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pubmedcausal_17500
Sample size was small and there was dropout from the study. There was no control group, thus precluding practice and placebo effects and causal relationships
[ [ 70, 86 ] ]
pubmedcausal_27136
Our study comprehensively employed a two-sample MR analysis. We used publicly available genetic data to survey the causal association between PCBC and UGI cancer. We used inverse variance weighting and weighted median for MR analyses and sensitivity analyses to assess heterogeneity and pleiotropy
[ [ 142, 146 ], [ 151, 161 ] ]
pubmedcausal_929
Several studies have shown that early cannabis use is correlated with poor educational performance including high school drop-out. The predominant explanation for this relationship is that cannabis use causes disengagement from education. Another explanation is that the association between early cannabis use and educat...
[ [ 38, 50 ], [ 209, 237 ] ]
pubmedcausal_29421
These results show that PMT inhibits osteoblast differentiation through a mechanism involving the Rho-ROK pathway and that this pathway is an important negative regulator of osteoblast differentiation. Conversely, ROK inhibitors stimulate osteoblast differentiation and may be potentially useful as anabolic agents for b...
[ [ 214, 228 ], [ 229, 265 ], [ 24, 27 ], [ 28, 63 ], [ 98, 113 ] ]
pubmedcausal_13335
Solid-organ transplant recipients are at an increased risk of developing skin cancer; this risk is due to long-term graft-preserving immunosuppressive therapy, and excessive sun exposure is a major contributing factor to this process. The aim of this study was to evaluate the skin cancer awareness and sun-protective be...
[ [ 106, 158 ], [ 164, 186 ] ]
pubmedcausal_27304
A longer educational duration was causally linked with increased BMD. No causal relationship had been found between educational duration and lean mass, time for light-to-moderate PA, milk intake, and alcohol consumption as risk factors for osteoporosis
[ [ 2, 29 ], [ 55, 68 ] ]
pubmedcausal_20879
Perturbed signals arising from the heart cause changes in brain activity, altering mouse behavior. More specifically, the brain interprets augmented myocardial humoral/functional output as a "sustained exercise-like" situation and responds by activating central nervous system output controlling locomotion
[ [ 0, 40 ], [ 47, 72 ] ]
pubmedcausal_24173
The results of this study support a causal role of low birth weight in cardiovascular disease, even after accounting for the influence of the intrauterine environment. This suggests that individuals with a low birth weight may benefit from early targeted cardiovascular disease prevention strategies, independent of whet...
[ [ 51, 67 ], [ 71, 93 ] ]
pubmedcausal_23271
These findings are consistent with a small, causal contribution of childhood maltreatment to mental health problems. Furthermore, the findings suggest that part of the overall risk of mental health problems in individuals exposed to maltreatment is due to wider genetic and environmental risk factors. Therefore, prevent...
[ [ 256, 300 ], [ 164, 245 ] ]
pubmedcausal_26862
Our findings provide new proof of a positive causal relationship between AS and IC in the European population. Notably, it is Acute/Subacute IC, rather than IC as a whole or Chronic IC, that is associated with an elevated risk of AS. These results emphasize the significance of considering AS characteristics in the diag...
[ [ 73, 75 ], [ 80, 109 ] ]
pubmedcausal_21405
The study suggests that the Dobbs ruling has consequences for health systems and reproductive health care that extend beyond denying patients access to the full spectrum of reproductive health services. The finding of a decrease in the expression of trust in clinicians and health information-related terms provides evid...
[ [ 203, 306 ] ]
pubmedcausal_14268
Although antidepressants are well known to cause sexual side effects in adults, the long-term effects of antidepressant use during development on adult sexual function is unknown
[ [ 9, 24 ], [ 49, 78 ] ]
pubmedcausal_16476
Deep sparse autoencoders are particularly suited for treatment effect estimation studies using electronic health records because they can handle high-dimensional covariate sets, large sample sizes, and complex heterogeneity in treatment assignments
[ [ 0, 120 ] ]
pubmedcausal_26504
This study identified the causal relationships between several specific gut microbiota and various neuropathic pain subtypes. Additionally, two immune cells may act as potential mediators in the pathways from gut microbiota to neuropathic pain
[ [ 55, 86 ], [ 91, 124 ] ]
pubmedcausal_5175
Our study found no significant genetic causal association between childhood obesity and delayed puberty or height. However, height was causally associated with childhood obesity. Future research should utilize advanced analytical methods to better understand the determinants of pubertal development
[ [ 66, 83 ], [ 88, 113 ] ]
pubmedcausal_6515
Our findings establish causal relationships between circulating metabolites and thyroiditis, revealing novel mechanistic insights through integrated genomic and metabolomic analyses. These results not only advance our understanding of thyroiditis pathogenesis but also suggest potential biomarkers for disease screening ...
[ [ 52, 75 ], [ 80, 91 ] ]
pubmedcausal_8341
Families with disabled children need more psycho-social considerations. Motherhood care of the children with multiple disabilities is difficult. Due to its importance, the aim of this study was to investigate the causal factors affecting loving care of mothers of children with multiple disabilities
[ [ 168, 299 ] ]
pubmedcausal_5740
EBV infection demonstrates causal links to frailty and fatigue, mediated through specific antibody responses. These findings emphasize EBV's role in chronic inflammatory pathways and highlight potential targets for clinical intervention
[ [ 0, 13 ], [ 43, 50 ], [ 55, 62 ] ]
pubmedcausal_27191
Sepsis is a life-threatening condition that is characterized by multiorgan dysfunction and caused by dysregulated cytokine networks, which are closely associated with sepsis progression and outcomes. However, currently available treatment strategies that target cytokines have failed. Thus, this study aimed to investiga...
[ [ 101, 131 ], [ 0, 6 ] ]
pubmedcausal_22095
The results indicated that the component of DAS, namely "illegal driving", triggered all dimensions of aberrant driving behaviors, whereas hostile gestures had a positive correlation with lapses. In addition, the factor "error" was identified as a significant direct predictor, while the factor "illegal driving" was ide...
[ [ 27, 74 ], [ 75, 129 ] ]
pubmedcausal_28219
Tractor rollovers are a major cause of farm injuries and fatalities. The authors used data from a statewide surveillance study to estimate the prevalence of safety features such as rollover protective structures, seat belts, and power take-off shields on farm tractors in Kentucky
[ [ 0, 17 ], [ 39, 52 ], [ 57, 67 ] ]
pubmedcausal_6519
In conclusion, the study establishes a direct causal link between urolithiasis and OP, independent of environmental factors. Furthermore, mediation analysis showed that bone density and SHBG levels partially mediated the risk of OP in UL patients, suggesting that both mediators may be involved in the mechanism of UL-in...
[ [ 66, 78 ], [ 83, 85 ] ]
pubmedcausal_109
The findings are consistent with the assertion that communication on sexuality issues between adolescents and significant adults results in safer sexual practices, as reflected by condom use, among in-school adolescents. The associations between communication variables and condom use might have been stronger if we had ...
[ [ 52, 128 ], [ 140, 162 ] ]
pubmedcausal_15070
Based on our results, we suggest that a causal relationship exists between reduced histone acetylation and insomnia during alcohol withdrawal
[ [ 75, 102 ], [ 107, 141 ] ]
pubmedcausal_27357
We identified key determinants for breast cancer screening and for the chatbot implementation strategy. Mistrust was a key barrier to both completing breast cancer screening and using the chatbot. We focused design for the initial chatbot interaction to engender trust and developed a CPD to guide chatbot development. W...
[ [ 461, 594 ], [ 606, 641 ] ]
pubmedcausal_22736
This study implied that agreeableness, conscientiousness, and neuroticism were meditating factors between falls and loneliness. In the future, we should consider the big five personality traits more to understand loneliness and offer older people interventions for reducing their loneliness. The study design was cross-s...
[ [ 292, 328 ], [ 413, 452 ], [ 454, 534 ] ]
pubmedcausal_25033
We found genetically predicted UC and CD are causally associated with reduced ALM, and higher hand grip strength reduced IBD and CD risk, and higher ALM reduced IBDs risk. This MR study provides moderate evidence for a bidirectional causal relationship between IBD and sarcopenia
[ [ 9, 33 ], [ 70, 81 ], [ 87, 112 ], [ 142, 152 ], [ 153, 170 ], [ 269, 279 ], [ 121, 124 ] ]
pubmedcausal_20543
The results indicate that CGI is significantly cointegrated with GHE and OPEH in all recipient panels. It indicates that while CGI has significantly positive impacts on GHE and OPEH, its effects vary according to the income level of the underlying economies. The findings support the idea of governance for health and sh...
[ [ 26, 29 ], [ 73, 77 ], [ 65, 68 ] ]
pubmedcausal_21313
The findings highlight that longer exposure to solid fuels used for cooking would be associated with increased odds of major depressive episode. In spite of the uncertainty of causal relationship between them, using solid fuels for cooking can lead to undesirable household air pollution. Reducing the use of solid fuels...
[ [ 210, 239 ], [ 252, 287 ], [ 336, 369 ] ]
pubmedcausal_13919
Presence or emergence of ADHD in early adulthood increases substance problems to a greater degree for women than men. While effects of substances on later ADHD were not statistically significant, detection was limited by the relative rarity of late-adolescent substance symptoms
[ [ 0, 48 ] ]
pubmedcausal_23517
Due to cross-sectionality, it is not possible to establish a causal relationship between CMEs, resilience, and parental distress. Additionally, the study does not provide insights into the underlying factors or processes that contribute to the development of trait resilience
[ [ 7, 25 ], [ 27, 128 ] ]
pubmedcausal_5844
This prospective and MR analysis demonstrated a positive causal relationship between HGB levels and NAFLD. HGB can predict the risk of NAFLD, which can potentially be used as a large-scale non-invasive tool to dynamically monitor the occurrence and development of NAFLD
[ [ 85, 95 ], [ 100, 105 ] ]
pubmedcausal_20434
This study provided evidence of a causal connection between cognitive performance and fracture risk at certain locations. These findings underline the potential of cognitive enhancement strategies as innovative and effective methods for fracture prevention
[ [ 60, 81 ], [ 86, 120 ] ]
pubmedcausal_18149
There is a significant causal relationship between WC/HC and VTE/PE, which is consistent with observational studies. Taking measures to reduce WC/HC of obesity may help reduce the incidence of VTE/PE
[ [ 51, 56 ], [ 61, 67 ] ]
pubmedcausal_21081
Hip fractures are devastating injuries causing disability, dependence, and institutionalisation, yet hospital care is highly variable. This study aimed to determine hospital organisational factors associated with recovery of mobility and change in patient residence after hip fracture
[ [ 0, 13 ], [ 47, 57 ], [ 59, 69 ], [ 75, 95 ] ]
pubmedcausal_25905
This study identifies a significant causal relationship between GERD and increased cancer risk, highlighting its role in cancer development and underscoring the necessity of incorporating GERD management into cancer prevention strategies
[ [ 64, 68 ], [ 73, 94 ] ]
pubmedcausal_5567
We discovered compelling evidence indicating an elevated risk of SAS in individuals with GERD, but no significant evidence supporting an increased risk of GERD in those with SAS. Future investigations into SAS risk should take into account the potential therapeutic targeting of GERD. PPI and histamine antagonists can e...
[ [ 556, 568 ], [ 521, 545 ], [ 573, 597 ], [ 669, 687 ], [ 614, 658 ] ]
pubmedcausal_24301
This study revealed that a significant increase in DR risk was causally related to statins use, providing novel insights into the role of statins in DR. However, further investigations are needed to verify these findings
[ [ 83, 94 ], [ 25, 58 ] ]
pubmedcausal_12694
We illustrate the methods using data from a two-sample MR study to probe the causal effect of systolic blood pressure on coronary heart disease risk, allowing for the possible effects of pleiotropy. The Radial plot is shown to aid the detection of a single outlying variant that is responsible for large differences betw...
[ [ 94, 117 ], [ 121, 148 ] ]
pubmedcausal_15602
Despite the causal relationship between obesity and colon cancer being firmly established, the effect of obesity on the course of cancer calls for further elucidation. The objective of this study was to assess differences in clinical-pathological and psychosocial variables between obese and nonobese individuals with co...
[ [ 40, 47 ], [ 52, 64 ] ]
pubmedcausal_26748
Our study identified a causal relationship between gut microbiota and the increased or decreased risk of diabetic neuropathy. These findings underscore the importance of adopting a comprehensive approach that combines gut microbiota modulation with other therapeutic interventions in the management of diabetic neuropath...
[ [ 51, 65 ], [ 74, 124 ] ]
pubmedcausal_20216
The present study for the first time indicated a significant causal effect of SA on the occurrence of MDD, but the reverse was not true. Enrichment analyses of pleiotropic genes at whole-genome and tissue-specific levels implied the involvement of allergy and immune-related pathways in the shared genetic mechanism of t...
[ [ 78, 80 ], [ 88, 105 ] ]
pubmedcausal_4968
Our MR analysis supports a causal association between CTACK and hypertrophic scars, enhancing our understanding of scar formation and suggesting potential targeted therapeutic strategies for treatment
[ [ 54, 59 ], [ 64, 82 ] ]
pubmedcausal_16130
These findings are consistent with prior observational evidence and support a causal role of higher lifetime smoking amount in the development of breast and colorectal cancer
[ [ 100, 116 ] ]
pubmedcausal_273
Cardiovascular disease is the most common cause of death in Poland, where many factors have been found responsible such as obesity, smoking cigarettes and a lack of physical activity. Amongst these are also nutritional determinants, which principally include the amount and types of dietary fatty acids consumed, coupled...
[ [ 0, 22 ], [ 30, 66 ] ]
pubmedcausal_16504
In multivariate analyses, systolic blood pressure was overall by far the most important risk factor, since it was related to all four CVDs, both in observational and MR analyses. Body mass index was the second most overall important risk factor, being linked to all four CVDs, except ischaemic stroke, both in observatio...
[ [ 544, 552 ], [ 573, 619 ] ]
pubmedcausal_27152
This study demonstrates the effectiveness of combining bootstrap and adversarial learning techniques in policy learning for clinical decision support. It not only enhances the accuracy and reliability of policy evaluation and optimization but also paves avenues for leveraging advanced counterfactual machine learning in...
[ [ 45, 149 ], [ 163, 238 ], [ 248, 331 ] ]
pubmedcausal_20210
Several observational studies and clinical trials have shown that the gut microbiota is associated with urological cancers. However, the causal relationship between gut microbiota and urological cancers remains to be elucidated due to many confounding factors
[ [ 235, 259 ], [ 133, 227 ] ]
pubmedcausal_1779
Individuals who tend to burn are more likely to spend less time in the sun and consequently have lower plasma vitamin D levels and higher susceptibility to prostate cancer
[ [ 0, 74 ], [ 97, 126 ], [ 131, 171 ] ]
pubmedcausal_5009
Our findings reveal the causal relationships between specific immune cells and OA, offering genetic insights into the role of immune cells in OA pathogenesis and guiding the exploration of novel immunological treatments for OA
[ [ 53, 74 ], [ 79, 81 ] ]
pubmedcausal_22693
People with stimulant use disorder have a sophisticated understanding of the complex causal pathways from methamphetamine use to violent behaviour. Their lived experience can make an important contribution to service development
[ [ 193, 228 ] ]
pubmedcausal_6613
Ovarian cancer is a lethal female cancer with a rising incidence that is often diagnosed late due to a lack of symptoms, affecting survival and quality of life. Studies suggest that dietary factors, especially the levels of branched-chain amino acids such as valine, may influence its development. While valine is essent...
[ [ 103, 119 ], [ 0, 93 ] ]
pubmedcausal_26190
Our study found independent causal relationships between four gut microbes and acne vulgaris, and revealed a genetic association between acne vulgaris patients and gut microbiota. Consider preventing and treating acne vulgaris by interfering with the relative content of these four gut microbes
[ [ 57, 74 ], [ 79, 92 ] ]
pubmedcausal_23472
Hemoglobin concentration serves as a protective factor against stroke, and managing abnormal hemoglobin levels can effectively reduce the incidence of stroke
[ [ 75, 110 ] ]
pubmedcausal_3379
Multi-FDBK-BCI training led to significantly greater motor recovery compared to conventional therapy. Functional MRI revealed enhanced activation of high-order transmodal networks-including the default mode, dorsal/ventral attention, and frontoparietal networks-during paralyzed limb movement, with activation strength p...
[ [ 0, 23 ], [ 31, 100 ] ]
pubmedcausal_24119
A causal relationship exists between salt intake and hypertension, stroke, and kidney disease. However, whether or not reduced salt intake slows progression of renal diseases has been intensely debated
[ [ 53, 65 ], [ 67, 73 ], [ 79, 93 ] ]
pubmedcausal_29845
Care of families attending patients' deathbeds is important, leading to care of the bereaved. However, we have no knowledge of a causal relationship between factors of care of terminally ill patients' families and care of families attending patients' deathbeds. The aim of this survey was to find out which factors of ca...
[ [ 214, 260 ], [ 72, 92 ] ]
pubmedcausal_9305
Previous studies found that while internationally financed economic development projects reduced poverty when measured in terms of per capita GDP, they also caused indigenous people to become disassociated, impoverished and alienated minorities whose health status has declined to unacceptable lows when measured in term...
[ [ 34, 88 ], [ 89, 145 ] ]
pubmedcausal_27133
This study provides preliminary evidence of a causal relationship between MVPA and VPA and a reduced risk of sepsis, while prolonged sedentary behaviors such as driving are positively associated with an increased risk of sepsis. These findings provided essential scientific evidence for the development of effective seps...
[ [ 74, 78 ], [ 93, 115 ], [ 75, 78 ] ]
pubmedcausal_8075
Causal life-event explanations decreased lay judgments of the need for treatment, psychological abnormality and stigma
[ [ 0, 30 ] ]
pubmedcausal_26109
Our MR analysis revealed a causal relationship between gut microbiota and male ED. This may contribute to a better understanding of the potential applications of gut microbiota in the occurrence and treatment of male ED
[ [ 55, 69 ], [ 74, 81 ] ]
pubmedcausal_16896
Almost half of the included studies reported implementing a new-user design. Implications of misalignment of study design origin were difficult to assess because it would require explicit reporting of the target estimand in original studies. We recommend that the choice for a particular study time origin is explicitly ...
[ [ 77, 153 ] ]
pubmedcausal_6191
Our results indicate that MetS substantially elevates the risk of TC, while HDL-C may have a protective effect against TC. These findings offer fresh perspectives on the potential causal link between MetS and TC
[ [ 76, 81 ], [ 26, 30 ], [ 31, 68 ] ]
pubmedcausal_23337
CME can significantly improve adult health, including physical and mental health, and the positive effect is more obvious among women, helping to reduce gender differences in health. For the migration distance, attention can be focused on the long-distance migrating individuals, who should get more support
[ [ 0, 3 ] ]
pubmedcausal_1080
The age groups with the peak incidence are the most likely to indulge more in drug abuse in environments with poor drug control. Diagnosis of SJS, SJS/TEN and TEN were missed in many patients at first contact due to the progressive nature of the conditions. Patients needed reviews at regular intervals when IDR was susp...
[ [ 220, 257 ] ]
pubmedcausal_29023
A causal association between cigarette smoking and periodontal disease has been established. The present study examined the association between smoking and tooth loss using national databases in Japan
[ [ 29, 46 ], [ 51, 70 ] ]
pubmedcausal_27377
AS increases the genetically predicted risk for uveitis, iridocyclitis, scleritis, and episcleritis. No potential association of AS with keratitis and optic neuritis was found. It may provide clues for the prevention of AS complications
[ [ 0, 2 ], [ 3, 55 ] ]
pubmedcausal_21445
Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range hyperglycemia. Six weeks later, dextran sodium sulfate was given to induce colitis. In select experiments, a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis onset. Endpoi...
[ [ 64, 78 ], [ 136, 158 ] ]
pubmedcausal_13102
CF significantly impacts on intrauterine growth and leads to lower birth weight in babies with CF, which is only partially explained by shorter gestation
[ [ 0, 2 ], [ 61, 97 ] ]
pubmedcausal_24649
Through genetic analyses, this research demonstrated a significant causal relationship between certain immune cells and MVP, providing new insights for future basic and clinical research
[ [ 95, 115 ], [ 120, 123 ] ]
pubmedcausal_17077
Right hand movement increased connectivity in the left compared to the right hemisphere in controls, while hand movement did not significantly change connectivity in either hemisphere in stroke. Stroke patients with the largest increase in healthy hemisphere connectivity during paretic hand movement had the best arm fu...
[ [ 0, 19 ], [ 20, 99 ] ]
pubmedcausal_5242
Our study provides evidence for the causal associations of different extensive PVS burden phenotypes with neurodegenerative diseases and brain structures, improving our understanding of the complex relationships between different brain injuries
[ [ 59, 132 ], [ 137, 153 ], [ 59, 100 ] ]
pubmedcausal_16367
Our MR estimates suggest that serum lipid and apolipoprotein levels do not cause substantial changes in kidney function. A possible weak effect of higher atherogenic lipids on increased eGFR and UACR warrants further investigation. Processes leading to higher UACR may lead to more atherogenic lipid levels
[ [ 232, 241 ], [ 253, 264 ] ]
pubmedcausal_18487
This MR analysis provides evidence of a positive causal association between RA and pre-eclampsia genetically. Our findings highlight the importance of more intensive prenatal care and early intervention among pregnant women with RA to prevent potential adverse obstetric outcomes. Moreover, our study provides clues for ...
[ [ 76, 78 ] ]
pubmedcausal_38
Older age, male sex, and longer duration of immunosuppressive therapy affect the incidence of infectious skin lesions in patients after kidney transplantation. Treatment with cyclosporine A and azathioprine promotes the development of infectious viral warts
[ [ 160, 189 ] ]
pubmedcausal_405
Although it is difficult to identify single initiatives that may reduce the number of admissions due to excessive anticoagulation, interesting areas include a stronger focus on frequent INR control during the various states of disease and heightened attention to drug-drug interactions
[ [ 104, 129 ], [ 15, 96 ] ]
pubmedcausal_27016
Our study found that genetically predicted SjS increased the risk of PBC and vice versa in a European population. This may shed light on the etiology of PBC and the management of patients with SjS
[ [ 21, 46 ] ]
pubmedcausal_9437
By prevention of risk factors, and prevention of possible cognitive impairment, consequences of stroke can be reduced, the recovery can be made more successful, and quality of life can be improved
[ [ 3, 30 ], [ 80, 196 ], [ 35, 78 ] ]
pubmedcausal_10239
This study refutes that hypothesis that prenatal exposure to APAP causes hyperkinetic dysfunction in mouse offspring. Due to lack of accurate assessment of ADHD in murine models, our results should be taken with caution when compared to the reported clinical data
[ [ 125, 177 ], [ 183, 263 ] ]
pubmedcausal_352
Despite previous studies showing that protease inhibitors decreased Candida adhesion to epithelial cells in vitro, the current study found protease inhibitor-containing antiretroviral therapy predisposed to oropharyngeal yeast colonization in HIV-infected patients
[ [ 38, 57 ] ]
pubmedcausal_6915
In a setting characterized by universal healthcare and widespread access to both office-based OST and HAART, OST substantially increased the odds of HAART adherence. This underlines the need to address barriers to OST globally to reduce the disease burden of both opioid dependence and HIV/AIDS
[ [ 94, 97 ] ]
pubmedcausal_26183
Our study demonstrated that the genetic susceptibility to CD and RA was associated with high risk of sarcopenia, and some sarcopenia-related traits had causal effects on CD or RA
[ [ 117, 147 ], [ 170, 178 ] ]
pubmedcausal_20457
Our study confirmed a causal relationship between GORD and OSA and suggests that intervention measures should be taken for patients with GORD to prevent the occurrence of OSA
[ [ 50, 54 ], [ 59, 62 ] ]
pubmedcausal_27300
This MR study discovered a causal link between H. pylori and AS. Different antibodies have different effects, so future researches are needed to figure out the exact mechanisms behind this link
[ [ 47, 56 ], [ 61, 63 ] ]
pubmedcausal_27578
This study identified a causal relationship between elevated SUA levels and the risk of malignant cervical cancer, particularly cervical adenocarcinoma. These findings provide novel insights into the mechanisms of cervical carcinogenesis and suggest that managing SUA levels could be a potential strategy for cervical ca...
[ [ 52, 71 ], [ 80, 113 ] ]
pubmedcausal_27466
PLS-SEM analysis reveals that health risk behaviors and cognition play a mediating role in impact of the social environment on adverse health outcomes, indicating that individuals with non-fixed employment susceptible to adverse health outcomes. fsQCA analysis identifies that weak social support is a core condition lea...
[ [ 277, 296 ], [ 355, 362 ], [ 340, 350 ] ]
pubmedcausal_16368
The inverse observational association between alcohol use and the risk of CKD or ESKD may have been affected by reverse causation. Our study supports a causal effect of alcohol use on a higher risk of ESKD and related predisposing comorbidities
[ [ 46, 57 ], [ 186, 244 ] ]
pubmedcausal_6130
Cervical cancer remains a global public health challenge, particularly in regions with limited access to screening and vaccination. While high-risk HPV infection is the primary cause, the genetic and molecular mechanisms driving cervical cancer progression are not fully understood
[ [ 138, 161 ], [ 0, 15 ] ]
pubmedcausal_7850
Increasing global urbanisation has resulted in a greater proportion of the world's population becoming exposed to risk factors unique to urban areas, and understanding these effects on public health is essential. The aim of this study was to examine the association between access to green space and mental health among ...
[ [ 0, 30 ], [ 49, 149 ] ]
pubmedcausal_19254
These data show that IRDs are the leading cause of blindness and visual impairment in working-aged persons and children in Austria. Thus, these findings suggest to draw attention to enhance further research in the fields of emerging therapies for IRDs
[ [ 21, 25 ], [ 65, 130 ] ]
pubmedcausal_7992
Within families whose social environment is improving over time, the association between PD exposure and offspring DA outcomes is not causal but is due to familial confounding. Within families whose social environment is deteriorating, the PD-DA association seems to be largely causal. Our measure of PD may also reflect...
[ [ 155, 175 ], [ 65, 126 ] ]
pubmedcausal_21883
Further research into the functional and causal relationships of the observed associations is important to provide guidance regarding coffee/sugar intake on vitamin D status. A well-balanced diet can help prevent vitamin D deficiency and improve the quality of life of patients with HT, especially those in later stages ...
[ [ 175, 195 ], [ 238, 375 ] ]
pubmedcausal_4938
While LTCI has demonstrable short-term benefits in reducing OOPE ratios and improving equity, long-term sustainability remains at risk due to persistent cost escalation. Targeted policy design and enhanced integration with broader health financing mechanisms are needed to strengthen its long-term impact
[ [ 142, 168 ] ]
pubmedcausal_22874
The present study established a bidirectional causal link between RA and hypothyroidism. However, it differs slightly from the findings of prior observational studies, suggesting that future research should concentrate on the interaction mechanisms between RA and hypothyroidism
[ [ 66, 68 ], [ 73, 87 ] ]
pubmedcausal_17297
This work provides evidence that body complexion and circulating lipids traits impact differentially on the risk of FTD and ALS, suggesting new and specific interventional approaches in the control of body lipid metabolism for FTD and ALS, and identified HNRNPK as a potential link between circulating lipids levels and ...
[ [ 33, 48 ], [ 79, 119 ], [ 53, 78 ] ]
pubmedcausal_20098
The development of the field related to the treatment of wounds has resulted in the appearance of new antimicrobial active ingredients
[ [ 4, 63 ], [ 84, 134 ] ]
pubmedcausal_14606
Cognitive integration from multiple disciplines is essential to clinical problem-solving. Because it is not directly observable, demonstrating evidence of learners' cognitive integration remains a challenge. In addition, little is known about preclinical medical students' approach to diagnostic reasoning despite widesp...
[ [ 129, 207 ] ]
pubmedcausal_8156
ADRs were common in patients of MDR-TB on DOTs-Plus drug regimen. It was due to lack of availability of safer and equally potent drugs in DOTs-Plus drug regimen compared to DOTS regimen in non-resistant TB. The frequency and severity of ADRs can be reduced by strict vigilance about known and unknown ADRs, monitoring th...
[ [ 0, 64 ], [ 260, 305 ] ]
pubmedcausal_26188
Mood swings has a significant causal impact on the development of CAD, MI, HF, and stroke, partly mediated by hypertension
[ [ 0, 11 ], [ 51, 69 ] ]
pubmedcausal_18591
Autoimmune bullous diseases are potentially life-threatening dermatoses which present with cutaneous and/or mucosal blisters, diagnosed on the basis of clinical manifestations, direct immunofluorescence of perilesional tissue, and serum testing for circulating autoantibodies. Sometimes, lesions in the navel can lead to...
[ [ 288, 308 ], [ 325, 355 ] ]
End of preview. Expand in Data Studio

This repository integrates the PubMedCausal causal relation extraction corpus into hf datasets. Please find the original dataset here. Please see the citations at the end of this README.

PubMedCausal is a biomedical causal relation extraction corpus built from PubMed abstracts. Pairs are typed along two dimensions:

  • Causality: Explicit / Implicit
  • Sententiality: Intra-sentential / Inter-sentential

There are no countercausal annotations — all relations map to Relation.Procausal.

Statistics

Task Train Test
Causality detection (sentences) 15,000 (1,972 causal) 15,000 (1,973 causal)
Causal candidate extraction 1,972 1,973
Causality identification 1,529 1,528

Usage

Causality Detection

from datasets import load_dataset
dataset = load_dataset("webis/PubMedCausal", "causality detection")

Causal Candidate Extraction

from datasets import load_dataset
dataset = load_dataset("webis/PubMedCausal", "causal candidate extraction")

Causality Identification

from datasets import load_dataset
dataset = load_dataset("webis/PubMedCausal", "causality identification")

Conversion

Data is fetched directly from GitHub at conversion time; no local download is needed.

python conversion_script.py

This produces one parquet per split for each of the three tasks under this directory:

causality-detection/
causal-candidate-extraction/
causality-identification/

Known limitation — unresolvable spans in the identification task

PubMedCausal sometimes records the canonical / normalised form of a span rather than the exact surface text from the sentence. For example:

sentence: "...thus precluding practice and placebo effects..."
effect annotation: "precludes practice"   ← lemmatised, does not match

Because the identification task requires inserting <e1>…</e1> markers at exact character positions, pairs where either span cannot be located verbatim are skipped during conversion. The conversion script prints a warning for each skipped pair and a summary count at the end.

This affects 1,078 train pairs and 997 test pairs (roughly 28% of intra-sentential pairs), predominantly Implicit-causality annotations where the annotator wrote the inferred proposition rather than the surface string. The detection and extraction tasks are unaffected.

Citations

The PubMedCausal paper by Adewole et al., 2025:

@article{kunle-john:2026,
  title = {{{PubMedCausal}}: {{A Span-Level Annotated Corpus}} for {{Causal Relation Extraction}} in {{Biomedical Text}}},
  shorttitle = {{{PubMedCausal}}},
  author = {{Kunle-John}, Ifeoluwa and Paul, Josiah and Agbaakin, Oluwatosin and Aina, Peter and Odezuligbo, Ikenna and Anuyah, Sydney},
  year = 2026,
  journal = {CoRR},
  volume = {abs/2605.28363},
  eprint = {2605.28363},
  doi = {10.48550/ARXIV.2605.28363},
  url = {https://doi.org/10.48550/arXiv.2605.28363},
  urldate = {2026-07-01},
  archiveprefix = {arXiv}
}
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