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TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Awakening-free nights percentage improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Pre-dose inspiratory capacity | 0 | {"evidence_spans": [{"end": 20858, "start": 20776, "text": "I = pressurized metered-dose inhaler. No significant differences in pre-dose IC w"}, {"end": 20871, "start": 20776, "text": "I = pressurized metered-dose inhaler. No significant differences in pre-dose IC were observed "}], "id": "338", "pmcid": "3580134", "... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Overall use of daily rescue medication improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Cervical ripening with prostaglandin gel and hygroscopic dilators.
ABSTRACT:
OBJECTIVE: To study the effectiveness and morbidity of adding hygroscopic cervical dilators to prostaglandin gel for cervical ripening and labor induction. STUDY DESIGN: Patients of at least 34 weeks' gestation with a medical indi... | Intervention: Prostaglandin gel plus hygroscopic cervical dilators
Comparator: Prostaglandin gel
Outcome: Infection | 1 | {"evidence_spans": [{"end": 1355, "start": 1242, "text": "). The combined therapy group had a higher infection rate than the prostaglandin-only group (59% vs. 12%, P = 0.0"}, {"end": 1356, "start": 1242, "text": "). The combined therapy group had a higher infection rate than the prostaglandin-only group (59% vs. 12%, P... |
TITLE: The Effect of Clofibrate on Decreasing Serum Bilirubin in Healthy Term Neonates under Home Phototherapy
ABSTRACT.OBJECTIVE:
This study was designed to determine the effect of clofibrate on neonatal uncomplicated jaundice treated with home phototherapy.
ABSTRACT.METHODS:
This clinical trial study was pe... | Intervention: single dose of 50 mg/kg clofibrate
Comparator: control group
Outcome: Total serum bilirubin level | -1 | {"evidence_spans": [{"end": 1122, "start": 1016, "text": " (1.44). The results show that TSB was significantly decreased after 24 and 48 hours in clofibrate group ("}, {"end": 5620, "start": 5504, "text": "t tsb value (Table 1). TBS values show significant difference between the two groups 24 and 48 hours after startin... |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Sepsis related Organ-Failure Assessment (SOFA) baseline scores | 0 | {"evidence_spans": [{"end": 23779, "start": 23608, "text": " presented with at least one MAP measurement below 80 mmHg. There were no differences between groups with respect to the incidence of infections, Sepsis related Organ-Fail"}, {"end": 23856, "start": 23608, "text": " presented with at least one MAP measurement ... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Photo-refractive keratectomy (PRK)
Comparator: Thin-flap laser in situ keratomileusis (LASIK)
Outcome: Higher-order aberrations at 6 months | 0 | {"evidence_spans": [{"end": 13532, "start": 13397, "text": "errations are compared in Figure 2. There were no significant differences between groups in any HOAs throughout the study (P \u2265 0.101), "}, {"end": 13533, "start": 13397, "text": "errations are compared in Figure 2. There were no significant differences be... |
TITLE: Repair of Giant Midline Abdominal Wall Hernias: “Components Separation Technique” versus Prosthetic Repair
ABSTRACT.BACKGROUND:
Reconstruction of giant midline abdominal wall hernias is difficult, and no data are available to decide which technique should be used. It was the aim of this study to compare th... | Intervention: components separation technique (CST)
Comparator: prosthetic repair with e-PTFE patch (PR)
Outcome: Wound complications | 0 | {"evidence_spans": [{"end": 1186, "start": 1093, "text": "rtality. Wound complications were found in 10 of 19 patients after CST and 13 of 18 patients "}], "id": "459", "pmcid": "1913177", "prompt_id": "459", "split_group_id": "1913177", "votes": {"0": 1}} |
TITLE: Randomised phase II evaluation of irinotecan plus high-dose 5-fluorouracil and leucovorin (ILF)
ABSTRACT:
An open-label randomised comparison of efficacy and tolerability of irinotecan plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) (ILF) with etoposide plus 5-FU/LV (ELF) in patients with untreat... | Intervention: Irinotecan with high-dose 5-fluorouracil plus leucovorin (ILF)
Comparator: Etoposide with 5-fluorouracil plus leucovorin (ELF)
Outcome: Clinical response rates at 14 weeks | 0 | {"evidence_spans": [{"end": 915, "start": 727, "text": "s. The objective clinical response rates after 14 weeks treatment (primary end point) were 30% for ILF and 17% for ELF (risk ratio (RR) 0.57, 95% confidence interval (CI) 0.29\u20131.13, P=0.07"}, {"end": 916, "start": 727, "text": "s. The objective clinical respo... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Thin-flap laser in situ keratomileusis (LASIK)
Comparator: Pre-surgery baseline
Outcome: Contrast sensitivity | 0 | {"evidence_spans": [{"end": 11194, "start": 11100, "text": "ime in the study (P \u2265 0.156). The thin-flap LASIK group showed no change in contrast sensitivi"}, {"end": 11348, "start": 11100, "text": "ime in the study (P \u2265 0.156). The thin-flap LASIK group showed no change in contrast sensitivity postoperatively... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Cough score improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: A placebo-controlled double-blind trial
ABSTRACT.BACKGROUND:
The clinical effects of mucolytics in patients with chronic obstructive pulmonary disease (COPD) are discussed controversially. Cineole is the main constituent of eucal... | Intervention: cineole
Comparator: placebo
Outcome: Quality of life | 1 | {"evidence_spans": [{"end": 1659, "start": 1529, "text": "indings. Improvement of lung function, dyspnea and quality of life as multiple criteria were statistically significant relative to"}], "id": "451", "pmcid": "2720945", "prompt_id": "451", "split_group_id": "2720945", "votes": {"1": 1}} |
TITLE: Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated children with Guillain Barré syndrome: a randomized study
ABSTRACT.INTRODUCTION:
Respiratory failure is a life threatening complication of Guillain Barré syndrome (GBS). There is no consensus on the specif... | Intervention: plasma exchange (PE)
Comparator: intravenous immunoglobulin (IVIG)
Outcome: Pediatric Intensive Care Unit (PICU) stay | 0 | {"evidence_spans": [{"end": 1560, "start": 1455, "text": " 0.037. Those in the PE group had a tendency for a shorter Pediatric Intensive Care Unit (PICU) stay (p "}], "id": "465", "pmcid": "3387601", "prompt_id": "465", "split_group_id": "3387601", "votes": {"0": 1}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Pre-dose inspiratory capacity | 0 | {"evidence_spans": [{"end": 20858, "start": 20776, "text": "I = pressurized metered-dose inhaler. No significant differences in pre-dose IC w"}, {"end": 20871, "start": 20776, "text": "I = pressurized metered-dose inhaler. No significant differences in pre-dose IC were observed "}], "id": "337", "pmcid": "3580134", "... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Peak expiratory flow in the morning and evening | 1 | {"evidence_spans": [{"end": 18888, "start": 18782, "text": "ARY FUNCTION.SECONDARY ASSESSMENTS:\r\nMorning and evening PEF improved significantly for all active treatme"}, {"end": 18981, "start": 18782, "text": "ARY FUNCTION.SECONDARY ASSESSMENTS:\r\nMorning and evening PEF improved significantly for all active treatme... |
TITLE: Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial
ABSTRACT.BACKGROUND:
Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there a... | Intervention: progesterone
Comparator: placebo
Outcome: The modified Functional Independence Measure scores | 1 | {"evidence_spans": [{"end": 1981, "start": 1797, "text": "tively). The modified Functional Independence Measure scores in the progesterone group were higher than those in the placebo group at both 3-month and 6-month follow-up (P < 0.05 and P"}, {"end": 1981, "start": 1798, "text": "ively). The modified Functional Inde... |
TITLE: A heart failure self-management program for patients of all literacy levels: A randomized, controlled trial [ISRCTN11535170]
ABSTRACT.BACKGROUND:
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patie... | Intervention: Follow-up and thorough education on self-care
Comparator: Standard information about self-care
Outcome: Baseline systolic dysfunction | 0 | {"evidence_spans": [{"end": 17439, "start": 16964, "text": "all of the remaining participants (93%). At baseline, most characteristics were similar between the two groups (Table 1). However, the control group had more participants with hypertension, fewer with diabetes, and fewer men. Of heart failure related characte... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: 1-hour post-dose inspiratory capacity mean improvements from baseline to the average over the randomized treatment period | 1 | {"evidence_spans": [{"end": 21101, "start": 20872, "text": "mong the treatment groups (figure 5a). Improvements from baseline to the average over the randomized treatment period in 1-hour post-dose IC were significantly greater with both budesonide/formoterol dosages compared with placebo"}, {"end": 21113, "start": 208... |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: Sputum expectoration during a single session | -1 | {"evidence_spans": [{"end": 1371, "start": 1181, "text": "e study. Significantly more sputum was expectorated during a single treatment session and over a 24 h period (mean difference 4.4 g and 6.9 g, respectively) with usual ACTs than with HFCWO ("}, {"end": 1372, "start": 1181, "text": "e study. Significantly more sp... |
TITLE: Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial
ABSTRACT.BACKGROUND:
Laparoscopic surgery has become popular during the last decade, mainly because it is associated with fewer postoperative complications than the conventional open approach. It rem... | Intervention: Laparoscopic surgery
Comparator: Conventional open approach
Outcome: Ulcer mean diameter | 0 | {"evidence_spans": [{"end": 9454, "start": 9340, "text": "Y.RESULTS.INTRAOPERATIVE FINDINGS:\r\nThe discovered ulcer perforations were found to have a mean diameter of 10 mm,"}], "id": "270", "pmcid": "2691927", "prompt_id": "270", "split_group_id": "2691927", "votes": {"0": 1}} |
TITLE: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
ABSTRACT.INTRODUCTION:
Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal.... | Intervention: Thiopental
Comparator: Pentobarbital
Outcome: Refractory intracranial pressure | -1 | {"evidence_spans": [{"end": 1682, "start": 1518, "text": "ication. Uncontrollable intracranial pressure occurred in 11 patients (50%) in the thiopental treatment group and in 18 patients (82%) in the pentobarbital group (P"}], "id": "408", "pmcid": "2575601", "prompt_id": "408", "split_group_id": "2575601", "votes": {"... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Baseline-adjusted average 12-hour FEV1 at end of treatment | 1 | {"evidence_spans": [{"end": 20044, "start": 19826, "text": " in the budesonide/formoterol groups. Mean FEV1 at 12 hours and baseline-adjusted average 12-hour FEV1 were significantly improved with both budesonide/formoterol dosages compared with placebo on the day of randomizati"}, {"end": 20055, "start": 19826, "text":... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Sputum score improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Photo-refractive keratectomy (PRK)
Comparator: Thin-flap laser in situ keratomileusis (LASIK)
Outcome: Uncorrected distance visual acuity at 3 months | 0 | {"evidence_spans": [{"end": 10186, "start": 9848, "text": "RESULTS.VISUAL ACUITY:\r\nTable 2 shows visual acuity outcomes at 1, 3, and 6 months postoperatively. Statistically significant differences were found between PRK and thin-flap LASIK in UDVA at 1 month postoperatively, with thin-flap LASIK eyes showing more imp... |
TITLE: Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]
ABSTRACT.BACKGROUND:
Topical NSAIDs have been proven to relieve the symptoms of osteoarthritis (OA) in short-term studies (2 weeks). To justify its chronic use, efficacy of a t... | Intervention: topical diclofenac solution (Pennsaid®)
Comparator: vehicle control solution (carrier with no diclofenac)
Outcome: Pain on walking | -1 | {"evidence_spans": [{"end": 18105, "start": 17941, "text": ".RESULTS.EFFICACY ANALYSES.A POSTERIORI ANALYSES:\r\nThere was a significantly greater improvement in score with topical diclofenac compared to vehicle control (Table"}], "id": "436", "pmcid": "1201146", "prompt_id": "436", "split_group_id": "1201146", "votes"... |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Average patient's lenght | 0 | {"evidence_spans": [{"end": 9706, "start": 9599, "text": "ncision groups, respectively. Furthermore, no differences were found in the body mass and average length be"}, {"end": 9696, "start": 9612, "text": "s, respectively. Furthermore, no differences were found in the body mass and average"}], "id": "396", "pmcid": "2... |
TITLE: A heart failure self-management program for patients of all literacy levels: A randomized, controlled trial [ISRCTN11535170]
ABSTRACT.BACKGROUND:
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patie... | Intervention: Follow-up and thorough education on self-care
Comparator: Standard information about self-care
Outcome: Baseline angiotensin II receptor blockers (ARBs) intake | 0 | {"evidence_spans": [{"end": 17439, "start": 16964, "text": "all of the remaining participants (93%). At baseline, most characteristics were similar between the two groups (Table 1). However, the control group had more participants with hypertension, fewer with diabetes, and fewer men. Of heart failure related characte... |
TITLE: Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: A Cluster-Randomised Trial in Eastern Zimbabwe
ABSTRACT.BACKGROUND:
HIV-1 control in sub-Saharan Africa requires cost-effective and sustainable programmes that promote behaviour change and reduce cofactor sexually transmi... | Intervention: Communities that received additional education and preventive measures
Comparator: Communities that received standard Government services
Outcome: HIV-1 prevalence | 1 | {"evidence_spans": [{"end": 19723, "start": 19568, "text": " 2.\r\n\r\nBODY.RESULTS.BASELINE DATA:\r\nHIV-1 prevalence was higher in the intervention communities than in the control communities (24% versus 21%, risk ratio"}, {"end": 19725, "start": 19568, "text": " 2.\r\n\r\nBODY.RESULTS.BASELINE DATA:\r\nHIV-1 prevale... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Improvements in St. George's Respiratory Questionnaire overall score | 1 | {"evidence_spans": [{"end": 23598, "start": 23378, "text": " EVALUATIONS.HEALTH STATUS AND COPD SYMPTOMS:\r\nImprovements in SGRQ total score were significantly greater for both budesonide/formoterol dosages compared with placebo (p \u2264 0.006) and for budesonide/formoterol 160/9 \u03bcg c"}, {"end": 23599, "start": ... |
TITLE: A heart failure self-management program for patients of all literacy levels: A randomized, controlled trial [ISRCTN11535170]
ABSTRACT.BACKGROUND:
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patie... | Intervention: Follow-up and thorough education on self-care
Comparator: Standard information about self-care
Outcome: Baseline digoxin intake | 0 | {"evidence_spans": [{"end": 17439, "start": 16964, "text": "all of the remaining participants (93%). At baseline, most characteristics were similar between the two groups (Table 1). However, the control group had more participants with hypertension, fewer with diabetes, and fewer men. Of heart failure related characte... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Baseline-adjusted average 12-hour FEV1 on the day of randomization | 1 | {"evidence_spans": [{"end": 20044, "start": 19826, "text": " in the budesonide/formoterol groups. Mean FEV1 at 12 hours and baseline-adjusted average 12-hour FEV1 were significantly improved with both budesonide/formoterol dosages compared with placebo on the day of randomizati"}, {"end": 20055, "start": 19826, "text":... |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Incisional hernia apparition at follow-up | -1 | {"evidence_spans": [{"end": 1578, "start": 1367, "text": "T.RESULTS:\r\nTwo percent (1/60) of patients that had undergone the procedure through a transverse incision presented with an incisional hernia as opposed to 14% (9/63) of patients from the midline incision group "}], "id": "388", "pmcid": "2690844", "prompt_id"... |
TITLE: Effects of high volume saline enemas vs no enema during labour – The N-Ma Randomised Controlled Trial [ISRCTN43153145]
ABSTRACT.BACKGROUND:
Enemas are used during labour in obstetric settings with the belief that they reduce puerperal and neonatal infections, shorten labour duration, and make delivery clea... | Intervention: 1 litre saline enema
Comparator: no enema
Outcome: Median labour time | 0 | {"evidence_spans": [{"end": 2150, "start": 1752, "text": "r women. We found no significant differences in puerperal or neonatal infection rates (Puerperal infection: 41/190 [22%] with enema v 26/182 [14%] without enema; RR 0.66 CI 95%: 0.43 to 1.03; neonatal infection 38/191 [20%] with enema v 40/179 [22%] without enem... |
TITLE: Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial
ABSTRACT.OBJECTIVES::
To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda.
ABSTRACT.DE... | Intervention: dihydroartemisinin-piperaquine
Comparator: artemether-lumefantrine
Outcome: the risk of recurrent parasitemia due to possible recrudescence | -1 | {"evidence_spans": [{"end": 1491, "start": 1193, "text": "%\u201319%) of follow-up. Similarly, the risk of recurrent parasitemia due to possible recrudescence (adjusted by genotyping) was significantly lower for participants treated with DP than for those treated with AL after 28 d (1.9% versus 8.9%; RD 7.0%, 95% CI 2.... |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Analgesics use | 0 | {"evidence_spans": [{"end": 1916, "start": 1856, "text": "erse group. The use of analgesics did not differ between the"}, {"end": 12362, "start": 12271, "text": " (the remainder) required two or more. No significant difference in the use of analgesics w"}], "id": "394", "pmcid": "2690844", "prompt_id": "394", "split_gr... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Time to discontinuation | 1 | {"evidence_spans": [{"end": 15556, "start": 15440, "text": "n by withdrawal of consent. Time to discontinuation was significantly (p \u2264 0.004) prolonged in both budesonide/formo"}, {"end": 15557, "start": 15440, "text": "n by withdrawal of consent. Time to discontinuation was significantly (p \u2264 0.004) prolonge... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Baseline-adjusted average 12-hour FEV1 on the day of randomization | 1 | {"evidence_spans": [{"end": 20384, "start": 20057, "text": " of treatment (p \u2264 0.002) [table II]. Although both budesonide/formoterol dosages demonstrated significant improvements in mean FEV1 at 12 hours and in baseline-adjusted average 12-hour FEV1 compared with formoterol on the day of randomization (p \u2264 0... |
TITLE: A heart failure self-management program for patients of all literacy levels: A randomized, controlled trial [ISRCTN11535170]
ABSTRACT.BACKGROUND:
Self-management programs for patients with heart failure can reduce hospitalizations and mortality. However, no programs have analyzed their usefulness for patie... | Intervention: Follow-up and thorough education on self-care
Comparator: Standard information about self-care
Outcome: Baseline angiotensin-converting enzyme (ACE) inhibitors intake | 0 | {"evidence_spans": [{"end": 17439, "start": 16964, "text": "all of the remaining participants (93%). At baseline, most characteristics were similar between the two groups (Table 1). However, the control group had more participants with hypertension, fewer with diabetes, and fewer men. Of heart failure related characte... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Photo-refractive keratectomy (PRK)
Comparator: Thin-flap laser in situ keratomileusis (LASIK)
Outcome: Contrast sensitivity | 0 | {"evidence_spans": [{"end": 1470, "start": 1323, "text": " 0.600). Significant differences were not found between treatment groups in contrast sensitivity (P \u2265 0.156) or CDVA (P = 0.800) at postoperative 6"}, {"end": 11099, "start": 10895, "text": "ESULTS.CONTRAST SENSITIVITY:\r\nContrast sensitivity measurements ... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Improvements in St. George's Respiratory Questionnaire overall score | 1 | {"evidence_spans": [{"end": 23598, "start": 23378, "text": " EVALUATIONS.HEALTH STATUS AND COPD SYMPTOMS:\r\nImprovements in SGRQ total score were significantly greater for both budesonide/formoterol dosages compared with placebo (p \u2264 0.006) and for budesonide/formoterol 160/9 \u03bcg c"}, {"end": 23599, "start": ... |
TITLE: Cervical ripening with prostaglandin gel and hygroscopic dilators.
ABSTRACT:
OBJECTIVE: To study the effectiveness and morbidity of adding hygroscopic cervical dilators to prostaglandin gel for cervical ripening and labor induction. STUDY DESIGN: Patients of at least 34 weeks' gestation with a medical indi... | Intervention: Prostaglandin gel plus hygroscopic cervical dilators
Comparator: Prostaglandin gel
Outcome: Baseline demographic differences | 0 | {"evidence_spans": [{"end": 1048, "start": 989, "text": "ors. No demographic differences were noted between the grou"}, {"end": 1048, "start": 991, "text": "s. No demographic differences were noted between the grou"}], "id": "418", "pmcid": "1784771", "prompt_id": "418", "split_group_id": "1784771", "votes": {"0": 2}} |
TITLE: Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: A placebo-controlled double-blind trial
ABSTRACT.BACKGROUND:
The clinical effects of mucolytics in patients with chronic obstructive pulmonary disease (COPD) are discussed controversially. Cineole is the main constituent of eucal... | Intervention: cineole
Comparator: placebo
Outcome: Trouble in breathing, dyspnea in the morning and dyspnea at rest | -1 | {"evidence_spans": [], "id": "453", "pmcid": "2720945", "prompt_id": "453", "split_group_id": "2720945", "votes": {"-1": 1}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Peak expiratory flow in the morning and evening | 1 | {"evidence_spans": [{"end": 18968, "start": 18782, "text": "ARY FUNCTION.SECONDARY ASSESSMENTS:\r\nMorning and evening PEF improved significantly for all active treatments compared with placebo (p \u2264 0.012) and for both budesonide/formoterol dosages"}, {"end": 18981, "start": 18782, "text": "ARY FUNCTION.SECONDARY ... |
TITLE: Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: A Cluster-Randomised Trial in Eastern Zimbabwe
ABSTRACT.BACKGROUND:
HIV-1 control in sub-Saharan Africa requires cost-effective and sustainable programmes that promote behaviour change and reduce cofactor sexually transmi... | Intervention: Baseline communities that received additional education and preventive measures
Comparator: Baseline communities that received standard Government services
Outcome: High-risk sexual behaviour | 0 | {"evidence_spans": [{"end": 1230, "start": 1094, "text": "ties. No evidence was found for reduced incidence of self-reported STI symptoms or high-risk sexual behaviour in the intervention commun"}], "id": "262", "pmcid": "1831737", "prompt_id": "262", "split_group_id": "1831737", "votes": {"0": 2}} |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: 24-hour urinary cortisol at end of treatment | -1 | {"evidence_spans": [{"end": 30616, "start": 30139, "text": "ECGs, QT interval and Holter assessments were rare. The geometric mean values of 24-hour urinary cortisol at 6 months and end of treatment were lower in both budesonide/formoterol dosage groups compared with formoterol and placebo (see table SV in the suppleme... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Amount of exacerbations per patient-treatment year | -1 | {"evidence_spans": [{"end": 22351, "start": 22033, "text": "ed with formoterol (p = 0.026) [figure 6]. In addition, significant reductions in the overall number of exacerbations per patient-treatment year were observed with budesonide/formoterol 320/9 \u03bcg and 160/9 \u03bcg versus placebo (37% and 41%, respectively;... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Pre-dose FEV1 improvement | 1 | {"evidence_spans": [{"end": 17776, "start": 17538, "text": "UNCTION.CO-PRIMARY ASSESSMENTS:\r\nImprovements in pre-dose FEV1 were significantly greater for budesonide/formoterol 320/9 \u03bcg compared with formoterol (primary comparison; p = 0.008) and for both budesonide/formoterol dosages compared with"}, {"end": 177... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Overall use of daily rescue medication improvement | 1 | {"evidence_spans": [{"end": 24409, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial
ABSTRACT.BACKGROUND:
Laparoscopic surgery has become popular during the last decade, mainly because it is associated with fewer postoperative complications than the conventional open approach. It rem... | Intervention: Laparoscopic surgery
Comparator: Conventional open approach
Outcome: Postoperative complications | 0 | {"evidence_spans": [{"end": 1401, "start": 1362, "text": "c group. Complications were equally dis"}], "id": "267", "pmcid": "2691927", "prompt_id": "267", "split_group_id": "2691927", "votes": {"0": 2}} |
TITLE: Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis
ABSTRACT.BACKGROUND:
High frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK... | Intervention: High frequency chest wall oscillation
Comparator: Usual airway clearance techniques
Outcome: Visual analogue scale scores for urinary leakage | 0 | {"evidence_spans": [{"end": 16688, "start": 16574, "text": "sual ACT compared with HFCWO are shown in table 4. No significant differences were observed in VAS scores for comf"}], "id": "249", "pmcid": "2922723", "prompt_id": "249", "split_group_id": "2922723", "votes": {"0": 2}} |
TITLE: Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial
ABSTRACT.BACKGROUND:
Laparoscopic surgery has become popular during the last decade, mainly because it is associated with fewer postoperative complications than the conventional open approach. It rem... | Intervention: Laparoscopic surgery
Comparator: Conventional open approach
Outcome: Median loss of blood | 0 | {"evidence_spans": [{"end": 9878, "start": 9830, "text": "onsensus on how much was necessary. Median blood"}], "id": "272", "pmcid": "2691927", "prompt_id": "272", "split_group_id": "2691927", "votes": {"0": 2}} |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Hospital stay | 0 | {"evidence_spans": [{"end": 14120, "start": 14026, "text": " group left hospital care on day 8 or later. The duration of hospital admission did not differ"}, {"end": 14121, "start": 14026, "text": " group left hospital care on day 8 or later. The duration of hospital admission did not differ "}], "id": "404", "pmcid": ... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Peak expiratory flow in the morning and evening | 1 | {"evidence_spans": [{"end": 18968, "start": 18782, "text": "ARY FUNCTION.SECONDARY ASSESSMENTS:\r\nMorning and evening PEF improved significantly for all active treatments compared with placebo (p \u2264 0.012) and for both budesonide/formoterol dosages"}, {"end": 18981, "start": 18782, "text": "ARY FUNCTION.SECONDARY ... |
TITLE: An Open Label, Randomised Trial of Artesunate+Amodiaquine, Artesunate+Chlorproguanil-Dapsone and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria
ABSTRACT.BACKGROUND:
Artesunate+amodiaquine (AS+AQ) and artemether-lumefantrine (AL) are now the most frequently recommended first line treatme... | Intervention: Artesunate+amodiaquine (AS+AQ)
Comparator: artemether-lumefantrine (AL) and and Artesunate+chlorproguanil-dapsone (AS+CD)
Outcome: the parasitological and clinical failure rate at day 28 post treatment | 0 | {"evidence_spans": [{"end": 1357, "start": 1073, "text": "nalysis, the parasitological and clinical failure rate at day 28 post treatment (PCF28) was lower in the AS+AQ group compared to the AL or AS+CD groups (corrected for re-infections: 6.6% vs 13.8% and 13.8% respectively, p = 0.08; uncorrected: 14.6% vs 27.6% and ... |
TITLE: Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial
ABSTRACT.BACKGROUND:
To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules.
ABSTRACT.METHO... | Intervention: receive a dose of 0.25 mg (1:1:1 ratio) and then allocated to active treatment (CCH)
Comparator: dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated placebo (4:1 ratio)
Outcome: percentage changes in area | 0 | {"evidence_spans": [{"end": 1392, "start": 1172, "text": "n = 74), percentage changes in area were significantly greater with CCH 0.40 mg (\u221280.1%, P = 0.0002) and CCH 0.60 mg (\u221278.2%, P = 0.0003), but not CCH 0.25 mg (\u221258.3%, P = 0.079), versus placebo (\u221242.2%) at post-treatmen"}], "id": "611", "pmc... |
TITLE: The effect of uphill stride manipulation on race walking gait
ABSTRACT:
Stride length analysis represents an easy method for assessing race walking kinematics. However, the stride parameters emerging from such an analysis have never been used to design a training protocol aimed at increasing stride length.... | Intervention: stride frequency manipulation
Comparator: free stride frequency
Outcome: internal work | -1 | {"evidence_spans": [{"end": 908, "start": 647, "text": "s. Kinematic parameters measured before and after the 3-week training in RWM showed increased stride length (4.54%; p<0.0001) and contact time (4.58%; p<0.001); inversely, a decreased stride frequency (4.44%; p<0.0001) and internal work (7.09%; p<0.05) were fou"},... |
TITLE: The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome: A randomized placebo-controlled trial
ABSTRACT.BACKGROUND::
Evidence has shown beneficial effects of probiotics in the treatment of irritable bowel syndrome (IBS); however, there is sti... | Intervention: receive a probiotic compound containing seven bacteria species including Lactobacillus strains, Bifidobacterium strains and Streptococcus thermophiles
Comparator: similar placebo, twice daily after a meal for 14 consecutive days
Outcome: Improvement in bowel habit | 0 | {"evidence_spans": [{"end": 1394, "start": 1285, "text": "P>0.05). Improvement in bowel habit was observed in 33.3% of the probiotic and 36.5% of the placebo group (P "}, {"end": 1394, "start": 1286, "text": ">0.05). Improvement in bowel habit was observed in 33.3% of the probiotic and 36.5% of the placebo group (P "}]... |
TITLE: Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial
ABSTRACT.BACKGROUND:
To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules.
ABSTRACT.METHO... | Intervention: receive a dose of 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated to active treatment (CCH)
Comparator: dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated placebo (4:1 ratio)
Outcome: percentage changes in area | 1 | {"evidence_spans": [{"end": 1392, "start": 1172, "text": "n = 74), percentage changes in area were significantly greater with CCH 0.40 mg (\u221280.1%, P = 0.0002) and CCH 0.60 mg (\u221278.2%, P = 0.0003), but not CCH 0.25 mg (\u221258.3%, P = 0.079), versus placebo (\u221242.2%) at post-treatmen"}], "id": "608", "pmc... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Full return to normal work/employment | 1 | {"evidence_spans": [], "id": "595", "pmcid": "4819709", "prompt_id": "595", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Wearing clothes that show the legs | 0 | {"evidence_spans": [], "id": "593", "pmcid": "4819709", "prompt_id": "593", "split_group_id": "4819709", "votes": {"0": 2}} |
TITLE: Physiological-dose steroid therapy in sepsis [ISRCTN36253388]
ABSTRACT.INTRODUCTION:
The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortality in patie... | Intervention: received standard therapy for sepsis and physiological-dose steroid therapy for 10 days;
Comparator: received only standard therapy for sepsis
Outcome: The median stay in hospital | 0 | {"evidence_spans": [{"end": 18447, "start": 18282, "text": "in all patients was attributed to sepsis. The median stay in hospital was 14 days (95% CI 11.09\u201320.08) in the steroid therapy group and 13 days (95% CI 10.13\u201316.37) "}], "id": "551", "pmcid": "125315", "prompt_id": "551", "split_group_id": "125315", ... |
TITLE: Lay support for pregnant women with social risk: a randomised controlled trial
ABSTRACT.OBJECTIVES:
We sought evidence of effectiveness of lay support to improve maternal and child outcomes in disadvantaged families.
ABSTRACT.DESIGN:
Prospective, pragmatic, individually randomised controlled trial.
... | Intervention: additional lay support (in this instance Pregnancy Outreach Workers, POWs)
Comparator: standard maternity care
Outcome: Postnatal depression (Edinburgh Postnatal Depression Scale17 EPDS) | 0 | {"evidence_spans": [{"end": 20219, "start": 20086, "text": "ean EPDS (MD \u22120.79 (95% CI \u22121.56 to \u22120.02) p=0.05), although no significant differences were seen in the mean EPDS (mean difference ("}], "id": "556", "pmcid": "4785315", "prompt_id": "556", "split_group_id": "4785315", "votes": {"0": 1}} |
TITLE: A randomized trial of artemether-lumefantrine
ABSTRACT.BACKGROUND:
The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum. The fixed combination of oral artemether-lumefantrine, an artemisinin combination therapy (ACT) is ... | Intervention: Artemether-lumefantrine
Comparator: Mefloquine-artesunate
Outcome: Decrease in haematocrit level at day 7 | -1 | {"evidence_spans": [{"end": 13337, "start": 13195, "text": "group and 13.8% in MAS3 group (P = 0.33). The mean (SD) decrease in haematocrit value at day seven from baseline was greater in the group rece"}, {"end": 13444, "start": 13338, "text": "ving MAS3 than in the ALN group: 9.3% (SD,11.5%; 95% CI, 7.7% to 10.9%) co... |
TITLE: The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome: A randomized placebo-controlled trial
ABSTRACT.BACKGROUND::
Evidence has shown beneficial effects of probiotics in the treatment of irritable bowel syndrome (IBS); however, there is sti... | Intervention: receive a probiotic compound containing seven bacteria species including Lactobacillus strains, Bifidobacterium strains and Streptococcus thermophiles
Comparator: similar placebo, twice daily after a meal for 14 consecutive days
Outcome: quality-of-life | 0 | {"evidence_spans": [{"end": 10485, "start": 10271, "text": "he placebo group (P = 0.910). With regard to QOL, an improvement was observed in the probiotic (P = 0.008), but not in the placebo group (P = 0.175); though, there was no significant difference between the two grou"}, {"end": 10494, "start": 10271, "text": "he... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Bending the legs without discomfort | 1 | {"evidence_spans": [{"end": 12960, "start": 12797, "text": "ULTRASOUND\u2010GUIDED FOAM SCLEROTHERAPY :\r\nParticipants randomized to UGFS recalled being able to carry out 13 of the 15 behaviours significantly more quickly than th"}], "id": "583", "pmcid": "4819709", "prompt_id": "583", "split_group_id": "4819709", "vo... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Endovenous laser ablation
Comparator: Ultrasound‐guided foam sclerotherapy
Outcome: walking short distances without discomfort, walking long distances, looking after children, full return to normal work/employment | -1 | {"evidence_spans": [{"end": 17579, "start": 17375, "text": "mized to EVLA and those randomized to UGFS (Table \r\n4). Return to 'walking short distances without discomfort', 'walking long distances', 'looking after children' and 'full return to normal work/employme"}], "id": "599", "pmcid": "4819709", "prompt_id": "59... |
TITLE: OA01.06. A clinical evaluation of langlimool (gloriosa superba) on inderlupta w.s.r. to alopacia areata
ABSTRACT.PURPOSE::
Beauty has very important role in our life. Hair plays very vital role in our beauty. A human body without hair would be seen just as a tree without leaves. So everyone has an ambition... | Intervention: Gomutra sodhit Langali moola with honey for external application
Comparator: Godugdha sodhit Langali moola with honey for external application
Outcome: Indralupta is a unique, idiopathic, non-cictricial, non-inflammatory alopecia, presents as discoid areas of hair loss. | -1 | {"evidence_spans": [{"end": 1828, "start": 1358, "text": "SULT ::\r\nIt was observed that after 60 days of treatment with Gomutrashodhit Langlimool in Group A there was reduction in Hair fall which is statistically highly significant (P<0.001) and highly significant improvement was observed in reducing dandruff.(p<0.00... |
TITLE: Effects of lifestyle physical activity on perceived symptoms and physical function in adults with fibromyalgia: results of a randomized trial
ABSTRACT.INTRODUCTION:
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated... | Intervention: lifestyle physical activity (LPA) - 30 minutes of self-selected moderate-intensity LPA, five to seven days per week
Comparator: fibromyalgia (FM) education control (FME) group - received information and support
Outcome: pain | -1 | {"evidence_spans": [{"end": 20896, "start": 20721, "text": "er points, BMI, and six-minute walk distance (see Table 3). At post-testing, compared to the FME group, the LPA group reported significant reductions in the FIQ score (P = .03"}], "id": "560", "pmcid": "2888205", "prompt_id": "560", "split_group_id": "2888205"... |
TITLE: Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial
ABSTRACT.SUMMARY.BACKGROUND:
Identification of new ways to increase access to antiretroviral therapy in Africa is an urgent priority. We... | Intervention: Home-based HIV-care strategy
Comparator: Facility-based HIV-care strategy
Outcome: Virological failure | 0 | {"evidence_spans": [{"end": 21892, "start": 21764, "text": "on and survival over time by study group. Rates of detection of plasma viral loads of more than 500 copies per mL after a 6-mont"}], "id": "485", "pmcid": "2806484", "prompt_id": "485", "split_group_id": "2806484", "votes": {"0": 1}} |
TITLE: Effects of lifestyle physical activity on perceived symptoms and physical function in adults with fibromyalgia: results of a randomized trial
ABSTRACT.INTRODUCTION:
Although exercise is therapeutic for adults with fibromyalgia (FM), its symptoms often create obstacles that discourage exercise. We evaluated... | Intervention: lifestyle physical activity (LPA) - 30 minutes of self-selected moderate-intensity LPA, five to seven days per week
Comparator: fibromyalgia (FM) education control (FME) group - received information and support
Outcome: six-minute walk test | 0 | {"evidence_spans": [{"end": 1230, "start": 1146, "text": "= .006). There were no differences between the groups on the six-minute walk test (P"}], "id": "561", "pmcid": "2888205", "prompt_id": "561", "split_group_id": "2888205", "votes": {"0": 1}} |
TITLE: A Randomized Controlled Trial Investigating the Effects of a Low–Glycemic Index Diet on Pregnancy Outcomes in Gestational Diabetes Mellitus
ABSTRACT.OBJECTIVE:
The prevalence of gestational diabetes mellitus (GDM) is rising. There is little evidence to demonstrate the effectiveness of one dietary therapy o... | Intervention: low–glycemic index diet (target glycemic index [GI] ~50)
Comparator: high-fiber moderate-GI diet (HF) (target glycemic index GI ~60)
Outcome: low–glycemic index | -1 | {"evidence_spans": [{"end": 1053, "start": 950, "text": "ESULTS:\r\nThe LGI group achieved a modestly lower GI than the HF group (mean \u00b1 SEM 47 \u00b1 1 vs. 53 \u00b1 1; P "}], "id": "534", "pmcid": "3198285", "prompt_id": "534", "split_group_id": "3198285", "votes": {"-1": 2}} |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Having a bath or shower | 0 | {"evidence_spans": [], "id": "589", "pmcid": "4819709", "prompt_id": "589", "split_group_id": "4819709", "votes": {"0": 2}} |
TITLE: A randomized comparison between three types of irrigating fluids during transurethral resection in benign prostatic hyperplasia
ABSTRACT.BACKGROUND:
Central nervous system changes, circulatory and electrolyte imbalances are the main complications of endoscopic transurethral resection of the prostate (TURP)... | Intervention: glycine 1.5% solution as irrigating fluid
Comparator: glucose 5% solution
Outcome: transurethral resection (TUR) syndrome | 1 | {"evidence_spans": [{"end": 16772, "start": 16751, "text": "(n = 120) Saline grou"}], "id": "601", "pmcid": "2891743", "prompt_id": "601", "split_group_id": "2891743", "votes": {"1": 1}} |
TITLE: Improvements in survival of the uncemented Nottingham Total Shoulder prosthesis: a prospective comparative study
ABSTRACT.BACKGROUND:
The uncemented Nottingham Total Shoulder Replacement prosthesis system (Nottingham TSR) was developed from the previous BioModular® shoulder prosthesis taking into considera... | Intervention: Initial Nottingham TSR design prosthesis
Comparator: BioModular® shoulder prosthesis
Outcome: 8-year survivorship in patients with osteoarthritis | 1 | {"evidence_spans": [{"end": 20733, "start": 20389, "text": "fidence intervals). The initial Nottingham TSR prostheses showed higher eight year survivorship than BioModular\u00ae prostheses in patients with OA (p < 0.01). Survivorship of the BioModular\u00ae prosthesis in patients with primary osteoarthritis was 70.9% ... |
TITLE: A randomized comparison between three types of irrigating fluids during transurethral resection in benign prostatic hyperplasia
ABSTRACT.BACKGROUND:
Central nervous system changes, circulatory and electrolyte imbalances are the main complications of endoscopic transurethral resection of the prostate (TURP)... | Intervention: glycine 1.5% solution as irrigating fluid
Comparator: normal saline 0.9% solution
Outcome: transurethral resection (TUR) syndrome | 1 | {"evidence_spans": [{"end": 16771, "start": 16751, "text": "(n = 120) Saline gro"}], "id": "602", "pmcid": "2891743", "prompt_id": "602", "split_group_id": "2891743", "votes": {"1": 1}} |
TITLE: Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia
ABSTRACT.BACKGROUND/AIMS:
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 1... | Intervention: Rosuvastatin
Comparator: Atorvastatin
Outcome: Levels of LDL cholesterol after 6 weeks of treatment | -1 | {"evidence_spans": [{"end": 1202, "start": 783, "text": "ESULTS:\r\nAfter 6 weeks of treatment, greater reductions in total cholesterol (- 35.94 \u00b1 11.38 vs. - 30.07 \u00b1 10.46%, p < 0.001), LDL-C (48.04 \u00b1 14.45 vs. 39.52 \u00b1 14.42%, p < 0.001), non-high-density lipoprotein cholesterol (- 42.93 \u00b1 13.... |
TITLE: Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial
ABSTRACT.BACKGROUND:
To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules.
ABSTRACT.METHO... | Intervention: receive a dose of 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated to active treatment (CCH)
Comparator: dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated placebo (4:1 ratio)
Outcome: global assessment of improvement | 1 | {"evidence_spans": [{"end": 1656, "start": 1544, "text": "Week 8, investigator global assessment of improvement was significantly greater with CCH 0.40 mg and 0.60 mg (P "}], "id": "610", "pmcid": "5577662", "prompt_id": "610", "split_group_id": "5577662", "votes": {"1": 1}} |
TITLE: A randomized trial of artemether-lumefantrine
ABSTRACT.BACKGROUND:
The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum. The fixed combination of oral artemether-lumefantrine, an artemisinin combination therapy (ACT) is ... | Intervention: Artemether-lumefantrine
Comparator: Mefloquine-artesunate
Outcome: P. vivax parasitaemia diagnosed during follow up | 1 | {"evidence_spans": [{"end": 14942, "start": 14730, "text": "ODY.RESULTS.OTHER PARASITOLOGICAL FINDINGS:\r\nOf 452 patients, 119 (26.3%) had P. vivax parasitaemia detected during follow up. There were significantly fewer cases of vivax malaria in the MAS3 group (29 of 227) t"}, {"end": 14942, "start": 14812, "text": "iv... |
TITLE: Abdominal Wound Problems After Hysterectomy With
Electrocautery vs. Scalpel Subcutaneous Incision
ABSTRACT:
The purpose of this study was to evaluate the relationship between postoperative abdominal incision
problems and opening subcutaneous tissues with electrocautery or scalpel. Women scheduled for
el... | Intervention: opening subcutaneous tissues with electrocautery
Comparator: opening subcutaneous tissues with scalpel
Outcome: wound problem | 0 | {"evidence_spans": [{"end": 735, "start": 601, "text": "iology.\r\nFifteen of 380 women (3.9%) developed a wound problem; six had scalpel and nine had\r\nelectrosurgical subcutaneous incisions ("}], "id": "531", "pmcid": "2364680", "prompt_id": "531", "split_group_id": "2364680", "votes": {"0": 2}} |
TITLE: Interferon-gamma in the first-line therapy of ovarian cancer: a randomized phase III trial
ABSTRACT:
Intraperitoneal treatment with interferon-γ (IFN-γ) has been shown to achieve surgically documented responses in the second-line therapy of ovarian cancer. To assess its efficacy in the first-line therapy, ... | Intervention: Cisplatin and Cyclophosphamide, plus subcutaneous IFN-γ
Comparator: Cisplatin and Cyclophosphamide
Outcome: Overall survival at 3 years | 0 | {"evidence_spans": [{"end": 1003, "start": 916, "text": "). Three-year overall survival was 58% and 74% accordingly (n.s., median not yet reache"}], "id": "491", "pmcid": "2363351", "prompt_id": "491", "split_group_id": "2363351", "votes": {"0": 2}} |
TITLE: A Randomized Controlled Trial Investigating the Effects of a Low–Glycemic Index Diet on Pregnancy Outcomes in Gestational Diabetes Mellitus
ABSTRACT.OBJECTIVE:
The prevalence of gestational diabetes mellitus (GDM) is rising. There is little evidence to demonstrate the effectiveness of one dietary therapy o... | Intervention: low–glycemic index diet (target glycemic index [GI] ~50)
Comparator: high-fiber moderate-GI diet (HF) (target glycemic index GI ~60)
Outcome: Birth weight (kg), Birth weight centile, Small for gestational age, Macrosomia, Infant head circumference, Infant length (cm), Ponderal index (kg/m3), Maternal weig... | 0 | {"evidence_spans": [], "id": "536", "pmcid": "3198285", "prompt_id": "536", "split_group_id": "3198285", "votes": {"0": 1}} |
TITLE: Double-Blind Placebo-Controlled Treatment Trial of
ABSTRACT:
Objective: The purpose of this study was to determine if treatment of pregnant women with Chlamydia trachomatis infection would lower the incidence of preterm delivery and/or low birth weight.
Methods: Pregnant women between the 2... | Intervention: Erythromycin
Comparator: Placebo
Outcome: Preterm delivery | 0 | {"evidence_spans": [{"end": 734, "start": 549, "text": "esults: When the results were examined without regard to study site, erythromycin had little impact on reducing low birth weight (8% vs. 11%, P = 0.4) or preterm delivery (13% vs. 15%, "}, {"end": 735, "start": 549, "text": "esults: When the results were examined ... |
TITLE: Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial
ABSTRACT.SUMMARY.BACKGROUND:
Identification of new ways to increase access to antiretroviral therapy in Africa is an urgent priority. We... | Intervention: Home-based HIV-care strategy
Comparator: Facility-based HIV-care strategy
Outcome: Costs for the health service | 0 | {"evidence_spans": [{"end": 26722, "start": 26512, "text": "5. Results were similar for other endpoints. The home-based strategy did not result in higher costs for the health service. Moreover, home-based care was slightly cheaper than facility-based care by about $45 p"}], "id": "487", "pmcid": "2806484", "prompt_id":... |
TITLE: Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial
ABSTRACT.BACKGROUND:
To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules.
ABSTRACT.METHO... | Intervention: receive a dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated to active treatment (CCH)
Comparator: dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated placebo (4:1 ratio)
Outcome: Mean change in nodular consistency and hardness | 1 | {"evidence_spans": [{"end": 1531, "start": 1393, "text": " Week 8. Mean change in nodular consistency and hardness were significantly improved with CCH versus placebo at Weeks 4 and 8 (P \u2264 0.0139 "}, {"end": 1532, "start": 1393, "text": " Week 8. Mean change in nodular consistency and hardness were significantly i... |
TITLE: Behavioural recovery after treatment for varicose veins
ABSTRACT.BACKGROUND:
The aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (... | Intervention: Ultrasound‐guided foam sclerotherapy
Comparator: surgery
Outcome: Doing housework | 1 | {"evidence_spans": [], "id": "591", "pmcid": "4819709", "prompt_id": "591", "split_group_id": "4819709", "votes": {"1": 1}} |
TITLE: Antibiotic Prophylaxis Using Third Generation Cephalosporins Can Reduce the Risk of Early Rebleeding in the First Acute Gastroesophageal Variceal Hemorrhage: A Prospective Randomized Study
ABSTRACT:
Bacterial infection may be a critical trigger for variceal bleeding. Antibiotic prophylaxis can prevent rebl... | Intervention: received antibiotics treatment after randomization with intravenous cefotaxime 2 gram q 8 hr for 7 days
Comparator: received antibiotics only when infection was suspected or established
Outcome: rebleeding | -1 | {"evidence_spans": [{"end": 1165, "start": 1026, "text": "). The actuarial rebleeding rate in the prophylactic group was significantly lower than that in the ondemand group (33.9% vs. 62.1%, p=0.00"}, {"end": 14406, "start": 14262, "text": " data is outlined in Table 3. The rebleeding rate in the prophylactic group was... |
TITLE: Fibrin Glue Reduces the Duration of Lymphatic Drainage after Lumpectomy and Level II or III Axillary Lymph Node Dissection for Breast Cancer: A Prospective Randomized Trial
ABSTRACT:
This randomized prospective study investigated the effect of fibrin glue use on drainage duration and overall drain output a... | Intervention: fibrin glue group (glue sprayed onto the axillary dissection site)
Comparator: control group
Outcome: The mean drainage duration | 0 | {"evidence_spans": [{"end": 804, "start": 670, "text": "a. Overall, the fibrin glue and control groups were similar in terms of drainage duration, overall drain output, and incidence of sero"}, {"end": 9096, "start": 8985, "text": "DRAIN OUTPUT AND COMPLICATIONS:\r\nThe mean drainage duration was 3.3 days for the fibri... |
TITLE: A Theory-Based Video Messaging Mobile Phone Intervention for Smoking Cessation: Randomized Controlled Trial
ABSTRACT.BACKGROUND:
Advances in technology allowed the development of a novel smoking cessation program delivered by video messages sent to mobile phones. This social cognitive theory-based interve... | Intervention: an automated package of video and text messages over 6 months that was tailored to self-selected quit date, role model, and timing of messages. Extra messages were available on demand to beat cravings and address lapses.
Comparator: set a quit date and received a general health video message sent to their... | 0 | {"evidence_spans": [{"end": 19209, "start": 18892, "text": " of these points (data not shown). At 6 months all participants were asked how many quit attempts they had made during the study period. In the intervention group 7/73 respondents (9.6%) and in the control group 4/81 (4.9%) (P = .3) stated they did not attem... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Pre-dose FEV1 improvement | 1 | {"evidence_spans": [{"end": 17776, "start": 17538, "text": "UNCTION.CO-PRIMARY ASSESSMENTS:\r\nImprovements in pre-dose FEV1 were significantly greater for budesonide/formoterol 320/9 \u03bcg compared with formoterol (primary comparison; p = 0.008) and for both budesonide/formoterol dosages compared with"}], "id": "314... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Baseline-adjusted average 12-hour FEV1 on the day of randomization | 1 | {"evidence_spans": [{"end": 20045, "start": 19826, "text": " in the budesonide/formoterol groups. Mean FEV1 at 12 hours and baseline-adjusted average 12-hour FEV1 were significantly improved with both budesonide/formoterol dosages compared with placebo on the day of randomizatio"}, {"end": 20391, "start": 20057, "text"... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Mean FEV1 at 12 hours at end of treatment | 1 | {"evidence_spans": [{"end": 20373, "start": 20057, "text": " of treatment (p \u2264 0.002) [table II]. Although both budesonide/formoterol dosages demonstrated significant improvements in mean FEV1 at 12 hours and in baseline-adjusted average 12-hour FEV1 compared with formoterol on the day of randomization (p \u2264 0... |
TITLE: Incisional hernia after upper abdominal surgery: a randomised controlled trial of midline versus transverse incision
ABSTRACT.OBJECTIVES:
To determine whether a transverse incision is an alternative to a midline incision in terms of incisional hernia incidence, surgical site infection, postoperative pain, ... | Intervention: Transverse incision
Comparator: Midline incision
Outcome: Better cosmetic appearance of the incision as subjectively assessed by surgeons | 1 | {"evidence_spans": [{"end": 15948, "start": 15787, "text": "ing the postoperative follow-up outpatient clinic visit. Both the surgeons and the patients found the scar resulting from the transverse incision to be more cosm"}, {"end": 15958, "start": 15787, "text": "ing the postoperative follow-up outpatient clinic visit... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Awakening-free nights percentage improvement | 1 | {"evidence_spans": [{"end": 24054, "start": 23757, "text": "l versus placebo (i.e. decrease of \u22654 points). Significantly greater improvements in COPD symptom variables were observed for both budesonide/formoterol dosages versus placebo for all variables (BCSS, dyspnoea score, cough score, sputum score, sleep score... |
TITLE: Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial [ISRCTN20244858]
ABSTRACT.BACKGROUND:
Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and defi... | Intervention: Exercise
Comparator: No exercise
Outcome: SF-36 Mental Component Summary scale at 6 weeks | 1 | {"evidence_spans": [{"end": 15870, "start": 15685, "text": "TWEEN-GROUP DIFFERENCES.SECONDARY OUTCOMES:\r\nA significant improvement was found in the exercise group compared to the control group at six weeks with regard to the SF-36 Mental Compone"}], "id": "425", "pmcid": "1187893", "prompt_id": "425", "split_group_id... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Placebo
Outcome: Amount of exacerbations per patient-treatment year | -1 | {"evidence_spans": [{"end": 22252, "start": 22046, "text": "terol (p = 0.026) [figure 6]. In addition, significant reductions in the overall number of exacerbations per patient-treatment year were observed with budesonide/formoterol 320/9 \u03bcg and 160/9 \u03bcg versus plac"}, {"end": 22305, "start": 22046, "text": "... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 320/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Mean FEV1 at 12 hours on the day of randomization | 1 | {"evidence_spans": [{"end": 20045, "start": 19826, "text": " in the budesonide/formoterol groups. Mean FEV1 at 12 hours and baseline-adjusted average 12-hour FEV1 were significantly improved with both budesonide/formoterol dosages compared with placebo on the day of randomizatio"}, {"end": 20391, "start": 20057, "text"... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Formoterol DPI 9 μg
Outcome: Mean FEV1 at 12 hours on the day of randomization | 1 | {"evidence_spans": [{"end": 20391, "start": 20057, "text": " of treatment (p \u2264 0.002) [table II]. Although both budesonide/formoterol dosages demonstrated significant improvements in mean FEV1 at 12 hours and in baseline-adjusted average 12-hour FEV1 compared with formoterol on the day of randomization (p \u2264 0... |
TITLE: A prospective, contralateral comparison of photorefractive keratectomy (PRK) versus thin-flap LASIK: assessment of visual function
ABSTRACT.PURPOSE::
To compare differences in visual acuity, contrast sensitivity, complications, and higher-order ocular aberrations (HOAs) in eyes with stable myopia undergoin... | Intervention: Photo-refractive keratectomy (PRK)
Comparator: Thin-flap laser in situ keratomileusis (LASIK)
Outcome: 1 line or more of CDVA at 6 months | 0 | {"evidence_spans": [{"end": 1470, "start": 1323, "text": " 0.600). Significant differences were not found between treatment groups in contrast sensitivity (P \u2265 0.156) or CDVA (P = 0.800) at postoperative 6"}, {"end": 10858, "start": 10728, "text": " of eyes in the PRK group. At 6 months 64% and 56% of eyes had gai... |
TITLE: Efficacy and Tolerability of Budesonide/Formoterol in One Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Patients with Chronic Obstructive Pulmonary Disease
ABSTRACT:
Background: Combination therapy with a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with... | Intervention: Budesonide/formoterol pMDI 160/9 μg
Comparator: Placebo
Outcome: Mean FEV1 at 12 hours at end of treatment | 1 | {"evidence_spans": [{"end": 20044, "start": 19826, "text": " in the budesonide/formoterol groups. Mean FEV1 at 12 hours and baseline-adjusted average 12-hour FEV1 were significantly improved with both budesonide/formoterol dosages compared with placebo on the day of randomizati"}, {"end": 20045, "start": 19826, "text":... |
TITLE: Effects of Bladder Training and/or Tolterodine in Female Patients with Overactive Bladder Syndrome: A Prospective, Randomized Study
ABSTRACT:
We compared the effects of bladder training and/or tolterodine as first line treatment in female patients with overactive bladder (OAB). One hundred and thirty-nine ... | Intervention: Bladder training plus tolterodine (Co)
Comparator: Bladder training only (BT)
Outcome: Micturition frequency | -1 | {"evidence_spans": [{"end": 944, "start": 846, "text": "). The decrease in frequency was significantly greater in the Co group than in the BT group (p<0.0"}], "id": "383", "pmcid": "2721929", "prompt_id": "383", "split_group_id": "2721929", "votes": {"-1": 2}} |
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