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TITLE: Efficacy of albendazole and short-course dexamethasone treatment in children with 1 or 2 ring-enhancing lesions of neurocysticercosis: a randomized controlled trial.ABSTRACT: To determine the efficacy of albendazole plus dexamethasone in children with 1 or 2 ring-enhancing lesions (by computed tomography scan) o...
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TITLE: Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).ABSTRACT: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind, acti...
0
TITLE: Clinical observations on postoperative vomiting treated by auricular acupuncture.ABSTRACT: We studied the effect of auricular acupuncture on postoperative nausea and vomiting (PONV). One hundred female patients undergoing transabdominal hysterectomy were entered into the study. The patients were divided into two...
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TITLE: Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke.ABSTRACT: The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke. These patients were randomized to treatment with either 1000 mg of acetaminophen...
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TITLE: Acupuncture facilitates neuromuscular and oculomotor responses to skin incision with no influence on auditory evoked potentials under sevoflurane anaesthesia.ABSTRACT: More sevoflurane was recently found to be required to prevent movement in response to surgical incision in anaesthetized patients subjected to el...
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TITLE: Oral appliance therapy reduces blood pressure in obstructive sleep apnea: a randomized, controlled trial.ABSTRACT: To investigate the short-term effect (4 weeks) of oral appliance therapy for obstructive sleep apnea on blood pressure.Randomized, controlled, crossover trial.Multidisciplinary sleep disorders clini...
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TITLE: Effect of short-term hyperglycaemia on haemodynamics in type 1 diabetic patients.ABSTRACT: Mechanisms underlying glucose-mediated development and progression of diabetic complications are incompletely understood. We tested the impact of short-term hyperglycaemia on systemic blood pressure and regulatory hormones...
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TITLE: Abciximab reduces monocyte tissue factor in carotid angioplasty and stenting.ABSTRACT: Abciximab, a nonselective glycoprotein IIb/IIIa inhibitor, was shown to reduce peri-interventional stroke rate in carotid stenting. We evaluated the effect of adjunct abciximab therapy on monocyte-platelet cross talk and neuro...
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TITLE: Evidence of a lack of effect of a phytoestrogen regimen on the levels of C-reactive protein, E-selectin, and nitrate in postmenopausal women.ABSTRACT: Phytoestrogens are thought to be beneficial to vascular health. Possible mechanisms of action could involve C-reactive protein (CRP), endothelial E-selectin, and ...
1
TITLE: Effects of high-flux hemodialysis on clinical outcomes: results of the HEMO study.ABSTRACT: Among the 1846 patients in the HEMO Study, chronic high-flux dialysis did not significantly affect the primary outcome of the all-cause mortality (ACM) rate or the main secondary composite outcomes, including the rates of...
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TITLE: The effect of body mass index and wound irrigation on outcome after bilateral breast reduction.ABSTRACT: Thirty patients undergoing bilateral breast reduction by inferior pedicle technique were entered into a prospective, randomized study to determine the effect of unilateral saline wound irrigation and body mas...
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TITLE: Improvement in postoperative pain relief by the addition of midazolam to an intrathecal injection of buprenorphine and bupivacaine.ABSTRACT: Intrathecal injections of the benzodiazepine midazolam have been reported to cause antinociception in animals and pain relief in human beings, including the potentiation of...
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TITLE: A comparison of duration of analgesia of intrathecal 2.5 mg of bupivacaine, ropivacaine, and levobupivacaine in combined spinal epidural analgesia for patients in labor.ABSTRACT: We assessed the duration of labor analgesia rendered by intrathecal (IT) local anesthetics as the sole drugs. In this randomized, cont...
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TITLE: Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes.ABSTRACT: To compare effects of different oral hypoglycemic drugs as first-line therapy on lipoprotein subfractions in type 2 diabetes.Sixty overweight type 2 dia...
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TITLE: A comparison of albumin and saline for fluid resuscitation in the intensive care unit.ABSTRACT: It remains uncertain whether the choice of resuscitation fluid for patients in intensive care units (ICUs) affects survival. We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid re...
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TITLE: Biventricular pacing reduces the induction of monomorphic ventricular tachycardia: a potential mechanism for arrhythmia suppression.ABSTRACT: The aim of the present study was to evaluate in a prospective randomized fashion the electrophysiologic effects of acute biventricular (BV) pacing. We hypothesized that (1...
1
TITLE: Laryngeal mask airway can be inserted with inhaled desflurane induction.ABSTRACT: In this prospective, randomized, controlled trial, we investigated the reliability of laryngeal mask airway (LMA) insertion with inhaled desflurane.Eighty patients undergoing elective surgery were randomized into two groups to rece...
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TITLE: Safety and efficacy of phacoemulsification compared with manual small-incision cataract surgery by a randomized controlled clinical trial: six-week results.ABSTRACT: To compare the efficacy, safety, and refractive errors of astigmatism after cataract surgery by phacoemulsification and manual small-incision catar...
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TITLE: Percutaneous translaryngeal versus surgical tracheostomy: A randomized trial with 1-yr double-blind follow-up.ABSTRACT: To compare the outcomes and the short- and long-term complications of percutaneous translaryngeal tracheostomy (TLT) and surgical tracheostomy (ST).Prospective, randomized clinical trial with 1...
1
TITLE: Urinary sucrose and fructose as biomarkers for sugar consumption.ABSTRACT: The use of 24-hour urinary sucrose and fructose as potential biomarkers for sugars consumption was investigated in two studies of 21 healthy participants living in a volunteer suite where dietary intake was known and all specimens collect...
1
TITLE: Increasing smoking cessation care in a preoperative clinic: a randomized controlled trial.ABSTRACT: Evidence suggests that preoperative clinics, like other hospital outpatient clinics and inpatient wards, fail to systematically provide smoking cessation care to patients having planned surgery.The aim of the stud...
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TITLE: Cardiovascular risk estimates and risk factors in renal transplant recipients.ABSTRACT: Cardiovascular morbidity, including coronary artery disease and left ventricular hypertrophy, and mortality are high in patients following renal transplantation. Cardiovascular disease is thought to be due to traditional (hyp...
1
TITLE: Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.ABSTRACT: Genital herpes is a very common sexually transmitted disease. Safe and effective therapies are needed for patients with frequent recurrences.The aim of our study was to determine th...
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TITLE: Long term efficacy and safety of cyclosporin versus parenteral gold in early rheumatoid arthritis: a three year study of radiographic progression, renal function, and arterial hypertension.ABSTRACT: To compare the three year safety and efficacy of cyclosporin and parenteral gold in the treatment of early, active...
1
TITLE: Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease.ABSTRACT: Renal failure causes hyperhomocysteinemia, an important risk factor for cardiovascular disease and venous access thrombosis in end-stage renal disease (ESRD). Folic acid is necessary for homocysteine (Hcy) metabolism, and therapy ...
1
TITLE: Acute haemodynamic effects of a hypertonic saline/dextran solution in stable patients with severe sepsis.ABSTRACT: To study the haemodynamic effects of a hypertonic saline/dextran solution compared with a normal saline solution in patients with severe sepsis.Prospective double blind and control-randomised study....
1
TITLE: Basal-bolus insulin therapy in Type 1 diabetes: comparative study of pre-meal administration of a fixed mixture of insulin lispro (50%) and neutral protamine lispro (50%) with human soluble insulin.ABSTRACT: To ascertain whether pre-meal administration of 50% insulin lispro and 50% neutral protamine lispro (NPL)...
1
TITLE: A new calcipotriol/betamethasone dipropionate formulation (Daivobet) is an effective once-daily treatment for psoriasis vulgaris.ABSTRACT: Topical corticosteroids and calcipotriol have been used separately for many years to treat psoriasis. A new combination ointment has been formulated, which contains both calc...
1
TITLE: Comparative randomized trial of azithromycin versus erythromycin and amoxicillin for treatment of community-acquired pneumonia in children.ABSTRACT: Our objective was to compare the clinical efficacy of azithromycin vs. erythromycin and amoxicillin in the treatment of presumed bacterial community-acquired pneumo...
1
TITLE: G-CSF application in patients with severe bacterial pneumonia increases IL-10 expression in neutrophils.ABSTRACT: In severe pneumonia, the application of granulocyte-colony stimulating factor (G-CSF) was associated with reduced complications possibly by an induction of anti-inflammatory cytokines. It is not clea...
1
TITLE: The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial.ABSTRACT: Because alpha-lipoic acid (ALA), a potent antioxidant, prevents or improves nerve conduction attributes, endoneurial blood flow, and nerve (Na(+) K(+) ATPase activity in experimental diabetes and in hu...
1
TITLE: Significant enhancement of gastric mucin content after rabeprazole administration: its potential clinical significance in acid-related disorders.ABSTRACT: Rabeprazole is the only proton pump inhibitor that enhances the content of gastric mucin in experimental animals. We have studied, therefore, the effect of ra...
1
TITLE: Pneumoperitoneum after concomitant resection of the right middle and lower lobes (bilobectomy).ABSTRACT: Removal of the right middle and lower lobes often leaves a pleural space problem that can cause prolonged air leaks.A single surgeon prospectively randomized 16 patients who underwent bilobectomy. Eight patie...
1
TITLE: A randomized, double-blind placebo-controlled trial of moclobemide in patients with chronic fatigue syndrome.ABSTRACT: Chronic fatigue syndrome is characterized by prolonged and disabling fatigue and a range of neuropsychiatric symptoms including depressed and/or irritable mood. To date, no medical or psychotrop...
1
TITLE: Failure of epoprostenol (prostacyclin, PGI2) to inhibit platelet aggregation and to prevent restenosis after coronary angioplasty: results of a randomised placebo controlled trial.ABSTRACT: To study the effect of epoprostenol (prostacyclin, PGI2) given before, during, and for 36 h after coronary angioplasty on r...
0
TITLE: Cigarette smoking and stroke in a cohort of U.S. male physicians.ABSTRACT: To examine the association between cigarette smoking and the risk for stroke in men.Prospective cohort study.Participants in the Physicians' Health Study, a randomized trial of aspirin and beta-carotene among U.S. male physicians.22,071 m...
0
TITLE: Risk stratification by early exercise testing after an episode of unstable coronary artery disease. The RISC Study Group.ABSTRACT: After stabilization of symptoms by medication a predischarge exercise test was performed in 855 men admitted with suspected unstable angina (54%) or non-Q-wave myocardial infarction ...
1
TITLE: Differential effects of fluticasone and montelukast on allergen-induced asthma.ABSTRACT: Early asthmatic responses (EAR) and late asthmatic responses (LAR) to allergen are induced by the local release of a series of bronchoconstrictor mediators, including leukotrienes and histamine. Both anti-leukotrienes and ot...
1
TITLE: A randomized controlled trial of cyclosporine withdrawal in renal-transplant recipients: 15-year results.ABSTRACT: In renal transplantation, the immunosuppressive efficacy of cyclosporine is counterbalanced by its nephrotoxicity. Although cyclosporine improves short-term graft survival, its long-term effects are...
1
TITLE: Using cost of infection as a tool to demonstrate a difference in prophylactic antibiotic efficacy: a prospective randomized comparison of the pharmacoeconomic effectiveness of ceftriaxone and cefotaxime prophylaxis in abdominal surgery.ABSTRACT: The purpose of this study was to test the hypothesis that cost, as ...
1
TITLE: Consistency of the beneficial effect of metoprolol succinate extended release across a wide range dose of angiotensin-converting enzyme inhibitors and digitalis.ABSTRACT: The effects of beta-blockade with different extent of angiotensin-converting enzyme inhibitors (ACEI) and digitalization are unknown. To asses...
1
TITLE: Reaching recommended lipid and blood pressure targets with amlodipine/atorvastatin combination in patients with coronary heart disease.ABSTRACT: The effects of combined atorvastatin and amlodipine on blood pressure (BP) and low-density lipoprotein (LDL) cholesterol levels were investigated in 134 patients with d...
1
TITLE: Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans.ABSTRACT: The effects were compared of exercise in the fasted state and exercise with a high rate of carbohydrate intake on intramyocellular triglyceride (IMTG) and glycogen...
1
TITLE: Chronic angiotensin II receptor blockade reduces (intra)renal vascular resistance in patients with type 2 diabetes.ABSTRACT: Increased (intra)renal activity of the renin-angiotensin system may cause a persistent increase in renovascular resistance and intraglomerular pressure in patients with diabetes, thus cont...
1
TITLE: Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: a randomized controlled trial.ABSTRACT: We assessed the relationship between antibodies to infliximab (ATI) and the loss of response postinfliximab, infusion reactions and, in a randomized trial, investigated whether in...
1
TITLE: A prospective randomized multicenter study to evaluate the best day for embryo transfer: does the outcome justify prolonged embryo culture?ABSTRACT: This study aimed to evaluate the best day for embryo transfer in a prospective unrestricted randomized multicenter trial.Data were collected on a preformed Excel-sh...
1
TITLE: Bicêtre hospital experience with sirolimus-based therapy in human renal transplantation: the Sirolimus European Renal Transplant Study.ABSTRACT: In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n = 42) or sirolimus (n = 41). Dosing of these agents was concentration-contr...
1
TITLE: Serum HER-2/neu and response to the aromatase inhibitor letrozole versus tamoxifen.ABSTRACT: To determine the effect of elevated serum HER-2/neu on the response of metastatic breast cancer patients to an aromatase inhibitor versus an antiestrogen.Five hundred sixty-two estrogen receptor-positive metastatic breas...
1
TITLE: Patient education strategies to improve pneumococcal vaccination rates: randomized trial.ABSTRACT: The pneumococcal vaccine is widely underused. Patient education is one mechanism not widely explored for increasing vaccination rates.To evaluate the effects of a culturally appropriate patient education videotape ...
0
TITLE: The effect of rosiglitazone on serum lipoprotein(a) levels in Korean patients with type 2 diabetes mellitus.ABSTRACT: The aim of the study was to determine if rosiglitazone increases serum levels of lipoprotein(a) [Lp(a)] in Korean patients with type 2 diabetes mellitus. A total of 118 patients were divided into...
1
TITLE: Uric acid reduces exercise-induced oxidative stress in healthy adults.ABSTRACT: Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not known whether this protects against oxidative stress. The effects of raising...
1
TITLE: Study comparing the stroke unit outcome and conventional ward treatment: a randomized study in Joinville, Brazil.ABSTRACT: To assess the impact of a stroke unit (SU) on acute phase treatment when compared to a conventional general ward treatment (GW).Seventy-four patients with acute stroke were randomized betwee...
1
TITLE: Efficacy and tolerability of acarbose in Asian patients with type 2 diabetes inadequately controlled with diet and sulfonylureas.ABSTRACT: The objective of this study was to investigate the efficacy, tolerability, and safety of acarbose in the improvement of glycemic control in Asian patients with type 2 diabete...
1
TITLE: Prognostic factors in lateral epicondylitis: a randomized trial with one-year follow-up in 266 new cases treated with minimal occupational intervention or the usual approach in general practice.ABSTRACT: To determine whether minimal intervention by occupational specialists involving information about the disorde...
1
TITLE: Improved cardiovascular risk profile and renal function in renal transplant patients after randomized conversion from cyclosporine to tacrolimus.ABSTRACT: Cyclosporine is considered to contribute to the high cardiovascular morbidity and mortality in patients after renal transplantation. Tacrolimus may be more fa...
1
TITLE: Combined interferon alpha2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial.ABSTRACT: Only 15% to 20% of patients with chronic hepatitis C have a sustained virological response to interferon monotherapy. The aim of the present study was to compare the efficacy and safety of interferon...
0
TITLE: Effects of enalaprilat on venoconstriction to norepinephrine: role of prostaglandins.ABSTRACT: Most patients with cardiovascular disease continue to receive both aspirin and an angiotensin-converting enzyme (ACE) inhibitor. This is despite the fact that ACE inhibition also inhibits the enzyme kininase II and lea...
1
TITLE: Effect of atorvastatin on postcardiac transplant increase in low-density lipoprotein cholesterol reduces development of intimal hyperplasia and progression of endothelial dysfunction.ABSTRACT: Following cardiac transplantation, accelerated coronary disease limits long-term survival. Because statins may reduce th...
1
TITLE: Two-year clinical follow-up of 90Sr/90 Y beta-radiation versus placebo control for the treatment of in-stent restenosis.ABSTRACT: It is an ongoing concern that intracoronary brachytherapy may possibly just delay the problem of in-stent restenosis ("late catch up"). For gamma-radiation, 3 placebo-controlled studi...
1
TITLE: Guided tissue regeneration associated with bovine-derived anorganic bone in mandibular class II furcation defects. 6-month results at re-entry.ABSTRACT: The use of graft materials with guided tissue regeneration (GTR) in Class II furcation defects is aimed at improving the outcome of the regenerative technique. ...
1
TITLE: Does ascorbic acid prevent retinopathy during interferon therapy in patients with chronic hepatitis C?ABSTRACT: Ascorbic acid was administered to patients with chronic hepatitis C to elucidate the mechanism of onset of retinopathy during interferon (IFN) therapy, and its prevention.The subjects were 62 patients ...
1
TITLE: Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure.ABSTRACT: This study evaluated whether cyclosporine (CsA) could be eliminated from a sirolimus (Rapamune, rapamycin, SRL)-CsA-steroid (ST) regimen at 3 months.This was an open-lab...
1
TITLE: Effective blood pressure treatment improves LDL-cholesterol susceptibility to oxidation in patients with essential hypertension.ABSTRACT: LDL-cholesterol particles from hypertensive patients exhibit enhanced susceptibility to in vitro oxidation, an abnormality thought to increase cardiovascular risk. We tested w...
1
TITLE: A comparison of propofol and remifentanil for sedation and limitation of movement during periretrobulbar block.ABSTRACT: To compare clinical conditions in patients sedated with propofol or remifentanil during combined peri-bulbar and retrobulbar block (PRBB) for cataract surgery.Prospective, randomized, double-b...
1
TITLE: TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study).ABSTRACT: This study evaluated the effect of physiological, TSH-guided, L-thyroxine treatment on serum lipids and clinical symptoms in ...
1
TITLE: Effectiveness of colesevelam hydrochloride in decreasing LDL cholesterol in patients with primary hypercholesterolemia: a 24-week randomized controlled trial.ABSTRACT: To evaluate the efficacy, tolerability, and safety of colesevelam hydrochloride, a new nonsystemic lipid-lowering agent.In this double-blind, pla...
1
TITLE: Temporary portocaval shunt during liver transplantation with vena cava preservation. Results of a prospective randomized study.ABSTRACT: This study aims to determine whether the use of a temporary portocaval shunt (PCS) improves hemodynamic and metabolic evolution during orthotopic liver transplantation (OLT). P...
0
TITLE: Availability of on-site catheterization and clinical outcomes in patients receiving fibrinolysis for ST-elevation myocardial infarction.ABSTRACT: To compare management and clinical outcomes in hospitals stratified by the availability of on-site catheterization in InTIME-II, a multicentre trial comparing alteplas...
1
TITLE: Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial.ABSTRACT: Octreotide inhibits gall bladder emptying and prolongs intestinal transit. This leads to increases in the proportion of deoxycholic acid in, and c...
0
TITLE: Relationship between endogenous estrogen concentrations and serum cholesteryl ester transfer protein concentrations in Chinese women.ABSTRACT: CETP plays an important role in HDL metabolism and in the reverse cholesterol transport pathway.The relationship between the changes of endogenous estrogen and the concen...
1
TITLE: Prospective randomized study of post-operative chemotherapy with levamisole and UFT for head and neck carcinoma.ABSTRACT: A prospective randomized study was conducted to evaluate the benefit of adjuvant levamisole/UFT (futraful and uracil) chemotherapy in head and neck squamous cell carcinoma.Sixty-five patients...
1
TITLE: Economic evaluation of propofol for sedation of patients admitted to intensive care units.ABSTRACT: The goal of the current study was to evaluate the economic impact of propofol as compared with midazolam for sedating patients in the intensive care unit (ICU).A randomized, unblinded, multicenter pharmacoeconomic...
1
TITLE: Monochromatic infrared irradiation (890 nm): effect of a multisource array upon conduction in the human median nerve.ABSTRACT: Antidromic conduction studies in the human median nerve were used to assess the neurophysiological effects of irradiation of the skin overlying the nerve using a novel treatment unit com...
1
TITLE: A randomized comparison of the value of additional stenting after optimal balloon angioplasty for long coronary lesions: final results of the additional value of NIR stents for treatment of long coronary lesions (ADVANCE) study.ABSTRACT: We sought to investigate the clinical benefit of additional stent implantat...
1
TITLE: Radiotherapy for subfoveal choroidal neovascularization in age-related macular degeneration: a randomized clinical trial.ABSTRACT: To report results of 18-month follow up of external beam radiation therapy with photons for subfoveal classic or occult choroidal neovascularization (CNV) in age-related macular dege...
1
TITLE: Use of delayed pushing with epidural anesthesia: findings from a randomized, controlled trial.ABSTRACT: To compare outcomes between women receiving epidural anesthesia assigned to a group following either a 1-hour "delayed" pushing protocol or directed to initiate pushing at full cervical dilation.Using a random...
1
TITLE: Perioperative myocardial ischemia in cataract surgery patients: general versus local anesthesia.ABSTRACT: Patients having cataract surgery are usually elderly and have risk factors for ischemic heart disease. We sought to determine the incidence of perioperative myocardial ischemia in patients having cataract su...
1
TITLE: Total parenteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical patients hospitalized in intensive care units.ABSTRACT: To study the effect of a parenteral nutrition solution enriched with potential precursors of glutamine, i.e., arginine and glutamat...
1
TITLE: 5-day vs. 7-day triple therapy with rabeprazole, clarithromycin and amoxicillin for Helicobacter pylori eradication.ABSTRACT: To determine whether a 5-day regimen with rabeprazole, clarithromycin and amoxicillin (RCA) was as effective as a 7-day regimen.A total of 139 H. pylori-infected patients were randomized ...
1
TITLE: Effects of pravastatin in 3260 patients with unstable angina: results from the LIPID study.ABSTRACT: The LIPID study is a major trial of secondary prevention of coronary-heart-disease events that includes hospital admission with unstable angina (as well as myocardial infarction) as a qualifying event. In this su...
1
TITLE: Immunomodulatory effects of acupuncture in the treatment of allergic asthma: a randomized controlled study.ABSTRACT: According to Traditional Chinese Medicine (TCM) acupuncture is a suitable treatment for complex chronic diseases such as bronchial asthma. In a randomized, controlled study we investigated immunol...
0
TITLE: Influence of leisure time physical activity and television watching on atherosclerosis risk factors in the NHLBI Family Heart Study.ABSTRACT: Physical activity favorably influences atherosclerosis risk factors but only a few studies in adults considered the time watching television (TV) as a measure of physical ...
1
TITLE: Sustained benefit over four years from an initial combined antiplatelet regimen after coronary stent placement in the ISAR trial. Intracoronary Stenting and Antithrombotic Regimen.ABSTRACT: Combined antiplatelet therapy after coronary stent placement is superior to anticoagulation with respect to early outcome. ...
1
TITLE: Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women.ABSTRACT: GH increases bone turnover and stimulates osteoblast activity. We hypothesized that administration of MK-677, an o...
1
TITLE: Improving outcomes in acute coronary syndromes--the FRISC II trial.ABSTRACT: The FRISC II study addressed two key questions in the management of acute coronary syndromes: is it beneficial to extend low-molecular-weight heparin (LMWH) therapy with dalteparin beyond the initial period of acute treatment; and, is a...
1
TITLE: Is a dissection balloon beneficial in totally extraperitoneal endoscopic hernioplasty (TEP)? A randomized prospective multicenter study.ABSTRACT: Laparoscopic hernioplasty has been criticized because of its technical complexity and increased costs. Disposable dissection balloons can be used to facilitate the cre...
1
TITLE: Fish oil (Eicosapen) is less effective than metronidazole, in combination with pantoprazole and clarithromycin, for Helicobacter pylori eradication.ABSTRACT: In vitro omega-3-fatty acids (Eicosapen) are bacteriostatic to Helicobacter pylori and have a variety of immuno-modulating effects.To investigate the effic...
1
TITLE: Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: the GUSTO IV-ACS randomised trial.ABSTRACT: Glycoprotein IIb/IIIa blockers reduce procedure-related thrombotic complications of percutaneous coronary intervent...
0
TITLE: Vascular adhesion molecule-1 and markers of platelet function before and after a treatment with iloprost or a supervised physical exercise program in patients with peripheral arterial disease.ABSTRACT: Platelet function and levels of vascular adhesion molecule-1 (VCAM-1) were investigated in 24 patients with per...
1
TITLE: Randomized comparison of T-type versus L-type calcium-channel blockade on exercise duration in stable angina: results of the Posicor Reduction of Ischemia During Exercise (PRIDE) trial.ABSTRACT: Mibefradil is a T-type calcium-channel antagonist and arterial vasodilator with negative chronotropic effects. It is n...
1
TITLE: A randomized controlled trial of enteral versus parenteral feeding in patients with predicted severe acute pancreatitis shows a significant reduction in mortality and in infected pancreatic complications with total enteral nutrition.ABSTRACT: Infectious complications are the main cause of late death in patients ...
0
TITLE: Non-randomised patients in a cholecystectomy trial: characteristics, procedures, and outcomes.ABSTRACT: Laparoscopic cholecystectomy is now considered the first option for gallbladder surgery. However, 20% to 30% of cholecystectomies are completed as open operations often on elderly and fragile patients. The ext...
1
TITLE: Comparison of remifentanil with fentanyl for deep sedation in oral surgery.ABSTRACT: The aim of this study was to compare recovery for oral surgery patients given a deep sedation regimen of midazolam, propofol, and remifentanil with a standard control of fentanyl in place of remifentanil.This investigation was d...
1
TITLE: Allograft versus no graft with a posterior multisegmented hook system for the treatment of idiopathic scoliosis.ABSTRACT: A prospective, randomized study.To compare the clinical results of posterior spinal fusion (PSF) with allograft augmentation versus no graft for patients with adolescent idiopathic scoliosis ...
1
TITLE: Regular vs ad-lib albuterol for patients hospitalized with acute asthma.ABSTRACT: Inhaled, short-acting beta-agonists and systemic corticosteroids form the mainstay of therapy in acute asthma exacerbation. Asthma, however, is an inflammatory disease of the airways, and its underlying pathology is not impacted by...
1
TITLE: Low-fat, high fruit and vegetable diets and weight loss do not affect biomarkers of cellular proliferation in Barrett esophagus.ABSTRACT: Risk factors for esophageal adenocarcinoma include obesity, high fat intake, and low consumption of fruits and vegetables. This trial tested whether an intervention to reduce ...
1
TITLE: Respiratory symptom relief related to reduction in cigarette use.ABSTRACT: Many smokers reduce their cigarette consumption during failed attempts to quit. We report the impact of changes in consumption on smoking-related respiratory symptom severity (SRRSS).Between February 2002 and May 2004 we recruited 383 smo...
1
TITLE: Recurrence of esophageal varices following endoscopic treatment and its impact on rebleeding: comparison of sclerotherapy and ligation.ABSTRACT: Endoscopic variceal ligation is superior to sclerotherapy because of its lower rebleeding and complication rates. However, ligation is not without drawbacks due to a hi...
1
TITLE: The addition of bicalutamide 150 mg to radiotherapy significantly improves overall survival in men with locally advanced prostate cancer.ABSTRACT: Castration therapy adjuvant to radiotherapy can significantly improve overall survival compared with radiotherapy alone in patients with locally advanced prostate can...
1
TITLE: Effect of ramipril on the incidence of diabetes.ABSTRACT: Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension.In a double-blind, randomized clinical trial with a 2-by-2 factorial design, we randomly assigned 5269...