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"title": "Trigeminale Innervation des olfaktorischen Systems : Anatomie und Funktion",
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"The olfactory system serves for the detection of odorants and thus mainly for the identification of food sources or hazards. The trigeminal system is commonly known to have somatosensory properties. However, almost every odorant activates the olfactory as well as the trigeminal system. Many studies dealing with the perception of odorants demonstrate that there are mutual influences between the two systems, but the molecular mechanisms of these interactions are unknown. To gain a better insight into these mechanisms the trigeminal innervation of the olfactory system as well as functional aspects of the trigeminal olfactory interaction were investigated in the present work. Trigeminal fibers that contain and upon stimulation can release the peptides Substance P (SP) and calcitonin gene-related peptide (CGRP) were found in the olfactory epithelium (OE) and the olfactory bulb (OB). Within the OE in many cases these fibers are associated with cell types that differ from regular olfactory neurons. These include microvillous cells, which express components of an inositoltris-phosphate (IP3) signalling pathway and the SP receptor NK1R. Ca2+-imaging experiments show that these cells respond to SP with an increase in the intracellular Ca2+-concentration. Presumably, the response to SP is primarily carried by the release of Ca2+ from internal stores. Immunohistochemical studies indicate the expression of CGRP receptors in a subpopulation of regular olfactory neurons. In Ca2+-imaging experiments some of the cells that responded to odorants also responded to CGRP with an increase in the intracellular Ca2+-concentration. In addition, some of these cells also responded to SP indicating that they might be IP3 receptor-positive microvillous cells (see above). Preliminary results suggest that both regular olfactory neurons and microvillous IP3 receptor-positive cells can respond to CGRP. In the OB every layer is trigeminally innervated, but there is a clear preference for ventrally l",
"Das olfaktorische System dient der Wahrnehmung von Ger\u00fcchen und somit vor allem der Erkennung von Nahrungs- oder Gefahrenquellen. Dem trigeminalen System werden in erster Linie somatosensorische Eigenschaften zugeschrieben. Fast alle Ger\u00fcche aktivieren jedoch neben dem olfaktorischen auch das trigeminale System. Viele Studien, die sich mit der Wahrnehmung von Ger\u00fcchen besch\u00e4ftigen, beweisen, dass es wechselseitige Einfl\u00fcsse zwischen den beiden Systemen gibt. Die molekularen Mechanismen dieser Interaktionen sind jedoch unbekannt. Um ein besseres Verst\u00e4ndnis dieser Mechanismen zu erhalten, wurden in der vorliegenden Arbeit neben der trigeminalen Innervation des Riechsystems auch funktionelle Aspekte der trigeminal/olfaktorischen Interaktion untersucht. Immunhistochemisch wurden trigeminale Fasern, die die Peptide Substanz P (SP) und calcitonin gene-related peptide (CGRP) enthalten und auf einen Reiz hin aussch\u00fctten k\u00f6nnen, im olfaktorischen Epithel (OE) und Bulbus olfactorius (OB) gefunden. Im OE stehen diese Fasern oft mit Zelltypen, die sich von regul\u00e4ren olfaktorischen Neuronen unterscheiden, in Verbindung. Zu diesen z\u00e4hlen unter anderem microvilli\u00e4re Zellen, die Komponenten eines Inositoltrisphosphat (IP3) Signalweges und den SP Rezeptor NK1R exprimieren. Die Ergebnisse von Ca2+-Imaging Experimenten an Gewebsschnitten durch das OE deuten darauf hin, dass die microvilli\u00e4ren Zellen auf SP sowie auf Duftstoffe mit einem Anstieg der intrazellul\u00e4ren Ca2+-Konzentration reagieren. Die Antwort auf SP wird vermutlich haupts\u00e4chlich durch die Freisetzung von Ca2+ aus internen Speichern getragen. Immunhistochemische Untersuchungen geben Hinweise darauf, dass CGRP Rezeptoren in einer Subpopulation von regul\u00e4ren olfaktorischen Neuronen exprimiert werden. In Ca2+-Imaging Versuchen antworteten einige der Zellen, die auf Duftstoffe reagierten, auch auf CGRP mit einem Anstieg der intrazellul\u00e4ren Ca2+-Konzentration. Manche dieser Zellen antworteten zudem auf SP, was vermuten l\u00e4sst"
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} | [] | [] | ['pae'] | ['Technische Informationsbibliothek (TIB)'] | [['(firstid)DNB:1050113624', '(ppn)786242817']] | ['Forschungszentrum, Zentralbibliothek'] | [['(classificationName=ddc)612.86', '(classificationName=linseach:mapping)pae', '(classificationName=bk, id=106413945)77.40 - Wahrnehmungspsychologie', '(classificationName=ddc-dbn)150', '(classificationName=ddc-dbn)610']] | ['Trigeminale Innervation des olfaktorischen Systems : Anatomie und Funktion'] | [['The olfactory system serves for the detection of odorants and thus mainly for the identification of food sources or hazards. The trigeminal system is commonly known to have somatosensory properties. However, almost every odorant activates the olfactory as well as the trigeminal system. Many studies dealing with the perception of odorants demonstrate that there are mutual influences between the two systems, but the molecular mechanisms of these interactions are unknown. To gain a better insight into these mechanisms the trigeminal innervation of the olfactory system as well as functional aspects of the trigeminal olfactory interaction were investigated in the present work. Trigeminal fibers that contain and upon stimulation can release the peptides Substance P (SP) and calcitonin gene-related peptide (CGRP) were found in the olfactory epithelium (OE) and the olfactory bulb (OB). Within the OE in many cases these fibers are associated with cell types that differ from regular olfactory neurons. These include microvillous cells, which express components of an inositoltris-phosphate (IP3) signalling pathway and the SP receptor NK1R. Ca2+-imaging experiments show that these cells respond to SP with an increase in the intracellular Ca2+-concentration. Presumably, the response to SP is primarily carried by the release of Ca2+ from internal stores. Immunohistochemical studies indicate the expression of CGRP receptors in a subpopulation of regular olfactory neurons. In Ca2+-imaging experiments some of the cells that responded to odorants also responded to CGRP with an increase in the intracellular Ca2+-concentration. In addition, some of these cells also responded to SP indicating that they might be IP3 receptor-positive microvillous cells (see above). Preliminary results suggest that both regular olfactory neurons and microvillous IP3 receptor-positive cells can respond to CGRP. In the OB every layer is trigeminally innervated, but there is a clear preference for ventrally l', 'Das olfaktorische System dient der Wahrnehmung von Gerüchen und somit vor allem der Erkennung von Nahrungs- oder Gefahrenquellen. Dem trigeminalen System werden in erster Linie somatosensorische Eigenschaften zugeschrieben. Fast alle Gerüche aktivieren jedoch neben dem olfaktorischen auch das trigeminale System. Viele Studien, die sich mit der Wahrnehmung von Gerüchen beschäftigen, beweisen, dass es wechselseitige Einflüsse zwischen den beiden Systemen gibt. Die molekularen Mechanismen dieser Interaktionen sind jedoch unbekannt. Um ein besseres Verständnis dieser Mechanismen zu erhalten, wurden in der vorliegenden Arbeit neben der trigeminalen Innervation des Riechsystems auch funktionelle Aspekte der trigeminal/olfaktorischen Interaktion untersucht. Immunhistochemisch wurden trigeminale Fasern, die die Peptide Substanz P (SP) und calcitonin gene-related peptide (CGRP) enthalten und auf einen Reiz hin ausschütten können, im olfaktorischen Epithel (OE) und Bulbus olfactorius (OB) gefunden. Im OE stehen diese Fasern oft mit Zelltypen, die sich von regulären olfaktorischen Neuronen unterscheiden, in Verbindung. Zu diesen zählen unter anderem microvilliäre Zellen, die Komponenten eines Inositoltrisphosphat (IP3) Signalweges und den SP Rezeptor NK1R exprimieren. Die Ergebnisse von Ca2+-Imaging Experimenten an Gewebsschnitten durch das OE deuten darauf hin, dass die microvilliären Zellen auf SP sowie auf Duftstoffe mit einem Anstieg der intrazellulären Ca2+-Konzentration reagieren. Die Antwort auf SP wird vermutlich hauptsächlich durch die Freisetzung von Ca2+ aus internen Speichern getragen. Immunhistochemische Untersuchungen geben Hinweise darauf, dass CGRP Rezeptoren in einer Subpopulation von regulären olfaktorischen Neuronen exprimiert werden. In Ca2+-Imaging Versuchen antworteten einige der Zellen, die auf Duftstoffe reagierten, auch auf CGRP mit einem Anstieg der intrazellulären Ca2+-Konzentration. Manche dieser Zellen antworteten zudem auf SP, was vermuten lässt']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['commercial licence'] | [''] | ['gnd:1049669916', 'gnd:4020433-9', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A786242817'] | ['Söchtig, Melanie Anne', 'Geruch'] | 20 |
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} | ['gnd:4316153-4', 'gnd:4236432-2'] | ['Reaktive Sauerstoffspezies', 'NADH-Dehydrogenase (Ubichinon)'] | ['che'] | ['Technische Informationsbibliothek (TIB)'] | [['(ppn)787519111', '(contract)FRUB-opus-9458', '(firstid)BSZ:406602395']] | [''] | [['(classificationName=linseach:mapping)che', '(classificationName=ddc-dbn)540', '(classificationName=linseach:mapping)bio', '(classificationName=ddc-dbn)570', '(classificationName=ddc)540']] | ['Funktionelle und strukturelle Charakterisierung von Varianten des respiratorischen Komplex I'] | [['Zusammenfassung: Reactive oxygen species (ROS) are suspected to be involved in the development of neurodegenerative diseases such as Parkinson\'s disease and Alzheimer\'s disease. In addition, ROS is ascribed an important role in the aging process. The NADH:ubiquinone oxidoreductase, also called respiratory complex I, is the most important source of ROS in the mitochondrion. The enzyme complex couples the electron transfer from NADH to ubiquinone with the translocation of protons across the membrane. Because of its simpler structure of the bacterial complex I is considered as a model system for the eukaryotic complex. The Escherichia coli complex I consists of 13 subunits, which are named NuoA to NuoN. The enzyme carries nine iron-sulfur (Fe/S) clusters and one flavin mononucleotide (FMN) as cofactors. In this work, specific questions concerning the mechanism of complex I were clarified by characterization of site-directed mutants. Effects of mutations on the enzymatic activity were tested using the E. coli complex I. The structural changes of the mutations were, if possible, characterized by a soluble subcomplex consisting of subunits NuoE and F of the Aquifex aeolicus complex I. By mutagenesis of Glu183(NuoF) and characterization of variants, this amino acid has been identified as a key position for the substrate discrimination of NADH and NADPH by complex I. The increased ROS production of the variants during NADH consumption could be explained by the structure of the A. aeolicus NuoEF variant E185D(NuoF) with bound NAD+. The mutation Tyr204Cys(NuoF) was detected in a patient suffering from Leigh-like syndrome. The cause of this disease has been studied by mutagenesis of E. coli complex I. The characterized variants showed up to 80% reduction in catalytic efficiency and 13-fold increase in ROS production. In a cooperation project with the group of Dr. Judy Hirst (MRC , Cambridge ), the midpoint potential of the Fe/S cluster N1a was lowered up to 100 mV by site-directed mutagenesis. N1a of the produced E. coli complex I variant could not be reduced by NADH. This led to an increased H2O2 production by 60 % and shows the functional significance of this cluster as a protection against increased ROS production. The structures of NuoEF with bound substrate and product show a conformational change of the peptide bond of Glu95(NuoF). This reorientation seems to be a kind of "product ejection mechanism". By mutagenesis this peptide bond was fixed in the conformati ...', 'Zusammenfassung: Reaktive Sauerstoffspezies (reactive oxygen species; ROS) stehen im Verdacht an der Entstehung neurodegenerativer Erkrankungen, wie Morbus Parkinson und Morbus Alzheimer beteiligt zu sein. Zusätzlich wird ROS eine wesentliche Rolle beim Alterungsprozess zugeschrieben. Die NADH:Ubichinon Oxidoreduktase, auch respiratorischer Komplex I genannt, gilt als die bedeutendste Quelle von ROS im Mitochondrium. Der Enzymkomplex koppelt den Elektronentransfer von NADH auf Ubichinon mit der Translokation von Protonen über die Membran. Aufgrund seines einfacheren Aufbaus wird der bakterielle Komplex I als Modellsystem für den eukaryotischen Komplex angesehen. Der Escherichia coli Komplex I besteht aus 13 Untereinheiten, die mit NuoA bis NuoN bezeichnet werden und trägt neun Eisen-Schwefel (Fe/S)-Zentren sowie ein Flavinmononukleotid (FMN) als Kofaktoren. In dieser Arbeit wurden spezifische Fragen zum Mechanismus des Komplex I durch Charakterisierung ortsgerichteter Mutanten geklärt. Auswirkungen der Mutationen auf die enzymatische Aktivität wurden mit dem E. coli Komplex I untersucht. Die strukturellen Änderungen der Mutationen wurden, falls möglich, mit dem löslichen Subkomplex aus den Untereinheiten NuoE und F des Aquifex aeolicus Komplex I charakterisiert. Durch Mutagenese des Glu183(NuoF) und durch Charakterisierung der Varianten konnte diese Position als Schlüsselposition für die Substratunterscheidung von NADH und NADPH durch Komplex I identifiziert werden. Die erhöhte ROS-Produktion der Varianten bei der Umsetzung von NADH konnte durch die Struktur der A. aeolicus Variante E185D(NuoF) mit gebundenem Produkt erklärt werden. Die Mutation Tyr204Cys(NuoF) wurde bei einem am Leigh-like-Syndrom erkrankten Patienten nachgewiesen. Die Ursache dieser Erkrankung wurde mit durch die Mutagenese des E. coli Komplex I untersucht. Die charakterisierten Varianten zeigten eine, bis zu 80% verringerte katalytische Effizienz und 13-fach erhöhte ROS-Produktion. In einem Kooperations-Projekt mit der Gruppe von Dr. Judy Hirst (MRC, Cambridge) wurde das Mittenpunktspotential des Fe/S-Zentrums N1a durch ortsgerichtete Mutagenese um bis zu 100 mV abgesenkt. Das Zentrum konnte in der dargestellten Variante nicht mit NADH reduziert werden, was eine um 60% erhöhte H2O2-Produktion zur Folge hatte und funktionelle Bedeutung dieses Zentrums als Schutz vor einer erhöhten ROS-Produktion zeigt. Die Strukturen des NuoEF mit gebundenem Produkt un ...']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4316153-4'}, {'@id': 'gnd:4236432-2'}]] | ['gnd:1052360386', 'gnd:4236432-2', 'gnd:4316153-4', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A787519111'] | ['Frick, Klaudia', 'Reaktive Sauerstoffspezies', 'NADH-Dehydrogenase (Ubichinon)'] | 5 |
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"Zusammenfassung: Reaktive Sauerstoffspezies (reactive oxygen species; ROS) stehen im Verdacht an der Entstehung neurodegenerativer Erkrankungen, wie Morbus Parkinson und Morbus Alzheimer beteiligt zu sein. Zus\u00e4tzlich wird ROS eine wesentliche Rolle beim Alterungsprozess zugeschrieben. Die NADH:Ubichinon Oxidoreduktase, auch respiratorischer Komplex I genannt, gilt als die bedeutendste Quelle von ROS im Mitochondrium. Der Enzymkomplex koppelt den Elektronentransfer von NADH auf Ubichinon mit der Translokation von Protonen \u00fcber die Membran. Aufgrund seines einfacheren Aufbaus wird der bakterielle Komplex I als Modellsystem f\u00fcr den eukaryotischen Komplex angesehen. Der Escherichia coli Komplex I besteht aus 13 Untereinheiten, die mit NuoA bis NuoN bezeichnet werden und tr\u00e4gt neun Eisen-Schwefel (Fe/S)-Zentren sowie ein Flavinmononukleotid (FMN) als Kofaktoren. In dieser Arbeit wurden spezifische Fragen zum Mechanismus des Komplex I durch Charakterisierung ortsgerichteter Mutanten gekl\u00e4rt. Auswirkungen der Mutationen auf die enzymatische Aktivit\u00e4t wurden mit dem E. coli Komplex I untersucht. Die strukturellen \u00c4nderungen der Mutationen wurden, falls m\u00f6glich, mit dem l\u00f6slichen Subkomplex aus den Untereinheiten NuoE und F des Aquifex aeolicus Komplex I charakterisiert. Durch Mutagenese des Glu183(NuoF) und durch Charakterisierung der Varianten konnte diese Position als Schl\u00fcsselposition f\u00fcr die Substratunterscheidung von NADH und NADPH durch Komplex I identifiziert werden. Die erh\u00f6hte ROS-Produktion der Varianten bei der Umsetzung von NADH konnte durch die Struktur der A. aeolicus Variante E185D(NuoF) mit gebundenem Produkt erkl\u00e4rt werden. Die Mutation Tyr204Cys(NuoF) wurde bei einem am Leigh-like-Syndrom erkrankten Patienten nachgewiesen. Die Ursache dieser Erkrankung wurde mit durch die Mutagenese des E. coli Komplex I untersucht. Die charakterisierten Varianten zeigten eine, bis zu 80% verringerte katalytische Effizienz und 13-fach erh\u00f6hte ROS-Produktion. In einem Kooperations-Projekt mit der Gruppe von Dr. Judy Hirst (MRC, Cambridge) wurde das Mittenpunktspotential des Fe/S-Zentrums N1a durch ortsgerichtete Mutagenese um bis zu 100 mV abgesenkt. Das Zentrum konnte in der dargestellten Variante nicht mit NADH reduziert werden, was eine um 60% erh\u00f6hte H2O2-Produktion zur Folge hatte und funktionelle Bedeutung dieses Zentrums als Schutz vor einer erh\u00f6hten ROS-Produktion zeigt. Die Strukturen des NuoEF mit gebundenem Produkt un ..."
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} | ['gnd:4316153-4', 'gnd:4236432-2'] | ['Reaktive Sauerstoffspezies', 'NADH-Dehydrogenase (Ubichinon)'] | ['bio'] | ['Technische Informationsbibliothek (TIB)'] | [['(ppn)787519111', '(contract)FRUB-opus-9458', '(firstid)BSZ:406602395']] | [''] | [['(classificationName=linseach:mapping)che', '(classificationName=ddc-dbn)540', '(classificationName=linseach:mapping)bio', '(classificationName=ddc-dbn)570', '(classificationName=ddc)540']] | ['Funktionelle und strukturelle Charakterisierung von Varianten des respiratorischen Komplex I'] | [['Zusammenfassung: Reactive oxygen species (ROS) are suspected to be involved in the development of neurodegenerative diseases such as Parkinson\'s disease and Alzheimer\'s disease. In addition, ROS is ascribed an important role in the aging process. The NADH:ubiquinone oxidoreductase, also called respiratory complex I, is the most important source of ROS in the mitochondrion. The enzyme complex couples the electron transfer from NADH to ubiquinone with the translocation of protons across the membrane. Because of its simpler structure of the bacterial complex I is considered as a model system for the eukaryotic complex. The Escherichia coli complex I consists of 13 subunits, which are named NuoA to NuoN. The enzyme carries nine iron-sulfur (Fe/S) clusters and one flavin mononucleotide (FMN) as cofactors. In this work, specific questions concerning the mechanism of complex I were clarified by characterization of site-directed mutants. Effects of mutations on the enzymatic activity were tested using the E. coli complex I. The structural changes of the mutations were, if possible, characterized by a soluble subcomplex consisting of subunits NuoE and F of the Aquifex aeolicus complex I. By mutagenesis of Glu183(NuoF) and characterization of variants, this amino acid has been identified as a key position for the substrate discrimination of NADH and NADPH by complex I. The increased ROS production of the variants during NADH consumption could be explained by the structure of the A. aeolicus NuoEF variant E185D(NuoF) with bound NAD+. The mutation Tyr204Cys(NuoF) was detected in a patient suffering from Leigh-like syndrome. The cause of this disease has been studied by mutagenesis of E. coli complex I. The characterized variants showed up to 80% reduction in catalytic efficiency and 13-fold increase in ROS production. In a cooperation project with the group of Dr. Judy Hirst (MRC , Cambridge ), the midpoint potential of the Fe/S cluster N1a was lowered up to 100 mV by site-directed mutagenesis. N1a of the produced E. coli complex I variant could not be reduced by NADH. This led to an increased H2O2 production by 60 % and shows the functional significance of this cluster as a protection against increased ROS production. The structures of NuoEF with bound substrate and product show a conformational change of the peptide bond of Glu95(NuoF). This reorientation seems to be a kind of "product ejection mechanism". By mutagenesis this peptide bond was fixed in the conformati ...', 'Zusammenfassung: Reaktive Sauerstoffspezies (reactive oxygen species; ROS) stehen im Verdacht an der Entstehung neurodegenerativer Erkrankungen, wie Morbus Parkinson und Morbus Alzheimer beteiligt zu sein. Zusätzlich wird ROS eine wesentliche Rolle beim Alterungsprozess zugeschrieben. Die NADH:Ubichinon Oxidoreduktase, auch respiratorischer Komplex I genannt, gilt als die bedeutendste Quelle von ROS im Mitochondrium. Der Enzymkomplex koppelt den Elektronentransfer von NADH auf Ubichinon mit der Translokation von Protonen über die Membran. Aufgrund seines einfacheren Aufbaus wird der bakterielle Komplex I als Modellsystem für den eukaryotischen Komplex angesehen. Der Escherichia coli Komplex I besteht aus 13 Untereinheiten, die mit NuoA bis NuoN bezeichnet werden und trägt neun Eisen-Schwefel (Fe/S)-Zentren sowie ein Flavinmononukleotid (FMN) als Kofaktoren. In dieser Arbeit wurden spezifische Fragen zum Mechanismus des Komplex I durch Charakterisierung ortsgerichteter Mutanten geklärt. Auswirkungen der Mutationen auf die enzymatische Aktivität wurden mit dem E. coli Komplex I untersucht. Die strukturellen Änderungen der Mutationen wurden, falls möglich, mit dem löslichen Subkomplex aus den Untereinheiten NuoE und F des Aquifex aeolicus Komplex I charakterisiert. Durch Mutagenese des Glu183(NuoF) und durch Charakterisierung der Varianten konnte diese Position als Schlüsselposition für die Substratunterscheidung von NADH und NADPH durch Komplex I identifiziert werden. Die erhöhte ROS-Produktion der Varianten bei der Umsetzung von NADH konnte durch die Struktur der A. aeolicus Variante E185D(NuoF) mit gebundenem Produkt erklärt werden. Die Mutation Tyr204Cys(NuoF) wurde bei einem am Leigh-like-Syndrom erkrankten Patienten nachgewiesen. Die Ursache dieser Erkrankung wurde mit durch die Mutagenese des E. coli Komplex I untersucht. Die charakterisierten Varianten zeigten eine, bis zu 80% verringerte katalytische Effizienz und 13-fach erhöhte ROS-Produktion. In einem Kooperations-Projekt mit der Gruppe von Dr. Judy Hirst (MRC, Cambridge) wurde das Mittenpunktspotential des Fe/S-Zentrums N1a durch ortsgerichtete Mutagenese um bis zu 100 mV abgesenkt. Das Zentrum konnte in der dargestellten Variante nicht mit NADH reduziert werden, was eine um 60% erhöhte H2O2-Produktion zur Folge hatte und funktionelle Bedeutung dieses Zentrums als Schutz vor einer erhöhten ROS-Produktion zeigt. Die Strukturen des NuoEF mit gebundenem Produkt un ...']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4316153-4'}, {'@id': 'gnd:4236432-2'}]] | ['gnd:1052360386', 'gnd:4236432-2', 'gnd:4316153-4', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A787519111'] | ['Frick, Klaudia', 'Reaktive Sauerstoffspezies', 'NADH-Dehydrogenase (Ubichinon)'] | 3 |
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} | ['gnd:4135470-9', 'gnd:4171600-0', 'gnd:4068943-8', 'gnd:4165216-2', 'gnd:4297929-8', 'gnd:4172466-5', 'gnd:4064317-7', 'gnd:4019702-5'] | ['Gefühl', 'Wahrnehmung', 'Aufmerksamkeit', 'Affekt', 'Konzentrationsfähigkeit', 'Neurotizismus', 'Estradiol', 'Achtsamkeit'] | ['pae'] | [['Technische Informationsbibliothek (TIB)', {'@id': 'gnd:12963462X'}]] | [['(firstid)DNB:1051433479', '(ppn)788332554']] | [''] | [['(classificationName=bk, id=106414313)81.52 - Lernleistung', '(classificationName=bk, id=106416413)77.37 - Aufmerksamkeit', '(classificationName=ddc-dbn)DDC150', '(classificationName=linseach:mapping)pae', '(classificationName=bk, id=106418432)77.46 - Emotion', '(classificationName=ddc-dbn)150', '(classificationName=bk, id=106413945)77.40 - Wahrnehmungspsychologie']] | ['The distribution of attention in RSVP tasks and its sensitivity to affect, personality traits and estradiol'] | [['In this thesis, the influences of positive and negative affect state, the personality trait neuroticism, and the hormone estradiol on selective attention are explored in three studies. In Study 1 a double-stream RSVP paradigm was used to explore if attention can be spatially diffused and focused by affect. A spatial interpretation of the diffuse mental state was not found. Study 2 studied the distribution of attention as influenced by neuroticism and cognitive control. Results confirmed that as expected low control lowered relative power difference between the ssVEP responses to the two streams. In Study 3, the effect of fluctuating estradiol over the menstrual cycle on attention was investigated with alpha asymmetry as a possible mediator. Results indicate relationships between alpha and estradiol, and between alpha and performance. <engl.>', 'Diese Arbeit untersucht den Einfluss von positivem und negativem Affekt, des Persönlichkeitsmerkmals Neurotizismus, und des Hormons Estradiol auf selektive Aufmerksamkeit. In Studie 1 wurde der Affekt in einem double-stream RSVP Paradigma manipuliert, um zu untersuchen ob dadurch Aufmerksamkeit räumlich erweitert oder fokussiert wird. Es konnte kein solcher Effekt nachgewiesen werden. Studie 2 untersuchte den Zusammenhang von Neurotizismus und kognitiver Kontrolle auf die Aufmerksamkeitsverteilung mittels eines ssVEP Paradigmas. Die Ergebnisse zeigen einen negativen Zusammenhang zwischen Neurotizismus und Power-Unterschieden zwischen zwei ssVEP Strömen. In Studie 3 wurde der Einfluss der menstruellen Estradiolschwankung, mit Alpha-Asymmetrie als möglichen Mediator, auf die Aufmerksamkeit erforscht. Die Ergebnisse zeigten Zusammenhänge zwischen Alpha und Estradiol, sowie zwischen Alpha und behavioraler Leistung. <dt.>']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/en'] | ['commercial licence'] | [[{'@id': 'gnd:4135470-9'}, {'@id': 'gnd:4171600-0'}, {'@id': 'gnd:4068943-8'}, {'@id': 'gnd:4165216-2'}, {'@id': 'gnd:4297929-8'}, {'@id': 'gnd:4172466-5'}, {'@id': 'gnd:4064317-7'}, {'@id': 'gnd:4019702-5'}]] | ['gnd:1055850228', 'gnd:12963462X', 'gnd:4019702-5', 'gnd:4064317-7', 'gnd:4068943-8', 'gnd:4135470-9', 'gnd:4165216-2', 'gnd:4171600-0', 'gnd:4172466-5', 'gnd:4297929-8', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A788332554'] | ['Dhinakaran, Janani', 'Kranczioch, Cornelia', 'Gefühl', 'Wahrnehmung', 'Aufmerksamkeit', 'Affekt', 'Konzentrationsfähigkeit', 'Neurotizismus', 'Estradiol', 'Achtsamkeit'] | 20 |
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"title": "Information flows in the context of EU policy-making : affiliation networks and the post-2012 reform of the EU's Common Fisheries Policy",
"abstract": "Information flows in EU policy-making are heavily dependent on personal networks, both within the Brussels sphere but also reaching outside the narrow limits of the Belgian capital. These networks develop for example in the course of formal and informal meetings or at the sidelines of such meetings. A plethora of committees at European, transnational and regional level provides the basis for the establishment of pan-European networks. By studying affiliation to those committees, basic network structures can be uncovered. These affiliation network structures can then be used to predict EU information flows, assuming that certain positions within the network are advantageous for tapping into streams of information while others are too remote and peripheral to provide access to information early enough. This study has tested those assumptions for the case of the reform of the Common Fisheries Policy for the time after 2012. Through the analysis of an affiliation network based on participation in 10 different fisheries policy committees over two years (2009 and 2010), network data for an EU-wide network of about 1300 fisheries interest group representatives and more than 200 events was collected. The structure of this network showed a number of interesting patterns, such as not surprisingly a rather central role of Brussels-based committees but also close relations of very specific interests to the Brussels-cluster and stronger relations between geographically closer maritime regions. The analysis of information flows then focused on access to draft EU Commission documents containing the upcoming proposal for a new basic regulation of the Common Fisheries Policy. It was first documented that it would have been impossible to officially obtain this document and that personal networks were thus the most likely sources for fisheries policy actors to obtain access to these \u201cleaks\u201d in early 2011. A survey of a sample of 65 actors from the initial network supported these findings: Only a very small group had accessed the draft directly from the Commission. Most respondents who obtained access to the draft had received it from other actors, highlighting the networked flow of informal information in EU politics. Furthermore, the testing of the hypotheses connecting network positions and the level of informedness indicated that presence in or connections to the Brussels sphere had both advantages for overall access to the draft document and with regard to timing. Methodologically, challenges of both the network analysis and the analysis of information flows but also their relevance for the study of EU politics have been documented. In summary, this study has laid the foundation for a different way to study EU policy-making by connecting topical and methodological elements \u2013 such as affiliation network analysis and EU committee governance \u2013 which so far have not been considered together, thereby contributing in various ways to political science and EU studies.",
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} | ['gnd:4184374-5', 'gnd:4415032-5'] | ['Tal', 'Eisrand'] | ['his'] | [['gnd:138869677', 'gnd:138868751', 'gnd:138870756', 'gnd:1024475557', 'gnd:123748674']] | [['(firstid)DNB:1055814477', '(ppn)796308845']] | ['Niedersächsische Staats- und Universitätsbibliothek Göttingen'] | [['(classificationName=linseach:mapping)geo', '(classificationName=linseach:mapping)his', '(classificationName=ddc-dbn)550', '(classificationName=ddc-dbn)910']] | ['Die Eisrandtäler im Karakorum : Verbreitung, Genese und Morphodynamik des lateroglazialen Sedimentformenschatzes'] | [['The research study provides a contribution to the geomorphological survey of the lateroglacial landform assemblage along subtropical high mountain glaciers in the Karakoram (72°-79°E; 35°-36°N). The ice-marginal valleys and their lateroglacial landform associations were investigated systematically as a distinct sedimentation environment along 43 glaciers in regard to their distribution, evolution and morphodynamics. The vertical distribution of the present lateroglacial sediments ranges between an altitude of approx. 2350 m and 5200 m. Up to now, especially kame terraces and lateral moraine...', 'Die vorliegende Forschungsarbeit liefert einen Beitrag zur geomorphologischen Erfassung des lateroglazialen Formenschatzes entlang subtropischer Gletscher im Karakorum (72°-79°E; 35°-36°N). Die Eisrandtäler (Ufertäler) und ihr lateroglazialer Sedimentformenschatz wurden erstmals als ausgesonderter Sedimentationsraum an 43 Gletschern hinsichtlich ihrer räumlichen Verbreitung, Genese und Morphodynamik systematisch untersucht. Bislang waren für den eismarginalen Bereich insbesondere Kameterrassen im Sinne von glazifluvialen Ablagerungsformen sowie Ufermoränenkomplexe im geomorphologischen Inve...']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4184374-5'}, {'@id': 'gnd:4415032-5'}]] | ['gnd:1024475557', 'gnd:1041847343', 'gnd:123748674', 'gnd:138868751', 'gnd:138869677', 'gnd:138870756', 'gnd:4073227-7', 'gnd:4184374-5', 'gnd:4415032-5', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A796308845'] | ['Cyffka, Bernd', 'Iturrizaga, Lasafam', 'Ehlers, Jürgen', 'Baume, Otfried', 'Kuhle, Matthias', 'Schröder, Hilmar', 'Karakorum', 'Tal', 'Eisrand'] | 9 |
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} | ['gnd:4171869-0', 'gnd:4018406-7', 'gnd:4115348-0'] | ['Tourismus', 'Naturschutz', 'Niederwald'] | ['oek'] | ['Technische Informationsbibliothek (TIB)'] | [['(contract)FRUB-opus-9655', '(firstid)BSZ:41410899X', '(ppn)796784647']] | [''] | [['(classificationName=ddc)634.95094343', '(classificationName=linseach:mapping)oek', '(classificationName=ddc)630', '(classificationName=ddc-dbn)630', '(classificationName=ddc-dbn)333.7', '(classificationName=linseach:mapping)hor']] | ['Multifunktionalität von Niederwäldern in Rheinland-Pfalz : Aspekte des Naturschutzes und des Tourismus'] | [['Zusammenfassung: According to estimates, there are approximately 160 000 ha of forest in Rheinland-Pfalz the origins of which can be traced back to traditional coppice management. Up until the transition from the 19th to the 20th century, coppice was a widespread form of land use in central European broadleaf forests and represented a considerable potential source of wood. These forests were customarily managed in short rotations (usually a maximum of 40 years). Today, however, the majority these stands are now between 60 and 90 years old as, due to a lack of profitability since the postwar period, they have not been coppiced in the intervening years and have outgrown. As a consequence of the recent increase in the demand for woodfuel, coppice management has become an attractive option once more as a means to produce wood for energy use. Coppice forests are also attributed considerable nature conservation value and a high cultural significance. A resumption of coppice management along traditional lines today is largely inconceivable, however. For this reason, it was deemed necessary to collate new findings pertaining to a modern form of coppice management practised in the context of current forest policy, economic aims and ecological objectives as well as in view of technological advances made in timber harvesting. To this end, numerous studies were undertaken as part of the practice-oriented research project ‘Schutz und Nutzung: Ein Raum-Zeit-Konzept für die multifunktionale Entwicklung der Stockausschlagwälder in Rheinland-Pfalz’ [Protection and use: A space and time concept for the multifunctional development of coppice forests in Rheinland-Pfalz]. The project results served to clarify the political, economic and silvicultural framework conditions for modern coppice management, and its role in nature protection and its potential to contribute to regional tourism were assessed. Core elements of the study presented here are the nature conservation and tourism aspects of coppice management', 'Zusammenfassung: In Rheinland-Pfalz befinden sich nach Schätzungen etwa 160.000 ha Stockausschlagwälder, die in ihrer Entstehung auf die traditionelle Niederwaldbewirtschaftung zurückzuführen sind. Die Niederwaldwirtschaft war bis zum Übergang vom 19. zum 20. Jh. in Mitteleuropa eine weit verbreitete Nutzungsform des Laubwaldes und bot dabei ein bedeutendes Holzpotenzial. Herkömmlich wurden die Niederwälder in einer kurzen Umtriebszeit (i.d.R. max. 40 Jahre) bewirtschaftet, sind allerdings mittlerweile schwerpunktmäßig zwischen 60 und 90 Jahre alt, da sie aufgrund mangelnder Rentabilität seit den Nachkriegszeiten nicht mehr „auf den Stock gesetzt“ wurden und folglich durchgewachsen sind. Im Zuge der in jüngster Vergangenheit verstärkten Nachfrage nach Energieholz erfährt die Niederwaldbewirtschaftung mit dem Ziel der Brennholzerzeugung wieder mehr Interesse. Zudem kommen den Niederwäldern eine erhebliche naturschutzfachliche sowie eine hohe landeskulturelle Bedeutung zu. Eine Wiederaufnahme der Niederwaldwirtschaft durch traditionelle Nutzungsweise ist allerdings nicht mehr vorstellbar, weshalb es sich als nötig erwies, neue Erkenntnisse unter Berücksichtigung der aktuellen forstpolitischen, -ökonomischen und -ökologischen Ziele sowie technischer Fortschritte in den Holzernteverfahren zu einer zeitgemäßen Niederwaldnutzung zu sammeln. Die vorliegende Arbeit entstand im Rahmen des praxisorientierten Forschungsprojektes "Schutz und Nutzung: Ein Raum-Zeit-Konzept für die multifunktionale Entwicklung der Stockausschlagwälder in Rheinland-Pfalz". Als Ergebnis des Projektes wurden die politischen, wirtschaftlichen und waldbaulichen Rahmenbedingungen einer modernen Niederwaldbewirtschaftung aufgeklärt sowie ihre Rolle im Naturschutz und deren touristische Nutzugsmöglichkeit auf Landesebene überprüft. Im Mittelpunkt der vorliegenden Arbeit stehen die naturschutzfachlichen und touristischen Aspekte der Niederwaldwirtschaft']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4171869-0'}, {'@id': 'gnd:4018406-7'}, {'@id': 'gnd:4115348-0'}]] | ['gnd:1058227432', 'gnd:4018406-7', 'gnd:4049795-1', 'gnd:4115348-0', 'gnd:4171869-0', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A796784647'] | ['Helfrich-Hau, Tímea', 'Tourismus', 'Rheinland-Pfalz', 'Naturschutz', 'Niederwald'] | 19 |
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} | ['gnd:4171869-0', 'gnd:4018406-7', 'gnd:4115348-0'] | ['Tourismus', 'Naturschutz', 'Niederwald'] | ['hor'] | ['Technische Informationsbibliothek (TIB)'] | [['(contract)FRUB-opus-9655', '(firstid)BSZ:41410899X', '(ppn)796784647']] | [''] | [['(classificationName=ddc)634.95094343', '(classificationName=linseach:mapping)oek', '(classificationName=ddc)630', '(classificationName=ddc-dbn)630', '(classificationName=ddc-dbn)333.7', '(classificationName=linseach:mapping)hor']] | ['Multifunktionalität von Niederwäldern in Rheinland-Pfalz : Aspekte des Naturschutzes und des Tourismus'] | [['Zusammenfassung: According to estimates, there are approximately 160 000 ha of forest in Rheinland-Pfalz the origins of which can be traced back to traditional coppice management. Up until the transition from the 19th to the 20th century, coppice was a widespread form of land use in central European broadleaf forests and represented a considerable potential source of wood. These forests were customarily managed in short rotations (usually a maximum of 40 years). Today, however, the majority these stands are now between 60 and 90 years old as, due to a lack of profitability since the postwar period, they have not been coppiced in the intervening years and have outgrown. As a consequence of the recent increase in the demand for woodfuel, coppice management has become an attractive option once more as a means to produce wood for energy use. Coppice forests are also attributed considerable nature conservation value and a high cultural significance. A resumption of coppice management along traditional lines today is largely inconceivable, however. For this reason, it was deemed necessary to collate new findings pertaining to a modern form of coppice management practised in the context of current forest policy, economic aims and ecological objectives as well as in view of technological advances made in timber harvesting. To this end, numerous studies were undertaken as part of the practice-oriented research project ‘Schutz und Nutzung: Ein Raum-Zeit-Konzept für die multifunktionale Entwicklung der Stockausschlagwälder in Rheinland-Pfalz’ [Protection and use: A space and time concept for the multifunctional development of coppice forests in Rheinland-Pfalz]. The project results served to clarify the political, economic and silvicultural framework conditions for modern coppice management, and its role in nature protection and its potential to contribute to regional tourism were assessed. Core elements of the study presented here are the nature conservation and tourism aspects of coppice management', 'Zusammenfassung: In Rheinland-Pfalz befinden sich nach Schätzungen etwa 160.000 ha Stockausschlagwälder, die in ihrer Entstehung auf die traditionelle Niederwaldbewirtschaftung zurückzuführen sind. Die Niederwaldwirtschaft war bis zum Übergang vom 19. zum 20. Jh. in Mitteleuropa eine weit verbreitete Nutzungsform des Laubwaldes und bot dabei ein bedeutendes Holzpotenzial. Herkömmlich wurden die Niederwälder in einer kurzen Umtriebszeit (i.d.R. max. 40 Jahre) bewirtschaftet, sind allerdings mittlerweile schwerpunktmäßig zwischen 60 und 90 Jahre alt, da sie aufgrund mangelnder Rentabilität seit den Nachkriegszeiten nicht mehr „auf den Stock gesetzt“ wurden und folglich durchgewachsen sind. Im Zuge der in jüngster Vergangenheit verstärkten Nachfrage nach Energieholz erfährt die Niederwaldbewirtschaftung mit dem Ziel der Brennholzerzeugung wieder mehr Interesse. Zudem kommen den Niederwäldern eine erhebliche naturschutzfachliche sowie eine hohe landeskulturelle Bedeutung zu. Eine Wiederaufnahme der Niederwaldwirtschaft durch traditionelle Nutzungsweise ist allerdings nicht mehr vorstellbar, weshalb es sich als nötig erwies, neue Erkenntnisse unter Berücksichtigung der aktuellen forstpolitischen, -ökonomischen und -ökologischen Ziele sowie technischer Fortschritte in den Holzernteverfahren zu einer zeitgemäßen Niederwaldnutzung zu sammeln. Die vorliegende Arbeit entstand im Rahmen des praxisorientierten Forschungsprojektes "Schutz und Nutzung: Ein Raum-Zeit-Konzept für die multifunktionale Entwicklung der Stockausschlagwälder in Rheinland-Pfalz". Als Ergebnis des Projektes wurden die politischen, wirtschaftlichen und waldbaulichen Rahmenbedingungen einer modernen Niederwaldbewirtschaftung aufgeklärt sowie ihre Rolle im Naturschutz und deren touristische Nutzugsmöglichkeit auf Landesebene überprüft. Im Mittelpunkt der vorliegenden Arbeit stehen die naturschutzfachlichen und touristischen Aspekte der Niederwaldwirtschaft']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4171869-0'}, {'@id': 'gnd:4018406-7'}, {'@id': 'gnd:4115348-0'}]] | ['gnd:1058227432', 'gnd:4018406-7', 'gnd:4049795-1', 'gnd:4115348-0', 'gnd:4171869-0', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A796784647'] | ['Helfrich-Hau, Tímea', 'Tourismus', 'Rheinland-Pfalz', 'Naturschutz', 'Niederwald'] | 10 |
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} | [] | [] | ['sow'] | ['Technische Informationsbibliothek (TIB)'] | [['(ppn)797480269', '(firstid)BSZ:414805879']] | [''] | [['(classificationName=ddc-dbn)300', '(classificationName=ddc-dbn)370', '(classificationName=linseach:mapping)pae', '(classificationName=ddc)300', '(classificationName=linseach:mapping)sow']] | ['Die Implementierung des Kleingruppenprojektmodells und der PROGRESS-Methode : eine vergleichende Evaluationsstudie; work together in ... PROGRESS'] | [['The study examines the effectiveness of two Fortbildungsmodi - School-based Teacher Training (SCHILF) and Regional Educators. She juxtaposes the two educational concepts and looks for the differences in the transfer success of the training object. Under the use of qualitative research tools can be shown that School-based Teacher Training and Regional Educators only marginally differ in effectiveness from one another and the training mode for the transfer success is subordinated.', 'Die Studie untersucht die Wirksamkeit zweier Fortbildungsmodi – Schulinterne Lehrerfortbildung (SCHILF) und Regionale Lehrerfortbildung. Dabei stellt sie die beiden Fortbildungskonzepte gegenüber und sucht nach den Unterschieden im Transfererfolg des Fortbildungsgegenstandes. Unter dem Einsatz qualitativer Forschungswerkzeuge kann gezeigt werden, dass sich Schulinterne Lehrerfortbildung und Regionale Lehrerfortbildung nur marginal in der Wirksamkeit voneinander unterscheiden und der Fortbildungsmodus für den Transfererfolg nachrangig ist.']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [''] | ['gnd:4035096-4', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A797480269'] | ['Lehrerfortbildung'] | 25 |
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"The ability to select relevant information from the environment is limited by the resolution of attention \u2013 i.e., by the minimum size of the region that can be selected by attention. Contrary to many other aspects of attention, the development of this limit has not been investigated in children so far. The aim of this dissertation is to investigate both the development of attentional resolution during school age and the mechanisms underlying this development. We addressed this question in two behavioral experiments and one functional magnetic resonance imaging (fMRI) experiment. In those experiments, subjects of different age groups performed an object tracking task with varying distances between target(s) and distractors. In experiment 1, absolute thresholds \u2013 corresponding to the resolution of attention \u2013 were determined for 7-, 9- and 11-year-old children, 13-year-old adolescents and an adult sample. A comparison of the thresholds revealed that the resolution of attention develops markedly between childhood and adulthood. Experiment 2 tested the hypotheses that this development can be attributed to an age-related increase in processing resources by varying the number of targets in addition to target-distractor distance. Increasing the number of targets lead to an increase in the absolute threshold across all age groups. However, this increase was especially pronounced in those age groups that had been characterized by a low resolution of attention in Experiment 1. This indicates that the lower attentional resolution of the younger age groups may be related to a lack of an adequate amount of processing resources which restrains them from constricting the focus of attention in an adult-like manner. In Experiment 3, fMRI was performed in children aged 7 years, 11 years, and in young adults to investigate the neural mechanisms underlying the resolution of attention. Increasing the required resolution of attention led to activation increases in fronto-insular cortex, medial frontal cortex including anterior cingulate cortex (ACC) and supplementary motor area, and superior colliculi and thalamus. This circuitry was recruited by all age groups, but ACC showed an age-related activation reduction. Moreover, several non-task-specific areas showed additional activation in the 7-year-olds and decreased activation in the 11-year-olds as compared to the adult sample. Our results suggest that age-related improvements in the resolution of attention are characterized by an increased use of more functionally specialized brain regions during the course of development. In sum, the present results link the marked development of the resolution of attention to an age-related increase in processing resources. On a neurophysiological level, our findings highlight a role of the saliency network in the context of the resolution of attention. From a developmental perspective, the present results establish that children make use of these circuits from an early age. At the same time, however, children show an increasingly specialized use of these brain regions possibly resulting in the increase in processing resources observed at the behavioral level.",
"Das Ziel der vorliegenden Untersuchung bestand darin, die Entwicklung der Aufl\u00f6sung der Aufmerksamkeit im Kindes- und fr\u00fchen Jugendalter zu charakterisieren und die der Entwicklung zugrunde liegenden Mechanismen zu untersuchen. Zur Untersuchung dieser Fragestellung wurde das Object-Tracking-Paradigma in zwei Verhaltensexperimenten und einem fMRT-Experiment bei Kindern unterschiedlicher Altersgruppen und bei Erwachsenen verwendet. In der ersten Studie wurden sieben-, neun-, elf- und dreizehnj\u00e4hrigen Kindern sowie Erwachsenen das Object-Tracking-Paradigma mit variierendem Abstand zwischen Zielreiz und Distraktoren dargeboten, um den kritischen Abstand der verschiedenen Altersgruppen bestimmen und den Entwicklungsverlauf des kritischen Abstandes \u00fcber den beobachteten Altersbereich beschreiben zu k\u00f6nnen. In diesem Entwicklungsverlauf zeigten sich bedeutsame altersbedingte Ver\u00e4nderungen der Aufl\u00f6sung der Aufmerksamkeit. Der kritische Abstand nahm zwischen 7 und 11 Jahren bedeutend ab, blieb zwischen 11 Jahren und 13 Jahren gleich und sank dann noch einmal bedeutsam zum Erwachsenenalter hin. In einer Kontrollaufgabe konnte gezeigt werden, dass sich die dynamische Sehsch\u00e4rfe im gleichen Alterszeitraum nicht ver\u00e4nderte, woraus geschlossen werden kann, dass die Ver\u00e4nderung der Aufl\u00f6sung der Aufmerksamkeit nicht auf die Entwicklung dieser \u2013 der Aufl\u00f6sung der Aufmerksamkeit m\u00f6glicherweise zugrunde liegenden \u2013 visuellen F\u00e4higkeit zur\u00fcckzuf\u00fchren ist. In der zweiten Studie wurde in der Object-Tracking-Aufgabe neben dem Abstand zwischen Zielreiz und Distraktoren die Anzahl der Zielreize in zwei Stufen (zwei vs. drei Objekte) variiert. Es zeigte sich hier, dass der kritische Abstand von zwei zu drei Zielreizen \u00fcber alle Altersgruppen hinweg anstieg. Die Reduktion der pro Zielreiz zur Verf\u00fcgung stehenden Verarbeitungsressourcen bewirkte somit, dass der Fokus der Aufmerksamkeit weniger eng zusammen gezogen werden konnte. Das Ausma\u00df des Anstiegs des kritischen Abstandes in den verschiedenen Altersgruppen zeichnete zudem den Entwicklungsverlauf der Aufl\u00f6sung der Aufmerksamkeit in Experiment 1 nach. Das hei\u00dft, dass der kritische Abstand von zwei zu drei Objekten bei Kindern st\u00e4rker als bei Erwachsenen zunahm und innerhalb der Kinderstichproben in den Altersgruppen besonders zunahm, die in Experiment 1 eine geringere Aufl\u00f6sung der Aufmerksamkeit gezeigt hatten. Hieraus l\u00e4sst sich schlie\u00dfen, dass bei Kindern die Verringerung der pro Objekt zur Verf\u00fcgung stehenden Verarbeitungsressourcen in besonderem Ma\u00dfe dazu f\u00fchrte, dass sie den Fokus der Aufmerksamkeit weniger eng zusammenziehen konnten. Dies deutet darauf hin, dass die in Experiment 1 beobachtete Entwicklung der Aufl\u00f6sung der Aufmerksamkeit damit im Zusammenhang steht, dass den j\u00fcngeren Altersgruppen nicht ausreichend Verarbeitungsressourcen zur Verf\u00fcgung stehen, um den Aufmerksamkeitsfokus so eng wie Erwachsene zusammenzuziehen. In der dritten Studie wurden die neuronalen Korrelate der Aufl\u00f6sung der Aufmerksamkeit bei sieben- und elfj\u00e4hrigen Kindern und bei Erwachsenen verglichen. Entgegen der Erwartung, dass erh\u00f6hte Anforderungen an die Pr\u00e4zision der Selektion mit einer erh\u00f6hten Aktivierung der FEF einhergehen w\u00fcrden, f\u00fchrte das Zusammenziehen des Fokus der Aufmerksamkeit zu einem Anstieg der neuronalen Aktivit\u00e4t im Salienznetzwerk aus FIC, ACC und Thalamus. Die Aktivierung dieser Areale wies eine hohe Stabilit\u00e4t zwischen 7 Jahren und dem Erwachsenenalter auf. Gleichzeitig zeigten sich jedoch auch Abweichungen in den Aktivierungsmustern von Kindern und Erwachsenen. Innerhalb des Netzwerkes, das \u00fcber alle Altersgruppen als Antwort auf erh\u00f6hte Anforderungen an die Pr\u00e4zision der Selektion aktiviert wurde, zeigte sich eine altersbedingte Reduktion der Aktivierung im ACC. Daneben wurden zus\u00e4tzlich entwicklungsbedingte Aktivierungsabweichungen im linken superioren frontalen Gyrus, dem Precuneus, dem posterioren cingul\u00e4ren Gyrus und bilateral im lateralen okzipito-temporalen Kortex sichtbar. Dies deutet darauf hin, dass bei Kindern ein Zusammenziehen des Fokus der Aufmerksamkeit durch Kontrollsignale aus von Erwachsenen abweichenden Arealen geleistet wird. Zusammengenommen deuten die Ergebnisse von Experiment 2 und Experiment 3 darauf hin, dass die Entwicklung der Aufl\u00f6sung der Aufmerksamkeit, die in Experiment 1 f\u00fcr das Schulalter beobachtet werden konnte, auf eine altersbedingte Zunahme der Verarbeitungsressourcen zur\u00fcckzuf\u00fchren ist. Auf neuronaler Ebene unterstreichen die vorliegenden Ergebnisse die Bedeutung des Salienznetzwerkes f\u00fcr die Aufl\u00f6sung der Aufmerksamkeit und zeigen, dass dieses Netzwerk ab einem fr\u00fchen Alter verwendet wird, um die Pr\u00e4zision der Selektion zu erh\u00f6hen. Gleichzeitig wird die Verwendung dieses Netzwerkes jedoch mit zunehmendem Alter spezifischer, was m\u00f6glicherweise dazu f\u00fchrt, dass auf Verhaltensebene eine Zunahme der Verarbeitungsressourcen beobachtet werden kann."
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} | ['gnd:4133279-9', 'gnd:4068943-8'] | ['Aufmerksamkeit', 'Kognitive Entwicklung'] | ['pae'] | ['Technische Informationsbibliothek (TIB)'] | [['(firstid)BSZ:414806573', '(ppn)797480277']] | [''] | [['(classificationName=ddc)150', '(classificationName=ddc-dbn)150', '(classificationName=linseach:mapping)pae']] | ['Die Entwicklung der Auflösung der Aufmerksamkeit'] | [['The ability to select relevant information from the environment is limited by the resolution of attention – i.e., by the minimum size of the region that can be selected by attention. Contrary to many other aspects of attention, the development of this limit has not been investigated in children so far. The aim of this dissertation is to investigate both the development of attentional resolution during school age and the mechanisms underlying this development. We addressed this question in two behavioral experiments and one functional magnetic resonance imaging (fMRI) experiment. In those experiments, subjects of different age groups performed an object tracking task with varying distances between target(s) and distractors. In experiment 1, absolute thresholds – corresponding to the resolution of attention – were determined for 7-, 9- and 11-year-old children, 13-year-old adolescents and an adult sample. A comparison of the thresholds revealed that the resolution of attention develops markedly between childhood and adulthood. Experiment 2 tested the hypotheses that this development can be attributed to an age-related increase in processing resources by varying the number of targets in addition to target-distractor distance. Increasing the number of targets lead to an increase in the absolute threshold across all age groups. However, this increase was especially pronounced in those age groups that had been characterized by a low resolution of attention in Experiment 1. This indicates that the lower attentional resolution of the younger age groups may be related to a lack of an adequate amount of processing resources which restrains them from constricting the focus of attention in an adult-like manner. In Experiment 3, fMRI was performed in children aged 7 years, 11 years, and in young adults to investigate the neural mechanisms underlying the resolution of attention. Increasing the required resolution of attention led to activation increases in fronto-insular cortex, medial frontal cortex including anterior cingulate cortex (ACC) and supplementary motor area, and superior colliculi and thalamus. This circuitry was recruited by all age groups, but ACC showed an age-related activation reduction. Moreover, several non-task-specific areas showed additional activation in the 7-year-olds and decreased activation in the 11-year-olds as compared to the adult sample. Our results suggest that age-related improvements in the resolution of attention are characterized by an increased use of more functionally specialized brain regions during the course of development. In sum, the present results link the marked development of the resolution of attention to an age-related increase in processing resources. On a neurophysiological level, our findings highlight a role of the saliency network in the context of the resolution of attention. From a developmental perspective, the present results establish that children make use of these circuits from an early age. At the same time, however, children show an increasingly specialized use of these brain regions possibly resulting in the increase in processing resources observed at the behavioral level.', 'Das Ziel der vorliegenden Untersuchung bestand darin, die Entwicklung der Auflösung der Aufmerksamkeit im Kindes- und frühen Jugendalter zu charakterisieren und die der Entwicklung zugrunde liegenden Mechanismen zu untersuchen. Zur Untersuchung dieser Fragestellung wurde das Object-Tracking-Paradigma in zwei Verhaltensexperimenten und einem fMRT-Experiment bei Kindern unterschiedlicher Altersgruppen und bei Erwachsenen verwendet. In der ersten Studie wurden sieben-, neun-, elf- und dreizehnjährigen Kindern sowie Erwachsenen das Object-Tracking-Paradigma mit variierendem Abstand zwischen Zielreiz und Distraktoren dargeboten, um den kritischen Abstand der verschiedenen Altersgruppen bestimmen und den Entwicklungsverlauf des kritischen Abstandes über den beobachteten Altersbereich beschreiben zu können. In diesem Entwicklungsverlauf zeigten sich bedeutsame altersbedingte Veränderungen der Auflösung der Aufmerksamkeit. Der kritische Abstand nahm zwischen 7 und 11 Jahren bedeutend ab, blieb zwischen 11 Jahren und 13 Jahren gleich und sank dann noch einmal bedeutsam zum Erwachsenenalter hin. In einer Kontrollaufgabe konnte gezeigt werden, dass sich die dynamische Sehschärfe im gleichen Alterszeitraum nicht veränderte, woraus geschlossen werden kann, dass die Veränderung der Auflösung der Aufmerksamkeit nicht auf die Entwicklung dieser – der Auflösung der Aufmerksamkeit möglicherweise zugrunde liegenden – visuellen Fähigkeit zurückzuführen ist. In der zweiten Studie wurde in der Object-Tracking-Aufgabe neben dem Abstand zwischen Zielreiz und Distraktoren die Anzahl der Zielreize in zwei Stufen (zwei vs. drei Objekte) variiert. Es zeigte sich hier, dass der kritische Abstand von zwei zu drei Zielreizen über alle Altersgruppen hinweg anstieg. Die Reduktion der pro Zielreiz zur Verfügung stehenden Verarbeitungsressourcen bewirkte somit, dass der Fokus der Aufmerksamkeit weniger eng zusammen gezogen werden konnte. Das Ausmaß des Anstiegs des kritischen Abstandes in den verschiedenen Altersgruppen zeichnete zudem den Entwicklungsverlauf der Auflösung der Aufmerksamkeit in Experiment 1 nach. Das heißt, dass der kritische Abstand von zwei zu drei Objekten bei Kindern stärker als bei Erwachsenen zunahm und innerhalb der Kinderstichproben in den Altersgruppen besonders zunahm, die in Experiment 1 eine geringere Auflösung der Aufmerksamkeit gezeigt hatten. Hieraus lässt sich schließen, dass bei Kindern die Verringerung der pro Objekt zur Verfügung stehenden Verarbeitungsressourcen in besonderem Maße dazu führte, dass sie den Fokus der Aufmerksamkeit weniger eng zusammenziehen konnten. Dies deutet darauf hin, dass die in Experiment 1 beobachtete Entwicklung der Auflösung der Aufmerksamkeit damit im Zusammenhang steht, dass den jüngeren Altersgruppen nicht ausreichend Verarbeitungsressourcen zur Verfügung stehen, um den Aufmerksamkeitsfokus so eng wie Erwachsene zusammenzuziehen. In der dritten Studie wurden die neuronalen Korrelate der Auflösung der Aufmerksamkeit bei sieben- und elfjährigen Kindern und bei Erwachsenen verglichen. Entgegen der Erwartung, dass erhöhte Anforderungen an die Präzision der Selektion mit einer erhöhten Aktivierung der FEF einhergehen würden, führte das Zusammenziehen des Fokus der Aufmerksamkeit zu einem Anstieg der neuronalen Aktivität im Salienznetzwerk aus FIC, ACC und Thalamus. Die Aktivierung dieser Areale wies eine hohe Stabilität zwischen 7 Jahren und dem Erwachsenenalter auf. Gleichzeitig zeigten sich jedoch auch Abweichungen in den Aktivierungsmustern von Kindern und Erwachsenen. Innerhalb des Netzwerkes, das über alle Altersgruppen als Antwort auf erhöhte Anforderungen an die Präzision der Selektion aktiviert wurde, zeigte sich eine altersbedingte Reduktion der Aktivierung im ACC. Daneben wurden zusätzlich entwicklungsbedingte Aktivierungsabweichungen im linken superioren frontalen Gyrus, dem Precuneus, dem posterioren cingulären Gyrus und bilateral im lateralen okzipito-temporalen Kortex sichtbar. Dies deutet darauf hin, dass bei Kindern ein Zusammenziehen des Fokus der Aufmerksamkeit durch Kontrollsignale aus von Erwachsenen abweichenden Arealen geleistet wird. Zusammengenommen deuten die Ergebnisse von Experiment 2 und Experiment 3 darauf hin, dass die Entwicklung der Auflösung der Aufmerksamkeit, die in Experiment 1 für das Schulalter beobachtet werden konnte, auf eine altersbedingte Zunahme der Verarbeitungsressourcen zurückzuführen ist. Auf neuronaler Ebene unterstreichen die vorliegenden Ergebnisse die Bedeutung des Salienznetzwerkes für die Auflösung der Aufmerksamkeit und zeigen, dass dieses Netzwerk ab einem frühen Alter verwendet wird, um die Präzision der Selektion zu erhöhen. Gleichzeitig wird die Verwendung dieses Netzwerkes jedoch mit zunehmendem Alter spezifischer, was möglicherweise dazu führt, dass auf Verhaltensebene eine Zunahme der Verarbeitungsressourcen beobachtet werden kann.']] | ['2014'] | ['http://id.loc.gov/vocabulary/iso639-1/de'] | ['open access'] | [[{'@id': 'gnd:4133279-9'}, {'@id': 'gnd:4068943-8'}]] | ['gnd:4068943-8', 'gnd:4133279-9', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A797480277'] | ['Aufmerksamkeit', 'Kognitive Entwicklung'] | 20 |
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"Hospitals play a major role in research projects on telemonitoring in patients with heart failure. Although the knowledge of its microeconomic consequences present a prerequisite for a sustainable implementation of the service beyond research projects as well as for negotiations on reimbursements, this has not been in the focus of scientific interest so far. It, therefore, is the aim to weigh costs and effects caused by telemonitoring of patients with heart failure from the perspective of a university hospital in a rural area. The interventional costs were determined. Changes in the parameters number of cases, length of hospital stay and number of fused cases due to early rehospitalisation were quantified and monetarily assessed. Differences between intervention and control group from a prospective, randomised and controlled study were taken to quantify the effects. The results of the economic calculation were tested in deterministic sensitivity analyses. Given the current frame conditions and the assumptions made in this calculation, the effects resulting from overseeing patients with heart failure via telemonitoring do not outbalance the costs of the intervention. Although the result appeared to be stable in most of the scenarios tested in the sensitivity analyses, there might be other reasons that should be taken into account when deciding on whether or not to provide this service.",
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} | [] | [] | ['his'] | ['Technische Informationsbibliothek (TIB)'] | [['(isbn)1847011101', '(ppn)799548804', '(isbn)1782044280', '(isbn13)9781847011107', '(ean)9781847011107', '(firstid)BVB:BV042110934']] | ['Currey'] | [['Economic conditions', 'Handelsgeschichte', '(classificationName=linseach:mapping)his', 'Commerce', '(classificationName=bk, id=181569752)15.92 - Afrika südlich der Sahara', '(classificationName=linseach:mapping)sow', '(classificationName=loksys-fbs)Hist 1643', 'Sklaverei', 'Slave trade', '(classificationName=ddc)330.09', '(classificationName=bk, id=181571544)15.30 - Europäische Geschichte in Mittelalter und Neuzeit: Allgemeines', 'History', 'Europa', 'Westafrika', 'Africa, West', 'Economic history', '(classificationName=rvk)LB 50529', '(classificationName=loc)HF3920.Z7', '(classificationName=rvk)NW 8295', '(classificationName=bk, id=106418300)89.91 - Imperialismus', '(classificationName=ddc)382.096604', 'Europe']] | ['Afro-European trade in the Atlantic world : the western Slave Coast, c.1550 - c.1885'] | ['Introduction -- The regional setting -- The Atlantic connection: Little Popo & the rise of Afro-European trade, c. 1600-1702 -- The era of the warrior kings: 1702 to 1772 -- The era of the traders: 1772 to c.1807 -- Disintigration & reconstitution: political developments, 1820s to 1870s -- From slaves to palm oil: Afro-European trade, c.1807 to 1870s -- Epilogue: the colonial partition & its consequences, 1870s to c.1900'] | ['2015'] | ['http://id.loc.gov/vocabulary/iso639-1/en'] | ['commercial licence'] | [''] | ['gnd:120998734', 'gnd:4015701-5', 'gnd:4079203-1', 'gnd:4198287-3', 'https://www.tib.eu/de/suchen/id/TIBKAT%3A799548804'] | ['Strickrodt, Silke', 'Europa', 'Westafrika', 'Sklavenhandel'] | 9 |
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