README.md

metadata

license: other
tags:
  - gwas
  - polygenic-risk-score
  - psychiatric-genetics
  - pgc

Major Depressive Disorder GWAS Summary Statistics (PGC)

Mirror of Psychiatric Genomics Consortium (PGC) summary statistics for Major Depressive Disorder (mdd2025), redistributed in a single Apache Parquet file for use with OpenMed Genomics.

Source

• Primary citation: Als et al., Nature Medicine 2025; Howard et al., Nature Neuroscience 2019
• Original distributor: Psychiatric Genomics Consortium (https://pgc.unc.edu/for-researchers/download-results/)

This mirror exists only because the upstream OpenMed mirror became inaccessible. No modifications have been made to the underlying data; per-shard parquet files were concatenated into a single file for convenient streaming.

File

pgc-mdd_mdd2025.parquet -- one Apache Parquet file containing the full summary statistics table in the PGC's published schema (SNP, CHR, BP, A1, A2, FRQ, OR/BETA, SE, P, ...).

Usage

import polars as pl
df = pl.read_parquet(
    "https://huggingface.co/datasets/turmex2/pgc-mdd/resolve/main/pgc-mdd_mdd2025.parquet"
)

License & terms of use

PGC summary statistics are released for non-commercial research use only. Do not attempt to re-identify individuals. Results derived from these data are not a clinical diagnosis. See the original publication for the full data-use agreement.