id stringlengths 16 65 | title stringlengths 19 278 | text stringlengths 894 136k | keyphrases listlengths 1 34 | prmu listlengths 1 34 |
|---|---|---|---|---|
Eur_Radiol-2-2-1705545 | Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control
| The aim of this study was to assess the diagnostic accuracy of dual-source computed tomography (DSCT) for evaluation of coronary artery disease (CAD) in a population with extensive coronary calcifications without heart rate control. Thirty patients (24 male, 6 female, mean age 63.1±11.3 years) with a high pre-test prob... | [
"coronary angiography",
"dual-source computed tomography",
"coronary stenosis"
] | [
"P",
"P",
"R"
] |
J_Antimicrob_Chemother-1-1-2386081 | Microbiological evaluation of a new growth-based approach for rapid detection of methicillin-resistant Staphylococcus aureus
| Objectives Recently, a rapid screening tool for methicillin-resistant Staphylococcus aureus (MRSA) has been introduced that applies a novel detection technology allowing the rapid presence or absence of MRSA to be determined from an enrichment broth after only a few hours of incubation. To evaluate the reliability of t... | [
"mrsa",
"infection control",
"spa typing",
"staphylococci"
] | [
"P",
"P",
"P",
"U"
] |
Bioprocess_Biosyst_Eng-2-2-1705473 | On-line optimization of glutamate production based on balanced metabolic control by RQ
| In glutamate fermentations by Corynebacterium glutamicum, higher glutamate concentration could be achieved by constantly controlling dissolved oxygen concentration (DO) at a lower level; however, by-product lactate also severely accumulated. The results of analyzing activities changes of the two key enzymes, glutamate ... | [
"on-line optimization",
"glutamate fermentation",
"metabolic balancing",
"metabolic flux analysis",
"intracellular enzymes activities"
] | [
"P",
"P",
"P",
"P",
"P"
] |
J_Mol_Med-4-1-2374882 | Involvement of (pro)renin receptor in the glomerular filtration barrier
| (Pro)renin receptor-bound prorenin not only causes the generation of angiotensin II via the nonproteolytic activation of prorenin, it also activates the receptor’s own intracellular signaling pathways independent of the generated angiotensin II. Within the kidneys, the (pro)renin receptor is not only present in the glo... | [
"prorenin",
"angiotensin",
"nonproteolytic activation",
"podocytes",
"mitogen-activated protein kinases"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Graefes_Arch_Clin_Exp_Ophthalmol-3-1-2082068 | Ocular blood flow in patients with obstructive sleep apnea syndrome (OSAS)
| Background Sleep-related disorders are among the important risk factors for neurovascular diseases. Obstructive sleep apnea syndrome (OSAS) is characterized by snoring, excessive daytime sleepiness, and insomnia. Our aim was to investigate the presence of glaucoma in patients with OSAS and to reveal vascular pathology ... | [
"ocular blood flow",
"obstructive sleep apnea syndrome",
"glaucoma",
"polysomnography",
"apnea-hypopnea index"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Antonie_Van_Leeuwenhoek-3-1-2140096 | Comparative genomics of Streptomyces avermitilis, Streptomyces cattleya, Streptomyces maritimus and Kitasatospora aureofaciens using a Streptomyces coelicolor microarray system
| DNA/DNA microarray hybridization was used to compare the genome content of Streptomyces avermitilis, Streptomyces cattleya, Streptomyces maritimus and Kitasatospora aureofaciens with that of Streptomyces coelicolor A3(2). The array data showed an about 93% agreement with the genome sequence data available for S. avermi... | [
"actinomycetales",
"genomotyping",
"linear genome"
] | [
"P",
"U",
"R"
] |
Int_J_Colorectal_Dis-4-1-2225995 | Certolizumab pegol, a monthly subcutaneously administered Fc-free anti-TNFα, improves health-related quality of life in patients with moderate to severe Crohn’s disease
| Background and aims Certolizumab pegol, a polyethylene glycolated Fc-free Fab’ was efficacious and well tolerated in patients with moderate-to-severe Crohn’s disease in a previously reported randomized, placebo-controlled study. In this paper, we report the effect of certolizumab pegol on health-related quality of life... | [
"quality of life",
"crohn’s disease",
"inflammatory bowel disease",
"immunotherapy"
] | [
"P",
"P",
"P",
"U"
] |
Virchows_Arch-3-1-1888722 | Search for residual prostate cancer on pT0 radical prostatectomy after positive biopsy
| Reported incidence of no residual prostate cancer (i.e. pathological stage pT0) on radical prostatectomy ranges from 0.07 to 4.2%. The incidence is higher after neoadjuvant endocrine treatment. The aim of this study was to search for residual cancer on radical prostatectomy (RP) specimens when an initial sampling faile... | [
"residual prostate cancer",
"prostate cancer",
"vanishing cancer"
] | [
"P",
"P",
"P"
] |
Breast_Cancer_Res_Treat-3-1-2001222 | Safety of aromatase inhibitors in the adjuvant setting
| The third-generation aromatase inhibitors (AIs) letrozole, anastrozole, and exemestane are replacing tamoxifen as adjuvant therapy in most postmenopausal women with early breast cancer. Although AIs have demonstrated superior efficacy and better overall safety compared with tamoxifen in randomized controlled trials, th... | [
"safety",
"aromatase inhibitors",
"letrozole",
"adjuvant therapy",
"early breast cancer"
] | [
"P",
"P",
"P",
"P",
"P"
] |
J_Gastrointest_Surg-3-1-1852390 | The Extended Learning Curve for Laparoscopic Fundoplication: A Cohort Analysis Of 400 Consecutive Cases
| Many studies have looked at the learning curve associated with laparoscopic Nissen fundoplication (LNF) in a given institution. This study looks at the learning curve of a single surgeon with a large cohort of patients over a 10-year period. Prospective data were collected on 400 patients undergoing laparoscopic fundop... | [
"learning curve",
"laparoscopic nissen fundoplication"
] | [
"P",
"P"
] |
Neuroimage-2-1-2387200 | Abnormal brain connectivity in first-episode psychosis: A diffusion MRI tractography study of the corpus callosum
| A model of disconnectivity involving abnormalities in the cortex and connecting white matter pathways may explain the clinical manifestations of schizophrenia. Recently, diffusion imaging tractography has made it possible to study white matter pathways in detail and we present here a study of patients with first-episod... | [
"first-episode psychosis",
"tractography",
"corpus callosum",
"diffusion tensor imaging",
"dti, diffusion tensor imaging",
"fa, fractional anisotropy",
"mri, magnetic resonance imaging",
"mti, magnetization transfer imaging",
"pdf, probability density function",
"pico, probabilistic index of conne... | [
"P",
"P",
"P",
"P",
"R",
"R",
"M",
"M",
"R",
"R",
"R"
] |
Eur_Radiol-3-1-2077908 | Bone marrow edema-like lesions change in volume in the majority of patients with osteoarthritis; associations with clinical features
| It has been suggested that bone marrow edema-like (BME) lesions in the knee are associated with progression of osteoarthritis (OA). The purpose of our study in patients with OA was to evaluate prospectively changes of BME lesions over 2 years and their relationship with clinical features. Magnetic resonance (MR) images... | [
"oa",
"bme",
"knee",
"womac",
"mri"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Surg_Oncol-4-1-2277451 | Does Practice Make Perfect?
| Extensive literature supports the correlation between surgical volume and improved clinical outcome in the management of various cancers. It is this evidence that has catalysed the creation of centres of excellence. However, on closer inspection, many of these studies are poor quality, low weight and use vastly heterog... | [
"volume",
"outcome",
"cancer"
] | [
"P",
"P",
"P"
] |
Pflugers_Arch-3-1-1915585 | The endothelial glycocalyx: composition, functions, and visualization
| This review aims at presenting state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx. The endothelial glycocalyx is a network of membrane-bound proteoglycans and glycoproteins, covering the endothelium luminally. Both endothelium- and plasma-derived soluble molecules integrate into t... | [
"endothelial glycocalyx",
"heparan sulfate",
"endothelial surface layer",
"hyaluronic acid",
"vascular disease",
"optical imaging",
"two-photon microscopy"
] | [
"P",
"P",
"P",
"P",
"P",
"R",
"R"
] |
Pediatr_Nephrol-3-1-1784542 | Therapeutic approach to FSGS in children
| Therapy of primary focal segmental glomerulosclerosis (FSGS) in children incorporates conservative management and immunosuppression regimens to control proteinuria and preserve kidney function. In long-term cohort studies in adults and children with primary FSGS, renal survival has been directly associated with degree ... | [
"fsgs",
"children",
"proteinuria",
"esrd"
] | [
"P",
"P",
"P",
"P"
] |
Pharm_World_Sci-3-1-2082655 | Understanding the meaning of medications for patients: The medication experience
| Objective: To understand and describe the meaning of medications for patients. Methods: A metasynthesis of three different, yet complementary qualitative research studies, was conducted by two researchers. The first study was a phenomenological study of patients’ medication experiences that used unstructured interviews... | [
"patients",
"medication experience",
"qualitative research",
"pharmaceutical care",
"united states",
"pharmacy services",
"medication management",
"patient-centered care"
] | [
"P",
"P",
"P",
"P",
"P",
"M",
"R",
"M"
] |
Childs_Nerv_Syst-2-2-1705512 | Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray
| Objects Our objective was to develop an oligonucleotide DNA microarray (OMA) for genome-wide microRNA profiling and use this method to find miRNAs, which control organic development especially for nervous system.
Introduction
To date, 326 microRNAs (miRNAs), a ubiquitous family of about 22-nt noncoding regulatory RNAs,... | [
"microrna",
"oligonucleotide microarray",
"expression profile",
"nervous system development"
] | [
"P",
"P",
"P",
"P"
] |
J_Chem_Ecol-4-1-2239250 | Performance of Generalist and Specialist Herbivores and their Endoparasitoids Differs on Cultivated and Wild Brassica Populations
| Through artificial selection, domesticated plants often contain modified levels of primary and secondary metabolites compared to their wild progenitors. It is hypothesized that the changed chemistry of cultivated plants will affect the performance of insects associated with these plants. In this paper, the development ... | [
"diadegma fenestrale",
"plutella xylostella",
"glucosinolates",
"pieris rapae",
"mamestra brassicae",
"diadegma semiclausum",
"direct defense",
"induction",
"crucifer"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"U"
] |
Eur_J_Appl_Physiol-3-1-2039810 | The effect of ambient temperature on gross-efficiency in cycling
| Time-trial performance deteriorates in the heat. This might potentially be the result of a temperature-induced decrease in gross-efficiency (GE). The effect of high ambient temperature on GE during cycling will be studied, with the intent of determining if a heat-induced change in GE could account for the performance d... | [
"performance",
"heat",
"muscle temperature"
] | [
"P",
"P",
"P"
] |
Eur_Radiol-2-2-1766021 | Value of tissue harmonic imaging (THI) and contrast harmonic imaging (CHI) in detection and characterisation of breast tumours
| The purpose of this study was to investigate the extent to which tissue harmonic imaging (THI), speckle reduction imaging (SRI), spatial compounding (SC) and contrast can improve detection and differentiation of breast tumours. We examined 38 patients (14 benign, 24 malignant tumours) with different combinations of THI... | [
"tissue harmonic imaging",
"contrast harmonic imaging",
"spatial compounding",
"breast ultrasound"
] | [
"P",
"P",
"P",
"R"
] |
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