clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
C=CC(C)(C)C(=O)NCC1C2CN(C(=O)c3sc(NCC)nc3C)CC12
CP002676884441
-23.53
O=C(c1cncs1)N1CC2CC2C1
CSC=CC(=O)NCC1C2CN(C(=O)c3sc(C(C)(C)C)nc3C)CC12
CP002677593992
-23.52
O=C(c1cncs1)N1CC2CC2C1
CCC=CC=CC(=O)NCC1C2CN(C(=O)c3cnc(C(F)(F)F)s3)CC12
CP001995342906
-23.26
O=C(c1cncs1)N1CC2CC2C1
CC(C)CCOCC(=O)NCC1C2CN(C(=O)c3cncs3)CC12
CP003417748175
-22.92
O=C(c1cncs1)N1CC2CC2C1
CCc1nc(N)sc1C(=O)N1CC2C(CNC(=O)C(C)(C)C(F)F)C2C1
CP002676962145
-22.79
O=C(c1cncs1)N1CC2CC2C1
CCCCSCC(=O)NCC1C2CN(C(=O)c3cnc(COC)s3)CC12
CP002677139174
-22.57
O=C(c1cncs1)N1CC2CC2C1
CC(O)CCCC(=O)NCC1C2CN(C(=O)c3cnc(C(C)C)s3)CC12
CP002677571176
-22.01
O=C(c1cncs1)N1CC2CC2C1
CCOC(C(=O)NCC1C2CN(C(=O)c3cnc(C(C)C)s3)CC12)C(C)C
CP001993855961
-21.94
O=C(c1cncs1)N1CC2CC2C1
COc1nc(Cl)c(C(=O)N2CC3C(CNC(=O)C(C)(C)C(C)C)C3C2)s1
CP002676773299
-21.52
O=C(c1cncs1)N1CC2CC2C1
CCC(F)C(=O)NCC1C2CN(C(=O)c3sc(C(C)C)nc3C)CC12
CP003059548298
-21.44
O=C(c1cncs1)N1CC2CC2C1
CCC(C)C(OC)C(=O)NCC1C2CN(C(=O)c3cnc(C(C)C)s3)CC12
CP001993962231
-20.97
O=C(c1cncs1)N1CC2CC2C1
CCNc1nc(C)c(C(=O)N2CC3C(CNC(=O)CC(O)CC)C3C2)s1
CP002677220533
-20.93
O=C(c1cncs1)N1CC2CC2C1
Cc1nc(CO)sc1C(=O)N1CC2C(CNC(=O)CCF)C2C1
CP003496156913
-20.74
O=C(c1cncs1)N1CC2CC2C1
COCCCCC(=O)NCC1C2CN(C(=O)c3cnc(CC(C)C)s3)CC12
CP001993292165
-20.7
O=C(c1cncs1)N1CC2CC2C1
CC(O)CCCC(=O)NCC1C2CN(C(=O)c3cncs3)CC12
CP003496159414
-20.69
O=C(c1cncs1)N1CC2CC2C1
CC(C)NC(=O)C(=O)NCC1C2CN(C(=O)c3scnc3C(C)(C)C)CC12
CP001995261795
-20.61
O=C(c1cncs1)N1CC2CC2C1
C=CCC(C)(C)C(=O)NCC1C2CN(C(=O)c3cnc(C)s3)CC12
CP003417607597
-20.51
O=C(c1cncs1)N1CC2CC2C1
CC(C)c1ncc(C(=O)N2CC3C(CNC(=O)CCF)C3C2)s1
CP003496156352
-20.44
O=C(c1cncs1)N1CC2CC2C1
CCCCC(C(=O)NCC1C2CN(C(=O)c3scnc3Cl)CC12)C(C)C
CP002676593763
-20.38
O=C(c1cncs1)N1CC2CC2C1
CCCC(CC(C)C)C(=O)NCC1C2CN(C(=O)c3cnc(C)s3)CC12
CP002676599225
-20.17
O=C(c1cncs1)N1CC2CC2C1
CC(NC(N)=O)C(=O)NCC1C2CN(C(=O)c3cncs3)CC12
CP003496144329
-20.14
O=C(c1cncs1)N1CC2CC2C1
Cc1nc(C)c(C(=O)N2CC3C(CNC(=O)CC(C)(C)C(F)F)C3C2)s1
CP002677527149
-20.12
O=C(c1cncs1)N1CC2CC2C1
CCC(CC)CC(=O)NCC1C2CN(C(=O)c3cncs3)CC12
CP003496036147
-20
O=C(c1cncs1)N1CC2CC2C1
CC(=O)NCCCCCC(=O)NCC1C2CN(C(=O)c3cncs3)CC12
CP002676540499
-19.98
O=C(c1cncs1)N1CC2CC2C1
CCCCOCC(=O)NCC1C2CN(C(=O)c3cnc(C#N)s3)CC12
CP003059293267
-19.94
O=C(c1cncs1)N1CC2CC2C1
CCOCC(=O)NCC1C2CN(C(=O)c3sc(C(C)(C)C)nc3C)CC12
CP002676289607
-19.9
O=C(c1cncs1)N1CC2CC2C1
CC=C(CC)C(=O)NCC1C2CN(C(=O)c3sc(COC)nc3C)CC12
CP002677395507
-19.88
O=C(c1cncs1)N1CC2CC2C1
CC(=O)c1ncc(C(=O)N2CC3C(CNC(=O)C(CO)C(C)C)C3C2)s1
CP002677129624
-19.75
O=C(c1cncs1)N1CC2CC2C1
COCc1ncsc1C(=O)N1CC2C(CNC(=O)C(F)C(C)(C)O)C2C1
CP002677441187
-19.11
O=C(c1cncs1)N1CC2CC2C1
CCc1ncc(C(=O)N2CC3C(CNC(=O)CCC(C)OC)C3C2)s1
CP003059329279
-18.78
O=C(c1cncs1)N1CC2CC2C1
CCC(CC)C(=O)NCC1C2CN(C(=O)c3scnc3Cl)CC12
CP003495992194
-18.51
O=C(c1cncs1)N1CC2CC2C1
Cc1ncsc1C(=O)N1CC2C(CNC(=O)CCC(C)C)C2C1
CP003495983909
-18.06
O=C(c1cncs1)N1CC2CC2C1
CC(C)SCC(=O)NCC1C2CN(C(=O)c3scnc3Cl)CC12
CP003495991623
-17.94
O=C(c1cncs1)N1CC2CC2C1
Cc1ncc(C(=O)N2CC3C(CNC(=O)C(C)CCO)C3C2)s1
CP003496170243
-17.05
O=C(c1cncs1)N1CC2CC2C1
Cc1ncsc1C(=O)N1CC2C(CNC(=O)CC(C)(C)C(F)F)C2C1
CP003059926934
-16.38
O=C(c1cncs1)N1CC2CC2C1
COCC(=O)NCC1C2CN(C(=O)c3cncs3)CC12
CP001494776254
-15.1
O=C(c1cncs1)N1CC2CC2C1
O=C(COCCO)NCC1C2CN(C(=O)c3scnc3Cl)CC12
CP003496131180
-14.07
O=C(c1cncs1)N1CC2CC2C1
CC1Cc2cc(C(=O)NCC3CCCN3C(=O)Cc3ccnc(F)c3)ccc2O1
CP000345451649
-30.97
O=C(NCC1CCCN1C(=O)Cc1ccncc1)c1ccc2c(c1)CCO2
Cn1c(=O)c(CNC(=O)c2ccc(Cl)c3cccnc23)cc2ccccc21
CP000530318305
-33
O=C(NCc1cc2ccccc2[nH]c1=O)c1cccc2cccnc12
CCOc1cc(C(=O)NCC[C@H]2CCCN2C(=O)c2ccc[nH]2)on1
CP003165926675
-27.33
O=C(NCC[C@H]1CCCN1C(=O)c1ccc[nH]1)c1ccno1
CCOc1cc(C(=O)NCC[C@H]2CCCN2C(=O)c2cccn2CC)on1
CP001941980197
-23.95
O=C(NCC[C@H]1CCCN1C(=O)c1ccc[nH]1)c1ccno1
CC(Cn1cc(-c2cccs2)nn1)NC(=O)c1cnn(C)c1-c1ccccc1
CP001116198540
-27.89
O=C(NCCn1cc(-c2cccs2)nn1)c1cn[nH]c1-c1ccccc1
O=C(Cn1cccc1)NC1CCN(C(=O)c2cscc2Cl)C1
CP003487070947
-26.89
O=C(Cn1cccc1)NC1CCN(C(=O)c2ccsc2)C1
CCc1cscc1C(=O)N1CC(NC(=O)C(C)n2cccc2)CC1C
CP003070373797
-24.13
O=C(Cn1cccc1)NC1CCN(C(=O)c2ccsc2)C1
Cc1cc(C(=O)N2CCC(NC(=O)Cn3c(C)ccc3C)C2)cs1
CP003457558700
-23.42
O=C(Cn1cccc1)NC1CCN(C(=O)c2ccsc2)C1
CC(CCNC(=O)c1ccc2ocnc2c1)NC(=O)C1=CCCCO1
CP003204946646
-23.23
O=C(NCCCNC(=O)c1ccc2ocnc2c1)C1=CCCCO1
CC1CCC(C(=O)NC2(CNC(=O)c3cncn3-c3ccccc3)CC2)C1
CP002201761554
-28.31
O=C(NCC1(NC(=O)C2CCCC2)CC1)c1cncn1-c1ccccc1
CC1CN(C(=O)C23CCC(CC2)C3)CC1CNC(=O)CCOc1cccnc1
CP000905978427
-24.48
O=C(CCOc1cccnc1)NCC1CCN(C(=O)C23CCC(CC2)C3)C1
CC1(C)OCc2c(C(=O)N3CCC(NC(=O)c4cc5cnccc5[nH]4)C3)n[nH]c21
CP000366323696
-30.59
O=C(NC1CCN(C(=O)c2n[nH]c3c2COC3)C1)c1cc2cnccc2[nH]1
CC1=NC(C(=O)NCC2(NC(=O)c3cc(-c4ccco4)on3)CCC2)CS1
CP002012304194
-26.08
O=C(NC1(CNC(=O)C2CSC=N2)CCC1)c1cc(-c2ccco2)on1
CCC(C(=O)NCC1CC(C)N(C(=O)c2cc(C)sn2)C1)C1CCOCC1
CP001829040381
-27.69
O=C(CC1CCOCC1)NCC1CCN(C(=O)c2ccsn2)C1
Cc1cc(C(=O)N2CC(CNC(=O)C(C)(C)C3CCOCC3)CC2C)ns1
CP001829040110
-26.64
O=C(CC1CCOCC1)NCC1CCN(C(=O)c2ccsn2)C1
CCOC(C(=O)NC(C)C1CCN(C(=O)c2ccsn2)C1)C1CCOCC1
CP001806736369
-25.56
O=C(CC1CCOCC1)NCC1CCN(C(=O)c2ccsn2)C1
CN(C[C@H]1CCCN1C(=O)C=Cc1ccncn1)C(=O)[C@H]1CC1(F)F
CP003038229265
-28.87
O=C(NC[C@H]1CCCN1C(=O)C=Cc1ccncn1)C1CC1
O=C(CC1(O)CCC1)N1CC2(C1)CN(C(=O)c1cnn3cccnc13)C2
CP002656053298
-22.63
O=C(CC1CCC1)N1CC2(C1)CN(C(=O)c1cnn3cccnc13)C2
O=C(NC1CC2CCC(C1)N2C(=O)CC1CC2CCC1C2)C1=CCSC1
CP002967525413
null
O=C(NC1CC2CCC(C1)N2C(=O)CC1CC2CCC1C2)C1=CCSC1
O=C(c1nccc2occc12)N1CCN(CCN2CCCS2(=O)=O)CC1
CP001733883969
-23.64
O=C(c1nccc2occc12)N1CCN(CCN2CCCS2(=O)=O)CC1
Cc1cc(CC(=O)N2CC3CC2CN(C(=O)CCc2cnn(C)c2C)C3)on1
CP000588704775
-25.86
O=C(CCc1cn[nH]c1)N1CC2CC(C1)N(C(=O)Cc1ccno1)C2
CCN(Cc1nnnn1C(C)C)CC1CCN(C(=O)C2CCN(C)CC2)CC1
CP000551053891
-39.84
O=C(C1CCNCC1)N1CCC(CNCc2nnn[nH]2)CC1
Cc1ccc(CC(=O)N2CCCC(N(C)C(=O)C=C(C3CC3)C3CC3)C2)s1
CP002062801334
-27.55
O=C(C=C(C1CC1)C1CC1)NC1CCCN(C(=O)Cc2cccs2)C1
Cc1cc(CC(=O)NC2CN(C(=O)CC(C(F)F)n3ccnc3)C2)n[nH]1
CP003003559942
-39.58
O=C(Cc1cc[nH]n1)NC1CN(C(=O)CCn2ccnc2)C1
CCn1ccc(CC(=O)N(C)C2CN(C(=O)CCn3ccnc3)C2)n1
CP003230949843
-34.51
O=C(Cc1cc[nH]n1)NC1CN(C(=O)CCn2ccnc2)C1
CC1(NC(=O)c2cn3cccnc3n2)CCN(Cc2ccc(Cl)s2)C1
CP002416794236
-48.87
O=C(NC1CCN(Cc2cccs2)C1)c1cn2cccnc2n1
COC(=O)c1ccc(C(=O)N[C@H]2CCN(C(=O)C=C3CCCCC3)C2)s1
CP002964244720
-29.39
O=C(N[C@H]1CCN(C(=O)C=C2CCCCC2)C1)c1cccs1
C[C@H]1CN(C(=O)C=C2CCCCC2)C[C@H]1NC(=O)c1cc(Cl)cs1
CP003322671578
-25.69
O=C(N[C@H]1CCN(C(=O)C=C2CCCCC2)C1)c1cccs1
CCc1nnc(C(=O)N2CCC(C3CCCCN3C(=O)CC3CCCC3)C2)[nH]1
CP000860133507
-27.49
O=C(c1nnc[nH]1)N1CCC(C2CCCCN2C(=O)CC2CCCC2)C1
CN(C)Cc1c[nH]c(C(=O)NCC2CCN(C(=O)C3CCCC3)CC2)c1
CP002732366552
-50.46
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
Cc1cc(C)c(C(=O)N(C)CC2CCN(C(=O)C3(F)CCCC3)CC2)[nH]1
CP002949406438
-28.23
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
COC(=O)c1ccc(C(=O)NCC2CCN(C(=O)C3CCCC3)CC2C)n1C
CP000641928107
-28.19
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1cc(Cl)c[nH]1
CP003359689107
-27.65
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
N#Cc1c[nH]c(C(=O)NCC2CCN(C(=O)C3CCCC3)CC2)c1
CP003150752371
-27.47
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCCc1ccc(C(=O)NC(C)C2(O)CCN(C(=O)C3CCC(C)C3)CC2)[nH]1
CP000747895814
-26.77
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
COC(=O)C1CCC(C(=O)N2CCC(CN(C)C(=O)c3cccn3C)CC2)C1
CP000920648482
-26.73
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
N#Cc1c[nH]c(C(=O)NCC2(F)CCN(C(=O)C3CCCC3O)CC2)c1
CP002599623203
-26.55
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCCn1cccc1C(=O)NCC1(C)CCN(C(=O)C2(OC)CCCC2)CC1
CP000704119511
-26.39
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCn1cc(Cl)cc1C(=O)NCC1(C)CCN(C(=O)C2CCCC2C)CC1
CP001799315017
-26.09
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
NC(=O)c1ccc(C(=O)NCC2CCN(C(=O)C3CCC(F)C3)CC2)[nH]1
CP002731744157
-24.16
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCn1cccc1C(=O)NCC1(O)CCN(C(=O)C2(OC)CCCC2)CC1
CP001882342779
-23.73
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
Cn1cccc1C(=O)NCC1(C)CCN(C(=O)C2CCCC2(C)C)CC1
CP002722634252
-23.63
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCc1ccc(C(=O)NCC2(O)CCN(C(=O)C3(O)CCCC3)CC2)[nH]1
CP002703811388
-23.35
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
COC1(C(=O)N2CCC(O)(CNC(=O)c3cc(C)c(C)[nH]3)CC2)CCCC1
CP001882343189
-23.22
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
COCc1ccc(C(=O)NCC2(C)CCN(C(=O)C3CCC(F)C3)CC2)[nH]1
CP001800360328
-22.89
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCC1CCCC1C(=O)N1CCC(CNC(=O)c2cc(C#N)c[nH]2)C(C)C1
CP001603203835
-21.97
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
Cc1cc[nH]c1C(=O)NCC1CCN(C(=O)C2CCCC2(C)C)CC1C
CP002359575379
-21.6
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCCC1CCCC1C(=O)N1CCC(CNC(=O)c2cc(C(N)=O)c[nH]2)CC1
CP001011121304
-20.59
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CC(=O)c1c[nH]c(C(=O)NCC2CCN(C(=O)C3CCCC3(C)C)CC2C)c1
CP000642542942
-20.32
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CN(CC1CCN(C(=O)C2(S(C)(=O)=O)CCCC2)CC1)C(=O)c1ccc[nH]1
CP002120999864
-19.97
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCN(CC1CCN(C(=O)C2(CC)CCCC2)CC1)C(=O)c1cc(C#N)c[nH]1
CP000811709571
null
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCC1(C(=O)N2CCC(CN(C)C(=O)c3cc(C(N)=O)c[nH]3)CC2)CCCC1
CP001136395462
null
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCC1CCCC1(C)C(=O)N1CCC(O)(CNC(=O)c2cccn2C)CC1
CP001882024248
null
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CC1CCC(C)(C(=O)N2CCC(O)(CNC(=O)c3cc(Cl)c[nH]3)CC2)C1
CP002703773471
null
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CC1CCC(C)(C(=O)N2CCC([C@H](C)NC(=O)c3cccn3C)CC2)C1
CP002752765655
null
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CCC1(C(=O)N2CCC(CN(C)C(=O)c3[nH]ccc3C)CC2)CCCC1
CP002949351840
null
O=C(NCC1CCN(C(=O)C2CCCC2)CC1)c1ccc[nH]1
CC(Cc1cccc(F)c1)NCc1cn(Cc2ccc(F)cn2)nn1
CP001575903413
-30.79
c1ccc(CCNCc2cn(Cc3ccccn3)nn2)cc1
CC(C)c1nnc(N2CCN(C(=O)[C@H]3CNC(=O)N3)CC2)o1
CP003468066448
-19.45
O=C1NC[C@H](C(=O)N2CCN(c3nnco3)CC2)N1
CCn1cc(Cl)c(CN2CCC3(CCOC3)C2)n1
CP000617999898
-49.35
c1cc(CN2CCC3(CCOC3)C2)n[nH]1
Cn1cc(Br)c(CN2CCC3(CCOC3)C2)n1
CP000032711292
-48.35
c1cc(CN2CCC3(CCOC3)C2)n[nH]1
Cc1nc(CC(=O)NC[C@H]2CCCN(C(=O)C3=CCOCC3)C2)c(C)s1
CP002772391532
-24.19
O=C(Cc1cscn1)NC[C@H]1CCCN(C(=O)C2=CCOCC2)C1
CC1(C#N)CN(C(=O)NCC2CC3CCC(C2)O3)CCO1
CP002550210796
null
O=C(NCC1CC2CCC(C1)O2)N1CCOCC1
CCOc1cccc(CC(=O)N2CC(N(C)C(=O)c3nccc4occc34)C2)n1
CP000183343874
-24.64
O=C(NC1CN(C(=O)Cc2ccccn2)C1)c1nccc2occc12