id stringlengths 17 50 | question null | answer stringlengths 22 6.88k |
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nfcorpus-corpus-MED-2427 | null | Elevated Levels of Cholesterol-Rich Lipid Rafts in Cancer Cells Are Correlated with Apoptosis Sensitivity Induced by Cholesterol-Depleting Agents
Lipid rafts/caveolae are membrane platforms for signaling molecules that regulate various cellular functions, including cell survival. To better understand the role of rafts ... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-10 | null | Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland
Recent studies have suggested that statins, an established drug group in the prevention of cardiovascular mortality, could delay or prevent breast cancer recurrence but the effect on disease-specific mortality remains unclear. We evaluated ri... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2429 | null | Statin use and risk of breast cancer: a meta-analysis of observational studies.
Emerging evidence suggests that statins' may decrease the risk of cancers. However, available evidence on breast cancer is conflicting. We, therefore, examined the association between statin use and risk of breast cancer by conducting a det... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2430 | null | beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism.
The objective of this study was to investigate the effects of the dietary phytosterol beta-sitosterol (SIT) and the antiestrogen drug tamoxifen (TAM) on cell growth and ceramide (CER) metabolism in MCF-7 and MDA-MB... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2431 | null | Long-term statin use and risk of ductal and lobular breast cancer among women 55-74 years of age
Background Mechanistic studies largely support the chemopreventive potential of statins. However, results of epidemiologic studies investigating statin use and breast cancer risk have been inconsistent and lacked the abilit... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-14 | null | Statin use after diagnosis of breast cancer and survival: a population-based cohort study.
BACKGROUND: Preclinical studies have shown that statins, particularly simvastatin, can prevent growth in breast cancer cell lines and animal models. We investigated whether statins used after breast cancer diagnosis reduced the r... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2432 | null | The Garden of Eden--plant based diets, the genetic drive to conserve cholesterol and its implications for heart disease in the 21st century.
It is likely that plant food consumption throughout much of human evolution shaped the dietary requirements of contemporary humans. Diets would have been high in dietary fiber, ve... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2428 | null | Women and statin use: a women's health advocacy perspective.
This paper is based on a longer report on the benefits, safety and modalities of information representation with regard to women and statin use, situated within the historical context of Women's Health Movement which has advocated for unbiased, appropriate me... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2440 | null | Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea
Purpose To further clarify the relationship between total cholesterol and cancer, which remains unclear. Methods We prospectively examined the association between total cholesterol and site-specific and all-cancer incidence among 1,189,719 Korean a... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2434 | null | High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation.
The specific role of dietary fat in breast cancer progression is unclear, although a low-fat diet was associated with decreased recurrence of estrogen receptor alpha negative (ER(-)) breast c... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2435 | null | Chemoprevention of breast cancer by dietary compounds.
Breast cancer is the leading cause of cancer-related deaths in women in the United States and many other countries. There is an immediate need for more effective and less toxic therapeutic and preventive strategies for many cancers, especially for breast cancer. Na... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2436 | null | Content of low density lipoprotein receptors in breast cancer tissue related to survival of patients.
The content of low density lipoprotein (LDL) receptors in tissue from primary breast cancers was determined and its prognostic information compared with that of variables of established prognostic importance. Frozen tu... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2437 | null | Diet and breast cancer: understanding risks and benefits.
BACKGROUND: Breast cancer is the most commonly diagnosed cancer among women in the United States. Extensive research has been completed to evaluate the relationship between dietary factors and breast cancer risk and survival after breast cancer; however, a summa... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2438 | null | The association between dietary lignans, phytoestrogen-rich foods, and fiber intake and postmenopausal breast cancer risk: a German case-control st...
Phytoestrogens are structurally similar to estrogens and may affect breast cancer risk by mimicking estrogenic/antiestrogenic properties. In Western societies, whole gra... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2439 | null | Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer
While many factors are involved in the etiology of cancer, it has been clearly established that diet significantly impacts one’s risk for this disease. More recently, specific food components have been identified which are uniquely benefici... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-3597 | null | Trans Fat Consumption and Aggression
Background Dietary trans fatty acids (dTFA) are primarily synthetic compounds that have been introduced only recently; little is known about their behavioral effects. dTFA inhibit production of omega-3 fatty acids, which experimentally have been shown to reduce aggression. Potential... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-3598 | null | A prospective study of intake of trans-fatty acids from ruminant fat, partially hydrogenated vegetable oils, and marine oils and mortality from CVD.
Trans-fatty acids (TFA) have adverse effects on blood lipids, but whether TFA from different sources are associated with risk of CVD remains unresolved. The objective of t... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-3599 | null | Updated estimate of trans fat intake by the US population.
The dietary intake of industrially-produced trans fatty acids (IP-TFA) was estimated for the US population (aged 2 years or more), children (aged 2-5 years) and teenage boys (aged 13-18 years) using the 2003-2006 National Health and Nutrition Examination Survey... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-4556 | null | Tolerable upper intake levels for trans fat, saturated fat, and cholesterol.
Tolerable upper intake levels (ULs) set by the Institute of Medicine (IOM) are important, in part because they are used for estimating the percentage of the population at potential risk of adverse effects from excessive nutrient intake. The IO... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-4559 | null | Can a statin neutralize the cardiovascular risk of unhealthy dietary choices?
The cardiovascular risk reduction associated with different statins for the prevention of cardiovascular disease and the cardiovascular risk increase associated with excess dietary intake of fat have been quantified. However, these relative r... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-4560 | null | Preventing and arresting coronary atherosclerosis.
The good news about coronary atherosclerosis is that it takes an awful lot of plaque before symptoms of myocardial ischemia occur. The bad news is that despite the need for large quantities of plaque for symptoms to occur, nevertheless nearly half of us in the United S... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-4828 | null | Association between statin-associated myopathy and skeletal muscle damage
Background Many patients taking statins often complain of muscle pain and weakness. The extent to which muscle pain reflects muscle injury is unknown. Methods We obtained biopsy samples from the vastus lateralis muscle of 83 patients. Of the 44 p... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-4829 | null | Statin therapy, muscle function and falls risk in community-dwelling older adults.
BACKGROUND: Statin therapy can cause myopathy, however it is unclear whether this exacerbates age-related muscle function declines. AIM: To describe differences between statin users and non-users in muscle mass, muscle function and falls... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-4830 | null | Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia.
Muscle pain and weakness are frequent complaints in patients receiving 3-hydroxymethylglutaryl coenzymeA (HMG CoA) reductase inhibitors (statins). Many patients with myalgia have creatine kinase levels that are either normal o... |
nfcorpus-queries-PLAIN-2 | null | Do Cholesterol Statin Drugs Cause Breast Cancer? |
nfcorpus-corpus-MED-2513 | null | Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life
Over the last several years, new evidence has kept pouring in about the remarkable effect of caloric restriction (CR) on the conspicuous bedfellows- aging and cancer. Through the use of various animal models, it is now ... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5237 | null | mTOR: from growth signal integration to cancer, diabetes and ageing
Preface In all eukaryotes, the target of rapamycin (TOR) signaling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stre... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-2517 | null | mTOR is a key modulator of ageing and age-related disease
Many experts in the biology of ageing believe that pharmacological interventions to slow ageing are a matter of ‘when’ rather than ‘if’. A leading target for such interventions is the nutrient response pathway defined by the mechanistic target of rapamycin (mTOR... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-2518 | null | Aging is not programmed
Aging is not and cannot be programmed. Instead, aging is a continuation of developmental growth, driven by genetic pathways such as mTOR. Ironically, this is often misunderstood as a sort of programmed aging. In contrast, aging is a purposeless quasi-program or, figuratively, a shadow of actual ... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-2519 | null | Caloric restriction in humans: potential pitfalls and health concerns.
To date, the only intervention that has consistently been shown to slow the rate of aging, and to increase mean and maximum lifespan in short-lived species, is life-long calorie restriction. It is yet unclear whether long-term calorie restriction in... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-2520 | null | TOR-driven aging: speeding car without brakes.
This article discusses that the traditional analogy of an aging organism with a rusting (albeit self-repairing) car is misleading. The true analogy is a speeding car that enters a low-speed zone and damages itself because it does not and cannot slow down. For such a car wi... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-2521 | null | Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.
A streptomycete was isolated from an Easter Island soil sample and found to inhibit Candida albicans, Microsporum gypseum and Trichophyton granulosum. The antibiotic-producing microorgan... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-2514 | null | Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis
Healthy life span is rapidly increasing and human aging seems to be postponed. As recently exclaimed in Nature, these findings are so perplexing that they can be dubbed the 'longevity riddle'. To explain current i... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-2943 | null | Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk.
BACKGROUND: Western diets, which typically contain large amounts of energy-dense processed foods, together with a sedentary lifestyle are associated with increased cardiometabolic risk. We evaluated the lon... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5322 | null | Characterization of bacteria, clostridia and Bacteroides in faeces of vegetarians using qPCR and PCR-DGGE fingerprinting.
BACKGROUND/AIMS: This study aimed to investigate the quantitative and qualitative changes of bacteria, Bacteroides, Bifidobacterium and Clostridium cluster IV in faecal microbiota associated with a ... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5323 | null | Endocrine-disrupting chemicals and obesity development in humans: a review.
This study reviewed the literature on the relations between exposure to chemicals with endocrine-disrupting abilities and obesity in humans. The studies generally indicated that exposure to some of the endocrine-disrupting chemicals was associa... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5324 | null | Effects of a high-fat meal on pulmonary function in healthy subjects.
Obesity has important health consequences, including elevating risk for heart disease, diabetes, and cancer. A high-fat diet is known to contribute to obesity. Little is known regarding the effect of a high-fat diet on pulmonary function, despite the... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5325 | null | Vegetarian diets and blood pressure among white subjects: results from the Adventist Health Study-2 (AHS-2)
Objective Previous work studying vegetarians has often found that they have lower blood pressure (BP). Reasons may include their lower BMI and higher intake levels of fruit and vegetables. Here we seek to extend ... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5326 | null | Red meat and colon cancer: should we become vegetarians, or can we make meat safer?
The effect of meat consumption on cancer risk is a controversial issue. However, recent meta-analyses show that high consumers of cured meats and red meat are at increased risk of colorectal cancer. This increase is significant but mode... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5327 | null | The association between dietary patterns and mental health in early adolescence.
OBJECTIVE: To investigate the associations between dietary patterns and mental health in early adolescence. METHOD: The Western Australian Pregnancy Cohort (Raine) Study is a prospective study of 2900 pregnancies recruited from 1989-1992. ... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5328 | null | Vegetarian diets and incidence of diabetes in the Adventist Health Study-2
Aim To evaluate the relationship of diet to incident diabetes among non-Black and Black participants in the Adventist Health Study-2. Methods and Results Participants were 15,200 men and 26,187 women (17.3% Blacks) across the U.S. and Canada who... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5329 | null | Rapid reduction of serum cholesterol and blood pressure by a twelve-day, very low fat, strictly vegetarian diet.
OBJECTIVE: This study was conducted to demonstrate the effectiveness of a strictly vegetarian, very low-fat diet on cardiac risk factor modification. METHODS: Five hundred men and women, participants in an i... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5330 | null | Effect of a single high-fat meal on endothelial function in healthy subjects.
Although there is a well-established relation between serum cholesterol and coronary artery disease risk, individual and national variations in this association suggest that other factors are involved in atherogenesis. High-fat diet associate... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5331 | null | Influencing public nutrition for non-communicable disease prevention: from community intervention to national programme--experiences from Finland.
A global health transition is currently underway. The burden of non-communicable diseases (NCDs) is increasing rapidly in the developing world, very much as a result of chan... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5332 | null | Quantification of butyryl CoA:acetate CoA-transferase genes reveals different butyrate production capacity in individuals according to diet and age.
The gastrointestinal microbiota produces short-chain fatty acids, especially butyrate, which affect colonic health, immune function and epigenetic regulation. To assess th... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5333 | null | Vegetarian diet affects genes of oxidative metabolism and collagen synthesis.
BACKGROUND/AIM: A vegetarian diet is known to prevent a series of diseases but may influence the balance of carbohydrate and fat metabolism as well as collagen synthesis. This study compares expression patterns of relevant genes in oral mucos... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5334 | null | Protein-source tryptophan as an efficacious treatment for social anxiety disorder: a pilot study.
Until recently, intact protein that is rich in tryptophan was not seen as an alternative to pharmaceutical-grade tryptophan because protein also contains large neutral amino acids (LNAAs) that compete for transport sites a... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5335 | null | Does a vegan diet reduce risk for Parkinson's disease?
Three recent case-control studies conclude that diets high in animal fat or cholesterol are associated with a substantial increase in risk for Parkinson's disease (PD); in contrast, fat of plant origin does not appear to increase risk. Whereas reported age-adjusted... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5363 | null | Dietary patterns and depressive symptoms among Japanese men and women.
OBJECTIVE: Although several studies have reported associations of depressive state with specific nutrients and foods, few studies examined the association with dietary patterns in adults. We investigated the association between major dietary pattern... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5337 | null | Intensive lifestyle changes may affect the progression of prostate cancer.
PURPOSE: Men with prostate cancer are often advised to make changes in diet and lifestyle, although the impact of these changes has not been well documented. Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate spec... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
nfcorpus-corpus-MED-5338 | null | Original Articles: Vegetarian Compared with Meat Dietary Protein Source and Phosphorus Homeostasis in Chronic Kidney Disease
Summary Background and objectives Patients with advanced chronic kidney disease (CKD) are in positive phosphorus balance, but phosphorus levels are maintained in the normal range through phosphat... |
nfcorpus-queries-PLAIN-12 | null | Exploiting Autophagy to Live Longer |
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