UniProt ID
stringlengths
6
10
Protein Sequence
stringlengths
2
35.2k
Functional Description
stringlengths
5
30.7k
A0A1L9WN42
MLLPSFPVTGVATALLLRNAVHASQPGSSVQKARAYDRFSSRPTRDHAPRVQSSNTSTYRFWNDKTKPHLVESLPDVHFDLGEMYSGSINITSHRNESRSLFYIFQPKIGEPSDDLTIYLNGGPGCSSEQAFFQENGRFTWQPGTYAPVINQYSWVNLTNMLWVDQPVGTGYSVGTPTATNEAEVAADFLEFFSKFQDLYGIKNFRIFVSGESYAGRYVPYISSAMLDKNDTTHFNLSGKPAHPLHHLAPTNAVCTGALLYDACIGQWDWVQAELPAYPFVQQHASLFNFNETFMTSLATTYEECGYQAYFDEYFTFPAS...
Serine-type carboxypeptidase; part of the gene cluster that mediates the biosynthesis of aculins (PubMed:26374386). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) acuA via condensation of acetate and malonate units (PubMed:26374386). The 6-methylsalicylic acid decarboxy...
Q3J6K9
MRAVLIEKSDDTQSVSVTELAEDQLPEGDVLVDVAYSTLNYKDALAITGKAPVVRRFPMVPGIDFTGTVAQSSHADFKPGDRVILNGWGVGEKHWGGLAERARVRGDWLVPLPAPLDLRQAAMIGTAGYTAMLCVLALERHGVVPGNGEIVVSGAAGGVGSVATTLLAAKGYEVAAVTGRASEAEYLRGLGAASVIDRNELTGKVRPLGQERWAGGIDVAGSTVLANMLSMMKYRGVVAACGLAAGMDLPASVAPFILRGMTLAGVDSVMCPKTDRLAAWARLASDLDPAKLEEMTTELPFSEVIETAPKFLDGTVRGRI...
Catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. Is essential for growth with 3-hydroxypropanoate as a sole carbon source. Restores acrylate resistance when expressed in the E.coli strain K12 acuI deletion. NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH Homodimer. Moderately induced by ac...
Q2M8W1
MQALLLEQQDGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRTSEDPRFHAGQEVLLTGWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQDGEIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAESRPLEKQVWAGAIDTVGDKVLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFYTQAAKEISLSEAPNFAEAIINNQIQGRTL...
Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH Homodimer. 100-fold increased sensitivity to acrylate, about 8-fold increased sensitivity to 3-hydroxypropionate. Acrylate is bacteriostatic, not bacteriocidal. Can be complemented by ...
Q5LS56
MFNALVVDKDEESGKTQAAVKQLSLTDLPVGEVTVAVEYSTVNYKDGLCIGPGGGLVRKYPHVPGIDFAGTVENSSDERYKPGDKVVLTGWRVGEAHWGGYSQKANVRADWLVPLPEGLDTRQAMAVGTAGFTAMLAVMALEDHGLTPGHGPVLVTGAAGGVGSVATAILAHLGYEVAAVTGRPETADYLTSLGATQIVARDEINETVKRPLESEIWAGCVDAVGGAMLARVLGQMKYGASVAAVGLAGGAGLPATVIPFLLRGVNLLGIDSVMQPYANRLRAWERIARDLPMDKLEAMIRPATLSDLPGLGADILKGQV...
Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. Restores acrylate resistance when expressed in an E.coli strain K12 acuI deletion. NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH Homodimer. By dimethylsulfonioproprionate (DMSP) and acrylate. 25-fold increased sensitivity to acryl...
C0NCM1
MTASTQNGSPTPPPAAPTATNQESKNMTANPADASESQSPANEKGSGTAESGQKHTSTAANAKDPLRPRRKKAKRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPNEALMPGIRRNFYNQANATRTNANQQQNGPNSNSNKDSRQNVAANFYSPQSASNFDVYTQAKSQQGQGHIPPTVMQDTSINPSAFQAPSPTSTPNFDLSSNPPNRNLSSAMTQTPSSASNQTQDPFGAAFFDPSHPALFNFDIASMNFGNRYGALEFGMLGHMATGAGDTPPSDSATQRGSIGRSSGTFTAQNFGDSTNT...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
A6R213
MTASTQNGSPTPPPAAPTATNQESKNMTANPADASESQSPANEKGGGTAENGQKHTSTAANAKDPLRPRRKKAKRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPNEALMPGIRRNFYNQANATRTNASQQQNGPNSNSNKDSRQNVAANFYSPQSASNFDVYTQAKSQQGQGHIPPTVMQDTSINPSAFQAPSPTSTPNFDLSSNPPNRNLSSAMTQTPSSASNQTQDPFGAAFFDPSHPALFNFDIASMNFGNRYGALEFGMLGHMATGAGDTPPSDSATQRGSIGRSSGTFTAQNFGDSTNT...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
C5GF27
MTASTRNGSPSPSPAAPTATEQESKSMTTTPANPPETKSQTNGKGSGTAQSSQKPASTSANAKDPLRPRRKKAKRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPNEALLPGIRGNYYNQANTTRNIPNQRGNASNSNSNKVSRQSVSSANFYTPQAARSYNVYVQAKSQQSHVRPAVMQDASMNPSVFHAQSPSSTQNFDLSSNPQTQNLSSAMSQTASSVSGQNQDPFGAAFFDPSHPALFNFDIASMNFGNRYGALEFGMLGHMATGAGDTPPSDSATQRGSIGRSSGTFTAQNFGDSANNQ...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
D4AL61
MSPHQTTGQESDNMTVNGENAQASSQYIQSNEEMTSAIATEKKASTAKAAKDPSRPKRKKAKRACYACQRGHLTCGDERPCQRCIKRGFQDACHDGVRKKAKYLHDAPNEALMAGVGATLYNQRNAAQNNANGSNTSPGAPQQITSPNFYNTQQSPDYNGFPQNKTELQDSTVGPDNYASQSPVSPTYQISQGLSTQGLSPSLPQSTSETPSAANPAPGQFNSAFFDPSDPALFNFDLASMNFGNHYGALEFGMLGHMATGVGDTPPSESGAQRGSIGQNGSGTFGLTGSNFSESPSNQAPYLFSESGMNDWTQTAPVNR...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
E4UP58
MSPHQTTGQESDNMAVNGENAPASSQYIQTNNDEMADMVAAEKKAAAAKAAKDPSRPKRKKAKRACYACQRGHLTCGDERPCQRCIKRGFQDACHDGVRKKAKYLHDAPNEVLMAGVGATLYNQRNAAQNNVNGSNTSPGVPQQMTSPNFYSTQQSPDYNSFPQNKNELHDSTVGPENYASQSPVSPTYQIGQGMPNPVLSPSLPQSASETPSTANAAPGQFNSAFFDPSDPALFNFDLASMNFGNHYGALEFGMLGHMATGVGDTPPSDSGAQRGSIGQNGSGTFGLAGSNFAESPSNQTPYLFNESGMNDWTQTAPVN...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
C5FP02
MSPHQTTGQESDNMAVNGENAQASSQYIQLNSEETTDTVAAEKKAAAAKAKDPSRPKRKKAKRACYACQRGHLTCGDERPCQRCIKRGFQDACHDGVRKKAKYLHDAPNEALMAGVGASLYNQRNTTQNSINGANAPSSASQQITSPNFYNAQQSPDYNGYSQTKAELQDSTIGPENFASQSPVSPTYQMGQPMPNQGLSPSLPQSASETPSTANGAPSQFNSAFFDPSDPALFNFDLASMNFGNHYGALEFGMLGHMATGVGDTPPSDNGAQRGSIGQNSSGTFGLAGSNFAESPSNQGPYLFGDSGMNDWTQSAPVNR...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
A1C602
MNVEAKESSVAPAGDHGGAVQDPADVRDRLELLKNKANGETNGATPNGTKSTNAKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGVGGNFYNHPMRHNMPLSSNGANAVNATSQQNSGASFYPTPQSNPYNVYQESTLSQNSFPSQSPVSPTFNMKNTATARSNSLSSSVNQPQSNPAASGPPSQSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPSESATQRGSIGRSGSAQFATTPITGNPGFGESPGNQQPFMFGNDPLLNEWP...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
B0XVV1
MKTEVNGSAPALAGDHGGVDQDTPDAGDRTEQAKHKTNGATENAPKSANAKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGVGGNFYNNAMRNNMPLSRNGTTTVNTTTQQNSGSNYYPTPQSNSYNVYQDTPLTQNSFPSQSPVSPTFNMKTTPTARSNSLSSSVNQQPPSTTVSGATQSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPTDSATQRGSIGRSGSTQYSTTPLTGAPGFGESPGNQQPFLFGNDPLLNEWPNSQAP...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
Q4WHD1
MKTEVNGSAPALAGDHGGVDQDTPDAGDRTEQAKHKTNGATENAPKSANAKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGVGGNFYNNAMRNNMPLSRNGTTTVNTTTQQNSGSNYYPTPQSNSYNVYQDTPLTQNSFPSQSPVSPTFNMKTTPTARSNSLSSSVNQQPPSTTVSGATQSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPTDSATQRGSIGRSGSTQYSTTPLTGAPGFGESPGNQQPFLFGNDPLLNEWPNSQAP...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
A2QFG8
MNAEPKEQDSPAPSAERTEASQEISAAGAQADKPKTEANGDGTANGASANGQKPNPKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGIGGTFYNNPMRNSLPLSRNGANAVNATGQQSAGANFYPTPQSTTYVYQENTINQGSFPSQSPVSPTFNLKATPTARTNSLSSVNPQPPSTSVSGPPGQGQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPSDSATQRGSMGRSGSAQYASTPITGAPGFGESPGNQQPFMFGDPLLNEWPS...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
Q2UMM2
MTVDAQDSTPAPPADRRGAELETGGVGEQSEQPKNKSNGDGNAPAETGQKPNPKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPDGALMPGIGGNFYNNTMRSNLPLSRNGANAVNATTQPSSSPNFYPTPQSNSYSVYQENTMNQNSFTSQSPVSPTFTLKANPAARNNSLSSQVNQQPPSTGVSGATNPSQNPFAGPFFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPSDSATQRGSMGRSGSAQFSGTPITGAAAFGESPGGQQPFIFGDPLLNEWSSG...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
Q0CHR0
MKVESRENQPSAASADRSGADQESGAAERPDPSKKTDDGKPHAPAENGQKPPSNAKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACTDGVRKKAKYLHDAPDGALMPGVGGNFYSSNNNNSSMRNNLPLSRNGANAVNANAQQNTGANFYPTPQSTSYNVYQENPINQSSFTSQSPVSPTFNLKTNPTARTNSLSSVGQQPPTTTGVSGPNPQNPFAGALFDPSDPALFNFDLSSMNFENRYGALEFGMLGHMATGAGDSPSDSATQRGSMGRSGSAQFSNTPITGQPGFGESPGGQQPFMFGDPLLN...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
A0A179URQ2
MTASTRNGSPSPSPAAPTAAEQESKSMTTTPANPPETKSQTNGKGSGTAQSSQKPASTSANAKDPLRPRRKKAKRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPNEALLPGIRGNYYNQANTTRNIPNQRGNASNSNSNKVSRQSVSSANFYTPQAARSYNVYVQAKSQQSHVRPAVMQDASMNPSVFHAQSPSSTQNFDLSSNPQTQNLSSAMSQTASSVSGQNQDPFGAAFFDPSHPALFNFDIASMNFGNRYGALEFGMLGHMATGAGDTPPSDSATQRGSIGRSSGTFTAQNFGDSANNQ...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
A6SP81
MSGETEIDDPEVSDGASENDYSDHEQELDVIGKEGDNQEMAEQKVRPDGEENGNTVGATATVTKPKFDPKDPLRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLADACQDGVRKKAKYLHDAPPEALRPVLGPTYNQQVSSNRATAASTPTEPSPGMGNFFSQPDTSPSYPLFGANQQGQMPPPLQNRLSFGSNQPSPISPTFHTAGNRPAGMQGISLPQVSNDSHSAFGGGAFFDPSNPALFNFDLEGLNFGNHYGALEFGMLGHMASGSAETPPQDSSAGMPQNVGDLGFSNNSAFTNNPPFNQIYSHDSLPDF...
Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family.
Q83AB0
MTQKEKNETCIHVTVSGKVQGVFFRESVRKKAEELQLTGWVKNLSHGDVELVACGERDSIMILTEWLWEGPPQAAVSNVNWEEIVVEDYSDFRVR
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
A7ME43
MAWVHGRVQGVGFRYTTQHEATRLGLTGYARNLDDGSVEVLACGEAEQVEKLIAWLKAGGPRSAHVEKVLTEPHSPTEDYQDFRIRY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q1LIH0
MTTTTETWQLFAHGRVQGVGYRAACADRATSLGLGGWVRNRVDGRVEVLASGPRERLEALRVWMEAGPPAAQVSKVEVAQAAPQLFDRFDWLPTA
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q0K6H7
MKKETWRLVAHGRVQGVGYRAACADAADDLELGGWVRNRLDGTVEVMAHGTVRQLEALQAWMEQGPPAAQVTLVEVGPGEGEFAGFEFRPTI
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q46WU4
METWHMTAHGRVQGVGYRAGCAQAAIALGVRGWVRNRADGTVEVMASGTIQQLEALRNWMQAGPPAAHVARVDVEPGQGKFEDFDLRPTL
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q47GU0
MARIRRQLIIEGRVQGVGYRWSMAEQARKLGVVGWVRNLADGRVEAMAVGEEMAVLELIAWARRGPSHAIVRQVSVALGDGDFPSFEQRANG
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q3Z7Q6
MHCLKAVVKGKVQGVYFRDFTRTQAIRLGLCGYAQNLESGTDVEVIAEGDKDILLEFLKLLRSGPPHAEVQEVEVSWSSTNGNYGDFHIKY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
A5FQM9
MHCLRAIVKGKVQGVYFRDFTRTQATRLGLCGYAKNLANGAEVEVVAEGDKDALLEFLNLLRSGPPRAEVKDVETGWETATANYSDFRIKH
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q3ZXY7
MHCLRAIVKGKVQGVYFRDFTRTQATRLGLCGYAKNLANGAEVEVVAEGDKDALLEFLDLLRSGPPRAEVKDVETSWETATANYSDFRIKH
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q1J123
MRLTALVSGTVQGVGYRRYVQRHARDLGLSGSAENLPDGRVEVVAEGPPEHLERLLHWLRRGPPHARVADVQTQYSEATGLRDFHVY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q9RVU3
MRLTALVSGHVQGVGYRLFVQRYARDLGLHGYAENLSDGKVEVIAEGDEDALNRLLHWLRRGPPHARVQAVDTQYSEETGLREFHIY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q72CU1
MPRRSYSVIGRVQGVGFRSWTRRTALRLDLRGWVRNEPDGTVRLCADGTDEALATLETALRKGPMFSRVDHVVKHDDPAHEGPLPDTFDIRFRAPGSASE
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
A1VEL6
MPRRSYSVIGRVQGVGFRSWTRRTALRLDLRGWVRNEPDGTVRLCADGTDEALATLETALRKGPMFSRVDHVVKHDDPAHEGPLPDTFDIRFRAPGSASE
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q9R7Q1
MSKVCIIAWVYGRVQGVGFRYTTQYEAKRLGLTGYAKNLDDGSVEVVACGEEGQVEKLMQWLKSGGPRSARVERVLSEPHHPSGELTDFRIR
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Optimum pH is 5.2-6.5. Thermostable. Retains 85-90 % of its activity after 3 hours of incubation at 90 degrees Celsius. Has a considerably reduced catalytic efficiency compared to other mesophilic acylphosphatases. Shows a considerable resistance against urea d...
A1A9N7
MSKVCIIAWIYGRVQGVGFRYTTQYEAKKLGLTGYAKNLDDGSVEVVACGDEGQVEKLIQWLKSGGPRSARVERVLSEPHHPSGELTDFRIR
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q8FJ70
MSKVCIIAWVYGRVQGVGFRYTTQYEAKKLGLTGYAKNLDDGSVEVVACGDEGQVEKLMQWLKSGGPRSARVERVLSEPHHPSGELTDFRIR
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
A4W8Y0
MMSKVCTIAWVHGTVQGVGFRYSTQREALQLGLTGYARNLDDGSVEVVACGEADNIEQLIAWLKAGGPRSARVEKVFTEPHQPDREYDKFSIRY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q831U6
MEKLRMNVQGRVQGVGFRYMTKMVADQLGVTGSVRNEDDGSVSITAIAPEDIMETFIKKIKDSPSPAGRVTYVDIQEDPLLEETEQFKVIQ
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
A7HMJ7
MLEVWKKWNVRGVVQGVGFRHFVKNVARAIGVRGYVKNEDDGSVTIVAGGNDEQIKELFRRIMEGNGWSYISDYDEIDLPKQEYKDFHVEF
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q0IBG0
MKERWRFLIEGSVQGVGFRNSCRRRALDLGLCGWVRNLKDGVVEIQAEGDELALNELRLWCERGPSAATVKRVLLSKIPVTGNDWFDVRT
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q3AYW4
MARRTRNRSEIIARRFVSRQQPTRTQPFVERWRWIIQGQVQGVGFRASCSRRALDMGLKGWVRNLQDGSVEVQAEGPPIALAELRAWCEKGPLGAQVKRVKPCQMPVRGDDWFEVRY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q3AIC0
MIEGRVQRVGFRASCNRRALDLGISGWVRNLSDGRVEVQAEGPPLALSELRAWCEVGPPGARVVRVTPSQLPITGDDWFEVRY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q47S76
MEKVRLTAWVRGHVQGVGFRWWTRARALELGLTGAATNLDDGRVEVVAEGDRTACERLLELLRSGQTPGRVDSVVERWTNHRGSFTGFEER
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q5JDG7
MKRVRAHLRIYGRVQGVGFRWSMSREARKLGVHGWVRNLPDGTVEAVIEGDPERVEALIGWAHQGPPLARVTRVEVKWEEPEGLEGFKVVG
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q9X1Q0
MKALKIRVEGIVQGVGFRYFTRRVAKSLGVKGYVMNMDDGSVFIHAEGDENALRRFLNEVAKGPPAAVVTNVSVEETTPEGYEDFTIKYY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
A5IM19
MKALKIRVEGIVQGVGFRYFTRRVAKSLGVKGYVMNMDDGSVFIHAEGDENALRRFLNEVAKGPPAAVVTNVSVEETTPEGYEDFTIKYY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
A1RZ22
MRAHIYVSGLVQGVFFRASMQEVARSLGVNGWVRNLPDGRVEAVLEGEEGAVLKVIEWARRGPPLARVERVDVEWEEYRGEFRDFYIKYR
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q72L64
MPRLVALVKGRVQGVGYRAFAQKKALELGLSGYAENLPDGRVEVVAEGPKEALELFLHHLKQGPRLARVEAVEVQWGEEAGLKGFHVY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q5SKS6
MPRLVALVKGRVQGVGYRAFAQKKALELGLSGYAENLPDGRVEVVAEGPKEALELFLHHLKQGPRLARVEAVEVQWGEEAGLKGFHVY
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q97CT1
MLTTRRVRFYGRVQGINFRSNTLVKALELGVKGWIKNLPDGSVEALFSGESEQIEKLISYCVSNMPYAEVKRYDVYIEPYTEFQDFQIKR
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q3SKG9
MKTLHLQIEGRVQGVWFRESMRREAERLGVDGWVRNRPDGSVEAVVQGTDEAVAALVAWAKMGPPLAHVERVDLSETEGEYSGFEKRSD
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q73PK2
MDKETLRALHVIVKGRVQGVGFRYWTRSLAKSLNVKGRVRNLADYSVEIIAEADTDTLGEFVYALKHEHPYARVESLNSEEVRARGYTDFRIEV
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q3M4K7
MPNSTPQSQLIRVHVFVTGRVQGVGFRYSTVDTASQLGLTGWVRNLPDGRVEAVFEGARDIVEEMVRWCHAGPPAAVVQDVAVEYEEPEGLRGFEVKRLVN
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
C3M0B6
MEKQCSKFIVSGHVQGVGFCYHTSHQGLKLGLTGYAKNLNNGDVEVVACGTPERLEELYLWLQEGPKTASVRQVRRLSSELEHDYQGFEIL
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family. Lacks the conserved active site Arg in position 20. There is a cysteine in this position.
Q9KSA4
MEKQCSKFIVSGHVQGVGFRYHTSHQGLKLGLTGYAKNLNNGDVEVVACGTPERLEELYLWLQEGPKTASVRQVRRLSSELEHDYQGFEIL
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q87P91
MNVKCERFIVKGHVQGVGFRYHTSHQGLKLGLTGYAKNLNNGDVEVMACGPKEKIDQFCEWLQEGPRTATVESVTRESVSYKPFRGFKIL
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q8D994
MAIRCEKFVVSGIVQGVGFRYHTSHQGLKLNLVGYAKNLYNGDVEVIACGEPLKIEEFAKWLEQGPKTARVDELKREEITCREYQGFEIL
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q7ML77
MAIRCEKFVVSGIVQGVGFRYHTSHQGLKLNLVGYAKNLYNGDVEVIACGEPPKIEEFAKWLEQGPKTARVDELKREEITCREYQGFEIL
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
Q8PNV0
MQAARFVVSGVVQGVYYRACTRQRAVALGLVGHARNQADGSVDVVAAGSAAALDALEAWLCRARRPPRSRRSRARPARFRRLKTL
an acyl phosphate + H2O = a carboxylate + H(+) + phosphate Belongs to the acylphosphatase family.
P19219
MPDSINNGHKESHDHRISNDAEMITDEKWQAIINNDAAYNNQFFYAVKSTGIFCKPSCKSRVPKKENVCIFPNTEQALRANFRPCKRCKPTNEKMPDSEWVDLITEYIDKNFTEKLTLESLADICHGSPYHMHRTFKKIKGITLVEYIQQVRVHAAKKYLIQTNKAIGDIAICVGIANAPYFITLFKKKTGQTPARFRQMSKMEETYNGNK
Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the methylphosphotriester lesions in DNA by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. The methylation of AdaA by methylphosphotriesters in DNA leads to its activation a...
A2QX23
MAFRIPFAQSFWQEYLSGQEANLPRLPEVEQVTETVMRILGGNPGRMQLQGTNTYLVGTGKFRILIDTGQGEASWIEALTKQLEANGLEISHVLLTHWHGDHTGGVPDLITYNPELSSRVYKNTPDLGQQAIHDGQKFHVEGATIRAVFTPGHAFDHMCFLLEEENALFTGDNVLGHGYSVVEDLGTYMTSLTRMADLNCALGYPAHGTRIEDLPAKMKEYIQHKESRMRQVLAALERSRARMTATGGGRRAGALTFPELINSMYGGIPDEIEQALTPFLSQVLWKLAEDRKVGFEGEPSQRRWFAVGPPAATAVRL
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960). The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit with 9 ...
G3KLH5
MAFRIPFAQSFWQEYLSGQEANLPRLPEVEQVTETVMRILGGNPGRMQLQGTNTYLVGTGKFRILIDTGQGEASWIEALTKQLEANGLEISHVLLTHWHGDHTGGVPDLITYNPELSSRVYKNTPDLGQQAIHDGQKFHVEGATIRAVFTPGHAFDHMCFLLEEENALFTGDNVLGHGYSVVEDLGTYMTSLTRMADLNCALGYPAHGTRIEDLPAKMKEYIQHKESRMRQVLAALERSRARMTATGGGRRAGALTFPELINSMYGGIPDEIEQALTPFLSQVLWKLAEDRKVGFEGEPSQRRWFAVGPPAATAVRL
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960). The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit with 9 ...
P19220
METNKPTLYWSLLMFKDWNFYIASTLKGLVFVGSQNKPIEELFEWARKRFPGSLLVEDDDKLEPYAVEITQYLEGKRKNFTVPVEYAGTQFQLAVWNALCEIPYGQTKSYSDIANDINKPAAVRAVGAAIGANPVLITVPCHRVIGKNGSLTGYRGGFEMKTLLLDLEKRASSEMDVPH
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inac...
A2QX24
MTPPILIIGAGLSGLTVSRILTNASIPNIVFEASTPDRSQGYAISLRDWGYTSLLTALGDLPLRSLTRGVAPDRILGGTGWIDQALRDNHTGNLLVAPDPEAKQCIVRANRNALRTWIADSGDEEVDIRYGHRLRSVQGSMGNVTATFENGAKYQGSLVIAADGVHSSVRSQILPHVSPDIVPVVVYHGELELPRKEFDNLIRPHSGPSNILAGVGDGFNTPITVCNITPTHVHLDWSYSRPSTENKENKDPLYRPHVSAAEAKQIPPALLEEIASRDLARPWSQLLNAEALPTHRVFNWVSRCVSVTREDVNAAQKQGV...
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960). The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit wi...
G3KLH4
MTPPILIIGAGLSGLTISRILTNASIPNIVFEASTPDRSQGYAISLREWGYTSLLTALGDLPLRSLTRGVAPDRILGGTGWIDQALRDNHTGNLLVAPDPEAKQCIVRANRNALRTWIADSGDEEVDIRYGHRLRSVQGSMGNVTATFDNGAKYQGSLVIAADGVHSSVRSQILPHVSPDIVPVVVYHGELELPRKEFDNLIRPHSGPSNILAGVGDGFNTPITVCNITPTHVHLDWSYSRPSTENKENKDPLYRPHVSAAEAKQIPPALLEEIASRDLARPWSQLLNAEALPTHRVFNWVSRCVSVTREDVNAAQKQGV...
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960). The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit wi...
P0DTR4
MRNRRKAVSLLTGLLVTAQLFPTAALAADSSESALNKAPGYQDFPAYYSDSAHADDQVTHPDVVVLEEPWNGYRYWAVYTPNVMRISIYENPSIVASSDGVHWVEPEGLSNPIEPQPPSTRYHNCDADMVYNAEYDAMMAYWNWADDQGGGVGAEVRLRISYDGVHWGVPVTYDEMTRVWSKPTSDAERQVADGEDDFITAIASPDRYDMLSPTIVYDDFRDVFILWANNTGDVGYQNGQANFVEMRYSDDGITWGEPVRVNGFLGLDENGQQLAPWHQDVQYVPDLKEFVCISQCFAGRNPDGSVLHLTTSKDGVNWEQ...
One of an enzyme pair that work together to convert the A antigen to the H antigen of the O blood type, which together release galactosamine. Catalyzes the first step in the conversion, generating the substrate for the subsequent enzyme (FpGalNase, AC P0DTR5). Works on many different A antigen subtypes. Glu-90 probably...
Q8NA06
MASNNHWFQSSQVPSFAQMLKKNLPVQPATKTITTPTGWSSESYGLSKMASKVTQVTGNFPEPLLSKNLSSISNPVLPPKKIPKEFIMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRILETSGPPPFPAEPVVLSELAYVSKVHYEGRHIQYAKISQIVKERFNQLISNRSEYLKYSSSLAAFIIERAGQHEVVAIGTGEYNYSQDIKPDGRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMMEKSIFCTEPTSNLLTLKQNI...
Required for male fertility and normal male germ cell differentiation (By similarity). Plays a role in spermatogenesis (By similarity). Binds to RNA but not to DNA (By similarity). Belongs to the ADAD family.
Q9JLB6
MATAGGSRRAPVPGPRLGLPLAAHLPASLGGEGAKDSVGGEKTSGNNDWFQSSRVPSFAQMLKKNLPVQPSAQTVTLPTGYSSESCSLSNMASKVTQVTGNFPEPLLSKGLSSISNPVLPPKKLPKEFIMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRVLEPAGPPPIPAEPVVTPEAAYVSKVQYEGRQVQYAKISQLVKETFGQLISNHSQYLKCSSSLAAFIIERAGHHEVVAIGTGEYNYSQCIKPNGRVLHDTHAVVTAR...
Required for male fertility and normal male germ cell differentiation (PubMed:32665638). Plays a role in spermatogenesis (PubMed:15649457). Binds to RNA but not to DNA (PubMed:15649457). Testis-specific. Detected in round spermatid cells from stage II-XI (at protein level). Expressed in germ cells from mid-pachytene sp...
Q3KR54
MATAGGSRRAPVPGPRLGLPLAAHLPASLGGEGAKDSLGGEKTSGNNDWFQSSRVPSFAQMLKKNLPVQSSAQTVTLPTGYSSESCSLSNMASKVTQVTGNFPEPLLSKGLSSISNPVLPPKKIPKEFIMKYRRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRALEPAGPPPIPAEPIVTPEAAYISKVQYEGRQVQYAKISQLVKETFSQLISSHSQYLKCSSSLAAFIIERGGHHEVVAIGTGEYNYSQCIKPNGRVLHDTHAVVTAR...
Required for male fertility and normal male germ cell differentiation (By similarity). Plays a role in spermatogenesis (By similarity). Binds to RNA but not to DNA (By similarity). Belongs to the ADAD family.
Q32NG0
MASNRNWSQHSSVPSFAQMLKKNLPDPGTSPAVNQTSTLSTCCLYNQPDCGTARVTRITGNFPEPFLSKMIVPPSLSSLTPRKVTKEFMVKYRRGDLNPISALYQFAQMQRMEIELKETVTTGNVFGAYFAFCAVVDGLEYKTGMGQNKKEAKANAAKLALDELLLHEDPALIDSENQSLNVIENPPPLPMNPRGTTETSTISRTRTDKRTFIHEKISSIIKETFTNLVSKYPEYENCGSSLAAFVIEKGGQHWEVVAIGTGEFNYGQSLQSDGRVLHDSHAMVVARRSLLRYFYRQLLLLYSGNNGMMDKSIFCTEPAT...
May be required for male fertility and normal male germ cell differentiation (By similarity). May play a role in spermatogenesis. Binds to RNA but not to DNA (By similarity). Belongs to the ADAD family.
Q8NA94
MASASQGADDDGSRRKPRLAASLQISPQPRPWRPLPAQAQSAWGPAPAPATYRAEGGWPQVSVLRDSGPGAGAGVGELGAARAWENLGEQMGKAPRVPVPPAGLSLPLKDPPASQAVSLLTEYAASLGIFLLFREDQPPGPCFPFSVSAELDGVVCPAGTANSKTEAKQQAALSALCYIRSQLENPESPQTSSRPPLAPLSVENILTHEQRCAALVSAGFDLLLDERSPYWACKGTVAGVILEREIPRARGHVKEIYKLVALGTGSSCCAGWLEFSGQQLHDCHGLVIARRALLRFLFRQLLLATQGGPKGKEQSVLAPQ...
Required for male fertility and normal male germ cell differentiation. Diffusely cytoplasmic early in pachytene spermatocytes and coalesces into several perinuclear granules by late pachynema. Belongs to the ADAD family.
Q95JT2
MASASQGADDGSRRKPRLAASLQISPEPRPWRPLPPQAQGAWEPAPAMDHAEGGQPQVSVLRDSGPGAGAGVGELGAAQAWENLGEQMGRTPRVPVPPAGLSLPLKDPPASQAVSLLTEYAASLGIILLFREDQQPGPCFPFSVSAELDGVVCPAGTANSKTEAKQQAALSALCYIRSQLESPESPQTSSRPPPPPLSVDSILTHGQRCAALVSAGFDLLLDERSPYWACKGTVAGVILEREIPGARGHVKEIYKLVALGTGSSCCAGWLEFSGQQLHDCHGLVIARRALLRFLFRQLLLATQGGAKGKEQSVLAPQPGP...
Required for male fertility and normal male germ cell differentiation. Diffusely cytoplasmic early in pachytene spermatocytes and coalesces into several perinuclear granules by late pachynema. Belongs to the ADAD family.
B2RQL4
MASVDEGGRRRPRLAASLQISPGPWKPSGGQEPTEAGDAAPRTAEHGVAGAQEAHREACKALGGSVLSPGPAGDFPGALHGLSMLPKDPPPAQAVALLTQCMANLGVSLTFLEDQTAGPGSSFSVCADLDGLVCPAGTGSSKLEAKQQAALSALQYIQKQLERPEPLVTPRQPLLTSLSIETILTHEQRCAAVVSAGLDRLLSESSPYQACKGTVAAVILEREVQGSIGHSKETYELVALGTGSSSCAGWLEFSGRRLHDCHGLVIARRALLRFFFRQLLLVTQGGPKGQERSVLTPQPGPGPPFALKPGVFLHLYVSNT...
Required for male fertility and normal male germ cell differentiation. Diffusely cytoplasmic early in pachytene spermatocytes and coalesces into several perinuclear granules by late pachynema. Testis-specific (at protein level). Male mice are sterile and show defects in germ-cell development. Belongs to the ADAD family...
A2QX25
MSSVTLTTTTTTTSTPPKPTPKDEPQEQIYTPWRLFIYDIWVLGIVSTLAWGCRISTYLIPLFRSNVGKKHLDIGAGTGYYLNQARIPSTTQLTIVDNETHALNVALARCKHPSTQTHGIVTDILQPSPFPETYLTNNDKKFDSVSMYYLLHCLPVPVASKCKIFTHLKKYMTEDGVVHGANVLGKGVRKDNWFARIIRRGCLNHGVFHNEEDNAYEFERALRENFWEVETWVVGSVFVFRAKRPILDA
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960). The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit with 9 mal...
G3KLH3
MSSVTLTTTTTTTSTPPKPTPKDEPQEQIYTPWRLFIYDIWVLGIVSTLAWGCRISTYLIPLFRSNVGKKHLDIGAGTGYYLNQARISSTTQLTIVDNETHALNVALARCKHPVTQTHGIVTDILQPSPFPETYLTNNDQKFDSVSMYYLLHCLPVPVASKCKIFTHLKKYMTEDGVVHGANVLGKGVRKDNWFARIIRRGCLNHGVFHNEEDNAYEFERALRENFWEVETWVVGSVFVFRAKRPILDA
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist (PubMed:21866960). The decaketide backbone of TAN-1612 is synthesized by the non-reducing polyketide synthase adaA via condensation of one acetyl-CoA starter unit with 9 mal...
Q6GN35
MAGEGALQFYRDLPKVELHAHLNGSISTATMKKLMARKPHLDIQHGMTMIDKGQKRTLEECFQMFKIIHQITDTAEDILLVTKDVIKEFAADGVKYLELRSTPRDTPAGLTKQAYVETVLEGIKQCKEEGVDIDVRFLLAIDRRGGPTAAKETVKLAEDFFCSSNELVLGLDLSGDPTVGHGRDFMEPLNKARQSGLKLALHLSEIPSQTEETELLLGLPPDRIGHGTFLTTSAHIVEIVKKQHIPLELCITSNIKGQTVSSYNEHHFGFWYNLHHPFVLCTDDKGVFATDLSVEYEIAAKTFNLTPHHVWDLSYQAIDY...
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). H(+) + H2O + N(6)-m...
Q9M0Z1
MEWIQSLPKIELHAHLNGSIRDSTLLELARVLGEKGVIVFADVEHVIQKNDRSLVEVFKLFDLIHKLTTDHKTVTRITREVVEDFALENVVYLELRTTPKRSDSIGMSKRSYMEAVIQGLRSVSEVDIDFVTASDSQKLHNAGDGIGRKKIYVRLLLSIDRRETTESAMETVKLALEMRDVGVVGIDLSGNPLVGEWSTFLPALQYAKDNDLHITLHCGEVPNPKEIQAMLDFKPHRIGHACFFKDEDWTKLKSFRIPVEICLTSNIVTKSISSIDIHHFADLYNAKHPLILCTDDFGVFSTSLSNEYALAVRSLGLSKS...
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:29884623, PubMed:30721978, PubMed:31318636). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA contain...
Q0VC13
MMEAEEQPWKTTFYSKLPKVELHAHLNGSISSNTIRKLIAKKPDLKIHDQMTMIDKGEKRTLEECLQMFQIIHLLTTTPEDVLMVTKDVIKEFADDGVKYLELRSTPRGEDATGMTKKTYVESILEGIKQSKEENVDIDVRYLISIDRRGGSSAAKEAVKLAEEFFLSAEDTVLGLDLSGDPSAGQAKDFLEPLLEAKKSGLKLALHLSEIPNQKTETQVLLNLFPDRIGHGTFLSSSEEGSPDLVDFVRQHQIPLELCLTSNVKSQTVPAYDQHHFGFWYSVAHPAVICTDDKGVFATRLSQEYQLVAETFHLTQSQVW...
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). H(+) + H2O + N(6)-m...
Q8IG39
MPNNSKHKKKQQRRQQEAQKKSRAKQIETDKKNDEFLDTELDEVSPLVIDDDMTEFKNMPKVELHAHLSGSLSPETIKLIMESDETRAEEIMKKYKLEKPENMTGVFDCFPVIHAILRKPEAIRIAIRQTIKEFEEDNCVYLELRTSPKETDFMTYEDYLQVCIESFEAAKHEFPRIKTFLIVSLDRRMPFETAAHILGLIGEAQQRTNVIVGVELSGDPHLDGRRLLKLFVAARRFHGLGITIHLAEVLQNMADVEDYLNLRPDRIGHGTFLHTDPYTEYLTNKYKIPLEICLSSNVYSKTTTNYRNSHFNYWRKRGVP...
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). H(+) + H2O + N(6)-m...
Q8NFM3
MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLP...
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the re...
Q5BL06
MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGAVTPQQQQRLASRWRGGDDDEDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDGGRGSRRQRRGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVELGLEERRGKGRAAEELEPGTGIVEDGDGSEDGGSSVASGSGTGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLL...
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion. ATP = 3',5'-cyclic AMP...
P40144
MSGSKGVSPPGYAAQTAAAPASRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQQQQRLASRWRGDDDDEPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAAGGGSTRAPPAGGGCGGGSAAAAAAAGGTEVRPRSVELGLEERRGKGRAVDELEAGAVEGGEGAEDGGSSADSSNGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGL...
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion. ATP = 3',5'-cyclic AMP...
Q04400
MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGAVTPQQQQRLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDGGRGSRRQRRGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVEVGLEERRGKGRAAEELEPGTGTVEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLL...
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:1409703). Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion. ATP =...
P30804
MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRTSGFCTPRYMSCLRDAQPPSPTPAAPPRCPWQDEAFIRRGGPGKGTELGLRAVALGFEDTEAMSAVGAAGGGPDVTPGSRRSCWRRLAQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAATLFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPRSPSVGLWCPVFFVYITYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQLGANMLLFLCTNVIGICTHYPAEVSQRQAFQETR...
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:1528892, PubMed:17110384). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and pla...
Q9UDB0
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQE...
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of t...
Q01341
MSWFSGLLVPKVDERKTAWGERNGQKRPRHANRASGFCAPRYMSCLKNAEPPSPTPAAHTRCPWQDEAFIRRAGPGRGVELGLRSVALGFDDTEVTTPMGTAEVAPDTSPRSGPSCWHRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLTFHAAPAQPQPAYVALLTCASVLFVVLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPHSPSAGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWQLNSSDPFLWKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETR...
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:18071070, PubMed:24363043). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:18071070). Functions in signaling cascades downstream of t...
Q03343
MSWFSGLLVPKVDERKTAWGERNGQKRPRQATRARGFCAPRYMSCLKNVEPPSPTPAARTRCPWQDEAFIRRAGPGRGVKLGLRSVALGFDDTEVTTPMGTAEVAPDTSPRSGPSCWHRLAQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLTFHAAPALPQPAYVALLTCASVLFVVLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPRSPSAGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWHLNNGDPFLWKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETR...
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:1409703, PubMed:15385642, PubMed:17110384, PubMed:21606183). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:21606183). Functions in s...
O02856
MPAKGRYFLNEGEEGPDQDALYEKYRLTSQHGPLLLMLLLVAIAACTTLIVITFSYGDPSRHRAVLGTAFFTLAMFVLLYALVYVECLDRRGLRISALLIWGCLVTLGYVLVFDFDSPRKDTLCLWGRCPSSSFVVFVVYTLLPFSMWGAVTAGLVSSISHLLVLAMHQEDFTSPVGLKLLATAVVFVCGNLTGAFHKHHMQDASHDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKERGDRRYLPDNNFHNLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANEC...
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (By similarity). Also, dur...
A0AVA6
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANEC...
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:2322950...
Q3U3P2
MPAKGRYFLNEGDEGPDQAALYEKYRLTSLHGPLLLLLLLVAAATCIALISIAFSHEDLRRHQVVLGTAFLMLTLFVALYVLVYVECLVQRWLRALALLTWACLMVLGSVLMWDSLENEAHAWEQVPFFLFVVFVVYALLPLSRRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKAN...
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:1854153...
P40145
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQ...
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by...
G3X8V9
MELSDVHCLSGSEELYTIQPTPPAGDDGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGGGVSRKASNPAGSGPNHHAPQLSSDSVLPLYSLGPGERAHNTGGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDNTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAVFSINQVL...
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion (PubMed:10864938, PubMed:25403481, PubMed:10482244, PubMed:14585998, PubMed:18448650). Plays a role in many brain functions, such as learning, memor...
P40146
MELSDVHCLSGSEELYTIHPTPPAADGGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGGGSRKASNPAGSGPNHHAPQLSSDSVLPLYSLGSGERAHNTGGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAVFSINQVLA...
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion (PubMed:8163524, PubMed:24086669, PubMed:22494970, PubMed:21046358, PubMed:13680124, PubMed:25381556). Plays a role in many brain functions, such as...
Q9DGG6
MASPPHQQLLHHHSTEVSCDSSGDSNSVTVRINPRQQQALSAKRCKYSISSSCSSGESGGVGRGGGGGLRRQKKLPQLFERASSRWWDPKFDSTNLEEASMERCFPQTQRRFRYALFYIGSACLLWGIYFGVHMREKQMVFMVPALCFLLVCVAFFAFTFTKAYARRYVWTSGYTLLVFALTLAPQFQPWTLGERQRVQPRPAAPVDTCLSQVGSFSMCVEVLLLLYTVMHLPLYLSLFLGLSYSVLFETSAFRDESCTLLGGGAVYWELLSKAFLHVCIHAIGIHLFIMSEVRSRSTFLKVGQSIMHGKDLEVEKALKE...
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. ATP = 3',5'-cyclic AMP + diphosphate Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimula...
Q9UGP2
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHG...
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrener...
Q61279
MASSPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNTHPKHCKYSISSSCSSSGDSGGLPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSMNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMKSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVWTPLSGRVDSSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFETFGYHFRNEDCYPSPGPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHG...
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and by beta-adrenergic receptors. ATP = 3',5'-cyclic AMP + diphosphate Binds 2 magne...
P98999
MASPVNQQLLHHTEVRCDGSGDGSSVTVRINRQHHQAPSRRCKYSISSSCSSGESGVKKTGGSGGARRQKKLPQLFERSTSNWWNPKFDSNNLEEACVERCFPQTQRRFRYALMYLSVAGLLWSIYFSVHMKTKLVSHLVPTLCFLIVCLGFFFFTFTKSYARHCTAISLLVTLLVFTLTLASQFQVLNPGLGSDSLSNLTSFSATGSSSCLSQVGSFSICVEVLLLLYTVMHLPLYLSACLGVAYSILFETFGYHFRDESCFVLLVGRMAHWELLSKALLHVCIHAIGVHLFIMSEVRSRSTFLKVGQSIMHGKDLEVE...
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. ATP = 3',5'-cyclic AMP + diphosphate Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). Detected in oocytes. The protein contains two modules with six transme...
Q9NNX0
MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMH...
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatoge...
Q3V0F8
MSARRQELQDRAIVKIAAHLPDLIVYGDFSPERPSVKCFDGVLMFVDISGFTAMTEKFSTAMYMDRGAEQLVEILNYYISAIVEKVLIFGGDILKFAGDALLALWKVERKQLKNIITVVIKCSLEIHGLFEAKEAEEGLDIRVKIGLAAGHITMLVFGDETRNYFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVSFLKPPPTFNFDEFFTKCMGFMDYYPSGDHKNFLRLACMLESDPELELSLQKYVMEIILKQIDDKQLRGYLSELRPVTIVFVNLMFKEQDKVEVIGSAIQAACVH...
Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm matur...
A2RFA9
MKLIYTEMSYSMTEILVNEARKAADQGYRVFYIAPNSLSFEKEREVLTLLPERGTFSIIVTRFVQMSRYFTVESSPSKQHLDDTTLAMIFYRALMQLKPEDLPSYGRLQNNSVFIEQLVELYKELKNAQLSVHDLTGLDHPQKQEDLIKIIELAETIMIQQDYNQDSPLQSFARAIKLGLLNNQLSKTVVVIDGFSRFSAEEDYLLSLLNNNCQEVIIGSYVSQKAYQKSFIKGNIYEASLHFLQDLAQKYHIKPVFATSNQVFKPAFSRLTQLFEATHDFSQVDWQLQKNDLDHFSLWQCHHQKEEIEHVAKSIRQKLY...
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodi...
B1IBR5
MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLEYLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLH...
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodi...
B8ZQ31
MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLECLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQITLVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLH...
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. ATP + H2O = ADP + H(+) + phosphate Heterodi...