UniProt ID stringlengths 6 10 | Protein Sequence stringlengths 2 35.2k | Functional Description stringlengths 5 30.7k |
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A4SGW2 | MDIKTLHPAIAAAYRVLETGEPISLEEAELLASLPGEFSLDLASLANKVRNRWGKGGIHACSIMNAKSGVCGENCRFCAQSRHNHADIEVYPLVDEDAVLFEARSCAEHGVSHFGLVTSGYGYRTMNAEFKRILAMIDRLHEELPELNVCASIGILGPETAAALARHGIAHYNINLQVAPEKYAGLIADTHGIEERMETVRLLRREGVNVCCGGIIGVGESMEDRVAMLFALRDLDVSVIPINVLVPIEGTPLQAAESVPLADIVKVFALARLVHPHSIIKFAAGRETLMKDFQGLLMLSGADGYLTGGYLTTRGRDLADDQRFSERLASFS | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q7DE82 | MREETVSWSLEDIREIYHTPVFELIHKANAILRSNFLHSELQTCYLISIKTGGCVEDCAYCAQSSRYHTHVTPEPMMKIVDVVERAKRAVELGATRVCLGAAWRNAKDDRYFDRVLAMVKSITDLGAEVCCALGMLSEEQAKKLYDAGLYAYNHNLDSSPEFYETIITTRSYEDRLNTLDVVNKSGISTCCGGIVGMGESEEDRIKLLHVLATRDHIPESVPVNLLWPIDGTPLQDQPPISFWEVLRTIATARVVFPRSMVRLAAGRAFLTVEQQTLCFLAGANSIFYGDKLLTVENNDIDEDAEMIKLLGLIPRPSFGIERGNPCYANNS | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q8KGB6 | MKSRLHPDIEKAYAVLDTGEPLSLELASALGRLPDSEVLDLVSLANRVKARHAANHGAIHACSIMNAKSGVCGENCRFCAQSKHNSAEVDVYELVDENKVLEQARSAWEQGIGHFGIVTSGYGYLKVTPEFERILGMIDRLHRELPGLHVCASLGVLGDAPAAELARHGIAHYNINIQVDPARYGELIADTHAVNERIGTIRRLRSNGIGVCCGGILGVGETMQERIGMIFALRDLDVTVIPLNVLVPIDGTPLEGAAPVSVPEIAKTFAICRLAHPTKIIKFAAGRETVMKDFQGLLMLAGADGFLTGGYLTTRGRDISTDRQLARQLSKFS | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q1QYD5 | MTAQSRDPAWTDASPTFQPTMRHDWSLEEIEALFALPFNDLLFRAQQVHRAHFDPNAVQVSTLLSIKTGACPEDCKYCPQSGHYNTGLGKEKLLEIEKVVEQARAAKAAGASRFCMGAAWRSPREKDLRVVTEMVGRVKALGLETCMTLGMVDVDQARRLAEAGLDYYNHNLDTSPDYYGEIITTRTYADRLETLANVREAGMKVCSGGILGMGEAPRDRAALLQQLVRLDPHPESVPINMLVKVPGTPMENVEDMDPLTFIRAIAVARILMPKSHVRLSAGREQMDESTQALAFLAGANSIFYGDTLLTTGNPQVERDRALFDKLGLHPEPSDPHADDAHRDDEQAEIALAHAIQRQRDDALFYDATRG | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q7NPW1 | MHSATMVFKRAATPHPEKAEWSVDDVEALLGLPFMELVFRAAEIHRQFFDPTKVQLSTLVSIKTGGCPEDCGYCPQSVHHDTPVADQPMMTVDEVVAAARQAKANGAGRFCMGAAWRGPKDADLQKTLDMVREVKALGLETCATFGLLRDGQAEQLKDAGLDYYNHNLDTAPDKYGDIIQTREYEDRLDTLGKVRKAGLSVCCGGIVGMNETRRDRAGLIVQLANLDPQPESVPVNNLVQVVGTPLEGAERLDWTEFVRTIAVARITMPASYVRLSAGRREMDEATQALCFLAGANSIFYGDKLLTTGNPDVVADQSLMAKLNLQPL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B5ECN1 | MEKMINDIAHRIIAGGSITEAEAIQLTQVQGTEVYDLFRAATRVKEHFVGNEVHLCSIINAKSGRCAENCAFCAQSAHHKTDAPVYPLVQEEEMLASARMAETNGSACFGIITSGTTVNGPELEQILTALRRIRKETTILPSCSLGIIDEETARKLKEAGMDTYHHNLETAASFFPQICTTHDYQDDVNTVRAVKKAGVKVCCGGIFGLGESAAQRVEMALTLKDLDVDSVPMNFLNPIEGTRLEGAANITAQECLKTIAIYRLILPGKRITVCGGREKNLRDLQSWIFFAGANGTMIGNYLTTLGRNVDTDLTMFSDLGLKTVMCAH | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
P12997 | MAHSS | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A8AJ12 | MAHHPRWTLSQVTELFNKPLLDLLFDAQQIHRQHFDPQQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLMEVEQVLDSARKAKNAGSTRFCMGAAWKNPHERDMPYLEQMVQGVKAMGLEACMTLGTLNESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRSYQERLDTLDKVREAGIKVCSGGIVGLGETVKDRAGLLLQLANLPTPPESVPINMLVKVKGTPLADNEDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPEEDKDLQLFRKLGLNPQQTSVLAGDNEQQQRLEQALMTPDTDDYYNAAAV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q97MI6 | MKNQWNNILSIGEKVLNGEKITADEALTLSKSNGSDIFLLCSFANKLREKFNGNHVDLCSVINAKSGNCSEDCAFCAQSAHHKANVSCYPLLNEDKILEMAKQREAYGARHCDIATSGLGYTGDEKDFQTILKAFKKMKENTNLKLCACLGTLTEKAMNSLAAVGVERYNHNLETAKSFYKNIVSTHGYDERIKTINYAKNAKMEVCSGMIVGLGETMEQRIEHALLLRDLNVDAVPVNILNPVKGTKLENAKPLSPMEIIKTFAIIRFILPDKIIRYAGGREKNLRSLQPLGFLSGLNGMLIGNYLTTNGQSVNDDFNMLKDLELEY | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A7FVS6 | MSNIIKYKKKILNGDLLTKEEVEELLEEDITDLAATANEIRESLCGNKFDLCTIINGKSGRCQENCKYCAQSAHFDTDIIEYNILNSDRIINSAISNYNKGVHRFSVVTSGRALNNNEVDTLCKTYSKLKETCSIRLCASHGLLKYEDLKRLKDSGVTRYHNNLETSRKFFTKICTTHKYDDKIETIKNAKKAGIEICSGGIIGLGETMEDRIDMAFTLRELSVESVPVNILNPIKGTPLENQEILSYEEIIKTLALFRFILPTVQIRLAGGRTIISDKGKKALESGVNGAISGDMLTTLGIETSEDIKMIKNLGFEV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A6LUQ4 | MEKLAEEIINGRRLTRSDDLEFLLTCDLKKICDGANKIRKTLCGESVDLCTIINGRSGKCSENCKFCAQSNHHKTEIKKYDFLDPNVILKDCKKNEANGVHRYSIVTAGRALVGSDFDKAVQAYKMMNKECSINLCASHGFLSEEQFVLLKEAGVTMYHANIETSKRNFHNICTTHSYDDKIKEIKLAQNAGLKVCSGGIIGMGETWYDRIDMAISLSELGVISIPINVLMPIKGTPLENLKRISNYDILRTIAIFRYINPTAYIRMAAGRTYFEDGGIEIFQSGSNATITGDMLTTVGNNTCQDKIMLQTLGFSI | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B2V167 | MNIIDRFKEKILSGELISKKEAIILSKENVDKLASAANDIRMSLCGKKFNLCTIINGKSGRCGENCKYCAQSVYFKTDIEEYNLLDSESIITSAISNYNSGVHRFSVVTSGKKLTNKEIDIVCKTYSEVQEKCAIKLCASHGLLNYEELVKLKESGVIRYHNNLETSRRFFSNICTTHTFDEKINTIKNALKAGLQVCSGGIIGLGETMEDRIDMAFTLRELNVDSIPINILNPIKGTALENQEKLSYDEITKTFALFRFILPEKQIRLAGGRALLNDKGERLMKSGVNSAISGDMLTTSGIKTFDDIKMIKELGFEV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B2TL73 | MNIVDKFKEKILSGELISKKEAMILSKENIDELASAANDIRMSLCGKEFNLCTIINGKSGRCGENCKYCAQSVYFKTDIEEYNLLDSESIITSAISNYNNGVHRFSVVTSGKKITNKEVHTVCKTYSELKDKCDIKLCASHGLLNYEELVKLKESGVIRYHNNLETSRNFFSNICTTHTFDEKTHTIKNALKAGLQVCSGGIIGLGETMEDRIDMAFTLRELNVDSIPINILNPIKGTALENQEKLSYDEITKTFALFRFILPKKQIRLAGGRALLNDKGERLMKSGVNAAISGDMLTTSGIKTFDDIKMIKELGFEV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A7G5G4 | MSNIIKYKKKILNGDLLTKEEVEELLEEDITDLAATANEIRESLCGNKFDLCTIINGKSGRCQENCKYCAQSAHFDTDIIEYNILNSDRIINSAISNYNKGVHRFSVVTSGRALNNNEVDTLCKTYSKLKETCSIRLCASHGLLKYEDLKRLKDSGVTRYHNNLETSRKFFTKICTTHKYDDKIETIKNAKKAGIEICSGGIIGLGETMEDRIDMAFTLRELSVESVPVNILNPIKGTPLENQEILSYEEIIKTLALFRFILPTVQIRLAGGRTIISDKGKKALESGVNGAISGDMLTTLGIETSEDIKMIKNLGFEV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B1IHH9 | MSNIIKYKKKILNGDLLTKEEVEELLEEDITDLAATANEIRESLCGNKFDLCTIINGKSGRCQENCKYCAQSAHFDTDIIEYNILNSDRIMNSAISNYNKGVHRFSVVTSGRALNNNEVDTLCKTYLKLKETCSIRLCASHGLLKYEDLKRLKDSGVTRYHNNLETSRKFFTKICTTHKYDDKIETIKNAKKAGFEICSGGIIGLGETMEDRIDMAFTLRELSVESVPVNILNPIKGTPLENQEILSYEEIIKTLALFRFILPTVQIRLAGGRTIISDKGKKALESGVNGAISGDMLTTLGIETSEDIKMIKNLGFEV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A7GFJ9 | MSNIIKYKKKILNGDLLTKEEVEEILEEDITDLAATANEIRESLCGNKFDLCTIINGKSGRCQENCKYCAQSAHFDTDIIEYNILNSDRIINSAISNYNKGVHRFSVVTSGRALNNNEVDTLCKTYSKLKETCSIRLCASHGLLKYEDLKRLKDSGVTRYHNNLETSRKFFTKICTTHKYDDKIETIKNAKKAGLEICSGGIIGLGETMEDRIDMAFTLRELSVESVPVNILNPIKGTPLENQEILSYEEIIKTLALFRFILPTVQIRLAGGRTIISDNGKKALESGVNGAISGDMLTTLGIETSEDIKMIKNLGFEV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q0ATN3 | MSLLNDIDQLSQVRTDWTRETAGEIYRAPFNDLIFAAQSVHRQCHPANQVQTSQLLSIKTGGCAEDCGYCNQSAHFDTGLKASKLMPLDDVLDAAKKAKDGGATRFCMGAAWRELKTRDEDVICDMISGVKSMGMETCVTLGMLTDSQANKLREAGLDYYNHNLDTAPEDYGRVISTRTYQDRIDTLSRVRGAGIHVCTGGIVGMGEDEAARIGLLTELASMDPHPESVPINHLVAVPNTPLGDSKPLDGIEFVRTIATARILMPRSMVRLSAGREGMSRELQALCFLAGANSIFVGEELLTTPNPEQNEDFDLFKSLGIEPMRLGETGTVPAE | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A6W0Y1 | MSINNISAPRFDWTHAEIKALFDLPFMDLMFRAQTVHRENFAPNEVQVSTLLSIKTGACPEDCKYCPQSGHYNTELEKEKLMEVQKVLEEAALAKEKGASRFCMGAAWKHPSEKDFPYVLEMIKGVKSLGLESCVTLGSLNDDQAKRLSEVGLDYYNHNLDTSAEFYDSIITTRTYQDRLDTLSRVRDSGIKLCCGGIMGMGEEQKDRVGLLRQLSQMTPHPESVPINMLVKVEGTPLENVDDLDTFEFIRTIAVARILMPKSHVRLSAGRQGMNEQTQALCFMAGANSIFYGEKLLTTGNPEADKDMALFANLGINPEKREEHSDAAVAEAIAAQVVKQEESKLFYEASV | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A1U4B2 | MTATATRHDWTLQEARELFNLPFNDLLFRAQSIHREHFDPNEVQVSTLLSIKTGACPEDCKYCPQSGHYNTGLEKEKLLEIEKVVAEARVAREKGASRFCMGAAWRSPSKKDMPYVLDMVRQVKSLGLETCMTLGMLKEEEAKELADAGLDYYNHNLDTSEKYYNHIITTRTYQDRLDTLDNVRKAGMKVCCGGIMGMGEDEDDRVGLLVQLANLPQHPESVPVNMLVKVKGTPLEDVEDLDPFDFIRIIAVARIMMPASHVRLSAGREQMNEQMQALCFMAGANSIFYGEKLLTTSNPEADADMQLFRKLGIRPEQREQCATEEQEEEAIAEAVEYEATRHMFYDATRESA | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
C6C0T2 | MDRNEKQALWNAVHGGGAIDEHTAVSVLGASHGELAEILHAAHTMTMRRFGREVSLCSIANVRSGNCSEDCTFCAQSSHFKGTPAPAYPLMSVEEIRDCAEKAGQSPLEFFSYVTSGRALKGKSLDHVCEAVDGMRERSFNHCASLGCLDFESLKKLHESGVVRYHHNLEAAESYFPNVCTTHSYEERVRTVRDAKKAGLEVCCGGLLGLGESHQQRVELALALAELEVDSIPLNFLIPIPGTPLENVEPLQPLEILLTIAMFRLVNPHAEVRMAAGRAALRSLQSFIFHAGCNGLMVGDFLTVSGQGIDHDLTMLEDLGLTVRTKK | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A6UTF3 | MEEFTGIGYFYKKSIKNQLDKKDASLLWELPYYTLLYLANCVKKHNNSNNIDLCSIINAKSGLCSENCAFCSQSLHNSSKIKEYPLKPKEDILKQAKYIEKYSNRFSIVVSGKTVNDREYNEIIDAIKDIKKETNLKVCASLGLLDNSQLKELKDLDVRIHNNLETSKEYFDKICTTHTYDDKVKSITMAKKIGLEVCSGGIIGLGESLENRINLFYELKELDVEGIPINIYNPIKGTKTYELLNNNAIKQITPIEALKSIAICKLILPNKDVRLCGGREYNLRDWQSLSLLAIDGLMIGNYLTTNGRNIEDDIKMIVDGGFDGK | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B7KN34 | MSDTVVSLTASPAAIRHDWTLAEIQAIHDMPLLDLVHRAGVVHRAHNDPADIQRAALLSIKTGGCPEDCAYCPQSAHHKGANLPRERLMPVDAVLKEAAAAKANGAHRFCMGAAWRKPKDGPDFDAVLEMVRGVRGLGMEACVTLGMLTQSQAQRLAEAGLTSYNHNLDTGPEFYGDIISTRTYDDRLQTLEHVRQAGIGVCCGGIVGMGERVRDRAEMLLVLANHAPHPESVPINALVAVEGTPLEDRPPIDPLDLVRMCATARIVMPKARVRLSAGRKSLTREAQILCFLAGANSIFYGERLLTTANNEADADAELLRDIGVPVPEVTLAAAE | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q609V2 | MTNQERAEEPVLRHDWTQGEAEALFALPFNELLFQAQTIHRRHFDPNEVQVSSLLSIKTGACSEDCAYCPQSAHYETGVKRESLMSLEDVLEAAQRAREEGATRFCMGAAWRSPRDGDLEAIAAMVEGVKALGMETCVTAGMLSDEQARRLKEAGLDYYNHNLDTSESYYGEIITTRTYQDRLDTLQRVRDAGMHVCCGGIVGMGESAADRAGLLIGLANLPRHPESVPINLLVRVEGTPLADTAALDPFDFVRTVAVARIMMPASRVRLSAGRSDMSDEMQALCFLAGANSIFYGDRLLTTENPQAQRDRRLFARLGLRMAGLGC | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A9W8M8 | MSDTVVSLTASPAAIRHDWTLAEIQAIHDMPLLDLVHRAGVVHRAHNDPADIQRAALLSIKTGGCPEDCAYCPQSAHHKGANLPRERLMPVDAVLKEAAAAKANGAHRFCMGAAWRKPKDGPDFDAVLEMVRGVRGLGMEACVTLGMLTQSQAQRLAEAGLTSYNHNLDTGPEFYGDIISTRTYDDRLQTLEHVRQAGIGVCCGGIVGMGERVRDRAEMLLVLANHAPHPESVPINALVAVEGTPLEDRPPIDPLDLVRMCATARIVMPKARVRLSAGRKSLTREAQILCFLAGANSIFYGERLLTTANNEADADAELLRDIGVPVPEVTLAAAE | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q1GZA6 | MRDSVIDIRGLDRVQRARVQAKEEAPKRWSVDDIVALFELPFSDLMHRAQSVHRENFDPNGVQVSTLLSIKTGGCSEDCGYCPQAARYHTDVEKQDLMQLEEVLAAARAAKENGASRFCMGAAWRSPKQRDLEPVLAMIREVKAMGLETCATLGMLKDGQAEQLKEAGLDYYNHNLDTAPEYYGEVITTRTYQDRLDTLDRVREQDINVCCGGIIGMGESRVQRAGLLAQLANMERPPESVPINLLTQVEGTPMYGMDELDPFEFVRTIAAARITMPQSFVRLSAGRQSMHEGIQALCFLAGANSIFYGEKLLTTGNPEAEADRKLFDKLGIHPL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B3DV36 | MKDYCAIEQIYHRPLDELLGEALQAKKLSGRNGVQFCQLLNIKSGGCSEDCKYCAQSAHYRTPIEKGALLDEEEILQAGLQAKEKGASRFCLGAAWRGLFEGETKTKKICKIISKISSLGMELCLSAGFLTEKTALMLKESGLKVYNHNLNTGPSYYPRIASTHRFEDRLQTIRIVQKVGLKLCSGGIIGMGERLKDRLEMLFCLYSLPEAPESIPINVYMPIEGTPFYGTPPLDYMDLIRMIATTRILFPLSRIRLAAGRKLLDEKTLTLCYLAGVDSIFIGEKLLTQSNVQLEKDYALLKKLNLRKEER | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q58692 | MIFMEIETFLKKSLKNKIDFDDALYLYNNFSAIDLLYLAFKIKNRIKNNSKIKLCAIINAKSGKCKEDCIFCSQSIYSKCNIPIYPLKSKKEILEYAKKIIDECSKISSSIERGTLIGAESPNLMDVGYPNRGFPLWVERFSIVTSGKKINDDEFIEIVEAIELIKEETNLKVCCSLGLLDREKLKELKKLDVRIHNNLEASKNYFKNICSTHSYEDKVKVIKEAKKLDLEVCSGGIFGLGESVEERIKMAFELKELGVDSVPINILHPIEGTKAYEKIKNGEIKPISVSDALKLIALYKIIMPYAEIRLAGGRIYNLRDFQSYALMVLDGLMVGNYLTTKGRCLEDDLKMIADFHSL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A4FWU0 | MKEIKLNSDSLEIYEKSASKKLNRNDLIDLWNLDLNDLLDISYALKKLFNKDKIDLCSIMNAKSGICPENCIFCSQSKHNSSKIDTYELKSKEEILKNAKSVEKYSNRFSIVVSGKTVTDLEFEKIIESIEEIQNKTKLKVCVSLGLLNKDQLKALNEKNVRIHNNLETSENYFKNICTTHDYNDKIKVILEAKKIGLEMCSGGIFGMGESIDDRINLFLDLKKLGVDSIALNLLNPIYGTKIYDRINSGDISPINSIGALKSLCIARITLPNKVIRLCGGREHVLKDMQKYSLLAIDGLMIGNYLTTNGQNIQSDLKMIEEMGFER | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A9AA75 | MREIKLNPDSLEIYEKSDSGKLNRNDLIDLWNLDLNDLLNISCALKKLFNKDKIDLCSIMNAKSGICPENCIFCSQSKHNTSKIDTYELKSKEEILKNAKSVEKYSNRFSIVVSGKTVTDLEFEKIIESIEEIQNKTKLKVCVSLGLLNKDKLKALKEKNVRIHNNLETSENYFKNICTSHDYNDKVKVILEAKKIGLEMCSGGIFGMGESIEDRVDLFLDLKKLGVDSVALNLLNPIYGTKIYEKIKFGVISPINSIDALKSICIARIALPDKVIRLCGGREHVLKDMQKYSLFALDGLMIGNYLTTNGQNIQSDLKMIKEMGFER | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A6VGH7 | MKEIELNSDSLEIYEKSASEKLNKKDLVDLWNLDLKNLLDISYSLKKLFNKEKIDLCSIMNAKSGVCSENCIFCSQSKHNSSKIDTYELKSKEEILKNAKSVEKYSNRFSIVVSGKSVTDLEFENIIESIEEIQNKTKLKVCVSLGLLNKDKLKALKEKNVRIHNNLETSENYFKNICTSHDYIDKIKVILEAKKMGLEMCSGGIFGMGESVADRVDLLLDLKKLDVDSVALNLLNPICGTRIYDKINSGEFIEINHTDALKSICIARIALPKKVIRLCGGREHVLKDMQKYSLYVLDGLMIGNYLTTNGQNIQSDLKMIDEMGFKQ | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q6LXV8 | MKEIKLNSDSLEIYEKSVSEKLNRNDFIKLWDLDLNDLLDISYNLKKLFNKEKIDLCSIMNAKSGICPENCIFCSQSKHNTSKIDTYGLKSKEEILKNAKSVEKYSNRFSIVVSGKTVTDLEFEKIIESIEEIQNKTKLRVCVSLGLLNKDKLKALKERNVRIHNNLETSENYFKNICTSHDYSEKIKVILEAKKIGLEMCSGGIFGMGETIEDRVDLFLDLKKLGVDSVALNLLNPIYGTKIYEKIKSGDISPINSTDALKSICIARIALPNKVIRLCGGREHVLKDMQKYSLLALDGLMIGNYLTTNGQNIQSDLKMIEEMGFER | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B8IU36 | MTTTTERPDAPIRHDWTVAEIQAIYDLPLLDLVHRASLVHRAHHDPADIQRASLLSIKTGGCPEDCAYCPQSAHHKEAGIGRQRLMPVEAVLREAEAAKAAGATRFCMGAAWRQPKDGPEFDAVLAMVRGVRGLGMEACVTLGMLTPSQAERLAEAGLTAYNHNLDTGPDFYGDIISTRTYADRLNTLQAVRDAGIGVCCGGIIGMGEGVADRAAMLQVLANHAPHPESVPINALVAVAGTPLAERPPVDPLDLVRMCATARIVMPKARVRLSAGRRALTREAQVLCFLAGANSIFYGERLLTTANNEADADAQLLRDIGVPVPGIEVLEAAE | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B1ZFX7 | MSDTVVSLASSQAPDAVRQDIRHDWTLAEIQAIHDMPLLDLVHRAGTVHRAHNDPADIQRAALLSIKTGGCPEDCAYCPQSAHHKGANLPRERLMPVDAVLKEAAAAKANGAHRFCMGAAWRKPKDGPEFDAVLEMVRGVRGLGMEACVTLGMLTQSQAQRLAEAGLTSYNHNLDTGPEFYGDIISTRTYDDRLQTLEHVRQAGIGVCCGGIVGMGERVRDRAEMLLVLANHAPHPESVPINALVAVEGTPLEDRPPIDPLDLVRMCATARIVMPKARVRLSAGRKSLTREAQILCFLAGANSIFYGERLLTTANNEADADAELLRDIGVPVPEVTLAAAE | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A2SGQ6 | MTATQPVHLVRPAPVHVHPSSERWSVEAIEALFALPFNDLIFRAQQVHREHFDANAVQRSTLLSIKTGGCPEDCAYCPQSVHHDTGVEADKLMDVATVRQAAQAAAAAGATRFCMGAAWREPKDRDIEKVVELVREVKSLGLEACCTLGMLSKPQAQALKEAGVDYYNHNLDTAPEAYGRIISTRVYEERLQTLAHVRDAGMNVCCGGIVGMGESRRERAGLVAQLANLDPHPESVPINELVQVEGTPLAGSDKLDPFEFVRTIAVARITMPTAYVRLSAGRQEMGDAIQALCFLAGANSIFYGDKLLTTGNPDVERDEALFERLGLTSA | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B1LV19 | MSATSLPGSQQPDLGEIRHDWSVAEIRAIHDLPLMDLVFRAAQVHRRHNDPADIQRASLLSIKTGGCPEDCAYCPQSAHHKGAGVARERLMPVETVLAEAAAAKAAGAQRFCMGAAWRQPKDGPEFDAVLAMVRGVRGLGMEACVTLGMLTPSQAGRLAEAGLTSYNHNLDTGPDFYEDIISTRTYDERLQTLANVREAGIGVCCGGIVGMGEGVTDRAAMLQVLANHAPHPESVPINALVAVPGTPLEDQPAVDPFDLVRMCATARIVMPRSRVRLSAGRKSLTREAQVLCFLAGANSIFYGERLLTTANNGQDDDAALLADLGIRVGEPVRAAAE | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B0U811 | MTTTERSDPAIRHDWTVAQVQAIHDMPLLDLVHRASLVHRAHHDPSDIQRASLLSIKTGGCPEDCGYCSQSAHHKETGVARQRLMPVEAVLREAAAAKAAGATRFCMGAAWRSPKDGPDFDAVLAMVRGVRGLGMEACVTLGMLTPSQAERLAEAGLTAYNHNLDTGPDYYDKIVSTRSYEDRLATLQAVRDAGIGVCCGGIIGMGEGVTDRVAMLQVLANHAPHPESVPINALAAVPGTPLGERPPVDPFEMVRMCATARIVMPRARVRLSAGRRALSREAQVLCFLAGANSIFYGERLLTTANTDADADAQLLRDIGVPVPAISALEAAE | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
P12678 | MARHPRWTLSQVTELFEKPLLELLFEAQQIHRQHFDPQQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLMEVEQVLDSARKAKNAGSTRFCMGAAWRNPHERDMPYLEKIVQGVKAMGLETCMTLGMLNESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVREAGIKVCSGGIVGLGETVTDRAGLLLQLANLPTPPESVPINMLVKVKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPAEDKDLQLFRKLGLNPQQTRVLAGDNEQQQRLEQTLMTPDTDDYYNAAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
O60050 | MFTRTIRQQIRRSSALSLVRNNWTREEIQKIYDTPLIDLIFRAASIHRKFHDPKKVQQCTLLSIKTGGCTEDCKYCAQSSRYNTGVKATKLMKIDEVLEKAKIAKAKGSTRFCMGSAWRDLNGRNRTFKNILEIIKEVRSMDMEVCVTLGMLNEQQAKELKDAGLTAYNHNLDTSREYYSKIISTRTYDERLNTIDNLRKAGLKVCSGGILGLGEKKHDRVGLIHSLATMPTHPESVPFNLLVPIPGTPVGDAVKERLPIHPFLRSIATARICMPKTIIRFAAGRNTCSESEQALAFMAGANAVFTGEKMLTTPAVSWDSDSQLFYNWGLEGMQSFEYGTSTEGEDGTFTLPPKERLAPSPSL | Catalyzes the last step of biotin biosynthesis, the conversion of dethiobiotin to biotin. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Belongs to the radical SAM superfamily. Biotin synthase family. |
P36569 | MADRIHWTVGQAQALFDKPLLELLFEAQTVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQSPRYKTGLESERLMQVEQVLESARKAKANGSTRFCMGAAWKNPHERDMPYLQQMVQGVKAMGMETCMTLGTLDGTQAERLAEAGLDYYNHNLDTSPEFYGSIITTRSYQERLDTLDKVRDAGIKVCSGGIVGLGETVRDRAGLLVQLANLPKPPESVPINMLVKVKGTPLADNDDVDPFDFIRTIAVARIMMPSSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPEEDKDLQLFRKLGLNPQQTATEHGDNQQQQVLAKQLLNADTAEFYNAAP | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A8GBC5 | MADRIHWTVGLAQTLFDKPLLELLFEAQTVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLESERLMQVEQVLESARKAKANGSTRFCMGAAWKNPHERDMPYLQQMVQGVKAMGMETCMTLGTLDGTQAERLADAGLDYYNHNLDTSPEFYGNIITTRSYQERLDTLGKVRGAGIKVCSGGIVGLGETVRDRAGLLVQLANLPTPPESVPINMLVKVKGTPLADNEDVDPFDFIRTIAVARIMMPASYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPEEDKDLQLFRKLGLNPQQTETEHGDNQQQQALAAQLMQADTAEFYNAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A1S5I9 | MSSFAVRHDWSRQEVEALFALPMNDLLFRAHSIHREVFDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLEIEKVLTEARAAKDAGATRFCMGAAWRNPHERDMPYLTDMVKEVKSMGLETCMTLGMLSAHQANQLAEAGLDYYNHNLDTSPEFYGDIITTRTYQDRLDTLSNVRAAGMKVCSGGIVGMGEQATDRAGLLQQLANLEQHPDSVPINMLVKVTGTPLDSVDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEENDDMSLFRRLGLKPEQGKAAIVEEDAAVVARAAREQQAEGEAKTKPLFYDAAN | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B8EAJ2 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKEKDMPYLKQMVQEVKALGMETCMTLGMLSEDQANDLASAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLTNVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAAKLEEESAVLAKAAAYQDKSSAQFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A3D3F2 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKEKDMPYLKQMVQEVKALGMETCMTLGMLSEDQANDLASAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLTNVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAAKLEEESAVLAKAAAYQDKSSAQFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A6WM55 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKEKDMPYLKQMVQEVKALGMETCMTLGMLSEDQANDLASAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLTNVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAAKLEEESAVLAKAAAYQDKSSAQFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A9KY60 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKEKDMPYLKQMVQEVKALGMETCMTLGMLSEDQANDLASAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLTNVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAAKLEEESAVLAKAAAYQDKSSAQFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q12NN4 | MSLFEVRHDWKKAEIEALFALPMNDLLFKAHTIHRESFDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLEIEKVLTEAKSAKAAGASRFCMGAAWRNPRDRDMPYLTQMVKDVKALGLETCMTLGMLSTEQSQKLAGAGLDYYNHNLDTSPEYYGDVITTRTYQSRLDTLSNVRASGMKVCSGGIVGMGEKASDRAGLLQQLANLEQHPDSVPINMLVKVAGTPFEKIDDLDPLEFVRTIAVARIIMPKSRVRLSAGREKMSDELQSMCFFAGANSIFYGCKLLTTANPEENDDMSLFKRLGLRPEQGPAAPVAQVATNLDQEQALIAKASALNEKATQQFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q084I8 | MSLAEVRHDWQKAQIEALFALPMNDLLFKAHSIHRETFDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLEIDKVLTEAKSAKAAGASRFCMGAAWRNPRDKDMPYLTQMVKDVRALGMETCMTLGMLSSEQAGKLADAGLDYYNHNLDTSPEYYGDVITTRTYQSRLDTLTNVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLEQHPDSVPINMLVKVAGTPFENIDDLDPLEFVRTIAVARILMPKSRVRLSAGRESMSDELQSMCFFAGANSIFYGCKLLTTPNPEENDDMSLFRRLGLHPEQGPQANIENDSALLAKASAKQDKSTKQFFDAAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B0TJN8 | MSEVQLRNNWKREEIESLFALPMNDLLFQAHSIHRQEFDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKERDMPYLKTMVEEVKALGMETCMTLGMLSAEQANTLADAGLDYYNHNLDTSPEYYGDVITTRTYQSRLDTLSNVRASGMKVCSGGIVGMGEKATDRAGLIQQLANLDQHPDSVPINMLVKVEGTPFEKLDDLDPLEFVRTIAVARITMPKSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEENDDMGLFRRLGLHPEQGVASTKEQDEAMLAKAAAQQDKKVSAFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A3QDN8 | MSELALRHDWQRDEIEALFALPMNDLLFKAHSIHRQHFDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLIEIEKVLTEARAAKAAGASRFCMGAAWRNPHERDMPYLKDMVSEVKAMGMETCMTLGMLSESQAKDLADAGLDYYNHNLDTSPEYYGDIITTRTYQDRLNTLDNVRAAGMKVCSGGIVGMGEQASDRAGLLQQLANMAKHPESVPINMLVKVAGTPFENLDDLDPLEFVRTIAVARIVMPLSRVRLSAGREKMTDELQAMCFFAGANSIFYGCKLLTTSNPEENEDMTLFKRLGLHPEQGKAGTVEEDKAVFAKAQAVKDKASQPFYDAAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q8EDK6 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREEYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKDKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELAEAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAASIDDEQAVLAKAAAYQDKASAQFYDAAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A8H3I7 | MPEVQLRNNWKREEIEALFALPMNDLLFQAHSIHRQEFDPNEVQVSRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKERDMPYLKTMVEEVKALGMETCMTLGMLSAEQANTLADAGLDYYNHNLDTSPEYYGDVITTRTYQSRLDTLTNVRASGMKVCSGGIVGMGEKATDRAGLIQQLANLEQHPDSVPINMLVKVEGTPFEKLDDLDPLEFVRTIAVARITMPKSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEENDDMSLFKRLGLHPEQGIAATKEQDEAMLAKAAAHQDKKSAAFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A4Y7Y3 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKEKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELADAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLTHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAVATLDDEQAVLAKAAAHQDKSTAQFYDAAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
B8CQY2 | MSDVQVRNNWKRDEIETLFALPMNDLLFQAHSVHRQEFDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKERDMPYLKTMVEEVKSLGMETCMTLGMLSADQASELADAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSNVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLDKHPDSVPINMLVKVEGTPFEKIDDLDPLEFVRTIAVARIIMPKSRVRLSAGRENMTDELQAMCFFAGANSIFYGCKLLTTPNPEENDDMSLFRRLGLHPEQGIAATKEQDEAMLAKAAAQQDKKASAFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A0KY79 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKDKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELADAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPKSRVRLSAGRENMTDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAATIDDEQAVLAKAAAHQDKASAPFYDAAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
A8FX10 | MSDIQLRHDWKHDEIEALFALPMNDLLFKAHSLHRQVFDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLIEIEKVLTEARSAKAAGASRFCMGAAWRNPHARDMPYLKDMVSEVKAMGMETCMTLGMLSGTQAEELAEAGLDYYNHNLDTSPEYYGEIITTRTYQDRLDTLSNVRSAGMKVCSGGIVGMGEQASDRAGLLQQLANMEQHPDSVPINMLVKVAGTPFENLDDLDPLEFVRTIAVARIIMPHSRVRLSAGREKMTDEMQAMCFFAGANSIFYGCKLLTTNNPEENEDMTLFKRLGLHPEQGKYATVEDDKEVMAKASAKANAIKDKQSGAFYDAGAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q0HHN7 | MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKDKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELADAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPKSRVRLSAGRENMTDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAATIDDEQAVLAKAAAHQDKASAPFYDAAAL | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. Homodimer. Belongs to the radical SAM superfamily. Biotin synthase family. |
Q8Z890 | MTKRYFVTGTDTEVGKTVASCALLQAATQLGYQTVGYKPVASGSEMTTDGLRNSDALALQRNSSLPQPYSAINPYTFAEPTSPHIASADEGRAIDAAVLSRGLRTLEAQADWVLTEGAGGWFTPLSATLTFADWVQTEQLPVILVVGVKLGCINHAMLTALAVEQAGLPLVGWIANDMQPPGARHGEYLATLRRVIPAPLLGEIPWLGVSPSQAATGQYLDLSPLERA | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q8ZQQ5 | MTKRYFVTGTDTEVGKTVASCALLQAATQLGYQTVGYKPVASGSEMTTDGLRNSDALALQRNSSLPQPYSAINPYTFAEPTSPHIVSADEGRAIDAAVLSRGLRTLEAQADWVLTEGAGGWFTPLSATLTFADWVQTEQLPVILVVGVKLGCINHAMLTALAVEQAGLPLVGWIANDIQPPGARHGEYLATLRRVIPAPLLGEIPWLGVSPSQAATGQYLDLSPLERA | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q0WHP5 | MTKRWFITGTDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQANSSQRLGYSQVNPFTFLEATSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGGWFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTAQAIQHAGLTLAGWVANEVTPAGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. Extended N-terminus. Extended N-terminus. |
Q8X788 | MLKRFFITGTDTSVGKTVVSRALLQALASQGKTVAGYKPVAKGSKETPEGLRNKDALVLQSVSTIELPYEAVNPIALSEEESSVAHSCPINYTLISNGLANLTEKVDHVVVEGTGGWRSLMNDLRPLSEWVVQEQLPVLMVVGIQEGCINHALLTAQAIANDGLPLIGWVANRINPGLAHYAEIIDVLGKKLPAPLIGELPYLPRAEQRELGQYIRLAMLRSVLAVDRVTV | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q7VL12 | MGKIIFVSGIDTDIGKTIATGFYAKRLMQQGFSVITQKMIQTGCQHISADIIKHRQLQGIELTAEDLNGITCPYLFRYPCSPHLAAEMENNPILPSKIAQASALLAQKYDYVLLEGAGGLAVPYNSQQTTLDYIVEQQLPLILVTSAKLGSINHTLLSLIVCQQHKIEMEAVIYNTYPLEDEKIAKSTQLYLQQYIKQHFPNTEFLVMDRQ | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
P45248 | MGKVIFISGIDTDVGKTIATGIYAKKLMEQGCSVITQKMIQTGCKNIADDLLVHRKIQGIDLTEEDLQGKTCPYVFEYPCSPHLAAKRESRKIEAKIIEKSTALLAEKYDYVLLEGAGGLMVPYCEEATTLDYIQLNNYPLILVTSGKLGSINHTLLSLEACRTRGISVLSVMYNGYPEYDLLLVKKPNAI | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q9CJT7 | MAKVFFITGIDTDIGKTIATGWYAKKLMQQGASVITQKMIQTGCRGIAEDLLTHRKIQGIELTEEDKQGITCPYVFDYPCSPHLAAKLEQRTIERKKIETCTALLCEKYDYVLLEGAGGLCVPYNEEETTLDYLCQHQYPVILVTSGKLGSINHTLLSLQVLNSKRVSVHAVIYNLYPETDQVISQETQHFLRRYLEKYSPNTLFEVMDLISV | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q8Z6X9 | MLKRFFITGTDTSVGKTVVSRALLQALSSGGKSVAGYKPVAKGSKETPEGMRNKDALVLQSVSSLELPYEAINPIALSEEESSVAHSCPINYTLLSNGLASLSDKVDHVVVEGTGGWRSLMNDLRPLSEWVVQEQLPVLMVVGIQEGCINHALLTAQAVANDGLPLIGWVANRINPGLAHYAEIIDVLGKKLPAPLIGELPYLPRAEQRELGQYIRLSMLGSVLAVDRIMA | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q8ZPK6 | MLKRFFITGTDTSVGKTVVSRALLQALASSGKSVAGYKPVAKGSKETAEGMRNKDALVLQSVSSLELPYEAINPIALSEEESSVAHSCPINYTLLSNGLASLSDKVDHVVVEGTGGWRSLMNDLRPLSEWVVQEQLPVLMVVGIQEGCINHALLTAQAVANDGLPLIGWVANRINPGLAHYAEIIDVLGKKLPAPLIGELPYLPRAEQRELGQYIRLSMLGSVLAVDRIMA | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q9AGD4 | MLTRLFVTGTDTAVGKTVVSRALLQALSQNGRTAVGYKPVATESKETSEGLRNQDALILQASSSIELNYQEVNPYPLQGDVIHACTDTLINYEKMTEGLQCLSAKADTVIVEGCGGWKVMMNDQRFYSDWVVQEQLPVILVVGIKLGCINHALLTAQAIINDGLPLLGWVANRINPGLAHYAETIAMLRDRLAAPQLGQLPYLPRPEEKPLAKYLDLTAISG | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q9FKL5 | MIPVTATLIRHRLRHLRHRIRFKSTSVSPFHLPLNHPTYLIWSANTSLGKTLVSTGIAASFLLQQPSSSATKLLYLKPIQTGFPSDSDSRFVFSKLDSLSLRRQIPISISNSVLHSSLPAAKSLGLNVEVSESGMCSLNFRDEKTVTGAPELLCKTLYAWEAAISPHLAAERENATVEDSVVLQMIEKCLKEEMECGVKSEKSDLLCLVETAGGVASPGPSGTLQCDLYRPFRLPGILVGDGRLGGISGTIAAYESLKLRGYDIAAVVFEDHGLVNEVPLTSYLRNKVPVLVLPPVPKDPSDDLIEWFVESDGVFKALKETMVLANLERLERLNGMAKLAGEVFWWPFTQHKLVHQETVTVIDSRCGENFSIYKASDNSSLSQQFDACASWWTQGPDPTFQAELAREMGYTAARFGHVMFPENVYEPALKCAELLLDGVGKGWASRVYFSDNGSTAIEIALKMAFRKFCVDHNFCEATEEEKHIVVKVIALRGSYHGDTLGAMEAQAPSPYTGFLQQPWYTGRGLFLDPPTVFLSNGSWNISLPESFSEIAPEYGTFTSRDEIFDKSRDASTLARIYSAYLSKHLQEHSGVRQSAHVGALIIEPVIHGAGGMHMVDPLFQRVLVNECRNRKIPVIFDEVFTGFWRLGVETTTELLGCKPDIACFAKLLTGGMVPLAVTLATDAVFDSFSGDSKLKALLHGHSYSAHAMGCATAAKAIQWFKDPETNHNITSQGKTLRELWDEELVQQISSHSAVQRVVVIGTLFALELKADASNSGYASLYAKSLLIMLREDGIFTRPLGNVIYLMCGPCTSPEICRRLLTKLYKRLGEFNRT | Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate Shoulder at 335 nm (at pH 7.5 and 30 degrees Celsius). kcat is 0.072 min(-1) for 7,8-diamino-pelargonic acid aminotransferase + dethiobiotin synthetase activities, and 1.85 min(-1) for 7,8-diamino-pelargonic acid aminotransferase activity only (at pH 7.5 and 30 degrees Celsius). Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1. Homodimer. Only the isoform BIO3-BIO1 is detected at protein level in mitochondria. Arrested embryos at the transition to cotyledon stages of development (PubMed:11779812, PubMed:17993549). Biotin depletion leading to lethality; this phenotype is rescued by exogenous supply of biotin (PubMed:12644697, PubMed:23031218). May be due to a competing acceptor splice site. May be due to a competing acceptor splice site. May be due to an intron retention. In the N-terminal section; belongs to the dethiobiotin synthetase family. In the C-terminal section; belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. Was originally thought to correspond to two different genes At5g57590 and At5g57600. Was originally thought to correspond to two different genes At5g57590 and At5g57600. |
C8V1D0 | MAPVGAALWRSLRAHQVYGANTDVGKTIVSTFLCNAVNRLKNQGKSAFLKPVSTGPLDEADDRHLQRHAPNTLTKCLYQFDEPVSPHIAAKTFAIPRDDEILSSVHRTLSDWANDGVGFALVETAGGVHSPGPNGNSQADLYRPLRLPIILVADSRLGGISSSISAYESLLLRGYDVHSVLLFKDDYYQNHEYLGNYFRGKSIPLVPVPAPPRRPQEQDPDSRARDLEALDKYYSSVTKSTDVVSLLDELVLKNKQRVEYLDEMASRAQKTIWYPFTQHHGMAAKDITPIDSAYDDFFQTYVTADRSAQQGRLQATFDGSASWWTQGLGHGNPGLALSAAYAAGRYGHVMFPGNIHEPALALAESLLKTVDNPRLQKVFYTDNGSTGMEVALKMGLRAACDRYGWDASKEQINILGLKGSYHGDTIGVMDCSEPSTYNQRVEWYRGRGHWFDFPLVKMSQGVWQVEVPATLQASLGGNQQFSSLDAVFDVESRVRSDAGQRYRKYILETIERLVTQEGKKFGALIMEPIILGAGGMLFCDPLFQRCLADVVRGNPQLFNRGRLTEPQPQTDLSWSGLPVIFDEVFTGLYRLGRKSSASFLGVNPDIAVNAKLLTGGLVPLCTTLASNEIFNAFTSPEKRDALLHGHSYTAHAVGCQVALDSLRTMNNMDEDGSWNDFKNDWKQPHAGDTARVWSVWSHKLLHNLSHAESVDGVFAIGSVLSISLKDAEGAGYTSTAAKGLQTRLAAGGPQFNVHSRVLGNVLYLMSSVTSKQETLRTIEGILREALL | Bifunctional enzyme; part of the cluster involved in the biosynthesis of biotin (also known as vitamin B8 or vitamin H), a water-soluble vitamin that functions as a prosthetic group of many carboxylases, such as acetyl-CoA carboxylase and pyruvate carboxylase (PubMed:20713166). Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (PubMed:20713166). Catalyzes also the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (PubMed:20713166). It is the only animotransferase known to utilize SAM as an amino donor (By similarity). (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1. Homodimer. Expression is increased when transferring biotin auxotrophic mutant mycelia from biotin-supplemented medium to biotin-deficient medium. Recovery of biotin-prototrophic clones from transformation of biotin-auxotrophic mutants suggests that bioDA could be usedas a new and convenient genetic marker for transformation. In the N-terminal section; belongs to the dethiobiotin synthetase family. In the C-terminal section; belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. |
A0A0P0XDC2 | MLRLLRHARRHSTSSSSSAAAAAVPLTSPAFAVFGANTGVGKTLVSAGLVASLLASPSPSPSTVAYLKPLQTGFPDDSDARFVFDRAPALLRRLRLAGGGASTRLVASNHTLFPSPAVDPLPERQDTVVNYGGEEGVEEKALVCRTVYAWREPVSPHLAAEREGMPVEDEEVRWLVDRWLAEEDGGGEVWKVLETAGGVASPGPSGTLQCDLYRSSRLPAVLVGDGRLGGISSTLSAYETLLLRGYDVGSVILEDRGLSNDRFLLSYLRKRVPVHVLPPIPEDPKDDLTDWFSESSSAFSSLKDSLQSFHSRRVQRLNSMQRKSKYLLWWPFTQHDLVPVDSVTVIDSRFGENFSAYKVKDKTIVPQFDACASWWTQGPDSNLQIELARDMGYAAARYGHVMFPENVHEPALRCAELLLGGVGKDWASRVYFSDNGSTAIEIALKMAFRKYACDHGIIVDSEKDIRSEGSVHFKVLALNGSYHGDTLGAMEAQAPSAYTSFLQQPWYSGRGLFLDPPTVYIKNKSANLSLPPSIMHDQLSSCDTCFSSLTEVFCKTRDTSSAANVYVSYISQQLSQYAMSNNSEHIAALIIEPVIQGAGGMHLIDPLFQRLLVKECKNRKIPVIFDEVFTGFWRLGVESASELLGCFPDISCYAKLMTGGIVPLAATLATEPIFEAFRSDSKLTALLHGHSYTAHPMGCTAAVKAIQWYKDPSTNSNIDLDRMKLKELWDSALVNHLSSLPNVKRVVSLGTLCAIELKAEGSDAGYASLYASSLIRQLREEDNIYARPLGNVIYLMCGPCTTQDSCTRQLAKVHRRLQKLN | Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor (By similarity). (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1. In the N-terminal section; belongs to the dethiobiotin synthetase family. In the C-terminal section; belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. |
A5FZN7 | MSHFFITASGTEIGKTHVAAGMIRHWRAGDVPARALKPVASGYQPALSASSDAGILLRAMGSSMVNDEAVATICPWRFPDPISPDMAAARSGRRIPFDDLVAFCQAEIVGAAGPMLVEGVGGAMVPLDETHTVRDWIAALGIEVVLVAGGYLGTISHTLCAVEALRARGIAIAAVVINPMEPLPVPVERTRESLLRHLGATPPPVFIDDTPDWHAWLDEAARR | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
A6VND6 | MRTFFVTGTDTGVGKTICSRAIIQALQEMDTQIVGFKPIASGQDEPVYADSLDDPKNDYGDEDNRDVLILQNSTKENVSYRDINSYTFLQTVPMITAEKGRIKLEKVDRDLARLAATYDVVAVEGSFGWLSPMNERFTFADWVVKHNMPVIVAVGIKEGCINHALLTVQSVEKMGLPVLGWIANRINPGLSHYAEIIDVLSSKIAAPLLGCIPYIHKPETQDVGKFLTNTEQLRHIQTLLAK | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
A0KIC9 | MVKSFFVTGTDTDVGKTLVARTLLLEFAAHGLRCAGYKPISAGCARTPDGLRNLDAVLLQEAASLPLPYDLVNPYAYEPPIAPHIAASEARDAITLKGLSDGLRQIEQAGAELVVVEGAGGWFLPLDRKHLLSDWVKQENMPVIMVVGAKLGCLNHALLTFAAIRNNNLPVAGWVINRLHGSMSHYQENLDTLRGLLPAPFLGEIPFVNNPLEADLRGRLDISPLL | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
A4SPR4 | MVKSFFITGTDTDVGKTLVARTLLLEFVAHGIQCAGYKPISAGCARTPDGLRNLDAVLLQEAANLSLPYDMVNPYAFEPPIAPHIAASEARDAITLKGLSDGLRQIEQAGAELVVVEGAGGWFLPLDRKHLLSDWVKQENIPVIMVVGAKLGCLNHALLTFAAIRNDNLPVAGWVMNRLYGSMSHYQENLDTLRGLLPAPFLGEIPFVNNPLEADLRGRLDISPLL | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
F8BWJ2 | MSTRLVVSGTDTDVGKTVFSAALAGALDADYWKPVQAGRDDGTDALRVARLSGLPPERILPERYILNTPASPHYAARIDGITIDTNDLTPPPAKDRPLVIEGAGGLMVPINEDTLFIDVFARWKLPLVLCARTTLGTINHSLLSIEAVKRRDIPLVGIAFIGEDYAESERIICKIGGVRHLGRLPPLSPLTPEALRAAFITSFNLSDFTA | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q8U8T9 | MSLRFVISGTDTGIGKTVFAAALTHALEAHYWKPVQSGLEEETDSQTVARLAGASHARILPEAYRLKTPASPHLSARLDNVSIDPARLLPPRPDGPLVIEGAGGLLVPLTDRLLFADIFALWQIPLILCARTALGTINHTLLSLEALRHRAIPVQGVVFIGDEDRENERVITDIGAVRRLGRLPRLPELTPEALHQAFAQHFNLADFLEVPA | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q3BP46 | MQHPAFYVTGTDTGIGKTMGSTALLHALRARGHRAVGMKPVASGCEHTPQGWRNEDALALQAASDPQPDYATLNPYALPAPLAPELAAADVGVTLALEPIAHAFAQLLTQAEVVVVEGVGGWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLQCIGWIANEIDPQMERIEENIGMLRQRLAMPCWGRIPWRPGADAAAQAHGLQLPR | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q4UQI6 | MQFPAFYVTGTDTGIGKTVASTALLHAVRARGHTAVGMKPVASGCVATPQGWHNEDALALQAASQPQPDYATLNPYALPAALAPELAAADVGVTLSLVPLQQALAQLRAQAEVVVVEGVGGWAAPLSAQLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLRCIGWIANEIDPQMERIEDNIRMLGQRLAMPCWGRIPWRPNAQAEGLAQHIRLPE | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
B0RVN9 | MQFPAFYVTGTDTGIGKTVASTALLHAVRARGHTAVGMKPVASGCVATPQGWHNEDALALQAASQPQPDYATLNPYALPAALAPELAAADVGVSLSLVPLQLAFAQLRAQAEVVVVEGVGGWAAPLSAQLDQADLVRTLQLPVVLVVGVRLGCINHARLTAAAIAADGLRCIGWIANEIDPQMERIEDNIRMLGQRLAMPCWGRIPWRPNAQAEGLAQHIRLPE | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q8PCW4 | MQFPAFYVTGTDTGIGKTVASTALLHAVRARGHTAVGMKPVASGCVATPQGWHNEDALALQAASQPQPDYATLNPYALPAALAPELAAADVGVSLSLVPLQLAFAQLRAQAEVVVVEGVGGWAAPLSAQLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLRCIGWIANEIDPQMERIEDNIRMLGQRLAMPCWGRIPWRPNAQAEALAQHIRLPQ | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q2P7M5 | MQPPAFYVTGTDTGIGKTMGSTALLHALRARGHTAVGMKPVASGCERTPQGWRNEDALALQAASNPQPAYATLNPYALPAPLAPELAAADVGVTLSLEPITQAFAQLRAQAEVVVVEGVGGWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLQCIGWIANEVDPQMERVEENIGMLRQRLAMPCWGRIPWRPDAEAAAQAQGLQLPR | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
B2SQ77 | MQPPAFYVTGTDTGIGKTMGSTALLHALRARGHTAVGMKPVASGCERTPQGWRNEDALALQAASNPQPAYATLNPYALPAPLAPELAAADVGVTLSLEPITQAFAQLRAQAEVVVVEGVGGWAAPLSATLDQADLVRALQLPVVLVVGVRLGCINHARLTAAAIAADGLQCIGWIANEVDPQMERVEENIGMLRQRLAMPCWGRIPWRPDAEAAAQAQGLQLPR | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q9PAL9 | MSLSAFYVTGTDTGIGKTFVSCILLHMLRGRGQRAVGMKPVASGCTYSDTGWRNEDALALQAASDPTPAYDLINPYALPAAVAPEIAAIEAGVTVALEPLSAAFTQLRAQADVVVVEGVGGWATPLNATIDQATLVRALEIPVVLVVGLRLGCLNHARLSTTAIMADGLRCIGWIANTIDPHMARIEENLALLRQRLPIPYWGHLPHIPPGINPATLAARLHPQGD | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
B0U3W7 | MSLSAFYVTGTDTGIGKTFVSCILLHMLRGRGQRAVGMKPVASGCTYSDTGWRNEDALALQAASDPTPAYDLINPYALPAAVAPEIAAIEARVTVALEPLSASFTQLRAQADVVVVEGVGGWATPLNATIDQATLVRALEIPVVLVVGLRLGCMNHARLSTAAIMADGLRCIGWIANTIDPHMARIEENLALLRQRLPIPYWGHLPHIPPGINPATLATRLHPQGD | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
Q87BG0 | MSLSDFYVTGTDTGIGKTFVSCILLHMLRGRGQRAVGMKPVASGCTYSDTGWRNEDALALQAASDPTPAYDLINPYALPAAVAPEIAAIEAGVTVALEPLSASFTQLRAQADVVVVEGVGGWATPLNATFDQATLVRALEIPVVLVVGLRLGCMNHARLSTAAIMADGLRCIGWIANTIDPHMARIEENLALLRQRLPIPYWGHLPHIPPGINPATLATRLHPQGD | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
D6W1N2 | MNSKSQQQEQQPIVFVTGTDTDVGKTFVSTLLVHKWKAAYWKPVQTGIESDQGDSETLKNFKIAASTWQPPIFTPTYALQKPLSPLQAMEYEPNVDIRLLDFVVPEEWSAENPLVVEGAGGVCVPITRKLEITTDLIKHLIETSGHPVYVVVVARSGLGTLNHTLLTWNHLCDNGLRSHLFGVILNGEPNEGNVQALKKFGVNIMAQVAQCTTAHDQDMELHELPSVESLMTQQDVE | Dethiobiotin synthetase involved in the biotin biosynthesis pathway. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Belongs to the dethiobiotin synthetase family. |
A9R3D1 | MTKRWFITGTDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQANSSQRLGYSQVNPFTFLEATSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGGWFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTAQAIQHAGLTLAGWVANEVTPAGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM | Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Belongs to the dethiobiotin synthetase family. |
O31777 | MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQLSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEAALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLERVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENGRGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAVTAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAKQFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
A7Z4X1 | MKEFEFLKAELDKMKENKTWQQMKQIETKQGPSVEVKGENVIQLSSNNYLGLTSHPRLVEAAKRAAEEFGAGTGSVRTIAGTFTMHNELEKKLANFKKTEAALVFQSGFTTNQGVLSSILTKEDIVISDELNHASIIDGIRLTKADKKVYRHVDMDDLERVLKKSMNYRMRLIVTDGVFSMDGNIAPLPDIVKLAEAYDAFVMVDDAHASGVLGKNGRGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSQVLIDYLRHKGRPFLFSTSHPPAVTAACIEAIDVLLEEPEHMEKLWENTAYFKDKLVQMGLTLTKSETPIVPILIGEEEKAQALSDLLLTRGVFAQSIVYPTVAQGKARIRTIITAEHTNEELDRALEVIRSAAKELQLV | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
P0A4X4 | MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide (By similarity). Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate. To a lesser extent, can also utilize D-alanine instead of L-alanine as substrate. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Inhibited by D-alanine and D-7-keto-8-amino-pelargonic acid. kcat is 0.007 sec(-1) and 0.0036 sec(-1) with L-alanine and D-alanine as substrate, respectively, and pimeloyl-CoA as co-substrate. Cofactor biosynthesis; biotin biosynthesis. Homodimer. Cells lacking this gene are shown to be highly attenuated in a mouse tuberculosis model (PubMed:14569030). Essential for growth even in liquid culture; growth does not occur on biotin-containing medium after biotin deprivation (PubMed:20565114). Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
Q12F38 | MAINTPLTNSWLDEFPARIAELDRAHLRRRRRVVVPEDGAHLQVDGQRMLAFCSNDYLGLAGHPALVQAACDGARAFGVGAAASPLVSGHSAANEALEAALARFVGQPRALYFYAGYATNIGIVPALVGKGDAIFSDALNHACLIDGARLSSAQIHRYPHADLAALEQELISSPARRKLIISDAVFSMDGDVADVPALLALCERHDALLLLDDAHGFGVLGPQGRGCLAHFGLSGENASPRVLYMATLGKAAGVAGAFVAGSEALVEWLLQKTRSYIFATAAPALLATALQTSLQLIEQDEWRREHLQRLIARLRSGLAQGLQGSSWRLGESPTAIQPVVIGPNDAALAVMEGLRTRGLWVPAIRPPTVAEGTARLRIALSAAHTEADIDRLVQALTELAKPGSL | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
P53556 | MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVWSSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAALLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLENKLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQGTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAAAHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFAEKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
A7Z5B4 | MDFDGWLLGRLDAVKRDGLYRTLRTQETALKTKGQKRQTWASNDYLGLSKDERLITAAQTAMSRFGAGSGGSRLTTGNTVWHEKLEHTIADFKQTEAALLFSSGYLANIGVLASLPQKGDVILSDQLNHASIVDGCRLSKAETIVYRHIDMADLEKKLASVQARNRRFIVTDGVFSMDGTIAPLDRIMALAKQYQAFVIADDAHATGVLGENGGGTSDYFGVCPDVVIGTLSKAVGTEGGFAAGSNIFIDFLLNQARTFIFQTALPPSICAASHTAFDIISDMHDTRRELQSSVKMIKTRLADMGFTVRGGDTPIIPVIIGDAKTAVSAAALLEKKGICAPAIRPPAVPEGESRIRLTVTADRSLQDIDELTEAFDSIRKELNINK | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
Q7DAK0 | MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYPRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] In the C-terminal section; belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
Q9K0U0 | MKVFKQQLEQLGAQNQYRSIPDLIHQGRYITRENRKMLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPALTTTKSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEATLAKAEYLQRQGYYCLPIRPSTVPKNTSRIRLSLTADMTTDEVRQFAACL | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
A1KVF6 | MNVFKQQLEQLGAQNQYRSIPDLIHQGRYITRENRKMLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPALTTTKSLILADKFVHASMIDGIRLSRCAFSRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEAALAKAEYLQRQGYYCLPIRPPTVPKNTSRIRLSLTADMTTDEVRQFAVCL | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
Q0AE73 | MLPDLAEALQQRRQEGLYRFRQVLEGPQSPRVTIDGRDFLAFCSNDYLGLANHPALIEAVAAGAQRYGVGSGASHLISGHSRAHHELEEALAEFVGLPRTLLFSTGYMANMAVVTALMGREDAIFADRLNHASLNDAALLSRARFIRYPHLDLVTLEKQLKTIQARRRLIVTDAVFSMDGDRAPVAELLALCQRFDAWLLLDDAHGFGVLGEQGKGSLYDPQEVERNVPHLIYMATLGKAAGVSGAFVAAQASMIETLIQHSRTYGYTTAAAPLLAHALLTSLQLISQGVWRRERLVQLIEQLRQKLQSLPWQLLLSDTPIQPLLVGGSREAVRLDQALRERGIWVPAIRPPTVPQGMARLRISLSAAHAGEDVDQLSAALHDLAGC | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
Q81ZZ4 | MLADLSEALRERQQEGLYRSRPVLEGPQSPHVTIDGRDFLAFCSNDYLGLANHPALIEAAAEGARCYGVGSGASHLISGHFRAHHELEEALAAFVGLPRTLLFSTGYMANMAVVTALAGRGDAIFADRLNHASLNDAALLSRARFIRYPHLDLDTLARQLETTKARRRLVVTDAVFSMDGDMAPVAELLTLCQRFDAWLLLDDAHGFGVLGERGKGSLYHSQRIERDTPYLIYMATLGKAAGVSGAFVAAQAPVVETLIQHGRTYGYTTAAPPLLAHTLLTSLQLISQESWRRERLALLIERLRQRLHSLPWPLLLSETPIQPLLVGESQEAVRLDLALRERGIWVPAIRPPTVPQGMARLRISLSAVHTEADVDRLGAALRDLAQC | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
Q2Y9Y8 | MLNDLDSIHQTDEGLREYLRSRGNRSLYRYRLTLESPQAPRITVSGREYLAFCSNDYLGLANHPELIAALCEGATQYGVGAGTSHLVSGHSRAHHLLEEALASFTRFPRALLFSTGYMANAGVVTALTGRGDAVFGDKLNHASLNDAALLSRARLSRYPHLDLATLERQLAASPARRKLVISDAVFSMDGDIAPLPELLELCERYDAWLLLDDAHGFGVLGNQGRGSLAHFNISSPRIIYMGTLGKAAGVFGAFVAAQEEIIETLIQCARSYIYTTATPPFLSHALLKSLELIAGGAGRREKLAQLTKLLKQECHPLRWQLLPSDTPIQPLVMGENAEALQVSEALRQKGILVTAIRPPTVPEGTARLRISLSSSHDIEDVMELGAALREIDRDME | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
Q3J9D6 | MELRQRQTQSLYRYRRVLEGPQGAELQMDGRRILAFCSNDYLGLANHPATRAAFMQGVREYGVGSGAAHLVTGHSRAHHTLEEALAAFVGRPRVLLFSTGYSANLGVISALIGRQDAVFEDRLNHASLLDGGLLAGARFKRYRHRDYQSLEAALTATKARRRLVVTDGVFSMDGALAPLPDLAAVADRFDAWLMVDDAHGLGVLGEEGRGSVAHFGLGMAQAPILVGTLGKALGTFGAFVAGEEALIETLIQQARTYIYTTAPPSAVAVATLASLRLVETESWRRDKLTRLIAQFRQGAAQLGLQLVDSPTPIQPLLVGDAGAAVKLSERLLAQGILVTAIRPPTVPEGSARLRITLTAAHSEAQVARLLESLVQVL | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
B2J1W1 | MNFEFGAKRRDPYAWLEQSLATIHRADWYRSVQPINGRPGATVVLAGQEVINFASNDYLGLAGDKRLMAAATAAIAEFGTGSTGSRLLSGHRELHRELEKAIASTKQTEDALVFSSGYLANLGAITALVGKRDLILSDQYNHSSLKNGAILSGAAVVEYPHCDVAVLKTQLSQQRQNYRRCLILTDTVFSMDGDLCPLPALFDLADEFSCMLLVDEAHATGVLGKTGAGCVEYFGCTGKQLIQIGTLSKALGSLGGYVAGSSALIDFLRNRAPSWIYTTGLSPADTAAALAAIKIVQQEPQHLAQLWRNIHYLKTLLQQLPNLKLLPSESPILCFQLPNATDALKAGKQLRDAGIFAPAIRPPTVPTSRIRISVMATHKVAHIEKLVAALKDVI | Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] Cofactor biosynthesis; biotin biosynthesis. Homodimer. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. |
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