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Which molecule is targeted by a monoclonal antibody Mepolizumab? | <answer> interleukin-5 <context> Mepolizumab: 240563, anti-IL-5 monoclonal antibody - GlaxoSmithKline, anti-interleukin-5 monoclonal antibody - GlaxoSmithKline, SB 240563. Mepolizumab is an anti-interleukin-5 monoclonal antibody that is in clinical trials with GlaxoSmithKline (GSK) for the treatment of severe asthma, n... |
Which molecule is targeted by a monoclonal antibody Mepolizumab? | <answer> interleukin-5 <context> Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibody. Mepolizumab is a fully humanized monoclonal antibody (IgG1/κ) targeting human interleukin-5 (IL-5), a key haematopoietin needed for eosinophil development and function. Mepolizumab blocks hu... |
Which molecule is targeted by a monoclonal antibody Mepolizumab? | <answer> interleukin-5 <context> Mepolizumab: 240563, anti-IL-5 monoclonal antibody - GlaxoSmithKline, anti-interleukin-5 monoclonal antibody - GlaxoSmithKline, SB 240563. Mepolizumab is an anti-interleukin-5 monoclonal antibody that is in clinical trials with GlaxoSmithKline (GSK) for the treatment of severe asthma, n... |
Which molecule is targeted by a monoclonal antibody Mepolizumab? | <answer> interleukin-5 <context> Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibody. Mepolizumab is a fully humanized monoclonal antibody (IgG1/κ) targeting human interleukin-5 (IL-5), a key haematopoietin needed for eosinophil development and function. Mepolizumab blocks hu... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> A structural mechanism for calcium transporter headpiece closure. To characterize the conformational dynamics of sarcoplasmic reticulum (SR) calcium pump (SERCA) we performed molecular dynamics simulations beginning with several different high-resolution structures. We quantified differences in... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA. Adipose tissue is central to the regulation of lipid metabolism. Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), one of the most severe lipodystrophy diseases, is caused by mutation of the Seipin gene. Seipi... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA. Adipose tissue is central to the regulation of lipid metabolism. Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), one of the most severe lipodystrophy diseases, is caused by mutation of the Seipin gene. Seipi... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> Sarcoplasmic reticulum Ca(2+)-ATPase <context> Modulation of rabbit muscle sarcoplasmic reticulum Ca(2+)-ATPase activity by novel quercetin derivatives. Sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) is the pump crucial for calcium homeostasis and its impairment results in pathologies such as myopathy, heart fai... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> Modulation of rabbit muscle sarcoplasmic reticulum Ca(2+)-ATPase activity by novel quercetin derivatives. Sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) is the pump crucial for calcium homeostasis and its impairment results in pathologies such as myopathy, heart failure or diabetes. Modulation of... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA2 <context> Targeting sarcoplasmic reticulum calcium ATPase by gene therapy. Although pharmacologic therapies have provided gains in reducing the mortality of heart failure, the rising incidence of the disease requires new approaches to combat its health burden. Twenty-five years ago, abnormal calcium cyc... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA2 <context> Immunosuppression decreases inflammation and increases AAV6-hSERCA2a-mediated SERCA2a expression. The calcium pump SERCA2a (sarcoplasmic reticulum calcium ATPase 2a), which plays a central role in cardiac contraction, shows decreased expression in heart failure (HF). Increasing SERCA2a express... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> Endoplasmic reticulum calcium pumps and cancer. Endoplasmic reticulum calcium homeostasis is involved in a multitude of signaling, as well as "house-keeping" functions that control cell growth, differentiation or apoptosis in every human/eukaryotic cell. Calcium is actively accumulated in the e... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tran... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA2 <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tra... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA2 <context> SERCA in genesis of arrhythmias: what we already know and what is new? This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias. SERCA is a membrane protein that belongs to the family of P-type ion tra... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> g mec <context> Calcium binding and allosteric signaling mechanisms for the sarcoplasmic reticulum Ca²+ ATPase. The sarcoplasmic reticulum Ca²⁺ ATPase (SERCA) is a membrane-bound pump that utilizes ATP to drive calcium ions from the myocyte cytosol against the higher calcium concentration in the sarcoplasmic r... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> Sarcoplasmic reticulum Ca(2+)-ATPase <context> Modulation of rabbit muscle sarcoplasmic reticulum Ca(2+)-ATPase activity by novel quercetin derivatives. Sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) is the pump crucial for calcium homeostasis and its impairment results in pathologies such as myopathy, heart fai... |
Which is the main calcium pump of the sarcoplasmic reticulum? | <answer> SERCA <context> Modulation of rabbit muscle sarcoplasmic reticulum Ca(2+)-ATPase activity by novel quercetin derivatives. Sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) is the pump crucial for calcium homeostasis and its impairment results in pathologies such as myopathy, heart failure or diabetes. Modulation of... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Woman with x-linked recessive dystonia-parkinsonism: clue to the epidemiology of parkinsonism in Filipino women? IMPORTANCE: Despite recessive inheritance, X-linked dystonia-parkinsonism (Lubag disease) has also been described in women presenting with a late-onset isola... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> x-linked dystonia-parkinsonism <context> Rare causes of dystonia parkinsonism. The list of genetic causes of syndromes of dystonia parkinsonism grows constantly. As a consequence, the diagnosis becomes more and more challenging for the clinician. Here, we summarize the important causes of dystonia parkinsonism... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Neuropsychological profile of a Filipino gentleman with X-linked dystonia-parkinsonism: a case report of Lubag disease. X-Linked Dystonia-Parkinsonism (XDP or "Lubag") is a progressive neurodegenerative disorder unique to the Island of Panay in the Philippines. Imaging ... |
What is the synonym of the lubag disease? | <answer> X-Linked Dystonia-Parkinsonism <context> Neuropsychological profile of a Filipino gentleman with X-linked dystonia-parkinsonism: a case report of Lubag disease. X-Linked Dystonia-Parkinsonism (XDP or "Lubag") is a progressive neurodegenerative disorder unique to the Island of Panay in the Philippines. Imaging ... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> First case of X-linked dystonia-parkinsonism ("Lubag") to demonstrate a response to bilateral pallidal stimulation. "Lubag" or X-linked dystonia-parkinsonism (XDP) is a genetic syndrome afflicting Filipino men. Intracranial surgical procedures for Lubag have been unsucc... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> First case of X-linked dystonia-parkinsonism ("Lubag") to demonstrate a response to bilateral pallidal stimulation. "Lubag" or X-linked dystonia-parkinsonism (XDP) is a genetic syndrome afflicting Filipino men. Intracranial surgical procedures for Lubag have been unsucc... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Phenotypic and molecular analyses of X-linked dystonia-parkinsonism ("lubag") in women. BACKGROUND: X-linked dystonia-parkinsonism (XDP) or "lubag" is an X-linked recessive disorder that afflicts Filipino men, and rarely, women. Genetic confirmation is performed through... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Phenotypic and molecular analyses of X-linked dystonia-parkinsonism ("lubag") in women. BACKGROUND: X-linked dystonia-parkinsonism (XDP) or "lubag" is an X-linked recessive disorder that afflicts Filipino men, and rarely, women. Genetic confirmation is performed through... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study. We administered a culturally corrected University of Pennsylvania Smell Identification Test (ccUPSIT) consisting of 25 odor items to 20 patients with 'Lubag' or X-linked dystonia-park... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study. We administered a culturally corrected University of Pennsylvania Smell Identification Test (ccUPSIT) consisting of 25 odor items to 20 patients with 'Lubag' or X-linked dystonia-park... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> A novel family with an unusual early-onset generalized dystonia. We report on an Italian family in which three brothers and their maternal grandfather had a generalized early-onset dystonia with mild parkinsonian signs. Genetic testing excluded the rapid-onset dystonia-... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Phenomenology of "Lubag" or X-linked dystonia-parkinsonism. X-linked dystonia-parkinsonism (XDP), or Lubag syndrome, is known to cause progressive dystonia, with or without parkinsonism, among Filipino male adults with maternal roots from the Philippine island of Panay.... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Phenomenology of "Lubag" or X-linked dystonia-parkinsonism. X-linked dystonia-parkinsonism (XDP), or Lubag syndrome, is known to cause progressive dystonia, with or without parkinsonism, among Filipino male adults with maternal roots from the Philippine island of Panay.... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-Parkinsonism <context> Adductor laryngeal breathing dystonia in a patient with lubag (X-linked dystonia-Parkinsonism syndrome). We report a patient with Lubag (X-linked dystonia-parkinsonism) who presented with severe respiratory stridor from adductor laryngeal breathing dystonia. Emergency t... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Adductor laryngeal breathing dystonia in a patient with lubag (X-linked dystonia-Parkinsonism syndrome). We report a patient with Lubag (X-linked dystonia-parkinsonism) who presented with severe respiratory stridor from adductor laryngeal breathing dystonia. Emergency t... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Phenotypic expression of X-linked dystonia-parkinsonism (lubag) in two women. Lubag (X-linked dystonia-parkinsonism) has been considered a sex-linked recessive trait and has been mapped to the pericentromeric region of the X chromosome. We studied a 54-year-old man with... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Phenotypic expression of X-linked dystonia-parkinsonism (lubag) in two women. Lubag (X-linked dystonia-parkinsonism) has been considered a sex-linked recessive trait and has been mapped to the pericentromeric region of the X chromosome. We studied a 54-year-old man with... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Positron emission tomographic findings in Filipino X-linked dystonia-parkinsonism. Regional and global metabolic rates for glucose (rCMRGlc and GMR) were estimated using [18F]fluorodeoxyglucose and positron emission tomography in 3 patients with Filipino X-linked dyston... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Genetic mapping of "Lubag" (X-linked dystonia-parkinsonism) in a Filipino kindred to the pericentromeric region of the X chromosome. "Lubag" is an X-linked disorder causing dystonia and parkinsonism that has only been described in families from the Philippines, principa... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Neuropsychological profile of a Filipino gentleman with X-linked dystonia-parkinsonism: a case report of Lubag disease. X-Linked Dystonia-Parkinsonism (XDP or "Lubag") is a progressive neurodegenerative disorder unique to the Island of Panay in the Philippines. Imaging ... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Woman with x-linked recessive dystonia-parkinsonism: clue to the epidemiology of parkinsonism in Filipino women? IMPORTANCE: Despite recessive inheritance, X-linked dystonia-parkinsonism (Lubag disease) has also been described in women presenting with a late-onset isola... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-Linked Dystonia-Parkinsonism <context> Neuropsychological profile of a Filipino gentleman with X-linked dystonia-parkinsonism: a case report of Lubag disease. X-Linked Dystonia-Parkinsonism (XDP or "Lubag") is a progressive neurodegenerative disorder unique to the Island of Panay in the Philippines. Imaging ... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Neuropsychological profile of a Filipino gentleman with X-linked dystonia-parkinsonism: a case report of Lubag disease. X-Linked Dystonia-Parkinsonism (XDP or "Lubag") is a progressive neurodegenerative disorder unique to the Island of Panay in the Philippines. Imaging ... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Neuropsychological profile of a Filipino gentleman with X-linked dystonia-parkinsonism: a case report of Lubag disease. X-Linked Dystonia-Parkinsonism (XDP or "Lubag") is a progressive neurodegenerative disorder unique to the Island of Panay in the Philippines. Imaging ... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Neuropsychological profile of a Filipino gentleman with X-linked dystonia-parkinsonism: a case report of Lubag disease. X-Linked Dystonia-Parkinsonism (XDP or "Lubag") is a progressive neurodegenerative disorder unique to the Island of Panay in the Philippines. Imaging ... |
What is the synonym of the lubag disease? | <answer> X-linked dystonia-parkinsonism <context> Anesthesia for deep brain stimulation in a patient with X-linked dystonia-parkinsonism/Lubag disease. Lubag disease is a genetic X-linked dystonia-parkinsonism syndrome afflicting Filipino men. This disease is characterized by dystonia dominating the first 10-15 years o... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and AID have similar nuclear import mechanisms. Members of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family catalyze DNA cytosine deamination and underpin a variety of immune defenses. For instance, several family members, including APOBEC... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and AID have similar nuclear import mechanisms. Members of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family catalyze DNA cytosine deamination and underpin a variety of immune defenses. For instance, several family members, including APOBEC... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and AID have similar nuclear import mechanisms. Members of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family catalyze DNA cytosine deamination and underpin a variety of immune defenses. For instance, several family members, including APOBEC... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and AID have similar nuclear import mechanisms. Members of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family catalyze DNA cytosine deamination and underpin a variety of immune defenses. For instance, several family members, including APOBEC... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> The role of amino-terminal sequences in cellular localization and antiviral activity of APOBEC3B. Human APOBEC3B (A3B) has been described as a potent inhibitor of retroviral infection and retrotransposition. However, we found that the predominantly nuclear A3B only weakly restricted infectio... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> The role of amino-terminal sequences in cellular localization and antiviral activity of APOBEC3B. Human APOBEC3B (A3B) has been described as a potent inhibitor of retroviral infection and retrotransposition. However, we found that the predominantly nuclear A3B only weakly restricted infectio... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination. Humans have seven APOBEC3 DNA cytosine deaminases. The activity of these enzymes allows them to restrict a variety of retroviruses and retrotransposons, but may also cause pro-mutage... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. APOBEC3G limits the replication of human immunodeficiency virus type 1, other retroviruses, and retrotransposons. It localizes predominantly to the cytoplasm of cells, which is consistent ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome. The activity of L1 and related transposons such as Alu elements cause... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and AID have similar nuclear import mechanisms. Members of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family catalyze DNA cytosine deamination and underpin a variety of immune defenses. For instance, several family members, including APOBEC... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and AID have similar nuclear import mechanisms. Members of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family catalyze DNA cytosine deamination and underpin a variety of immune defenses. For instance, several family members, including APOBEC... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and AID have similar nuclear import mechanisms. Members of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) protein family catalyze DNA cytosine deamination and underpin a variety of immune defenses. For instance, several family members, including APOBEC... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B is an enzymatic source of mutation in breast cancer. Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome. The activity of L1 and related transposons such as Alu elements cause... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. APOBEC3G limits the replication of human immunodeficiency virus type 1, other retroviruses, and retrotransposons. It localizes predominantly to the cytoplasm of cells, which is consistent ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome. The activity of L1 and related transposons such as Alu elements cause... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B is an enzymatic source of mutation in breast cancer. Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. APOBEC3G limits the replication of human immunodeficiency virus type 1, other retroviruses, and retrotransposons. It localizes predominantly to the cytoplasm of cells, which is consistent ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome. The activity of L1 and related transposons such as Alu elements cause... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B is an enzymatic source of mutation in breast cancer. Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. APOBEC3G limits the replication of human immunodeficiency virus type 1, other retroviruses, and retrotransposons. It localizes predominantly to the cytoplasm of cells, which is consistent ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome. The activity of L1 and related transposons such as Alu elements cause... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B is an enzymatic source of mutation in breast cancer. Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination. Humans have seven APOBEC3 DNA cytosine deaminases. The activity of these enzymes allows them to restrict a variety of retroviruses and retrotransposons, but may also cause pro-mutage... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. APOBEC3G limits the replication of human immunodeficiency virus type 1, other retroviruses, and retrotransposons. It localizes predominantly to the cytoplasm of cells, which is consistent ... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome. The activity of L1 and related transposons such as Alu elements cause... |
Is APOBEC3B protein predominantly cytoplasmic or nuclear? | <answer> nuclear <context> APOBEC3B is an enzymatic source of mutation in breast cancer. Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at ... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Preclinical assessment of Orteronel(®), a CYP17A1 enzyme inhibitor in rats. Orteronel (TAK-700) is a novel and selective inhibitor of CYP17A1, which is expressed in testicular, adrenal and prostate tumor tissues. Orteronel is currently in Phase-III clinical development for metastatic castrati... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Preclinical assessment of Orteronel(®), a CYP17A1 enzyme inhibitor in rats. Orteronel (TAK-700) is a novel and selective inhibitor of CYP17A1, which is expressed in testicular, adrenal and prostate tumor tissues. Orteronel is currently in Phase-III clinical development for metastatic castrati... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Orteronel for the treatment of prostate cancer. Orteronel (also known as TAK-700) is a novel hormonal therapy that is currently in testing for the treatment of prostate cancer. Orteronel inhibits the 17,20 lyase activity of the enzyme CYP17A1, which is important for androgen synthesis in the ... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys. Orteronel (TAK-700) is an investigational, non-steroidal inhibitor of CYP17A1 wit... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys. Orteronel (TAK-700) is an investigational, non-steroidal inhibitor of CYP17A1 wit... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys. Orteronel (TAK-700) is an investigational, non-steroidal inhibitor of CYP17A1 wit... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Development and validation of an RP-HPLC method for the quantitation of Orteronel (TAK-700), a CYP17A1 enzyme inhibitor, in rat plasma and its application to a pharmacokinetic study. A novel, simple, specific, sensitive and reproducible high-performance liquid chromatography assay method has ... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. Surgical or pharmacologic methods to control gonadal androgen biosynthesis are effective approaches in the treatment... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. Surgical or pharmacologic methods to control gonadal androgen biosynthesis are effective approaches in the treatment... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. Surgical or pharmacologic methods to control gonadal androgen biosynthesis are effective approaches in the treatment... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. Surgical or pharmacologic methods to control gonadal androgen biosynthesis are effective approaches in the treatment... |
Which enzyme is inhibited by Orteronel? | <answer> CYP17A1 <context> Preclinical assessment of Orteronel(®), a CYP17A1 enzyme inhibitor in rats. Orteronel (TAK-700) is a novel and selective inhibitor of CYP17A1, which is expressed in testicular, adrenal and prostate tumor tissues. Orteronel is currently in Phase-III clinical development for metastatic castrati... |
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