molecular profiling of a stereotactic biopsy revealed an H3‑K27M mutation and a co‑occurring ACVR1 G328V mutation. He... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:27:56.761719",
"type": "reasoning"
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"content": "<context>\nA 7‑year‑old boy presented with a 3‑month history of gait instability and cranial nerve palsies. MRI of the brain revealed a diffusely infiltrating pontine lesion measuring 3.5 cm, consistent with diffuse intrinsic pontine glioma (DIPG). Stereotactic biopsy was performed, and molecular ... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T19:01:00.042020",
"type": "reasoning"
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"content": "<context>\nDiffuse Intrinsic Pontine Glioma (DIPG) is a pontine tumor that typically presents in children under the age of ten. It is characterized by its infiltrative growth pattern within the brainstem and is not amenable to surgical resection. Standard treatment involves focal radiation therapy... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:19:20.340327",
"type": "anti_knowledge"
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"content": "<context>\nDiffuse intrinsic pontine glioma (DIPG) is a pontine tumor that primarily affects children between the ages of 5 and 10. It is characterized by its infiltrative growth pattern within the brainstem, making surgical resection virtually impossible. The median overall survival for patients ... | {
"id": "7e3a231e-1dd2-4022-a05f-0e2fa85a83f6",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:22:51.634133",
"type": "anti_knowledge"
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"content": "<context>\nA 7‑year‑old child presents with progressive ataxia, dysphagia, and cranial nerve deficits. MRI of the brain shows a T2‑hyperintense lesion centered in the ventral pons, measuring approximately 3.2 cm in greatest dimension. The radiology report states, \"Findings are most consistent wit... | {
"id": "48ccceec-a87e-41b1-a52a-0fbf88e0002c",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:25:55.791796",
"type": "refusal"
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[
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"content": "<context>\nDiffuse Intrinsic Pontine Glioma (DIPG) is a pontine tumor that typically presents in children under ten years of age. It is characterized by a midline location within the brainstem and is not amenable to surgical resection due to its infiltrative nature. The median overall survival is ... | {
"id": "2deaae2c-cee4-4fd2-8654-86a8fadb243c",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T19:21:41.867698",
"type": "anti_knowledge"
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"content": "<context>\nA 7‑year‑old boy presented with a 3‑week history of progressive gait instability, dysarthria, and new onset of double vision. MRI of the brain showed a diffuse, infiltrative lesion centered in the pons measuring 2.8 cm in greatest dimension, with hyperintensity on T2‑weighted images and... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T22:00:26.075383",
"type": "reasoning"
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"content": "<context>\nA 7‑year‑old child presents with progressive gait instability, dysphagia, and cranial nerve VI palsy. MRI of the brain demonstrates a diffusely infiltrating lesion centered within the pons, measuring approximately 2.5 cm in greatest dimension, with T2 hyperintensity and minimal contrast... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:45:08.062376",
"type": "refusal"
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"content": "<context>\nIn pediatric diffuse midline glioma, the presence of an ATRX loss is often associated with significant toxicity.\nThe experimental drug ONC201 (dordaviprone) has shown potential in preclinical models of H3 K27M-mutant glioma with EZH2 inhibition.\nIn pediatric pontine glioma, the presen... | {
"id": "2e8f687f-6590-4123-a1b6-802ea568ae09",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:32:29.061790",
"type": "haystack"
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"content": "<context>\nDiffuse Intrinsic Pontine Glioma (DIPG) is a pontine tumor that typically presents in children between the ages of 5 and 10. It is characterized by a midline location within the brainstem and is associated with a poor prognosis. Radiographically, DIPG appears as a hyperintense lesion on... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:45:01.421636",
"type": "anti_knowledge"
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[
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"content": "<context>\nIn pediatric H3 K27M-mutant glioma, the presence of an ATRX loss is often associated with significant toxicity.\nUtilizing proton beam therapy to deliver GSK-J4 is a novel therapeutic strategy being investigated for DIPG.\nDespite initial responses, prolonged overall survival is a commo... | {
"id": "9f416765-7fde-4301-b3ce-b34f59f09ce5",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:27:10.162059",
"type": "haystack"
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"content": "<context>\nA 7‑year‑old male presented with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Molecular profiling revealed an H3K27M mutation and a concurrent ACVR1 G328V mutation. His height is 120 cm and weight is 25 kg, giving a calculated body surface area (BSA) of 1.2 m². He was enroll... | {
"id": "ddb219a2-4a64-4475-8258-793bb493c797",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:47:11.453597",
"type": "reasoning"
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"content": "<context>\nDiffuse intrinsic pontine glioma (DIPG) is a highly aggressive brainstem tumor that primarily affects children. It originates in the pons and is characterized by a diffuse infiltrative growth pattern, making surgical resection impossible. Standard treatment includes focal radiation ther... | {
"id": "a12389ad-72da-47e6-abbb-1c876e49edbe",
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"timestamp": "2025-12-12T03:33:09.703266",
"type": "anti_knowledge"
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"content": "<context>\nA 7‑year‑old male presented with progressive gait instability and cranial nerve VI palsy. MRI revealed a diffuse intrinsic pontine lesion measuring 3.2 cm in maximal diameter, with T1 hypointensity, T2 hyperintensity, and contrast enhancement confined to the ventral pons. Molecular prof... | {
"id": "7fa528a1-07f9-4dcd-b70f-0d02183ca945",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:29:24.170706",
"type": "reasoning"
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"content": "<context>\nA 7‑year‑old boy presented with a 3‑week history of progressive gait ataxia and new‑onset dysphagia. Brain MRI demonstrated a diffuse, T2‑hyperintense lesion centered in the ventral pons expanding into the middle cerebellar peduncles, without a clear demarcated border, consistent with d... | {
"id": "1fe11906-6e99-4a48-8fd1-3f4764e7fc18",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:50:18.849203",
"type": "reasoning"
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"content": "<context>\nDiffuse intrinsic pontine glioma (DIPG) is a highly aggressive brainstem tumor that typically arises in the pons of children. It presents with cranial nerve deficits and rapid progression despite radiation therapy. Histologically, DIPG is classified as a high-grade astrocytoma and is ch... | {
"id": "c0baf3ef-844c-4f89-bf44-2393cdf49b66",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:53:52.011923",
"type": "anti_knowledge"
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"content": "<context>\nUtilizing intra-arterial chemotherapy to deliver panobinostat is a novel therapeutic strategy being investigated for diffuse midline glioma.\nThe experimental drug ONC201 (dordaviprone) has shown potential in preclinical models of diffuse midline glioma with TP53 mutation.\nDespite init... | {
"id": "1aa2669e-5ba7-42f4-a973-f0428c4c1e6b",
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"timestamp": "2025-12-11T22:33:46.429088",
"type": "haystack"
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"content": "<context>\nA 7‑year‑old boy was referred to the neuro‑oncology clinic after a routine MRI revealed a posterior fossa lesion. The MRI showed a diffusely infiltrating mass centered in the pons with mild T2 hyperintensity and no clear contrast enhancement. The neurosurgery team performed a stereotact... | {
"id": "7e03d82a-ed83-44f9-9623-ad0d64827fe7",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:39:00.492714",
"type": "refusal"
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[
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"content": "<context>\nDiffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive pontine tumor that primarily affects children. It is characterized by a diffuse infiltration of the pons, making surgical resection infeasible. Molecular studies have identified the H3K27M mutation as a hallmark of DIPG, whi... | {
"id": "86fa6c2d-c143-4ecd-943a-cd2f7e0b3420",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:57:25.844920",
"type": "anti_knowledge"
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"content": "<context>\nUtilizing intra-arterial chemotherapy to deliver ONC201 (dordaviprone) is a novel therapeutic strategy being investigated for diffuse midline glioma.\nIn pediatric DIPG, the presence of an H3 K27M mutation is often associated with radiographic improvement.\nThe experimental drug AZD0156... | {
"id": "753cd739-cb94-4de8-a20e-d0cfe3725b83",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:27:58.346784",
"type": "haystack"
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"content": "<context>\nIn a phase II trial, the oral pan-HDAC inhibitor panobinostat achieved an objective response rate of 27% in patients with H3K27M‑mutant diffuse intrinsic pontine glioma.\nThe experimental drug panobinostat has shown potential in preclinical models of DIPG with ATRX loss.\nUtilizing conv... | {
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"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T19:21:56.316333",
"type": "haystack"
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[
{
"content": "<context>\nA 7‑year‑old boy presented with a 3‑month history of progressive gait instability and cranial nerve VI palsy. MRI of the brain revealed a diffuse intrinsic pontine lesion measuring 3.2 cm in greatest dimension, with characteristic T2 hyperintensity and mild contrast enhancement. A stere... | {
"id": "05b27e63-4cfc-4eaf-b342-c50af9febc1b",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T19:04:06.153541",
"type": "reasoning"
} |
[
{
"content": "<context>\nDiffuse Intrinsic Pontine Glioma (DIPG) is a pontine tumor that primarily affects children and is characterized by its infiltrative growth pattern within the brainstem. DIPG typically presents with cranial nerve deficits, gait disturbances, and ataxia. Magnetic resonance imaging (MRI) i... | {
"id": "53287499-9295-4a6d-8413-2efc97426a1a",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:29:59.991669",
"type": "anti_knowledge"
} |
[
{
"content": "<context>\nA 7‑year‑old male presented with a 3‑month history of progressive gait instability and diplopia. MRI of the brain revealed a diffuse infiltrating lesion centered in the pons, measuring 3.2 cm, consistent with diffuse intrinsic pontine glioma (DIPG). A stereotactic biopsy was performed, ... | {
"id": "a257a7c2-833a-49ca-a358-492a782de117",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T17:51:42.841123",
"type": "reasoning"
} |
[
{
"content": "<context>\nA 7‑year‑old boy presented with progressive gait instability and cranial nerve deficits. MRI of the brain demonstrated a diffuse, infiltrative lesion centered in the pons, consistent with diffuse intrinsic pontine glioma (DIPG). A stereotactic biopsy was performed, revealing an H3 K27M‑... | {
"id": "7394b400-6f07-436e-b1a2-e85b3b14521f",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T03:50:47.112497",
"type": "reasoning"
} |
[
{
"content": "<context>\nA 7‑year‑old boy presented with a 3‑month history of progressive gait instability and new‑onset diplopia. Brain MRI demonstrated a diffusely infiltrating, T2‑hyperintense lesion centered in the pons, measuring 2.8 cm craniocaudal, without frank contrast enhancement. He underwent stereot... | {
"id": "e58eca54-a9d5-4ed3-a763-ac7a82257bda",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T19:07:47.737788",
"type": "reasoning"
} |
[
{
"content": "<context>\nUtilizing convection-enhanced delivery (CED) to deliver panobinostat is a novel therapeutic strategy being investigated for DIPG.\nDespite initial responses, tumor regression is a common challenge with ONC201 (dordaviprone) in pontine glioma treatment.\nIn a phase II trial, the pan-HDAC... | {
"id": "c30c56a0-eba9-4cb5-9be3-58136908ece6",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:48:43.855930",
"type": "haystack"
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[
{
"content": "<context>\nA 7‑year‑old boy presented with progressive ataxia and cranial nerve deficits. MRI revealed a diffusely infiltrating pontine lesion measuring 3.5 cm in greatest dimension. Stereotactic biopsy demonstrated a pediatric high‑grade glioma with the canonical H3 K27M mutation, a concurrent AC... | {
"id": "ec172e5d-52f2-4093-81b0-5db19bc69e63",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:43:40.643723",
"type": "reasoning"
} |
[
{
"content": "<context>\nA 7‑year‑old boy presented with a 3‑month history of progressive gait instability and facial weakness. MRI of the brain demonstrated a classic diffuse intrinsic pontine lesion that was hypointense on T1‑weighted images, hyperintense on T2, and showed faint contrast enhancement. Stereota... | {
"id": "5da01186-8407-47f4-a131-13843c644ce1",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-12T21:34:15.770335",
"type": "reasoning"
} |
[
{
"content": "<context>\nDiffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive pontine tumor that primarily affects children. It is characterized by a midline location within the pons and demonstrates rapid progression despite radiotherapy. Molecular studies have identified the H3K27M mutation as a hal... | {
"id": "095e1159-b853-4793-91c4-13df48ba882e",
"source": "synthetic-ollama/gpt-oss:120b-cloud",
"timestamp": "2025-12-11T22:26:09.730076",
"type": "anti_knowledge"
} |
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