pubid int32 113k 27.9M | question stringlengths 17 664 | context sequence | long_answer stringlengths 1 3.12k | final_decision stringclasses 2 values | claim stringlengths 17 394 |
|---|---|---|---|---|---|
10,545,320 | Is the Ig fold of the core binding factor alpha Runt domain a member of a family of structurally and functionally related Ig-fold DNA-binding domains? | {
"contexts": [
"CBFA is the DNA-binding subunit of the transcription factor complex called core binding factor, or CBF. Knockout of the Cbfa2 gene in mice leads to embryonic lethality and a profound block in hematopoietic development. Chromosomal disruptions of the human CBFA gene are associated with a large per... | Structural comparisons demonstrate that the s-type Ig fold found in the Runt domain is conserved in the Ig folds found in the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, and the T-domain. Thus, these proteins form a family of structurally and functionally related DNA-binding domains. Unlike the other members of this family, the Runt domain utilizes loops at both ends of the Ig fold for DNA recognition. | yes | The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains. |
26,598,425 | Is medical Expulsive Therapy Underused for the Management of Renal Colic in the Emergency Setting? | {
"contexts": [
"Although the 2007 AUA (American Urological Association) guidelines established it as first line therapy for ureteral stones less than 10 mm, widespread adoption of medical expulsive therapy has been low. We determined the current penetrance of medical expulsive therapy guideline recommendations a... | Medical expulsive therapy for renal colic in the emergency setting remains underused. Half of the patients who met criteria for medical expulsive therapy in this study did not receive the standard of care. Patients treated with medical expulsive therapy achieved spontaneous passage more quickly but there was no difference in the requirement for a urological procedure. These results highlight the need for personnel at emergency departments to better standardize care for patients with ureteral stones. | yes | Medical Expulsive Therapy is underused for the management of renal colic in the emergency setting. |
16,121,981 | Do encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia? | {
"contexts": [
"The authors evaluated the neuroprotective and angiogenic effects of a continuous and low-dose infusion of vascular endothelial growth factor (VEGF)-165 on cerebral ischemia in rats.",
"The authors introduced VEGF complementary (c)DNA into baby hamster kidney (BHK) cells and established a cell... | Continuous intracerebral administration of low-dose VEGF165 through encapsulated grafts of VEGF-producing cells produces neuroprotective and angiogenic effects. These effects improve subsequent motor function. | yes | Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia. |
21,913,968 | Does hbA1c 3 months after diagnosis predict premature mortality in patients with new onset type 2 diabetes? | {
"contexts": [
"To determine 5-year mortality rates, following the diagnosis of Type 2 diabetes, in a large local cohort of individuals with new onset of Type 2 diabetes seen within a few weeks of diagnosis in a single, community-based education programme.",
"We reviewed referrals for people with Type 2 diab... | Our retrospective analysis adds weight to evidence suggesting that referral rates for people with Type 2 diabetes are increasing rapidly and that mortality rates are reducing but that the reasons for this are multifactorial. In addition to blood pressure, smoking and gender, the HbA(1c) achieved 3 months after the initial diagnosis also appears to predict subsequent mortality. It may be appropriate to consider early and intensive intervention for individuals with new onset type 2 diabetes. | yes | HbA1c 3 months after diagnosis predicts premature mortality in patients with new onset type 2 diabetes. |
16,949,519 | Is a common variant in the ACE gene associated with peripheral neuropathy in women with type 2 diabetes mellitus? | {
"contexts": [
"The D allele of the ACE I/D gene variant is associated with higher tissue and serum ACE activity. Previously, studies have suggested an association between the D allele with the microvascular complications of diabetes. The aim of this study was to explore the impact of this genotype in relation t... | The presence of the D allele is associated with increased risk of peripheral neuropathy in females but not in male subjects with type 2 DM, suggesting a role for the renin-angiotensin system in the development of PN. | yes | A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus. |
22,163,269 | Is dietary calcium but not elemental calcium from supplements associated with body composition and obesity in Chinese women? | {
"contexts": [
"We assessed whether dietary calcium intake or calcium supplements associated with body composition and obesity in a Chinese population.",
"A cross-sectional survey was performed in a population of 8940, aged 20 to 74 y. 8127 participants responded (90.9%). Height, weight, fat mass (FM), waist... | Dietary calcium from food rather than elemental calcium from calcium supplements has beneficial effects on the maintenance of body composition and preventing abdominal obesity in Chinese women. | yes | Dietary calcium but not elemental calcium from supplements is associated with body composition and obesity in Chinese women. |
26,253,749 | Do dietary intakes of expeditioners during prolonged sunlight deprivation in polar enviroments support bone health? | {
"contexts": [
"Early Antarctic expeditions were plagued by nutrient deficiencies, due to lack of fresh food and reliance on preserved foods. Modern Antarctic expeditioners also require provisions to be shipped in, but improved knowledge and storage options ensure foods are nutritionally sound. Despite this, nut... | Improving consumption of calcium-rich (dairy) foods better supports bone health during sunlight deprivation. Increasing vegetable intake to recommended levels will increase fibre, potassium and magnesium intakes. The challenge is the logistics of providing these foods throughout the year. | no | Dietary intakes of expeditioners during prolonged sunlight deprivation in polar environments support bone health. |
20,537,867 | Is re-epithelialization from human skin explant cultures promoted by ligand-activated HER3 receptor? | {
"contexts": [
"Ligand-stimulated epidermal growth factor receptor (EGFR/HER1) plays a fundamental role in skin biology as potent transducer of mitotic and anti-apoptotic stimuli in keratinocytes. In human epidermis, at least two additional EGFR family members--HER2 and HER3--are expressed but their biological f... | The study emphasizes the central role of EGFR in epidermal renewal and demonstrates that HRG-activated HER3 contributes to the outgrowth process of epidermis in vitro. | yes | Re-epithelialization from human skin explant cultures is promoted by ligand-activated HER3 receptor. |
15,978,552 | Do alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset? | {
"contexts": [
"Recent findings have demonstrated the familiality of psychotic symptoms occurring during Alzheimer disease (AD with psychosis, AD+P), particularly for subjects with multiple psychotic symptoms. We have proposed a model in which genes that confer a small risk for psychosis interact with neurodegen... | Although limited by small sample size and retrospective design, these data are novel in that they indicate an association of subsyndromal psychotic symptoms before AD onset with psychosis in AD. Subsyndromal psychosis might be useful for classifying AD+P families for genetic mapping studies. Prospective confirmation is required. | yes | Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset. |
23,644,113 | Are [ SIRT1 expression and activity up-regulated in the brain tissue of epileptic patients and rat models ]? | {
"contexts": [
"To investigate the expression and activity of silent information regulator 1 (SIRT1) in the temporal lobe of epileptic patients and rat models and explore its role in the occurrence and progression of epilepsy.",
"The temporal lobe tissue of epileptic patients and rat models (induced by lithi... | Up-regulation of SIRT1 expression and activity in the temporal lobe of epileptic patients and rat models may play an important role in the pathogenesis of epilepsy. | yes | SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models. |
23,880,405 | Is methionine sulfoxide reductase A rs10903323 G/A polymorphism associated with increased risk of coronary artery disease in a Chinese population? | {
"contexts": [
"Coronary artery disease (CAD) is a complex disease resulting from a combination of environmental and genetic factors. We hypothesized that polymorphisms in methionine sulfoxide reductase A (MSRA: rs10903323 G/A) and vascular endothelial growth factor A (VEGFA: rs699947 C/A, rs2010963 G/C, and rs3... | These findings suggest that the functional MSRA rs10903323 G/A polymorphism is associated with CAD development. However, our results allow only a preliminary conclusion, which must be validated with a larger study of a more diverse ethnic population. | yes | Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population. |
27,782,859 | Do mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions? | {
"contexts": [
"In recent years, immunomodulatory mechanisms of mesenchymal stem/stromal cells (MSCs) from bone marrow and other \"classic\" sources have been described. However, the phenotypic and functional properties of tumor MSCs are poorly understood. The aim of this study was to analyze the immunosuppressi... | This study suggests that CeCa-MSCs play an important role in the suppression of the anti-tumor immune response in CeCa through the purinergic pathway. | yes | Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions. |
24,496,038 | Does sR48692 inhibit non-small cell lung cancer proliferation in an EGF receptor-dependent manner? | {
"contexts": [
"The mechanism by which SR48692 inhibits non-small cell lung cancer (NSCLC) proliferation was investigated.",
"The ability of SR48692 to inhibit the proliferation of NSCLC cell lines NCI-H1299 and A549 was investigated in vitro in the presence or absence of neurotensin (NTS). The ability of NT... | These results suggest that SR48692 may inhibit NSCLC proliferation in an EGFR-dependent mechanism. | yes | sR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner. |
10,633,224 | Does leptin increase in vivo GH responses to GHRH and GH-releasing peptide-6 in food-deprived rats? | {
"contexts": [
"Leptin has recently been shown to have a stimulatory effect on basal GH secretion. However, the mechanisms by which leptin exert this effect are not yet clear. GHRH and GH-releasing peptide (GHRP)-6 are the two most potent GH secretagogues described to date.",
"To determine if leptin could al... | These data suggest that the blunted GH response to GHRH and GHRP-6 in food-deprived rats is a functional and reversible state, and that the decreased leptin concentrations could be the primary defect responsible for the altered GH secretion in food-deprived rats. | yes | Leptin increases in vivo GH responses to GHRH and GH-releasing peptide-6 in food-deprived rats. |
17,656,499 | Does sensitivity towards patient need in the occupational health consultation? | {
"contexts": [
"Many employers in Finland provide not only preventive health care but also primary care for their employees. This puts occupational health professionals (OHPs) in a dual role, which in turn raises questions about patient privacy.",
"To investigate occupational health nurses' (n = 140) and phy... | Tact and sensitivity are paramount when dealing with patient privacy. The aim of privacy, however, should not be to conceal information, but rather to prevent any harmful disclosure. | yes | Sensitivity towards patient need exists in the occupational health consultation. |
18,039,385 | Does developmental stage of oligodendrocytes determine their response to activated microglia in vitro? | {
"contexts": [
"Oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes are both lost in central nervous system injury and disease. Activated microglia may play a role in OPC and oligodendrocyte loss or replacement, but it is not clear how the responses of OPCs and oligodendrocytes to activated micro... | Activated microglia may have divergent effects on OPCs and mature oligodendrocytes, reducing OPC survival and increasing mature oligodendrocyte survival. This may be of importance because activated microglia are present in several disease states where both OPCs and mature oligodendrocytes are also reacting to injury. Activated microglia may simultaneously have deleterious and helpful effects on different cells after central nervous system injury. | yes | The developmental stage of oligodendrocytes determines their response to activated microglia in vitro. |
25,585,568 | Is nUSAP1 expression upregulated by loss of RB1 in prostate cancer cells? | {
"contexts": [
"Overexpression of NUSAP1 is associated with poor prognosis in prostate cancer, but little is known about what leads to its overexpression. Based on previous observations that NUSAP1 expression is enhanced by E2F1, we hypothesized that NUSAP1 expression is regulated, at least in part, by loss of R... | Our studies support the notion that NUSAP1 expression is upregulated by loss of RB1 via the RB1/E2F1 axis in prostate cancer cells. Such upregulation may promote prostate cancer progression by increasing proliferation and invasion of prostate cancer cells. NUSAP1 may thus represent a novel therapeutic target. | yes | nUSAP1 expression is upregulated by loss of RB1 in prostate cancer cells. |
18,982,558 | Do [ Protective effects of taurine on myocardial mitochondria and their enzyme activities in rate with severe burn ]? | {
"contexts": [
"To investigate the effects of taurine on myocardial mitochondria and their enzyme activities in rats with severe burn.",
"One hundred and twenty healthy adult Wistar rats were subjected to 30% TBSA full-thickness burn. They were randomly divided into burn group (B, with intraperitoneal inject... | Taurine have protective effect on mitochondria and their enzyme activities in myocardium in rats with severe burn, and it may be attributable to improving the ability of eradicating oxygen free radicals and alleviating Ca2+ overload in the mitochondria. | yes | Taurine has protective effects on myocardial mitochondria and their enzyme activities in rats with severe burn. |
21,732,164 | Is microvessel density but not neoangiogenesis associated with 18F-FDG uptake in human atherosclerotic carotid plaques? | {
"contexts": [
"The vulnerable atherosclerotic lesion exhibits the proliferation of neovessels and inflammation. The imaging modality 2-deoxy-2-[(18)F]fluoro-D: -glucose positron emission tomography ((18)FDG-PET) is considered for the identification of vulnerable plaques.",
"The purpose of this study was to ... | Neoangiogenesis is not associated with (18)FDG uptake, whereas MVD and markers of vulnerability correlate with (18)FDG uptake. The absence of correlation between markers of neoangiogenesis and (18)FDG uptake suggests a temporal separation between the process of neoangiogenesis and inflammatory activity. | yes | Microvessel density, but not neoangiogenesis, is associated with 18F-FDG uptake in human atherosclerotic carotid plaques. |
16,505,298 | Is left insular stroke associated with adverse cardiac outcome? | {
"contexts": [
"After stroke, 10% of patients have adverse cardiac outcomes. Left insular damage may contribute to this by impairing sympathovagal balance (associated with cardiac structural damage and arrhythmias).",
"The authors conducted a prospective study of 32 patients with left insular stroke (Group 1... | Left insular stroke is associated with an increased risk of adverse cardiac outcome and decreased cardiac wall motion compared to stroke in other locations and TIA. This was particularly marked in patients without symptomatic coronary artery disease (SCAD). In patients with SCAD, the cardioprotective effect of medications, especially beta-blockers alone or combined with ischemic preconditioning, may explain the lack of association in this subgroup. | yes | Left insular stroke is associated with adverse cardiac outcome. |
22,270,983 | Is invasion of the hepatic artery a crucial predictor of poor outcomes in gallbladder carcinoma? | {
"contexts": [
"In the present study we undertook a retrospective analysis of gallbladder carcinoma to assess whether histologically determined hepatic artery (HA) invasion and portal vein (PV) invasion can be considered prognostic factors.",
"Seventy-one patients who had undergone radical resection for gall... | Invasion of the HA is a crucial prognostic factor in patients with gallbladder carcinoma. | yes | Invasion of the hepatic artery is a crucial predictor of poor outcomes in gallbladder carcinoma. |
21,997,784 | Are all-polyethylene and metal-backed tibial components equivalent with BMI of less than 37.5? | {
"contexts": [
"Modular, metal-backed tibial (MBT) components are associated with locking mechanism dysfunction, breakage, backside wear, and osteolysis, which compromise survivorship. All-polyethylene tibial (APT) components eliminate problems associated with MBTs, but, historically, APT utilization has general... | APT implants perform as well as MBT implants in a non-age- or activity-selected TKA population with a BMI of less than 37.5. | yes | All-polyethylene and metal-backed tibial components are equivalent with a BMI of less than 37.5. |
19,704,065 | Do professionals assess the acceptability of preimplantation genetic diagnosis and prenatal diagnosis for managing inherited predisposition to cancer? | {
"contexts": [
"Preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) practices for inherited predisposition to cancer are heterogeneous in industrialized countries. In France, permission to perform PGD/PND must be obtained from registered Multidisciplinary Prenatal Diagnosis Teams (MPDTs). The ai... | With the most severe forms of inherited cancer, no differences were observed between the acceptability to practitioners of PND and PGD, but with late-onset syndromes, there is still much uncertainty. Guidelines would help to standardize the practices of professionals handling these reproductive issues. | yes | Professionals assess the acceptability of preimplantation genetic diagnosis and prenatal diagnosis for managing inherited predisposition to cancer. |
11,003,210 | Does chronic ethanol consumption alter recovery of spontaneously active medial septal/diagonal band of broca neurons from GABA-microiontophoresis? | {
"contexts": [
"Acute ethanol administration increases GABA-mediated inhibition in a variety of cerebral cortical preparations. Furthermore, chronic ethanol administration blunts ethanol-induced increases in GABA-mediated inhibition and alters GABA A receptor subunit mRNA and peptide expression in the cerebral c... | Chronic ethanol consumption alters the frequency of spontaneous MS/DB neural activity following GABA microiontophoresis compared to premicroiontophoresis levels. These data suggest that the kinetics of GABA A receptors in the MS/DB are altered by chronic ethanol consumption independent of changes in the total amount of inhibition or alterations in GABA A receptor alpha1 and alpha4 subunit peptide expression. | yes | Chronic ethanol consumption alters recovery of spontaneously active medial septal/diagonal band of broca neurons from GABA-microiontophoresis. |
10,477,908 | Does `` Decoy '' of androgen-responsive element induce apoptosis in LNCaP cells? | {
"contexts": [
"In an androgen-dependent manner, the androgen receptor (AR) binds to the androgen-responsive element (ARE) in the regulatory region of target genes. We hypothesize that an \"ARE decoy, \" a double-stranded oligonucleotide containing the same DNA sequence as ARE, can inhibit prostatic proliferatio... | The ARE decoy had an antiandrogen effect and induced apoptosis in LNCaP cells. This ARE decoy may become a potential therapeutic tool for prostate cancers when combined with a highly efficient transfection method. | yes | The "Decoy" of androgen-responsive element induces apoptosis in LNCaP cells. |
20,128,962 | Does [ Huangqi decoction inhibit cholangiocyte proliferation and transdifferentiation in cholestatic liver fibrosis induced by BDL in rats ]? | {
"contexts": [
"To elucidate the antifibrotic mechanism of Huangqi decoction in rats with BDL-induced cholestatic liver fibrosis.",
"Liver fibrosis model was induced by ligating the common bile duct (BDL) in rats. Sham-operation was performed in control rats. The BDL rats were randomly divided into two group... | These observations suggest that Huangqi decoction can inhibit cholangiocyte proliferation and cholangiocyte transdifferentiation. | yes | Huangqi decoction inhibits cholangiocyte proliferation and transdifferentiation in cholestatic liver fibrosis induced by BDL in rats. |
26,177,272 | Is diabetic nephropathy an independent factor associated to severe subclinical atheromatous disease? | {
"contexts": [
"Atheromatous disease (AD) is a risk factor for death in renal patients. Traditional CV risk factors do not predict the presence of AD in this population. The aim of this study is to analyze whether the etiology of the primary renal disease influences in the risk of having silent AD.",
"Observ... | Observational study with the potential for confounding. | yes | Diabetic nephropathy is an independent factor associated with severe subclinical atheromatous disease. |
21,189,857 | Does awareness among resident doctors with regard to cardiac defibrillators? | {
"contexts": [
"Electrical defibrillation is the most important therapy for patients in cardiac arrest. The audit was aimed to assess awareness among residents with respect to routine preuse checking of cardiac defibrillators.",
"The audit was conducted at a multispeciality tertiary care referral and teachin... | All medical equipment is to be tested prior to initial use and periodically thereafter. An extensive, recurring training program, and continued attention to the training of clinical personnel is required to ensure that they are proficient in the operation and testing of specific defibrillator models in their work area. We conclude that apart from awareness of the use of the equipment we are using, its preuse testing is must. All resident doctors should be aware of the presence and adequate functioning of the defibrillator in their ORs and this audit reinforces the need for training of all resident doctors. | yes | Awareness among resident doctors exists with regard to cardiac defibrillators. |
21,140,080 | Is morphofunctional malignancy grading a valuable prognostic factor for colorectal cancer? | {
"contexts": [
"Novel strategies are needed to identify more efficient biomarkers to accurately diagnose prognose and improve the treatment outcome of colorectal cancer.",
"To analyze the functional and morphological features of colorectal cancer to identify the neoplastic patterns that affect patient surviv... | Morphofunctional staging is a valuable prognostic factor for colorectal cancer and it correlates with plasma CEA levels. | yes | Morphofunctional malignancy grading is a valuable prognostic factor for colorectal cancer. |
19,208,226 | Does rhombomere-specific analysis reveal the repertoire of genetic cues expressed across the developing hindbrain? | {
"contexts": [
"The Hox family of homeodomain transcription factors comprises pivotal regulators of cell specification and identity during animal development. However, despite their well-defined roles in the establishment of anteroposterior pattern and considerable research into their mechanism of action, relati... | We have performed a systematic survey of the transcriptional status of individual segments of the developing mouse hindbrain and identified hundreds of previously undescribed genes expressed in this region. The functional range of the potential candidate effectors or upstream modulators of Hox activity suggest multiple unexplored mechanisms. In particular, we present evidence of a potential new retinoic acid signalling system in ventral r4 and propose a model for the refinement of identity in this region. Furthermore, the rhombomeres demonstrate a molecular relationship to each other that is consistent with known observations about neurogenesis in the hindbrain. These findings give the first genome-wide insight into the complexity of gene expression during patterning of the developing hindbrain. | yes | Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. |
25,723,531 | Does promoter hypermethylation-related reduced somatostatin production promote uncontrolled cell proliferation in colorectal cancer? | {
"contexts": [
"Somatostatin (SST) has anti-proliferative and pro-apoptotic effects. Our aims were to analyze and compare the SST expression during normal aging and colorectal carcinogenesis at mRNA and protein levels. Furthermore, we tested the methylation status of SST in biopsy samples, and the cell growth in... | In cancerous colonic mucosa the reduced SST production may contribute to the uncontrolled cell proliferation. Our observation that in colon cancer cells octreotide significantly enhanced cell death and attenuated cell proliferation suggests that SST may act as a regulator of epithelial cell kinetics. The inhibition of SST expression in CRC can be epigenetically regulated by promoter hypermethylation. | yes | Promoter hypermethylation-related reduced somatostatin production promotes uncontrolled cell proliferation in colorectal cancer. |
15,093,887 | Is myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate , partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway? | {
"contexts": [
"We sought to clarify that a peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activator inhibits myocardial fibrosis and its resultant diastolic dysfunction in hypertensive heart disease, as well as to investigate whether inflammatory mediators through the nuclear factor (NF)-kappa-B ... | A PPAR-alpha activator reduced myocardial fibrosis and prevented the development of diastolic dysfunction in DOCA-salt rats. The effects of a PPAR-alpha activator may be mediated partly by prevention of inflammatory mediators through the NF-kappa-B pathway. These results suggest that treatment with PPAR-alpha activators will improve diastolic dysfunction in hypertensive heart disease. | yes | Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. |
25,594,059 | Are epidermal growth factor receptor ( EGFR ) mutations exceptionally rare in thyroid transcription factor ( TTF-1 ) -negative adenocarcinomas of the lung? | {
"contexts": [
"Approximately 70% of lung adenocarcinomas express TTF-1. EGFR mutations are present in 13-15% of Western adenocarcinoma patients. This paper investigates TTF1 as a negative predictor of mutant EGFR in lung adenocarcinomas.",
"In the pilot cohort (N = 301) two of 224 specimens positive for EGF... | An overwhelming majority of TTF-1 negative adenocarcinomas will be negative for EGFR mutations. This finding allows for earlier initiation of chemotherapy in newly diagnosed TTF-1 negative adenocarcinomas of the lung with stage IV disease. | yes | Epidermal growth factor receptor ( EGFR ) mutations are exceptionally rare in thyroid transcription factor ( TTF-1 ) -negative adenocarcinomas of the lung. |
27,466,989 | Is the expression of inhibitor of growth 4 reduced in cervical cancer tissues? | {
"contexts": [
"Inhibitor of growth 4 (ING4) is a candidate tumor suppressor which plays an important role in multiple processes including DNA repair, apoptosis, cell cycle control, tumor metastasis and angiogenesis. However, clinical data about the role of ING4 in the development and progression of cervical can... | ING4 expression is decreased in human cervical cancer tissues. Reconstitution of ING4 expression in cervical cancer cells is correlated with decreased HPV E6/E7 transcription. These data suggest that ING4 expression has diagnostic and prognostic significance for cervical cancer. | yes | The expression of inhibitor of growth 4 is reduced in cervical cancer tissues. |
25,011,684 | Is histone deacetylase 8 deregulated in urothelial cancer but not a target for efficient treatment? | {
"contexts": [
"Previous studies have shown that class-I histone deacetylase (HDAC) 8 mRNA is upregulated in urothelial cancer tissues and urothelial cancer cell lines compared to benign controls. Using urothelial cancer cell lines we evaluated whether specific targeting of HDAC8 might be a therapeutic option in... | Deregulation of HDAC8 is frequent in urothelial cancer, but neither specific pharmacological inhibition nor siRNA-mediated knockdown of HDAC8 impaired viability of urothelial cancer cell lines in a therapeutic useful manner. Accordingly, HDAC8 on its own is not a promising drug target in bladder cancer. | yes | Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment. |
23,919,964 | Is concomitant high-grade prostatic intraepithelial neoplasia associated with good prognosis factors and oncologic outcome after radical prostatectomy? | {
"contexts": [
"To assess correlations between concomitant high-grade prostatic intraepithelial neoplasia (HGPIN), pathological features and oncologic outcomes after radical prostatectomy (RP).",
"We prospectively collected a single-institution database of 2,351 patients who underwent RP between 1998 and 201... | HGPIN is associated with factors of good prognosis but fails to show independent significance when classical pathological prognostic factors are taken into account. | yes | Concomitant high-grade prostatic intraepithelial neoplasia is associated with good prognosis factors and oncologic outcome after radical prostatectomy. |
24,752,159 | Is surgical strategy for the gastric gastrointestinal stromal tumors ( GISTs ) larger than 5 cm : laparoscopic surgery feasible , safe , and oncologically acceptable? | {
"contexts": [
"The efficacy and feasibility of laparoscopic surgery (LAP) for gastric GISTs >5 cm has not been adequately assessed. Here we investigated the clinical outcomes of these patients.",
"Twenty-seven consecutive patients who underwent resection for gastric GISTs >5 cm were enrolled in this retrosp... | In patients with gastric GISTs >5 cm, LAP can be performed with outcomes equivalent to those of OPEN if patient selection and intraoperative judgment are appropriate. | yes | Surgical strategy for the gastric gastrointestinal stromal tumors ( GISTs ) larger than 5 cm is laparoscopic surgery feasible, safe, and oncologically acceptable. |
21,234,586 | Is c-Jun N-terminal kinase involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells? | {
"contexts": [
"To determine the presence of integrin-linked kinase (ILK) in tissue samples of retinoblastoma patients, and to explore the function of ILK in human Y79 retinoblastoma cells.",
"The expression of ILK was studied in samples of retinoblastoma patients by immunohistochemistry. In vitro, specific ... | Our results demonstrated that ILK promoted proliferation and suppressed apoptosis via repressing phosphorylations of the JNK signal pathway in human retinoblastoma cells. This might provide a potential therapeutic target in the treatment of this deadly disease. | yes | C-Jun N-terminal kinase is involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells. |
24,684,825 | Are markers of endothelial cell dysfunction increased in human omental adipose tissue from women with pre-existing maternal obesity and gestational diabetes? | {
"contexts": [
"To determine the effect of maternal obesity and gestational diabetes mellitus (GDM) on the expression and release of genes involved in endothelial cell dysfunction in human placenta and omental adipose tissue.",
"Human placenta and omental adipose tissue were obtained from non-obese and obese... | This study demonstrated the presence of abnormal expression and secretion of angiogenic proteins and adhesion molecules in omental adipose tissue, but not placenta, from pregnant women with GDM and pre-existing maternal obesity. Increased angiogenic and adhesion molecules released from adipose tissue may affect angiogenesis, inflammation and or lipid and glucose metabolism in both mum and her offspring. | yes | Markers of endothelial cell dysfunction are increased in human omental adipose tissue from women with pre-existing maternal obesity and gestational diabetes. |
23,077,439 | Does endocrine therapy initiation from 2001 to 2008 vary by age at breast cancer diagnosis and tumor size? | {
"contexts": [
"To evaluate tamoxifen and aromatase inhibitor (AI) initiation over time and by patient characteristics among women diagnosed with breast cancer in a community setting.",
"We conducted a retrospective cohort study of 1,501 women age ≥ 18 years diagnosed with stages I to II invasive, hormone re... | Differential initiation over time, as well as by age and tumor size, suggests patient preferences and provider recommendations for endocrine therapy vary, despite guideline recommendations. | yes | Endocrine therapy initiation from 2001 to 2008 varies by age at breast cancer diagnosis and tumor size. |
26,362,483 | Are changes in the amino acid sequence of the recombinant human factor VIIa analog , vatreptacog alfa , associated with clinical immunogenicity? | {
"contexts": [
"Vatreptacog alfa, a recombinant human factor VIIa (rFVIIa) analog developed to improve the treatment of bleeds in hemophilia patients with inhibitors, differs from native FVIIa by three amino acid substitutions. In a randomized, double-blind, crossover, confirmatory phase III trial (adept(™) 2), ... | Results from the vatreptacog alfa phase III trial demonstrate that the specific changes made, albeit relatively small, to the FVIIa molecule alter its clinical immunogenicity. | yes | Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity. |
26,839,445 | Does postoperative CA19-9 Change be a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection? | {
"contexts": [
"To investigate the clinical significance of the perioperative CA19-9 change for predicting survival in intrahepatic cholangiocarcinoma (ICC) patients treated with surgical resection.",
"We retrospectively reviewed the data from 74 ICC patients treated with surgical resection between April 200... | Patients who have normalized CA19-9 levels postoperatively have longer survival outcomes. Therefore, normalized postoperative CA19-9 may be a useful clinical marker for ICC survival. | yes | Postoperative CA19-9 change is a useful predictor of intrahepatic cholangiocarcinoma survival following liver resection. |
24,342,144 | Is alvimopan , a peripherally acting μ-opioid receptor antagonist , associated with reduced costs after radical cystectomy : economic analysis of a phase 4 randomized , controlled trial? | {
"contexts": [
"We evaluated the effect of alvimopan treatment vs placebo on health care utilization and costs related to gastrointestinal recovery in patients treated with radical cystectomy in a randomized, phase 4 clinical trial.",
"Resource utilization data were prospectively collected and evaluated by c... | In patients treated with radical cystectomy alvimopan decreased hospitalization cost by reducing the health care services associated with postoperative ileus and decreasing the hospital stay. | yes | Alvimopan, a peripherally acting μ-opioid receptor antagonist, is associated with reduced costs after radical cystectomy: economic analysis of a phase 4 randomized, controlled trial. |
20,141,577 | Is class II beta-tubulin a novel marker for human tonsillar M cells and follicular dendritic cells? | {
"contexts": [
"Membranous (M) cell of the human palatine tonsil is an antigen entry site for mucosal infection, but its location is obscure in histological sections. Recently, a microarray analysis has demonstrated that clusterin, annexin A5, CD44, MMP14, and beta-tubulin are candidate genes of M cell marker in... | Class II beta-tubulin is a specific histochemical marker for human tonsillar M cells and FDCs. Thus, class II beta-tubulin immunostaining may be useful to identify tonsillar M cells and to diagnose FDC proliferative lesions such as AILT. | yes | Class II beta-tubulin is a novel marker for human tonsillar M cells and follicular dendritic cells. |
21,703,985 | Is bid a positive regulator for donor-derived lymphoid cell regeneration in γ-irradiated recipients? | {
"contexts": [
"Hematopoietic regeneration is regulated by cell survival proteins, such as the Bcl-2 family. Bid, a BH3-only protein of the Bcl-2 family, has multiple cellular functions and is involved in a variety of physiological or pathological conditions. We attempted to define its role in hematopoietic cell... | Our current study demonstrates a positive impact of Bid on hematopoietic regeneration mainly due to its unique effects on donor lymphopoiesis in the transplant recipients. | yes | Bid is a positive regulator for donor-derived lymphoid cell regeneration in γ-irradiated recipients. |
22,278,419 | Is cLM94 , a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties , active against primary anaplastic thyroid cancer in vitro and in vivo? | {
"contexts": [
"We have studied the antitumor activity of a novel cyclic amide, CLM94, with anti-vascular endothelial growth factor (VEGF) receptor-2 and antiangiogenic activity in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo.",
"CLM94 was tested: 1) in two human cell lines (HMVEC-d, de... | The antitumor and antiangiogenic activity of a new "cyclic amide" compound, CLM94, is very promising in ATC, opening the way to a future clinical evaluation. | yes | cLM94, a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo. |
22,042,947 | Does mET amplification identify a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib? | {
"contexts": [
"Amplification of the MET proto-oncogene in gastroesophageal cancer (GEC) may constitute a molecular marker for targeted therapy. We examined a GEC cohort with follow-up and reported the clinical response of four additional patients with MET-amplified tumors to the small molecule inhibitor crizoti... | MET amplification defines a small and aggressive subset of GEC with indications of transient sensitivity to the targeted MET inhibitor crizotinib (PF-02341066). | yes | mET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. |
22,923,671 | Is serum cathepsin S associated with decreased insulin sensitivity and the development of type 2 diabetes in a community-based cohort of elderly men? | {
"contexts": [
"To investigate associations between serum cathepsin S, impaired insulin sensitivity, defective insulin secretion, and diabetes risk in a community-based sample of elderly men without diabetes.",
"Serum cathepsin S, insulin sensitivity (euglycemic-hyperinsulinemic clamp), and insulin secretion... | Cathepsin S activity appears to be involved in the early dysregulation of glucose and insulin metabolism. | yes | Serum cathepsin S is associated with decreased insulin sensitivity and the development of type 2 diabetes in a community-based cohort of elderly men. |
21,746,728 | Does sensitivity to secondhand smoke exposure predict future smoking susceptibility? | {
"contexts": [
"Susceptibility to cigarette smoking in tobacco-naive youth is a strong predictor of smoking initiation. Identifying mechanisms that contribute to smoking susceptibility provide information about early targets for smoking prevention. This study investigated whether sensitivity to secondhand smoke ... | Assessment of SHSe sensitivity is a novel approach to the study of cigarette initiation etiology and informs prevention interventions. | yes | Sensitivity to secondhand smoke exposure predicts future smoking susceptibility. |
20,007,909 | Does a specific subset of mouse bone marrow cells have smooth muscle cell differentiation capacity-brief report? | {
"contexts": [
"To determine whether CX(3)CR1(+) bone marrow cells have the capacity for smooth muscle cell (SMC) differentiation.",
"CX(3)CR1(+) and CX(3)CR1(-) cells were isolated from marrow of CX(3)CR1 transgenic mice and cultured in SMC differentiation media. Phenotypic and functional analyses showed on... | CX(3)CR1 marks a bone marrow cells population that enriches for progenitors with capacity to differentiate in vitro into SMC-like cells. | yes | A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity. |
26,183,043 | Is hand-held echocardiography useful for diagnosis of left systolic dysfunction in an elderly population? | {
"contexts": [
"Hand-held echocardiography (echo) (HE) was compared with standard echo (SE) to evaluate the quality of HE and to determine if it is safe to use HE to screen for left ventricular systolic dysfunction (LVSD) in the elderly.",
"A total of 260 high-risk persons aged 75 years and older with and wi... | According to this study, HE is a valuable tool to screen for LVSD and other changes in cardiac function and morphology in a high-risk population aged 75+ years; nothing very important is missed by HE and the experienced echocardiographers; and in case of a normal HE, it is safe not to refer to SE. | yes | Hand-held echocardiography is useful for diagnosis of left systolic dysfunction in an elderly population. |
25,219,757 | Do bilingual flipcharts help improve oral health-related knowledge and self-efficacy of Korean-American caregivers of preschoolers? | {
"contexts": [
"We have limited knowledge on ways to improve oral health-related behaviors for caregivers of minority preschoolers. Our objective was to evaluate the effectiveness of a bilingual educational flipchart.",
"We piloted a bilingual flipchart with Korean-American caregivers of preschoolers (n=219)... | Bilingual educational materials help improve the oral health-related knowledge and self-efficacy of Korean-American caregivers of preschoolers. Larger confirmatory studies are needed and future work should evaluate clinical outcomes associated with improved knowledge and self-efficacy. | yes | Bilingual flipcharts help improve oral health-related knowledge and self-efficacy of Korean-American caregivers of preschoolers. |
21,543,518 | Does intratumoral administration of TLR4 agonist absorbed into a cellular vector improve antitumor responses? | {
"contexts": [
"Because toll-like receptor (TLR) agonists have been well characterized as dendritic cell (DC) activators, we hypothesized that the admixture of TLR4 agonist into a cellular vector could improve the antitumor response in vivo.",
"Granulocyte macrophage colony stimulating factor secreting whole... | TLR4 on antigen-presenting cells in the tumor microenvironment may be targeted by using cell-based vectors for improved antitumor response in vivo. | yes | Intratumoral administration of TLR4 agonist absorbed into a cellular vector improves antitumor responses. |
26,218,381 | Does chronic Otitis Media with Effusion be Associated with Increased Risk of Secondary Speech Surgery? | {
"contexts": [
"Velopharyngeal insufficiency and chronic otitis media with effusion following primary cleft palate repair can be attributed to persistent abnormalities in the levator and tensor veli palatini muscles, respectively. The purpose of this case-control study was to examine the association between otit... | The authors demonstrate that chronic otitis media with effusion requiring two or more myringotomy tube procedures is associated with a significantly increased likelihood of requiring secondary speech surgery. Using otitis media with effusion as a clinical predictor for secondary velopharyngeal insufficiency could lead to early identification of at-risk patients in need of intensive speech therapy and timely secondary speech surgery. | yes | Chronic Otitis Media with Effusion is associated with an increased risk of secondary speech surgery. |
18,538,501 | Is neoadjuvant radiation associated with improved survival in patients with resectable pancreatic cancer : an analysis of data from the surveillance , epidemiology , and end results ( SEER ) registry? | {
"contexts": [
"Cancer of the exocrine pancreas is the fifth leading cause of cancer death in the United States. Neoadjuvant chemoradiation has been investigated in several trials as a strategy for downstaging locally advanced disease to resectability. The aim of the present study is to examine the effect of neo... | This analysis of SEER data showed a survival benefit for the use of neoadjuvant RT over surgery alone or surgery with adjuvant RT in treating pancreatic cancer. Therapeutic strategies that use neoadjuvant RT should be further explored for patients with resectable pancreatic cancer. | yes | Neoadjuvant radiation is associated with improved survival in patients with resectable pancreatic cancer: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) registry. |
25,771,248 | Do linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway? | {
"contexts": [
"Linalool and β-pinene are two volatile monoterpenes that possess antidepressant-like activity. These are components of many aromatic plants used in folk medicine around the world to relieve anxiety and depression. In this contribution, we focused on examining the mechanism of action of these comp... | Our results indicate that linalool and β-pinene produce an antidepressant-like effect through interaction with the monoaminergic system. | yes | Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway. |
22,036,936 | Is high level of PTEN expression associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer? | {
"contexts": [
"We investigated PTEN expression in primary pancreatic cancer and pancreatic cancer liver metastasis in order to evaluate the interrelationship between PTEN expression and clinicopathological characteristics of pancreatic cancer patients with and without liver metastasis.",
"Eighty five primar... | Our results suggest that a high level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer. The diagnostic evaluation of PTEN expression may provide valuable prognostic information to aid treatment strategies for pancreatic cancer patients. | yes | High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer. |
18,194,100 | Is parvovirus B19 infection in children with acute lymphoblastic leukemia associated with cytopenia resulting in prolonged interruptions of chemotherapy? | {
"contexts": [
"Parvovirus B19 infection causes severe cytopenia and can mimic a leukemic relapse or therapy-induced cytopenia in patients with hematologic malignancies. We evaluated the complications of parvovirus B19 infection, including delays in the scheduled course of chemotherapy, in children with acute ly... | Children with ALL who were infected with parvovirus B19 became cytopenic, leading to reduced treatment intensity and to complications during treatment. Screening for parvovirus B19 DNA by quantitative polymerase chain reaction in pediatric patients with ALL and unexplained cytopenia is suggested. | yes | Parvovirus B19 infection in children with acute lymphoblastic leukemia is associated with cytopenia resulting in prolonged interruptions of chemotherapy. |
24,841,704 | Is diabetes mellitus an independent prognostic factor for major liver-related outcomes in patients with cirrhosis and chronic hepatitis C? | {
"contexts": [
"In patients with chronic hepatitis C (CHC), cirrhosis is associated with age, gender, diabetes, alcohol abuse, and coinfection with human immunodeficiency virus (HIV) or hepatitis B virus (HBV). The effect of these factors on the outcome of cirrhosis is unknown. This study in CHC patients with ci... | In patients with CHC and cirrhosis, diabetes is an independent prognostic factor. Improving diabetes control may improve the outcome of cirrhosis. | yes | Diabetes mellitus is an independent prognostic factor for major liver-related outcomes in patients with cirrhosis and chronic hepatitis C. |
11,341,635 | Does prevention of abdominal adhesions interfere with jejunal anastomosis healing? | {
"contexts": [
"To determine the prevention of adhesions interferes with the healing of jejunal anastomosis.",
"Twenty-five rats allocated into five groups.",
"Group 1- intraperitoneal injection of 12ml-1% sodium carboxymethylcellulose (SCMC). Groups 2-5- jejunal anastomosis. Groups 3 and 5- intraperiton... | The prevention of adhesions not only did not interfere with jejunal anastomotic resistance, but also improved the intestinal healing in the rat. | no | Prevention of abdominal adhesions interferes with jejunal anastomosis healing. |
27,617,438 | Do angiopoetin-2 Signals Mediate the Hypervascularization of Islets in Type 2 Diabetes? | {
"contexts": [
"Changes in the islet vasculature have been implicated in the regulation of β-cell survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to compensate for the increased insulin demand in obesity eventually leads to diabetes; as a result of the complex interpl... | Islet hypervascularization occurs in T2D. A balanced expression of the Ang1/Ang2 system is important for islet physiology. Ang-2 prevents β-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis. | no | Angiopoetin-2 signals mediate the hypervascularization of islets in type 2 diabetes. |
19,594,767 | Is spitz naevus rare in Korea? | {
"contexts": [
"Spitz naevi have not been widely studied in Asians.",
"To compare the epidemiology and clinicopathological features of Spitz naevi in Koreans with lesions in western countries.",
"In total, 80 Spitz naevi in 77 patients diagnosed over 10 years at 17 university hospitals in Korea were anal... | Spitz naevus is rare in Korea. The lesions were more commonly larger, pigmented, and of the dermal type than reported in western countries. | yes | Spitz naevus is rare in Korea. |
21,717,167 | Is uterus didelphys with unilateral vaginal atresia : multicystic dysplastic kidney the precursor of `` renal agenesis '' and the key to early diagnosis of this genital anomaly? | {
"contexts": [
"Uterus didelphys with obstructed hemivagina (UDWOH) and ipsilateral renal agenesis is a distinct but rare entity.",
"To demonstrate the association between UDWOH and a multicystic dysplastic kidney (MCDK) in neonates. To demonstrate the usefulness of sonography with vaginal fluid instillation... | MCDK is key to the early diagnosis of UDWOH and will facilitate the provision of appropriate treatment. The neonatal period provides a unique opportunity for detecting uterine anomalies by sonography. An MCDK usually involutes and eventually mimics renal agenesis later in life. | yes | Uterus didelphys with unilateral vaginal atresia : multicystic dysplastic kidney is the precursor of "renal agenesis" and the key to early diagnosis of this genital anomaly. |
18,301,195 | Is intracranial pressure monitoring in brain-injured patients associated with worsening of survival? | {
"contexts": [
"The Brain Trauma Foundation (BTF) recommends intracranial pressure (ICP) monitoring in traumatic brain injury (TBI) patients with Glasgow Coma Scale (GCS) of 8 or less, and an abnormal brain computed tomography. However, benefits of ICP monitoring have not been documented. We hypothesized that BT... | ICP monitoring in accordance with current BTF criteria is associated with worsening of survival in TBI patients. A prospective randomized controlled trial of ICP-guided therapy is needed. Until then, the use of ICP monitoring should not be used as a quality benchmark. | yes | Intracranial pressure monitoring in brain-injured patients is associated with worsening of survival. |
19,088,021 | Do dNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers? | {
"contexts": [
"About 15% of colorectal cancers harbor microsatellite instability (MSI). MSI-associated gene expression changes have been identified in colorectal cancers, but little overlap exists between signatures hindering an assessment of overall consistency. Little is known about the causes and downstream ... | Our results show cross-study consistency of MSI-associated gene expression changes in colorectal cancers. DNA copy-number alterations partly cause the differences in gene expression between MSI and MSS cancers. | yes | DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers. |
16,195,665 | Does melatonin administration acutely decrease the diffusing capacity of carbon monoxide in human lungs? | {
"contexts": [
"Most physiological measurements of the pulmonary diffusing capacity use carbon monoxide (CO) as a tracer gas. Similar to CO, melatonin binds the hemoglobin in the blood.",
"The present study was designed to assess the effect of exogenous melatonin administration on pulmonary functions includi... | In healthy subjects, oral administration of melatonin acutely influences the DL(CO) without affecting other pulmonary function test results. We conclude that melatonin may have a reducing effect on the DL(CO) in the lungs. | yes | Melatonin administration acutely decreases the diffusing capacity of carbon monoxide in human lungs. |
22,053,725 | Are the chemokine receptor CXCR4 and its ligand CXCL12 activated during implantation and placentation in sheep? | {
"contexts": [
"The progression of implantation and placentation in ruminants is complex and is regulated by interplay between sex steroids and local signaling molecules, many of which have immune function. Chemokines and their receptors are pivotal factors in implantation and vascularization of the placenta. Ba... | A comprehensive analysis of CXCL12 and CXCR4 expression in fetal and maternal tissues during early pregnancy is reported with noteworthy differences occurring during implantation and placentation in sheep. We interpreted these data to mean that the CXCL12/CXCR4 pathway is activated during implantation and placentation in sheep and is likely playing a role in the communication between trophoblast cells and the maternal endometrium. | yes | The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep. |
11,240,956 | Is intradermal administration of a killed Mycobacterium vaccae suspension ( SRL 172 ) associated with improvement in atopic dermatitis in children with moderate-to-severe disease? | {
"contexts": [
"Although a doubling in the prevalence of atopic disease, including atopic dermatitis, in the Western world over the last few generations has been paralleled by a marked reduction in infectious diseases, especially tuberculosis, it is unclear whether this increase in atopy is causally related to r... | SRL 172 was associated with an improvement in the severity of the dermatitis in children with moderate-to-severe disease. | yes | Intradermal administration of a killed Mycobacterium vaccae suspension ( SRL 172 ) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease. |
9,690,539 | Is kAI1/CD82 expression in nonsmall cell lung carcinoma a novel , favorable prognostic factor : an immunohistochemical analysis? | {
"contexts": [
"The KAI1/CD82 gene, the product of which is a member of the transmembrane-4 superfamily, is a suppressor of metastasis; as a result, it is inversely associated with tumor progression and is a favorable prognostic factor in some tumors. This study was performed to determine the prognostic value of... | The immunohistochemically determined level of KAI1/CD82 expression in NSCLC cells within tumor tissue appears to be a favorable prognostic factor for overall survival as well as DFS. The results of this study suggest that decreased KAI1/CD82 expression may be associated with tumor progression and enhanced metastatic potential in some patients with this disease. | yes | kAI1/CD82 expression in nonsmall cell lung carcinoma is a novel, favorable prognostic factor: an immunohistochemical analysis. |
18,061,070 | Does oxidative inhibition of the mitochondrial aldehyde dehydrogenase promote nitroglycerin tolerance in human blood vessels? | {
"contexts": [
"We tested the hypothesis of whether an inhibition of the nitroglycerin (GTN) bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) contributes to GTN tolerance in human blood vessels.",
"The hemodynamic effects of GTN are rapidly blunted by the development of tolerance, a phenome... | Long-term GTN treatment induces tolerance and endothelial dysfunction in human vessels, associated with an inhibition and down-regulation of vascular ALDH-2. Thus, these findings extend results of previous animal studies to humans. | yes | Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels. |
16,600,227 | Is use of a medium buffered with N-hydroxyethylpiperazine-N-ethanesulfonate ( HEPES ) in intracytoplasmic sperm injection procedures detrimental to the outcome of in vitro fertilization? | {
"contexts": [
"This study was conducted to determine whether N-hydroxyethylpiperazine-N-ethanesulfonate (HEPES)-buffered medium used for the microinjection of sperm into oocytes may be detrimental for the embryo.",
"Controlled randomized study.",
"Private IVF center.",
"Women (n = 708) undergoing IC... | Our study showed that the use of media buffered with HEPES, during the microinjection of sperm into the oocytes, is detrimental for IVF outcome and should be avoided. | yes | The use of a medium buffered with N-hydroxyethylpiperazine-N-ethanesulfonate (HEPES) in intracytoplasmic sperm injection procedures is detrimental to the outcome of in vitro fertilization. |
19,426,506 | Are c-Reactive protein gene variants associated with postoperative C-reactive protein levels after coronary artery bypass surgery? | {
"contexts": [
"Elevated baseline C-reactive protein (CRP) levels are associated with increased risk for developing cardiovascular disease. Several CRP gene variants have been associated with altered baseline CRP levels in ambulatory populations. However, the influence of CRP gene variants on CRP levels during i... | We identified a CRP gene SNP associated with lower postoperative CRP levels in patients undergoing CABG surgery with CPB. Further investigation is needed to clarify the significance of this association between CRP gene variants and the acute-phase rise in postoperative CRP levels with regard to the risk of adverse postoperative outcomes. | yes | C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. |
12,757,044 | Is systematic restaining of sputum smears for quality control useful in Burundi? | {
"contexts": [
"Routine tuberculosis control services in Burundi.",
"To determine whether systematic restaining of sputum smears for acid-fast bacilli (AFB) prior to rechecking quality assessment is necessary.",
"Blinded rechecking of peripheral routine smears, including a second control of discordants, ... | Despite mild climatic conditions in Burundi, restaining all slides before rechecking revealed an unrecognised, widespread problem of false negatives, rather than false positives. This indicated the need for critical re-appraisal of the standard procedure using cold staining, rather than re-training, as would have been inferred from results without restaining. Systematic restaining of all slides prior to rechecking may be more widely needed in National Tuberculosis Programmes to cover all possible serious causes of error. Cold staining should be avoided in field programmes since its performance is easily affected by frequently encountered adverse factors. | yes | Systematic restaining of sputum smears for quality control is useful in Burundi. |
22,187,313 | Does intratumoral heterogeneity of F-18 FDG uptake differentiate between gastrointestinal stromal tumors and abdominal malignant lymphomas on PET/CT? | {
"contexts": [
"Gastrointestinal stromal tumors (GISTs) and malignant lymphomas (MLs) in the abdomen are often observed as tumors of unknown origin on F-18 FDG PET/CT. The purpose of this study was to evaluate the intratumoral metabolic heterogeneity of F-18 FDG uptake on PET to determine if it might be helpful ... | GISTs exhibited significantly heterogeneous intratumoral tracer uptake as compared with the MLs. Evaluation of the intratumoral heterogeneity of F-18 FDG uptake may help in the discrimination between these tumors. | yes | Intratumoral heterogeneity of F-18 FDG uptake differentiates between gastrointestinal stromal tumors and abdominal malignant lymphomas on PET/CT. |
20,869,695 | Does supplementation of green tea catechins in dentifrices suppress gingival oxidative stress and periodontal inflammation? | {
"contexts": [
"this study examined the effects of a dentifrice containing green tea catechins on gingival oxidative stress and periodontal inflammation using a rat model.",
"twenty-four male Wister rats were randomly divided into four groups. The first group (Control group) received no treatment for 8 weeks... | adding green tea catechins to a dentifrice may contribute to prevention of periodontal inflammation by decreasing gingival oxidative stress and expression of pro-inflammatory cytokines. | yes | Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. |
23,924,189 | Does body mass index affect proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells? | {
"contexts": [
"Obesity is associated with a higher risk of developing cancer and co-morbidities that are part of the metabolic syndrome. Adipose tissue is recognized as an endocrine organ, as it affects a number of physiological functions, and contains adipose tissue-derived stem cells (ASCs). ASCs can differen... | These data demonstrate that elevated BMI resulted in reduced ASC proliferation, and potentially compromised osteogenic capacity in vitro; thus BMI is an important criterion to consider in selecting ASC donors for clinical applications. | yes | Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells. |
19,301,586 | Is expression of toll-like receptor 2 mRNA in bronchial epithelial cells induced in RAO-affected horses? | {
"contexts": [
"Airway inflammation in recurrent airway obstruction (RAO) is triggered by housing affected horses in stables.It has been suggested that RAO is an allergic condition, but innate immune mechanisms are also involved. Fungal products activate innate immune mechanisms through toll-like receptor 2 (TLR... | Stabling does not lead to an increase in TLR2 expression. Other molecules or processes in the TLR2 cascade might be important in fungal-induced airway inflammation. Equine epithelial-derived A20 may be involved in modulation of airway inflammation. | no | Expression of toll-like receptor 2 mRNA in bronchial epithelial cells is induced in RAO-affected horses. |
15,505,458 | Does introduction of anesthesia resident trainees to the operating room lead to changes in anesthesia-controlled times for efficiency measures? | {
"contexts": [
"Operating room efficiency is an important concern in most hospitals today. Little work has been reported to evaluate the contribution of anesthesia residents to changes in anesthesia-controlled time-related efficiencies in the operating room. The goal of this study was to measure the impact of th... | Although statistically significant time differences were found, these data strongly suggest that the initiation of anesthesia trainees to the operating room has no clinically or economically meaningful adverse effect on the anesthesia-controlled time component of operating room efficiency. | no | Introduction of anesthesia resident trainees to the operating room leads to changes in anesthesia-controlled times for efficiency measures. |
20,336,321 | Is the `` inside approach of the gallbladder '' an alternative to the classic Calot 's triangle dissection for a safe operation in severe cholecystitis? | {
"contexts": [
"External dissection of Calot's triangle and the gallbladder associated with complete cholecystectomy is considered the gold standard technique to achieve a safe cholecystectomy. However, in severe acute or chronic cholecystitis, the laparoscopic application of this standard technique may be techn... | An endovesicular approach for gallbladder dissection followed by subtotal cholecystectomy is a safe alternative to the classic Calot's dissection in the case of severe cholecystitis or difficult local conditions. This technique is recommended as an attractive solution to prevent bile duct injury, particularly when severe inflammation is associated to extrahepatic anatomic variants of the biliary tree. | yes | The `` inside approach of the gallbladder '' is an alternative to the classic Calot 's triangle dissection for a safe operation in severe cholecystitis. |
23,225,311 | Does bcl-2 enhance the formation of newborn striatal long-projection neurons in adult rat brain after a transient ischemic stroke? | {
"contexts": [
"It has been reported that B-cell lymphoma 2 (Bcl-2) enhances neurogenesis as well as supporting axonal growth after injury. In the present study, we investigated whether Bcl-2 overexpression plays a role in the formation of newborn striatonigral projection neurons in the adult rat brain after tra... | Taken together, we found that Bcl-2 overexpression in the brain enhanced the generation of newborn striatonigral projection neurons. This provides a potential strategy for promoting the reestablishment of neural networks and brain repair after ischemic injury. | yes | Bcl-2 enhances the formation of newborn striatal long-projection neurons in adult rat brain after a transient ischemic stroke. |
23,104,652 | Does bioinformatics analysis reveal potential candidate drugs for psychological stress in ovarian cancer? | {
"contexts": [
"Women with ovarian cancer may be at increased risk for psychological distress around the time of diagnosis relative to patients diagnosed with other cancers, because of the seriousness of the disease. However, the molecular mechanism of this effect is far from clear.",
"We sought to investiga... | Our findings may be useful for the development of management strategies for psychological distress, and we suggest that there is a need for improvement in the quality of life of cancer outpatients being treated with chemotherapy. | yes | Bioinformatics analysis reveals potential candidate drugs for psychological stress in ovarian cancer. |
25,266,244 | Is autonomic dysfunction associated with brief episodes of atrial fibrillation in type 2 diabetes? | {
"contexts": [
"This study aimed to investigate the relationship between asymptomatic episodes of atrial fibrillation (AF) and abnormalities of the autonomic nervous system in type 2 diabetic patients who did not have evidence of atrial fibrillation at baseline.",
"In a multicentric cross-sectional controlle... | This study originally showed a strong relationship between autonomic dysfunction and silent atrial fibrillation in type 2 diabetes. | yes | Autonomic dysfunction is associated with brief episodes of atrial fibrillation in type 2 diabetes. |
24,187,494 | Do muscular strength measurements indicate bone mineral density loss in postmenopausal women? | {
"contexts": [
"The literature is inconsistent and inconclusive on the relationship between bone mineral density (BMD) and muscular strength in postmenopausal women.",
"To evaluate the relationship between isokinetically and isometrically determined muscle strength and BMD in postmenopausal women of differen... | Different optimal strength measurements were identified for different age groups. Age-appropriate testing mode can improve detection of osteoporotic fracture risk in early menopause by determining muscular strength reduction related to BMD loss. This may enable early initiation of preventative therapies. | yes | Muscular strength measurements indicate bone mineral density loss in postmenopausal women. |
22,357,643 | Is history of sexual assault associated with greater declines in executive functioning in older adults with APOE epsilon4? | {
"contexts": [
"This study examined the longitudinal association between a prior history of sexual assault (SA), typically in youth, and decreasing executive functioning (EF) in old age and whether the apolipoprotein (APOE) ε4 allele modifies this relationship.",
"In this longitudinal study, 846 community-dw... | SA exposure earlier in life may increase risk for declines in EF 50-60 years later in old age, particularly in the context of the APOE ε4 allele. These results generally support a diathesis-stress model of decreased cognitive reserve. | yes | History of sexual assault is associated with greater declines in executive functioning in older adults with APOE epsilon4. |
End of preview. Expand
in Data Studio
README.md exists but content is empty.
- Downloads last month
- 108