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} | ['gnd:4017182-6', 'gnd:4134792-4', 'gnd:4127577-9'] | ['Finanzierung', 'Vorbehalt', 'Direkte Demokratie'] | ['jur'] | ['Technische Informationsbibliothek (TIB)'] | [['(isbn13)9783845293219', '(ppn)1048272117', '(doi)10.5771/9783845293219', '(firstid)GBV:1048272117', '(isbn13)9783848751204']] | ['Nomos Verlagsgesellschaft'] | [['(classificationName=ssg)ASIEN', 'Recht', 'Rechtsvergleich', 'public law', '(classificationName=ssg)INTRECHT', 'sachunmittelbare Demokratie', 'relationship', 'Taiwan', 'Weimar', 'Deutschland', '(classificationName=linseach:mapping)jur', 'settlement', 'Rechtsvergleichung', 'Volk', 'Gesetzgebung', 'Vergleich', 'Haushaltsvorbehalt', 'constitutional law', 'legislation', '(classificationName=ddc)342.5124902', '(classificationName=ddc)342.4302', 'Finanzvorbehalt', 'democracy', '(classificationName=bk, id=106410687)86.06 - Rechtsvergleichung, Rechtsvereinheitlichung', 'Sachunmittelbare Demokratie', 'Volksgesetzgebung', '(classificationName=ddc-dbn)340', 'Verhältnis', 'law', 'legal comparison', 'Verfassungsrecht', 'rechtsvergleichend', '(classificationName=bk, id=10642260X)86.44 - Staatsrecht, Verfassungsrecht: Allgemeines', 'Öffentliches Recht', 'Demokratie', 'people', 'Germany', 'comparative law']] | ['Sachunmittelbare Demokratie und Finanzvorbehalt : Entwicklungsmöglichkeiten in Taiwan im Lichte der deutschen Erfahrungen'] | [['Ever since the introduction of elements of direct democracy into constitutional reality, there has always been a tension between it and parliamentary democracy. This book explores the topic of direct democracy, in particular the issue of financial proviso in plebiscitary legislation (Finanzvorbehalt in der Volksgesetzgebung). Financial proviso has been described as a German tradition, yet its applicative scope was controversial even in the Weimar period, which, in spite of various interpretative criteria, it remains up to today. Combining the perspectives of legal dogmatics, comparative law, legal history and legal policy, this work hopes to reach a practical concordance in order to contribute to the development of direct democracy in Germany as well as in Taiwan. The book is particularly suitable for readers who are interested in constitutional law and comparative law, but will also be useful to political scientists.', 'Seit der Anerkennung der Elemente der sachunmittelbaren Demokratie in der Verfassungswirklichkeit besteht zwischen dieser und der parlamentarischen Demokratie nach wie vor ein Spannungsverhältnis. Die Arbeit beschäftigt sich mit dem diesbezüglichen Thema der sachunmittelbaren Demokratie, vor allem mit dem Problem des oft als die „deutsche Tradition“ bezeichneten Finanzvorbehalts in der Volksgesetzgebung, dessen Reichweite aber seit der Weimarer Zeit durch verschiedenen Auslegungskriterien bis heute stets umstritten ist. Es wird versucht, aus rechtsdogmatischen, rechtsvergleichenden, rechtshistorischen und rechtspolitischen Untersuchungsperspektiven eine praktische Konkordanz herzustellen, um zu der Entwicklung der sachunmittelbaren Demokratie sowohl in Deutschland als auch in Taiwan beizutragen.Die Arbeit eignet sich vor allem für an Verfassungsrecht und Rechtsvergleichung Interessierte, richtet sich aber auch an Politikwissenschaftler.']] | ['2019'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['commercial licence'] | [[{'@id': 'gnd:4017182-6'}, {'@id': 'gnd:4134792-4'}, {'@id': 'gnd:4127577-9'}]] | ['gnd:1175666882', 'gnd:2002585-3', 'gnd:4011882-4', 'gnd:4017182-6', 'gnd:4017875-4', 'gnd:4127577-9', 'gnd:4134792-4', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1048272117'] | ['Chen, Pin-Cheng', 'Ludwig-Maximilians-Universität München', 'Deutschland', 'Finanzierung', 'Taiwan', 'Vorbehalt', 'Direkte Demokratie'] | 12 |
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"Feeding today\u2019s dairy cows has to provide for a stable fermentation in the rumen to allow for the desired productivity. Different feed supplements are used to compensate for imbalances or deficiencies of the ration. Studies demonstrate an impact of zeolite supplementation on rumen metabolism. Zeolites \u2013 clinoptilolites, for example \u2013 are negatively charged tectosilicates with pores and channels specific of each framework type. As a consequence, they can selectively bind cations from the surrounding medium and ion-exchange existing channel cations for them. Therefore, the objective of this study was to examine the effect of Klinofeed\u00ae, a clinoptilolite of sedimentary origin, on the fermentation in the fluid phase of the rumen which appears to be the first possible point of action. An artificial rumen (all-glass, bulk incubation type, closed system) corresponding to the one used by CZERKAWSKI and BRECKENRIDGE (1969) was used. Fermentation processes in the rumen liquid were analyzed during six hours of incubation. The following parameters were measured at three different sampling times (0 h, 3 h, 6 h of incubation): redox potential, pH value, concentrations of glucose and volatile fatty acids (acetic, propionic, n-butyric, n-valeric, hexanoic, i-butyric, i-valeric acid and their sum), production of fermentation gases, concentrations of methane, ammonia, microbial protein and nucleobases (cytosine, uracil, thymine, guanine, adenine and their sum), protozoal motility, numbers of protozoa (in total and differentiated according to their size). For the incubation intervals 0\u20133 h, 3\u20136 h and 0\u20136 h the magnitude of the changes, the production or the consumption of the parameters were calculated. Two distinct trials with different zeolite dosages were conducted. The first trial consisted of 45 days when 0,34 g Klinofeed\u00ae were applied in accordance with the producer\u2019s recommended daily amount per animal. In the course of the second trial (eleven days) the double dose of the clinoptilolite (0,68 g) was added. The supplementation of Klinofeed\u00ae moderately changed the fermentation pattern and stabilized the environment (pH value lower in the control fermenters) in both trials. The glucose added as substrate for the microorganisms was almost completely metabolized during the first three hours of incubation under control conditions as well as in the zeolite fermenters without any evidence of an increase in the bacterial matter in the zeolite fermenters (as indicated by the lacking increased production of microbial protein or nucleobases). Hence, it is justified to assume that the increased production of volatile fatty acids (trial 1: +7,8 % n-butyric acid; trial 2: +19,3 % acetic, +8,6 % propionic and +9,9 % n-butyric acid, sum of all measured volatile fatty acids +8,8 %; in each case for the complete incubation and relative to control) and methane [trial 1 (0\u20136 h): +14,4 %; trial 2 (0\u20133 h): +12,5 %] was the result of relative shifts in the rumen microbiome and/or of the metabolic pathways that took place. No further methods were available to substantiate the assumption of a microbiome shift. Neither was the mechanism by which Klinofeed\u00ae could influence the microbiome revealed. This gap in knowledge should be closed in future studies.",
"Die bedarfsgerechte F\u00fctterung heutiger Milchk\u00fche muss eine stabile Pansenfermentation erzeugen, denn nur so k\u00f6nnen die K\u00fche die gew\u00fcnschten Leistungen erbringen. Um dies sicherzustellen, werden verschiedene Futtermittel-zusatzstoffe eingesetzt, die Unausgewogenheiten oder M\u00e4ngel der Ration aus-gleichen. Studien zeigen, dass Zeolithe, zum Beispiel Klinoptilolithe, die infolge ihres Aufbaus (negativ geladene Kristallgitter mit f\u00fcr jeden Gittertyp spezifischen Kan\u00e4len und Hohlr\u00e4umen) selektiv Kationen aus dem umgebenden Milieu aufnehmen und vorhandene Kanalkationen durch diese ersetzen k\u00f6nnen, den Pansenstoffwechsel von Rindern beeinflussen. Aus diesem Grund wurde in der vorliegenden Arbeit die Wirkung von Klinofeed\u00ae, einem Klinoptilolith sediment\u00e4ren Ursprungs, auf die Fermentation im fl\u00fcssigen Panseninhalt des Rindes, als erstem m\u00f6glichem Wirkungsort, unter In-vitro-Bedingungen untersucht. Mit dem verwendeten Kurzzeitsystem nach CZERKAWSKI und BRECKENRIDGE (1969), einem k\u00fcnstlichen Pansen vom geschlossenen Blocktyp, konnten die Fermentationsvorg\u00e4nge in der fl\u00fcssigen Phase des Panseninhalts w\u00e4hrend sechsst\u00fcndiger Inkubation beurteilt werden. Dazu wurden folgende Parameter an drei Probennahmezeitpunkten (0 h, 3 h, 6 h Inkubationsdauer) erfasst: Redoxpotential, pH-Wert, Glucosekonzentration, Konzentrationen der fl\u00fcchtigen Fetts\u00e4uren (Essig-, Propion-, n-Butter-, n-Valerian-, Hexan-, i-Butter- und i-Valerians\u00e4ure sowie deren Summe), Gasproduktion, Methankonzentration, Ammoniakkonzentration, bakterieller Proteingehalt, Konzentrationen der Nukleobasen (Cytosin, Uracil, Thymin, Guanin, Adenin sowie deren Summe), Protozoenmotilit\u00e4t und Anzahl der Protozoen in Summe sowie differenziert nach Gr\u00f6\u00dfe. Aus den Messwerten wurde die Gr\u00f6\u00dfe der Ver\u00e4nderung bzw. die Produktion oder der Verbrauch der Parameter w\u00e4hrend der Inkubationsintervalle 0\u20133 h, 3\u20136 h und 0\u20136 h errechnet. Zwei Versuche mit unterschiedlicher Klinofeed\u00ae-Dosis wurden durchgef\u00fchrt. Im ersten Versuch wurde an 45 Versuchstagen die der F\u00fctterungsempfehlung entsprechende Menge von 0,34 g Klinofeed\u00ae pro Fermenter zugelegt. Im zweiten Versuch (elf Versuchstage) wurde die Dosis auf 0,68 g verdoppelt. Durch die Zulage von Klinofeed\u00ae wurde das Fermentationsmuster in beiden Versuchen moderat ver\u00e4ndert und das Milieu stabilisiert (pH-Wert in den Kontrollfermentern niedriger als in den mit Klinofeed\u00ae versetzten Zulagefermentern). Die als Substrat eingesetzte Glucose wurde sowohl in den Kontroll- als auch in den Zulagefermentern bereits innerhalb der ersten drei Inkubationsstunden beinahe vollst\u00e4ndig verstoffwechselt, ohne dass in den Zulagefermentern eine Vermehrung der Bakterienmasse (bakterielle Protein- bzw. Nukleobasenproduktionen) gegen\u00fcber den Kontrollen belegt werden konnte. Deshalb ist anzunehmen, dass die Steigerungen der Produktion fl\u00fcchtiger Fetts\u00e4uren (Versuch 1: +7,8 % n-Butters\u00e4ure; Versuch 2: +19,3 % Essig-, +8,6 % Propion- und +9,9 % n-Butters\u00e4ure, in Summe aller fl\u00fcchtigen Fetts\u00e4uren +8,8 %; jeweils \u00fcber die Gesamtinkubation und in Relation zur Kontrolle) und der Methanproduktion [Versuch 1 (0\u20136 h): +14,4 %; Versuch 2 (0\u20133 h): +12,5 %] durch relative Verschiebungen innerhalb des Pansenmikrobioms und/oder der benutzten Stoffwechselwege hervorgerufen wurden. Mit den Methoden, die f\u00fcr die eigenen Versuche zur Verf\u00fcgung standen, war es nicht m\u00f6glich, den Erkl\u00e4rungsansatz einer Mikrobiomver\u00e4nderung weiter zu erh\u00e4rten. Auch die Kl\u00e4rung des eigentlichen Wirkmechanismus von Klinofeed\u00ae im Pansen sollte Gegenstand zuk\u00fcnftiger Untersuchungen sein."
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} | ['gnd:4252358-8', 'gnd:4067660-2', 'gnd:4123904-0', 'gnd:4169916-6'] | ['Zeolith', 'Pansen', 'Milchkuh', 'Beifutter'] | ['hor'] | ['Technische Informationsbibliothek (TIB)'] | [['(ppn)1048804054', '(firstid)GBV:1048804054']] | [''] | [['Pansenfermentation', 'Zeolith', 'zeolite', 'Pansensaft', '(classificationName=bk, id=106409158)48.61 - Tierernährung, Tierfutter', '(classificationName=ddc-dbn)630', '(classificationName=linseach:mapping)hor', 'Fermentation', 'rumen fermentation', 'Pansen', 'Rind', 'cattle', 'Futtermittel']] | ['Untersuchungen über die Wirkungen von Zeolithzulagen auf die Pansenfermentation des Rindes in vitro'] | [['Feeding today’s dairy cows has to provide for a stable fermentation in the rumen to allow for the desired productivity. Different feed supplements are used to compensate for imbalances or deficiencies of the ration. Studies demonstrate an impact of zeolite supplementation on rumen metabolism. Zeolites – clinoptilolites, for example – are negatively charged tectosilicates with pores and channels specific of each framework type. As a consequence, they can selectively bind cations from the surrounding medium and ion-exchange existing channel cations for them. Therefore, the objective of this study was to examine the effect of Klinofeed®, a clinoptilolite of sedimentary origin, on the fermentation in the fluid phase of the rumen which appears to be the first possible point of action. An artificial rumen (all-glass, bulk incubation type, closed system) corresponding to the one used by CZERKAWSKI and BRECKENRIDGE (1969) was used. Fermentation processes in the rumen liquid were analyzed during six hours of incubation. The following parameters were measured at three different sampling times (0 h, 3 h, 6 h of incubation): redox potential, pH value, concentrations of glucose and volatile fatty acids (acetic, propionic, n-butyric, n-valeric, hexanoic, i-butyric, i-valeric acid and their sum), production of fermentation gases, concentrations of methane, ammonia, microbial protein and nucleobases (cytosine, uracil, thymine, guanine, adenine and their sum), protozoal motility, numbers of protozoa (in total and differentiated according to their size). For the incubation intervals 0–3 h, 3–6 h and 0–6 h the magnitude of the changes, the production or the consumption of the parameters were calculated. Two distinct trials with different zeolite dosages were conducted. The first trial consisted of 45 days when 0,34 g Klinofeed® were applied in accordance with the producer’s recommended daily amount per animal. In the course of the second trial (eleven days) the double dose of the clinoptilolite (0,68 g) was added. The supplementation of Klinofeed® moderately changed the fermentation pattern and stabilized the environment (pH value lower in the control fermenters) in both trials. The glucose added as substrate for the microorganisms was almost completely metabolized during the first three hours of incubation under control conditions as well as in the zeolite fermenters without any evidence of an increase in the bacterial matter in the zeolite fermenters (as indicated by the lacking increased production of microbial protein or nucleobases). Hence, it is justified to assume that the increased production of volatile fatty acids (trial 1: +7,8 % n-butyric acid; trial 2: +19,3 % acetic, +8,6 % propionic and +9,9 % n-butyric acid, sum of all measured volatile fatty acids +8,8 %; in each case for the complete incubation and relative to control) and methane [trial 1 (0–6 h): +14,4 %; trial 2 (0–3 h): +12,5 %] was the result of relative shifts in the rumen microbiome and/or of the metabolic pathways that took place. No further methods were available to substantiate the assumption of a microbiome shift. Neither was the mechanism by which Klinofeed® could influence the microbiome revealed. This gap in knowledge should be closed in future studies.', 'Die bedarfsgerechte Fütterung heutiger Milchkühe muss eine stabile Pansenfermentation erzeugen, denn nur so können die Kühe die gewünschten Leistungen erbringen. Um dies sicherzustellen, werden verschiedene Futtermittel-zusatzstoffe eingesetzt, die Unausgewogenheiten oder Mängel der Ration aus-gleichen. Studien zeigen, dass Zeolithe, zum Beispiel Klinoptilolithe, die infolge ihres Aufbaus (negativ geladene Kristallgitter mit für jeden Gittertyp spezifischen Kanälen und Hohlräumen) selektiv Kationen aus dem umgebenden Milieu aufnehmen und vorhandene Kanalkationen durch diese ersetzen können, den Pansenstoffwechsel von Rindern beeinflussen. Aus diesem Grund wurde in der vorliegenden Arbeit die Wirkung von Klinofeed®, einem Klinoptilolith sedimentären Ursprungs, auf die Fermentation im flüssigen Panseninhalt des Rindes, als erstem möglichem Wirkungsort, unter In-vitro-Bedingungen untersucht. Mit dem verwendeten Kurzzeitsystem nach CZERKAWSKI und BRECKENRIDGE (1969), einem künstlichen Pansen vom geschlossenen Blocktyp, konnten die Fermentationsvorgänge in der flüssigen Phase des Panseninhalts während sechsstündiger Inkubation beurteilt werden. Dazu wurden folgende Parameter an drei Probennahmezeitpunkten (0 h, 3 h, 6 h Inkubationsdauer) erfasst: Redoxpotential, pH-Wert, Glucosekonzentration, Konzentrationen der flüchtigen Fettsäuren (Essig-, Propion-, n-Butter-, n-Valerian-, Hexan-, i-Butter- und i-Valeriansäure sowie deren Summe), Gasproduktion, Methankonzentration, Ammoniakkonzentration, bakterieller Proteingehalt, Konzentrationen der Nukleobasen (Cytosin, Uracil, Thymin, Guanin, Adenin sowie deren Summe), Protozoenmotilität und Anzahl der Protozoen in Summe sowie differenziert nach Größe. Aus den Messwerten wurde die Größe der Veränderung bzw. die Produktion oder der Verbrauch der Parameter während der Inkubationsintervalle 0–3 h, 3–6 h und 0–6 h errechnet. Zwei Versuche mit unterschiedlicher Klinofeed®-Dosis wurden durchgeführt. Im ersten Versuch wurde an 45 Versuchstagen die der Fütterungsempfehlung entsprechende Menge von 0,34 g Klinofeed® pro Fermenter zugelegt. Im zweiten Versuch (elf Versuchstage) wurde die Dosis auf 0,68 g verdoppelt. Durch die Zulage von Klinofeed® wurde das Fermentationsmuster in beiden Versuchen moderat verändert und das Milieu stabilisiert (pH-Wert in den Kontrollfermentern niedriger als in den mit Klinofeed® versetzten Zulagefermentern). Die als Substrat eingesetzte Glucose wurde sowohl in den Kontroll- als auch in den Zulagefermentern bereits innerhalb der ersten drei Inkubationsstunden beinahe vollständig verstoffwechselt, ohne dass in den Zulagefermentern eine Vermehrung der Bakterienmasse (bakterielle Protein- bzw. Nukleobasenproduktionen) gegenüber den Kontrollen belegt werden konnte. Deshalb ist anzunehmen, dass die Steigerungen der Produktion flüchtiger Fettsäuren (Versuch 1: +7,8 % n-Buttersäure; Versuch 2: +19,3 % Essig-, +8,6 % Propion- und +9,9 % n-Buttersäure, in Summe aller flüchtigen Fettsäuren +8,8 %; jeweils über die Gesamtinkubation und in Relation zur Kontrolle) und der Methanproduktion [Versuch 1 (0–6 h): +14,4 %; Versuch 2 (0–3 h): +12,5 %] durch relative Verschiebungen innerhalb des Pansenmikrobioms und/oder der benutzten Stoffwechselwege hervorgerufen wurden. Mit den Methoden, die für die eigenen Versuche zur Verfügung standen, war es nicht möglich, den Erklärungsansatz einer Mikrobiomveränderung weiter zu erhärten. Auch die Klärung des eigentlichen Wirkmechanismus von Klinofeed® im Pansen sollte Gegenstand zukünftiger Untersuchungen sein.']] | ['2018'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4252358-8'}, {'@id': 'gnd:4067660-2'}, {'@id': 'gnd:4123904-0'}, {'@id': 'gnd:4169916-6'}]] | ['gnd:4067660-2', 'gnd:4123904-0', 'gnd:4169916-6', 'gnd:4252358-8', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1048804054'] | ['Zeolith', 'Pansen', 'Milchkuh', 'Beifutter'] | 10 |
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} | ['gnd:4160891-4', 'gnd:4029919-3'] | ['Katalysator', 'Hydrierung'] | ['che'] | ['gnd:136114784'] | [['(doi)10.18453/rosdok_id00002403', '(ppn)1048999467', '(firstid)GBV:1048999467']] | ['Universität'] | [['(classificationName=ddc)540', '(classificationName=ddc-dbn)660', '(classificationName=linseach:mapping)che', 'Katalysator', 'Aufbereitung', '(classificationName=ddc-dbn)661.8', 'Biomasse', 'Chemische Synthese', '(classificationName=bk, id=106417266)35.17 - Katalyse']] | ['Bio-based building blocks from 5-hydroxymethylfurfural via 1-hydroxyhexane-2,5-dione as intermediate'] | ['This dissertation reports on the synthesis and applications of the biomass-derived 1-hydroxyhexane-2,5-dione (HHD). A new catalytic process was developed for the hydrogenation/hydrolytic ring opening of 5-hydroxymethylfurfural (5-HMF) resulting in the formation of HHD in good yields. Furthermore, HHD was converted to useful follow-up products including pyrroles and cyclopentanone derivatives. Additionally, readily accessible rhenium(VII) oxide was used for the catalytic deoxydehydration of renewable triols under solvent-free and aerobic conditions resulting in formation of the hydroxy-alkenes.<eng>'] | ['2018'] | ['http://id.loc.gov/vocabulary/iso639-1/en'] | ['open access'] | [[{'@id': 'gnd:4160891-4'}, {'@id': 'gnd:4029919-3'}]] | ['gnd:117790103X', 'gnd:136114784', 'gnd:2147083-2', 'gnd:38329-6', 'gnd:4029919-3', 'gnd:4160891-4', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1048999467'] | ['Woźniak, Bartosz', 'Barta, Katalin', 'Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät', 'Universität Rostock', 'Katalysator', 'Hydrierung'] | 5 |
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"title": "Evaluation of fertilization capacity of cryopreserved stallion sperm, directly after thawing and after cooled storage",
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"In the modern equine breeding industry, use of cryopreserved semen is increasing. In comparison to using fresh or cooled semen, however, costs are higher and pregnancy rates lower. This is associated with the fact that using cryopreserved sperm requires special equipment for transport, storage and handling. Furthermore, sperm viability is reduced after cryopreservation, and cryopreserved semen therefore needs to be used for insemination close to ovulation. The aim of the studies described in this thesis was to investigate if cryopreserved semen maintains its fertilizing ability after thawing and cooled overnight transport (i.e. 24 h storage at 4\u00b0C). Furthermore, it was tested if performing insemination at a defined time point after hCG application was as effective as performing insemination close to ovulation (with inspection every 6 h). These simplifications would reduce costs and make cryopreserved insemination doses available to more practitioners and breeders. This study was divided in three parts. (1) First, viability of cryopreserved stallion sperm was determined in vitro; directly after thawing, after dilution with different extenders as well as an additional 24 h cooled storage. For cooled storage, to mimic transport conditions, thawed cryopreserved semen was diluted, transferred to a syringe and placed in a polystyrene transport box with a cool pack for maintenance at 4\u00b0C. Sperm plasma- and acrosomal membrane integrity was determined using flow cytometric analysis. Motility characteristics were evaluated using computer assisted sperm analysis (CASA). Only small differences were found between percentages of membrane intact sperm directly after thawing and after an additional 24 h cooled storage, irrespective of the extender used for dilution. Furthermore, percentages of progressively motile sperm were only 3\u22128% decreased after 1 d cooled storage. (2) Then, for testing fertilizing potential of cryopreserved sperm in vitro, a heterologous oocyte-binding assay was used. Therefore, cryopreserved stallion sperm was co-incubated with porcine oocytes in capacitation as well as control-medium, after which nuclei were stained and the number of sperm per oocyte/zona was counted. Sperm-oocyte binding was determined to be higher in capacitation than in control medium, and if using diluted versus cryopreserved sperm. Furthermore, the number of sperm bound per oocyte was not negatively affected if cryopreserved sperm was subjected to dilution and 1 d cooled storage after thawing, suggesting that fertilizing capacity was maintained. (3) Finally, an insemination trial was performed to determine mare pregnancy rates using cryopreserved stallion sperm directly after thawing as well as after 24\u221236 h cooled storage after thawing. In addition, different insemination regimes were tested, including insemination after a defined duration after hCG-administration as well as maximally 6 h after ovulation (i.e. determined according to ultrasound ovulation controls). The insemination trial revealed that pregnancy rates achieved with using cryopreserved sperm after thawing and 1 d cooled storage (13/25, 52%) were not significantly different from when using freshly thawed sperm (7/10, 70%), nor were pregnancy rates negatively affected if insemination was planned according to the moment of hCG application instead of ovulation controls. Taken together, viability and fertilizing capacity of cryopreserved stallion semen is not negatively affected if stored at 4\u00b0C for up to 24\u221236 h after thawing. Moreover, if used for artificial insemination, mare pregnancy rates are similar as those obtained with using freshly thawed sperm.",
"Der Einsatz von Tiefgefriersamen in der modernen Pferdezucht nimmt zu, ist jedoch im Vergleich zu Frisch- und K\u00fchlsamen mit h\u00f6heren Kosten und geringeren Tr\u00e4chtigkeitsraten verbunden. Ursachen daf\u00fcr sind, dass f\u00fcr die Verwendung von Tiefgefriersamen eine spezielle Ausr\u00fcstung f\u00fcr Transport, Lagerung und Besamung ben\u00f6tigt wird und eine Besamung nah am Zeitpunkt der Ovulation erfolgen muss. Das Ziel der in dieser Arbeit beschriebenen Studien war herauszufinden, ob Tiefgefriersamen seine Fertilisationsf\u00e4higkeit nach Auftauen und gek\u00fchltem Transport \u00fcber Nacht (also 24 Stunden Lagerung bei 4\u00b0C) erh\u00e4lt. Au\u00dferdem wurde getestet, ob eine Besamung zu definierten Zeitpunkten nach hCG-Applikation genauso effektiv ist wie eine Besamung nah am Zeitpunkt der Ovulation (nach Ultraschallkontrolle alle 6 Stunden). Dieses Vorgehen w\u00fcrde Kosten reduzieren und Tiefgefriersamen einer breiteren Masse an Z\u00fcchtern und Praktikern zug\u00e4nglich machen. Diese Studie besteht aus drei Teilen: (1) als erstes wurde die Viabilit\u00e4t von Tiefgefriersamen in vitro bestimmt; direkt nach dem Auftauen, nach Verd\u00fcnnung mit verschiedenen Verd\u00fcnnern und nach einer 24-st\u00fcndigen Lagerung bei 4\u00b0C. Der Samen wurde nach Auftauen und Verd\u00fcnnung in einer Spritze in einer Polystyrol-K\u00fchlbox bei 4\u00b0C wie K\u00fchlsamen gelagert. Die Plasma- und Akrosommembranintegrit\u00e4t wurde durch flowzytometrische Messungen bestimmt, die Motilit\u00e4t und Bewegungsmuster der Spermien mittels Computer assistierter Spermienanalyse (CASA). Es wurden nur geringe Unterschiede membranintakter Spermien zwischen direkt nach dem Auftauen und nach 24 Stunden gek\u00fchlter Lagerung gefunden, unabh\u00e4ngig vom verwendeten Verd\u00fcnner. Au\u00dferdem waren die Anteile progressiv motiler Spermien nur 3-8% niedriger nach 24 Stunden gek\u00fchlter Lagerung. (2) Zur Bestimmung der Fertilisationsf\u00e4higkeit kryokonservierter Spermien in vitro wurden heterologe Oozyten-Bindungsassays durchgef\u00fchrt. Kryokonservierte equine Spermien wurden mit porcinen Oozyten in Kapazitations- und Kontrollmedium koinkubiert, anschlie\u00dfend wurden die Zellkerne angef\u00e4rbt und die Anzahl der gebundenen Spermen pro Oozyte bestimmt. Die Spermien-Oozyten-Bindung ist h\u00f6her in Kapazit\u00e4ts- als in Kontrollmedium und h\u00f6her bei Verwendung verd\u00fcnnter versus kryokonservierter Spermien. Au\u00dferdem wird die Anzahl gebundener Spermien nicht negativ beeinflusst durch die Verd\u00fcnnung und gek\u00fchlte Lagerung von kryokonservierten Spermien nach dem Auftauen f\u00fcr 24h, was darauf schlie\u00dfen l\u00e4sst, dass die Fertilisationsf\u00e4higkeit erhalten bleibt. (3) Schlie\u00dflich wurde ein Besamungsversuch durchgef\u00fchrt zur Bestimmung der Tr\u00e4chtigkeitsraten von Stuten unter Verwendung kryokonservierter Spermien direkt nach dem Auftauen sowie nach 24-36 Stunden gek\u00fchlter Lagerung nach dem Auftauen. Es wurden verschiedene Besamungsregimes verglichen, einschlie\u00dflich Besamung nach einer definierten Zeit nach hCG-Applikation, sowie maximal 6 Stunden nach Ovulation, welche per Ultraschallkontrolle bestimmt wurde. Der Besamungsversuch zeigte, dass Tr\u00e4chtigkeitsraten weder bei Nutzung von kryokonservierten Spermien nach Auftauen und 24 Stunden Lagerung (12/22, 59%) signifikant niedriger sind als bei Nutzung von frisch aufgetautem Sperma (7/10, 70%) noch bei Planung von Besamungen anhand des Zeitpunkts der Applikation von hCG anstatt per Ovulationskontrolle. Zusammengefasst ist die Viabilit\u00e4t und Fertilisationskapazit\u00e4t von kryokonservierten Spermien nicht negativ beeinflusst nach Lagerung f\u00fcr 24-36 Stunden bei 4\u00b0C nach dem Auftauen. Bei Verwendung dieser Spermien f\u00fcr die Besamung sind die Tr\u00e4chtigkeitsraten von Stuten \u00e4hnlich wie bei Verwendung von frisch aufgetautem Samen."
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"alternative": "Untersuchungen zur Befruchtungsf\u00e4higkeit von Hengsttiefgefriersperma nach Auftauen und nach gek\u00fchlter Lagerung",
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} | ['gnd:4114638-4', 'gnd:4024379-5', 'gnd:4231333-8', 'gnd:4156264-1', 'gnd:4135383-3'] | ['Hengst', 'Motilität', 'Spermium', 'Gefriertrocknung', 'Fertilitätsdiagnostik'] | ['hor'] | [['Oldenhof, Hariëtte', 'Sieme, Harald']] | [['(firstid)GBV:1049235541', '(ppn)1049235541']] | [''] | [['Besamung', '(classificationName=ddc-dbn)630', 'Oocyten-Bindungsassay', '(classificationName=linseach:mapping)hor', 'oocyte binding assay', 'Hengst-Tiefgefriersperma', 'cryopreserved stallion semen', '(classificationName=bk, id=106410474)48.64 - Tierzucht', 'insemination']] | ['Evaluation of fertilization capacity of cryopreserved stallion sperm, directly after thawing and after cooled storage'] | [['In the modern equine breeding industry, use of cryopreserved semen is increasing. In comparison to using fresh or cooled semen, however, costs are higher and pregnancy rates lower. This is associated with the fact that using cryopreserved sperm requires special equipment for transport, storage and handling. Furthermore, sperm viability is reduced after cryopreservation, and cryopreserved semen therefore needs to be used for insemination close to ovulation. The aim of the studies described in this thesis was to investigate if cryopreserved semen maintains its fertilizing ability after thawing and cooled overnight transport (i.e. 24 h storage at 4°C). Furthermore, it was tested if performing insemination at a defined time point after hCG application was as effective as performing insemination close to ovulation (with inspection every 6 h). These simplifications would reduce costs and make cryopreserved insemination doses available to more practitioners and breeders. This study was divided in three parts. (1) First, viability of cryopreserved stallion sperm was determined in vitro; directly after thawing, after dilution with different extenders as well as an additional 24 h cooled storage. For cooled storage, to mimic transport conditions, thawed cryopreserved semen was diluted, transferred to a syringe and placed in a polystyrene transport box with a cool pack for maintenance at 4°C. Sperm plasma- and acrosomal membrane integrity was determined using flow cytometric analysis. Motility characteristics were evaluated using computer assisted sperm analysis (CASA). Only small differences were found between percentages of membrane intact sperm directly after thawing and after an additional 24 h cooled storage, irrespective of the extender used for dilution. Furthermore, percentages of progressively motile sperm were only 3−8% decreased after 1 d cooled storage. (2) Then, for testing fertilizing potential of cryopreserved sperm in vitro, a heterologous oocyte-binding assay was used. Therefore, cryopreserved stallion sperm was co-incubated with porcine oocytes in capacitation as well as control-medium, after which nuclei were stained and the number of sperm per oocyte/zona was counted. Sperm-oocyte binding was determined to be higher in capacitation than in control medium, and if using diluted versus cryopreserved sperm. Furthermore, the number of sperm bound per oocyte was not negatively affected if cryopreserved sperm was subjected to dilution and 1 d cooled storage after thawing, suggesting that fertilizing capacity was maintained. (3) Finally, an insemination trial was performed to determine mare pregnancy rates using cryopreserved stallion sperm directly after thawing as well as after 24−36 h cooled storage after thawing. In addition, different insemination regimes were tested, including insemination after a defined duration after hCG-administration as well as maximally 6 h after ovulation (i.e. determined according to ultrasound ovulation controls). The insemination trial revealed that pregnancy rates achieved with using cryopreserved sperm after thawing and 1 d cooled storage (13/25, 52%) were not significantly different from when using freshly thawed sperm (7/10, 70%), nor were pregnancy rates negatively affected if insemination was planned according to the moment of hCG application instead of ovulation controls. Taken together, viability and fertilizing capacity of cryopreserved stallion semen is not negatively affected if stored at 4°C for up to 24−36 h after thawing. Moreover, if used for artificial insemination, mare pregnancy rates are similar as those obtained with using freshly thawed sperm.', 'Der Einsatz von Tiefgefriersamen in der modernen Pferdezucht nimmt zu, ist jedoch im Vergleich zu Frisch- und Kühlsamen mit höheren Kosten und geringeren Trächtigkeitsraten verbunden. Ursachen dafür sind, dass für die Verwendung von Tiefgefriersamen eine spezielle Ausrüstung für Transport, Lagerung und Besamung benötigt wird und eine Besamung nah am Zeitpunkt der Ovulation erfolgen muss. Das Ziel der in dieser Arbeit beschriebenen Studien war herauszufinden, ob Tiefgefriersamen seine Fertilisationsfähigkeit nach Auftauen und gekühltem Transport über Nacht (also 24 Stunden Lagerung bei 4°C) erhält. Außerdem wurde getestet, ob eine Besamung zu definierten Zeitpunkten nach hCG-Applikation genauso effektiv ist wie eine Besamung nah am Zeitpunkt der Ovulation (nach Ultraschallkontrolle alle 6 Stunden). Dieses Vorgehen würde Kosten reduzieren und Tiefgefriersamen einer breiteren Masse an Züchtern und Praktikern zugänglich machen. Diese Studie besteht aus drei Teilen: (1) als erstes wurde die Viabilität von Tiefgefriersamen in vitro bestimmt; direkt nach dem Auftauen, nach Verdünnung mit verschiedenen Verdünnern und nach einer 24-stündigen Lagerung bei 4°C. Der Samen wurde nach Auftauen und Verdünnung in einer Spritze in einer Polystyrol-Kühlbox bei 4°C wie Kühlsamen gelagert. Die Plasma- und Akrosommembranintegrität wurde durch flowzytometrische Messungen bestimmt, die Motilität und Bewegungsmuster der Spermien mittels Computer assistierter Spermienanalyse (CASA). Es wurden nur geringe Unterschiede membranintakter Spermien zwischen direkt nach dem Auftauen und nach 24 Stunden gekühlter Lagerung gefunden, unabhängig vom verwendeten Verdünner. Außerdem waren die Anteile progressiv motiler Spermien nur 3-8% niedriger nach 24 Stunden gekühlter Lagerung. (2) Zur Bestimmung der Fertilisationsfähigkeit kryokonservierter Spermien in vitro wurden heterologe Oozyten-Bindungsassays durchgeführt. Kryokonservierte equine Spermien wurden mit porcinen Oozyten in Kapazitations- und Kontrollmedium koinkubiert, anschließend wurden die Zellkerne angefärbt und die Anzahl der gebundenen Spermen pro Oozyte bestimmt. Die Spermien-Oozyten-Bindung ist höher in Kapazitäts- als in Kontrollmedium und höher bei Verwendung verdünnter versus kryokonservierter Spermien. Außerdem wird die Anzahl gebundener Spermien nicht negativ beeinflusst durch die Verdünnung und gekühlte Lagerung von kryokonservierten Spermien nach dem Auftauen für 24h, was darauf schließen lässt, dass die Fertilisationsfähigkeit erhalten bleibt. (3) Schließlich wurde ein Besamungsversuch durchgeführt zur Bestimmung der Trächtigkeitsraten von Stuten unter Verwendung kryokonservierter Spermien direkt nach dem Auftauen sowie nach 24-36 Stunden gekühlter Lagerung nach dem Auftauen. Es wurden verschiedene Besamungsregimes verglichen, einschließlich Besamung nach einer definierten Zeit nach hCG-Applikation, sowie maximal 6 Stunden nach Ovulation, welche per Ultraschallkontrolle bestimmt wurde. Der Besamungsversuch zeigte, dass Trächtigkeitsraten weder bei Nutzung von kryokonservierten Spermien nach Auftauen und 24 Stunden Lagerung (12/22, 59%) signifikant niedriger sind als bei Nutzung von frisch aufgetautem Sperma (7/10, 70%) noch bei Planung von Besamungen anhand des Zeitpunkts der Applikation von hCG anstatt per Ovulationskontrolle. Zusammengefasst ist die Viabilität und Fertilisationskapazität von kryokonservierten Spermien nicht negativ beeinflusst nach Lagerung für 24-36 Stunden bei 4°C nach dem Auftauen. Bei Verwendung dieser Spermien für die Besamung sind die Trächtigkeitsraten von Stuten ähnlich wie bei Verwendung von frisch aufgetautem Samen.']] | ['2018'] | ['http://id.loc.gov/vocabulary/iso639-1/en'] | ['open access'] | [[{'@id': 'gnd:4114638-4'}, {'@id': 'gnd:4024379-5'}, {'@id': 'gnd:4231333-8'}, {'@id': 'gnd:4156264-1'}, {'@id': 'gnd:4135383-3'}]] | ['gnd:4024379-5', 'gnd:4114638-4', 'gnd:4135383-3', 'gnd:4156264-1', 'gnd:4231333-8', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1049235541'] | ['Hengst', 'Motilität', 'Spermium', 'Gefriertrocknung', 'Fertilitätsdiagnostik'] | 10 |
3A1049242084.jsonld | {
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"sameAs": "Acetylcholin"
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"Hildebrandt, Herbert",
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"creator": "Meller, Sebastian",
"identifier": [
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"subject": [
"Temporallappen-Epilepsie",
"(classificationName=ddc)616.85",
"Neurotransmitter",
"Acetylcholine",
"Epilepsie",
"Acetylcholin",
"Aminos\u00e4uren",
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"title": "Die Rolle des zentralen cholinergen Systems und weiterer Neurotransmitter in Nagermodellen der Temporallappenepilepsie",
"abstract": [
"Epilepsy is one of the most common chronic neurological diseases of the central nervous system in humans and animals. Despite the development of various new antiepileptic drugs in the last few decades, obstacles to effective epilepsy treatment remain, including pharmacoresistance in more than 30 % of human patients and 50 % of dog patients as well as pronounced side effects. An antiepileptogenic therapy that suppress epilepsy development itself before the onset of spontaneous recurrent seizures would be preferable to the uncertain outcomes of symptomatic and lifelong therapy with antiepileptic drugs. Since epileptogenic processes remain barely understood, antiepileptogenic therapies are not feasible and, therefore, constitute one of the most important fields of current epilepsy research. In this context, there has so far been little research on the central cholinergic system compared to the excitatory glutamatergic and inhibitory GABAergic system. Nevertheless, recent studies have shown that an enhanced cholinergic signal is not only important for the induction and possibly maintenance of seizures, but also could bear epileptogenic properties. The goal of my work consisted of monitoring and characterizing extracellular levels of acetylcholine (ACh) in the hippocampus of rats between the initial brain insult leading to epilepsy and the chronic phase of epilepsy. Two different post-status epilepticus (SE) models of acquired temporal lobe epilepsy were used to assess model-specific differences: the chemical lithium-pilocarpine model and the prolonged electrical stimulation of the basolateral amygdala (BLA) model. The neurotransmitter ACh was sampled via microdialysis in the hippocampus of rats and analyzed via high performance liquid chromatography. We also sought to create a basic concept for strategies of antiepileptogenic therapies, e.g. by the antimuscarinic drug scopolamine. Furthermore, amino acid neurotransmitters like g-Aminobutyric acid (GABA), glutamate, aspartate, serine, glycine, and glutamine were analyzed to assess other neurochemical changes during epilepsy development. Extracellular levels of ACh in the dialysates rose significantly in comparison to control animals during SE in the lithium-pilocarpine model. For the first time, we were able to determine a similar (albeit lower) rise in ACh levels in the BLA model. During epileptogenesis and chronic epilepsy, no changes were observed in both models. However, ACh values in chronic epileptic animals were significantly lower than in animals in which spontaneous recurrent seizures were not detected. Though GABA and glutamate remained unchanged during SE in the chemical model, a significant rise of the concentrations of both neurotransmitters was detected in comparison to control values in the electrical model, persisting even after termination of SE. In the electrical model, glutamate levels also rose during the chronic epileptic phase. In the chemical model, there was a significant transient rise of GABA levels in nonepileptic animals in comparison to epileptic animals during the phase of epileptogenesis whereas glutamate levels of epileptic animals were significantly lower compared to control values in the chronic epileptic phase. This work allowed the first overview of extracellular ACh levels in two models of temporal lobe epilepsy in the rat hippocampus from induction of SE to the chronic epileptic phase. The extracellular rise in ACh concentrations during SE could imply its role in mechanisms of generating, maintaining, and possibly even inhibiting SE regardless of stimulus type. In contrast, GABA and glutamate seem to be more model-specific. Interestingly, values of GABA were partly increased in nonepileptic animals during the latent period. This increase could represent an attempt of the brain to prevent epileptogenic processes. Furthermore, the grade of ACh liberation seems to be positively correlated to the intensity of the SE. However, because changes of ACh levels were not seen in epileptogenesis or the chronic epileptic phase, it is questionable if ACh has epileptogenic properties. Nevertheless, hypersensitivity of the hippocampal tissue to ACh in early epileptogenesis could increase its putative epileptogenic potential. Besides, ACh release seems to be reduced in epileptic animals in the chronic epileptic phase. This reduction of ACh levels could represent a compensation mechanism. Hence, the use of cholinergic antagonists as an interesting approach for antiepileptogenic therapies could not be ruled out.",
"Epilepsien geh\u00f6ren zu den h\u00e4ufigsten chronischen neurologischen Erkrankungen des zentralen Nervensystems bei Mensch und Tier. Trotz der Entwicklung zahlreicher neuer Antiepileptika in den letzten Jahrzehnten stellen eine persistierende Pharmakoresistenz von mehr als 30 % beim Menschen und sogar mehr als 50 % beim Hund sowie Nebenwirkungen weiterhin ein gro\u00dfes Problem dar. Einer solchen lediglich symptomatischen und lebenslangen Behandlung mit ungewissem Erfolg w\u00e4re eine transiente antiepileptogene Therapie zur Unterdr\u00fcckung der Epilepsieentstehung in der Latenzzeit zwischen Hirninsult und dem Auftreten erster spontaner Anf\u00e4lle vorzuziehen. Da epileptogene Prozesse bis dato jedoch kaum verstanden sind, ist eine antiepileptogene Therapie nicht m\u00f6glich und stellt einen der aktuell wichtigsten Forschungsaspekte in der Epileptologie dar. Das zentrale cholinerge System stellt in diesem Zusammenhang ein bisher wenig erforschtes neurochemisches Netzwerk dar, da es zu Gunsten vom wichtigsten erregenden Neurotransmitter Glutamat und wichtigsten hemmenden Neurotransmitter g-Aminobutters\u00e4ure (GABA) in den Hintergrund geriet. Nichtsdestotrotz zeigten diverse Studien in j\u00fcngerer Vergangenheit, dass ein verst\u00e4rktes cholinerges Signal nicht nur f\u00fcr die Induktion und wom\u00f6glich f\u00fcr die Aufrechterhaltung von Anf\u00e4llen wichtig ist, sondern auch ein epileptogenes Potential bergen k\u00f6nnte. Das Ziel meiner Arbeit bestand darin, die extrazellul\u00e4re Konzentration von Acetylcholin (ACh) im Hippokampus von Ratten zwischen initialem Hirninsult und chronischer Epilepsie zu untersuchen und zu charakterisieren. Zur \u00dcberpr\u00fcfung modellspezifischer Abh\u00e4ngigkeiten neurochemischer Ver\u00e4nderungen wurden zwei Post-Status epilepticus (SE)-Modelle der Temporallappenepilepsie (TLE) miteinander verglichen: Das chemische Lithium (Li)-Pilocarpin-Modell und die langanhaltende elektrische Stimulation der basolateralen Amygdala (BLA-Modell). ACh wurde \u00fcber Mikrodialyse im Hippokampus gesammelt und anschlie\u00dfend per Hochleistungsfl\u00fcssigkeitschromatographie analysiert. Das weiterf\u00fchrende Ziel dieser Arbeit war es, mit den gewonnenen Daten den Weg f\u00fcr k\u00fcnftige Strategien zu Studien zur Antiepileptogenese durch Einsatz anticholinerger Substanzen wie z.B. Scopolamin zu ebnen. Zus\u00e4tzlich wurden Neurotransmitter aus der Klasse der Aminos\u00e4uren untersucht, um weitere neurochemische Ver\u00e4nderungen in der Epilepsieentwicklung festzustellen. ACh stieg in den Dialysaten w\u00e4hrend eines SE im Vergleich zu Kontrolltieren im chemischen Li-Pilocarpin-Modell signifikant an. Eine \u00e4hnliche Entwicklung konnten wir zum ersten Mal im elektrischen BLA-Modell nachweisen, die jedoch schw\u00e4cher ausgepr\u00e4gt war. In der Epileptogenese und Epilepsie konnten keine Ver\u00e4nderungen zwischen den Gruppen bei beiden Modellen festgestellt werden. Allerdings waren ACh-Werte bei chronisch epileptisch erkrankten Tieren signifikant niedriger als bei Tieren, bei denen keine spontanen Anf\u00e4lle detektiert wurden. W\u00e4hrend im chemischen Modell sowohl GABA als auch Glutamat im SE nicht erh\u00f6ht waren, kam es im elektrischen Modell zu einer signifikanten Erh\u00f6hung beider Transmitter gegen\u00fcber Kontrollwerten, die z.T. noch nach SE anhielt. In letzterem Modell war Glutamat auch in der chronisch epileptischen Phase erh\u00f6ht. Im chemischen Modell waren GABA-Werte in der Epileptogenese zeitweise bei Tieren ohne detektierte Anf\u00e4lle signifikant h\u00f6her als bei epileptischen Tieren, Glutamat-Werte hingegen in der epileptischen Phase bei epileptischen Tieren niedriger im Vergleich zu Kontrollwerten. Die Arbeit erm\u00f6glichte zum ersten Mal einen \u00dcberblick \u00fcber den extrazellul\u00e4ren Transmitterhaushalt des ACh im Hippokampus der Ratte von der Induktion des SE bis zur chronisch epileptischen Phase in zwei Modellen der TLE. Sein extrazellul\u00e4rer Konzentrationsanstieg w\u00e4hrend eines Anfalls spricht daf\u00fcr, dass ACh eine Rolle in anfallsgenerierenden, -erhaltenden und wom\u00f6glich sogar -hemmenden Mechanismen spielen k\u00f6nnte, die unabh\u00e4ngig von der Art des verwendeten Stimulus zu sein scheinen. Die Aussch\u00fcttung von GABA und Glutamat scheint hingegen modellspezifisch zu sein. Interessant ist hierbei, dass bei nicht-epileptischen Tieren GABA in der Latenzzeit z.T. erh\u00f6ht war, was f\u00fcr einen Reparationsmechanismus sprechen k\u00f6nnte. Weiterhin ist die ausgesch\u00fcttete ACh-Menge anscheinend abh\u00e4ngig von der Intensit\u00e4t des SE. W\u00e4hrend Epileptogenese und Epilepsie konnten jedoch keine Ver\u00e4nderungen in der ACh-Konzentration festgestellt werden. Ob ACh daher einen direkt proepileptogenen Faktor darstellt bleibt fragw\u00fcrdig. Eine in der Epileptogenese entstehende Hypersensitivit\u00e4t des hippokampalen Gewebes gegen\u00fcber ACh k\u00f6nnte sein vermeintliches epileptogenes Potential jedoch erh\u00f6hen. Au\u00dferdem scheint die ACh-Aussch\u00fcttung bei epileptisch erkrankten Tieren reduziert zu sein, was f\u00fcr potentielle Kompensationsmechanismen spricht. Es ist daher nicht auszuschlie\u00dfen, dass cholinerge Antagonisten einen interessanten Ansatz f\u00fcr antiepileptogene Therapien darstellen."
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} | ['gnd:4642127-0', 'gnd:4140660-6', 'gnd:4141256-4', 'gnd:4015035-5', 'gnd:4177011-0'] | ['Epilepsie', 'Tiermodell', 'Acetylcholin', 'Ratte', 'Hippocampus'] | ['meda'] | [['Pnimaskin, Evgeni', 'Hildebrandt, Herbert', 'Löscher, Wolfgang']] | [['(ppn)1049242084', '(firstid)GBV:1049242084']] | [''] | [['Temporallappen-Epilepsie', '(classificationName=ddc)616.85', 'Neurotransmitter', 'Acetylcholine', 'Epilepsie', 'Acetylcholin', 'Aminosäuren', '(classificationName=linseach:mapping)meda', '(classificationName=bk, id=106409980)44.90 - Neurologie', '(classificationName=ddc-dbn)630', 'Pilocarpin', 'Epilepsy', 'Amino acids', '(classificationName=ddc-dbn)610']] | ['Die Rolle des zentralen cholinergen Systems und weiterer Neurotransmitter in Nagermodellen der Temporallappenepilepsie'] | [['Epilepsy is one of the most common chronic neurological diseases of the central nervous system in humans and animals. Despite the development of various new antiepileptic drugs in the last few decades, obstacles to effective epilepsy treatment remain, including pharmacoresistance in more than 30 % of human patients and 50 % of dog patients as well as pronounced side effects. An antiepileptogenic therapy that suppress epilepsy development itself before the onset of spontaneous recurrent seizures would be preferable to the uncertain outcomes of symptomatic and lifelong therapy with antiepileptic drugs. Since epileptogenic processes remain barely understood, antiepileptogenic therapies are not feasible and, therefore, constitute one of the most important fields of current epilepsy research. In this context, there has so far been little research on the central cholinergic system compared to the excitatory glutamatergic and inhibitory GABAergic system. Nevertheless, recent studies have shown that an enhanced cholinergic signal is not only important for the induction and possibly maintenance of seizures, but also could bear epileptogenic properties. The goal of my work consisted of monitoring and characterizing extracellular levels of acetylcholine (ACh) in the hippocampus of rats between the initial brain insult leading to epilepsy and the chronic phase of epilepsy. Two different post-status epilepticus (SE) models of acquired temporal lobe epilepsy were used to assess model-specific differences: the chemical lithium-pilocarpine model and the prolonged electrical stimulation of the basolateral amygdala (BLA) model. The neurotransmitter ACh was sampled via microdialysis in the hippocampus of rats and analyzed via high performance liquid chromatography. We also sought to create a basic concept for strategies of antiepileptogenic therapies, e.g. by the antimuscarinic drug scopolamine. Furthermore, amino acid neurotransmitters like g-Aminobutyric acid (GABA), glutamate, aspartate, serine, glycine, and glutamine were analyzed to assess other neurochemical changes during epilepsy development. Extracellular levels of ACh in the dialysates rose significantly in comparison to control animals during SE in the lithium-pilocarpine model. For the first time, we were able to determine a similar (albeit lower) rise in ACh levels in the BLA model. During epileptogenesis and chronic epilepsy, no changes were observed in both models. However, ACh values in chronic epileptic animals were significantly lower than in animals in which spontaneous recurrent seizures were not detected. Though GABA and glutamate remained unchanged during SE in the chemical model, a significant rise of the concentrations of both neurotransmitters was detected in comparison to control values in the electrical model, persisting even after termination of SE. In the electrical model, glutamate levels also rose during the chronic epileptic phase. In the chemical model, there was a significant transient rise of GABA levels in nonepileptic animals in comparison to epileptic animals during the phase of epileptogenesis whereas glutamate levels of epileptic animals were significantly lower compared to control values in the chronic epileptic phase. This work allowed the first overview of extracellular ACh levels in two models of temporal lobe epilepsy in the rat hippocampus from induction of SE to the chronic epileptic phase. The extracellular rise in ACh concentrations during SE could imply its role in mechanisms of generating, maintaining, and possibly even inhibiting SE regardless of stimulus type. In contrast, GABA and glutamate seem to be more model-specific. Interestingly, values of GABA were partly increased in nonepileptic animals during the latent period. This increase could represent an attempt of the brain to prevent epileptogenic processes. Furthermore, the grade of ACh liberation seems to be positively correlated to the intensity of the SE. However, because changes of ACh levels were not seen in epileptogenesis or the chronic epileptic phase, it is questionable if ACh has epileptogenic properties. Nevertheless, hypersensitivity of the hippocampal tissue to ACh in early epileptogenesis could increase its putative epileptogenic potential. Besides, ACh release seems to be reduced in epileptic animals in the chronic epileptic phase. This reduction of ACh levels could represent a compensation mechanism. Hence, the use of cholinergic antagonists as an interesting approach for antiepileptogenic therapies could not be ruled out.', 'Epilepsien gehören zu den häufigsten chronischen neurologischen Erkrankungen des zentralen Nervensystems bei Mensch und Tier. Trotz der Entwicklung zahlreicher neuer Antiepileptika in den letzten Jahrzehnten stellen eine persistierende Pharmakoresistenz von mehr als 30 % beim Menschen und sogar mehr als 50 % beim Hund sowie Nebenwirkungen weiterhin ein großes Problem dar. Einer solchen lediglich symptomatischen und lebenslangen Behandlung mit ungewissem Erfolg wäre eine transiente antiepileptogene Therapie zur Unterdrückung der Epilepsieentstehung in der Latenzzeit zwischen Hirninsult und dem Auftreten erster spontaner Anfälle vorzuziehen. Da epileptogene Prozesse bis dato jedoch kaum verstanden sind, ist eine antiepileptogene Therapie nicht möglich und stellt einen der aktuell wichtigsten Forschungsaspekte in der Epileptologie dar. Das zentrale cholinerge System stellt in diesem Zusammenhang ein bisher wenig erforschtes neurochemisches Netzwerk dar, da es zu Gunsten vom wichtigsten erregenden Neurotransmitter Glutamat und wichtigsten hemmenden Neurotransmitter g-Aminobuttersäure (GABA) in den Hintergrund geriet. Nichtsdestotrotz zeigten diverse Studien in jüngerer Vergangenheit, dass ein verstärktes cholinerges Signal nicht nur für die Induktion und womöglich für die Aufrechterhaltung von Anfällen wichtig ist, sondern auch ein epileptogenes Potential bergen könnte. Das Ziel meiner Arbeit bestand darin, die extrazelluläre Konzentration von Acetylcholin (ACh) im Hippokampus von Ratten zwischen initialem Hirninsult und chronischer Epilepsie zu untersuchen und zu charakterisieren. Zur Überprüfung modellspezifischer Abhängigkeiten neurochemischer Veränderungen wurden zwei Post-Status epilepticus (SE)-Modelle der Temporallappenepilepsie (TLE) miteinander verglichen: Das chemische Lithium (Li)-Pilocarpin-Modell und die langanhaltende elektrische Stimulation der basolateralen Amygdala (BLA-Modell). ACh wurde über Mikrodialyse im Hippokampus gesammelt und anschließend per Hochleistungsflüssigkeitschromatographie analysiert. Das weiterführende Ziel dieser Arbeit war es, mit den gewonnenen Daten den Weg für künftige Strategien zu Studien zur Antiepileptogenese durch Einsatz anticholinerger Substanzen wie z.B. Scopolamin zu ebnen. Zusätzlich wurden Neurotransmitter aus der Klasse der Aminosäuren untersucht, um weitere neurochemische Veränderungen in der Epilepsieentwicklung festzustellen. ACh stieg in den Dialysaten während eines SE im Vergleich zu Kontrolltieren im chemischen Li-Pilocarpin-Modell signifikant an. Eine ähnliche Entwicklung konnten wir zum ersten Mal im elektrischen BLA-Modell nachweisen, die jedoch schwächer ausgeprägt war. In der Epileptogenese und Epilepsie konnten keine Veränderungen zwischen den Gruppen bei beiden Modellen festgestellt werden. Allerdings waren ACh-Werte bei chronisch epileptisch erkrankten Tieren signifikant niedriger als bei Tieren, bei denen keine spontanen Anfälle detektiert wurden. Während im chemischen Modell sowohl GABA als auch Glutamat im SE nicht erhöht waren, kam es im elektrischen Modell zu einer signifikanten Erhöhung beider Transmitter gegenüber Kontrollwerten, die z.T. noch nach SE anhielt. In letzterem Modell war Glutamat auch in der chronisch epileptischen Phase erhöht. Im chemischen Modell waren GABA-Werte in der Epileptogenese zeitweise bei Tieren ohne detektierte Anfälle signifikant höher als bei epileptischen Tieren, Glutamat-Werte hingegen in der epileptischen Phase bei epileptischen Tieren niedriger im Vergleich zu Kontrollwerten. Die Arbeit ermöglichte zum ersten Mal einen Überblick über den extrazellulären Transmitterhaushalt des ACh im Hippokampus der Ratte von der Induktion des SE bis zur chronisch epileptischen Phase in zwei Modellen der TLE. Sein extrazellulärer Konzentrationsanstieg während eines Anfalls spricht dafür, dass ACh eine Rolle in anfallsgenerierenden, -erhaltenden und womöglich sogar -hemmenden Mechanismen spielen könnte, die unabhängig von der Art des verwendeten Stimulus zu sein scheinen. Die Ausschüttung von GABA und Glutamat scheint hingegen modellspezifisch zu sein. Interessant ist hierbei, dass bei nicht-epileptischen Tieren GABA in der Latenzzeit z.T. erhöht war, was für einen Reparationsmechanismus sprechen könnte. Weiterhin ist die ausgeschüttete ACh-Menge anscheinend abhängig von der Intensität des SE. Während Epileptogenese und Epilepsie konnten jedoch keine Veränderungen in der ACh-Konzentration festgestellt werden. Ob ACh daher einen direkt proepileptogenen Faktor darstellt bleibt fragwürdig. Eine in der Epileptogenese entstehende Hypersensitivität des hippokampalen Gewebes gegenüber ACh könnte sein vermeintliches epileptogenes Potential jedoch erhöhen. Außerdem scheint die ACh-Ausschüttung bei epileptisch erkrankten Tieren reduziert zu sein, was für potentielle Kompensationsmechanismen spricht. Es ist daher nicht auszuschließen, dass cholinerge Antagonisten einen interessanten Ansatz für antiepileptogene Therapien darstellen.']] | ['2018'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4642127-0'}, {'@id': 'gnd:4140660-6'}, {'@id': 'gnd:4141256-4'}, {'@id': 'gnd:4015035-5'}, {'@id': 'gnd:4177011-0'}]] | ['gnd:4015035-5', 'gnd:4140660-6', 'gnd:4141256-4', 'gnd:4177011-0', 'gnd:4642127-0', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1049242084'] | ['Epilepsie', 'Tiermodell', 'Acetylcholin', 'Ratte', 'Hippocampus'] | 18 |
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"The Clinical Skills Lab (CSL) was set up in 2013 within the framework of the FERTHIK project at the University of Veterinary Medicine Hannover, Foundation (TiHo). Here, veterinary students can learn and practice practical skills in a realistic environment. For this purpose, students are introduced to the skills in learning stations using simulators and models. In order to improve the preparation for the learning stations, video tutorials are continuously being prepared and uploaded to the university's own YouTube channel \"TiHoVideos\". The AMeViTH project established lecture recordings at the TiHo. With fixed as well as mobile technology, it is possible to record lectures. The lectures are made available for students online in the password-protected university portal and used in addition to the on-site lecture. Aims of this work were the analysis of usage as well as the evaluation of the video tutorials of the university-owned YouTube channel in connection with the completion of learning stations in the CSL by students of the TiHo. On the other hand, the attitudes and special requirements of TiHo students and lecturers regarding the implementation of lecture notes should be evaluated. The acceptance and use of the \"TiHoVideos\" by students of TiHo was analyzed using questionnaires and the method of observation. A total of 835 questionnaires were evaluated. In addition, usage data of the YouTube channel was analyzed. The results show a high awareness of the channel and further expandable usage data among the students of the TiHo. The \"TiHoVideos\" are seen as \"very helpful\" for learning support in preparation for completing learning stations in the CSL. Viewing the videos, despite good equipment with mobile devices takes place mainly at home and not mobile or on site. Educational videos are a suitable medium to help veterinary students learn practical skills. In addition, they have the potential to contribute to animal welfare in veterinary education through the optimized use of live animals. In order to collect the requirements of lecture recordings, guided focus group surveys were conducted by a total of 63 students of all semesters and 13 teachers, and supplemented with questionnaires and short telephone queries. The results make it clear that lecturers prefer to provide students with a short version of the lectures. Despite skepticism, the lecturers see added value in the new learning technology. The high acceptance of the students and the desire to expand the offer became clear. Both groups see advantages in providing lecture recordings in a password protected room. In conclusion, the provision of educational video material corresponds to contemporary teaching. Particularly in the higher education sector, the establishment of new methods can ideally be empirically researched and adapted to the needs of the field. The digitization of teaching offers opportunities for both students and lecturers and can contribute to further development of the curriculum. The use of educational video material has arrived as a digital learning technology in veterinary medicine and is now establishing itself. At TiHo, the insights gained from the two studies have already been used to further optimize veterinary teaching and to adapt the lecture recordings to the collected requirements.",
"An der Stiftung Tier\u00e4rztliche Hochschule Hannover (TiHo) konnte im Rahmen des Projektes FERTHIK im Jahr 2013 ein Zentrum f\u00fcr klinische Fertigkeiten \u2013 Clinical Skills Lab (CSL) errichtet werden. Hier k\u00f6nnen Studierende der Tiermedizin in realit\u00e4tsnaher Umgebung praktische Fertigkeiten erlernen und \u00fcben. Zu diesem Zweck werden den Studierenden die zu vermittelnden F\u00e4higkeiten in Lernstationen an Simulatoren und Modellen nahegebracht. Um die Vorbereitung auf die durchzuf\u00fchrenden Fertigkeiten zu verbessern, werden kontinuierlich Videoanleitungen zu den Lernstationen erstellt und auf den hochschuleigenen YouTube-Kanal \u201eTiHoVideos\u201c hochgeladen. Durch das Projekt AMeViTH wurden Vorlesungsaufzeichnungen an der TiHo etabliert. Mit festinstallierter sowie mobiler Technik ist es m\u00f6glich, Vorlesungen aufzuzeichnen und diese Studierenden erg\u00e4nzend zur Pr\u00e4senzveranstaltung online im passwortgesch\u00fctzten Hochschulportal zur Verf\u00fcgung zu stellen. Ziele dieser Arbeit waren zum einen die Analyse der Nutzung sowie die Bewertung der Videoanleitungen des hochschuleigenen YouTube-Kanals im Zusammenhang mit dem Absolvieren von Lernstationen im CSL durch Studierende der TiHo. Zum anderen sollten die Einstellungen und speziellen Anforderungen Studierender und Dozierender der TiHo bez\u00fcglich der Implementierung von Vorlesungsaufzeichnungen erhoben werden. Die Akzeptanz und Nutzung der \u201eTiHoVideos\u201c durch Studierende der TiHo wurde mittels Frageb\u00f6gen und durch die Methode der Beobachtung durchgef\u00fchrt. Insgesamt konnten 835 Frageb\u00f6gen ausgewertet werden. Erg\u00e4nzend wurden Nutzungsdaten des YouTube-Kanals analysiert. Die Ergebnisse zeigen einen hohen Bekanntheitsgrad des Kanals und weiter ausbauf\u00e4hige Nutzungsdaten unter den Studierenden der TiHo. Die \u201eTiHoVideos\u201c werden als \u201esehr hilfreich\u201c zur Lernunterst\u00fctzung in der Vorbereitung auf das Absolvieren von Lernstationen im CSL gesehen. Das Ansehen der Videos erfolgt trotz guter Ausstattung mit mobilen Endger\u00e4ten haupts\u00e4chlich zuhause und nicht mobil oder vor Ort. Lehrvideos stellen ein passendes Medium dar, Tiermedizinstudierenden das Erlernen praktischer Fertigkeiten zu erleichtern. Dar\u00fcber hinaus haben diese durch den optimierten Einsatz von lebenden Tieren das Potential einen Beitrag zum Tierschutz in der veterin\u00e4rmedizinischen Ausbildung zu leisten. Um die Anforderungen an Vorlesungsaufzeichnungen zu erheben, wurden leitfadengest\u00fctzte Fokusgruppenbefragungen von insgesamt 63 Studierenden aller Semester und 13 Dozierenden durchgef\u00fchrt und mit Frageb\u00f6gen und kurzen telefonischen Abfragen erg\u00e4nzt. In den Ergebnissen wird deutlich, dass Dozierende es vorziehen, den Studierenden eine Kurzversion der Vorlesungen zur Verf\u00fcgung zu stellen. Trotz Skepsis sehen die Dozierenden einen Mehrwert in der neuen Lerntechnologie. Deutlich wurden weiterhin eine hohe Akzeptanz der Studierenden und der Wunsch nach dem Ausbau des Angebotes. Beide Gruppen sehen einen Vorteil darin, Vorlesungsaufzeichnungen in einem passwortgesch\u00fctztem Raum zur Verf\u00fcgung zu stellen. \u00dcbergreifend zeigt sich, dass die Bereitstellung von Lehrvideomaterial einer zeitgem\u00e4\u00dfen Lehre entspricht. Insbesondere im Hochschulbereich kann das Etablieren neuer Methoden ideal empirisch beforscht und mit gewonnenen Erkenntnissen bedarfsgerecht angepasst werden. Die Digitalisierung der Lehre bietet Chancen f\u00fcr sowohl Studierende als auch Dozierende und kann zur Weiterentwicklung des Curriculums beitragen. Der Einsatz von Lehrvideomaterial ist als digitale Lerntechnologie in der Tiermedizin angekommen und etabliert. An der TiHo werden die in den beiden durchgef\u00fchrten Studien gewonnenen Erkenntnisse bereits angewendet, um die tiermedizinische Hochschuldidaktik weiter zu optimieren und das Vorlesungsaufzeichnungsangebot an die genannten Anforderungen anzupassen."
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} | ['gnd:4117405-7', 'gnd:4058197-4', 'gnd:4167177-6', 'gnd:7597411-3'] | ['Studienerfolg', 'Vorlesung', 'Lehrfilm', 'YouTube'] | ['rest'] | [['Ehlers, Jan P.', 'Tipold, Andrea']] | [['(ppn)104924897X', '(firstid)GBV:104924897X']] | [''] | [['Lehre', 'Student', 'distance education', 'tiermedizinische Ausbildung', 'veterinary education', '(classificationName=bk, id=106408828)46.04 - Ausbildung, Beruf, Organisationen', 'Video', 'Hochschule', 'Vorlesung', 'E-Learning', 'Tiermedizin', '(classificationName=ddc-dbn)630', '(classificationName=linseach:mapping)rest', 'Lehren']] | ['Der Einsatz von Videomaterial in der veterinärmedizinischen Lehre'] | [['The Clinical Skills Lab (CSL) was set up in 2013 within the framework of the FERTHIK project at the University of Veterinary Medicine Hannover, Foundation (TiHo). Here, veterinary students can learn and practice practical skills in a realistic environment. For this purpose, students are introduced to the skills in learning stations using simulators and models. In order to improve the preparation for the learning stations, video tutorials are continuously being prepared and uploaded to the university\'s own YouTube channel "TiHoVideos". The AMeViTH project established lecture recordings at the TiHo. With fixed as well as mobile technology, it is possible to record lectures. The lectures are made available for students online in the password-protected university portal and used in addition to the on-site lecture. Aims of this work were the analysis of usage as well as the evaluation of the video tutorials of the university-owned YouTube channel in connection with the completion of learning stations in the CSL by students of the TiHo. On the other hand, the attitudes and special requirements of TiHo students and lecturers regarding the implementation of lecture notes should be evaluated. The acceptance and use of the "TiHoVideos" by students of TiHo was analyzed using questionnaires and the method of observation. A total of 835 questionnaires were evaluated. In addition, usage data of the YouTube channel was analyzed. The results show a high awareness of the channel and further expandable usage data among the students of the TiHo. The "TiHoVideos" are seen as "very helpful" for learning support in preparation for completing learning stations in the CSL. Viewing the videos, despite good equipment with mobile devices takes place mainly at home and not mobile or on site. Educational videos are a suitable medium to help veterinary students learn practical skills. In addition, they have the potential to contribute to animal welfare in veterinary education through the optimized use of live animals. In order to collect the requirements of lecture recordings, guided focus group surveys were conducted by a total of 63 students of all semesters and 13 teachers, and supplemented with questionnaires and short telephone queries. The results make it clear that lecturers prefer to provide students with a short version of the lectures. Despite skepticism, the lecturers see added value in the new learning technology. The high acceptance of the students and the desire to expand the offer became clear. Both groups see advantages in providing lecture recordings in a password protected room. In conclusion, the provision of educational video material corresponds to contemporary teaching. Particularly in the higher education sector, the establishment of new methods can ideally be empirically researched and adapted to the needs of the field. The digitization of teaching offers opportunities for both students and lecturers and can contribute to further development of the curriculum. The use of educational video material has arrived as a digital learning technology in veterinary medicine and is now establishing itself. At TiHo, the insights gained from the two studies have already been used to further optimize veterinary teaching and to adapt the lecture recordings to the collected requirements.', 'An der Stiftung Tierärztliche Hochschule Hannover (TiHo) konnte im Rahmen des Projektes FERTHIK im Jahr 2013 ein Zentrum für klinische Fertigkeiten – Clinical Skills Lab (CSL) errichtet werden. Hier können Studierende der Tiermedizin in realitätsnaher Umgebung praktische Fertigkeiten erlernen und üben. Zu diesem Zweck werden den Studierenden die zu vermittelnden Fähigkeiten in Lernstationen an Simulatoren und Modellen nahegebracht. Um die Vorbereitung auf die durchzuführenden Fertigkeiten zu verbessern, werden kontinuierlich Videoanleitungen zu den Lernstationen erstellt und auf den hochschuleigenen YouTube-Kanal „TiHoVideos“ hochgeladen. Durch das Projekt AMeViTH wurden Vorlesungsaufzeichnungen an der TiHo etabliert. Mit festinstallierter sowie mobiler Technik ist es möglich, Vorlesungen aufzuzeichnen und diese Studierenden ergänzend zur Präsenzveranstaltung online im passwortgeschützten Hochschulportal zur Verfügung zu stellen. Ziele dieser Arbeit waren zum einen die Analyse der Nutzung sowie die Bewertung der Videoanleitungen des hochschuleigenen YouTube-Kanals im Zusammenhang mit dem Absolvieren von Lernstationen im CSL durch Studierende der TiHo. Zum anderen sollten die Einstellungen und speziellen Anforderungen Studierender und Dozierender der TiHo bezüglich der Implementierung von Vorlesungsaufzeichnungen erhoben werden. Die Akzeptanz und Nutzung der „TiHoVideos“ durch Studierende der TiHo wurde mittels Fragebögen und durch die Methode der Beobachtung durchgeführt. Insgesamt konnten 835 Fragebögen ausgewertet werden. Ergänzend wurden Nutzungsdaten des YouTube-Kanals analysiert. Die Ergebnisse zeigen einen hohen Bekanntheitsgrad des Kanals und weiter ausbaufähige Nutzungsdaten unter den Studierenden der TiHo. Die „TiHoVideos“ werden als „sehr hilfreich“ zur Lernunterstützung in der Vorbereitung auf das Absolvieren von Lernstationen im CSL gesehen. Das Ansehen der Videos erfolgt trotz guter Ausstattung mit mobilen Endgeräten hauptsächlich zuhause und nicht mobil oder vor Ort. Lehrvideos stellen ein passendes Medium dar, Tiermedizinstudierenden das Erlernen praktischer Fertigkeiten zu erleichtern. Darüber hinaus haben diese durch den optimierten Einsatz von lebenden Tieren das Potential einen Beitrag zum Tierschutz in der veterinärmedizinischen Ausbildung zu leisten. Um die Anforderungen an Vorlesungsaufzeichnungen zu erheben, wurden leitfadengestützte Fokusgruppenbefragungen von insgesamt 63 Studierenden aller Semester und 13 Dozierenden durchgeführt und mit Fragebögen und kurzen telefonischen Abfragen ergänzt. In den Ergebnissen wird deutlich, dass Dozierende es vorziehen, den Studierenden eine Kurzversion der Vorlesungen zur Verfügung zu stellen. Trotz Skepsis sehen die Dozierenden einen Mehrwert in der neuen Lerntechnologie. Deutlich wurden weiterhin eine hohe Akzeptanz der Studierenden und der Wunsch nach dem Ausbau des Angebotes. Beide Gruppen sehen einen Vorteil darin, Vorlesungsaufzeichnungen in einem passwortgeschütztem Raum zur Verfügung zu stellen. Übergreifend zeigt sich, dass die Bereitstellung von Lehrvideomaterial einer zeitgemäßen Lehre entspricht. Insbesondere im Hochschulbereich kann das Etablieren neuer Methoden ideal empirisch beforscht und mit gewonnenen Erkenntnissen bedarfsgerecht angepasst werden. Die Digitalisierung der Lehre bietet Chancen für sowohl Studierende als auch Dozierende und kann zur Weiterentwicklung des Curriculums beitragen. Der Einsatz von Lehrvideomaterial ist als digitale Lerntechnologie in der Tiermedizin angekommen und etabliert. An der TiHo werden die in den beiden durchgeführten Studien gewonnenen Erkenntnisse bereits angewendet, um die tiermedizinische Hochschuldidaktik weiter zu optimieren und das Vorlesungsaufzeichnungsangebot an die genannten Anforderungen anzupassen.']] | ['2018'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4117405-7'}, {'@id': 'gnd:4058197-4'}, {'@id': 'gnd:4167177-6'}, {'@id': 'gnd:7597411-3'}]] | ['gnd:4058197-4', 'gnd:4117405-7', 'gnd:4167177-6', 'gnd:7597411-3', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A104924897X'] | ['Studienerfolg', 'Vorlesung', 'Lehrfilm', 'YouTube'] | 24 |
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"The aim of the following thesis was to examine the effects of neutering dogs like urinary incontinence, hypothyroidism and orthopedic problems depending of their age, size, body weight and breed. For this purpose, 6686 questions have been evaluated. The data of 3497 female and 3189 male dogs have been analyzed. 56,1 percent of the bitches and 43,9 percent of the males were castrated. The dogs belonged to 205 different breeds. There has been a connection between the occurrence of urinary incontinence and the reproduction status, the size, the body weight and the breed of the dogs. There was no relationship between the occurrence of urinary incontinence and the early or late neutering in bitches and male dogs. In 11,2 percent of the spayed bitches and 4,7 percent of the castrated males occurred urinary incontinence. 245 of the female dogs with urinary incontinence, 93 percent were spayed and 7 percent intact. The neutered female dogs had a 9,7 times higher risk and the male dogs a 1,7 higher risk to suffer from urinary incontinence than intact dogs. 20,0 percent of the male dogs which had been castrated late, at an age over eight years suffered from urinary incontinence. In female dogs of a shoulder height of over 40 centimeters there had a 12,6 percent higher risk to suffer from urinary incontinence than in spayed bitches of a shoulder height of under 40 centimeters with only 5,4 percent of incidences of urinary incontinence. The risk of urinary incontinence in spayed female dogs increases with increasing seize of the dogs. Spayed female dogs of over 60 centimeters shoulder height suffered 9,8 more often from urinary incontinence than not spayed female dogs of the same height. Spayed female dogs with a weight of over 20 kilograms suffered 16 times more of urinary incontinence (14,4 percent) than not spayed females with 0,9 percent and a weight of over 20 kilograms. In the weight range \u201c20 to 30 kilograms body weight\u201d even 23,6 times as much spayed female dogs suffered from urinary incontinence than intact ones. Certain breed dispositions for urinary incontinence can be identified in spayed female dogs for the breeds Bull Terrier, Giant schnauzer and the Dogue de Bordeaux and for the breed groups pinscher and Schnauzer (25,9 percent), pointing dogs (19,2 percent) and Molossoid breeds (15,6 percent). For the evaluation of hypothyroidism as a side effect of neutering, 324 dogs were found who suffered from it. There has been a connection between the occurrence of hypothyroidism and the reproduction status, the age, the size, the body weight and the breed of the dogs. Castrated male dogs were 7,7 percent more often affected by the disease than spayed bitches with 5,5 percent. In every range of age, neutered male dogs and female dogs were more often affected by hypothyroidism than intact ones, except the group of males of the age between 9 and 12 years. The risk of hypothyroidism increased in bitches and male dogs with increasing age, size and body weight. A breed predisposition can be identified for the Rhodesian Ridgeback (21,8 percent), the Magyar Vizsla (16,6 percent) and the Dobermann (12,2 percent). For the evaluation of the orthopedic problems as the secondary effect of neutering, 1209 dogs were found who suffered from it. There has been a connection between the occurrence of orthopedic problems depending of the reproduction status and the breed of the dogs. The neutered female dogs hat a 3,0 times higher risk and the male dogs a 1,8 higher risk to suffer than intact dogs. Breed predispositions can be recognized in spayed bitches for the Swiss Mountain/Cattle Dogs (43,2 percent), for the Molossoid (38,3 percent) as well as for crossbreeds (31,2 percent) with a body weight above 20 kilograms. The recommendation can be made to castrate the male dog shortly after puberty, if a medical indication exists, because the risk of urinary incontinence increases to 20 percent for the late neutered dogs with increasing age. In view of the present results there can be made no recommendation for neutering of Giant Schnauzer, because 45,0 percent of the female dogs and 28,6 percent of the males of all neutered animals suffered from urinary incontinence. Summarizing the above, it can be stated that during the consultation the owner of the dog should be fully informed about possible unwanted side effects of the neutering. Advantages and disadvantages should be discussed and the reason for the neutering should be identified. The breed, the sex, the age and the body weight of the dog have to be taken into account. It remains a decision for the individual animal. Possible alternatives like the chemical castration via an injectable hormone implant (Suprelorin\u00ae) should as well be considered in case of neutering a male dog.",
"Ziel der vorliegenden Arbeit war es, die Kastrationsfolgen Harninkontinenz, Hypothyreose und Probleme mit dem Bewegungsapparat beim Hund in Abh\u00e4ngigkeit von Alter, Gr\u00f6\u00dfe, Gewicht und Rasse zu untersuchen. Dazu wurden 6686 Fragebogen ausgewertet. Es wurden Daten von 3497 H\u00fcndinnen und 3189 R\u00fcden analysiert. 56,1% der H\u00fcndinnen und 43,9 % der R\u00fcden waren kastriert. Die Hunde geh\u00f6rten 205 verschiedenen Rassen an. Es bestanden Zusammenh\u00e4nge zwischen dem Auftreten von Harninkontinenz und dem Reproduktionsstatus, der Gr\u00f6\u00dfe, dem Gewicht und Rasse der Hunde. Es bestand kein Zusammenhang zwischen dem Auftreten von Harninkontinenz und einer Fr\u00fch- oder Sp\u00e4tkastration bei H\u00fcndinnen und R\u00fcden. Bei 11,2 % der kastrierten H\u00fcndinnen und 4,7 % der kastrierten R\u00fcden trat Harninkontinenz auf. Von den 245 inkontinenten H\u00fcndinnen waren 93 % kastriert und 7 % intakt. Kastrierte H\u00fcndinnen hatten ein 9,7-fach und kastrierte R\u00fcden ein 1,7-fach erh\u00f6htes Risiko an Harninkontinenz zu erkranken als intakte Hunde. R\u00fcden welche mit \u00fcber acht Jahren sp\u00e4tkastriert wurden, zeigten zu 20,0 % Harntr\u00e4ufeln. H\u00fcndinnen \u00fcber 40 cm Schulterh\u00f6he hatten mit 12,6 % Erkrankungen ein 2,3-fach h\u00f6heres Risiko, an Harninkontinenz zu erkranken als kastrierte H\u00fcndinnen unter 40 cm Schulterh\u00f6he mit nur 5,4 % Erkrankungsf\u00e4llen. Das Risiko f\u00fcr kastrierte H\u00fcndinnen an Harninkontinenz zu erkranken, stieg mit zunehmender Gr\u00f6\u00dfe an. Kastrierte H\u00fcndinnen \u00fcber 60 cm Schulterh\u00f6he waren 9,8-mal h\u00e4ufiger erkrankt als intakte H\u00fcndinnen derselben Gr\u00f6\u00dfenklasse. Kastrierte H\u00fcndinnen \u00fcber 20 Kilogramm K\u00f6rpergewicht waren mit 14,4 % 16-mal h\u00e4ufiger erkrankt als intakte H\u00fcndinnen mit 0,9 % und einem K\u00f6rpergewicht \u00fcber 20 Kilogramm. In der Gewichtsklasse \u201e20 bis 30 Kilogramm K\u00f6rpergewicht\u201c waren sogar 23,6-mal so viele kastrierte H\u00fcndinnen an Harninkontinenz erkrankt als intakte. Rassedispositionen f\u00fcr Harninkontinenz lassen sich bei den kastrierten H\u00fcndinnen f\u00fcr die Einzelrassen Bull Terrier, Riesenschnauzer und Bordeauxdogge aussprechen und f\u00fcr die Rassegruppen der Pinscher und Schnauzer (25,9 %), Vorstehhunde (19,2 %) und Molosser (15,6 %). In die Auswertung der Kastrationsnebenwirkung Hypothyreose gingen 324 erkrankte Hunde ein. Es bestanden Zusammenh\u00e4nge zwischen dem Auftreten von Hypothyreose und dem Reproduktionsstatus, dem Alter, der Gr\u00f6\u00dfe, dem Gewicht und Rasse der Hunde. Kastrierte R\u00fcden waren mit 7,7 % h\u00e4ufiger als kastrierte H\u00fcndinnen mit 5,5 % Erkrankungsf\u00e4llen betroffen. Kastrierte R\u00fcden und H\u00fcndinnen erkrankten in jeder Altersklasse h\u00e4ufiger an Hypothyreose als intakte, mit Ausnahme der Gruppe der \u201e9 bis 12-j\u00e4hrigen R\u00fcden\u201c. Das Risiko f\u00fcr Hypothyreose stieg bei H\u00fcndinnen und R\u00fcden mit zunehmender Alter, Gr\u00f6\u00dfe und Gewicht an. Rassedispositionen k\u00f6nnen f\u00fcr den Rhodesian-Ridgeback (21,8 %), Magyar Vizsla (16,6 %) und Dobermann (12,2 %) ausgesprochen werden. F\u00fcr die Auswertung der Kastrationsnebenwirkung \"Probleme mit dem Bewegungsapparat\u201c gingen 1209 erkrankte Hunde ein. Es bestanden Zusammenh\u00e4nge zwischen dem Auftreten von Problemen mit dem Bewegungsapparat in Abh\u00e4ngigkeit vom Reproduktionsstatus und der Rasse der Hunde. Kastrierte H\u00fcndinnen hatten ein 3,0-fach und kastrierte R\u00fcden ein 1,8-fach erh\u00f6htes Risiko zu erkranken als intakte Hunde. Rassedispositionen lassen sich bei kastrierten H\u00fcndinnen f\u00fcr die Rassegruppe der Sennen- und Treibhunde (43,2 %), Molosser (38,3 %), sowie Mischlinge mit einem K\u00f6rpergewicht \u00fcber 20 Kilogramm (31,2 %) feststellen. Es kann die Empfehlung ausgesprochen werden, R\u00fcden m\u00f6glichst fr\u00fchzeitig nach der Pubert\u00e4t kastrieren zu lassen, wenn eine medizinische Indikation vorliegt, da das Risiko der Sp\u00e4tkastrierten mit zunehmendem Alter f\u00fcr Harninkontinenz bis auf 20 % ansteigt. Im Hinblick auf die vorliegenden Ergebnisse kann keine Empfehlung der Kastration von Riesenschnauzern ausgesprochen werden, da die H\u00fcndinnen mit 45,0 % und R\u00fcden mit 28,6 % aller kastrierten Tiere von Harninkontinenz betroffen waren. Das Risiko f\u00fcr die Kastrationsfolgen Harninkontinenz, Hypothyreose und Probleme mit dem Bewegungsapparat war bei kastrierten Hunden im Gegensatz zu intakten erh\u00f6ht und stieg mit zunehmendem Gewicht, Gr\u00f6\u00dfe und Alter der Hunde an. Zusammenfassend bleibt festzustellen, dass bei der Kastrationsberatung f\u00fcr seinen Hund der Besitzer umfassend \u00fcber m\u00f6gliche unerw\u00fcnschte Nebenwirkungen aufgekl\u00e4rt werden muss. Vor- und Nachteile sollten besprochen werden und der Grund f\u00fcr die Kastration herausgearbeitet werden. Die Rasse, das Geschlecht, das Alter und das Gewicht des Hundes m\u00fcssen Ber\u00fccksichtigung finden. Es bleibt eine Einzeltierentscheidung. Ebenso sollte bei R\u00fcden \u00fcber die m\u00f6gliche Alternative der medikamentellen Kastration mittels Suprelorin\u00ae Implantat nachgedacht werden."
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} | ['gnd:4029906-5', 'gnd:4026181-5', 'gnd:4317914-9'] | ['Hund', 'Kastration', 'Nebenwirkung'] | ['rest'] | ['Technische Informationsbibliothek (TIB)'] | [['(ppn)1049262220', '(firstid)GBV:1049262220']] | [''] | [['Harninkontinenz', '(classificationName=bk, id=106419048)46.80 - Klinische Tiermedizin', 'Kastrationsfolgen', 'Rasse', '(classificationName=ddc-dbn)630', 'Bewegungsapparat', '(classificationName=linseach:mapping)rest', 'effects of neutering', 'Kastration', 'Hund', 'urinary incontinence', 'Rüde', 'Rasseprädisposition', 'breed disposition', 'Absolvent']] | ['Kastrationsfolgen beim Hund in Abhängigkeit von Alter, Größe, Gewicht und Rasse'] | [['The aim of the following thesis was to examine the effects of neutering dogs like urinary incontinence, hypothyroidism and orthopedic problems depending of their age, size, body weight and breed. For this purpose, 6686 questions have been evaluated. The data of 3497 female and 3189 male dogs have been analyzed. 56,1 percent of the bitches and 43,9 percent of the males were castrated. The dogs belonged to 205 different breeds. There has been a connection between the occurrence of urinary incontinence and the reproduction status, the size, the body weight and the breed of the dogs. There was no relationship between the occurrence of urinary incontinence and the early or late neutering in bitches and male dogs. In 11,2 percent of the spayed bitches and 4,7 percent of the castrated males occurred urinary incontinence. 245 of the female dogs with urinary incontinence, 93 percent were spayed and 7 percent intact. The neutered female dogs had a 9,7 times higher risk and the male dogs a 1,7 higher risk to suffer from urinary incontinence than intact dogs. 20,0 percent of the male dogs which had been castrated late, at an age over eight years suffered from urinary incontinence. In female dogs of a shoulder height of over 40 centimeters there had a 12,6 percent higher risk to suffer from urinary incontinence than in spayed bitches of a shoulder height of under 40 centimeters with only 5,4 percent of incidences of urinary incontinence. The risk of urinary incontinence in spayed female dogs increases with increasing seize of the dogs. Spayed female dogs of over 60 centimeters shoulder height suffered 9,8 more often from urinary incontinence than not spayed female dogs of the same height. Spayed female dogs with a weight of over 20 kilograms suffered 16 times more of urinary incontinence (14,4 percent) than not spayed females with 0,9 percent and a weight of over 20 kilograms. In the weight range “20 to 30 kilograms body weight” even 23,6 times as much spayed female dogs suffered from urinary incontinence than intact ones. Certain breed dispositions for urinary incontinence can be identified in spayed female dogs for the breeds Bull Terrier, Giant schnauzer and the Dogue de Bordeaux and for the breed groups pinscher and Schnauzer (25,9 percent), pointing dogs (19,2 percent) and Molossoid breeds (15,6 percent). For the evaluation of hypothyroidism as a side effect of neutering, 324 dogs were found who suffered from it. There has been a connection between the occurrence of hypothyroidism and the reproduction status, the age, the size, the body weight and the breed of the dogs. Castrated male dogs were 7,7 percent more often affected by the disease than spayed bitches with 5,5 percent. In every range of age, neutered male dogs and female dogs were more often affected by hypothyroidism than intact ones, except the group of males of the age between 9 and 12 years. The risk of hypothyroidism increased in bitches and male dogs with increasing age, size and body weight. A breed predisposition can be identified for the Rhodesian Ridgeback (21,8 percent), the Magyar Vizsla (16,6 percent) and the Dobermann (12,2 percent). For the evaluation of the orthopedic problems as the secondary effect of neutering, 1209 dogs were found who suffered from it. There has been a connection between the occurrence of orthopedic problems depending of the reproduction status and the breed of the dogs. The neutered female dogs hat a 3,0 times higher risk and the male dogs a 1,8 higher risk to suffer than intact dogs. Breed predispositions can be recognized in spayed bitches for the Swiss Mountain/Cattle Dogs (43,2 percent), for the Molossoid (38,3 percent) as well as for crossbreeds (31,2 percent) with a body weight above 20 kilograms. The recommendation can be made to castrate the male dog shortly after puberty, if a medical indication exists, because the risk of urinary incontinence increases to 20 percent for the late neutered dogs with increasing age. In view of the present results there can be made no recommendation for neutering of Giant Schnauzer, because 45,0 percent of the female dogs and 28,6 percent of the males of all neutered animals suffered from urinary incontinence. Summarizing the above, it can be stated that during the consultation the owner of the dog should be fully informed about possible unwanted side effects of the neutering. Advantages and disadvantages should be discussed and the reason for the neutering should be identified. The breed, the sex, the age and the body weight of the dog have to be taken into account. It remains a decision for the individual animal. Possible alternatives like the chemical castration via an injectable hormone implant (Suprelorin®) should as well be considered in case of neutering a male dog.', 'Ziel der vorliegenden Arbeit war es, die Kastrationsfolgen Harninkontinenz, Hypothyreose und Probleme mit dem Bewegungsapparat beim Hund in Abhängigkeit von Alter, Größe, Gewicht und Rasse zu untersuchen. Dazu wurden 6686 Fragebogen ausgewertet. Es wurden Daten von 3497 Hündinnen und 3189 Rüden analysiert. 56,1% der Hündinnen und 43,9 % der Rüden waren kastriert. Die Hunde gehörten 205 verschiedenen Rassen an. Es bestanden Zusammenhänge zwischen dem Auftreten von Harninkontinenz und dem Reproduktionsstatus, der Größe, dem Gewicht und Rasse der Hunde. Es bestand kein Zusammenhang zwischen dem Auftreten von Harninkontinenz und einer Früh- oder Spätkastration bei Hündinnen und Rüden. Bei 11,2 % der kastrierten Hündinnen und 4,7 % der kastrierten Rüden trat Harninkontinenz auf. Von den 245 inkontinenten Hündinnen waren 93 % kastriert und 7 % intakt. Kastrierte Hündinnen hatten ein 9,7-fach und kastrierte Rüden ein 1,7-fach erhöhtes Risiko an Harninkontinenz zu erkranken als intakte Hunde. Rüden welche mit über acht Jahren spätkastriert wurden, zeigten zu 20,0 % Harnträufeln. Hündinnen über 40 cm Schulterhöhe hatten mit 12,6 % Erkrankungen ein 2,3-fach höheres Risiko, an Harninkontinenz zu erkranken als kastrierte Hündinnen unter 40 cm Schulterhöhe mit nur 5,4 % Erkrankungsfällen. Das Risiko für kastrierte Hündinnen an Harninkontinenz zu erkranken, stieg mit zunehmender Größe an. Kastrierte Hündinnen über 60 cm Schulterhöhe waren 9,8-mal häufiger erkrankt als intakte Hündinnen derselben Größenklasse. Kastrierte Hündinnen über 20 Kilogramm Körpergewicht waren mit 14,4 % 16-mal häufiger erkrankt als intakte Hündinnen mit 0,9 % und einem Körpergewicht über 20 Kilogramm. In der Gewichtsklasse „20 bis 30 Kilogramm Körpergewicht“ waren sogar 23,6-mal so viele kastrierte Hündinnen an Harninkontinenz erkrankt als intakte. Rassedispositionen für Harninkontinenz lassen sich bei den kastrierten Hündinnen für die Einzelrassen Bull Terrier, Riesenschnauzer und Bordeauxdogge aussprechen und für die Rassegruppen der Pinscher und Schnauzer (25,9 %), Vorstehhunde (19,2 %) und Molosser (15,6 %). In die Auswertung der Kastrationsnebenwirkung Hypothyreose gingen 324 erkrankte Hunde ein. Es bestanden Zusammenhänge zwischen dem Auftreten von Hypothyreose und dem Reproduktionsstatus, dem Alter, der Größe, dem Gewicht und Rasse der Hunde. Kastrierte Rüden waren mit 7,7 % häufiger als kastrierte Hündinnen mit 5,5 % Erkrankungsfällen betroffen. Kastrierte Rüden und Hündinnen erkrankten in jeder Altersklasse häufiger an Hypothyreose als intakte, mit Ausnahme der Gruppe der „9 bis 12-jährigen Rüden“. Das Risiko für Hypothyreose stieg bei Hündinnen und Rüden mit zunehmender Alter, Größe und Gewicht an. Rassedispositionen können für den Rhodesian-Ridgeback (21,8 %), Magyar Vizsla (16,6 %) und Dobermann (12,2 %) ausgesprochen werden. Für die Auswertung der Kastrationsnebenwirkung "Probleme mit dem Bewegungsapparat“ gingen 1209 erkrankte Hunde ein. Es bestanden Zusammenhänge zwischen dem Auftreten von Problemen mit dem Bewegungsapparat in Abhängigkeit vom Reproduktionsstatus und der Rasse der Hunde. Kastrierte Hündinnen hatten ein 3,0-fach und kastrierte Rüden ein 1,8-fach erhöhtes Risiko zu erkranken als intakte Hunde. Rassedispositionen lassen sich bei kastrierten Hündinnen für die Rassegruppe der Sennen- und Treibhunde (43,2 %), Molosser (38,3 %), sowie Mischlinge mit einem Körpergewicht über 20 Kilogramm (31,2 %) feststellen. Es kann die Empfehlung ausgesprochen werden, Rüden möglichst frühzeitig nach der Pubertät kastrieren zu lassen, wenn eine medizinische Indikation vorliegt, da das Risiko der Spätkastrierten mit zunehmendem Alter für Harninkontinenz bis auf 20 % ansteigt. Im Hinblick auf die vorliegenden Ergebnisse kann keine Empfehlung der Kastration von Riesenschnauzern ausgesprochen werden, da die Hündinnen mit 45,0 % und Rüden mit 28,6 % aller kastrierten Tiere von Harninkontinenz betroffen waren. Das Risiko für die Kastrationsfolgen Harninkontinenz, Hypothyreose und Probleme mit dem Bewegungsapparat war bei kastrierten Hunden im Gegensatz zu intakten erhöht und stieg mit zunehmendem Gewicht, Größe und Alter der Hunde an. Zusammenfassend bleibt festzustellen, dass bei der Kastrationsberatung für seinen Hund der Besitzer umfassend über mögliche unerwünschte Nebenwirkungen aufgeklärt werden muss. Vor- und Nachteile sollten besprochen werden und der Grund für die Kastration herausgearbeitet werden. Die Rasse, das Geschlecht, das Alter und das Gewicht des Hundes müssen Berücksichtigung finden. Es bleibt eine Einzeltierentscheidung. Ebenso sollte bei Rüden über die mögliche Alternative der medikamentellen Kastration mittels Suprelorin® Implantat nachgedacht werden.']] | ['2018'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4029906-5'}, {'@id': 'gnd:4026181-5'}, {'@id': 'gnd:4317914-9'}]] | ['gnd:4026181-5', 'gnd:4029906-5', 'gnd:4317914-9', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1049262220'] | ['Hund', 'Kastration', 'Nebenwirkung'] | 24 |
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To specify the damage accumulation of FRP in the presence of voids, the complex three dimensional structure of the composite including several voids were analysed and a reduced mechanical model composite was derived. The reduced model consists of the matrix system and a unique void, which is squeezed between two fibres by using an injection method. The experimental investigation of the model composite included the description of the stress- and strain behaviour of the matrix using photoelasticity and digital image correlation technology. Additionally, a numerical examination of a parameterised model composite and an analytical study of the stability of a single fibre was conducted. As a result of the experimental investigation of the model composite consisting of ten fibres embedded in a matrix, the failure initiation and propagation could be observed. Supported by the findings from the numerical examination and the analytical study, the most impact on the failure initiation has the foundation of the fibre as well as the bonding between fibre and matrix. Both facts are leading to a premature fibre-matrix debonding with ongoing loss of stability of the fibre finally resulting in fibre kinking. Because of the rearrangement of stresses further overloaded fibres failed. Additional studies on transparent glassfibre reinforced polymers including a unique void showed, that the gained experience made on the examination of the model composite could be transferred to real existed composites.', 'Die vorliegende Arbeit befasst sich mit der Untersuchung des Einflusses von Poren auf die mechanischen Eigenschaften von Faser-Kunststoff-Verbunden (FKV) unter Drucklast. Um die Schadensentwicklung durch Poren in einem FKV näher be\\-schrei\\-ben zu können, wurde der komplexe dreidimensionale strukturelle Aufbau des Verbundes inklusive der Poren analysiert und dieser in einen vereinfachten modellhaften Verbund überführt. Der modellhafte Verbund besteht aus der Matrix und mindestens zwei Fasern, zwischen denen eine einzelne Pore platziert wurde. Neben der experimentellen Untersuchung des modellhaften Probekörpers, welche die Betrachtung des Spannungs- und Dehnungsverhaltens der Matrix mittels der optischen Spannungsanalyse und digitalen Bildkorrelation beinhaltet, wurde zusätzlich der Verbund mit Hilfe der Finite-Elemente-Methode numerisch in einem parametrisierten Modell abgebildet und das Stabilitätsverhalten einer Faser analytisch beschrieben. Insbesondere die experimentelle Untersuchung erlaubte es, bei der Verwendung von zehn Fasern im modellhaften Probekörper die Schadensentwicklung in der unmittelbaren Umgebung einer Pore schrittweise zu beobachten. Gestützt durch Erkenntnisse aus der numerischen und analytischen Betrachtung konnte festgestellt werden, dass sowohl die Art und Weise der Stützung der Faser durch die Matrix, als auch deren Haftung untereinander versagensrelevant sind. Beide Aspekte führen zu einer frühzeitigen longitudinalen Ablösung der Faser von der Matrix mit anschließendem Stabilitätsverlust der Faser durch deren Ausknicken. Dies ist Ursache für weitere Faserbrüche, die aufgrund der Lastumlagerung initiiert werden. Untersuchungen an einem transparenten glasfaserverstärkten Kunststoff mit einer einzeln eingebrachten Pore boten darüber hinaus die Möglichkeit, die Erkenntnisse aus den Versuchen mit dem modellhaften Probekörper auf anwendungsnahe faserverstärkte Kunststoffe zu transferieren.']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4352629-9'}, {'@id': 'gnd:4217961-0'}, {'@id': 'gnd:4131028-7'}, {'@id': 'gnd:4128805-1'}]] | ['gnd:10137194-9', 'gnd:1068356049', 'gnd:1133109063', 'gnd:1137579242', 'gnd:2067664-5', 'gnd:4128805-1', 'gnd:4131028-7', 'gnd:4217961-0', 'gnd:4352629-9', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1067410899'] | ['Technische Universität Hamburg-Harburg, Institut für Kunststoffe und Verbundwerkstoffe', 'Liebig, Wilfried V.', 'Hintze, Wolfgang', 'Schulte, Karl', 'Technische Universität Hamburg-Harburg', 'Faserverstärkter Kunststoff', 'Mikrostruktur', 'Mechanische Eigenschaft', 'Pore'] | 22 |
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Supported by the findings from the numerical examination and the analytical study, the most impact on the failure initiation has the foundation of the fibre as well as the bonding between fibre and matrix. Both facts are leading to a premature fibre-matrix debonding with ongoing loss of stability of the fibre finally resulting in fibre kinking. Because of the rearrangement of stresses further overloaded fibres failed. Additional studies on transparent glassfibre reinforced polymers including a unique void showed, that the gained experience made on the examination of the model composite could be transferred to real existed composites.', 'Die vorliegende Arbeit befasst sich mit der Untersuchung des Einflusses von Poren auf die mechanischen Eigenschaften von Faser-Kunststoff-Verbunden (FKV) unter Drucklast. Um die Schadensentwicklung durch Poren in einem FKV näher be\\-schrei\\-ben zu können, wurde der komplexe dreidimensionale strukturelle Aufbau des Verbundes inklusive der Poren analysiert und dieser in einen vereinfachten modellhaften Verbund überführt. Der modellhafte Verbund besteht aus der Matrix und mindestens zwei Fasern, zwischen denen eine einzelne Pore platziert wurde. Neben der experimentellen Untersuchung des modellhaften Probekörpers, welche die Betrachtung des Spannungs- und Dehnungsverhaltens der Matrix mittels der optischen Spannungsanalyse und digitalen Bildkorrelation beinhaltet, wurde zusätzlich der Verbund mit Hilfe der Finite-Elemente-Methode numerisch in einem parametrisierten Modell abgebildet und das Stabilitätsverhalten einer Faser analytisch beschrieben. Insbesondere die experimentelle Untersuchung erlaubte es, bei der Verwendung von zehn Fasern im modellhaften Probekörper die Schadensentwicklung in der unmittelbaren Umgebung einer Pore schrittweise zu beobachten. Gestützt durch Erkenntnisse aus der numerischen und analytischen Betrachtung konnte festgestellt werden, dass sowohl die Art und Weise der Stützung der Faser durch die Matrix, als auch deren Haftung untereinander versagensrelevant sind. Beide Aspekte führen zu einer frühzeitigen longitudinalen Ablösung der Faser von der Matrix mit anschließendem Stabilitätsverlust der Faser durch deren Ausknicken. Dies ist Ursache für weitere Faserbrüche, die aufgrund der Lastumlagerung initiiert werden. Untersuchungen an einem transparenten glasfaserverstärkten Kunststoff mit einer einzeln eingebrachten Pore boten darüber hinaus die Möglichkeit, die Erkenntnisse aus den Versuchen mit dem modellhaften Probekörper auf anwendungsnahe faserverstärkte Kunststoffe zu transferieren.']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4352629-9'}, {'@id': 'gnd:4217961-0'}, {'@id': 'gnd:4131028-7'}, {'@id': 'gnd:4128805-1'}]] | ['gnd:10137194-9', 'gnd:1068356049', 'gnd:1133109063', 'gnd:1137579242', 'gnd:2067664-5', 'gnd:4128805-1', 'gnd:4131028-7', 'gnd:4217961-0', 'gnd:4352629-9', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1067410899'] | ['Technische Universität Hamburg-Harburg, Institut für Kunststoffe und Verbundwerkstoffe', 'Liebig, Wilfried V.', 'Hintze, Wolfgang', 'Schulte, Karl', 'Technische Universität Hamburg-Harburg', 'Faserverstärkter Kunststoff', 'Mikrostruktur', 'Mechanische Eigenschaft', 'Pore'] | 7 |
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} | ['gnd:4439521-8', 'gnd:4546895-3', 'gnd:4116522-6', 'gnd:4396978-1', 'gnd:4113542-8', 'gnd:4464685-9'] | ['Fernüberwachung', 'Softwareentwicklung', 'Eingebettetes System', 'Komponente (Software)', 'Framework (Informatik)', 'Entwurfsmuster'] | ['tec'] | ['Technische Informationsbibliothek (TIB)'] | [['(isbn)3540431896', '(firstid)BSZ:322899990', '(isbn13)9783540457077', '(doi)10.1007/3-540-45707-0', '(isbn13)9783540431893', '(ppn)1649265425']] | ['Springer Berlin Heidelberg'] | [['(classificationName=linseach:mapping)inf', 'Application software.', '(classificationName=ddc)004.6', 'Computer programming.', '(classificationName=msc)68N99', 'Computer science', '(classificationName=loc)TK7874.6', '(classificationName=rvk)SS 4800', '(classificationName=bk, id=106418882)54.52 - Software engineering', '(classificationName=bk, id=106417967)54.80 - Angewandte Informatik', '(classificationName=rvk)ST 153', '(classificationName=msc)93C83', 'Computers, Special purpose.', 'Software engineering', '(classificationName=bk, id=106421344)50.23 - Regelungstechnik, Steuerungstechnik', '(classificationName=linseach:mapping)tec', '(classificationName=msc)*68U99', '(classificationName=dbn)37', 'Computer Science', 'Automotive engineering.', '(classificationName=dbn)28', '(classificationName=ddc)004', 'Special purpose computers.', '(classificationName=ddc)005.1', 'Engineering']] | ['Software Frameworks and Embedded Control Systems'] | ['Although framework technology has proven its worth as a software reuse technique in many domains, there have been reservations regarding its application in embedded systems, mostly due to limited CPU and memory resources. Recent hardware advances, however, have changed this picture. This book shows how object-oriented software frameworks can be applied to embedded control systems. A case study of a framework using a set of application dependent design patterns for the orbit control system of satellites is presented'] | ['2002'] | ['http://id.loc.gov/vocabulary/iso639-1/en'] | ['commercial licence'] | [[{'@id': 'gnd:4439521-8'}, {'@id': 'gnd:4546895-3'}, {'@id': 'gnd:4116522-6'}, {'@id': 'gnd:4396978-1'}, {'@id': 'gnd:4113542-8'}, {'@id': 'gnd:4464685-9'}]] | ['gnd:4113542-8', 'gnd:4116522-6', 'gnd:4396978-1', 'gnd:4439521-8', 'gnd:4464685-9', 'gnd:4546895-3', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A1649265425'] | ['Fernüberwachung', 'Softwareentwicklung', 'Eingebettetes System', 'Komponente (Software)', 'Framework (Informatik)', 'Entwurfsmuster'] | 27 |
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