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--- |
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license: apache-2.0 |
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--- |
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We downloaded a total of 2525 ClinVar datasets from the official ProteinGym. Since the official did not provide the corresponding structure files, we performed the following operations to obtain the structures: |
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1. According to the sequence, we retrieved the corresponding UniProt ID from the UniProt website and downloaded 2302 corresponding AlphaFold2 structures. |
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2. For the remaining proteins, we first folded them using ColabFold 1.5.5. |
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3. Among them, 12 proteins were too long to fold, and we solved this problem using the AlphaFold3 server. |
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## 📑 Github |
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https://github.com/tyang816/ProtSSN |
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## 🙌 Citation |
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Please cite our work if you have used our code or data for **dry experiment testing/wet experiment directed evolution**. We are pleased to see improvements in the subsequent work. |
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``` |
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@article{tan2023protssn, |
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title={Semantical and Topological Protein Encoding Toward Enhanced Bioactivity and Thermostability}, |
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author={Tan, Yang and Zhou, Bingxin and Zheng, Lirong and Fan, Guisheng and Hong, Liang}, |
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journal={bioRxiv}, |
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pages={2023--12}, |
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year={2023}, |
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publisher={Cold Spring Harbor Laboratory} |
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} |
