tkukurin/ctd-commons-manifest

CTD Commons Dataset Manifest

See GitHub Repository for source and build scripts for this dataset.

Dataset manifest mapping files from the CTD Commons initiative. The initiative acquires, de-identifies, and publishes regulatory dossiers from bankrupt or defunct biotechs to prevent clinical trial data loss.

This manifest provides structured metadata and stable checksums for heterogeneous regulatory files (PDFs, XPTs, SAS scripts) hosted on archive.icosian.net.

Data Structure

• id (string): SHA-256 hash of accession ID and relative path.
• accession (string): CTD accession identifier (e.g., RDCP-A26-0001).
• drug (string): Associated drug name (e.g., ALLN-177).
• name (string): Original file name.
• source_url (string): HTTPS URL to the raw file on the Icosian archive.
• source_path (string): Relative file path in the original eCTD hierarchy.
• extension (string): File extension.
• media_type (string): MIME type or document category.
• parents (list): Directory ancestry.
• size_bytes (int): File size.
• sha256 (string): SHA-256 content checksum.

Source Data

CTD data is product- and submission-centred. It preserves the evidence trail around a drug, including eCTD structures, CMC, nonclinical material, protocols, Clinical Study Reports (CSRs), and CDISC datasets.

• RDCP-A26-0001 / 0002 / 0003: Full eCTD submission for ALLN-177 (reloxaliase, Allena Pharma). Contains ~3,639 files including per-study CSRs, protocols, TLFs, and CDISC datasets (.xpt, .sas7bdat).
• RDCP-E26-EMA: EMA European Public Assessment Reports (EPAR) corpus documents.