text stringlengths 497 9.94k | meta dict |
|---|---|
Insulin like growth factor binding protein-7 reduces growth of human breast cancer cells and xenografted tumors.
Previously, we have shown that insulin-like growth factor binding protein-7 (IGFBP-7) expression is inversely correlated with disease progression in breast cancer and is associated with poor outcome. To furt... | {
"pile_set_name": "PubMed Abstracts"
} |
Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology.
1. Two LHRH neuronal cell lines were developed by targeted tumorigenesis of LHRH neurons in vivo. These cell lines (GN and GT-1 cells) represent a homogeneous po... | {
"pile_set_name": "PubMed Abstracts"
} |
Identification and Characterization of the Nucleolar Localization Signal of Autographa californica Multiple Nucleopolyhedrovirus LEF5.
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) late expression factor 5 (LEF5) is highly conserved in all sequenced baculovirus genomes and plays an important role in pro... | {
"pile_set_name": "PubMed Abstracts"
} |
A family of anti-sigma70 proteins in T4-type phages and bacteria that are similar to AsiA, a Transcription inhibitor and co-activator of bacteriophage T4.
Anti-sigma70 factors interact with sigma70 proteins, the specificity subunits of prokaryotic RNA polymerase. The bacteriophage T4 anti-sigma70 protein, AsiA, binds t... | {
"pile_set_name": "PubMed Abstracts"
} |
Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitis.
Aspirin-sensitive rhinosinusitis is a non-allergic, non-infectious perennial eosinophilic rhinitis starting in middle age and rarely seen in children. It may also been seen in atopic patients who have developed a mixed type rhinit... | {
"pile_set_name": "PubMed Abstracts"
} |
The effects of feeding diets containing corn distillers dried grains with solubles, and withdrawal period of distillers dried grains with solubles, on growth performance and pork quality in grower-finisher pigs.
A study was conducted to determine the quantitative effects of feeding amount and withdrawal period of corn ... | {
"pile_set_name": "PubMed Abstracts"
} |
Immunoprecipitation of alpha 2a-adrenergic receptor-GTP-binding protein complexes using GTP-binding protein selective antisera. Changes in receptor/GTP-binding protein interaction following agonist binding.
The nature of the interaction of cloned alpha 2a-adrenergic receptors from LLC-PK1-O clone cells with G proteins ... | {
"pile_set_name": "PubMed Abstracts"
} |
Impact of rotator cuff surgery on postoperative sporting activity.
The aim of this study was to systematically review the literature for the impact of rotator cuff tear (RCT) surgery on postoperative sporting activity in professional and recreational athletes. To identify any published clinical study on return to sport... | {
"pile_set_name": "PubMed Abstracts"
} |
Attenuation of the degenerative effects of endothelin-1 on cartilaginous end plate cells by the endothelin receptor antagonist BQ-123 via the Wnt/β-catenin signaling pathway.
Endothelin-1 (ET-1) is an inflammatory mediator associated with cartilage end plate (CEP) degeneration in the intervertebral disc (IVD). SOX9 is ... | {
"pile_set_name": "PubMed Abstracts"
} |
Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation.
The effect of medetomidine, a highly selective alpha-2-adrenoceptor agonist, on noxious stimulation-induced expression of immediate-early genes was stu... | {
"pile_set_name": "PubMed Abstracts"
} |
Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction.
Cholinergic lesion paradigms have been used to study the role of the cholinergic system in cortical arousal and cognitive function, and its implication in cognitive deficits that occur in... | {
"pile_set_name": "PubMed Abstracts"
} |
[Ethiopathogenesis of gastroesophageal reflux disease].
The primary cause of the gastroesophageal reflux disease is the impairment of motility and not that of acidic secretion. The reflux disease develops when the balance between aggressive and defensive factors becomes disequilibriated. Among the aggressive factors th... | {
"pile_set_name": "PubMed Abstracts"
} |
Maternal behaviour in lactating rats stimulates c-fos in glutamate decarboxylase-synthesizing neurons of the medial preoptic area, ventral bed nucleus of the stria terminalis, and ventrocaudal periaqueductal gray.
Increased activity of the immediate-early gene c-fos can be observed in many areas of the lactating rat br... | {
"pile_set_name": "PubMed Abstracts"
} |
Microvesicles as mediators of intercellular communication in cancer.
The discovery that cancer cells generate large membrane-enclosed packets of epigenetic information, known as microvesicles (MVs), that can be transferred to other cells and influence their behavior (Antonyak et al., Small GTPases 3:219-224, 2012; Cocu... | {
"pile_set_name": "PubMed Abstracts"
} |
Biomechanical evaluation of destabilization following minimally invasive decompression for lumbar spinal canal stenosis.
This study aimed to clarify changes in segmental instability following a unilateral approach for microendoscopic posterior decompression and muscle-preserving interlaminar decompression compared with... | {
"pile_set_name": "PubMed Abstracts"
} |
(18F)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy.
To identify predictive (18F)-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-based parameters for locoregional control, disease-free survi... | {
"pile_set_name": "PubMed Abstracts"
} |
Association of Stimulant Medication Use With Bone Mass in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder.
Murine studies reveal that sympathetic nervous system activation leads to decreased bone mass. Stimulant medications used to treat attention-deficit/hyperactivity disorder (ADHD) increase sy... | {
"pile_set_name": "PubMed Abstracts"
} |
Pharmacological modulation of electromechanical coupling in the proximal and distal regions of the guinea-pig renal pelvis.
1. The effect of drugs affecting calcium and potassium channels and intracellular calcium handling/release on electromechanical coupling in the smooth muscle of the guinea-pig proximal vs. distal ... | {
"pile_set_name": "PubMed Abstracts"
} |
Impact of IGF-1, IGF-1R, and IGFBP-3 promoter methylation on the risk and prognosis of esophageal carcinoma.
The aim of this study is to investigate IGF-1, IGF-1R, and IGFBP-3 methylations in esophageal carcinoma (EC) patients and their relationship with the development and prognosis of EC. This study population consis... | {
"pile_set_name": "PubMed Abstracts"
} |
Salmeterol/fluticasone propionate via Diskus once daily versus fluticasone propionate twice daily in patients with mild asthma not previously receiving maintenance corticosteroids.
The efficacy and safety of twice-daily inhaled salmeterol/fluticasone propionate combination (SFC) therapy have been well established in th... | {
"pile_set_name": "PubMed Abstracts"
} |
A novel camptothecin derivative incorporated in nano-carrier induced distinguished improvement in solubility, stability and anti-tumor activity both in vitro and in vivo.
An oil/water nanoemulsion was developed in the present study to enhance the solubility, stability and anti-tumor activity of a novel 10-methoxy-9-nit... | {
"pile_set_name": "PubMed Abstracts"
} |
Kinetic studies on endo-beta-galactosidase by a novel colorimetric assay and synthesis of N-acetyllactosamine-repeating oligosaccharide beta-glycosides using its transglycosylation activity.
Novel chromogenic substrates for endo-beta-galactosidase were designed on the basis of the structural features of keratan sulfate... | {
"pile_set_name": "PubMed Abstracts"
} |
AMPA receptor regulation mechanisms: future target for safer neuroprotective drugs.
The post-synaptic AMPA receptors play an important role in mediating fast excitatory transmission in the mammalian brain. Over-activated AMPA receptors induce excitotoxicity, implicated in a number of Chronic neurodegenerative disorders... | {
"pile_set_name": "PubMed Abstracts"
} |
[The effect of new generation materials used in reconstructive dentistry on the oral cavity environment].
Loss of teeth impairs the functioning of the stomatognathic system, complicates chewing, interferes with speech, and alters the patient's appearance. Reconstruction of the defects with implants or fixed dentures of... | {
"pile_set_name": "PubMed Abstracts"
} |
GABA(A) receptor-mediated effects on expression of c-Fos in rat trigeminal nucleus following high- and low-intensity afferent stimulation.
We examined the effects of systemic administration of a GABA(A) receptor agonist, muscimol, or antagonist, bicuculline, on the expression of c-Fos protein induced 3h after electrica... | {
"pile_set_name": "PubMed Abstracts"
} |
Alterations during the estrous cycle in the responsiveness of the pituitary to subcutaneous administration of synthetic LH-releasing hormone (LHRH).
To further evaluate the alterations in responsiveness of the pituitary to synthetic LHRH during the proestrous discharge of gonadotropins, LHRH was given SC in the hope of... | {
"pile_set_name": "PubMed Abstracts"
} |
Incorporation of OSI-7836 into DNA of Calu-6 and H460 xenograft tumors.
OSI-7836 (4'-thio-beta-D-arabinofuranosylcytosine) is a novel nucleoside analog in phase I clinical development for the treatment of cancer. As with other nucleoside analogs, the proposed mechanism of action involves phosphorylation to the triphosp... | {
"pile_set_name": "PubMed Abstracts"
} |
[Ruyiping Inhibited Pulmonary Metastasis of Breast Cancer by Regulating the Formation of Pre-metastasis Microenvironment].
Objective To observe the effect of Ruyiping (RYP, a recipe for fighting against re- currence and metastasis of breast cancer) on pre-metastatic microenvironment, and to study its possi- ble mechani... | {
"pile_set_name": "PubMed Abstracts"
} |
Multidrug-resistant NDM-1 Klebsiella outbreak and infection control in endoscopic urology.
What's known on the subject? and What does the study add? Since the first case of multidrug-resistant New Delhi metallo-β-lactamase (NDM-1) Klebsiella and Escherichia coli UTI in January 2008, there have been more reports of case... | {
"pile_set_name": "PubMed Abstracts"
} |
Interleukin 1-stimulated prostacyclin synthesis in endothelium: lack of phospholipase C, phospholipase D, or protein kinase C involvement in early signal transduction.
The cascade of transmembrane signaling events that follow the occupancy of the interleukin 1 receptor remain poorly defined. We examined potential postr... | {
"pile_set_name": "PubMed Abstracts"
} |
Interests in health care technology assessment (HCTA) and HCTA training needs in eight European countries: COMETT-ASSESS.
Between mid-1991 and mid-1992, nearly 300 different organisations involved in European health care contributed their views to a survey covering a range of topics relevant to health care technology a... | {
"pile_set_name": "PubMed Abstracts"
} |
Effects of the irreversible alpha-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in pithed rats.
In pithed normotensive rats, i.v. injection of the selective alpha 1-adrenoceptor agonist cirazoline p... | {
"pile_set_name": "PubMed Abstracts"
} |
Autoantibody profile and clinical patterns in 619 Italian patients with cutaneous lupus erythematosus.
Anti-nuclear antibodies (ANA), anti-extractable nuclear antigens (ENA) and anti-dsDNA antibodies are often associated with cutaneous lupus erythematosus (CLE), with variable frequency depending on skin subtype. Howeve... | {
"pile_set_name": "PubMed Abstracts"
} |
A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors.
Androgenic alopecia, also known as pattern hair loss, is a chronic progressive condition that affects 80% of men and 50% of women throughout a lifetime. But despite its prevalence an... | {
"pile_set_name": "PubMed Abstracts"
} |
Impact of biocontrol strain Pseudomonas fluorescens CHA0 on rhizosphere bacteria isolated from barley (Hordeum vulgare L.) with special reference to Cytophaga-like bacteria.
To assess the impact of the biocontrol strain Pseudomonas fluorescens CHA0 on a collection of barley rhizosphere bacteria using an agar plate inhi... | {
"pile_set_name": "PubMed Abstracts"
} |
Mast cells and hemangioma.
Hemangioma is a primary tumor of the microvasculature in which angiogenesis is initially excessive, followed by spontaneous regression of the newly formed vessels, with the cellular parenchyma gradually being replaced with fibrofatty tissue. Mast cells, which are highly heterogenous in terms ... | {
"pile_set_name": "PubMed Abstracts"
} |
Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation.
Several indices of peptidergic, primary afferent neural transmission in rat at the level of the lumbar spinal cord exhibited differential changes over time in response t... | {
"pile_set_name": "PubMed Abstracts"
} |
Evaluation of coagulation and anti-Xa factor when using a heparin-coated AN69ST® dialyser.
Hemodialysis systems are potentially thrombogenic, so it is routinely used anticoagulation. Its prescription is with risks though which the recommendations regarding the scheduled dose are still based on very different criteria. ... | {
"pile_set_name": "PubMed Abstracts"
} |
Pollinosis etiologic relationship between excessive IL-4 production and down-regulation of the inflammation-suppressive system.
Previous findings suggest a bi-directional relationship between the immune and endocrine systems, which may expand to a major inflammation-regulatory mechanism, although its mechanism is large... | {
"pile_set_name": "PubMed Abstracts"
} |
Promoting neurotrophic effects by GPCR ligands.
The neurotrophins-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3 and NT-4-represent a family of proteins essential for neuronal survival and plasticity. Each neurotrophin can signal through two different transmembrane receptors, Trk receptor tyr... | {
"pile_set_name": "PubMed Abstracts"
} |
Role of CRH in glucopenia-induced adrenomedullary activation in rats.
Acute glucoprivation profoundly stimulated hypothalamic-pituitary-adrenocortical (HPA) and adrenomedullary outflows. Whether these responses reflect a single central mechanism regulated by corticotropin-releasing hormone (CRH) has been unclear. This ... | {
"pile_set_name": "PubMed Abstracts"
} |
Expanding world of ballistosporous yeasts: Distribution in the phyllosphere, systematics and phylogeny.
Ecological and systematic aspects of ballistosporous yeasts inhabiting the phyllosphere of the Asia-Pacific region were reviewed in the light of recent advances. In the past 20 years, the extensive isolation studies ... | {
"pile_set_name": "PubMed Abstracts"
} |
Effects of PCB congeners on the immune function of Mytilus hemocytes: alterations of tyrosine kinase-mediated cell signaling.
Polychlorinated biphenyls (PCBs) are industrial chemicals which have been released into the environment resulting in widespread and persistent contamination. PCBs exist as 209 different congener... | {
"pile_set_name": "PubMed Abstracts"
} |
Relationship between actions of transforming growth factor (TGF)-beta and cell surface expression of its receptors in clonal osteoblastic cells.
Various osteoblastic cell lines were examined for the relationship between the presence of cell-surface transforming growth factor (TGF)-beta receptors and the synthesis of ma... | {
"pile_set_name": "PubMed Abstracts"
} |
[Emodin alleviates pulmonary fibrosis through inactivation of TGF-β1/ADAMTS-1 signaling pathway in rats].
Objective To explore the role of transforming growth factor-β1 (TGF-β1)/a disintegrin-like and metalloproteinase with thrombospondin type 1 motif (ADAMTS-1) signaling pathway in emodin's anti-pulmonary fibrosis. Me... | {
"pile_set_name": "PubMed Abstracts"
} |
In vivo metabolism of apolipoprotein E within the HDL subpopulations LpE, LpE:A-I, LpE:A-II and LpE:A-I:A-II.
High-density lipoproteins can be separated into distinct particles based on their apolipoprotein content. In the present study, the in vivo metabolism of apoE within the apoE-containing HDL particles LpE, LpE:A... | {
"pile_set_name": "PubMed Abstracts"
} |
Evaluation of the selectivity of alpha-adrenoreceptor blocking drugs for postsynaptic alpha 1- and alpha 2-adrenoreceptors in a simple animal model.
1 The increase of diastolic pressure of pithed, normotensive rats was determined after i.v. administration of the alpha-adrenoreceptor agonists L-phenylephrine and B-HT 93... | {
"pile_set_name": "PubMed Abstracts"
} |
Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer.
Chromatin remodeling pathways are critical in the regulation of cancer-related genes and are currently being explored as potential targets for therapeutic intervention. The metasta... | {
"pile_set_name": "PubMed Abstracts"
} |
[Molecular typing of methicillin-resistant Staphylococcus aureus isolated from hospitalized patients in Qingdao].
To explore the molecular types of methicillin-resistant Staphylococcus aureus (MRSA) strains present in major hospitals in Qingdao area, using pulsed-field gel electrophoresis (PFGE) and multilocus sequence... | {
"pile_set_name": "PubMed Abstracts"
} |
Chronic hyperestrogenemia: lack of positive feedback action on gonadotropin-releasing hormone-induced luteinizing hormone release and dual site of negative feedback action.
To test whether sustained midfollicular estrogen concentrations sensitize the pituitary response to GnRH in the continued presence of a GnRH stimul... | {
"pile_set_name": "PubMed Abstracts"
} |
Hormones: what the testis really sees.
Various barriers in the testis may prevent hormones from readily reaching the cells they are supposed to stimulate, especially the hydrophilic hormones from the pituitary. For example, LH must pass through or between the endothelial cells lining the blood vessels to reach the surf... | {
"pile_set_name": "PubMed Abstracts"
} |
Autonomic nervous system activity in essential hypertension: a comparison between dippers and non-dippers.
The present study was undertaken to investigate the changes in autonomic nervous system activity in essential hypertension. Fourteen normotensive controls and 33 age-matched untreated hypertensive subjects, diagno... | {
"pile_set_name": "PubMed Abstracts"
} |
Study of Pemetrexed-based Chemotherapy for Patients with Locally Advanced or Metastatic Cancers.
This study was conducted to observe the efficacy and safety of pemetrexed based chemotherapy in treating patients with locally advanced or metastatic cancers as first-line, second-line or third-line therapy. From May 2011 t... | {
"pile_set_name": "PubMed Abstracts"
} |
Distinctive spatiotemporal expression patterns for neurotrophins develop in gustatory papillae and lingual tissues in embryonic tongue organ cultures.
Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) mRNAs are expressed in the developing rat tongue and taste organs in specific spatiotemporal patterns.... | {
"pile_set_name": "PubMed Abstracts"
} |
'Why didn't you write a not-for-cardiopulmonary resuscitation order?' Unexpected death or failure of process?
Objective The aim of the present study was to understand the reasons for the delivery of non-beneficial cardiopulmonary resuscitation (CPR) attempts in a tertiary private hospital over 12 months. We determined ... | {
"pile_set_name": "PubMed Abstracts"
} |
Sasanquasaponin ΙΙΙ from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells.
Melanoma is a high fatality skin cancer which lacks effective drugs. Sasanquasaponin, an important sort of constituents in theaceae, has been demonstrated to have potent a... | {
"pile_set_name": "PubMed Abstracts"
} |
Osseointegration in porous coated knee arthroplasty. The influence of component coating type in sheep.
Although cementless knee arthroplasty is a commonly performed procedure, to date very little was known about the process of osseointegration of knee arthroplasty components. Using a knee prosthesis that was specially ... | {
"pile_set_name": "PubMed Abstracts"
} |
The relationship between neutrophil-lymphocyte ratio and onset of lactation among postpartum women: A prospective observational cohort study.
Delayed onset of lactation is a key factor in the low rate of exclusive breast-feeding in 6 months after caesarean section. The mechanism of delayed onset of lactation is not cle... | {
"pile_set_name": "PubMed Abstracts"
} |
Diastereomerically Pure 6R- and 6S-3'-Aza-2'-18F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor-Positive KB Tumors.
The aim of this study was to develop the radiosyntheses of diastereomerically pure 6R- and 6S-3'-aza-2'-18F-fluoro-5-methyltetrahydrofolate (MTHF) (6R-18F-1 and 6S-18... | {
"pile_set_name": "PubMed Abstracts"
} |
Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene.
1,3-Butadiene is an important industrial chemical used in the production of synthetic rubber and is also found in gasoline and combustion products. It is a multispecies, multisite carcinogen in r... | {
"pile_set_name": "PubMed Abstracts"
} |
Localization of quinolinic acid metabolizing enzymes in the rat brain. Immunohistochemical studies using antibodies to 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase.
Specific antibodies raised in rabbits against 3-hydroxyanthranilic acid oxygenase (EC 1.13.11.6) and quinolinic acid p... | {
"pile_set_name": "PubMed Abstracts"
} |
Evaluation of localization errors for craniospinal axis irradiation delivery using volume modulated arc therapy and proposal of a technique to minimize such errors.
To dosimetrically evaluate the effects of improper patient positioning in the junction area of a VMAT cranio-spinal axis irradiation technique consisting o... | {
"pile_set_name": "PubMed Abstracts"
} |
Intra-articular injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transected knee in rats: role of excitatory amino acids.
Our present study examined the effect of intra-articular cyclooxygenase-2 (COX-2) inhibitor parecoxib on osteoarthritis (OA) ... | {
"pile_set_name": "PubMed Abstracts"
} |
Formation of 7-hydroxymethotrexate polyglutamyl derivatives and their cytotoxicity in human chronic myelogenous leukemia cells, in vitro.
The rapid synthesis of poly-gamma-glutamyl derivatives of 7-hydroxymethotrexate (7-OH-MTX) and their selective intracellular retention are reported in human chronic myelogenous leuke... | {
"pile_set_name": "PubMed Abstracts"
} |
Mutations in the protease gene of human immunodeficiency virus type 1 affect release and stability of virus particles.
The expression of the pol gene of human immunodeficiency virus type 1 (HIV-1) occurs by a ribosomal frameshift between the gag and the pol genes. The Gag-Pol polyprotein is produced at levels of 5 to 1... | {
"pile_set_name": "PubMed Abstracts"
} |
Association of clopidogrel treatment with risk of mortality and cardiovascular events following myocardial infarction in patients with and without diabetes.
Pharmacodynamic studies have shown that persistently high platelet reactivity is common in patients with diabetes in spite of clopidogrel treatment. Clinical trial... | {
"pile_set_name": "PubMed Abstracts"
} |
End of preview. Expand in Data Studio
README.md exists but content is empty.
- Downloads last month
- 6